Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.004
I. W. G. A. L. Malhasi, C. Fernando, M. de Silva
Fine needle aspiration (FNA) has about 90% diagnostic accuracy for papillary thyroid carcinoma (PTC) in an adequate sample. Ignorance of relative significance of individual cytologic features may lead to misdiagnosis due to reliance on a single or few features. Our objective was to determine the usefulness of individual and most appropriate combined cytologic features, for diagnosis of PTC. H&E stained FNA smears of fifty cases each, of consecutive histologically confirmed PTC and benign thyroid cases (controls), reported over 3 years, were retrieved from the files. A total of 31 architectural, cytological and background features were assessed, blind to the final diagnosis and compared amongst the two groups. The statistical significance (p<0.05) of each parameter was determined by chi-square and odds ratio and combinations quality assessed by ROC curves.: Twenty features were found to be statistically significant. Fourteen highly significant (p<0.000) features included flat syncytial sheets, anatomical borders, true papillae, cellular swirls, individually dispersed cells with eosinophilic cytoplasm, anisonucleosis, elongated oval nuclei, powdery chromatin, nuclear outline irregularity, thickened nuclear membranes, crescent shaped nuclei, intranuclear inclusions, histocytoid cells and soap bubble cytoplasmic vacuolation. The six statistically significant features (p<0.05) included micro-acinar structures, cellular crowding, nuclear overlapping, nuclear grooves, squamoid cells and bubble gum colloid. The control group also showed some of these single cytologic features. All the combinations of ≥ 4 features had a statistical significance of p=0.000 and specificity and PPV of 100% with ROC showing excellent results. Using correct combination of cytologic features will increase accuracy of FNA diagnosis of PTC.
{"title":"Accuracy of different cytoarchitectural features in the diagnosis of papillary thyroid carcinoma by fine needle aspiration","authors":"I. W. G. A. L. Malhasi, C. Fernando, M. de Silva","doi":"10.18231/j.ijpo.2023.004","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.004","url":null,"abstract":"Fine needle aspiration (FNA) has about 90% diagnostic accuracy for papillary thyroid carcinoma (PTC) in an adequate sample. Ignorance of relative significance of individual cytologic features may lead to misdiagnosis due to reliance on a single or few features. Our objective was to determine the usefulness of individual and most appropriate combined cytologic features, for diagnosis of PTC. H&E stained FNA smears of fifty cases each, of consecutive histologically confirmed PTC and benign thyroid cases (controls), reported over 3 years, were retrieved from the files. A total of 31 architectural, cytological and background features were assessed, blind to the final diagnosis and compared amongst the two groups. The statistical significance (p<0.05) of each parameter was determined by chi-square and odds ratio and combinations quality assessed by ROC curves.: Twenty features were found to be statistically significant. Fourteen highly significant (p<0.000) features included flat syncytial sheets, anatomical borders, true papillae, cellular swirls, individually dispersed cells with eosinophilic cytoplasm, anisonucleosis, elongated oval nuclei, powdery chromatin, nuclear outline irregularity, thickened nuclear membranes, crescent shaped nuclei, intranuclear inclusions, histocytoid cells and soap bubble cytoplasmic vacuolation. The six statistically significant features (p<0.05) included micro-acinar structures, cellular crowding, nuclear overlapping, nuclear grooves, squamoid cells and bubble gum colloid. The control group also showed some of these single cytologic features. All the combinations of ≥ 4 features had a statistical significance of p=0.000 and specificity and PPV of 100% with ROC showing excellent results. Using correct combination of cytologic features will increase accuracy of FNA diagnosis of PTC.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123044298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.010
Siddhartha Sharma, N. Sood
Schwannoma is a benign peripheral nerve sheath tumor. It commonly occurs in head and neck region, upper extremities and dorsolumbar spine. The giant schwannoma as such is a rare occurring tumor. We present a series of three cases of giant schwannoma in unusual locations, masquerading as other soft tissue tumors.: Case 1: A 40-year-old male presented with a large exophytic ulcerated growth on his left thigh. The lesion was deep dermal in location. It was well circumscribed, partially encapsulated with extensive areas of hemorrhage and cystic change. Histopathology and immunohistochemistry (IHC) revealed the diagnosis of Benign Schwannoma with ancient changes. A 30-year-old woman presented with mid back ache and a mass in paravertebral location at T8 to T10 levels from last 2 years. The lesion was dermal in location. It was well circumscribed, partially encapsulated with extensive areas of hemorrhage and cystic change. Histopathology and IHC confirmed the diagnosis of Schwannoma with ancient changes. A 24-year-old male, presented with a 6x6 cm lesion over the scalp. It was well circumscribed, partially encapsulated with solid and cystic areas. Histologically, it turned out to be a Schwannoma. Giant schwannoma is a rare tumor which occasionally presents at unusual locations and poses a diagnostic challenge to both, the operating surgeon and the pathologist. These lesions clinically may mimic dermatofibroma, dermatofibrosarcoma and even trichilemmal tumors. These cases are being presented for their unusual presentation.
{"title":"Giant schwannoma masquerading as other soft tissue tumors: A series of three cases","authors":"Siddhartha Sharma, N. Sood","doi":"10.18231/j.ijpo.2023.010","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.010","url":null,"abstract":"Schwannoma is a benign peripheral nerve sheath tumor. It commonly occurs in head and neck region, upper extremities and dorsolumbar spine. The giant schwannoma as such is a rare occurring tumor. We present a series of three cases of giant schwannoma in unusual locations, masquerading as other soft tissue tumors.: Case 1: A 40-year-old male presented with a large exophytic ulcerated growth on his left thigh. The lesion was deep dermal in location. It was well circumscribed, partially encapsulated with extensive areas of hemorrhage and cystic change. Histopathology and immunohistochemistry (IHC) revealed the diagnosis of Benign Schwannoma with ancient changes. A 30-year-old woman presented with mid back ache and a mass in paravertebral location at T8 to T10 levels from last 2 years. The lesion was dermal in location. It was well circumscribed, partially encapsulated with extensive areas of hemorrhage and cystic change. Histopathology and IHC confirmed the diagnosis of Schwannoma with ancient changes. A 24-year-old male, presented with a 6x6 cm lesion over the scalp. It was well circumscribed, partially encapsulated with solid and cystic areas. Histologically, it turned out to be a Schwannoma. Giant schwannoma is a rare tumor which occasionally presents at unusual locations and poses a diagnostic challenge to both, the operating surgeon and the pathologist. These lesions clinically may mimic dermatofibroma, dermatofibrosarcoma and even trichilemmal tumors. These cases are being presented for their unusual presentation.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130279628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.021
Priyanka Patil, S. Agrawal, N. Dravid, Sumedh S Agrawal, Anand Tambat
Granulosa cell tumours (GCT) belong to the group of sex cord and stromal tumours of ovary. Adult granulosa cell tumours account for approximately 1% of all ovarian tumours and 95% of all granulosa cell tumours. They are found more often in postmenopausal than premenopausal women, with a peak incidence between 50 and 55 years of age. We present the case of a 35-year female who came with white discharge, irregular menses and excessive bleeding during menses since 5 to 6 months. The complete blood picture with peripheral smear examination, kidney and liver function tests were all within normal limits. CT abdomen was advised which revealed a large solid cystic lesion of left ovarian origin. Surgical intervention was done and histopathology revealed adult granulosa cell tumor of ovary.
{"title":"Adult granulosa cell tumor of ovary in a young female: A rare case report","authors":"Priyanka Patil, S. Agrawal, N. Dravid, Sumedh S Agrawal, Anand Tambat","doi":"10.18231/j.ijpo.2023.021","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.021","url":null,"abstract":"Granulosa cell tumours (GCT) belong to the group of sex cord and stromal tumours of ovary. Adult granulosa cell tumours account for approximately 1% of all ovarian tumours and 95% of all granulosa cell tumours. They are found more often in postmenopausal than premenopausal women, with a peak incidence between 50 and 55 years of age. We present the case of a 35-year female who came with white discharge, irregular menses and excessive bleeding during menses since 5 to 6 months. The complete blood picture with peripheral smear examination, kidney and liver function tests were all within normal limits. CT abdomen was advised which revealed a large solid cystic lesion of left ovarian origin. Surgical intervention was done and histopathology revealed adult granulosa cell tumor of ovary.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128951131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.006
Christine Kharshandi, V. Mane
The main objective of this study is to compare the Gel Card method and the Conventional Tube method for Coomb’s test. The standard procedures were being followed while performing the above mentioned two test. Based on an 8 months study, Gel card method was proven to be more reliable in concordance with its calculated p-value and the sensitivity. The advantages and disadvantages of which have been mentioned in the following. For Gel Card method, the principle of saphadex gel as a semi-solid medium is being used to trap any agglutination. For the Conventional Tube method, the SOP was being followed involving cell washing and confirmation via microscopy for any micro-clumps. The use of polyspecific antiglobulin was implemented for both the above test. The study showed p-value for Gel Card method to be < 0.05 which proves to be significant and the sensitivity of Gel Card method was also better compared to the Conventional Tube method. Our study showed that gel card is more sensitive, easy to perform and lesser time consumption, lesser sample volume plus standardized reporting. Results of Gel card can be preserved for 3-4 days. Avoidance of interobserver variability is also an added benefit due to the standard grading system. It is therefore an excellent method for detecting agglutination compared to the Conventional Tube method.
{"title":"A comparative study between gel card method and manual method for Coomb's test","authors":"Christine Kharshandi, V. Mane","doi":"10.18231/j.ijpo.2023.006","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.006","url":null,"abstract":"The main objective of this study is to compare the Gel Card method and the Conventional Tube method for Coomb’s test. The standard procedures were being followed while performing the above mentioned two test. Based on an 8 months study, Gel card method was proven to be more reliable in concordance with its calculated p-value and the sensitivity. The advantages and disadvantages of which have been mentioned in the following. For Gel Card method, the principle of saphadex gel as a semi-solid medium is being used to trap any agglutination. For the Conventional Tube method, the SOP was being followed involving cell washing and confirmation via microscopy for any micro-clumps. The use of polyspecific antiglobulin was implemented for both the above test. The study showed p-value for Gel Card method to be < 0.05 which proves to be significant and the sensitivity of Gel Card method was also better compared to the Conventional Tube method. Our study showed that gel card is more sensitive, easy to perform and lesser time consumption, lesser sample volume plus standardized reporting. Results of Gel card can be preserved for 3-4 days. Avoidance of interobserver variability is also an added benefit due to the standard grading system. It is therefore an excellent method for detecting agglutination compared to the Conventional Tube method.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130456317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.019
Valli Priyaa P, Senthilkumaran D, B. Srinivasamurthy, R. Bhat
: To present a rare case of endometrial cavity osseous material with an unusual finding of extramedullary hematopoiesis and a brief review of literature.: A 44-year-old female P1L1 with complaints of excessive bleeding per vaginum for 12 months. Pelvic examination showed approximately 16 weeks sized uterus. Radiologists found calcific material (?foreign body) in the anterior fundal wall of uterus. Total hysterectomy was done and sent to us for histopathological examination. On sectioning uterus, a bony spicule was seen freely lying within the cavity. Histopathology confirmed the bony nature of the foreign material which also showed hematopoietic component. Due to the associated finding of endometritis, there was high suspicion of retained fetal products in this case.: Recognition of osseous material within the endometrial cavity as a benign entity is important to avoid misdiagnosis as Carcinosarcoma microscopically, however complete clinicopathological correlation ensures correct diagnosis and to rule out retained products of conception, tuberculosis, and hematologic disease. Diagnosis and prompt treatment of foreign body within uterine cavity may be necessary to avoid complications like infertility and abnormal bleeding.
{"title":"Intriguing case of foreign body in uterine cavity","authors":"Valli Priyaa P, Senthilkumaran D, B. Srinivasamurthy, R. Bhat","doi":"10.18231/j.ijpo.2023.019","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.019","url":null,"abstract":": To present a rare case of endometrial cavity osseous material with an unusual finding of extramedullary hematopoiesis and a brief review of literature.: A 44-year-old female P1L1 with complaints of excessive bleeding per vaginum for 12 months. Pelvic examination showed approximately 16 weeks sized uterus. Radiologists found calcific material (?foreign body) in the anterior fundal wall of uterus. Total hysterectomy was done and sent to us for histopathological examination. On sectioning uterus, a bony spicule was seen freely lying within the cavity. Histopathology confirmed the bony nature of the foreign material which also showed hematopoietic component. Due to the associated finding of endometritis, there was high suspicion of retained fetal products in this case.: Recognition of osseous material within the endometrial cavity as a benign entity is important to avoid misdiagnosis as Carcinosarcoma microscopically, however complete clinicopathological correlation ensures correct diagnosis and to rule out retained products of conception, tuberculosis, and hematologic disease. Diagnosis and prompt treatment of foreign body within uterine cavity may be necessary to avoid complications like infertility and abnormal bleeding.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134177848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acrokeratosis verruciformis of Hopf (AKV) is a rare cutaneous autosomal dominant genodermatosis described by Hopf in 1931. It usually presents at birth or may appear as late as 5 decade of life. It is characterized by multiple hyperkeratotic, verrucous papules/plaques to multiple planar wart like lesions on dorsal aspects of hand and feet. Due to rarity of the case, we present a case of AKV in a 60-year-old male that was diagnosed on histopathology. We the authors have attempted to describe the histological features of AKV with differential diagnosis of these lesions through review of literature.
Hopf疣状角化Acrokeratosis of Hopf (AKV)是一种罕见的皮肤常染色体显性遗传病。它通常在出生时出现，也可能在50岁时出现。它的特征是手和脚背部的多个角化过度，疣状丘疹/斑块到多个平面疣样病变。由于罕见的情况下，我们提出一个病例AKV在60岁的男性被诊断为组织病理学。我们的作者已经试图描述AKV的组织学特征与鉴别诊断这些病变通过回顾文献。
{"title":"Acrokeratosis verruciformis of Hopf: A rare case report","authors":"Shushruta Mohanty, Sujata Panda, Deepika Sahu, Shilpa Padhi","doi":"10.18231/j.ijpo.2023.024","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.024","url":null,"abstract":"Acrokeratosis verruciformis of Hopf (AKV) is a rare cutaneous autosomal dominant genodermatosis described by Hopf in 1931. It usually presents at birth or may appear as late as 5 decade of life. It is characterized by multiple hyperkeratotic, verrucous papules/plaques to multiple planar wart like lesions on dorsal aspects of hand and feet. Due to rarity of the case, we present a case of AKV in a 60-year-old male that was diagnosed on histopathology. We the authors have attempted to describe the histological features of AKV with differential diagnosis of these lesions through review of literature.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131903660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.012
M. Barman, Naima Aziz, J. Devi
Retinoblastoma is one of the common intraocular malignancy in childhood. It’s incidence varies between 1 in 3300 to1 in 20,000 live birth. Retinal dysplasia is a rare disorder which can mimic retinoblastoma. Retinal dysplasia is a rare cause of childhood leucocoria, which can cause considerable diagnostic difficulty in the differentiation of benign and malignant intraocular pathologies Enucleation is often required for both these conditions. In this series we are discussing 4 cases of enucleated eyeball. Out of these 4 cases three cases were of retinoblastoma.4 case was done for post traumatic phthysis bulbi. In this case series we are discussing diagnostic and prognostic indicators of Retinoblastoma as well as retinal dysplasia.
{"title":"Histopathological findings of enucleated specimen of eye in children - A case series of 4 cases","authors":"M. Barman, Naima Aziz, J. Devi","doi":"10.18231/j.ijpo.2023.012","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.012","url":null,"abstract":"Retinoblastoma is one of the common intraocular malignancy in childhood. It’s incidence varies between 1 in 3300 to1 in 20,000 live birth. Retinal dysplasia is a rare disorder which can mimic retinoblastoma. Retinal dysplasia is a rare cause of childhood leucocoria, which can cause considerable diagnostic difficulty in the differentiation of benign and malignant intraocular pathologies Enucleation is often required for both these conditions. In this series we are discussing 4 cases of enucleated eyeball. Out of these 4 cases three cases were of retinoblastoma.4 case was done for post traumatic phthysis bulbi. In this case series we are discussing diagnostic and prognostic indicators of Retinoblastoma as well as retinal dysplasia.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116336516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.009
Faiyaz Ahmad, Faiza Samin, Ankita Mittal, S. Awasthi, Ariba Nasir
Lymphadenopathy can result due to an increase in lymphocytes in the lymph node due to various infections like tuberculosis and lymphoproliferative conditions. Granulomatous lymphadenitis causes an increase in inflammatory biomarkers which can be assessed by simple hemogram using TLC and DLC and ratios derived from it like NLR (Neutrophil Lymphocyte Ratio) and PLR (Platelet Lymphocyte Ratio). To establish the role of hematological and inflammatory biomarkers in granulomatous and non-granulomatous lymphadenitis.The study was performed in a tertiary care center from august 2020 to September 2022. The study included 150 patients with neck mass taking inclusion and exclusion criteria into account. Cytologically proven cases were categorised into granulomatous and non-granulomatous cases depending on cytological evaluation. Different laboratory parameters like TLC, DLC, ESR, CRP, NLR, and PLR were used to compare granulomatous lymphadenitis to non-granulomatous.In the studied population there were 92(61.3%) females and 58(38.7%) males but when compared to the non-granulomatous lymphadenitis group, females predominated by 70.7% hematological markers like NLR, PLR, and CRP in the granulomatous lymphadenitis group was significantly higher. The mean Neutrophil was considerably higher among granulomatous lymphadenitis but in non-granulomatous lymphadenitis, the group showed considerably greater mean lymphocytes.Tuberculosis is the most frequent clinical condition connected to cervical lymphadenopathy in our area. More often than not, women are involved. Hematological and biochemical parameters like NLR, PLR, and CRP can give us some indication before FNAC for the presence of granulomatous and non-granulomatous lymphadenitis. It will help the treating doctor think methodically about early case identification and avoid diagnostic delays in situations like tuberculosis, especially at the primary care level.
{"title":"Role of hematological and inflammatory marker in granulomatous compared to non-granulomatous lymphadenitis","authors":"Faiyaz Ahmad, Faiza Samin, Ankita Mittal, S. Awasthi, Ariba Nasir","doi":"10.18231/j.ijpo.2023.009","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.009","url":null,"abstract":"Lymphadenopathy can result due to an increase in lymphocytes in the lymph node due to various infections like tuberculosis and lymphoproliferative conditions. Granulomatous lymphadenitis causes an increase in inflammatory biomarkers which can be assessed by simple hemogram using TLC and DLC and ratios derived from it like NLR (Neutrophil Lymphocyte Ratio) and PLR (Platelet Lymphocyte Ratio). To establish the role of hematological and inflammatory biomarkers in granulomatous and non-granulomatous lymphadenitis.The study was performed in a tertiary care center from august 2020 to September 2022. The study included 150 patients with neck mass taking inclusion and exclusion criteria into account. Cytologically proven cases were categorised into granulomatous and non-granulomatous cases depending on cytological evaluation. Different laboratory parameters like TLC, DLC, ESR, CRP, NLR, and PLR were used to compare granulomatous lymphadenitis to non-granulomatous.In the studied population there were 92(61.3%) females and 58(38.7%) males but when compared to the non-granulomatous lymphadenitis group, females predominated by 70.7% hematological markers like NLR, PLR, and CRP in the granulomatous lymphadenitis group was significantly higher. The mean Neutrophil was considerably higher among granulomatous lymphadenitis but in non-granulomatous lymphadenitis, the group showed considerably greater mean lymphocytes.Tuberculosis is the most frequent clinical condition connected to cervical lymphadenopathy in our area. More often than not, women are involved. Hematological and biochemical parameters like NLR, PLR, and CRP can give us some indication before FNAC for the presence of granulomatous and non-granulomatous lymphadenitis. It will help the treating doctor think methodically about early case identification and avoid diagnostic delays in situations like tuberculosis, especially at the primary care level.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125767693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.022
A. Raza, Sumaiya Irfan, Noorin Zaidi, N. Lal
Vulvar fibroadenoma is a rare entity presenting at an unusual location. Here we present a case of a 45-year-old female, with painless, well-defined mass in the left labia majora for one year. On radiological examination, ultrasonography showed a well-defined rounded heterogeneously hypoechoic space occupying lesion. The mass was excised under local anesthesia. The histopathological examination revealed vulvar fibroadenoma.
{"title":"Vulvar swelling- A rare diagnosis","authors":"A. Raza, Sumaiya Irfan, Noorin Zaidi, N. Lal","doi":"10.18231/j.ijpo.2023.022","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.022","url":null,"abstract":"Vulvar fibroadenoma is a rare entity presenting at an unusual location. Here we present a case of a 45-year-old female, with painless, well-defined mass in the left labia majora for one year. On radiological examination, ultrasonography showed a well-defined rounded heterogeneously hypoechoic space occupying lesion. The mass was excised under local anesthesia. The histopathological examination revealed vulvar fibroadenoma.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"15 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124912809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.018
S. Palaniraj, G. Gopu, B. Jayanthi
Retroperitoneal liposarcomas are uncommon malignancy accounting for 0.15% of all malignancies. The overall survival and prognosis is predominantly based on the total completeness of resection i.e. margin status and the histopathologic grade of the tumour. The retroperitoneal sarcomas usually present late in the disease course and often develops local invasion of the vital structures at the time of clinical presentation which makes resection with clear margins difficult and challenging. Here we present a case of Giant dedifferentiated liposarcoma arising from retroperitoneum.
{"title":"Giant retroperitoneal dedifferentiated liposarcoma - A rare case report","authors":"S. Palaniraj, G. Gopu, B. Jayanthi","doi":"10.18231/j.ijpo.2023.018","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.018","url":null,"abstract":"Retroperitoneal liposarcomas are uncommon malignancy accounting for 0.15% of all malignancies. The overall survival and prognosis is predominantly based on the total completeness of resection i.e. margin status and the histopathologic grade of the tumour. The retroperitoneal sarcomas usually present late in the disease course and often develops local invasion of the vital structures at the time of clinical presentation which makes resection with clear margins difficult and challenging. Here we present a case of Giant dedifferentiated liposarcoma arising from retroperitoneum.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"374 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126174421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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