Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.023
Maria Reji, S. M. Thomas, Jessy M M
Infantile digital fibromatosis is a marked fibrous proliferation of infancy characterized by occurrence in the fingers and toes and a marked tendency for local recurrence. It accounts for 0.2% of registered soft tissue tumors. The lesion rarely exceeds 2 cm and tends to regress spontaneously. The presence of characteristic inclusion bodies in the cytoplasm of neoplastic fibroblasts distinguishes it from other fibromatosis. Current treatment recommendations include function-preserving excision and intralesional steroid injections for symptomatic lesions. Although lesions recur more than 60% of the time after excision, the ultimate prognosis is excellent.
{"title":"A rare case of inclusion body fibromatosis","authors":"Maria Reji, S. M. Thomas, Jessy M M","doi":"10.18231/j.ijpo.2023.023","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.023","url":null,"abstract":"Infantile digital fibromatosis is a marked fibrous proliferation of infancy characterized by occurrence in the fingers and toes and a marked tendency for local recurrence. It accounts for 0.2% of registered soft tissue tumors. The lesion rarely exceeds 2 cm and tends to regress spontaneously. The presence of characteristic inclusion bodies in the cytoplasm of neoplastic fibroblasts distinguishes it from other fibromatosis. Current treatment recommendations include function-preserving excision and intralesional steroid injections for symptomatic lesions. Although lesions recur more than 60% of the time after excision, the ultimate prognosis is excellent.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127119125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.015
Neeharika Phukan, J. Devi
: Aggressive angiomyxoma is a rare but locally aggressive infiltrative mesenchymal tumour arising in the soft tissues of the lower genital tract. Incidence is very less (only about 350 cases have been recorded in the literature) with female to male ratio of 6:1. Average age at presentation is around 40 years.: A 32 years old female presented with multiple swelling in the vulval region for 1 and a half years associated with mild pain. The patient complains of dysmenorrhoea, pressure sensation, pelvic fullness, dyspepsia, weight loss and generalised weakness. She is married and has a 3-year old male child. Her menstrual cycle is regular with normal menses. FNAC of the vulval swelling was suggestive of angiomyxoma. The swelling was excised in the Gynaecological Operation Theatre and the specimen was sent to the Department of Pathology for Histopathological examination where it was diagnosed as aggressive angiomyxoma. On follow up, the patient was healthy with no complains of recurrence so far. : Aggressive angiomyxoma is an aggressive tumour because it has a high risk of infiltration and local recurrence. Therefore, it should be distinguished from other myxoid tumours. Preoperative cytological diagnosis helps in surgical management with appropriate wide local excision with clear margins.
{"title":"Cytodiagnosis of multilobulated aggressive angiomyxoma clinically mimicking sarcoma – A case report","authors":"Neeharika Phukan, J. Devi","doi":"10.18231/j.ijpo.2023.015","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.015","url":null,"abstract":": Aggressive angiomyxoma is a rare but locally aggressive infiltrative mesenchymal tumour arising in the soft tissues of the lower genital tract. Incidence is very less (only about 350 cases have been recorded in the literature) with female to male ratio of 6:1. Average age at presentation is around 40 years.: A 32 years old female presented with multiple swelling in the vulval region for 1 and a half years associated with mild pain. The patient complains of dysmenorrhoea, pressure sensation, pelvic fullness, dyspepsia, weight loss and generalised weakness. She is married and has a 3-year old male child. Her menstrual cycle is regular with normal menses. FNAC of the vulval swelling was suggestive of angiomyxoma. The swelling was excised in the Gynaecological Operation Theatre and the specimen was sent to the Department of Pathology for Histopathological examination where it was diagnosed as aggressive angiomyxoma. On follow up, the patient was healthy with no complains of recurrence so far. : Aggressive angiomyxoma is an aggressive tumour because it has a high risk of infiltration and local recurrence. Therefore, it should be distinguished from other myxoid tumours. Preoperative cytological diagnosis helps in surgical management with appropriate wide local excision with clear margins.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116830289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.001
Banushree C S
Midline destructive lesions (MDLs) are a diagnostic challenge due to an extensive differential diagnosis and vague presenting signs and symptoms. It may be due to neoplastic, autoimmune, traumatic, infectious, or unknown. The lethal lesions are characterized by ulcerative destruction of midline structures of the face like the nose, paranasal sinus and palate. A spectrum of diseases with myriad clinicopathological features can present as midline destructive lesions. Immunohistochemistry has played a major role in discerning the wide range of diseases into specific categories over the years.
{"title":"Midline destructive lesions: A diagnostic challenge","authors":"Banushree C S","doi":"10.18231/j.ijpo.2023.001","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.001","url":null,"abstract":"Midline destructive lesions (MDLs) are a diagnostic challenge due to an extensive differential diagnosis and vague presenting signs and symptoms. It may be due to neoplastic, autoimmune, traumatic, infectious, or unknown. The lethal lesions are characterized by ulcerative destruction of midline structures of the face like the nose, paranasal sinus and palate. A spectrum of diseases with myriad clinicopathological features can present as midline destructive lesions. Immunohistochemistry has played a major role in discerning the wide range of diseases into specific categories over the years.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122210017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.002
Jahnavi Marachapu, Swati Vij
: Chronic lymphocytic thyroiditis is autoimmune thyroiditis; it is considered as second most common thyroid disorder diagnosed on FNAC following colloid goitre. FNAC is a reliable and efficient method for diagnosing these thyroid lesions. Chronic Lymphocytic thyroiditis frequently affects women, primarily compared to men and is commonly found with hypothyroidism, euthyroidism or every so often with hyperthyroidism. The incidence rate of Hashimoto’s thyroiditis is 1–4%, with an occurrence of 30–60/100000 population per year. Autoimmune thyroiditis can be categorised on the cytomorphological features of FNAC. To compare FNAC cytological findings with TFT in Chronic lymphocytic thyroiditis. One hundred ten patients with thyroid swellings were presented for FNAC examination, serology of TFT and Anti TPO antibodies and Ultrasonography during 2020–2021. In addition, fine needle aspiration cytology was performed using non-aspiration or aspiration techniques. TFT and Anti- TPO antibodies were performed on Avion CLX 120 auto analyser based on the Chemiluminescence method. Out of 110 cases of midline neck swelling presented in our department, Autoimmune Thyroiditis was observed in 43 cases. The most affected age group of lymphocytic thyroiditis was 21–30 years, with the male: female ratio being 1:3. Most of the patients presented with diffuse swelling and few presented with nodular swelling. The Grading of the lymphocytic thyroiditis was done by the criteria used by Bhatia et al Anti-TPO antibody was elevated in 19 cases (26.2%), and TSH was elevated in 28 cases (40.81%). These cases were diagnosed as autoimmune thyroiditis on cytology, clinically and also correlating with radiological findings. Grade 3 lymphoid infiltrate was seen in 53.33% (16/30) cases, and Grade 2, lymphoid infiltrate was seen in eight cases (62.50%). Grade 1 lymphoid infiltrate was seen in five cases (11.63%). Among 43 cases, 28 cases (65.12%) show hypothyroidism, 7 cases (16.28%) show hyper, and 8 cases (18.60%) show Euthyroidism. Among these 43 cases, 26 cases showed diffuse thyroid swelling on ultrasonography, and 7 cases showed solitary nodule. Grade 3 lymphocytic infiltration statistically correlates with anti-TPO and TSH in conjunction with ultrasonography findings of diffuse enlargement of the thyroid gland. The presence of Hurthle cell change, giant cells, anisonucleosus, and granulomas do not find to be any statistical correlation with lymphocytic thyroiditis as these cases are primarily corresponding to Grade 1 and Grade 2. Through this study, we conclude that FNAC remains the gold standard method despite having different diagnostic modalities accessible for diagnosing thyroid lesions. Grading of FNAC Smears depends on lymphocytic infiltration of the thyroid follicles, along with positivity for antithyroid antibodies (anti-TPO antibody) and TSH. These findings are firmly associated with Chronic Lymphocytic Thyroiditis.
{"title":"A study of fine needle aspiration cytology findings with thyroid function test, anti-thyroid antibody, and clinical pathological parameters in cases of chronic lymphocytic thyroiditis","authors":"Jahnavi Marachapu, Swati Vij","doi":"10.18231/j.ijpo.2023.002","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.002","url":null,"abstract":": Chronic lymphocytic thyroiditis is autoimmune thyroiditis; it is considered as second most common thyroid disorder diagnosed on FNAC following colloid goitre. FNAC is a reliable and efficient method for diagnosing these thyroid lesions. Chronic Lymphocytic thyroiditis frequently affects women, primarily compared to men and is commonly found with hypothyroidism, euthyroidism or every so often with hyperthyroidism. The incidence rate of Hashimoto’s thyroiditis is 1–4%, with an occurrence of 30–60/100000 population per year. Autoimmune thyroiditis can be categorised on the cytomorphological features of FNAC. To compare FNAC cytological findings with TFT in Chronic lymphocytic thyroiditis. One hundred ten patients with thyroid swellings were presented for FNAC examination, serology of TFT and Anti TPO antibodies and Ultrasonography during 2020–2021. In addition, fine needle aspiration cytology was performed using non-aspiration or aspiration techniques. TFT and Anti- TPO antibodies were performed on Avion CLX 120 auto analyser based on the Chemiluminescence method. Out of 110 cases of midline neck swelling presented in our department, Autoimmune Thyroiditis was observed in 43 cases. The most affected age group of lymphocytic thyroiditis was 21–30 years, with the male: female ratio being 1:3. Most of the patients presented with diffuse swelling and few presented with nodular swelling. The Grading of the lymphocytic thyroiditis was done by the criteria used by Bhatia et al Anti-TPO antibody was elevated in 19 cases (26.2%), and TSH was elevated in 28 cases (40.81%). These cases were diagnosed as autoimmune thyroiditis on cytology, clinically and also correlating with radiological findings. Grade 3 lymphoid infiltrate was seen in 53.33% (16/30) cases, and Grade 2, lymphoid infiltrate was seen in eight cases (62.50%). Grade 1 lymphoid infiltrate was seen in five cases (11.63%). Among 43 cases, 28 cases (65.12%) show hypothyroidism, 7 cases (16.28%) show hyper, and 8 cases (18.60%) show Euthyroidism. Among these 43 cases, 26 cases showed diffuse thyroid swelling on ultrasonography, and 7 cases showed solitary nodule. Grade 3 lymphocytic infiltration statistically correlates with anti-TPO and TSH in conjunction with ultrasonography findings of diffuse enlargement of the thyroid gland. The presence of Hurthle cell change, giant cells, anisonucleosus, and granulomas do not find to be any statistical correlation with lymphocytic thyroiditis as these cases are primarily corresponding to Grade 1 and Grade 2. Through this study, we conclude that FNAC remains the gold standard method despite having different diagnostic modalities accessible for diagnosing thyroid lesions. Grading of FNAC Smears depends on lymphocytic infiltration of the thyroid follicles, along with positivity for antithyroid antibodies (anti-TPO antibody) and TSH. These findings are firmly associated with Chronic Lymphocytic Thyroiditis.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"542 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127051616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.017
V. Kaira, Pankaj Kaira, Rohit R Sharma
Primary leiomyosarcoma (LMS) of the tongue is an extremely rare, highly aggressive malignancy associated with poor survival outcome. We report a case of 60 years old male who presented with growth left lateral border of tongue since 6 months. Histopathological examination of the excised growth confirmed the diagnosis of LMS. An exhaustive panel of immunohistochemical markers helped in ruling out other malignant spindle cell differentials.
{"title":"Primary leiomyosarcoma of tongue: A relatively uncommon entity occurring at an exceedingly rare site","authors":"V. Kaira, Pankaj Kaira, Rohit R Sharma","doi":"10.18231/j.ijpo.2023.017","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.017","url":null,"abstract":"Primary leiomyosarcoma (LMS) of the tongue is an extremely rare, highly aggressive malignancy associated with poor survival outcome. We report a case of 60 years old male who presented with growth left lateral border of tongue since 6 months. Histopathological examination of the excised growth confirmed the diagnosis of LMS. An exhaustive panel of immunohistochemical markers helped in ruling out other malignant spindle cell differentials.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121529083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.008
Satarupa T Samanta, S. Kapoor, K. Kaur, Paheli Maru, P. Trivedi
Cytological evaluation of fluids for sarcomatous exfoliation is extremely rare. However, recently studies have come up describing characteristics of sarcomatous malignancies exfoliating into fluids but study from an Indian experience is still lacking. Description of clinico-pathological landscape in known cases of sarcomas, involving body fluid with emphasis on cytomorphologic details. Study includes cases reported as positive for involvement by sarcoma on fluid cytology including pleural, ascitic and cerebrospinal fluid (CSF) specimens between Jan 2016 to June 2022. Cases were retrieved and reviewed for cytomorphologic features which were subsequently correlated with its parent histology and IHC. IHC was applied on cell blocks for two cases where involvement was doubtful. In total, 21 fluid samples/cases including 4 CSF, 6 ascitic and 11 pleural fluid specimens were incorporated. Case spectrum comprised of 6 cases of Ewing Sarcoma (ES), 3 cases of rhabdomyosarcoma (RMS), 3 cases of osteosarcoma (OS), 2 cases of malignant peripheral nerve sheath tumor (MPNST), 2 cases of synovial sarcoma (SS), a case each of chondrosarcoma (CS), leiomyosarcoma (LMS) angiosarcoma (AS) and two cases of other malignancies with exfoliation of their sarcomatous component. Two cases presented as isolated latent metastasis so an IHC panel was applied to exclude involvement by secondary malignancy and prove involvement by primary diagnosed sarcoma.Majority of exfoliated sarcomas presented with epithelioidto pleomorphic morphology where at times it becomes obligatory to rule out occurrence of a secondary malignancy. It’s the first study from an Indian institute’s perspective that reflects upon such diversity of sarcomas with variability in morphology on exfoliation which can be overwhelming for a cytopathologist at times. IHC panel might be used when clinical background is unknown or when involvement is uncertain. More studies are needed that can help come up with recommendations that address such problems.
{"title":"Sarcomas in fluid cytology: Experience from a tertiary care centre in India","authors":"Satarupa T Samanta, S. Kapoor, K. Kaur, Paheli Maru, P. Trivedi","doi":"10.18231/j.ijpo.2023.008","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.008","url":null,"abstract":"Cytological evaluation of fluids for sarcomatous exfoliation is extremely rare. However, recently studies have come up describing characteristics of sarcomatous malignancies exfoliating into fluids but study from an Indian experience is still lacking. Description of clinico-pathological landscape in known cases of sarcomas, involving body fluid with emphasis on cytomorphologic details. Study includes cases reported as positive for involvement by sarcoma on fluid cytology including pleural, ascitic and cerebrospinal fluid (CSF) specimens between Jan 2016 to June 2022. Cases were retrieved and reviewed for cytomorphologic features which were subsequently correlated with its parent histology and IHC. IHC was applied on cell blocks for two cases where involvement was doubtful. In total, 21 fluid samples/cases including 4 CSF, 6 ascitic and 11 pleural fluid specimens were incorporated. Case spectrum comprised of 6 cases of Ewing Sarcoma (ES), 3 cases of rhabdomyosarcoma (RMS), 3 cases of osteosarcoma (OS), 2 cases of malignant peripheral nerve sheath tumor (MPNST), 2 cases of synovial sarcoma (SS), a case each of chondrosarcoma (CS), leiomyosarcoma (LMS) angiosarcoma (AS) and two cases of other malignancies with exfoliation of their sarcomatous component. Two cases presented as isolated latent metastasis so an IHC panel was applied to exclude involvement by secondary malignancy and prove involvement by primary diagnosed sarcoma.Majority of exfoliated sarcomas presented with epithelioidto pleomorphic morphology where at times it becomes obligatory to rule out occurrence of a secondary malignancy. It’s the first study from an Indian institute’s perspective that reflects upon such diversity of sarcomas with variability in morphology on exfoliation which can be overwhelming for a cytopathologist at times. IHC panel might be used when clinical background is unknown or when involvement is uncertain. More studies are needed that can help come up with recommendations that address such problems.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132674684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.020
K. Varma, S. Tripathi, N. Sharma, V. Misra
Mammary hamartoma (MH) is an infrequent form of breast tumor that accounts for approximately 4.8% of all benign breast lesions. Myoid (muscular) hamartomas are uncommon benign breast lesions that are considered to be a variant of mammary hamartomas. Since the pathogenesis of MH is poorly understood, its true incidence is under-reported by clinicians and as well as pathologists.Thus, we report this case of MH in a middle-aged female, who presented with a large breast mass mimicking phyllodes tumor and giant fibroadenoma, however, histopathology and immunohistochemical examination aided its diagnosis as Myoid Hamartoma. We present this case to highlight this rare benign breast lesion.
{"title":"Myoid hamartoma of breast clinically masquadering as phyllodes tumor- A rare case report","authors":"K. Varma, S. Tripathi, N. Sharma, V. Misra","doi":"10.18231/j.ijpo.2023.020","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.020","url":null,"abstract":"Mammary hamartoma (MH) is an infrequent form of breast tumor that accounts for approximately 4.8% of all benign breast lesions. Myoid (muscular) hamartomas are uncommon benign breast lesions that are considered to be a variant of mammary hamartomas. Since the pathogenesis of MH is poorly understood, its true incidence is under-reported by clinicians and as well as pathologists.Thus, we report this case of MH in a middle-aged female, who presented with a large breast mass mimicking phyllodes tumor and giant fibroadenoma, however, histopathology and immunohistochemical examination aided its diagnosis as Myoid Hamartoma. We present this case to highlight this rare benign breast lesion.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130926505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.18231/j.ijpo.2023.013
Saket Sharma, Jhanvi Makwana, Riya Kaka, Moushumi Mandal
Bone marrow examination is an essential tool for diagnosis of many diseases including both hematological and non hematological tumors. Bone marrow is commonly involved by many metastatic solid tumors. Bone marrow aspirates, and biopsies have been found to be more useful than radiological investigations in early diagnosis of bone marrow metastasis.Here we present a case of a 75 years old male patient presenting with acute sudden onset chest pain along with multiple lytic sclerotic foci in lumbar vertebrae, bilateral ribs, clavicle, scapula and sternum along with fractures in multiple ribs. CBC findings showed anemia with thrombocytopenia. Bone marrow examination revealed an infiltration of a metastatic tumor in bone marrow which was further confirmed to be of lower gastrointestinal tract in origin on IHC findings.A high suspicion for bone marrow metastasis should be considered in cases who present primarily with abnormalities in peripheral blood count and a vigilant search for metastatic cells on aspirate smears and imprint smears can help in early diagnosis of bone marrow metastasis by solid tumors.
{"title":"An unexpected finding of bone marrow metastasis from adenocarcinoma of lower gastrointestinal tract origin: Case report","authors":"Saket Sharma, Jhanvi Makwana, Riya Kaka, Moushumi Mandal","doi":"10.18231/j.ijpo.2023.013","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.013","url":null,"abstract":"Bone marrow examination is an essential tool for diagnosis of many diseases including both hematological and non hematological tumors. Bone marrow is commonly involved by many metastatic solid tumors. Bone marrow aspirates, and biopsies have been found to be more useful than radiological investigations in early diagnosis of bone marrow metastasis.Here we present a case of a 75 years old male patient presenting with acute sudden onset chest pain along with multiple lytic sclerotic foci in lumbar vertebrae, bilateral ribs, clavicle, scapula and sternum along with fractures in multiple ribs. CBC findings showed anemia with thrombocytopenia. Bone marrow examination revealed an infiltration of a metastatic tumor in bone marrow which was further confirmed to be of lower gastrointestinal tract in origin on IHC findings.A high suspicion for bone marrow metastasis should be considered in cases who present primarily with abnormalities in peripheral blood count and a vigilant search for metastatic cells on aspirate smears and imprint smears can help in early diagnosis of bone marrow metastasis by solid tumors.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116905245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.074
S. Asotra, Shikha Sharma, U. K. Chandel
Testicular tumors are relatively rare and comprise 1% of all male cancers worldwide with peak prevalence in the age group 15-35 years. Testicular lesions have a varied histomorphological spectrum and are largely categorized as non-neoplastic and neoplastic lesions.To study the incidence of testicular lesions, to study the histomorphological spectrum of testicular lesions including non-neoplastic as well as neoplastic lesions and to determine age-wise distribution, laterality and clinical presentation in testicular lesions.The present study is an observational study, carried out in the Pathology Department of Indira Gandhi Medical college, a tertiary care hospital in the northern India, over a duration of two years i.e from June 2020 to May 2022. A total of 52 radical orchidectomy and testicular biopsies were studied for gross and microscopic findings. 45 orchidectomy specimens and 7 testicular biopsies were studied. Out of these, 42 cases were non neoplastic and 10 were neoplastic. Maximum number of patients presented in the 2 & 4 decade of life. Undescended testis was the most common non-neoplastic lesion (17/42;40.47%), followed by testicular torsion (12/42;28.57%). Seminoma was the most common neoplastic lesions (50%), followed by Mixed Germ Cell Tumors (20%) and Non-Hodgkin lymphoma (20%) and a single case of yolk sac tumor (10%). Clinically, most of the patients presented with scrotal swelling (58.53%). Right testis was involved more commonly (32/52;61.53%). Testicular cancers represent 10.5% of all male reproductive cancers in India. Germ cell tumors accounted for highest percentage of cases with a commonest subtype of seminoma followed by mixed germ cell tumors. Histopathologic examination can help in accurately diagnosing and determining the prognosis of these rare tumor and tumor like lesions of testis.
{"title":"Histopathological spectrum of testicular lesions in a tertiary care hospital","authors":"S. Asotra, Shikha Sharma, U. K. Chandel","doi":"10.18231/j.ijpo.2022.074","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.074","url":null,"abstract":"Testicular tumors are relatively rare and comprise 1% of all male cancers worldwide with peak prevalence in the age group 15-35 years. Testicular lesions have a varied histomorphological spectrum and are largely categorized as non-neoplastic and neoplastic lesions.To study the incidence of testicular lesions, to study the histomorphological spectrum of testicular lesions including non-neoplastic as well as neoplastic lesions and to determine age-wise distribution, laterality and clinical presentation in testicular lesions.The present study is an observational study, carried out in the Pathology Department of Indira Gandhi Medical college, a tertiary care hospital in the northern India, over a duration of two years i.e from June 2020 to May 2022. A total of 52 radical orchidectomy and testicular biopsies were studied for gross and microscopic findings. 45 orchidectomy specimens and 7 testicular biopsies were studied. Out of these, 42 cases were non neoplastic and 10 were neoplastic. Maximum number of patients presented in the 2 & 4 decade of life. Undescended testis was the most common non-neoplastic lesion (17/42;40.47%), followed by testicular torsion (12/42;28.57%). Seminoma was the most common neoplastic lesions (50%), followed by Mixed Germ Cell Tumors (20%) and Non-Hodgkin lymphoma (20%) and a single case of yolk sac tumor (10%). Clinically, most of the patients presented with scrotal swelling (58.53%). Right testis was involved more commonly (32/52;61.53%). Testicular cancers represent 10.5% of all male reproductive cancers in India. Germ cell tumors accounted for highest percentage of cases with a commonest subtype of seminoma followed by mixed germ cell tumors. Histopathologic examination can help in accurately diagnosing and determining the prognosis of these rare tumor and tumor like lesions of testis.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125208880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.18231/j.ijpo.2022.082
Mrudula Sudula, M. Tejaswi, Naushaba Tazeen, Tasneem Fathima
Giant juvenile fibroadenoma is a rare variant of more common benign lesion, fibro adenoma observed in younger population. They present with rapidly enlarging single or multiple breast masses in one or both the breast. A 10-year-old pre-pubertal girl presented with large lump in left breast followed by right breast lump. FNAC was suggestive of fibroadenoma, and histopathology confirmed the diagnosis. To understand the genetic basis of common entity like fibroadenoma with a rare presentation in very young age, the tissue block was subjected to gene sequencing and identified MED 12 gene mutation. It leads us to the possibility of new treatment modalities of targeting the causative gene and thus sparing the patient from invasive procedures.
{"title":"MED 12 gene mutation in a case of bilateral giant juvenile fibroadenoma","authors":"Mrudula Sudula, M. Tejaswi, Naushaba Tazeen, Tasneem Fathima","doi":"10.18231/j.ijpo.2022.082","DOIUrl":"https://doi.org/10.18231/j.ijpo.2022.082","url":null,"abstract":"Giant juvenile fibroadenoma is a rare variant of more common benign lesion, fibro adenoma observed in younger population. They present with rapidly enlarging single or multiple breast masses in one or both the breast. A 10-year-old pre-pubertal girl presented with large lump in left breast followed by right breast lump. FNAC was suggestive of fibroadenoma, and histopathology confirmed the diagnosis. To understand the genetic basis of common entity like fibroadenoma with a rare presentation in very young age, the tissue block was subjected to gene sequencing and identified MED 12 gene mutation. It leads us to the possibility of new treatment modalities of targeting the causative gene and thus sparing the patient from invasive procedures.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124768924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：