Background: Meningiomas are the most prevalent primary intracranial tumors, which are treated with surgical resection. This procedure may result in cranial defects, leading to significant functional and aesthetic impairments. Lately, acrylic cranioplasty has emerged as a promising technique for repairing these defects. Objectives: The current retrospective review investigated patients, who underwent reconstructive cranioplasty following meningioma surgery between November 2021 and March 2023. Methods: Thirteen patients, who underwent cranioplasty surgery to repair extensive skull defects following meningioma surgery, were included as subjects. Eleven patients were female and all of them had a history of using progesterone contraception for 10 to 30 years. Two patients were male and had comorbid diabetes mellitus. Patients’ ages varied between 39 and 59 years old. The interval between craniectomy and cranioplasty was about 45 days. The material used for cranioplasty was polymethyl methacrylate prostheses. It started with a CT scan to determine the location and size of the skull defect. We reconstructed the defect, using computer-aided design and computer-aided manufacturing (CAD/CAM) to produce a prosthesis that was specific to each patient. This 3D-printed prosthesis was designed to manufacture a mold, which was sterilized and intraoperatively used. Results: We conducted post-operative surgery follow-up for up to 3 months. After 1 month of post-operative surgery follow-up, 2 out of our 13 patients developed cerebrospinal fluid leakage. Conclusions: Acrylic cranioplasty using CAD/CAM technology and 3D printing has shown potential for producing patient-specific implants to repair extensive skull defects. However, careful monitoring for post-operative complications is essential.
{"title":"Acrylic Cranioplasty for Cranial Defects Following Meningioma Surgery: A Case Series","authors":"Khamim Thohari, S. Siahaan, Natalia Yuwono, Areta Idarto, Rafi Daffa Dzaky","doi":"10.5812/ijcm-144927","DOIUrl":"https://doi.org/10.5812/ijcm-144927","url":null,"abstract":"Background: Meningiomas are the most prevalent primary intracranial tumors, which are treated with surgical resection. This procedure may result in cranial defects, leading to significant functional and aesthetic impairments. Lately, acrylic cranioplasty has emerged as a promising technique for repairing these defects. Objectives: The current retrospective review investigated patients, who underwent reconstructive cranioplasty following meningioma surgery between November 2021 and March 2023. Methods: Thirteen patients, who underwent cranioplasty surgery to repair extensive skull defects following meningioma surgery, were included as subjects. Eleven patients were female and all of them had a history of using progesterone contraception for 10 to 30 years. Two patients were male and had comorbid diabetes mellitus. Patients’ ages varied between 39 and 59 years old. The interval between craniectomy and cranioplasty was about 45 days. The material used for cranioplasty was polymethyl methacrylate prostheses. It started with a CT scan to determine the location and size of the skull defect. We reconstructed the defect, using computer-aided design and computer-aided manufacturing (CAD/CAM) to produce a prosthesis that was specific to each patient. This 3D-printed prosthesis was designed to manufacture a mold, which was sterilized and intraoperatively used. Results: We conducted post-operative surgery follow-up for up to 3 months. After 1 month of post-operative surgery follow-up, 2 out of our 13 patients developed cerebrospinal fluid leakage. Conclusions: Acrylic cranioplasty using CAD/CAM technology and 3D printing has shown potential for producing patient-specific implants to repair extensive skull defects. However, careful monitoring for post-operative complications is essential.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elmira Rostamnejad, Ronak Rashidi, Zohreh Akbari, M. Maghsoudloo, Mehrdad Hashemi, Amirnader Emami Razavi, M. Entezari, Majid Sadeghizadeh
Background: Breast cancer (BC) is the leading cause of cancer-associated mortality in women worldwide. However, the molecular mechanism underlying the process is still unclear. In this regard, bioinformatics studies play a decisive role in facilitating the path of biological investigations and can ultimately lead to the identification of better molecular candidates for further study. Objectives: Due to the abnormal expression of many coding and non-coding genes in all types of cancers and their relationship with various mechanisms of carcinogenesis, this study aimed at evaluating the expression levels of certain coding and non-coding genes involved in BC based on bioinformatics findings and laboratory investigations. Methods: Gene expression dataset, module extraction, functional enrichment analysis, protein-protein interaction network construction, and RT-qPCR were performed based on bioinformatics methods and laboratory investigations. Additionally, the promoter region mutations of these genes were investigated, using sequencing of extracted DNAs from formalin-fixed paraffin-embedded (FFPE) tumor tissues. Results: A module was selected as a candidate for further investigation. Estrogen receptor 1 (ESR1) and forkhead box A1 (FOXA1) showed the highest degrees in the PPI network with 9 and 7 links, respectively. Furthermore, the expression levels of the FOXA1 gene, RNA component of mitochondrial RNA processing endoribonuclease (RMRP), and nuclear enriched abundant transcript 1 (NEAT1) were significantly upregulated in the tumor group compared to the control group (in order, P = 0.044, P = 0.014, and P = 0.0004). The tumors of patients with positive metastasis displayed significantly higher levels of NEAT1 and RMRP expression compared to those of negative metastasis samples (P < 0.05). Moreover, the expression level of RMRP dramatically decreased in HER2-positive patients compared to negative samples (P = 0.011). Finally, no mutations were observed in the promoter sequencing of positive metastasis samples compared to normal samples. Conclusions: The upregulation levels of all three examined genes may correlate with BC progression. Therefore, they could potentially be used as biomarkers for detecting BC development.
背景：乳腺癌（BC）是全球妇女因癌症死亡的主要原因。然而，该过程的分子机制仍不清楚。在这方面，生物信息学研究在促进生物学研究的道路上起着决定性的作用，并能最终确定更好的候选分子供进一步研究。研究目的鉴于各类癌症中许多编码基因和非编码基因的异常表达及其与各种致癌机制的关系，本研究旨在根据生物信息学研究结果和实验室调查，评估参与 BC 癌症的某些编码基因和非编码基因的表达水平。研究方法基于生物信息学方法和实验室研究，进行基因表达数据集、模块提取、功能富集分析、蛋白-蛋白相互作用网络构建和 RT-qPCR。此外，通过对福尔马林固定石蜡包埋（FFPE）肿瘤组织中提取的 DNA 进行测序，研究了这些基因的启动子区域突变。结果选择了一个模块作为进一步研究的候选基因。雌激素受体 1（ESR1）和叉头盒 A1（FOXA1）在 PPI 网络中的关联度最高，分别为 9 个和 7 个。此外，与对照组相比，肿瘤组中 FOXA1 基因、线粒体 RNA 处理内切酶 RNA 成分（RMRP）和核富集丰富转录本 1（NEAT1）的表达水平显著上调（依次为 P = 0.044、P = 0.014 和 P = 0.0004）。与阴性转移样本相比，阳性转移患者肿瘤中 NEAT1 和 RMRP 的表达水平明显更高（P < 0.05）。此外，与阴性样本相比，HER2 阳性患者的 RMRP 表达水平大幅下降（P = 0.011）。最后，与正常样本相比，阳性转移样本的启动子测序未发现突变。结论所有三个受检基因的上调水平可能与 BC 的进展相关。因此，它们有可能被用作检测 BC 发展的生物标志物。
{"title":"Evaluation of the Expression Level of Some Coding and Non-coding Genes in Breast Cancer Samples Based on Bioinformatics and Laboratory Studies","authors":"Elmira Rostamnejad, Ronak Rashidi, Zohreh Akbari, M. Maghsoudloo, Mehrdad Hashemi, Amirnader Emami Razavi, M. Entezari, Majid Sadeghizadeh","doi":"10.5812/ijcm-138413","DOIUrl":"https://doi.org/10.5812/ijcm-138413","url":null,"abstract":"Background: Breast cancer (BC) is the leading cause of cancer-associated mortality in women worldwide. However, the molecular mechanism underlying the process is still unclear. In this regard, bioinformatics studies play a decisive role in facilitating the path of biological investigations and can ultimately lead to the identification of better molecular candidates for further study. Objectives: Due to the abnormal expression of many coding and non-coding genes in all types of cancers and their relationship with various mechanisms of carcinogenesis, this study aimed at evaluating the expression levels of certain coding and non-coding genes involved in BC based on bioinformatics findings and laboratory investigations. Methods: Gene expression dataset, module extraction, functional enrichment analysis, protein-protein interaction network construction, and RT-qPCR were performed based on bioinformatics methods and laboratory investigations. Additionally, the promoter region mutations of these genes were investigated, using sequencing of extracted DNAs from formalin-fixed paraffin-embedded (FFPE) tumor tissues. Results: A module was selected as a candidate for further investigation. Estrogen receptor 1 (ESR1) and forkhead box A1 (FOXA1) showed the highest degrees in the PPI network with 9 and 7 links, respectively. Furthermore, the expression levels of the FOXA1 gene, RNA component of mitochondrial RNA processing endoribonuclease (RMRP), and nuclear enriched abundant transcript 1 (NEAT1) were significantly upregulated in the tumor group compared to the control group (in order, P = 0.044, P = 0.014, and P = 0.0004). The tumors of patients with positive metastasis displayed significantly higher levels of NEAT1 and RMRP expression compared to those of negative metastasis samples (P < 0.05). Moreover, the expression level of RMRP dramatically decreased in HER2-positive patients compared to negative samples (P = 0.011). Finally, no mutations were observed in the promoter sequencing of positive metastasis samples compared to normal samples. Conclusions: The upregulation levels of all three examined genes may correlate with BC progression. Therefore, they could potentially be used as biomarkers for detecting BC development.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141007949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryam Samareh Salavati, Shirin Tavakoli, Shima Tavoosi, M. Nodehi, Amir Hossein Baghsheikhi, Mohammad Vaezi, Javad Verdi, S. Rahgozar, M. Barkhordar, Mohamad Ahmadvand
Context: Adoptive T-cell therapy with chimeric antigen receptor (CAR) has shown tremendous progress in hematological cancers. However, some obstacles, such as high price tag, cytokine release syndrome, inability to penetrate solid tumors, and manufacturing complexity limit the wide application of this therapy. Natural killer (NK) cells can kill target cells via mechanisms similar to those of CD8+ cytotoxic T cells; therefore, CAR-NK cell therapy is a promising strategy for cancer treatment. Evidence Acquisition: In this manuscript, all articles published in English regarding CAR-NKs and their application for the treatment of different types of cancers were collected from several databases, including PubMed, Scopus, and Google Scholar, using related keywords such as "Cancer, CAR construction, NK cells, and CAR-NK cells". Results: Compared with CAR-T cells, CAR-NK cells have several advantages, including less toxicity, a high potential opportunity for universal off-the-shelf manufacturing, increased infiltration into solid tumors, overcoming resistant tumor microenvironment, and absence of graft-versus-host disease (GVHD). Conclusions: In this review, we discuss NK cell biology, the source of CAR-NK cells, CAR structure, advances, challenges, and ways to overcome these challenges in CAR-NK cell therapy. Furthermore, we have summarized and highlighted some preclinical and clinical studies in this field.
背景：采用嵌合抗原受体（CAR）的适应性 T 细胞疗法在血液肿瘤方面取得了巨大进展。然而，价格昂贵、细胞因子释放综合征、无法穿透实体瘤以及制造复杂性等障碍限制了这种疗法的广泛应用。自然杀伤（NK）细胞可通过与 CD8+ 细胞毒性 T 细胞相似的机制杀死靶细胞；因此，CAR-NK 细胞疗法是一种很有前景的癌症治疗策略。证据获取：本稿件使用 "癌症、CAR构建、NK细胞和CAR-NK细胞 "等相关关键词，从PubMed、Scopus和Google Scholar等多个数据库中收集了所有关于CAR-NK及其在不同类型癌症治疗中的应用的英文文章。研究结果与CAR-T细胞相比，CAR-NK细胞有几个优点，包括毒性小、通用现货生产的潜在机会大、增加对实体瘤的浸润、克服抗药性肿瘤微环境以及不发生移植物抗宿主病（GVHD）。结论：在这篇综述中，我们讨论了 NK 细胞生物学、CAR-NK 细胞的来源、CAR 结构、CAR-NK 细胞疗法的进展、挑战以及克服这些挑战的方法。此外，我们还总结并强调了该领域的一些临床前和临床研究。
{"title":"CAR-NK Cells as Promising Immune Therapeutics: Platforms and Current Progress","authors":"Maryam Samareh Salavati, Shirin Tavakoli, Shima Tavoosi, M. Nodehi, Amir Hossein Baghsheikhi, Mohammad Vaezi, Javad Verdi, S. Rahgozar, M. Barkhordar, Mohamad Ahmadvand","doi":"10.5812/ijcm-145431","DOIUrl":"https://doi.org/10.5812/ijcm-145431","url":null,"abstract":"Context: Adoptive T-cell therapy with chimeric antigen receptor (CAR) has shown tremendous progress in hematological cancers. However, some obstacles, such as high price tag, cytokine release syndrome, inability to penetrate solid tumors, and manufacturing complexity limit the wide application of this therapy. Natural killer (NK) cells can kill target cells via mechanisms similar to those of CD8+ cytotoxic T cells; therefore, CAR-NK cell therapy is a promising strategy for cancer treatment. Evidence Acquisition: In this manuscript, all articles published in English regarding CAR-NKs and their application for the treatment of different types of cancers were collected from several databases, including PubMed, Scopus, and Google Scholar, using related keywords such as \"Cancer, CAR construction, NK cells, and CAR-NK cells\". Results: Compared with CAR-T cells, CAR-NK cells have several advantages, including less toxicity, a high potential opportunity for universal off-the-shelf manufacturing, increased infiltration into solid tumors, overcoming resistant tumor microenvironment, and absence of graft-versus-host disease (GVHD). Conclusions: In this review, we discuss NK cell biology, the source of CAR-NK cells, CAR structure, advances, challenges, and ways to overcome these challenges in CAR-NK cell therapy. Furthermore, we have summarized and highlighted some preclinical and clinical studies in this field.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141031664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The objective of this study was to utilize random forest methodology to develop a practical diagnostic function for predicting lymph node metastasis in patients diagnosed with breast cancer. Methods: The research data of this retrospective cohort study was obtained through a comprehensive analysis of telephone interviews and medical records of 241 patients with breast cancer referred to the hospitals affiliated with Mazandaran University of Medical Sciences between 2016 and 2022. The data analysis method used in this study was random forest analysis to identify the influential factors associated with lymph node metastasis using R software. Results: The mean age of diagnosis for patients was 52.03 ± 10.932. Based on the random forest analysis outcomes, an accuracy rate of 72.2% has been attained. The influential factors in our study included grade, tubule formation, skin involvement, p53 marker, margin involvement, nuclear pleomorphism, Ki67, tumor location, estrogen receptor (ER), and (progesterone receptor) PR markers. These factors were determined to have a significant impact based on the mean accuracy reduction index. Furthermore, the variables that demonstrated significance based on the mean Gini reduction index included age, grade, tubule formation, tumor size, nuclear pleomorphism, disease level, mitosis, skin involvement, tumor location, and margin involvement. Conclusions: The utilization of the random forest algorithm, which demonstrates a favorable level of discriminative capability, may serve as a suitable approach for predicting metastasis in patients with breast cancer. Furthermore, by identifying these factors, experts can employ effective strategies to mitigate the condition.
{"title":"Predicting Factors Affecting Lymph Node Involvement in Breast Cancer Using Random Forest Approaches","authors":"Fatemeh Zamaninasab, Afsaneh Fendereski, Zahra Zamaninasab, Gholamali Godazandeh, Jamshid Yazdani Charati","doi":"10.5812/ijcm-140283","DOIUrl":"https://doi.org/10.5812/ijcm-140283","url":null,"abstract":"Objectives: The objective of this study was to utilize random forest methodology to develop a practical diagnostic function for predicting lymph node metastasis in patients diagnosed with breast cancer. Methods: The research data of this retrospective cohort study was obtained through a comprehensive analysis of telephone interviews and medical records of 241 patients with breast cancer referred to the hospitals affiliated with Mazandaran University of Medical Sciences between 2016 and 2022. The data analysis method used in this study was random forest analysis to identify the influential factors associated with lymph node metastasis using R software. Results: The mean age of diagnosis for patients was 52.03 ± 10.932. Based on the random forest analysis outcomes, an accuracy rate of 72.2% has been attained. The influential factors in our study included grade, tubule formation, skin involvement, p53 marker, margin involvement, nuclear pleomorphism, Ki67, tumor location, estrogen receptor (ER), and (progesterone receptor) PR markers. These factors were determined to have a significant impact based on the mean accuracy reduction index. Furthermore, the variables that demonstrated significance based on the mean Gini reduction index included age, grade, tubule formation, tumor size, nuclear pleomorphism, disease level, mitosis, skin involvement, tumor location, and margin involvement. Conclusions: The utilization of the random forest algorithm, which demonstrates a favorable level of discriminative capability, may serve as a suitable approach for predicting metastasis in patients with breast cancer. Furthermore, by identifying these factors, experts can employ effective strategies to mitigate the condition.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140678072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Soleimani, N. Masoumi, F. Allameh, Alireza Ghoreifi
{"title":"Tactile Ligation Technique for Renal Vascular Control During Open Radical Nephrectomy","authors":"Mohammad Soleimani, N. Masoumi, F. Allameh, Alireza Ghoreifi","doi":"10.5812/ijcm-142848","DOIUrl":"https://doi.org/10.5812/ijcm-142848","url":null,"abstract":"<jats:p />","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140242179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar Khoshravesh, Malieheh Arab, Nasim Nouri, B. Nouri, Zanbagh Pirastehfar, B. Ghavami
Background: In recent decades, laparoscopy and robotic surgery are mostly used for the treatment of endometrial cancer. Laparoscopic surgery's popularity has grown due to rapid postoperative recovery and reduced post-surgical morbidity and complications compared with open surgery. Objectives: This study aimed to compare laparoscopic surgery and laparotomy in terms of their advantages and disadvantages for treating early-stage endometrial cancer in a population of Iranian patients in a referral center of gyneco-oncology. Methods: In this cohort study at Imam Hossein Medical Center in Tehran, Iran, from 2019 to 2022, early-stage endometrial cancer patients were included. Advanced disease, patients with medical comorbidity not suitable for laparoscopy, previous surgery for endometrial cancer, and prior chemotherapy or radiotherapy for treatment of the endometrial cancer were excluded from the study. The study compared two groups regarding operative findings, including FIGO stage, grade, postoperative complications, and hospitalization days. Results: The study included 17 patients in the laparoscopic group with a mean age of 56(+ 12.5) years old and 44 patients in the laparotomy group with a mean age of 57(+ 10.2) years old. Two groups were well-matched in terms of body mass index and menopausal status. The median intraoperative blood loss was significantly in terms of statistical less in the laparoscopic group (200 ml versus 500 ml, P = 0.001). Four (23.5%) patients in the laparoscopic group needed intraoperative blood transfusion versus 22 (50.0%) in the laparotomy group, P = 0.061. Hospital stay days were shorter in the laparoscopic group, with a median of three versus six days (P < 0.001). Conclusions: In conclusion, the minimally invasive operation caused less blood loss, hospital stay, and blood transfusion in comparison to laparotomy in Iranian endometrial cancer patients, confirming the preferred method of laparoscopy in these patients.
{"title":"A Comparative Cohort Study of Laparoscopy Versus Laparotomy for the Treatment of Iranian Endometrial Cancer Patients","authors":"Sahar Khoshravesh, Malieheh Arab, Nasim Nouri, B. Nouri, Zanbagh Pirastehfar, B. Ghavami","doi":"10.5812/ijcm-141894","DOIUrl":"https://doi.org/10.5812/ijcm-141894","url":null,"abstract":"Background: In recent decades, laparoscopy and robotic surgery are mostly used for the treatment of endometrial cancer. Laparoscopic surgery's popularity has grown due to rapid postoperative recovery and reduced post-surgical morbidity and complications compared with open surgery. Objectives: This study aimed to compare laparoscopic surgery and laparotomy in terms of their advantages and disadvantages for treating early-stage endometrial cancer in a population of Iranian patients in a referral center of gyneco-oncology. Methods: In this cohort study at Imam Hossein Medical Center in Tehran, Iran, from 2019 to 2022, early-stage endometrial cancer patients were included. Advanced disease, patients with medical comorbidity not suitable for laparoscopy, previous surgery for endometrial cancer, and prior chemotherapy or radiotherapy for treatment of the endometrial cancer were excluded from the study. The study compared two groups regarding operative findings, including FIGO stage, grade, postoperative complications, and hospitalization days. Results: The study included 17 patients in the laparoscopic group with a mean age of 56(+ 12.5) years old and 44 patients in the laparotomy group with a mean age of 57(+ 10.2) years old. Two groups were well-matched in terms of body mass index and menopausal status. The median intraoperative blood loss was significantly in terms of statistical less in the laparoscopic group (200 ml versus 500 ml, P = 0.001). Four (23.5%) patients in the laparoscopic group needed intraoperative blood transfusion versus 22 (50.0%) in the laparotomy group, P = 0.061. Hospital stay days were shorter in the laparoscopic group, with a median of three versus six days (P < 0.001). Conclusions: In conclusion, the minimally invasive operation caused less blood loss, hospital stay, and blood transfusion in comparison to laparotomy in Iranian endometrial cancer patients, confirming the preferred method of laparoscopy in these patients.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140253229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nazanin Azmi-Naei, A. Ghanbari-Motlagh, A. Ostovar, Yousef Moradi, Mohsen Asadi-Lari
Background: Colorectal cancer is one of the top 5 common cancers in Iran with over 1.9 million new cases. Completeness of pathology reports is one of the key factors of cancer care management. So, sufficient reporting of pathological factors is vital for optimum diagnosis, projection of prognosis and patient care. Objectives: To support epidemiological research, we determined the completeness of colorectal cancer pathology reports at the nationwide level. Methods: Accessing to the text of pathology reports from a web-based application that was created by the Iranian National Population-Based Cancer Registry (INPCR) was considered the most complete and reliable. We requested that the INPCR extracts their pathology records for manual review for colorectal cancer (ICD-10 code ‘C18’, ‘C19’, ‘C20’, and 'C21'). Results: Exclusion criteria were applied and 2092 pathology reports were analyzed. The mean age of patients was 61 years; 56% were male. A vast number of colorectal cancer cases were at T3-stage (colon 68.4%, rectal 58.6%) and N0-stage (colon 55.7%, rectal 57%). Information on key prognostic factors, such as lymphovascular and perineural was frequently lacking (22.7% and 35.7% missing, respectively). On the other hand, Tumor type and tumor grade had a high percentage of reporting (100% and 100%, respectively). In addition, our study revealed a low rate of overall complete reporting (colon 0.2%, rectal 1.1%). Conclusions: Optimum diagnosis, prediction of prognosis, and patient care require sufficient reporting of pathological factors, so efforts should be made to improve the reporting of overall pathology factors of Colorectal cancer (CRC).
{"title":"Completeness of Colorectal Cancer Pathology Reports in Iranian National Population-Based Cancer Registry System","authors":"Nazanin Azmi-Naei, A. Ghanbari-Motlagh, A. Ostovar, Yousef Moradi, Mohsen Asadi-Lari","doi":"10.5812/ijcm-137805","DOIUrl":"https://doi.org/10.5812/ijcm-137805","url":null,"abstract":"Background: Colorectal cancer is one of the top 5 common cancers in Iran with over 1.9 million new cases. Completeness of pathology reports is one of the key factors of cancer care management. So, sufficient reporting of pathological factors is vital for optimum diagnosis, projection of prognosis and patient care. Objectives: To support epidemiological research, we determined the completeness of colorectal cancer pathology reports at the nationwide level. Methods: Accessing to the text of pathology reports from a web-based application that was created by the Iranian National Population-Based Cancer Registry (INPCR) was considered the most complete and reliable. We requested that the INPCR extracts their pathology records for manual review for colorectal cancer (ICD-10 code ‘C18’, ‘C19’, ‘C20’, and 'C21'). Results: Exclusion criteria were applied and 2092 pathology reports were analyzed. The mean age of patients was 61 years; 56% were male. A vast number of colorectal cancer cases were at T3-stage (colon 68.4%, rectal 58.6%) and N0-stage (colon 55.7%, rectal 57%). Information on key prognostic factors, such as lymphovascular and perineural was frequently lacking (22.7% and 35.7% missing, respectively). On the other hand, Tumor type and tumor grade had a high percentage of reporting (100% and 100%, respectively). In addition, our study revealed a low rate of overall complete reporting (colon 0.2%, rectal 1.1%). Conclusions: Optimum diagnosis, prediction of prognosis, and patient care require sufficient reporting of pathological factors, so efforts should be made to improve the reporting of overall pathology factors of Colorectal cancer (CRC).","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140254081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Solmaz Taheri, M. Akbari, Aliakbar Khadem Maboudi, A. Baghestani
Background: The analysis methods for breast cancer (BC) data have also advanced alongside medical advancements in the treatment of the disease. Objectives: This study tried to investigate the factors affecting the survival rate of BC patients using the cured model based on Kumaraswamy's defective distribution. Methods: A retrospective study collected data on 2 574 BC patients between September 2013 and September 2020, including demographic, clinicopathological, and biological characteristics. The best model for predicting cure was chosen based on AIC. Results: The selected cure model revealed that age (P = 0.046), tumor histologic grade (P = 0.0.38), tumor size (P = 0.0.41), HER2 status (P = 0.001), KI67 levels (P = 0.027), P53 status (P = 0.029), and hormone therapy (P = 0.039) were significant variables. The estimated cured rate of this data was 0.82. Conclusions: Considering that the advanced cured model has the highest accuracy in identifying the factors affecting the survival rate of BC patients and more risk factors have become significant in this model, it is recommended to pay special attention to patients aged over 60 with poorly differentiated historical grade, T3 tumor size, HER2 positive status, KI67 levels below 20%, negative P53 status, and no hormone therapy received in the process of disease prognosis.
{"title":"Investigating the Risk Factors Affecting the Survival Rate of Breast Cancer Patients Using Cured Model Based on Defective Distribution","authors":"Solmaz Taheri, M. Akbari, Aliakbar Khadem Maboudi, A. Baghestani","doi":"10.5812/ijcm-139947","DOIUrl":"https://doi.org/10.5812/ijcm-139947","url":null,"abstract":"Background: The analysis methods for breast cancer (BC) data have also advanced alongside medical advancements in the treatment of the disease. Objectives: This study tried to investigate the factors affecting the survival rate of BC patients using the cured model based on Kumaraswamy's defective distribution. Methods: A retrospective study collected data on 2 574 BC patients between September 2013 and September 2020, including demographic, clinicopathological, and biological characteristics. The best model for predicting cure was chosen based on AIC. Results: The selected cure model revealed that age (P = 0.046), tumor histologic grade (P = 0.0.38), tumor size (P = 0.0.41), HER2 status (P = 0.001), KI67 levels (P = 0.027), P53 status (P = 0.029), and hormone therapy (P = 0.039) were significant variables. The estimated cured rate of this data was 0.82. Conclusions: Considering that the advanced cured model has the highest accuracy in identifying the factors affecting the survival rate of BC patients and more risk factors have become significant in this model, it is recommended to pay special attention to patients aged over 60 with poorly differentiated historical grade, T3 tumor size, HER2 positive status, KI67 levels below 20%, negative P53 status, and no hormone therapy received in the process of disease prognosis.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140081144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pain has been known as one of the most common, persistent, and complex symptoms of patients with lung cancer. Objectives: The aim of this research is to study the relationship between attitude to pain and the prevalence and method of pain control in patients with lung cancer. Methods: This descriptive cross-sectional study was performed through the census method in patients suffering from lung cancer in Ilam Province. For data collection, while interviewing the patients and studying their files, instruments were used including demographic characteristics form, brief pain inventory, and pain attitude questionnaire. Data analysis was performed by SPSS v.16 through descriptive statistical tests (mean, percentage, and standard deviation) and analytical tests (independent t-test, ANOVA, and linear regression). Results: Considering the severity of pain, 12 (18.8%) patients had mild pain, 43 (67.2%) had moderate pain, and 9 (14.1%) had severe pain, and all of them reported some degree of pain. According to the findings, mean ± SD of the total score of the questionnaire was 77.15 (3.18), where the minimum and maximum acquired scores were 72 and 85, respectively. Also, no significant relationship was found between any of the dimensions of the attitude to pain questionnaire and the severity of pain. Further the mean ± SD of attitude to pain was 76.58 (2.81), 77.09 (3.28), and 78.22 (3.23) for mild, moderate, and severe pain, respectively. Conclusions: In this study, there was no relationship between pain severity and attitude to pain, which may have been due to the small sample size or the specificity of the study in the group of lung cancer patients. Accordingly, conducting further studies in this regard with a larger sample size is suggested.
{"title":"Prevalence of Pain and Factors Affecting it in Patients with Lung Cancer in Ilam","authors":"Elham Bastani, Mahsa Rizehbandi, F. Shokri","doi":"10.5812/ijcm-136637","DOIUrl":"https://doi.org/10.5812/ijcm-136637","url":null,"abstract":"Background: Pain has been known as one of the most common, persistent, and complex symptoms of patients with lung cancer. Objectives: The aim of this research is to study the relationship between attitude to pain and the prevalence and method of pain control in patients with lung cancer. Methods: This descriptive cross-sectional study was performed through the census method in patients suffering from lung cancer in Ilam Province. For data collection, while interviewing the patients and studying their files, instruments were used including demographic characteristics form, brief pain inventory, and pain attitude questionnaire. Data analysis was performed by SPSS v.16 through descriptive statistical tests (mean, percentage, and standard deviation) and analytical tests (independent t-test, ANOVA, and linear regression). Results: Considering the severity of pain, 12 (18.8%) patients had mild pain, 43 (67.2%) had moderate pain, and 9 (14.1%) had severe pain, and all of them reported some degree of pain. According to the findings, mean ± SD of the total score of the questionnaire was 77.15 (3.18), where the minimum and maximum acquired scores were 72 and 85, respectively. Also, no significant relationship was found between any of the dimensions of the attitude to pain questionnaire and the severity of pain. Further the mean ± SD of attitude to pain was 76.58 (2.81), 77.09 (3.28), and 78.22 (3.23) for mild, moderate, and severe pain, respectively. Conclusions: In this study, there was no relationship between pain severity and attitude to pain, which may have been due to the small sample size or the specificity of the study in the group of lung cancer patients. Accordingly, conducting further studies in this regard with a larger sample size is suggested.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140433741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Renal cell carcinoma (RCC) is an aggressive cancer prevalent worldwide. Objectives: We investigated whether preoperative serum levels of plateletcrit (PCT) can predict tumor stages and pathological grades in patients, who were operated on for T1 - 4, N0, and M0 RCC. Additionally, we compared it with neutrophil to lymphocyte ratio (NLR). Methods: We conducted a retrospective evaluation of 196 patients, who had undergone nephrectomy (radical or partial) for T1 v- 4, N0, and M0 RCC at our hospital from January 2016 to December 2022. Based on their histopathology results, tumor stages (T) and WHO-ISUP grades (G) were identified. The patients were separated into two categories depending on their T-stage (T1 - T2 and T3 - T4) and pathological grade (G1 - 2 and G3 - 4). The study compared the NLR, PCT, and their combined values to determine their role in predicting aggressiveness based on pathological stage and grade of tumors. Results: The mean cut-off values for NLR and PCT were found to be 2.108 and 0.273, for the high tumor stage and 2.237 and 0.252 for high-grade tumors, respectively. The statistical analysis showed that NLR (P = 0.031) and PCT (P = 0.006) were significant predictors of high tumor stage, while only PCT (P = 0.022) was a significant predictor of high WHO-ISUP grade. The combination of both NLR and PCT helps improve the sensitivity for detecting high-grade tumors. Conclusions: NLR and PCT can be predictive markers of the tumor stage. However, only PCT can predict the tumor grade in patients with RCC. In addition, combining the PCT and NLR scores improved the predictive ability of each parameter, especially for identifying high-grade tumors.
{"title":"Pre-operative Plateletcrit vs. Neutrophil to Lymphocyte Ratio in Predicting Biological Tumor Behavior in Patients with T1 - 4, N0, M0 Renal Cell Carcinoma: A Retrospective Analysis","authors":"Surag Kr, A. Choudhary, Anshuman Singh, Swathi Pm, Kasi Vishwanath, Mithun Rao","doi":"10.5812/ijcm-140832","DOIUrl":"https://doi.org/10.5812/ijcm-140832","url":null,"abstract":"Background: Renal cell carcinoma (RCC) is an aggressive cancer prevalent worldwide. Objectives: We investigated whether preoperative serum levels of plateletcrit (PCT) can predict tumor stages and pathological grades in patients, who were operated on for T1 - 4, N0, and M0 RCC. Additionally, we compared it with neutrophil to lymphocyte ratio (NLR). Methods: We conducted a retrospective evaluation of 196 patients, who had undergone nephrectomy (radical or partial) for T1 v- 4, N0, and M0 RCC at our hospital from January 2016 to December 2022. Based on their histopathology results, tumor stages (T) and WHO-ISUP grades (G) were identified. The patients were separated into two categories depending on their T-stage (T1 - T2 and T3 - T4) and pathological grade (G1 - 2 and G3 - 4). The study compared the NLR, PCT, and their combined values to determine their role in predicting aggressiveness based on pathological stage and grade of tumors. Results: The mean cut-off values for NLR and PCT were found to be 2.108 and 0.273, for the high tumor stage and 2.237 and 0.252 for high-grade tumors, respectively. The statistical analysis showed that NLR (P = 0.031) and PCT (P = 0.006) were significant predictors of high tumor stage, while only PCT (P = 0.022) was a significant predictor of high WHO-ISUP grade. The combination of both NLR and PCT helps improve the sensitivity for detecting high-grade tumors. Conclusions: NLR and PCT can be predictive markers of the tumor stage. However, only PCT can predict the tumor grade in patients with RCC. In addition, combining the PCT and NLR scores improved the predictive ability of each parameter, especially for identifying high-grade tumors.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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