Aida Abbasi, Javid Sadri Nahand, Mohsen Moghoofei, Maryam Esghaei, D. Javanmard, M. H. Karbalaie Niya, Farzin Sadeghi, F. Bokharaei-Salim, M. Karimzadeh, A. Khodayari, H. Keyvani
Background: Brain tumors are all primary central nervous system (CNS) tumors with unclear etiologies and viral infections, especially human herpesviruses, which have emerged as a hot topic for comprehensive research. Objectives: The present study aimed at assessing the molecular epidemiology of varicella-zoster virus (VZV) and its association with microRNA 122 (miR-122) expression in CNS tumor samples. Methods: Fresh frozen tissue samples were collected from 60 CNS tumor patients and 45 healthy controls. A nested PCR assay was performed to detect the VZV-DNA. Subsequently, the expression level of miR-122 was evaluated in the CNS tumor tissue samples of patients and the brain tissue samples were obtained from healthy controls, using a real-time PCR assay. Results: Of 60 patients with CNS tumors, 29 were men and 31 were women. VZV-DNA was detected in 13.3% of the CNS tumor tissue specimens. There was no statistically significant association between the presence of VZV-DNA and different types of CNS tumors (P > 0.05). Furthermore, the expression level of miR-122 was significantly downregulated in the CNS tumor tissue samples obtained from the patients compared with those of the healthy controls (P < 0.05). Additionally, the expression level of miR-122 was significantly lower in the VZV-positive tumor samples as compared with those of the VZV-negative tumor samples and the healthy controls. Conclusions: Although VZV plays no direct role in the development of CNS tumors, the virus may affect the biology of CNS tumors by decreasing the expression levels of miR-122, which consequently leads to an increased risk of malignancy. However, the experimental data are not conclusive enough; so, further investigations are needed.
{"title":"Evaluation of Cellular miR-122 Expression in Association with the Presence of Varicella-Zoster Virus among Central Nervous System Tumors","authors":"Aida Abbasi, Javid Sadri Nahand, Mohsen Moghoofei, Maryam Esghaei, D. Javanmard, M. H. Karbalaie Niya, Farzin Sadeghi, F. Bokharaei-Salim, M. Karimzadeh, A. Khodayari, H. Keyvani","doi":"10.5812/ijcm-108497","DOIUrl":"https://doi.org/10.5812/ijcm-108497","url":null,"abstract":"Background: Brain tumors are all primary central nervous system (CNS) tumors with unclear etiologies and viral infections, especially human herpesviruses, which have emerged as a hot topic for comprehensive research. Objectives: The present study aimed at assessing the molecular epidemiology of varicella-zoster virus (VZV) and its association with microRNA 122 (miR-122) expression in CNS tumor samples. Methods: Fresh frozen tissue samples were collected from 60 CNS tumor patients and 45 healthy controls. A nested PCR assay was performed to detect the VZV-DNA. Subsequently, the expression level of miR-122 was evaluated in the CNS tumor tissue samples of patients and the brain tissue samples were obtained from healthy controls, using a real-time PCR assay. Results: Of 60 patients with CNS tumors, 29 were men and 31 were women. VZV-DNA was detected in 13.3% of the CNS tumor tissue specimens. There was no statistically significant association between the presence of VZV-DNA and different types of CNS tumors (P > 0.05). Furthermore, the expression level of miR-122 was significantly downregulated in the CNS tumor tissue samples obtained from the patients compared with those of the healthy controls (P < 0.05). Additionally, the expression level of miR-122 was significantly lower in the VZV-positive tumor samples as compared with those of the VZV-negative tumor samples and the healthy controls. Conclusions: Although VZV plays no direct role in the development of CNS tumors, the virus may affect the biology of CNS tumors by decreasing the expression levels of miR-122, which consequently leads to an increased risk of malignancy. However, the experimental data are not conclusive enough; so, further investigations are needed.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"63 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76040825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad R Mafi, Shima Azimi Oliaei, R. Heshmat, H. Yahyazadeh, Ali Motlagh
Background: In Iran, the incidence of colorectal cancer has been increasing over the last 25 years. Although left-sided colon cancers are still more common, several studies in recent years have shown a shift toward right colon. This rightward shift could have important clinical and healthcare consequences, as right-sided tumors generally have poorer prognoses compared to left-sided tumors and besides, are more likely to be missed in screening colonoscopy. Objectives: This retrospective study aimed at describing the demographic and clinicopathologic characteristics of patients with colon cancer based on tumor sidedness in two referral hospitals in Tehran. Methods: Data of the patients with colon cancer who had been treated from 2010 to 2020 in two referral hospitals in Tehran, Iran were retrospectively reviewed. Collected data included patients’ demographics, tumor histology and differentiation, tumor location, stage, and disease-free survival (DFS). Results: A total of 1535 cases entered the study including 849 (55.3%) males and 686 (44.7%) females with a mean age of 58.22 years (range: 22 - 89). Regarding the sidedness, 800 (52.1%) had left-sided and 735 (47.9%) had right-sided tumors. Although there were more cases of left-sided tumors compared to right-sided ones on total, there existed a trend toward shifting to the right side, which was statistically significant. There existed more cases of poorly differentiated tumors in the right side and besides, right-sided tumors had poorer DFS compared to the left-sided tumors (68.3% vs 78.3%). Conclusions: Left and right colon tumors differ in molecular mechanisms involved in tumorigenesis. These differences in epidemiological, molecular and histological parameters can have clinical implications. Tumor-sidedness should be acknowledged as an important epidemiological parameter with significant impacts on screening, tumorgenesis, response to treatment, and prognosis.
背景:在伊朗，结直肠癌的发病率在过去的25年里一直在增加。尽管左结肠癌仍然更常见，但近年来的几项研究表明，右结肠癌的发病率正在转变。这种向右转移可能具有重要的临床和医疗保健后果，因为右侧肿瘤通常比左侧肿瘤预后较差，而且在结肠镜检查中更容易被遗漏。目的:本回顾性研究旨在描述在德黑兰两家转诊医院肿瘤侧方基础上的结肠癌患者的人口学和临床病理特征。方法:回顾性分析伊朗德黑兰两家转诊医院2010 ~ 2020年收治的结肠癌患者资料。收集的数据包括患者的人口统计学、肿瘤组织学和分化、肿瘤位置、分期和无病生存期(DFS)。结果:共入组病例1535例，其中男性849例(55.3%)，女性686例(44.7%)，平均年龄58.22岁(22 ~ 89岁)。侧边性方面，左侧肿瘤800例(52.1%)，右侧肿瘤735例(47.9%)。虽然总体上左侧肿瘤多于右侧肿瘤，但有向右侧转移的趋势，具有统计学意义。右侧低分化肿瘤较多，且右侧肿瘤的DFS较左侧肿瘤差(68.3% vs 78.3%)。结论:左、右结肠肿瘤发生的分子机制不同。这些流行病学、分子和组织学参数的差异可能具有临床意义。肿瘤侧性是一个重要的流行病学参数，对筛查、肿瘤发生、治疗反应和预后有重要影响。
{"title":"Anatomical Distribution of Colon Cancer: A Retrospective 10-year Study to Evaluate Rightward Shift in Two Referral Hospitals in Iran","authors":"Ahmad R Mafi, Shima Azimi Oliaei, R. Heshmat, H. Yahyazadeh, Ali Motlagh","doi":"10.5812/ijcm-128897","DOIUrl":"https://doi.org/10.5812/ijcm-128897","url":null,"abstract":"Background: In Iran, the incidence of colorectal cancer has been increasing over the last 25 years. Although left-sided colon cancers are still more common, several studies in recent years have shown a shift toward right colon. This rightward shift could have important clinical and healthcare consequences, as right-sided tumors generally have poorer prognoses compared to left-sided tumors and besides, are more likely to be missed in screening colonoscopy. Objectives: This retrospective study aimed at describing the demographic and clinicopathologic characteristics of patients with colon cancer based on tumor sidedness in two referral hospitals in Tehran. Methods: Data of the patients with colon cancer who had been treated from 2010 to 2020 in two referral hospitals in Tehran, Iran were retrospectively reviewed. Collected data included patients’ demographics, tumor histology and differentiation, tumor location, stage, and disease-free survival (DFS). Results: A total of 1535 cases entered the study including 849 (55.3%) males and 686 (44.7%) females with a mean age of 58.22 years (range: 22 - 89). Regarding the sidedness, 800 (52.1%) had left-sided and 735 (47.9%) had right-sided tumors. Although there were more cases of left-sided tumors compared to right-sided ones on total, there existed a trend toward shifting to the right side, which was statistically significant. There existed more cases of poorly differentiated tumors in the right side and besides, right-sided tumors had poorer DFS compared to the left-sided tumors (68.3% vs 78.3%). Conclusions: Left and right colon tumors differ in molecular mechanisms involved in tumorigenesis. These differences in epidemiological, molecular and histological parameters can have clinical implications. Tumor-sidedness should be acknowledged as an important epidemiological parameter with significant impacts on screening, tumorgenesis, response to treatment, and prognosis.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"4 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73844415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hadi Chenaneh, Mojtaba Rashidi, K. Ahmadi Angali, M. Adelipour
Background: Since breast cancer is the most common type of cancer in women around the world, finding new biomarkers for early diagnosis of breast cancer is invaluable. Objectives: This research assessed the mRNA expression of triggering receptors expressed on myeloid cell 2 (TREM2) and tandem C2 domains nuclear protein (TC2N) genes among Iranian patients with breast cancer. Methods: We acquired 50 samples of cancerous breast tumors and corresponding adjacent non-cancerous tissues from Iranian women. The gene expression of TREM2 and TC2N was measured by quantitative real-time polymerase chain reaction (q-RT-PCR). In addition, the association between TREM2 and TC2N levels with various clinicopathologic characteristics was also investigated. Results: The increased levels of TREM2 and TC2N mRNAs were shown in breast cancerous tissues in comparison with adjacent non-cancerous tissues (P < 0.05). Among the clinicopathological characteristics evaluated, tumor size, necrosis, and lymphatic tissue invasion were significantly associated with high TREM2 expression. A significant relationship was also seen between increased TC2N expression and tumor grade. Sensitivity and specificity were shown at 84% and 94%, respectively, for TREM2 and 72% and 100% for TC2N. Conclusions: The data suggest that TREM2 expression, but not TC2N, could be a suitable biomarker for breast cancer diagnosis.
{"title":"Expression Analysis of TREM2 and TC2N Genes in Human Breast Cancer Tissues","authors":"Hadi Chenaneh, Mojtaba Rashidi, K. Ahmadi Angali, M. Adelipour","doi":"10.5812/ijcm-127489","DOIUrl":"https://doi.org/10.5812/ijcm-127489","url":null,"abstract":"Background: Since breast cancer is the most common type of cancer in women around the world, finding new biomarkers for early diagnosis of breast cancer is invaluable. Objectives: This research assessed the mRNA expression of triggering receptors expressed on myeloid cell 2 (TREM2) and tandem C2 domains nuclear protein (TC2N) genes among Iranian patients with breast cancer. Methods: We acquired 50 samples of cancerous breast tumors and corresponding adjacent non-cancerous tissues from Iranian women. The gene expression of TREM2 and TC2N was measured by quantitative real-time polymerase chain reaction (q-RT-PCR). In addition, the association between TREM2 and TC2N levels with various clinicopathologic characteristics was also investigated. Results: The increased levels of TREM2 and TC2N mRNAs were shown in breast cancerous tissues in comparison with adjacent non-cancerous tissues (P < 0.05). Among the clinicopathological characteristics evaluated, tumor size, necrosis, and lymphatic tissue invasion were significantly associated with high TREM2 expression. A significant relationship was also seen between increased TC2N expression and tumor grade. Sensitivity and specificity were shown at 84% and 94%, respectively, for TREM2 and 72% and 100% for TC2N. Conclusions: The data suggest that TREM2 expression, but not TC2N, could be a suitable biomarker for breast cancer diagnosis.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"141 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79205349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parisa Kiani Amin, Siamak Mashhady Rafie, S. Hesaraki, K. Amini
Background: Doxorubicin is preferred to cure many malignancies. Its nephrotoxicity is a dangerous nature that is to operate with a warning. Antioxidants accompanied by anticancer could moderate the various side effects. Objectives: Cichorium intybus (C. intybus) has nephron-protective effects. Melatonin stands as an antioxidant equivalent to others. The repairing effects of C. intybus-melatonin against the toxicity effects of doxorubicin on the kidneys were studied. Methods: Thirty 20 g to 25 g, balb/c mice were divided into 5 identical groups (n: 6). The research was grouped as control saline; DOX with the injection of doxorubicin; Chicory with the administration of the C. intybus complete extract following DOX; melatonin with the administration of the melatonin following DOX; both: with the administration of the chicory and melatonin following DOX. The histopathological study was set to determine degeneration, inflammation, and necrosis. Results: The mean of each histological phenomenon in the control group was significantly lower than in the DOX group. In the histopathology, we saw that all the treating groups, including C. intybus extract-received, melatonin-received, both of them received improved better than the doxorubicin-received group. The best improving mean was seen in the latter group. The DOX-induced nephrotoxicity could be improved by using the C. intybus extract and melatonin synchronously as therapeutic care. Conclusions: Synchronous administration of the chicory and melatonin has a healing potency against doxorubicin-induced nephrotoxicity.
背景:阿霉素是治疗许多恶性肿瘤的首选药物。它的肾毒性是一种危险的性质，需要警告操作。抗氧化剂与抗癌药物相结合，可以减轻各种副作用。目的:菊苣具有肾保护作用。褪黑素和其他抗氧化剂一样。研究了虫草褪黑素对阿霉素肾毒性的修复作用。方法:30只20 g ~ 25 g的balb/c小鼠随机分为5组(n: 6)，实验组为对照生理盐水;DOX配合阿霉素注射液;菊苣经DOX处理后给予菊苣全提取物;褪黑素与在DOX后给予褪黑素;两者:在DOX后给予菊苣和褪黑素。组织病理学研究确定变性、炎症和坏死。结果:对照组各组织学现象的平均值均显著低于DOX组。在组织病理学上，我们看到所有的治疗组，包括接受虫草提取物、褪黑素的治疗组，他们的治疗效果都比接受阿霉素的治疗组好。后一组的平均改善效果最好。同时使用青虫草提取物和褪黑素作为治疗护理，可改善dox引起的肾毒性。结论:菊苣和褪黑素同步给药对阿霉素引起的肾毒性具有愈合效力。
{"title":"Antioxidant Activity of Cichorium intybus Extract in Concomitant Use with Melatonin Against Doxorubicin-induced Nephrotoxicity","authors":"Parisa Kiani Amin, Siamak Mashhady Rafie, S. Hesaraki, K. Amini","doi":"10.5812/ijcm-127863","DOIUrl":"https://doi.org/10.5812/ijcm-127863","url":null,"abstract":"Background: Doxorubicin is preferred to cure many malignancies. Its nephrotoxicity is a dangerous nature that is to operate with a warning. Antioxidants accompanied by anticancer could moderate the various side effects. Objectives: Cichorium intybus (C. intybus) has nephron-protective effects. Melatonin stands as an antioxidant equivalent to others. The repairing effects of C. intybus-melatonin against the toxicity effects of doxorubicin on the kidneys were studied. Methods: Thirty 20 g to 25 g, balb/c mice were divided into 5 identical groups (n: 6). The research was grouped as control saline; DOX with the injection of doxorubicin; Chicory with the administration of the C. intybus complete extract following DOX; melatonin with the administration of the melatonin following DOX; both: with the administration of the chicory and melatonin following DOX. The histopathological study was set to determine degeneration, inflammation, and necrosis. Results: The mean of each histological phenomenon in the control group was significantly lower than in the DOX group. In the histopathology, we saw that all the treating groups, including C. intybus extract-received, melatonin-received, both of them received improved better than the doxorubicin-received group. The best improving mean was seen in the latter group. The DOX-induced nephrotoxicity could be improved by using the C. intybus extract and melatonin synchronously as therapeutic care. Conclusions: Synchronous administration of the chicory and melatonin has a healing potency against doxorubicin-induced nephrotoxicity.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"10 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79993751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Shiravani, M. Robati, Ali Ariafar, A. Safaei, Mojgan Hajisafari Tafti, Shaghayegh Moradi Alamdarloo
Introduction: Primary malignant melanomas (MM) of the female urogenital tract are extremely rare and aggressive neoplasms. The majority of these neoplasms occur in postmenopausal women, originate from the vulva and vagina, and involvement of the uterus, cervix, and ovary is exceedingly uncommon. Case Presentation: We presented a patient with MM of the uterine cervix, first diagnosed with a punch biopsy of the lesion, which was distributed from the cervical mass to the vestibule and labia minor. She underwent anterior pelvic exenteration. Pathology evaluation revealed primary MM of uterine cervix in FIGO stage III. She received adjuvant treatment with radiation and immunotherapy. On her fallow up 1 year after her disease diagnosis, she is still alive without evidence of distant metastasis. Conclusions: When feasible, pelvic exenteration offers appropriate initial management in cervical MM.
{"title":"Primary Malignant Melanoma of Uterine Cervix with Disseminated Involvement of Lower Genitourinary Tract","authors":"Z. Shiravani, M. Robati, Ali Ariafar, A. Safaei, Mojgan Hajisafari Tafti, Shaghayegh Moradi Alamdarloo","doi":"10.5812/ijcm-114156","DOIUrl":"https://doi.org/10.5812/ijcm-114156","url":null,"abstract":"Introduction: Primary malignant melanomas (MM) of the female urogenital tract are extremely rare and aggressive neoplasms. The majority of these neoplasms occur in postmenopausal women, originate from the vulva and vagina, and involvement of the uterus, cervix, and ovary is exceedingly uncommon. Case Presentation: We presented a patient with MM of the uterine cervix, first diagnosed with a punch biopsy of the lesion, which was distributed from the cervical mass to the vestibule and labia minor. She underwent anterior pelvic exenteration. Pathology evaluation revealed primary MM of uterine cervix in FIGO stage III. She received adjuvant treatment with radiation and immunotherapy. On her fallow up 1 year after her disease diagnosis, she is still alive without evidence of distant metastasis. Conclusions: When feasible, pelvic exenteration offers appropriate initial management in cervical MM.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"10 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78358849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Eslami, Z. Jamali, H. Babaei, Vahid Fakhrzadeh, Javad Ahamdi, F. Tavakoli
Background: Mucositis is one of the most important complications of radiotherapy. Some factors such as type of treatment and degree of patient sensitivity affect mucositis occurrence. Objective: This research was implemented to evaluate the effect of grape seed extract on radiation-induced mucositis. Methods: This research is a double-blinded randomized clinical trial implemented on 78 patients undergoing head and neck radiotherapy in the oncology ward of Imam Reza Hospital of Tabriz. The patients were randomly divided into 2 groups, the intervention, and the control group. Each group included 39 patients. The intervention group used 2% grape seed extract mouthwashes and the control group used placebo mouthwashes. The mouthwashes were used 3 times a day for 2 weeks. For statistical analysis of collected data, SPSS 20 software was applied. Results: The results showed that according to the Friedman test, on the 10th and 14th days, mucositis grade and incidence had a significant difference between the intervention and control groups. Conclusions: The findings indicated that grape seed extract mouthwash in preventing radiation-induced mucositis was more effective than a placebo. Thus, this agent can be recommended as an appropriate medication to eliminate oral mucositis symptoms.
{"title":"Evaluation of the Effect of Grape Seed Extract (GSE) on Oral Mucositis in Patients with Head and Neck Radiotherapy History- A Randomized Clinical Trial","authors":"H. Eslami, Z. Jamali, H. Babaei, Vahid Fakhrzadeh, Javad Ahamdi, F. Tavakoli","doi":"10.5812/ijcm-130603","DOIUrl":"https://doi.org/10.5812/ijcm-130603","url":null,"abstract":"Background: Mucositis is one of the most important complications of radiotherapy. Some factors such as type of treatment and degree of patient sensitivity affect mucositis occurrence. Objective: This research was implemented to evaluate the effect of grape seed extract on radiation-induced mucositis. Methods: This research is a double-blinded randomized clinical trial implemented on 78 patients undergoing head and neck radiotherapy in the oncology ward of Imam Reza Hospital of Tabriz. The patients were randomly divided into 2 groups, the intervention, and the control group. Each group included 39 patients. The intervention group used 2% grape seed extract mouthwashes and the control group used placebo mouthwashes. The mouthwashes were used 3 times a day for 2 weeks. For statistical analysis of collected data, SPSS 20 software was applied. Results: The results showed that according to the Friedman test, on the 10th and 14th days, mucositis grade and incidence had a significant difference between the intervention and control groups. Conclusions: The findings indicated that grape seed extract mouthwash in preventing radiation-induced mucositis was more effective than a placebo. Thus, this agent can be recommended as an appropriate medication to eliminate oral mucositis symptoms.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"201 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72838006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shabnam Khalilnezhad, R. Safaralizadeh, Mohammad Ali Hosseini PourFeizi, Ahad Khalilnezhad, D. Amani
Background: Controversial evidence exists regarding the metastasis-suppressor or promoting activity of motility-related protein-1 (MRP-1/CD9) in breast cancer (BC). Objectives: we aimed at investigating the possible correlation of CD9 with a metastasis marker matrix metalloproteinase 9 (MMP9) in human BC tissues. Methods: A total of 19 BC and 5 normal breast tissues were analyzed. The mRNA expression of CD9 and MMP9 was measured by quantitative PCR. The correlation of genes’ expression with each other and clinicopathological features (i. e. tumor pathology, grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), P53, and KI67) was tested by relevant statistical analysis methods. Results: There was no significant difference between patients with BC and the control group regarding the expression of MMP9 (P = 0.394) and CD9 (P = 0.887). A significant strong positive correlation was observed between CD9 and MMP-9 expressions (r = 0.761 and P = 0.0002). The MMP9 expression was significantly higher in ER or PR positive compared to ER or PR negative tumors (P = 0.046). Conclusions: Given the strong correlation with MMP9, it seems that CD9 might have a role in metastasis in human BC. However, much more studies are required to further support this hypothesis.
{"title":"Co-expression of Matrix Metalloproteinase 9 (MMP9) and Motility-related Protein-1 (MRP-1/CD9) in Human Breast Cancer","authors":"Shabnam Khalilnezhad, R. Safaralizadeh, Mohammad Ali Hosseini PourFeizi, Ahad Khalilnezhad, D. Amani","doi":"10.5812/ijcm-105009","DOIUrl":"https://doi.org/10.5812/ijcm-105009","url":null,"abstract":"Background: Controversial evidence exists regarding the metastasis-suppressor or promoting activity of motility-related protein-1 (MRP-1/CD9) in breast cancer (BC). Objectives: we aimed at investigating the possible correlation of CD9 with a metastasis marker matrix metalloproteinase 9 (MMP9) in human BC tissues. Methods: A total of 19 BC and 5 normal breast tissues were analyzed. The mRNA expression of CD9 and MMP9 was measured by quantitative PCR. The correlation of genes’ expression with each other and clinicopathological features (i. e. tumor pathology, grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), P53, and KI67) was tested by relevant statistical analysis methods. Results: There was no significant difference between patients with BC and the control group regarding the expression of MMP9 (P = 0.394) and CD9 (P = 0.887). A significant strong positive correlation was observed between CD9 and MMP-9 expressions (r = 0.761 and P = 0.0002). The MMP9 expression was significantly higher in ER or PR positive compared to ER or PR negative tumors (P = 0.046). Conclusions: Given the strong correlation with MMP9, it seems that CD9 might have a role in metastasis in human BC. However, much more studies are required to further support this hypothesis.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"112 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79639353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Malik, Prajjalendra Barooah, Snigdha Saikia, Subhash Medhi, S. Kalita, Manas Jyoti Kalita, P. Das, K. Dutta, Pooja Bharali, M. Sarma, Preeti Sarma, M. Bhattacharyya, P. Kar, B. Goswami, Musaed Alkholief, A. Alshamsan
Background: The microRNA (miRNA) mediated translational repression can cause various diseases in humans. The liver-specific miRNA (microRNA-122 (miR-122)) is primarily involved in tissue tropism during hepatitis C virus (HCV) infection which ultimately leads to hepatocellular carcinoma (HCC). Objectives: This study focuses on evaluating host serum miR-122 as a prognostic marker in HCV-induced hepatocellular carcinoma. Methods: Evaluation of miR-122 expression was carried out by quantitative real time PCR. Results: Positive expression of miR-122 was observed in patients with chronic hepatitis C (CHC) followed by HCC patients compared to healthy controls. A difference in median levels of the miR-122 expression in CHC and HCC patients (P < 0.000) was found in contrast to cirrhosis patients (P = 0.511). The serum miR-122 expression was found threefold higher in liver cirrhosis patients than chronic hepatitis. Further, the area under the receiver operating characteristic curve (AUROC) analysis of miR-122 expression profile can efficiently distinguish CHC patients (AUROC = 0.978, P = 0.000, 95% confidence interval (CI) = 0.958 to 0.998) and HCC from healthy controls (AUROC = 0.971, P = 0.000, 95% CI = 0.944 to 0.997). Moreover, receiver operating characteristic (ROC) curve analysis significantly distinguished between CHC patients from cirrhosis patients (AUROC = 0.955, P = 0.000, 95% CI = 0.925 to 0.986) but not CHC from HCC patients (AUROC = 0.584, P = 0.104, 95% CI = 0.485 to 0.684). This study revealed a substantial correlation of miR-122 with HCV viral load (r = 0.56, P = 0.000), ALT (r = 0.67, P = 0.000) and AST (r = 0.65, P = 0.000) levels. Conclusions: Serum miR-122 can potentially serve as a promising prognostic tool for HCV induced HCC.
背景:miRNA介导的翻译抑制可引起人类多种疾病。肝脏特异性miRNA (microRNA-122 (miR-122))主要参与丙型肝炎病毒(HCV)感染期间的组织趋向性，最终导致肝细胞癌(HCC)。目的:本研究的重点是评估宿主血清miR-122作为hcv诱导的肝细胞癌的预后标志物。方法:采用实时荧光定量PCR法检测miR-122的表达。结果:与健康对照组相比，miR-122在慢性丙型肝炎(CHC)患者和HCC患者中呈阳性表达。与肝硬化患者相比，CHC和HCC患者miR-122的中位表达水平存在差异(P < 0.000) (P = 0.511)。肝硬化患者血清miR-122表达比慢性肝炎患者高3倍。此外，miR-122表达谱的受试者工作特征曲线下面积(AUROC)分析可以有效区分CHC患者(AUROC = 0.978, P = 0.000, 95%可信区间(CI) = 0.958 ~ 0.998)和健康对照组的HCC (AUROC = 0.971, P = 0.000, 95% CI = 0.944 ~ 0.997)。此外，受试者工作特征(ROC)曲线分析在CHC患者与肝硬化患者之间有显著差异(AUROC = 0.955, P = 0.000, 95% CI = 0.925 ~ 0.986)，而HCC患者之间无显著差异(AUROC = 0.584, P = 0.104, 95% CI = 0.485 ~ 0.684)。本研究显示miR-122与HCV病毒载量(r = 0.56, P = 0.000)、ALT (r = 0.67, P = 0.000)和AST (r = 0.65, P = 0.000)水平存在显著相关性。结论:血清miR-122可能作为HCV诱导的HCC的预后工具。
{"title":"Circulating MicroRNA-122 as a Potential Biomarker for Hepatitis C Virus Induced Hepatocellular Carcinoma","authors":"A. Malik, Prajjalendra Barooah, Snigdha Saikia, Subhash Medhi, S. Kalita, Manas Jyoti Kalita, P. Das, K. Dutta, Pooja Bharali, M. Sarma, Preeti Sarma, M. Bhattacharyya, P. Kar, B. Goswami, Musaed Alkholief, A. Alshamsan","doi":"10.5812/ijcm-131221","DOIUrl":"https://doi.org/10.5812/ijcm-131221","url":null,"abstract":"Background: The microRNA (miRNA) mediated translational repression can cause various diseases in humans. The liver-specific miRNA (microRNA-122 (miR-122)) is primarily involved in tissue tropism during hepatitis C virus (HCV) infection which ultimately leads to hepatocellular carcinoma (HCC). Objectives: This study focuses on evaluating host serum miR-122 as a prognostic marker in HCV-induced hepatocellular carcinoma. Methods: Evaluation of miR-122 expression was carried out by quantitative real time PCR. Results: Positive expression of miR-122 was observed in patients with chronic hepatitis C (CHC) followed by HCC patients compared to healthy controls. A difference in median levels of the miR-122 expression in CHC and HCC patients (P < 0.000) was found in contrast to cirrhosis patients (P = 0.511). The serum miR-122 expression was found threefold higher in liver cirrhosis patients than chronic hepatitis. Further, the area under the receiver operating characteristic curve (AUROC) analysis of miR-122 expression profile can efficiently distinguish CHC patients (AUROC = 0.978, P = 0.000, 95% confidence interval (CI) = 0.958 to 0.998) and HCC from healthy controls (AUROC = 0.971, P = 0.000, 95% CI = 0.944 to 0.997). Moreover, receiver operating characteristic (ROC) curve analysis significantly distinguished between CHC patients from cirrhosis patients (AUROC = 0.955, P = 0.000, 95% CI = 0.925 to 0.986) but not CHC from HCC patients (AUROC = 0.584, P = 0.104, 95% CI = 0.485 to 0.684). This study revealed a substantial correlation of miR-122 with HCV viral load (r = 0.56, P = 0.000), ALT (r = 0.67, P = 0.000) and AST (r = 0.65, P = 0.000) levels. Conclusions: Serum miR-122 can potentially serve as a promising prognostic tool for HCV induced HCC.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"19 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76993809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Breast cancer disease is an important public health trouble in the world. Over the past 2 decades, incidences of breast cancer among Iranian women have shown an alarmingly rapid increase. Mammography screening can lead to early detection and management of breast cancer and it also plays an important preventive role in decreasing breast cancer, especially among women over 40 years old. Objectives: This paper aims at reporting the psychometric properties of a questionnaire on mammography behavior based on health action process approach (HAPA) model. Methods: This cross-sectional study was performed between May and September 2017, and was attended by 400 women aged 40 years and older, in comprehensive health service centers in Iran. The research subjects were selected by multi-stage cluster sampling. The instrument was designed basis on the constructs of HAPA and current literature. The scale’s psychometric properties were examined by exploratory factor analysis (EFA), infraclass correlation coefficient (ICC), and Cronbach’s alpha. Results: The results showed 45 items of the questionnaire, 41 items had important item-to-total correlations (P < 0.05), and they were placed in 8 factors that contributed 60.88% of the scale variance. Conclusions: The research findings contribute to the reliability and validity of the HAPA model for predictively evaluating mammography goals.
{"title":"Design and Psychometric Evaluation of Mammography Behavior Predicting Scale (MBPS)","authors":"Fazlollah Ghofranipour, F. Pourhaji","doi":"10.5812/ijcm-123884","DOIUrl":"https://doi.org/10.5812/ijcm-123884","url":null,"abstract":"Background: Breast cancer disease is an important public health trouble in the world. Over the past 2 decades, incidences of breast cancer among Iranian women have shown an alarmingly rapid increase. Mammography screening can lead to early detection and management of breast cancer and it also plays an important preventive role in decreasing breast cancer, especially among women over 40 years old. Objectives: This paper aims at reporting the psychometric properties of a questionnaire on mammography behavior based on health action process approach (HAPA) model. Methods: This cross-sectional study was performed between May and September 2017, and was attended by 400 women aged 40 years and older, in comprehensive health service centers in Iran. The research subjects were selected by multi-stage cluster sampling. The instrument was designed basis on the constructs of HAPA and current literature. The scale’s psychometric properties were examined by exploratory factor analysis (EFA), infraclass correlation coefficient (ICC), and Cronbach’s alpha. Results: The results showed 45 items of the questionnaire, 41 items had important item-to-total correlations (P < 0.05), and they were placed in 8 factors that contributed 60.88% of the scale variance. Conclusions: The research findings contribute to the reliability and validity of the HAPA model for predictively evaluating mammography goals.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"261 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79967805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saiedeh Haji-Maghsoudi, M. Farshchian, M. Sadeghifar, G. Roshanaei, H. Mahjub
Background: Skin cancer, as one of the most common cancers, is partly associated with environmental conditions. Objectives: The main purpose of this study was to investigate the effect of environmental factors on the incidence of skin cancer. Methods: The dataset contains the age-standardized incidence rate (ASR) of skin cancer in all provinces of Iran during a six-year period of time. Also, there were meteorological variables for a 29-year period for the provinces. We used the mean of meteorological variables for the 29-year period for each province as predictors. The ASR of skin cancer in each province in six years was considered as the response variable. Also, gender, latitude, altitude, wind speed, relative humidity, cloudy hours duration, and maximum air temperature in each province were considered independent variables. A mixed effects polynomial regression model was applied to data analysis. Results: Based on the applied model, the trend of ASR of skin cancer in different provinces was statistically significant (P < 0.001). The ASR of skin cancer for males was more than the females (P < 0.001). Furthermore, the positive linear effect of latitude was significant (P = 0.002). However, the quadratic term showed a deceleration in the growth rate of skin cancer incidence with increasing latitude. Furthermore, there was a positive significant impact of altitude on skin cancer incidence (P = 0.045). Conclusions: Health policymakers in their prevention planning should consider geographical conditions as influencing factors on skin cancer incidence. Moreover, men should be given more attention as the main group at risk for this cancer.
{"title":"The Impact of Environmental Factors on Skin Cancer","authors":"Saiedeh Haji-Maghsoudi, M. Farshchian, M. Sadeghifar, G. Roshanaei, H. Mahjub","doi":"10.5812/ijcm-119906","DOIUrl":"https://doi.org/10.5812/ijcm-119906","url":null,"abstract":"Background: Skin cancer, as one of the most common cancers, is partly associated with environmental conditions. Objectives: The main purpose of this study was to investigate the effect of environmental factors on the incidence of skin cancer. Methods: The dataset contains the age-standardized incidence rate (ASR) of skin cancer in all provinces of Iran during a six-year period of time. Also, there were meteorological variables for a 29-year period for the provinces. We used the mean of meteorological variables for the 29-year period for each province as predictors. The ASR of skin cancer in each province in six years was considered as the response variable. Also, gender, latitude, altitude, wind speed, relative humidity, cloudy hours duration, and maximum air temperature in each province were considered independent variables. A mixed effects polynomial regression model was applied to data analysis. Results: Based on the applied model, the trend of ASR of skin cancer in different provinces was statistically significant (P < 0.001). The ASR of skin cancer for males was more than the females (P < 0.001). Furthermore, the positive linear effect of latitude was significant (P = 0.002). However, the quadratic term showed a deceleration in the growth rate of skin cancer incidence with increasing latitude. Furthermore, there was a positive significant impact of altitude on skin cancer incidence (P = 0.045). Conclusions: Health policymakers in their prevention planning should consider geographical conditions as influencing factors on skin cancer incidence. Moreover, men should be given more attention as the main group at risk for this cancer.","PeriodicalId":44764,"journal":{"name":"International Journal of Cancer Management","volume":"48 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88413933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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