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Evolvability of cancer-associated genes under APOBEC3A/B selection. 癌症相关基因在 APOBEC3A/B 选择下的进化性。
4区 经济学 Q3 ECONOMICS Pub Date : 2023-12-05 DOI: 10.1101/2023.08.27.554991
Joon-Hyun Song, Liliana M Dávalos, Thomas MacCarthy, Mehdi Damaghi

Evolvability is an emergent hallmark of cancer that depends on intra-tumor heterogeneity and, ultimately, genetic variation. Mutations generated by APOBEC3 cytidine deaminases can contribute to genetic variation and the consequences of APOBEC activation differ depending on the stage of cancer, with the most significant impact observed during the early stages. However, how APOBEC activity shapes evolutionary patterns of genes in the host genome and differential impacts on cancer-associated and non-cancer genes remain unclear. Analyzing over 40,000 human protein-coding transcripts, we identified distinct distribution patterns of APOBEC3A/B TC motifs between cancer-related genes and controls, suggesting unique associations with cancer. Studying a bat species with many more APOBEC3 genes, we found diverse motif patterns in orthologs of cancer genes compared to controls, similar to humans and suggesting APOBEC evolution to reduce impacts on the genome rather than the converse. Simulations confirmed that APOBEC-induced heterogeneity enhances cancer evolution, shaping clonal dynamics through bimodal introduction of mutations in certain classes of genes. Our results suggest that a major consequence of the bimodal distribution of APOBEC affects greater cancer heterogeneity.

可进化性是癌症的一个新特征,它取决于肿瘤内部的异质性,并最终取决于遗传变异。APOBEC3 胞苷脱氨酶产生的突变可导致基因变异,APOBEC 激活的后果因癌症的不同阶段而异,早期阶段的影响最为显著。然而,APOBEC的活性如何影响宿主基因组中基因的进化模式以及对癌症相关基因和非癌症基因的不同影响仍不清楚。通过分析 40,000 多条人类蛋白质编码转录本,我们发现了癌症相关基因和对照基因之间 APOBEC3A/B TC motifs 的不同分布模式,这表明它们与癌症有着独特的联系。在研究一种拥有更多 APOBEC3 基因的蝙蝠物种时,我们发现与对照组相比,癌症基因的直向同源物中存在着不同的主题模式,这与人类类似,表明 APOBEC 的进化是为了减少对基因组的影响,而不是相反。模拟证实,APOBEC诱导的异质性增强了癌症进化,通过在某些基因类别中引入双峰突变来塑造克隆动态。我们的研究结果表明,APOBEC双峰分布的一个主要后果是影响了癌症的异质性:通过衡量基因受 APOBEC 活性影响的程度,我们发现许多基因在人类基因组中具有最大的稳健性。有趣的是,拥有许多 APOBEC 基因的蝙蝠基因组中的分布情况也类似。相反,在分析癌症相关基因子集时,其分布呈双峰型,许多基因似乎易受APOBEC活性的影响。对人类基因和其他物种基因的直向同源物的分析表明,APOBEC对具有相同功能的基因的影响程度差异很大。
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引用次数: 0
Structural change, labor market and employment in brazil after the 2017 labor market reform 2017年巴西劳动力市场改革后的结构性变化、劳动力市场与就业
IF 1 4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan2304627a
E. Araujo, Rinaldo Galete, C. Caldarelli
The objective of this study is to analyze the effects of the set of measures adopted by the labor reform of 2017 on the generation of employment and income in Brazil. The study is based on the literature that highlights the importance of structural change in employment as a key element for economic growth and development, emphasizing that in Brazil, there is still a view that the labor market should take on more flexible work relationships to advance in the improvement of jobs, levels of employment, productivity and income. Subsequently, the article summarizes and critically comments on the main measures of the labor law reforms adopted in post-2017 Brazil. Finally, it presents an analysis of the behavior of the labor market in Brazil between 2012 and 2022 based on data from the PNADC/IBGE survey. The main results of the survey confirm that the labor reform of 2017 has not shown advances in labor market indicators or in the main macroeconomic aggregates of the country. In contrast, the data suggest deterioration in the indicators of employment, income and allocation of workers in occupations with low productivity and income characteristics.
本研究的目的是分析2017年巴西劳动改革采取的一系列措施对创造就业和收入的影响。该研究基于强调就业结构变化作为经济增长和发展关键因素的重要性的文献,强调在巴西,仍然有一种观点认为,劳动力市场应该采取更灵活的工作关系,以促进就业、就业水平、生产力和收入的改善。随后,文章对2017年后巴西劳动法改革的主要措施进行了总结和批判性评论。最后,根据PNADC/IBGE调查的数据,对2012年至2022年巴西劳动力市场的行为进行了分析。调查的主要结果证实,2017年的劳动改革并没有显示出劳动力市场指标或该国主要宏观经济总量的进步。相反,数据表明,在生产率和收入特征较低的职业中,工人的就业、收入和分配指标出现恶化。
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引用次数: 0
An emprical study to investigate the size of non-governmental organizations in OECD countries 一项调查经合组织国家非政府组织规模的实证研究
IF 1 4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan211130011t
A. Tosun, A. Yilmaz
This study aimed to analyze the factors affecting the size of non-governmental organizations (NGOs) from a multinational perspective. Empirical analyses were conducted through econometric modeling, and the data of the 17 countries from 2003 to 2019 were used. The data was obtained from the World Bank and OECD database. We used advanced panel data estimation techniques (CUP-FM and CUP-BC) to obtain long-run coefficients. GDP per Capita, general government final consumption expenditure, adult education at tertiary level, and Gini index growth declined grants by private agencies and NGOs? contribution to GDP (GinGDP) initially but after a threshold level, GinGDP increased with growth at later stages of these variables. Urban population growth, employment, and foreign population have reducing effect on the size of NGOs. The size of NGOs has bidirectional causality relationship between GDP per capita, adult population at tertiary education level, employment to population ratio, and Gini index; and unidirectional causality between urban population growth, general government final consumption expenditure, and foreign population.
本研究旨在从跨国视角分析影响非政府组织规模的因素。采用计量经济模型对17个国家2003 - 2019年的数据进行实证分析。这些数据来自世界银行和经合发组织的数据库。我们使用了先进的面板数据估计技术(CUP-FM和CUP-BC)来获得长期系数。人均GDP、政府一般最终消费支出、成人高等教育水平和基尼指数增长下降了私人机构和非政府组织的拨款?但在阈值水平之后,在这些变量的后期阶段,GinGDP随着增长而增加。城市人口增长、就业、外来人口对ngo规模的影响是递减的。非政府组织规模与人均GDP、高等教育成人人口、就业人口比、基尼系数之间存在双向因果关系;城市人口增长、政府一般最终消费支出与外来人口之间存在单向因果关系。
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引用次数: 0
Labour market reforms in brazil (2017-2021): An analysis of the effects of recent flexibilization on labor market legislation 巴西劳动力市场改革(2017-2021):近期劳动力市场立法灵活性影响分析
IF 1 4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan2304601o
J. Oreiro, L. Gabriel, Stefan D’Amato, Kalinka da Silva
The main objective of this work is to analyze the effects of Brazilian Labor Market Reform (BLMR) in the short run and, based on identified changes in the economy in recent decades, to verify how these changes have affected the labor market. Four methods were used in a complementary way: (i) employment quality index; (ii) panel data estimation method; (iii) synthetic control method and (iv) microdata analysis. We observed that there was no considerable increase in the quality of employment and formal employment and the rate of unemployment did not decrease after the implementation of these changes. Part of this dynamic is cyclical and related to exogenous shocks, such as the COVID pandemic on the Brazilian economy. Finally, according to econometric analysis, the rate of unemployment in Brazil is more responsive to investment rates and the business environment than to unit labor cost and changes in labor legislation.
这项工作的主要目的是分析巴西劳动力市场改革(BLMR)在短期内的影响,并根据近几十年来经济中确定的变化,验证这些变化如何影响劳动力市场。四种方法互补使用:(i)就业质量指数;(ii)面板数据估计法;(三)综合控制方法和(四)微观数据分析。我们注意到,在实施这些改革后,就业和正式就业的质量并没有显著提高,失业率也没有下降。这种动态部分是周期性的,与外部冲击有关,例如新冠疫情对巴西经济的影响。最后,根据计量经济学分析,巴西的失业率对投资率和商业环境的反应比对单位劳动力成本和劳动立法的变化更敏感。
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引用次数: 1
The impacts of the Brazilian Labour Reform on employment, output, and labour productivity 巴西劳动改革对就业、产出和劳动生产率的影响
IF 1 4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan2304647a
C. Amitrano, Alanna de Oliveira, Gabriel Squeff
This paper discusses the role played by the recent Brazilian Labour Reform (BLR) in conditioning the level and the rate of growth of employment, value added and productivity in the Brazilian economy from 2017. Our main findings are that after BLR, the share of informal employment, value added and productivity increased, as well as those shares in low productivity sectors. Furthermore, we show that the employment created in low-productivity sectors (formal and informal) were moved to high-productivity sectors in the years after the implementation of the 2017 labour reform, the aggregate levels of value added and productivity would have been much higher than otherwise.
本文讨论了最近巴西劳工改革(BLR)在调节2017年巴西经济中就业、增加值和生产率的水平和增长率方面所起的作用。我们的主要发现是,在BLR之后,非正规就业、增加值和生产率的份额增加了,低生产率部门的份额也增加了。此外,我们表明,在实施2017年劳动改革后的几年里,低生产率部门(正式和非正式)创造的就业转移到了高生产率部门,增加价值和生产率的总水平将大大高于其他部门。
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引用次数: 0
Sectoral distribution of FDI and employment: Evidence from post- transitional European countries 外国直接投资和就业的部门分布:来自转型后欧洲国家的证据
IF 1 4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan2304573j
Kosta Josifidis, Novica Supic
This paper examines, from the perspective of Post-Keynesian economics, the effects of Foreign Direct Investment (FDI) on the employment rate in 18 post-transitional European countries from 1995 to 2021. Using a two-step system Generalised Method of Moments (GMM) panel data estimator, we test the hypothesis that the employment impact of investment depends on the interaction of FDI and domestic investment in terms of crowding-in and crowding-out relationships, assuming that this relationship is sensitive to the sectoral distribution of FDI stock. Our findings suggest that the reallocation of FDI inflows from the manufacturing sector to the less labour intensive financial and information and communication technology (ICT) sectors tends to reduce the employment effect of FDI both directly and indirectly by reducing the magnitude of the crowding- in effect of FDI on domestic investment. The outcome of our study is of great interest to economic policy makers. If foreign investment displaces domestic investment and reduces employment in high value-added sectors, policies intended to attract foreign capital could be challenged and undermined. Otherwise, if foreign and domestic investment in sectors with high added value are complementary, it justifies policies aimed at attracting foreign investment.
本文从后凯恩斯经济学的角度考察了1995年至2021年18个转型后欧洲国家的外国直接投资(FDI)对就业率的影响。使用两步系统广义矩量法(GMM)面板数据估计器,我们检验了投资对就业的影响取决于FDI和国内投资在挤进和挤出关系方面的相互作用的假设,假设这种关系对FDI存量的行业分布很敏感。我们的研究结果表明,FDI流入从制造业向劳动密集型程度较低的金融和信息通信技术(ICT)行业的再配置,往往会通过降低FDI对国内投资的拥挤效应的程度,直接或间接地降低FDI的就业效应。我们的研究结果引起了经济政策制定者的极大兴趣。如果外国投资取代国内投资并减少高附加值部门的就业,旨在吸引外国资本的政策就可能受到挑战和破坏。否则,如果在高附加值部门的外国和国内投资是互补的,就有理由采取旨在吸引外国投资的政策。
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引用次数: 0
Contingent claims analysis as a credit risk metric: Evidence from Turkey 或有债权分析作为信用风险度量:来自土耳其的证据
4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan220516019c
Şaban Çelik, Burcu Baskurt
Credit ratings have become open to dispute in recent years regarding their objectivity, timeliness, and the criteria considered in the assignment process, which resulted in an inclination toward other methods to measure credit risk. This study applies contingent claims analysis, a novel risk analysis technique, in Turkey to assess their credit risk appropriately and investigate the determinants of the sovereign credit risk correctly. While the technique has been applied in Turkey before, the study contributes to the results of the preceding literature by applying the technique at a wider spectrum in terms of regarding the assessed risk indicators, time horizon considered, diagnosis tests, and sensitivity analyses. Risk indicators are calculated by applying this method to Turkey between July 2009 and December 2020. Results highlight that the movements in the risk indicators reflect the market. To ensure robustness, the Spearman rank-order correlations of the model risk measures with three market indicators are calculated, and sensitivity analyses are done. The credit default swaps are found to be correlated with all of the model risk measures, while the distance to distress is correlated with sovereign bond spreads, affirming model robustness. Analysis results highlight that among the variables for which sensitivities are assessed, changes occurring in the volatility of local currency liabilities heavily impact the risk indicators. Hence, the contingent claims approach model is robust in considering the correlations of model risk indicators with actual market data. Therefore, the model can be used in policymaking for realistic results.
近年来,信用评级在客观性、及时性和分配过程中考虑的标准方面受到争议,这导致人们倾向于采用其他方法来衡量信用风险。本研究应用或有债权分析,一种新颖的风险分析技术,在土耳其适当地评估他们的信用风险,并正确地调查主权信用风险的决定因素。虽然该技术以前曾在土耳其应用过,但本研究在评估的风险指标、考虑的时间范围、诊断测试和敏感性分析方面更广泛地应用了该技术,从而有助于上述文献的结果。将该方法应用于2009年7月至2020年12月期间的土耳其,计算出风险指标。结果表明,风险指标的变动反映了市场。为保证稳健性,计算模型风险测度与三个市场指标的Spearman秩序相关性,并进行敏感性分析。发现信用违约掉期与所有模型风险指标相关,而与危机的距离与主权债券利差相关,证实了模型的稳健性。分析结果突出表明,在评估敏感性的变量中,本币负债波动率的变化严重影响风险指标。因此,或有债权方法模型在考虑模型风险指标与实际市场数据的相关性时是稳健的。因此,该模型可用于政策制定,结果切合实际。
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引用次数: 0
The short- and long-run relationship between house prices and bank credit in developed and emerging market economies: A comparative study 发达经济体和新兴市场经济体房价与银行信贷的短期和长期关系:比较研究
IF 1 4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan181004012d
T. Dawood
This study compares the short- and long-term relationships between house prices and bank credit in developed and Emerging Market Economies. This fact is an essential issue because most financing is facilitated by bank credit. Using quarterly data from 22 developed and six Emerging Market Economies and the panel autoregressive distributed lag model method, this study found that real house prices are the prominent factor of bank credit. Moreover, the magnitude of house prices and gross domestic product relationship with domestic bank credit is considerably greater in Emerging Market Economies than in developed nations. Meanwhile, the foreign interest rate on bank credit is nearly four times greater in Emerging Market Economies. Further, the exchange rate-credit relationship is positive for developed countries, whereas negative for Emerging Market Economies. Therefore, authorities maintaining financial stability must pay close attention to real house price dynamics. Moreover, Emerging Market Economies must also consider the exchange rate and foreign interest rates in managing credit growth.
本研究比较了发达经济体和新兴市场经济体的房价与银行信贷之间的短期和长期关系。这一事实至关重要,因为大多数融资都是由银行信贷促成的。本文利用22个发达经济体和6个新兴市场经济体的季度数据,运用面板自回归分布滞后模型方法,发现实际房价是影响银行信贷的突出因素。此外,与发达国家相比,新兴市场经济体的房价和国内生产总值(gdp)与国内银行信贷的关系要大得多。与此同时,新兴市场经济体的外国银行信贷利率几乎是中国的四倍。此外,汇率-信贷关系对发达国家是积极的,而对新兴市场经济体是消极的。因此,维护金融稳定的当局必须密切关注实际房价动态。此外,新兴市场经济体在管理信贷增长时还必须考虑汇率和外国利率。
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引用次数: 0
A proper developmental state framework for Greece 为希腊建立一个适当的发展性国家框架
IF 1 4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan220511002a
P. Arestis, N. Karagiannis
Post World War II, Greece was enjoying, by and large, significant economic growth that was only slightly lower than that of other Western European nations. However, immediately after the financial crisis of 2007-08, the country faced a sovereign debt crisis. This continuing multifaceted crisis reached the populace as a series of restrictive measures and sudden reforms (what Galbraith, 2016, labels ?economic policy as moral abomination?), which resulted in a very long recession, high unemployment, massive inequalities and marginalization, increased social exclusion, and huge migration of thousands of well-educated Greeks. Within such economic development context, this contribution provides an overview of Greece?s past economic development efforts and challenges (Section 2); discusses important notions of a highly interventionist developmental state framework with ?Greek characteristics? as its main focus (Section 3); and offers developmental state-based policy implications, which are deemed necessary for the revival and global repositioning of Greek industrial sectors of high potential and achievability (Section 4). Summary and conclusions end the article.
第二次世界大战后,希腊总体上享有显著的经济增长,仅略低于其他西欧国家。然而,在2007-08年金融危机之后,该国立即面临主权债务危机。这场持续的多方面危机以一系列限制措施和突然改革(加尔布雷斯,2016年,将经济政策称为道德可憎?)的形式影响到了民众,导致了长期的经济衰退、高失业率、大规模的不平等和边缘化、社会排斥加剧,以及成千上万受过良好教育的希腊人大规模移民。在这样的经济发展背景下,这篇文章提供了希腊?中国过去的经济发展努力和挑战(第2部分);讨论了具有希腊特色的高度干预主义发展国家框架的重要概念。作为其主要焦点(第3节);并提供了基于国家的发展政策含义,这被认为是希腊高潜力和可实现性工业部门的复兴和全球重新定位所必需的(第4节)。摘要和结论在文章的最后。
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引用次数: 0
The asymmetric effects of third-country exchange rate volatility on Turkish-German commodity trade 第三国汇率波动对土德商品贸易的不对称影响
IF 1 4区 经济学 Q3 ECONOMICS Pub Date : 2023-01-01 DOI: 10.2298/pan220624015k
Waqar Khalid, Irfan Civcir, Hüseyin Özdeşer
This study examines the asymmetric effects of third-country exchange rate volatility on Turkish-German commodity trade. We analyzed annual time-series data spanning 1980-2022 for 79 (93) Turkish export (import) industries. The ARDL model found that third-country volatility, using the lira-dollar, had a significant short-term symmetric effect on 59 (67) Turkish export (import) industries. The NARDL model found that third-country volatility had a short-run asymmetric effect on trade volumes in more than half of the Turkish export and import industries. However, the short-run asymmetric effects turned into long-run asymmetric effects in about 50 percent of the industries. The results establish that nonlinear models lead to more significant short-run and long-run effects. The empirical evidence shows that the asymmetric assumption alone is insufficient, and third-country volatility should also be considered. The results suggest that all traders should consider how policy changes in a third-country may affect cross-country trade when designing their trade policies in a diversified trade environment.
本研究考察了第三国汇率波动对土耳其-德国商品贸易的不对称影响。我们分析了1980-2022年间79(93)个土耳其出口(进口)行业的年度时间序列数据。ARDL模型发现,使用里拉美元计算的第三国波动对土耳其59(67)个出口(进口)行业具有显著的短期对称效应。NARDL模型发现,第三国的波动对土耳其一半以上的进出口行业的贸易量有短期的不对称影响。然而,在大约50%的行业中,短期不对称效应转化为长期不对称效应。结果表明,非线性模型对短期和长期的影响更为显著。经验证据表明,仅采用不对称假设是不够的,还应考虑第三国波动。研究结果表明,所有贸易商在设计多元化贸易环境下的贸易政策时,都应考虑第三国的政策变化对跨国贸易的影响。
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引用次数: 1
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Panoeconomicus
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