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Workshop (Clinical/Best Practice Implementation) ID 2000428 讲习班(临床/最佳做法实施) ID 2000428
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-2000428s
Julio C Furlan, M. G. Fehlings, James Milligan, Sukhvinder Kalsi-Ryan
This workshop aims to overview degenerative cervical myelopathy (DCM), which is the most common cause of non-traumatic spinal cord injury across the world. DCM is estimated to affect approximately 1 in 50 adults; however, < 10% receive a diagnosis, and lifelong disability remains a common outcome. Upon completion of this workshop, attendees will (1) understand the diagnostic criteria and investigations for DCM and avoid misdiagnosis in the primary care level; (2) recognise the indications and role of surgical treatment; (3) comprehend the impact of prehabilitation and rehabilitation; (4) understand the alternatives for non-operative management of DCM; and (5) appreciate the importance of raising awareness of this disease. This workshop will review the diagnostic criteria and investigations for individuals with different degrees of DCM, the current clinical practice guidelines for management of DCM with focus on the role of surgical decompression of spinal cord, the role of prehabilitation and rehabilitation, current non-operative options for patients with DCM, and some initiatives focused on raising awareness of this disease. This workshop will include lectures (10-15 minutes each) with illustrative cases followed by open discussion on the following topics: (i) diagnosis, misdiagnosis and investigations in DCM; (ii) surgical management of DCM; (iii) prehabilitation and rehabilitation in DCM; and (iv) non-operative management of DCM. Although DCM is the most common cause of non-traumatic spinal cord disease, there is a need for the development of a tailored and multi-disciplinary care framework for management of DCM, which would improve patients’ outcomes. Greater awareness of DCM among healthcare professionals is urged to avoid misdiagnosis and mitigate the long-term consequences of this disease.
本研讨会旨在概述退行性颈椎脊髓病(DCM),这是全球最常见的非外伤性脊髓损伤原因。据估计,大约每 50 个成年人中就有 1 人患有 DCM;然而,只有不到 10% 的人得到诊断,终生残疾仍然是常见的结果。完成本讲座后,与会者将:(1)了解 DCM 的诊断标准和检查方法,避免在初级保健阶段出现误诊;(2)认识手术治疗的适应症和作用;(3)理解预康复和康复的影响;(4)了解 DCM 非手术治疗的替代方法;以及(5)了解提高对该疾病认识的重要性。 本次研讨会将回顾不同程度 DCM 患者的诊断标准和检查方法、目前治疗 DCM 的临床实践指南(重点是脊髓手术减压的作用)、术前康复和康复治疗的作用、目前 DCM 患者的非手术治疗方案,以及一些旨在提高人们对该疾病认识的举措。 研讨会将包括讲座(每场 10-15 分钟)和病例说明,然后就以下主题进行公开讨论:(i) DCM 的诊断、误诊和检查;(ii) DCM 的手术治疗;(iii) DCM 的术前康复和康复治疗;以及 (iv) DCM 的非手术治疗。 虽然 DCM 是非外伤性脊髓疾病最常见的病因,但仍有必要为管理 DCM 制定一个量身定制的多学科护理框架,以改善患者的预后。我们敦促医疗保健专业人员提高对 DCM 的认识,以避免误诊并减轻该疾病的长期后果。
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引用次数: 0
Poster (Knowledge Generation) ID 1969160 海报(知识生成)ID 1969160
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-1969160s
Julio C Furlan, E. Loh, M. Boulos
This ongoing cross-sectional study aims to examine the potential association between moderate-to-severe sleep apnea and severe cardiovascular dysfunction after spinal cord injury (SCI). This cross-sectional study included participants who were newly diagnosed with sleep apnea using a home-based/hospital unattended sleep screening test that quantifies the apnea-hypopnea index (AHI). Episodes of AD were defined as a sudden increase in systolic blood pressure (BP) of at least 20 mmHg. We exclude episodes of AD during sleep that were caused by triggers other than apnea or hypopnea. This study included English-speaking adults with subacute or chronic (≥1 month after SCI onset), cervical or high-thoracic (T6 or more cranial), complete or incomplete SCI, who reported clinical symptoms and/or signs suggestive of sleep apnea. This study included 45 individuals (14 females and 31 males; age range: 20 to 84 years, mean age: 57.0 years) with motor complete (n=22) or incomplete SCI at cervical (n=38) or high thoracic levels. Time since SCI varied from 1.5 months to 52 years. Their mean apnea-hypopnea index (AHI) was 16.0 events/hour (AHI range: 0.8 to 51.7 events/hour). Higher AHI was significantly correlated with more frequent silent episodes of AD (Rsqr=0.220, p=0.001) during sleep. The AHI was not associated with systolic BP (p=0.903), diastolic BP (p=0.639), mean arterial pressure (p=0.714), and heart rate (p=0.669) during sleep. The results of this cross-sectional study suggest that more severe sleep apnea is associated with frequent silent episodes of AD during sleep among individuals living with cervical or high-thoracic SCI.
这项正在进行的横断面研究旨在探讨中重度睡眠呼吸暂停与脊髓损伤(SCI)后严重心血管功能障碍之间的潜在关联。 这项横断面研究纳入了通过家庭/医院无人值守睡眠筛查测试新诊断出患有睡眠呼吸暂停的参与者,该测试可量化呼吸暂停-低通气指数(AHI)。AD发作的定义是收缩压(BP)突然升高至少20毫米汞柱。我们排除了睡眠中因呼吸暂停或低通气以外的诱因引起的急性呼吸暂停发作。 本研究纳入了亚急性或慢性(SCI 发病后≥1 个月)、颈椎或高胸椎(T6 或以上颅骨)、完全或不完全 SCI 的英语成年人,他们报告了提示睡眠呼吸暂停的临床症状和/或体征。 本研究共纳入 45 名患者(14 名女性和 31 名男性;年龄范围:20 至 84 岁,平均年龄:57.0 岁),他们均患有颈椎(38 名)或胸椎高位运动性完全(22 名)或不完全 SCI。SCI 后的时间从 1.5 个月到 52 年不等。他们的平均呼吸暂停-低通气指数(AHI)为 16.0 次/小时(AHI 范围:0.8 至 51.7 次/小时)。较高的 AHI 与睡眠中更频繁的无声 AD 发作有明显相关性(Rsqr=0.220,p=0.001)。AHI 与睡眠期间的收缩压(P=0.903)、舒张压(P=0.639)、平均动脉压(P=0.714)和心率(P=0.669)均无关联。 这项横断面研究的结果表明,在患有颈椎或高胸椎 SCI 的患者中,更严重的睡眠呼吸暂停与睡眠中频繁的无声 AD 发作有关。
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引用次数: 0
Student Competition (Knowledge Generation) ID 1985014 学生竞赛(知识生成) ID 1985014
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-1985014s
Lauren Cadel, S. L. Hitzig, Lisa M McCarthy, Shoshana Hahn-Goldberg, Tanya L Packer, Chester H Ho, Aisha K Lofters, Tejal Patel, Stephanie R. Cimino, S. Guilcher
Adults with spinal cord injury/dysfunction (SCI/D) are commonly prescribed multiple medications to manage secondary complications. Significant challenges managing medications have been highlighted, with the need for more support with medication self-management. The objective of this study is to co-develop a toolkit to assist with medication self-management for persons with SCI/D. Adults with SCI/D, caregivers, and healthcare providers will participate in the three steps of concept mapping – brainstorming, sorting and rating, and mapping to identify key components of the toolkit. Participants will generate statements about what should be incorporated into a toolkit to help persons with SCI/D manage their medications. Participants will rate the final list of statements on importance and feasibility and sort the statements into thematic piles. A visual map will be developed by a subset of participants, representing the thematic piles. To date, participants have generated over 500 statements. Ideas generated around the content of the toolkit focus on information about: pharmacological and non-pharmacological options for managing secondary complications, side effects, communicating with providers, and medication access. Ideas specific to the delivery of the toolkit focus on: ensuring an individualized approach, accessibility, and the use of visuals. Statements will be synthesized for sorting and rating and mapping. Subsequent phases of this research will refine the toolkit through interviews and input from our working group. A mixed methods pilot evaluation will then be conducted to assess the feasibility, acceptability, and appropriateness of the toolkit, as well medication knowledge, self-efficacy, and quality of life.
患有脊髓损伤/功能障碍(SCI/D)的成年人通常需要服用多种药物来控制继发性并发症。药物管理方面的巨大挑战已经凸显出来,需要在药物自我管理方面提供更多支持。 本研究旨在共同开发一个工具包,以协助 SCI/D 患者进行药物自我管理。 患有 SCI/D的成年人、护理人员和医疗保健提供者将参与概念绘图的三个步骤--头脑风暴、分类和评级以及绘图,以确定工具包的关键组成部分。参与者将就工具包中应包含哪些内容以帮助 SCI/D 患者管理药物生成陈述。参与者将根据重要性和可行性对最终的陈述清单进行评分,并将陈述按主题分类。一部分参与者将绘制一张可视化地图,代表各组主题。 迄今为止,参与者已经提出了 500 多条陈述。围绕工具包内容产生的想法主要涉及以下方面的信息:控制继发性并发症的药物和非药物选择、副作用、与医疗服务提供者沟通以及药物获取。关于工具包提供方式的具体想法主要集中在:确保个性化方法、可及性和视觉效果的使用。将对陈述进行综合,以便分类、评级和制图。 本研究的后续阶段将通过访谈和工作组的意见来完善工具包。然后将进行混合方法试点评估,以评估工具包的可行性、可接受性和适宜性,以及药物知识、自我效能和生活质量。
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引用次数: 0
Student Competition (Knowledge Generation) ID 1985185 学生竞赛(知识生成) ID 1985185
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-1985185s
Sisuri G. Hemakumara, Zahra Karamzadeh, Darren J. Mann, Trevor S. Barss, Vivian K. Mushahwar
Transcutaneous spinal cord stimulation (tSCS) facilitates spinal networks involving motor function. The purpose of this study is to compare the effect of stimulators used and amplitude of tSCS, applied at the cervical region of the spinal cord, on propriospinal modulation of lower limbs. Corticospinal and spinal reflex excitability were assessed with lower limb motor evoked potentials (MEPs), and Hoffman (H-) reflexes, respectively. Neurologically intact participants (n=6) were recruited. Two stimulators (NeoStim-5 and DS8R) were used, and different tSCS amplitudes at threshold (thresh) and maximum tolerance (max) were applied. The effect of tSCS on the amplitude of the H-reflex evoked in the soleus muscle was assessed, as well as the effect of cervical tSCS on MEPs evoked in the tibialis anterior muscle. Participants completed five conditions including: 1) Control (no stimulation) 2) DS8R Thresh 3) DS8R Max 4) NeoStim-5 Thresh 5) NeoStim-5 Max. At the same tSCS amplitude, the participants subjectively tolerated the NeoStim-5 better than the DS8R. The maximum tolerated amplitude for NeoStim-5 was higher than that of the DS8R, for all participants. Preliminary analysis suggests changes in tSCS amplitude delivered, do not appear to have an effect on the H-reflex and MEP in this small sample of participants. Preliminary findings indicate that different stimulators produce different sensations at the same tSCS amplitudes. Changes in stimulator amplitudes do not appear to have an effect on the electrophysiological outcome on propriospinal modulation. This study sets the basis for understanding mechanisms of tSCS, including cutaneous activation.
经皮脊髓刺激(tSCS)可促进涉及运动功能的脊髓网络。本研究的目的是比较应用于脊髓颈部的经皮脊髓刺激(tSCS)所使用的刺激器和振幅对下肢本体脊髓调制的影响。皮质脊髓和脊髓反射兴奋性分别通过下肢运动诱发电位(MEPs)和霍夫曼(H-)反射进行评估。 招募了神经系统完好的参与者(6 人)。他们使用了两种刺激器(NeoStim-5 和 DS8R),并在阈值(thresh)和最大耐受量(max)时使用了不同的 tSCS 振幅。评估了 tSCS 对诱发比目鱼肌 H 反射振幅的影响,以及颈部 tSCS 对诱发胫骨前肌 MEPs 的影响。参与者完成了五个条件,包括1) 对照组(无刺激) 2) DS8R Thresh 3) DS8R Max 4) NeoStim-5 Thresh 5) NeoStim-5 Max。 在相同的 tSCS 振幅下,参与者对 NeoStim-5 的主观耐受性要好于 DS8R。所有参与者对 NeoStim-5 的最大耐受振幅都高于 DS8R。初步分析表明,在这一小部分参与者中,tSCS 振幅的变化似乎不会对 H 反射和 MEP 产生影响。 初步研究结果表明,在相同的 tSCS 振幅下,不同的刺激器会产生不同的感觉。刺激器振幅的变化似乎不会对本体脊髓调制的电生理结果产生影响。这项研究为了解 tSCS 的机制(包括皮肤激活)奠定了基础。
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引用次数: 0
Student Competition (Knowledge Generation) ID 1987946 学生竞赛(知识生成) ID 1987946
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-1987946s
N. Punjani, Sighild Lemarchant, Svetlana Altamentova, J. Chio, Jian Wang, Yann Godfrin, M. G. Fehlings
NX210c is a 12-amino acid peptide derived from conserved thrombospondin type 1 repeat sequences in the subcommissural organ-spondin, which has a unique multifunctional mechanism of action to ameliorate outcomes following neurological injuries. The aim of this study was to evaluate the efficacy of NX210c to promote functional recovery and tissue repair in a cervical traumatic spinal cord injury (SCI) model. Adult female Wistar rats were subjected to a C6/C7 clip compression-contusion injury and treated once daily with intraperitoneal injections of NX210c (8 mg/kg) or its vehicle for 8 weeks, beginning 4 hours (h) or 8h post-injury (n=16-17/group), with concurrent neurobehavioural tests. Earlier NX210c administration at 4h increased forelimb grip strength (p<0.05) and improved several static and dynamic aspects of locomotion including regularity index and base of support of the forelimbs (CatWalk) (p<0.05). Delaying initial administration of NX210c to 8h, promoted weight gain, accelerated bladder control recovery from 14 to 9 days post-injury, and improved trunk balance (inclined plane) as early as one-week post-injury (p<0.05). 94% of NX210c-treated rats compared to 75% of vehicle controls observed weight support at the delayed initial injection timepoint. Histology (n=6/group) demonstrated greater white matter preservation and reduced cavity size at the injury epicenter, and higher neuronal soma counts caudally, with NX210c starting 8h post-injury compared to the vehicle (p<0.05). NX210c targets various aspects of SCI, improving motor function, bladder control, white matter preservation, and neuronal counts, with more benefits observed at the later initial injection timepoint.
NX210c 是一种 12 氨基酸肽,来源于脊髓膜下器官-spondin 中保守的 thrombospondin 1 型重复序列,具有独特的多功能作用机制,可改善神经损伤后的预后。本研究旨在评估 NX210c 在颈椎创伤性脊髓损伤(SCI)模型中促进功能恢复和组织修复的功效。 成年雌性Wistar大鼠受到C6/C7夹片压迫-灌注损伤,从损伤后4小时或8小时开始,每天腹腔注射一次NX210c(8毫克/千克)或其载体,连续治疗8周(16-17只/组),同时进行神经行为测试。 较早在4小时给药NX210c可增加前肢握力(p<0.05),并改善运动的多个静态和动态方面,包括规律性指数和前肢支撑基础(CatWalk)(p<0.05)。将 NX210c 的首次给药时间延迟至 8 小时可促进体重增加,加快膀胱控制能力在伤后 14 到 9 天的恢复,并在伤后一周内改善躯干平衡(倾斜面)(p<0.05)。与 75% 的药物对照组相比,94% 的 NX210c 治疗大鼠在初始注射延迟时间点观察到体重支持。组织学研究(n=6/组)显示,与对照组相比,NX210c 在损伤后 8 小时开始治疗时,损伤中心的白质保存更完好,空腔缩小,尾部神经元体细胞数增加(p<0.05)。 NX210c针对SCI的各个方面,可改善运动功能、膀胱控制、白质保存和神经元数量,在较晚的初始注射时间点可观察到更多益处。
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引用次数: 0
Workshop (Clinical/Best Practice Implementation) ID 2002364 讲习班(临床/最佳实践实施) ID 2002364
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-2002364s
Kristine Cowley, Peter Athanasopoulos, Chester Ho, Jacquie D. Ripat, Hope Jervis Rademeyer, Peter Warkentin, John Gregory
Spinal cord injury (SCI) affects every aspect of a person’s bodily functions. As such, for a person to survive and strive in the community after SCI, both a comprehensive and effective rehabilitation program, as well as life-sustaining healthcare (i.e., SCI-specific medical services, equipment, and supplies) is needed. Although Canada has a publicly funded universal healthcare system, provinces have flexibility in determining how rehabilitation is delivered and in defining ‘essential’ healthcare. This workshop will consist of two lectures on current standards of care in acute SCI rehabilitation and provision of life-sustaining SCI healthcare services, equipment, and supplies in Canada, followed by an initial overview of standards in other comparable countries and discussion of next steps for developing equity and consistency in Canada for SCI rehabilitation and provision of SCI-related healthcare needs. Upon completion of this workshop, attendees will understand:
脊髓损伤(SCI)会影响患者身体机能的方方面面。因此,一个人在脊髓损伤后要想在社区中生存和发展,就需要全面有效的康复计划以及维持生命的医疗保健(即脊髓损伤专用医疗服务、设备和用品)。虽然加拿大有一个由政府资助的全民医疗保健系统,但各省在决定如何提供康复服务和定义 "基本 "医疗保健方面具有灵活性。 本次研讨会将包括两个讲座,介绍加拿大目前在急性 SCI 康复和提供维持生命的 SCI 医疗服务、设备和用品方面的护理标准,随后将对其他可比国家的标准进行初步概述,并讨论下一步如何在加拿大发展 SCI 康复和提供 SCI 相关医疗需求方面的公平性和一致性。 完成本次研讨会后,与会者将了解
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引用次数: 0
Poster (Clinical/Best Practice Implementation) ID 1998248 海报(临床/最佳实践实施) ID 1998248
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-1998248s
P. Eftekhar, Dr. Cathy Craven, Sukhvinder Kalsy-Ryan
It is essential that individuals with spinal cord injury set their goals prior to their peripheral nerve transfer (PNT) surgery. Goal setting is a significant factor in pre-operative planning and is one way in which we can track performance and outcomes for these patients. To describe goal types identified by patients managed in the PNT-SCI rehab program at Lyndhurst-UHN. Cite and report the COPM outcomes in the domains of Self-care and Productivity. A retrospective case series was conducted (n=14), charts were reviewed for type of goals and patient’s perception of goal attainment using COPM for a case series of three patients with tetraplegia who received PNT-SCI surgery and comprehensive rehabilitation. The changes in COPM are reported from baseline to 12 months post-surgery. Each patient identified three goals pre-surgery; their goals and the COPM were used to measure change over time. Ninety two percent of the identified goals were in the area of Self Care, and 8% were in the Productivity areas. Two of the patients who received PNT-SCI rehabilitation had an increase of 1 on the COPM, while one individual regressed by 2 points. That individual did not receive comprehensive rehabilitation. It is known that recovery after PNT-SCI surgery can take 24 or more months. We reported COPM change scores at 12 months post surgery. The MCID is two points for COPM, ideally over 24 months we will see MCID of three or higher.
脊髓损伤患者在进行周围神经转移(PNT)手术之前,必须设定自己的目标。目标设定是术前规划的一个重要因素,也是我们跟踪这些患者的表现和结果的一种方法。 描述林德赫斯特-UHN 的 PNT-SCI 康复项目管理的患者所确定的目标类型。引用并报告自理能力和生产力领域的 COPM 成果。 对接受了PNT-SCI手术和综合康复治疗的三名四肢瘫痪患者的病历进行了回顾性病例系列分析(n=14),以了解目标类型和患者使用COPM实现目标的情况。报告了 COPM 从基线到术后 12 个月的变化情况。每位患者在手术前都确定了三个目标;他们的目标和 COPM 被用来衡量随时间推移而发生的变化。 在确定的目标中,92% 属于自我护理领域,8% 属于生产力领域。在接受 PNT-SCI 康复治疗的患者中,有两人的 COPM 上升了 1 分,而有一人则下降了 2 分。该患者没有接受全面康复治疗。 众所周知,PNT-SCI 手术后的恢复需要 24 个月或更长时间。我们报告了术后 12 个月的 COPM 变化分数。COPM 的 MCID 为 2 分,理想情况下,在 24 个月内我们将看到 MCID 达到 3 分或更高。
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引用次数: 0
Post-Doc Competition (Knowledge Generation) ID 1985177 博士后竞赛(知识创造) ID 1985177
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-1985177s
Philemon Tsang, Wagner H. Souza, Thomas P. Walden, M. Miyatani, Cathy Craven
Heart Disease is the leading cause of death after spinal cord injury (SCI). Individuals with paraplegia develop hypertension and elevated arterial stiffness prior to their age matched peers. Overground exoskeleton training is becoming an increasingly prevalent form of exercise. In the general population, exercise training has been shown to reduce arterial stiffness. Recent RCT failed to show changes in arterial stiffness with arm ergometry or body weight supported treadmill training. The aim of this project is to determine the effect of Exoskeleton Exercise on changing arterial stiffness. The study setting will take place at a rehabilitation facility. The study will involve 34 sessions over the span of approximately 18-20 weeks. The key intervention utilized in the investigation will be an Overground EksoNR gait and balance training program. The primary outcome measure will be carotid-femoral pulse wave velocity (cfPWV) and secondary measures will include heart rate (HR), blood pressure (BP), waist circumference (WC), and oxygen saturation (SpO2). Statistical Analysis will involve mean changes at baseline, midway, and end of study. The 34-session (2x/week for ∼18 weeks) rehabilitation protocol will focus on using the EksoNR for overground gait and balance activities. For measurement of cfPWV, two transcutaneous Doppler flowmeters will be used at the common carotid and femoral artery. To calculate cfPWV, the distance travelled by the pulse is divided by the average pulse transit time (PTT). The 18-week Exoskeleton Program would improve arterial stiffness (cfPWV) in individuals with chronic incomplete SCI/D.
心脏病是脊髓损伤(SCI)后死亡的主要原因。截瘫患者比同龄人更早出现高血压和动脉僵化。地面外骨骼训练正成为一种日益普遍的锻炼方式。在普通人群中,运动训练已被证明可以降低动脉僵化。最近进行的研究调查显示,臂力测定法或体重支持跑步机训练未能改变动脉僵化。 本项目旨在确定外骨骼运动对改变动脉僵化的效果。 研究将在一家康复机构进行。研究将涉及 34 个疗程,时间跨度约为 18-20 周。调查中使用的主要干预措施是地面 EksoNR 步态和平衡训练计划。主要测量指标是颈动脉-股动脉脉搏波速度(cfPWV),次要测量指标包括心率(HR)、血压(BP)、腰围(WC)和血氧饱和度(SpO2)。统计分析将包括基线、中途和研究结束时的平均变化。 为期 34 次(每周 2 次,每次 18 周)的康复方案将侧重于使用 EksoNR 进行地面步态和平衡活动。为测量 cfPWV,将在颈总动脉和股动脉处使用两个经皮多普勒血流测量仪。要计算 cfPWV,需要将脉搏走过的距离除以平均脉搏传输时间(PTT)。 为期 18 周的外骨骼计划将改善慢性不完全 SCI/D 患者的动脉僵硬度(cfPWV)。
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引用次数: 0
Student Competition (Technology Innovation) ID 1985155 学生竞赛(技术创新) ID 1985155
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-1985155s
Amin Arefadib, Pouria Faridi, Soroush Mirkiani, Ashley Dalrymple, Vivian K. Mushahwar
ISMS entails implanting micro-electrodes into the spinal cord to produce synergistic activations of the legs. To date, ISMS has produced in-place stepping in cats with complete spinal cord injury (SCI) (Saigal et al, 2004), and long distances of over ground walking in anesthetized cats (Holinski et al, 2016). The goal of this project is to develop an intervention for restoring overground walking capacity for persons experiencing paralysis due to SCI, by investigating the potential of ISMS to enable long-distance overground walking in cats with chronic SCI. Experiments will be performed in eight adult cats with chronic complete SCI. The control strategy will include timed transitions between different phases of the step cycle, which will be modified using feedback from force plates and gyroscopes. The biomechanics of walking (speed of walking, stride length, left-right symmetry, inter-joint coordination) and muscle activation patterns will be recorded and analyzed. The stride-to-stride regularity of walking, amount of weight-bearing, and level of spasticity before, during, and after ISMS will be assessed. We expect that ISMS will produce long distances of walking (>500 m) in cats with SCI. The biomechanical features of walking will be similar to those in neurologically-intact cats. This project is a critical step towards demonstrating the viability of ISMS as a means for restoring functional walking after severe SCI. If successful, ISMS and the control strategies developed may in the future change the lives of many people living with SCI, giving them the capability to walk independently.
ISMS 需要将微电极植入脊髓,以产生腿部的协同激活。迄今为止,ISMS 已经在完全脊髓损伤(SCI)的猫身上产生了原地踏步的效果(Saigal 等人,2004 年),并在麻醉猫身上产生了长距离地面行走的效果(Holinski 等人,2016 年)。 本项目的目标是通过研究 ISMS 在慢性 SCI 猫中实现长距离地面行走的潜力,开发一种干预措施,以恢复因 SCI 而瘫痪者的地面行走能力。 实验将在 8 只患有慢性完全性 SCI 的成年猫身上进行。控制策略将包括步周期不同阶段之间的定时转换,并将利用力板和陀螺仪的反馈进行修改。将记录和分析行走的生物力学(行走速度、步幅、左右对称性、关节间协调性)和肌肉激活模式。在 ISMS 之前、期间和之后,还将对步行的步幅规律性、负重量和痉挛程度进行评估。 我们希望 ISMS 能让 SCI 猫实现长距离行走(>500 米)。行走的生物力学特征将与神经系统完好的猫相似。 该项目是证明 ISMS 作为严重 SCI 后恢复功能性行走的一种手段的可行性的关键一步。如果成功,ISMS 和所开发的控制策略将来可能会改变许多 SCI 患者的生活,使他们具备独立行走的能力。
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引用次数: 0
Poster (Clinical/Best Practice Implementation) ID 2004605 海报(临床/最佳实践实施)ID 2004605
IF 2.9 Q1 REHABILITATION Pub Date : 2023-09-01 DOI: 10.46292/sci23-2004605s
James Milligan, Joseph Lee, Allison Harrison, Kathleen MacGregor
The Centre for Family Medicine Mobility Clinic strives to provide high quality primary care to persons living with spinal cord injury or other health conditions that affect mobility. The Mobility Clinic Resource Abilities Council (MC RAC) was established to serve in an advisory capacity, making recommendations on matters that impact the experience of patients with physical disabilities and their support persons at the Mobility Clinic. MC RAC provides feedback on, and ideas for initiatives and programs that support and enhance the model of person-centred care. It also advances collaborative patient engagement and person-centred care principles and practices within primary care for persons with physical disabilities Members include individuals with lived experience with physical disability, their support persons, and Mobility Clinic staff. The council was established August 2022 and meets virtually once per month for approximately 90 minutes. MC RAC has successfully met nine times and has provided feedback on the following topics: Breast & Cervical Cancer screening Initiative for People with Physical Disabilities, Mobility Clinic website development, building pathways for advocacy with the KW4 OHT, Circulus Network webinar topics, Mobility Clinic organization and clinical flow. Feedback to be implemented into Mobility Clinic activities. Patient and support persons involvement in decision-making processes improve care experiences and contribute to better health outcomes for patients. We will continue to work and develop our patient advisory council to better support the Mobility Clinic’s patients and their support persons.
家庭医学中心行动诊所致力于为脊髓损伤或其他影响行动的健康状况的患者提供高质量的初级医疗服务。流动诊所资源能力委员会(MC RAC)的成立旨在发挥咨询作用,就影响肢体残疾患者及其辅助人员在流动诊所就医体验的事项提出建议。 该委员会就支持和加强以人为本的护理模式的措施和计划提供反馈和建议。该委员会还在为肢体残障人士提供初级医疗服务的过程中,促进患者的合作参与以及以人为本的护理原则和实践。 委员会成员包括具有肢体残障生活经验的个人、他们的辅助人员以及行动诊所的员工。理事会于 2022 年 8 月成立,每月召开一次虚拟会议,会议时间约为 90 分钟。 管委会康复咨询委员会已成功召开了九次会议,并就以下主题提供了反馈意见:肢体残疾人乳腺癌和宫颈癌筛查倡议、行动诊所网站开发、与 KW4 OHT 建立宣传途径、Circulus 网络研讨会主题、行动诊所组织和临床流程。将在行动诊所活动中落实反馈意见。 患者和辅助人员参与决策过程可改善护理体验,有助于改善患者的健康状况。我们将继续努力,发展我们的患者咨询委员会,为行动诊所的患者及其辅助人员提供更好的支持。
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Topics in Spinal Cord Injury Rehabilitation
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