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CCCC News 预备的新闻
0 LITERATURE Pub Date : 2023-07-01 DOI: 10.58680/ccc202332525
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引用次数: 0
First-Year International Students and the Language of Indigenous Studies 一年级国际学生与土著语言研究
0 LITERATURE Pub Date : 2023-02-01 DOI: 10.58680/ccc202332365
Katja Thieme, Jennifer Walsh Marr
We advocate for the inclusion of Indigenous studies within first-year writing and academic English courses, particularly those taught to multilingual, international students. We argue that asking international students to learn about local and international Indigenous issues productively intersects with coursework in academic English. Our pedagogical approach emphasizes metalanguage and allows Indigenous studies and explicit language instruction to work in tandem, thereby recognizing the agency of Indigenous scholars and guiding non-Indigenous students in relation to it.
我们提倡将土著研究纳入第一年的写作和学术英语课程,特别是那些面向多语种国际学生的课程。我们认为,要求国际学生学习当地和国际土著问题与学术英语课程有建设性的交叉。我们的教学方法强调元语言,并允许土著研究和明确的语言教学协同工作,从而认识到土著学者的作用,并指导非土著学生与之相关。
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引用次数: 1
The Student-Podcaster as Narrator of Social Change? 学生播客作为社会变革的叙述者?
0 LITERATURE Pub Date : 2023-02-01 DOI: 10.58680/ccc202332366
Phil Choong, Collin Bjork
Podcasting has been used by many scholars to teach ancient and contemporary rhetorical principles. We extend this conversation by examining narrative nonfiction podcasting and its potential to work toward social change. We suggest pedagogical principles that amplify the affordances of the genre and acknowledge its constraints for achieving social change.
播客已经被许多学者用来教授古代和当代的修辞原则。我们通过研究叙事性非虚构播客及其促进社会变革的潜力来扩展这一对话。我们建议的教学原则是扩大这一类型的启示,并承认它对实现社会变革的限制。
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引用次数: 0
Announcements and Calls 公告及电话
0 LITERATURE Pub Date : 2023-02-01 DOI: 10.58680/ccc202332369
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引用次数: 0
The Virtual Writing Marathon Ecosystem: Writing, Community, and Emotion 虚拟写作马拉松生态系统:写作、社区和情感
0 LITERATURE Pub Date : 2023-02-01 DOI: 10.58680/ccc202332363
Kelly Sassi, Susan Martens, Richard Louth
This empirical study of a virtual writing marathon (Write Across America) theorizes a dynamic online ecosystem in which the five realms—virtual place, design, writing, sharing, and emotion—interact in the process of writing. The study has implications for students and for the professional development of writing instructors.
这项对虚拟写作马拉松(Write Across America)的实证研究将一个动态的在线生态系统理论化,在这个生态系统中,五个领域——虚拟空间、设计、写作、分享和情感——在写作过程中相互作用。该研究对学生和写作教师的专业发展具有启示意义。
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引用次数: 0
Thinking about Feeling: The Roles of Emotion in Reflective Writing 思考情感:情感在反思性写作中的作用
0 LITERATURE Pub Date : 2023-02-01 DOI: 10.58680/ccc202332364
Elizabeth Ellis Miller, Cameron Mozafari, Justin Lohr, Jessica Enoch
Drawing from a qualitative study, we share findings that demonstrate how students articulate and express emotion in reflection. As they reflect on their writing identities, processes and products, peer and instructor feedback, and assess their work, the students in our study routinely discuss their emotions. Our essay closes with pedagogical strategies for helping students reflect on their thinking and feeling about writing.
从一项定性研究中,我们分享了学生如何在反思中表达情感的发现。在我们的研究中,学生们在反思他们的写作身份、过程和成果、同伴和导师的反馈以及评估他们的工作时,经常讨论他们的情绪。我们的文章以帮助学生反思他们对写作的思考和感受的教学策略结束。
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引用次数: 0
CCCC News 预备的新闻
0 LITERATURE Pub Date : 2023-02-01 DOI: 10.58680/ccc202332368
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引用次数: 0
Audience Awareness and Access: The Design of Sound and Captions as Valuable Composition Practices 观众意识和访问:声音和字幕作为有价值的作曲实践的设计
0 LITERATURE Pub Date : 2023-02-01 DOI: 10.58680/ccc202332362
Janine Butler, Stacy Bick
To demonstrate the value of access and attending to audiences’ experiences, this article shares our analysis of our interviews with eleven students who created videos with sound and captions. We build on our analysis to present a modified set of criteria for assessing how video composers demonstrate awareness of their audiences’ needs and preferences when designing access.
为了展示接触和参与观众体验的价值,本文分享了我们对11名学生的采访分析,他们制作了带有声音和字幕的视频。我们在分析的基础上提出了一套修改后的标准,用于评估视频作曲家在设计访问时如何表现出对受众需求和偏好的认识。
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引用次数: 0
Opinion: The Persistent “Reading Myth” and the “Crisis of the Humanities” 观点:持续的“阅读神话”与“人文危机”
0 LITERATURE Pub Date : 2023-02-01 DOI: 10.58680/ccc202332367
Harvey J. Graf
Preview this article: Opinion: The Persistent “Reading Myth” and the “Crisis of the Humanities”, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/ccc/74/3/collegecomposition32367-1.gif
预览本文:意见:持久的“阅读神话”和“人文危机”,1页1 <上一页|下一页> /docserver/ Preview /全文/ccc/74/3/collegecomposition32367-1.gif
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引用次数: 0
Proteasome activator 28γ (PA28γ) allosterically activates trypsin-like proteolysis by binding to the α-ring of the 20S proteasome. 蛋白酶体激活剂 28γ(PA28γ)通过与 20S 蛋白酶体的 α 环结合,异位激活胰蛋白酶样蛋白水解。
0 LITERATURE Pub Date : 2022-08-01 Epub Date: 2022-06-14 DOI: 10.1016/j.jbc.2022.102140
Taylor A Thomas, David M Smith

Proteasome activator 28γ (PA28γ/REGγ) is a member of the 11S family of proteasomal regulators that is constitutively expressed in the nucleus and implicated in various diseases, including certain cancers and systemic lupus erythematosus. Despite years of investigation, how PA28γ functions to stimulate proteasomal protein degradation remains unclear. Alternative hypotheses have been proposed for the molecular mechanism of PA28γ, including the following: (1) substrate selection, (2) allosteric upregulation of the trypsin-like (T-L) site, (3) allosteric inhibition of the chymotrypsin-like (CT-L) and caspase-like (C-L) sites, (4) conversion of the CT-L or C-L sites to new T-L sites, and (5) gate opening alone or in combination with a previous hypothesis. Here, by mechanistically decoupling gating effects from active site effects, we unambiguously demonstrate that WT PA28γ allosterically activates the T-L site. We show PA28γ binding increases the Kcat/Km by 13-fold for T-L peptide substrates while having little-to-no effect on hydrolysis kinetics for CT-L or C-L substrates. Furthermore, mutagenesis and domain swaps of PA28γ reveal that it does not select for T-L peptide substrates through either the substrate entry pore or the distal intrinsically disordered region. We also show that a previously reported point mutation can functionally switch PA28γ from a T-L activating to a gate-opening activator in a mutually exclusive fashion. Finally, using cryogenic electron microscopy, we visualized the PA28γ-proteasome complex at 4.3 Å and confirmed its expected quaternary structure. The results of this study provide unambiguous evidence that PA28γ can function by binding the 20S proteasome to allosterically activate the T-L proteolytic site.

蛋白酶体激活剂 28γ(PA28γ/REGγ)是蛋白酶体调节剂 11S 家族的一个成员,在细胞核中组成性表达,与多种疾病有关,包括某些癌症和系统性红斑狼疮。尽管经过多年的研究,PA28γ 如何发挥刺激蛋白酶体蛋白降解的功能仍不清楚。人们对 PA28γ 的分子机制提出了多种假设,包括以下几种:(1) 底物选择;(2) 胰蛋白酶样(T-L)位点的异构上调;(3) 糜蛋白酶样(CT-L)和类宿命酶(C-L)位点的异构抑制;(4) CT-L 或 C-L 位点转化为新的 T-L 位点;(5) 单独或与前一种假说相结合的闸门打开。在这里,通过从机理上解耦门控效应与活性位点效应,我们明确地证明了 WT PA28γ 异源激活了 T-L 位点。我们发现 PA28γ 的结合使 T-L 肽底物的 Kcat/Km 增加了 13 倍,而对 CT-L 或 C-L 底物的水解动力学几乎没有影响。此外,PA28γ 的诱变和结构域交换显示,它不会通过底物进入孔或远端本征无序区选择 T-L 肽底物。我们还发现,以前报道过的一个点突变可以在功能上将 PA28γ 从 T-L 激活因子转换为互斥的门开启激活因子。最后,利用低温电子显微镜,我们在 4.3 Å 处观察到了 PA28γ 蛋白酶体复合物,并证实了其预期的四元结构。这项研究的结果提供了明确的证据,证明 PA28γ 可通过结合 20S 蛋白酶体来异位激活 T-L 蛋白水解位点。
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引用次数: 0
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COLLEGE COMPOSITION AND COMMUNICATION
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