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Metastatic neck involvement in oral squamous cell carcinoma: A retrospective clinicopathological study. 口腔鳞状细胞癌转移性颈部受累:回顾性临床病理研究。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-16 DOI: 10.1007/s44445-025-00088-x
Medyan Al Rousan, Ra'ad Alsunna, Lamees AlKhalili, Jowan Al-Nusair, Raya Manasrah, Sumaiah H AlNaimat, Raed Dwaik, Lina Alelaumi, Jareer Shatnawi

Oral squamous cell carcinoma (OSCC) is the most common oral malignancy, with neck metastasis significantly affecting prognosis and treatment. This study examines clinicopathological factors associated with neck metastasis in a Middle Eastern cohort of OSCC patients. A retrospective analysis of 84 OSCC patients treated at King Hussein Cancer Center (2018-2024) was conducted. Clinicopathological factors, including tumor subsite, T stage, depth of invasion, differentiation, perineural invasion, and lymphovascular invasion were evaluated for their association with lymph node metastasis. Pathological neck involvement was observed in 47.6% of cases. Late T stage (T3-T4) and LVI positivity were identified as independent predictors of nodal metastasis (aOR = 4.25, p = 0.009; aOR = 4.39, p = 0.027, respectively). These findings highlight the importance of comprehensive pathological assessment in OSCC.

口腔鳞状细胞癌(Oral squamous cell carcinoma, OSCC)是最常见的口腔恶性肿瘤,颈部转移严重影响预后和治疗。本研究探讨了与中东一组OSCC患者颈部转移相关的临床病理因素。回顾性分析2018-2024年在侯赛因国王癌症中心治疗的84例OSCC患者。评估临床病理因素,包括肿瘤亚位、T分期、浸润深度、分化、神经周围浸润和淋巴血管浸润与淋巴结转移的关系。病理性颈部受累占47.6%。晚期T期(T3-T4)和LVI阳性是淋巴结转移的独立预测因子(aOR = 4.25, p = 0.009; aOR = 4.39, p = 0.027)。这些发现强调了全面病理评估在OSCC中的重要性。
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引用次数: 0
Temporomandibular joint manifestation of autoimmune diseases. 颞下颌关节自身免疫性疾病的表现。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-14 DOI: 10.1007/s44445-026-00118-2
Hamad Al-Bageah, Ahmed Al-Mousa, Belal Diri, Hashim Diri, Naif Al-Shayiqi, Mohammed Al-Khedheir, Jouhena Al-Mashhri

This research compilation examines the frequency and consequences of abnormalities in the temporomandibular joint (TMJ) associated with various autoimmune diseases, with an emphasis on arthritic conditions. When the immune system of the body unintentionally targets its own tissues, autoimmune illnesses arise. This causes inflammation and damage to several organs, including joints. This study describes how rheumatoid arthritis affects the TMJ and emphasize how it affects oral dysfunction; provide a preliminary report on TMJ involvement in Psoriasis, highlighting the need of early diagnosis and care. Our study investigates TMJ abnormalities in individuals who have psoriatic arthritis and osteoporosis, respectively. These findings suggest a complicated interaction between systemic health and TMJ function. We examined instances of TMJ ankylosis in patients with ankylosing spondylitis as well as the frequency of TMJ issues in this group of patients. We conducted a scoping review to gather information on the role of the TMJ in ankylosing spondylitis and to guide clinical practice. When taken as a whole, these studies highlight how important it is to use multidisciplinary techniques to treat TMJ issues in autoimmune illness patients in order to improve patient outcomes. This study aimed to evaluate the involvement of the TMJ in six specific autoimmune conditions which are, Rheumatoid arthritis, Juvenile idiopathic arthritis, Osteoporosis, Psoriasis, Ankylosing spondylitis and systemic lupus erythematous (SLE). A total of 24 research studies were included in the analysis, sourced from PubMed, Google scholar and web of science starting from 2003 to 2023. The selection criteria were based on relevance to TMJ manifestation, clinical significance, and peer-reviewed status. Data extraction focused on TMJ structural change, functional impairment, and the clinical outcomes associated with each autoimmune condition. Advanced imaging techniques, such as Cone Beam Computed Tomography (CBCT) were prioritized for assessing subtle bony changes not visible on conventional radiographic images.

本研究汇编检查了与各种自身免疫性疾病相关的颞下颌关节(TMJ)异常的频率和后果,重点是关节炎。当身体的免疫系统无意中以自身组织为目标时,自身免疫性疾病就会出现。这会导致包括关节在内的几个器官发炎和损伤。本研究描述了类风湿关节炎如何影响颞下颌关节,并强调它如何影响口腔功能障碍;提供银屑病颞下颌关节参与的初步报告,强调早期诊断和护理的必要性。我们的研究分别调查了银屑病关节炎和骨质疏松症患者的颞下颌关节异常。这些发现表明,系统健康和TMJ功能之间存在复杂的相互作用。我们检查了强直性脊柱炎患者的TMJ强直病例以及这组患者的TMJ问题的频率。我们进行了一项范围综述,以收集关于颞下颌关节在强直性脊柱炎中的作用的信息,并指导临床实践。作为一个整体,这些研究强调了使用多学科技术治疗自身免疫性疾病患者的TMJ问题以改善患者预后的重要性。本研究旨在评估TMJ在6种特定自身免疫性疾病(类风湿关节炎、幼年特发性关节炎、骨质疏松症、银屑病、强直性脊柱炎和系统性红斑狼疮(SLE))中的参与。该分析共纳入了24项研究,来自PubMed、b谷歌scholar和web of science,时间跨度为2003年至2023年。选择标准基于与TMJ表现的相关性、临床意义和同行评议状态。数据提取的重点是TMJ结构改变、功能损害以及与每种自身免疫性疾病相关的临床结果。先进的成像技术,如锥形束计算机断层扫描(CBCT)被优先用于评估传统放射图像上不可见的细微骨骼变化。
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引用次数: 0
Prevalence and associated factors of laboratory remakes in fixed prosthodontics: a multicenter audit in Riyadh, Saudi Arabia. 固定修复中实验室改造的患病率及相关因素:沙特阿拉伯利雅得的一项多中心审计。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-12 DOI: 10.1007/s44445-025-00110-2
Lubna Alkadi, Mohammed Alsuhaibani, Kadie Altuwaijri, Seba Alotaibi, Rawabi AlAlwan, Mohammed Almaymuni, Nawaf Al Muhyi, Fathima Fazrina Farook

Remakes in fixed prosthodontics present ongoing clinical and logistical challenges, including increased chairside time, laboratory costs, and patient dissatisfaction. Understanding the prevalence and causes of these remakes is essential for improving restorative outcomes and workflow efficiency. This study aimed to estimate the prevalence of laboratory remakes for fixed prosthodontic restorations and examine associations with restoration type, material, and operator classification in a multicenter setting. We conducted a retrospective, multicenter audit of 40,344 indirect restorations fabricated in seven dental laboratories in Riyadh. Predefined null hypotheses posited no associations between remake reasons and (a) restoration type, (b) material, or (c) operator classification. Pearson χ2 tests were used (α = 0.05). There were 2,612 remakes. By restoration, remake prevalence was veneers 7.5%, onlays 7.1%, crowns 6.9%, bridges 4.8%, and endocrowns 4.0%. Leading reasons were margin-fit discrepancy 29.5%, proximal-fit issue 23.2%, and improper fit 22.7%. Materials were differentially associated with remake reasons (e.g., shade mismatch more frequent with lithium-disilicate; proximal-fit problems more frequent with monolithic zirconia; all p < 0.05). Reason profiles differed by operator classification. Remakes were common and patterned by restoration type, material, and operator classification. Addressable targets include margins and proximal contacts, clearer laboratory prescriptions, and staged adoption of digital workflows with competency-based training. These observations can inform local quality-improvement initiatives.

固定修复术的重新制作带来了持续的临床和后勤挑战,包括增加的椅子时间、实验室成本和患者不满。了解这些重制的普遍性和原因对于改善修复结果和工作流程效率至关重要。本研究旨在评估固定义齿修复的实验室重做率,并在多中心环境中研究修复类型、材料和操作人员分类之间的关系。我们对利雅得7个牙科实验室制作的40344个间接修复体进行了回顾性多中心审计。预先设定的零假设假定在修复原因与(a)修复类型、(b)材料或(c)操作员分类之间没有关联。采用Pearson χ2检验(α = 0.05)。翻拍了2612部。修复后的重造率依次为贴面7.5%、全牙7.1%、冠6.9%、桥4.8%、内冠4.0%。主要原因为边际拟合差异(29.5%)、近端拟合问题(23.2%)和不合适拟合(22.7%)。材料与重制原因的相关性不同(例如,二硅酸锂的色度不匹配更频繁;单片氧化锆的近端拟合问题更频繁
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引用次数: 0
Knowledge of first-aid management of traumatic dental injuries among secondary school students in Central Poland: a cross-sectional study. 波兰中部中学生创伤性牙齿损伤的急救管理知识:一项横断面研究。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-11 DOI: 10.1007/s44445-026-00126-2
Karolina Spodzieja, Wiktoria Mól, Paula Piekoszewska-Ziętek, Marcin Studnicki, Dorota Olczak-Kowalczyk

Traumatic dental injuries (TDI) are a common problem especially in the field of paediatric dentistry and constitute a serious health issue in the young population. Prognosis of TDI treatment depend on various factors, for a long - term success immediate and proper first aid is crucial to preserve the vitality and function of damaged teeth. Since most cases of dental trauma occur at school - teachers and students are the first ones to encounter and to provide first aid in the emergency situation. Little attention is paid to educating primary and secondary school children about the first aid when the dental trauma occurs. The aim of our study was to investigate the knowledge of Polish secondary school students in management of traumatic injuries. A 34-item questionnaire on TDI experience and management was distributed amongst secondary school students attending different types of school in Poland. Statistical analyses were carried out using the IBM SPSS Statistics 25 package. It was used to perform Mann-Whitney's U tests, Kruskal-Wallis non-parametric ANOVA and Spearman's rank correlations. Two hundred and fifty eight questionnaires were obtained in the study. 76,7% of all responders have witnessed dental trauma in the past. 64,3% of them had suffered from TDI. Over 50% of students were unaware of a suitable medium in which to transport an avulsed permanent tooth. Only 32,2% decided that an avulsed tooth can be put back in its place. This study indicates a lack of adequate knowledge of management of TDI among secondary school students in Poland. Additional education about first aid of TDI should be developed and implemented. Appropriate first aid, emergency care at the accident site can save the patient more costly and time consuming treatment as well as negative health consequences including tooth loss.

创伤性牙齿损伤是一个常见的问题,特别是在儿科牙科领域,并构成了年轻人的严重健康问题。TDI治疗的预后取决于多种因素,为了长期成功,及时和适当的急救对保持受损牙齿的活力和功能至关重要。由于大多数牙齿外伤发生在学校,教师和学生是第一批遇到并在紧急情况下提供急救的人。中小学生发生牙外伤后的急救教育很少受到重视。本研究的目的是调查波兰中学生在创伤性损伤管理方面的知识。在波兰不同类型学校就读的中学生中分发了一份关于TDI经验和管理的34项问卷。采用IBM SPSS Statistics 25软件包进行统计分析。它被用来执行Mann-Whitney's U检验,Kruskal-Wallis非参数方差分析和Spearman's秩相关。该研究共获得258份调查问卷。76.7%的应答者在过去曾目睹过牙齿创伤。64.3%的人曾患过TDI。超过50%的学生不知道运送撕脱的恒牙的合适介质。只有32.2%的人认为撕脱的牙齿可以放回原位。本研究表明波兰中学生缺乏足够的TDI管理知识。应制定和实施关于TDI急救的额外教育。在事故现场进行适当的急救和紧急护理可以为患者节省更昂贵和耗时的治疗,并避免包括牙齿脱落在内的负面健康后果。
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引用次数: 0
The enamel loss and adhesive remnants after bracket removal and various adhesive removal methods: an in vitro experimental study. 托槽拔除后牙釉质流失和粘接剂残留及不同拔除方法的体外实验研究。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-10 DOI: 10.1007/s44445-026-00120-8
Farzaneh Ahrari, Hamideh Sadat Mohammadipour, Melika Hoseinzadeh, Hooman Shafaee, Amin Roshani

This study evaluated the effectiveness of various adhesive removal methods following orthodontic bracket debonding. Eighty extracted human premolars were bonded, debonded, and randomly assigned to four groups (n = 20) based on the adhesive removal method: (1) low-speed round tungsten carbide (TC) bur, (2) high-speed, 18-fluted tapered TC bur, (3) high-speed extra-fine needle-shaped diamond bur, and (4) sequential polishing discs. Each group was further subdivided into two subgroups (n = 10) based on the inspection method for surface cleanliness: tactile examination with a dental explorer or marking the surface with a black pencil. Adhesive removal time was recorded for each group, and surface roughness was measured. Pre- and post-treatment tooth surface scans were superimposed using Geomagic Wrap software to quantify enamel loss and residual adhesive height. Data were analyzed using two-way ANOVA (α = 0.05). The 18-fluted TC bur had the shortest adhesive removal time (52.80 ± 6.74 s) but caused the greatest enamel loss (70.56 ± 56.44 μm) and highest residual adhesive height (75.60 ± 57.35 μm) (P < 0.05). Surface roughness was significantly higher in the 18-fluted TC bur group (186.20 ± 65.98 μm) than in the polishing disc (123.70 ± 40.64 μm) group (P < 0.05). Adhesive removal time was significantly longer for the polishing disc group (P < 0.05). Using a black pencil for surface inspection did not affect enamel characteristics, but significantly increased treatment time (P < 0.001). A low-speed round-shaped TC bur or an extra-fine needle-shaped diamond bur is recommended for adhesive removal after bracket debonding. Enamel inspection with a dental explorer provides comparable results to black pencil marking regarding enamel preservation.

本研究评估正畸托槽脱粘后各种黏合剂去除方法的有效性。将取出的80颗人类前磨牙进行粘接、脱粘,并根据粘接去除方法随机分为4组(n = 20):(1)低速硬质合金(TC)圆钎,(2)高速18槽锥形碳化钨钎,(3)高速超细针状金刚石钎,(4)顺序抛光盘。根据表面清洁度的检查方法,将每组进一步分为两个亚组(n = 10):用牙齿探针触觉检查或用黑色铅笔标记表面。记录各组的去胶时间,并测量表面粗糙度。使用Geomagic Wrap软件对治疗前后的牙齿表面扫描进行叠加,以量化牙釉质损失和残余粘接剂高度。数据采用双因素方差分析(α = 0.05)。18槽TC牙槽脱粘时间最短(52.80±6.74 s),但牙釉质损失最大(70.56±56.44 μm),残留粘接高度最高(75.60±57.35 μm) (P . 427)
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引用次数: 0
What is the impact of titanium base versus multi-unit abutments on immediate loading outcomes: a systematic review. 钛基与多单元基台对即刻加载结果的影响:一项系统综述。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-31 DOI: 10.1007/s44445-025-00114-y
Hossein Salehivaziri, Sahar Molaei, Soroush Kazemi, Narges Shojaei

Purpose: This systematic review, conducted per PRISMA guidance, evaluated clinical outcomes of titanium-base (TiB) versus multi-unit (MU) abutments in immediate-loading dental implant protocols, focusing on implant survival, prosthetic and biological complications, and patient-reported outcomes.

Methods: PubMed and Scopus were searched for original English-language clinical studies published between 2001 and 2025, including RCTs, cohort studies, and clinical series with at least 12 months of follow-up. Only studies evaluating TiB and MU abutments in immediate-loading protocols were included. Due to heterogeneity in study designs, case selection, outcome measures, and follow-up duration, a narrative descriptive synthesis was performed without pooled statistical analysis.

Results: Seventeen clinical studies met the inclusion criteria. Both TiB and MU abutments showed high implant survival rates, generally in the high 90 s. TiB abutments performed well in single-tooth anterior restorations, showing fewer mechanical complications and better esthetic ratings. MU abutments were predominantly used in full-arch cases, demonstrating reliable long-term function but with higher mechanical maintenance needs. Marginal bone loss remained within acceptable limits across studies. Patient-reported outcomes were inconsistently assessed, though TiB tended to score higher for esthetics and MU for functional comfort.

Conclusions: Both TiB and MU abutments effectively support immediate loading when primary stability and proper prosthetic planning are achieved. TiB may be preferable for esthetic single-tooth cases, while MU abutments remain suitable for full-arch rehabilitation. The limited number of head-to-head studies highlights the need for well-designed randomized trials with standardized outcomes and validated patient-reported measures.

目的:本系统综述根据PRISMA指南进行,评估钛基基(TiB)与多单元(MU)基台在即刻加载牙种植体方案中的临床结果,重点关注种植体存活、假体和生物学并发症以及患者报告的结果。方法:检索2001年至2025年间发表的原始英文临床研究,包括随机对照试验、队列研究和随访至少12个月的临床系列研究。仅包括在立即加载方案中评估TiB和MU基台的研究。由于研究设计、病例选择、结果测量和随访时间的异质性,在没有汇总统计分析的情况下进行了叙述性描述性综合。结果:17项临床研究符合纳入标准。TiB和MU基牙均显示出较高的种植体存活率,一般在90多岁。TiB基台在单牙前牙修复中表现良好,机械并发症少,美观度高。MU基台主要用于全拱病例,表现出可靠的长期功能,但机械维护需求较高。所有研究表明,边际骨质流失仍在可接受的范围内。患者报告的结果评估不一致,尽管TiB在美学上得分更高,MU在功能舒适度上得分更高。结论:TiB和MU基台均可在获得初步稳定和适当的假体规划时有效地支持即时负载。xb可能更适合美观的单牙病例,而MU基台仍然适合全弓康复。数量有限的面对面研究强调了设计良好的随机试验的必要性,这些试验具有标准化的结果和经过验证的患者报告的措施。
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引用次数: 0
Surgical versus non-surgical canine exposure in the management of impacted canines in Orthodontic patients: retrospective analysis in Southern region of Najran, Kingdom of Saudi Arabia. 手术与非手术犬暴露治疗正畸患者牙阻生:沙特阿拉伯王国纳吉兰南部地区的回顾性分析
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-27 DOI: 10.1007/s44445-025-00116-w
S Al Mutalaq, R O Braimah, H Alshareef, M Alqadi, A S Alwalah, A N Almerdef, S S Albaaltahin

Canine teeth are essential to dentofacial aesthetics and functional harmony. When impacted they impair both form and function leading to psychological distress and poor health-related quality of life. This study investigates the approaches to managing impacted canines in the southern region of Najran, Kingdom of Saudi Arabia. This was a retrospective study with data collection from Najran Specialty Regional Dental Center in Najran, Kingdom of Saudi Arabia from 2020 to 2024. Clinical record data extracted include age, sex, radiographs, position of impacted canine, location of impacted canine and management protocol. The data were analyzed using IBM SPSS Statistics for IOS Version 25 (Armonk, NY: IBM Corp). P-value ≤ 0.05 was considered statistically significant. A total of 98 patients comprising 44 males (44.9%) and 54 females (55.1%) with impacted canines were managed during the study period. Age ranged from 13 to 30 years with mean ± SD age of 19.3 ± 3.3 years. Age group 16-20 years were in the majority (56 (57.1%)) while age group 26-30 were the least (3 (3.1%)). The majority of the impacted canines were located in the maxilla (85 (86.7%). Considering, management protocol, the majority (57 (58.2%)) of the patients with impacted canine were treated by non-surgical canine exposure. Most of our patients are young adults with the majority having maxillary canine impaction in the palatal location. Our favorite option is non-surgical canine exposure. Treatment durations ranges from two to four years with the majority in the 2.5 to 3 years.

犬齿对牙面美观和功能和谐至关重要。当受到影响时,它们会损害形式和功能,导致心理困扰和与健康相关的生活质量差。本研究调查了沙特阿拉伯王国纳季兰南部地区受影响犬类的管理方法。这是一项回顾性研究,收集了2020年至2024年沙特阿拉伯王国纳季兰纳季兰专业区域牙科中心的数据。提取的临床记录数据包括年龄、性别、x线片、患牙位置、患牙位置和处理方案。使用IBM SPSS Statistics for IOS Version 25 (Armonk, NY: IBM Corp .)对数据进行分析。p值≤0.05认为有统计学意义。在研究期间共处理了98例患患犬,其中男性44例(44.9%),女性54例(55.1%)。年龄13 ~ 30岁,平均±SD年龄19.3±3.3岁。16 ~ 20岁以56例(57.1%)居多,26 ~ 30岁最少(3例(3.1%))。多数阻生犬位于上颌骨(85只,占86.7%)。考虑到治疗方案,大多数(57例(58.2%))患者采用非手术犬暴露治疗。我们的大多数患者是年轻的成年人,大多数在腭位置有上颌犬牙嵌塞。我们最喜欢的选择是非手术犬暴露。治疗持续时间从2年到4年不等,大多数在2.5年到3年之间。
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引用次数: 0
Evaluation of SMART technique using Nano-silver fluoride and Silver Diamine Fluoride; evaluation of tooth discoloration and shear bond strength in primary molars. 纳米氟化银和氟化二胺银的SMART技术评价初生磨牙牙齿变色及剪切黏结强度之评估。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-26 DOI: 10.1007/s44445-025-00107-x
Eman A Bakhurji, Rasha Al Sheikh, Abdullah A Alamri, Firas A Alothman, Khalid E Aldossary, Fayez R Alghamdi, Osama S Alghamdi

The aim of this study was to evaluate the shear bond strength and tooth discoloration of resin-modified glass ionomer cement (RMGIC) and high-viscosity glass ionomer cement (HGIC) restorations in primary teeth treated with either nano-silver fluoride (NSF) or silver diamine fluoride (SDF). Sixty-six primary molars with dentin caries were randomly assigned to six groups of 11 teeth each: two NSF-treated groups (one RMGIC, one HGIC) and two SDF-treated groups (one RMGIC, one HGIC). Two additional control groups received direct RMGIC and HGIC restorations, respectively. All samples were tested for tooth discoloration using a spectrophotometer before and after the thermocycling aging process (20,000 cycles). Shear bond strength was compared between the groups. Kruskal-Wallis test with a P-value of < 0.05 was used for statistical significance. The samples treated with SDF and restored with RMGIC exhibited the highest ΔE value (mean ± standard deviation (SD) of 8.27 ± 6.51). In contrast, the samples treated with NSF and restored with RMGIC demonstrated the lowest ΔE value (mean ± SD of 1.45 ± 0.77). No statistically significant differences were found between the groups in the shear bond strength test. NSF provided a better color masking effect compared to SDF when using RMGIC without visible black stains through the restoration. Additionally, neither NSF nor SDF affected the shear bond strength of either type of restoration applied to them. NSF may be preferred over SDF in cases where aesthetics is a priority, with similar bond strength and enhanced color matching.

本研究的目的是评估树脂改性玻璃离子水门合剂(RMGIC)和高粘度玻璃离子水门合剂(HGIC)在纳米氟化银(NSF)或氟化二胺银(SDF)治疗的乳牙的剪切粘结强度和牙齿变色情况。将66颗牙本质龋病的初生磨牙随机分为6组,每组11颗牙:2个nsf治疗组(1个RMGIC, 1个HGIC)和2个sdf治疗组(1个RMGIC, 1个HGIC)。另外两个对照组分别接受直接RMGIC和HGIC修复。在热循环老化过程(20,000循环)前后,使用分光光度计测试所有样品的牙齿变色情况。比较各组间的剪切粘结强度。Kruskal-Wallis检验,p值为
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引用次数: 0
Do irrigating solutions influence the cyclic fatigue resistance of heat-treated NiTi instruments? an in vitro study. 冲洗液是否影响热处理NiTi仪器的抗循环疲劳性能?一项体外研究。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-23 DOI: 10.1007/s44445-025-00093-0
Christoph Matthias Schoppmeier, Malin Janson, Li Sun, Gustav Leo Classen, Anna Greta Barbe

Purpose: Nickel-titanium (NiTi) instruments have advanced root canal preparation through enhanced precision. Thermal pretreatment improves both flexibility and cyclic fatigue resistance (CFR). While irrigating solutions are essential for decontamination, they may also affect the properties of heat-treated NiTi instruments. This study aimed to evaluate the impact of different irrigating solutions on the cyclic fatigue resistance of heat-treated NiTi files.

Methods: Four heat-treated reciprocating NiTi-files were analyzed: EdgeOne R-Utopia, Reciproc Blue, Procodile Q and CC One Blue. Files were immersed (5 min; 37 °C and 60 °C) in 5.25% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 96% ethanol, NaOCl + EDTA, distilled water, or left in a no-immersion control group. CFR was measured in an artificial root canal (60° curvature, 5 mm radius), and fragment length (FL) was documented. The surface features of the fragments were assessed through scanning electron microscopy.

Results: File system, irrigating solution, and temperature significantly influenced CFR (p < 0.001). Across all immersion conditions, the CFR reached its highest value with Procodile Q (37 °C distilled water) and its lowest with EdgeOne R-Utopia (60 °C NaOCl + EDTA). EDTA reduced CFR across all files, particularly at elevated temperatures and when combined with NaOCl. Microscopy revealed micropitting and roughened surfaces, particularly on CC One Blue (60 °C NaOCl), as well as material degradation and heterogeneous surfaces with NaOCl + EDTA.

Conclusions: Heat-treated NiTi instruments are influenced in their mechanical and metallurgical behavior by the chemical and thermal impact of irrigating solutions. Heated EDTA and NaOCl + EDTA were detrimental, while Procodile Q demonstrated the highest CFR. Within the limitations of this study, exposure to irrigating solutions, particularly heated EDTA and NaOCl + EDTA, reduced the cyclic fatigue resistance of heat-treated NiTi files. Clinically, prudent selection and temperature control of irrigants may help preserve instrument performance and reduce the risk of file fracture during root canal preparation.

目的:镍钛(NiTi)器械提高了根管预备的精度。热预处理提高了材料的柔韧性和抗循环疲劳性能。虽然冲洗溶液对于去污是必不可少的,但它们也可能影响热处理镍钛仪器的性能。本研究旨在评价不同灌洗溶液对热处理NiTi锉的抗循环疲劳性能的影响。方法:对EdgeOne R-Utopia、Reciproc Blue、procoile Q、CC One Blue四种热处理往复锉进行分析。将文件浸泡在5.25%次氯酸钠(NaOCl)、17%乙二胺四乙酸(EDTA)、96%乙醇、NaOCl + EDTA、蒸馏水中(5分钟,37℃和60℃),或不浸泡对照组。在人工根管(60°曲率,5mm半径)中测量CFR,并记录碎片长度(FL)。通过扫描电镜对碎片的表面特征进行了评估。结果:文件系统、冲洗液和温度对CFR有显著影响(p)。结论:热处理NiTi仪器的力学和冶金性能受冲洗液的化学和热影响。加热EDTA和NaOCl + EDTA均有害,而procodiile Q的CFR最高。在本研究的限制范围内,暴露于灌溉溶液,特别是加热EDTA和NaOCl + EDTA,降低了热处理NiTi锉的抗循环疲劳性。临床上,谨慎选择和控制冲洗液的温度有助于保持器械的性能,减少根管准备过程中锉断裂的风险。
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引用次数: 0
Preparation of clove extract-loaded nano-hydroxyapatite for combating dental caries-associated microbes. 丁香提取物纳米羟基磷灰石抗龋微生物的制备。
IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-23 DOI: 10.1007/s44445-026-00121-7
Abdulrazzaq Hammal, Heba Al-Hamed Al-Duihi

The global rise in antibiotic resistance among oral pathogens necessitates exploring natural and innovative alternatives for dental caries management. This study aimed to synthesize, characterize, and evaluate a novel clove extract-loaded nano-hydroxyapatite composite (nHA-CE) for its dual functionality: biomimetic remineralization and enhanced antimicrobial activity against dental caries-associated microbes. Nano-hydroxyapatite (nHA) was synthesized via wet chemical precipitation and characterized using XRD, FTIR, AFM, and DLS. Clove extract was obtained by ethanolic extraction and analyzed by GC-MS. The nHA-CE composite was prepared, and its antibacterial efficacy was tested against oral pathogens using agar well diffusion and compared to standard antibiotics. The nHA particles were spherical, with an average size of ~ 80 nm. Eugenol (72.5%) was the major component in clove extract. The nHA-CE composite showed significantly larger inhibition zones against all pathogens, especially Streptococcus mutans (50 ± 0.8 mm), outperforming conventional antibiotics. The composite also exhibited sustained eugenol release and maintained stability over 30 days. The nHA-CE composite is a promising biomaterial for dental caries prevention, combining effective remineralization with potent, broad-spectrum antimicrobial activity, offering a natural alternative to conventional treatments.

口腔病原体抗生素耐药性的全球上升需要探索自然和创新的龋齿管理替代方案。本研究旨在合成、表征和评价一种新型丁香提取物负载纳米羟基磷灰石复合材料(nHA-CE)的双重功能:仿生再矿化和增强对龋齿相关微生物的抗菌活性。采用湿法化学沉淀法合成了纳米羟基磷灰石(nHA),并用XRD、FTIR、AFM和DLS对其进行了表征。用乙醇提取得到丁香提取物,并采用气相色谱-质谱分析。制备nHA-CE复合材料,采用琼脂孔扩散法检测其对口腔病原菌的抗菌效果,并与标准抗生素进行比较。nHA颗粒呈球形,平均粒径为~ 80 nm。丁香酚是丁香提取物的主要成分,占72.5%。nHA-CE复合物对所有病原菌均有较大的抑制区,尤其是变形链球菌(50±0.8 mm),优于常规抗生素。该复合材料还表现出持续的丁香酚释放,并在30天内保持稳定。nHA-CE复合材料是一种很有前途的预防龋齿的生物材料,结合了有效的再矿化和有效的广谱抗菌活性,为传统治疗提供了一种天然的替代方案。
{"title":"Preparation of clove extract-loaded nano-hydroxyapatite for combating dental caries-associated microbes.","authors":"Abdulrazzaq Hammal, Heba Al-Hamed Al-Duihi","doi":"10.1007/s44445-026-00121-7","DOIUrl":"10.1007/s44445-026-00121-7","url":null,"abstract":"<p><p>The global rise in antibiotic resistance among oral pathogens necessitates exploring natural and innovative alternatives for dental caries management. This study aimed to synthesize, characterize, and evaluate a novel clove extract-loaded nano-hydroxyapatite composite (nHA-CE) for its dual functionality: biomimetic remineralization and enhanced antimicrobial activity against dental caries-associated microbes. Nano-hydroxyapatite (nHA) was synthesized via wet chemical precipitation and characterized using XRD, FTIR, AFM, and DLS. Clove extract was obtained by ethanolic extraction and analyzed by GC-MS. The nHA-CE composite was prepared, and its antibacterial efficacy was tested against oral pathogens using agar well diffusion and compared to standard antibiotics. The nHA particles were spherical, with an average size of ~ 80 nm. Eugenol (72.5%) was the major component in clove extract. The nHA-CE composite showed significantly larger inhibition zones against all pathogens, especially Streptococcus mutans (50 ± 0.8 mm), outperforming conventional antibiotics. The composite also exhibited sustained eugenol release and maintained stability over 30 days. The nHA-CE composite is a promising biomaterial for dental caries prevention, combining effective remineralization with potent, broad-spectrum antimicrobial activity, offering a natural alternative to conventional treatments.</p>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"38 2","pages":"9"},"PeriodicalIF":2.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Saudi Dental Journal
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