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Chronic Suppurative Osteomyelitis of the Mandibular Condyle in Children as a Sequel to Dental Extraction: A Case Report with Review of Literature. 拔牙后儿童下颌髁慢性化脓性骨髓炎1例并文献复习。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-07-07 DOI: 10.1007/s12663-025-02675-1
Anand Mohan Nikunj, Biswajit Mishra, Bathri Elangovan, Sonalee Shah

Introduction: Chronic suppurative osteomylities (CSO) in maxillofacial region most commonly affects mandible and involvement of condyle and coronoid is uncommon. CSO in children is usually misdiagnosed and not treated properly.

Case report: We present a girl child reported with swelling and pus discharge near preauricular region. She had history of extraction in mandible and recurrent swelling and trismus in the past.

Treatment: The case was diagnosed as chronic suppurative osteomyelitis and sequestrectomy was done under general anaesthesia.

Outcome: CSO involving condyle and coronoid is uncommon in children which makes it a unique case. Awareness regarding osteomyelitis in children should be encouraged more in rural areas so that diagnosis and prompt treatment can be given at the earliest.

摘要颌面部慢性化脓性骨病(CSO)最常累及下颌骨,累及髁突和冠突少见。儿童CSO常被误诊,治疗不当。病例报告:我们报告了一个女孩的肿胀和脓液排放附近的耳前区域。患者有下颌骨拔牙史,既往有反复肿胀和咬牙。治疗:诊断为慢性化脓性骨髓炎,在全身麻醉下行骨膜切除术。结果:CSO累及髁状突和冠状突是罕见的儿童,使其成为一个独特的情况。应在农村地区更多地鼓励对儿童骨髓炎的认识,以便尽早诊断和及时治疗。
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引用次数: 0
The Innovative Use of the Leyla Retractor in Orbital Floor Reconstruction: Frugal Innovation Reimagined! Leyla牵开器在轨道地板重建中的创新应用:重新想象的节俭创新!
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1007/s12663-025-02741-8
Yash Merchant, Narendra Motarwar

Background: Orbital contents need to be retracted delicately and effectively during complex orbital floor repairs.

Innovation: We employed gentle retraction of orbital contents during a complex floor repair with the LeylaTM retractor used to retract brain parenchyma in neurosurgery. This autoclavable retractor is self-retaining and consists of two flexible tension arms as well as a fixation base and spatula supports. This is available in the neurosurgery sets of most Level I Trauma Centres.

Advantage: The advantage of this technique is that it facilitates gentle and controlled retraction of the orbital contents without requiring assistance. The exposure till the posterior floor of the orbit is excellent and enables a precise and thorough assessment of the defect without being concerned about damaging orbital contents. Since it is self-retaining, the retractor remains in place till the end of reconstruction enabling visualisation with conservative incisions. The design of the flexible arms allows for retraction from multiple angles, crucial for navigating complex orbital floor repair. The smooth edges and precision design of the spatula minimize tissue damage during retraction.

背景:在复杂的眶底修复中,眶内内容物需要精细有效的缩回。创新:我们在复杂的地板修复中使用LeylaTM牵开器进行眶内容物的温和牵开,该牵开器用于神经外科中脑实质的牵开。这种可高压灭菌的牵开器是自保持的,由两个灵活的张力臂以及固定底座和抹刀支撑组成。这在大多数一级创伤中心的神经外科中都是可用的。优点:这种技术的优点是,它有利于温和和控制的眶内容物的收缩,而不需要帮助。曝光至眶后底是极好的,可以在不担心损伤眶内容物的情况下对缺损进行精确和彻底的评估。由于它是自固定的,牵开器保持在原位,直到重建结束,使保守切口可见。柔性臂的设计允许从多个角度收缩,这对于导航复杂的眶底修复至关重要。平滑的边缘和精密设计的刮刀,尽量减少组织损伤在缩回。
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引用次数: 0
Comparing One-Stage Versus Two-Stage Ridge Splitting Procedures: A Systematic Review and Meta-Analysis. 一期和两期脊裂手术的比较:系统回顾和荟萃分析。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2024-06-18 DOI: 10.1007/s12663-024-02240-2
Zainab Khanum, E S Shobha, Neha Nainoor, Nithin Shaju

Aim: To determine, summarize, assess and compare one-stage with two-stage ridge split procedures by systematically reviewing the existing scientific literature in adults with a novel meta-analysis.

Methods: This review was performed in accordance with Preferred Reporting Items for the Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The PubMed, Google Scholar and EBSCO Host databases were searched from January 2000 to December 2021 for prospective and follow-up studies that compared one-stage and two-stage ridge split procedures and reported the outcome in terms of mean and standard deviation (SD). Quality assessment of included studies was done using Newcastle Ottawa Scale through its domains and that of included case reports was done using the critical checklist recommended by the Joanna Briggs Institute (JBI). The standardized mean difference (SDM) was used as summary statistic measure with random effect model and p value < 0.05 as statistically significant.

Results: Eleven studies fulfilling the eligibility criteria were included in qualitative synthesis, of which, three studies were suitable for meta-analysis. All the included studies had moderate to high risk of bias. The pooled estimate through the Standardized Mean Difference (SMD) on an average favours 0.89 times more to one-stage ridge split compared to two-stage ridge split. In addition, most results of heterogeneity tests were poor and most of the funnel plots showed asymmetry, indicating presence of possible publication bias.

Conclusion: The results of our meta-analysis suggests that one-stage ridge split is superior to two-stage ridge split on a comparative analysis.

目的:通过一项新的荟萃分析系统地回顾现有的成人科学文献,确定、总结、评估和比较一期和两期脊裂手术。方法:本综述按照系统评价和荟萃分析(PRISMA)指南的首选报告项目进行。从2000年1月至2021年12月,检索PubMed、谷歌Scholar和EBSCO Host数据库,以比较一期和两期脊裂手术的前瞻性和随访研究,并以均值和标准差(SD)报告结果。纳入研究的质量评估使用纽卡斯尔渥太华量表通过其域完成,纳入病例报告的质量评估使用乔安娜布里格斯研究所(JBI)推荐的关键检查表完成。采用标准化平均差(SDM)作为汇总统计量,采用随机效应模型和p值。结果:定性综合纳入11项符合合格标准的研究,其中3项研究适合进行meta分析。所有纳入的研究都有中度到高度的偏倚风险。通过标准化平均差(SMD)的汇总估计,与两段脊裂相比,一期脊裂的平均优势为0.89倍。此外,大多数异质性检验结果较差,大多数漏斗图显示不对称,表明可能存在发表偏倚。结论:我们的荟萃分析结果表明,一期脊裂优于两期脊裂的比较分析。
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引用次数: 0
Comparative Evaluation of Stability of Rigid and Non-Rigid Fixation in Bifocal Fractures of Mandible Involving a Unilateral Mandibular Subcondyle Fracture Associated with a Contralateral Mandibular Dentate Fracture: A Finite Element Analysis. 单侧下颌髁下骨折合并对侧下颌齿状骨折的双焦点骨折刚性与非刚性固定稳定性的比较分析:有限元分析。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-10-14 DOI: 10.1007/s12663-025-02744-5
Aditya Dinesh Dhirawani, Sunil Sidana, Srivalli Natarajan, Richa Agrawal

Introduction: Fixation of bifocal fractures of the mandible remains an enigma for surgeons as to how much fixation would be able to provide adequate stability. Increasing number of miniplates could lead to more complications. Thus, the aim of the study was to evaluate to minimum amount of fixation required to achieve adequate stability in bifocal fracturees of the mandible.

Materials and methods: The study was carried out in the Department of Oral & Maxillofacial Surgery and the Department of Mechanical Engineering using a finite element analysis. The Von Mises stresses and deformation distribution was analyzed when the mandibular subcondylar fracture and the contralateral parasymphysis or body fracture was fixed using a single or two miniplates. Forces were applied on the incisors, left and right molars.

Results: The results revealed that the mandibular parasymphysis or body fracture with a contralateral mandibular subcondyle fracture showed adequate stability when fixed using a single four-hole with gap titanium miniplate for fixation of both fractures in combination with an arch bar (Von Mises stress on mandible = 555.59 MPa, 558.62 MPa on 150 N incisor load; 545.98 MPa, 545.24 MPa on 300 N left molar load; and 612.99 MPa, 652.85 MPa on 300 N right molar load).

Conclusion: Non-rigid fixation is sufficient to provide adequate stability for bifocal fractures of the mandible involving unilateral mandibular subcondyle with associated contralateral mandibular dentate fracture.

下颌骨双焦点骨折的固定对于外科医生来说仍然是一个谜,即固定多少才能提供足够的稳定性。越来越多的微型钢板可能导致更多的并发症。因此,本研究的目的是评估在下颌双焦点骨折中达到足够稳定性所需的最小固定量。材料与方法:本研究在口腔颌面外科和机械工程系采用有限元分析方法进行。分析下颌髁下骨折和对侧副骨或体骨折用单个或两个微型钢板固定时的Von Mises应力和变形分布。用力作用于门牙、左右磨牙。结果:下颌副骨或体骨折伴对侧髁下骨折,采用单颗四孔带间隙微型钛板联合弓棒固定时,下颌Von Mises应力分别为:150 N切牙载荷下555.59 MPa、558.62 MPa; 300 N左磨牙载荷下545.98 MPa、545.24 MPa; 300 N右磨牙载荷下612.99 MPa、652.85 MPa。结论:非刚性固定足以为单侧下颌髁下骨折伴对侧下颌齿状骨折的双焦点骨折提供足够的稳定性。
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引用次数: 0
Unraveling Odontogenic Infections: Insights from 278 Patients in an Indian Tertiary Care Setting. 揭露牙源性感染:来自278名印度三级医疗机构患者的见解。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1007/s12663-025-02770-3
Chandrashekhar Chattopadhyay, Vikas Deo, Charu Chouhan, Mamta Patel, Ayush Garg, Priti Airun

Background: Odontogenic infections (OIs) pose a significant public health burden in low- and middle-income countries (LMICs) due to socioeconomic barriers and limited dental care access. This study characterizes OIs in an Indian tertiary care setting, evaluating clinical features, management, and outcomes.

Methods: A retrospective cohort study of 278 patients with OIs (July 2022-July 2025) was conducted at a government tertiary care center in Western India. Data on demographics, clinical characteristics, comorbidities (e.g., diabetes mellitus [DM], malnutrition), risk factors (e.g., smoking, gutka chewing), diagnostics, management (e.g., incision and drainage [I&D], antibiotics), and outcomes were analyzed using chisquare tests, logistic regression, and Kaplan-Meier survival analysis.

Results: Periapical abscesses (45.0%) and Ludwig's angina (18.0%) were predominant, driven by poor oral hygiene (70.1%), smoking (39.9%), and uncontrolled DM (34.9%). Aggressive I&D (71.9%), modified incisions for Ludwig's angina, and antibiotic sensitivity testing (ABST)-guided therapy (25.2%) achieved a 99.3% resolution rate. Complications (15.1%) included osteomyelitis (6.1%) and sepsis (6.1%), with a 0.7% mortality rate. DM (OR 3.5, 95% CI 2.0-6.1) and smoking (OR 2.8, 95% CI 1.5-4.9) predicted complications.

Conclusions: OIs in LMICs are exacerbated by socioeconomic and clinical factors. Costeffective interventions (e.g., sanitary pads, suction drains) and early management improve outcomes. Recommendations include enhanced oral health education, diagnostic access, and antibiotic stewardship.

背景:由于社会经济障碍和有限的牙科保健机会,牙源性感染(OIs)在低收入和中等收入国家(LMICs)构成了重大的公共卫生负担。本研究描述了印度三级医疗机构的OIs特征,评估了临床特征、管理和结果。方法:在印度西部的一家政府三级保健中心对278例OIs患者(2022年7月至2025年7月)进行回顾性队列研究。人口统计学、临床特征、合并症(如糖尿病、营养不良)、危险因素(如吸烟、嚼口香糖)、诊断、治疗(如切口引流、抗生素)和结局等数据采用chisquare检验、logistic回归和Kaplan-Meier生存分析进行分析。结果:以根尖周脓肿(45.0%)和路德维希心绞痛(18.0%)为主,口腔卫生不良(70.1%)、吸烟(39.9%)和非控制型糖尿病(34.9%)是主要病因。积极I&D(71.9%)、改良切口治疗路德维希心绞痛(Ludwig’s心绞痛)和抗生素敏感性试验(ABST)引导治疗(25.2%)的治愈率达到99.3%。并发症(15.1%)包括骨髓炎(6.1%)和败血症(6.1%),死亡率为0.7%。糖尿病(OR 3.5, 95% CI 2.0-6.1)和吸烟(OR 2.8, 95% CI 1.5-4.9)预测并发症。结论:社会经济和临床因素加重了低收入国家的oi。具有成本效益的干预措施(如卫生巾、吸力排水管)和早期管理可改善结果。建议包括加强口腔健康教育、获得诊断和抗生素管理。
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引用次数: 0
Fabrication of a Provisional and Immediate Nasal Prosthesis Following Rhinectomy: Case Report of a Protocol. 鼻切除术后临时和即时鼻假体的制作:一个方案的病例报告。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-09-26 DOI: 10.1007/s12663-025-02738-3
Aishwarya Chatterjee, Kamal Kishor Lakhera, Suresh Singh, Pinakin Patel, Agil Babu, Bhoopendra Singh Gora, Naina Kumar

Background: Patients undergoing rhinectomy often experience significant functional and psychological distress due to facial disfigurement. An immediate provisional nasal prosthesis can provide aesthetic restoration during the healing period before definitive reconstruction or prosthesis fabrication.

Materials and methods: A presurgical facial impression was obtained prior to rhinectomy. Necessary trimming of the nasal profile was carried out on the facial moulage. A wax sculpture replicating the desired nasal form and profile was created on the model. This wax sculpture was duplicated using an elastomeric impression material to prepare a master cast, from which a vacuum-formed provisional nasal prosthesis was fabricated. The prosthesis was placed intraoperatively and secured to the surrounding skin using stay sutures. A second mold of the wax sculpture was prepared for fabrication of a definitive interim prosthesis. Preoperative skin color matching was performed, and medical-grade room temperature vulcanizing (RTV) silicone was processed using this mold.

Results: The initial vacuum-formed prosthesis was worn by the patient for 72-h postoperatively. After this period, a silicone interim nasal prosthesis was delivered, which could be worn daily and retained using adhesive tapes. This approach provided an immediate cosmetic solution and allowed for easy remaking of the prosthesis during the healing phase.

Conclusion: The described protocol enables the fabrication of an immediate provisional nasal prosthesis using preoperative facial impressions. This method offers psychological support, facilitates social reintegration, and improves the patient's quality of life during the postoperative healing period following rhinectomy.

背景:由于面部畸形,接受鼻切除术的患者经常经历显著的功能和心理困扰。在最终重建或假体制作之前,立即使用临时鼻假体可以在愈合期间提供美学修复。材料和方法:在鼻切除术前获得术前面部印模。对面部模印进行必要的鼻部轮廓修剪。在模型上创建了一个复制所需鼻部形状和轮廓的蜡雕。这个蜡像是用弹性体压模材料复制的,准备了一个主铸件,从中制造了一个真空形成的临时鼻假体。术中放置假体并使用停留缝线将其固定在周围皮肤上。蜡像的第二个模具准备制造一个最终的临时假体。术前进行皮肤颜色匹配,并使用该模具加工医用级室温硫化(RTV)硅胶。结果:患者术后72小时佩戴初始真空形成的假体。在此期间,硅胶临时鼻假体被交付,可以每天佩戴并使用胶带保留。这种方法提供了一种即时的美容解决方案,并允许在愈合阶段轻松重建假体。结论:所描述的方案能够使用术前面部印模制造即时临时鼻假体。这种方法提供心理支持,促进社会重新融入,并提高患者在鼻切除术后术后愈合期间的生活质量。
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引用次数: 0
Does ORIF Yield Favourable Outcomes in Condylar Head Fractures? A Prospective Analysis of 76 Cases. ORIF治疗髁突头骨折疗效好吗?76例前瞻性分析。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-04-10 DOI: 10.1007/s12663-025-02529-w
Sonal Anchlia, Jigar Dhuvad, Ghanshyam Prajapati, Shruti Morzaria, Ankita Sahal, Monika Chudasama

Background: Mandibular condylar fractures, particularly condylar head fractures (CHFs), pose significant challenges due to their location within the temporomandibular joint (TMJ). The optimal management of CHFs remains controversial, with various treatment modalities available.

Aim: To evaluate the efficacy of open reduction and internal fixation (ORIF) for CHFs using an inviscision approach and fixation with one bicortical screw, two bicortical screws, and miniplates to assess post-operative outcomes and complications.

Materials and methods: According to He et al., Type A, B 67 cases (76 joints) of condylar head fractures were treated for ORIF. The parameters like exposure and fixation times, types of fixations, disc repositioning/repair, mouth opening, bite force, occlusion, excursive movements, chin deviation, pain, fracture reduction and complications were monitored. Patient satisfaction score and scar formation were also evaluated.

Results: Road traffic accidents were the primary cause of CHFs (46.27%). Average surgical exposure time was 13.12 min. Post-operative outcomes demonstrated significant improvements in mouth opening, bite force, and occlusal derangement. Radiographic evaluation revealed successful anatomical reduction in 76.32% of cases, with minimal complications like post-operative infection (9.21%) and transient facial nerve injury (22.37%). Overall, patient satisfaction score was 4 and the average score of 2 on Patient and Observer Scar Assessment Scale. Top of FormTop of Form.

Conclusion: A comprehensive approach incorporating aesthetic surgical techniques, precise fracture management, and disc repositioning is crucial for successful management of CHFs. ORIF using inviscision techniques, long bicortical screws, and miniplates presents a promising treatment modality for restoring TMJ function and achieving high patient satisfaction rates.

背景:下颌骨髁突骨折,特别是髁突头骨折(CHFs),由于其位于颞下颌关节(TMJ)内,构成了重大挑战。CHFs的最佳管理仍然存在争议,有各种治疗方式可用。目的:评价切开复位内固定(ORIF)治疗CHFs的疗效,采用一枚双皮质螺钉、两枚双皮质螺钉和微型钢板固定CHFs,评估术后疗效和并发症。材料与方法:He等对A、B型髁突头骨折67例(76个关节)进行ORIF治疗。监测暴露和固定时间、固定物类型、椎间盘复位/修复、开口、咬合力、咬合、游离运动、下颌偏移、疼痛、骨折复位及并发症等参数。患者满意度评分和疤痕形成也进行了评估。结果:道路交通事故是导致CHFs的主要原因(46.27%)。平均手术暴露时间为13.12 min。术后结果显示口腔开口、咬合力和咬合紊乱有显著改善。x线评估显示76.32%的病例解剖复位成功,术后感染(9.21%)和一过性面神经损伤(22.37%)等并发症极少。总体而言,患者满意度得分为4分,患者和观察者疤痕评估量表平均得分为2分。FormTop of Form。结论:综合美学手术技术、精确骨折处理和椎间盘复位是成功治疗CHFs的关键。使用无粘连技术、长双皮质螺钉和微型钢板的ORIF是恢复TMJ功能和获得高患者满意度的有前途的治疗方式。
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引用次数: 0
A Prospective Observational Study to Assess the Incidence of Preoperative Distress Levels and its Impact on Postoperative Complications in Patients with Oral Squamous Cell Carcinoma. 一项评估口腔鳞状细胞癌患者术前焦虑水平发生率及其对术后并发症影响的前瞻性观察研究。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-04-25 DOI: 10.1007/s12663-025-02461-z
Shivakumar Thiagarajan, Trupti Sable, Rukmini Prabhu, Jayita Deodhar, Savita Goswami

Background: Distress is a multifactorial emotional experience which many cancer patients experience. Increased distress levels, as measured by the NCCN distress thermometer, are associated with poor treatment compliance and reduced survival. It has also been shown to be associated with poor wound healing.

Methodology: This prospective observational was done to assess the incidence of preoperative distress levels in head and neck squamous cell carcinoma patients and its impact on postoperative complications.

Results: A total of 350 patients were enrolled in the study. The majority of the patients had oral squamous cell carcinoma (n = 333, 95.1%). The incidence of postoperative complications was 14.3% (n = 50/350). The incidence of preoperative distress levels of ≥ 4 was only 5.14% (n = 18/350), and it did not have any influence on the postoperative complications. The factors that predisposed to the development of postoperative complications were the need for tracheostomy (p < 0.001 [5.844(3.060 - 11.160)]), duration of surgery > 4 h (p = 0.012 [3.753(1.833 - 4.807)]), and patient belonging to the lower socioeconomic strata (p = 0.003[2.711(1.407 - 5.224)]).

Conclusions: The incidence of significant preoperative distress levels was low in our cohort, and it did not influence the development of postoperative complications. The findings from this study may well need further confirmation. The low distress scores reported in our study should not deter from routinely checking for preoperative distress levels in head and neck cancer patients.

背景:痛苦是许多癌症患者所经历的多因素情感体验。由NCCN痛苦温度计测量的痛苦程度增加与治疗依从性差和生存率降低有关。它也被证明与伤口愈合不良有关。方法:本前瞻性观察旨在评估头颈部鳞状细胞癌患者术前焦虑水平的发生率及其对术后并发症的影响。结果:共有350例患者入组研究。以口腔鳞状细胞癌为主(n = 333, 95.1%)。术后并发症发生率为14.3% (n = 50/350)。术前窘迫程度≥4的发生率仅为5.14% (n = 18/350),且对术后并发症无影响。术后并发症发生的易发因素为是否需要气管造口(p = 0.012[3.753(1.833 ~ 4.807)])和患者所属社会经济阶层较低(p = 0.003[2.711(1.407 ~ 5.224)])。结论:在我们的队列中,术前显著焦虑水平的发生率较低,且不影响术后并发症的发生。这项研究的结果可能需要进一步的证实。在我们的研究中报告的低焦虑评分不应该阻止常规检查头颈癌患者的术前焦虑水平。
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引用次数: 0
A Systematic Review on Prior/Postoperative Antibiotics Therapy Efficiency in Reducing Surgical Complications After Third Molar Extraction Surgery. 减少第三磨牙拔牙术后并发症的术前/术后抗生素治疗效果的系统评价。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2024-11-22 DOI: 10.1007/s12663-024-02355-6
Shahrokh Raiesian, Amir Danial Pour Ahmadiyeh, Mahdis Masoud Rad

Background: One of the most common dental surgeries is third molar extraction which often leads to pain and swelling after surgery. In recent years, the prophylactic antibiotics before or after surgeries have been used to reduce the risk of injuries and infection. Various researches conducted in this field have yielded contradictory results. The aim of prophylactic antibiotic treatment is to prevent possible infections and complications after surgery, while antibiotic prescription after surgeries reduces clinical symptoms such as pain. The aim of the present review study is to determine and compare the effect of antibiotic drugs before and after third molar extraction in order to reducing surgical complications.

Material and methods: The research was conducted using electronic databases provided by PubMed, Scopus, Web of Science and Google Scholar, with applying inclusion and exclusion criteria. Accordingly, all the clinical trials published since 2000 focused on the antibiotic treatments in third molar extraction surgery were included in this review.

Results: The obtained results from 18 selected studies demonstrated that there is no statistically significant document to confirm the efficacy of antibiotics to prevent post-surgery complications such as swelling and pain after third molar extraction.

Conclusion: Dentists should carefully consider the potential increase in bacteria's resistance to antibiotics and the possibility of side effects when prescribing them. This is because in some cases, the disadvantages may outweigh the benefits for the patient.

背景:第三磨牙拔牙是最常见的牙科手术之一,术后经常出现疼痛和肿胀。近年来,手术前后预防性使用抗生素已成为降低手术损伤和感染风险的重要手段。在这一领域进行的各种研究得出了相互矛盾的结果。预防性抗生素治疗的目的是预防手术后可能出现的感染和并发症,而手术后的抗生素处方可以减轻疼痛等临床症状。本综述的目的是确定和比较第三磨牙拔除前后抗生素药物的效果,以减少手术并发症。材料和方法:本研究采用PubMed、Scopus、Web of Science和谷歌Scholar提供的电子数据库,采用纳入和排除标准。因此,本综述纳入了自2000年以来发表的所有关于第三磨牙拔牙手术中抗生素治疗的临床试验。结果:选取18项研究得出的结果表明,没有统计学意义的文献证实抗生素对预防第三磨牙拔牙术后肿胀、疼痛等并发症的有效性。结论:牙医在开处方时应慎重考虑细菌对抗生素的耐药性可能增加及可能产生的副作用。这是因为在某些情况下,对病人来说,弊大于利。
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引用次数: 0
Chronic Viral Infections and Development of Vascular Malformations/Tumors of Head and Neck: Is There a Correlation? 慢性病毒感染与头颈部血管畸形/肿瘤的发展:是否存在相关性?
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-10-01 Epub Date: 2025-05-15 DOI: 10.1007/s12663-025-02562-9
Stefania Troise, Federica Calabria, Giulia Togo, Andrea Bagnato, Rosa Maria Di Crescenzo, Vincenzo Abbate, Giovanni Dell'Aversana Orabona

Background: Angiogenesis is the process of new vessels formation. Vascular endothelial growth factor (VEGF) is the most involved growth factor in endothelial cell proliferation. Many viruses are implicated in this process, directly through membrane receptors or indirectly by stimulating VEGF production. In particular, hepatitis B virus (HBV) can stimulate proliferation of endothelial cells, contributing to the development of vascular malformations and tumors, benign as hemangiomas or malignant as hepatocarcinoma or cholangiocarcinoma.

Objective: Starting from these assumptions, the authors of this observation paper questioned the possibility that chronic HBV infection could determine vascular malformations/tumors also in other areas, in particular head and neck.

Case description: To answer this question, a case of a 52-year-old woman with chronic HBV infection, who developed a vascular malformation of the upper lip, was described.

Conclusion: This hypothesis of correlation between chronic viral infections, with a blood viral load 0, and vascular malformations/tumors can lay the foundations for carrying out molecular studies.

背景:血管生成是新血管形成的过程。血管内皮生长因子(Vascular endothelial growth factor, VEGF)是参与内皮细胞增殖最重要的生长因子。许多病毒直接通过膜受体或通过刺激VEGF产生间接参与这一过程。特别是,乙型肝炎病毒(HBV)可以刺激内皮细胞的增殖,促进血管畸形和肿瘤的发展,良性如血管瘤,恶性如肝癌或胆管癌。目的:从这些假设出发,这篇观察论文的作者质疑慢性HBV感染是否也可能决定其他部位的血管畸形/肿瘤,特别是头颈部。病例描述:为了回答这个问题,我们描述了一名52岁的慢性HBV感染女性,她出现了上唇血管畸形。结论:血液病毒载量为0的慢性病毒感染与血管畸形/肿瘤相关的假设为开展分子研究奠定了基础。
{"title":"Chronic Viral Infections and Development of Vascular Malformations/Tumors of Head and Neck: Is There a Correlation?","authors":"Stefania Troise, Federica Calabria, Giulia Togo, Andrea Bagnato, Rosa Maria Di Crescenzo, Vincenzo Abbate, Giovanni Dell'Aversana Orabona","doi":"10.1007/s12663-025-02562-9","DOIUrl":"https://doi.org/10.1007/s12663-025-02562-9","url":null,"abstract":"<p><strong>Background: </strong>Angiogenesis is the process of new vessels formation. Vascular endothelial growth factor (VEGF) is the most involved growth factor in endothelial cell proliferation. Many viruses are implicated in this process, directly through membrane receptors or indirectly by stimulating VEGF production. In particular, hepatitis B virus (HBV) can stimulate proliferation of endothelial cells, contributing to the development of vascular malformations and tumors, benign as hemangiomas or malignant as hepatocarcinoma or cholangiocarcinoma.</p><p><strong>Objective: </strong>Starting from these assumptions, the authors of this observation paper questioned the possibility that chronic HBV infection could determine vascular malformations/tumors also in other areas, in particular head and neck.</p><p><strong>Case description: </strong>To answer this question, a case of a 52-year-old woman with chronic HBV infection, who developed a vascular malformation of the upper lip, was described.</p><p><strong>Conclusion: </strong>This hypothesis of correlation between chronic viral infections, with a blood viral load 0, and vascular malformations/tumors can lay the foundations for carrying out molecular studies.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 5","pages":"1386-1389"},"PeriodicalIF":0.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of Maxillofacial & Oral Surgery
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