Izvestiâ Saratovskogo universiteta. Novaâ seriâ最新文献

{"title":"Composite hydrogel gellan gum-based materials with CaCO3 vaterite particles","authors":"M. S. Saveleva, P. A. Demina","doi":"10.18500/1817-3020-2023-23-3-245-253","DOIUrl":"https://doi.org/10.18500/1817-3020-2023-23-3-245-253","url":null,"abstract":". Background and Objectives : Hydrogels are cross-linked three-dimensional polymeric structures containing a large amount of water. Hydrogel materials based on natural and/or synthetic biocompatible polymers are capable of imitating the structure and properties of the extracellular matrix of living tissues. Therefore, hydrogel-based materials are widely studied and developed as functional materials in various fields of biology and medicine, including the creation of biomaterials for transplantation and tissue engineering. However, hydrogels have a number of disadvantages, such as a low biomineralization capacity, low biomechanical properties, and weak ability to form biointerface with hardtissues.Thesepropertiesmakehydrogel-basedmaterialsunsuitableforhardtissueengineering,particularly,boneregeneration.Currently, approaches to overcome these limitations, in particular, to improve the biological activity and biomineralization of hydrogels are currently being widelydeveloped. MaterialsandMethods : Thisstudyreportsanefficientapproachofhydrogelsmineralizationbasedontheultrasound-assisted synthesis of calcium carbonate CaCO 3 in the gellan gum hydrogel material. Results : The composite hydrogel materials based on the gellan gum with CaCO 3 micron-sized particles in the vaterite polymorph, uniformly distributed within the hydrogel matrix, have been obtained. The fraction of CaCO 3 in the hydrogel can easily be controlled by the number of ultrasound treatment procedures. The morphology and structure of the obtained hydrogel materials, especially the structure and distribution of the inorganic phase CaCO 3 , have been studied by scanning electron microscopy and X-ray diffraction. Conclusion : The proposed strategy for the hydrogel mineralization allows for to create functional composite materials with the potential for application for the tissue engineering, especially bone regeneration.","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of the biological and functional properties of microorganisms with high resistance to manganese (II)","authors":"Milena A. Kasatkina, Maxim V. Reshetnikov, Ekaterina V. Pleshakova","doi":"10.18500/1816-9775-2023-23-3-318-330","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-3-318-330","url":null,"abstract":"The issue of water treatment of the central water supply, as well as wastewater, from excessive content of heavy metals (HMs) remains relevant at the present time. The presence of heavy metals, even in trace amounts, has a negative impact not only on the environment, but also on all human organic systems. At the moment, iron and manganese are among the main pollutants entering the human body via drinking water. Studies were carried out on the biological and functional properties of microorganisms isolated from highly magnetic soil, which previously demonstrated high resistance to manganese (II). Microbial strains with maximum resistance to Mn (II) were identified as: Bacillus simplex 55.2, B. simplex 13.2 and Listeria murrayi 13.4. The growth dynamics of B. simplex 55.2 and B. megaterium 69.5 was studied under conditions of periodic cultivation in a liquid medium containing 2 mmol/L Mn (II). It was shown that after 7 day’s cultivation, the weight of the biomass of B. megaterium 69.5 increased by 5.5 times, B. simplex 55.2 increased by 3.7 times relative to the values after 1 day cultivation, the optical density of the culture medium B. megaterium 69.5 increased 4 times, B. simplex 55.2 increased 2 times compared with the initial sowing dose. The specific growth rate of B. megaterium 69.5 after 7 days cultivation was higher than that of B. simplex 55.2 by about 2 times, and the degree of removal of Mn (II) from the aquatic environment was less. B. simplex 55.2 reduced the content of Mn (II) by 66%, B. megaterium 69.5 reduced by 50%. It was established that B. megaterium 69.5, B. simplex 55.2, B. simplex 13.2 and L. murrayi 13.4 are able to grow in conditions of high alkalinity and mineralization of the medium (pH 7–10; 10% NaCl). Taking into account that these microorganisms are able to remove high concentrations of Mn (II) from the aquatic environment, they are promising for their use in water treatment biotechnology.","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"28 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone use in solid-phase fluorimetric determination of some polypeptide antibiotics in medicinal preparations","authors":"Dmitry S. Bolshakov, Zen Аlabden Chalawi Shogah, Vasily G. Amelin","doi":"10.18500/1816-9775-2023-23-3-252-261","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-3-252-261","url":null,"abstract":"The analysis of semi-products at different stages of production and finished medicinal products is an integral part of an effective quality assurance system for pharmaceutical production. The traditional methods used in the pharmaceutical field, such as capillary electrophoresis, gas and liquid chromatography, are quite versatile and effective. However, they are distinguished by the high cost of instrumentation and component materials, the need to use high-purity solvents, the lack of mobility and the possibility of in situ studies. Such shortcomings can be overcome by using the digital colorimetry method. Its significant popularization has been facilitated by the development of portable and personal electronic devices, among which the smartphone can be distinguished. The aim of the work was to develop a fast and simple method for the determination of a number of polypeptide antibiotics in drugs by digital colorimetry using a smartphone as a color recording device. To implement the solid phase fluorimetric determination of polypeptide antibiotics, HPTLC plates based on silica gel with an aluminum substrate were used as a matrix. Under these conditions, the fluorescence of actinomycin D, virginiamycin M1, virginiamycin S1, and novobiocin was observed when exposed to monochromatic radiation in the UV part of the spectrum (365 nm). The measurement of fluorescence intensity on the surface of the matrices was carried out using a smartphone. Calibration characteristics were constructed for the determination of polypeptide antibiotics in the concentration range of 32–500 μg/mL. The method for assessing the quality of finished drugs was tested on commercial products “Piostacin”, “Cosmegen”, “Dactinomycin” purchased in retail chains. The relative standard deviation of the analysis results does not exceed 0.05. The duration of the analysis was 10–15 min. Based on the results of the studies, the paper presents a method for determining some antibiotics of the polypeptide series by the intrinsic fluorescence of deposited solutions on a solid substrate during treatment with monochromatic UV radiation. The experimental delivery conditions used allow the analysis of drugs based on actinomycin D, virginiamycin M1, virginiamycin S1, and novobiocin.","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformations of substituted cyanoiminooctahydroquinazolines under oxidation conditions","authors":"Daniil A. Puzanov, Anna E. Sklyar, Marina V. Konenkova, Adel P. Krivenko","doi":"10.18500/1816-9775-2023-23-3-299-307","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-3-299-307","url":null,"abstract":"Substituted quinazolines of various degrees of saturation and functionalization possess a wide spectrum of biological activity, in particular, anticancer activity, which predetermines the importance of obtaining new representatives of this type of compounds and studying their practically useful properties. Methods for the preparation of 2-cyanoiminoquinazolines are poorly described in the literature, while their properties and oxidation reactions have not been studied at all. We have analyzed the stability of tautomeric forms of 2-cyanoiminoquinazolines, determined the activation energy of their formation using quantum-chemical calculations, studied their transformation under the action of strong oxidants (CrO3/AcOH, NaNO2/AcOH). Selective aromatization of the azoheterocycle and hydrolysis of the -CN-group to form 2-aminocarbamoylquinazoline occurred during oxidation. An increase in temperature from 120 to 160° C (using CrO3) resulted in the formation of 2-nitrosoquinazoline. The structure of our new obtained substances was established by spectral methods (IR, 1H, 13C NMR, HSQC, NOESY), a scheme of their formation has been proposed.","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual psychological indicators of a person’s addiction to social networks: An integrative approach","authors":"Tatyana V. Belykh","doi":"10.18500/2304-9790-2023-12-3-227-235","DOIUrl":"https://doi.org/10.18500/2304-9790-2023-12-3-227-235","url":null,"abstract":"The relevance of the study is due to the following fact. Comparative analysis of individual psychological characteristics of students with and without addiction to social networks, that is conducted by means of the integrative approach, allows us, firstly, to identify the connection of multi-level characteristics in the structure of the individuality and, secondly, to single out latent, resource capabilities of the individual for psycho-prophylaxis and psycho-correction of this addiction. The research objective is to study individual psychological characteristics of the students who are either addicted to social networks or do not have such an addiction. The objective is achieved by using the integrative approach. The article hypothesizes that university students with a prominent addiction to social networks have specific features of integration of psychodynamic, personal and socio-psychological traits in the structure of students’ individuality. The study sample includes 154 1st – 3d-year students of Saratov State University, aged 17 to 20, the average age 18.6, SD = 0.61, 45% of young men, 55% of young women. The research methods (tools) are as follows. The questionnaire of formal-dynamic individuality properties (by V. M. Rusalov) was used to identify psychodynamic properties in the structure of one’s individuality. To study personal qualities, the following tools were used: The Freiburg Personality Inventory (the modified form “B”) (developed by A. A. Krylov and T. I. Ronginskaya), The Holmes and Rahe Stress Scale, the Technique for Diagnosing the Level of Neuroticism (by L. I. Wasserman). To identify socio-psychological characteristics the questionnaire “Perception of the Internet” (by E. A. Schepilina) was used; to measure the degree of a person’s addiction to social networks, the “Social Networks Addiction Assessment Questionnaire” (by V. P. Sheinov, A. S. Devitsyn) was used. The research results. The study has revealed significant differences in the integration of multi-level individual psychological qualities in the structure of students’ individuality in the compared samples. The conclusion. Students’ addiction to social networks is manifested by the following symptom complex of characteristics: low psychodynamic resourcefulness in the communicative sphere, high emotionality and its lability, neuroticism, disposition to depressive states and psychological difficulties in interpersonal communication. Independence from the use of social networks is accompanied by motor and communicative endurance at the psychodynamic level of integral individuality, introversion, high speed of intellectual information processing and assimilation of communication skills, as well as sociability at the personal level. The compared sample groups differ in the type of contribution of psychodynamic features to the manifestation of the social networks addiction. This can influence manifestation of sociability during contact interaction and can determine the tend","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal correlates of self-efficacy in educational and professional activities of medical university students","authors":"Victor V. Enin","doi":"10.18500/2304-9790-2023-12-3-236-245","DOIUrl":"https://doi.org/10.18500/2304-9790-2023-12-3-236-245","url":null,"abstract":"The relevance of the study is due to the following fact. The study of the personal determinants of self-efficacy of medical university students is a relevant research issue as it allows us to identify their contribution to the development of an adequate image of the “professional self” in the structure of the self-concept of future doctors. The purpose of the research is to study the correlation between personal characteristics of university students and different degrees of self-efficacy in educational and professional activities. Hypothesis. There are presumably particular differences in the actualization of connections between personal properties of students who show a high and low level of self-efficacy while studying at a medical university. The participants of the study are 3rd and 4th-year students of Stavropol State Medical University (Stavropol) (N = 187, 105 of them are females and 82 of them are males, the average age is 20 years old, SD = 0.78). The research methods (tools) include the Self-Efficacy Questionnaire in the form of a test (by J. Maddux, M. Scheer, adapted by A. V. Boyarintseva) that is aimed at studying the degree of subject-matter and communicative self-efficacy manifestation; the Schwarzer R. & Jerusalem M. Generalized Self-Efficacy Scale that diagnoses the degree of general self-efficacy manifestation; the questionnaire “The Style of Behavior Self-Regulation” (by V. I. Morosanova) that identifies self-regulation styles and manifestation degree of its general level; the Questionnaire on Tolerance-Intolerance to Uncertainty (by T.V. Kornilova) that diagnoses the manifestation degree of general and interpersonal tolerance or intolerance to uncertainty. The study also applies the procedure aimed at measuring the manifestation degree of a person’s self-efficacy in educational and professional activities (based on self-assessment). Results: the study has revealed both similarities and differences in the correlation between personal properties in students with different levels of self-efficacy in educational and professional activities. Main conclusions: the research has revealed the greatest differences in the correlation between the studied personal properties in the compared groups in the following options: between the expression of self-efficacy in educational and professional activities and tolerance/intolerance to uncertainty, and between intolerance to uncertainty and self-regulation styles. The similarities of personal correlates of students with high and low self-efficacy in educational and professional activities are manifested in significant links between the manifestation level of subject-matter self-efficacy and preferred self-regulation styles. The study has found that self-efficacy in educational and professional activities, regardless of its manifestation level, is directly correlated with all measurable types of self-efficacy. The obtained results can be useful in designing developmental psychological and","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The State-Society syncretism in Thomas Hobbes’ theory of social contract","authors":"Ivan S. Golubev","doi":"10.18500/1819-7671-2023-23-3-258-261","DOIUrl":"https://doi.org/10.18500/1819-7671-2023-23-3-258-261","url":null,"abstract":"Introduction. The article analyzes the state-society relationship in the theory of social contract by T. Hobbes. The etatist interpretation of his socio-political doctrine, widespread in Russian philosophical thought, fundamentally opposing society to the state, does not seem to reflect the understanding of their relationship. From our point of view this is inherent in the contractual theory of the English thinker. Theoretical analysis. The author shows that the original conceptual and theoretical principles of T. Hobbes are the unity of sociogenesis and politogenesis, the actual identification of sociality and statehood, and the assertion of the need for security as the most important factor in the transition of people from the «state of nature» to the state-public organization of their life together. Analyzing the nature of state power, T. Hobbes believes that the political activity of the sovereign, as the source and bearer of the first, is subject, first of all, to the interests of the society he controls. Conclusion. The etatist interpretation of the state-society relationship does not find sufficient confirmation in the theory of the social contract of T. Hobbes. The analysis made it possible to reveal that his point of view on this problem can be described with the idea of the syncretism of society and the state, which implies the unity of the processes of sociogenesis and politogenesis and, accordingly, the simultaneous emergence of these forms of common life.","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136101008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pH and ionic strength on the photoluminescence of size-fractionated AgInS2/ZnS quantum dots","authors":"T. S. Ponomaryova, V. V. Olomskaya, A. S. Novikova, I. Yu. Goryacheva","doi":"10.18500/1817-3020-2023-23-3-238-244","DOIUrl":"https://doi.org/10.18500/1817-3020-2023-23-3-238-244","url":null,"abstract":"","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical reactions of 2,4-dinitrophenylhydrazine with some aldehydes in micelles of cationic surfactants","authors":"Tatiana A. Sokolova, Anna A. Burmistrova, Sergey Yu. Doronin","doi":"10.18500/1816-9775-2023-23-3-262-271","DOIUrl":"https://doi.org/10.18500/1816-9775-2023-23-3-262-271","url":null,"abstract":"The analytical effect of micelles of cationic surfactants in the reactions of some aromatic aldehydes (AA) with 2,4-dinitrophenylhydrazine (DNPH) with the formation of the corresponding aci-forms of hydrazones has been established. It has been established that micelles of nonionic and anionic surfactants do not cause analytically significant effects in the system under study. Analytical characteristics of systems DNPH–AA– cationic surfactant (molar absorption coefficients (ε), ranges of determined contents, limits of detection) were determined, using the example of benzaldehyde and its nitro-, sulfo-, chlorine-, dimethylamino- and methoxy derivatives, as well as p-dime thylaminocinnamic aldehyde (DMAC). For the majority of aldehydes ranges of determined contents are in the range from 0,2 to 2,1 μg/ml, ε from 2.10-4 to 1.10-5 L.mol-1.cm-1. The hydrazone formed by DNPH and DMAC was synthesized and identified by elemental analysis and IR spectroscopically. The solubility of the resulting hydrazone in aqueous (pH 13) and micellar (cetylpyridinium chloride, CPC) media was studied. It has been shown that its solubility in CPC micelles increases approximately 60 times, which leads to the stabilization of the studied system DNPH – AA – cationic surfactant in time (its isotropy) and an increase in the sensitivity of the determination of the corresponding aldehyde in the absence of volatile and toxic organic solvents, while the principle “green chemistry” has been implemented. The established effect of cationic surfactants was implemented to develop a method for the non-extraction photometric determination of streptomycin (a broad-spectrum aminoglycoside antibiotic effective against tuberculosis) in pharmaceutical preparations with ranges of determined contents from 2,1 to 87,4 μg/ml. The error of direct photometric determination of streptomycin did not exceed 5–9%.","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The problem of comparative evaluation of paintings created by an artist and generated by a neural network","authors":"Alexander F. Panteleev","doi":"10.18500/1819-7671-2023-23-3-326-330","DOIUrl":"https://doi.org/10.18500/1819-7671-2023-23-3-326-330","url":null,"abstract":"Introduction. The role of art in the life of society is to translate humanitarian values. The creator of a truly imaginative work is able to perceive when interacting with the world and embody in his works what may not be in statistics and will probably be relevant for humanity in the future. Theoretical analysis. According to the available data, the pictures aggregated by the neural network and painted by the artist do not differ in subjects. In this paper, an activity-based approach is implemented to assess the differences of such paintings. It is based on the decision of the test subject of the problem associated with the identification of this difference. The difference lies in the method of “translating” the idea of the painting from a symbolic code into a figurative one, objectifying the artist’s attitude to the world, translating humanitarian values in this way. Empirical analysis. In the course of an empirical study, a pairwise comparison of paintings was carried out, as a criterion, the comparison was proposed based on the possible success of the transfer of the artist’s attitude to the world. Conclusion. It was previously stated that the distinction between paintings written by the artist and those generated by the neural network in the conditions of solving a new task for the subject to identify the success of the transfer is problematic.","PeriodicalId":476403,"journal":{"name":"Izvestiâ Saratovskogo universiteta. Novaâ seriâ","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136101009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}