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The association of eating disorder specific and unspecific symptoms with suicidal ideation in patients with anorexia nervosa 神经性厌食症患者饮食失调特异性和非特异性症状与自杀意念的关系
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100633
Evelina Marie Stender , René Freichel , Arne Doose , Inger Hellerhoff , Clara Marie Breier , Ute Lewitzka , Klara Schacht , Daniel Geisler , Joseph A. King , Veit Rössner , Stefan Ehrlich

Background

Anorexia nervosa is a serious eating disorder with a high mortality rate, ranking among the most lethal mental health conditions. This is not only due to sequelae of cachexia, but also due to suicidality. The present study employs a network analysis approach to determine whether there are unique associations between suicidal ideation and eating disorder-specific symptoms in anorexia nervosa, or if suicidal ideation is more influenced by other symptoms such as those more loosely related to eating disorders or general internalizing symptoms, as well as biological factors. Additionally, we examined the potentially changing impact of symptoms after intensive treatment. Methods: The study involved female patients with anorexia nervosa admitted to intensive inpatient treatment. Eating disorder-specific and -related symptoms, depressive, anxiety, obsessive-compulsive symptoms, nutritional data as well as suicidal ideation were assessed at two points: immediately after admission (n = 313) and following partial weight gain (n = 217) and were examined together in a network analysis model. Results: The nodes that were most strongly related to suicidal ideation at both timepoints were feelings of ineffectiveness, as well as depressive and anxiety symptoms. Eating disorder-specific symptoms were found to be not significantly related to suicidal ideation. Conclusions: The results indicate that suicidal ideation in anorexia nervosa is primarily related to broader psychological symptoms rather than eating disorder-specific symptoms. The prominence of feelings of ineffectiveness within the network highlights the need for clinical interventions that focus on the enhancement of self-efficacy in anorexia nervosa.
神经性厌食症是一种严重的饮食失调,死亡率很高,是最致命的心理健康状况之一。这不仅是由于恶病质的后遗症,也是由于自杀。本研究采用网络分析方法来确定自杀意念与神经性厌食症中饮食失调特异性症状之间是否存在独特的联系,或者自杀意念是否更多地受到其他症状的影响,如与饮食失调或一般内化症状更松散相关的症状,以及生物因素。此外,我们检查了强化治疗后症状的潜在变化影响。方法:对住院治疗的女性神经性厌食症患者进行研究。在入院后(n = 313)和部分体重增加后(n = 217)两个时间点评估饮食失调特异性和相关症状、抑郁、焦虑、强迫症状、营养数据以及自杀念头,并在网络分析模型中一起进行检查。结果:在两个时间点与自杀意念最密切相关的节点是无效感,以及抑郁和焦虑症状。饮食失调特有症状与自杀意念无显著关系。结论:神经性厌食症患者的自杀意念主要与更广泛的心理症状有关,而与进食障碍特异性症状无关。网络中无效感的突出强调了临床干预的必要性,重点是提高神经性厌食症的自我效能感。
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引用次数: 0
Rethinking the effects of working memory training on executive functions in schizophrenia: A machine learning approach 重新思考工作记忆训练对精神分裂症患者执行功能的影响:一种机器学习方法
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100628
Tongyi Zhang , Meifang Su , Xiaoning Huo , Xin Zhao

Background

Executive dysfunction in schizophrenia profoundly impairs functional outcomes and remains insufficiently addressed by standard pharmacological treatments. While computerized cognitive training offers promise, traditional evaluation methods often fail to capture nuanced improvements along the psychosis-health continuum. This study aims to quantify executive function (EF) profile changes following working memory training and identify robust baseline predictors of treatment response.

Methods

Ninety-four schizophrenia patients were randomized to adaptive N-back training (n = 32), non-adaptive 1-back control (n = 33), or treatment-as-usual (n = 29). EF was assessed across working memory, cognitive flexibility, and inhibitory control domains. A support vector machine classifier, trained on an independent sample (195 patients, 169 controls) and calibrated via Platt scaling, quantified EF profile changes. An exploratory framework based on Granger causality principles identified baseline treatment predictors.

Results

Adaptive training produced significant near-transfer effects on untrained working memory tasks and reduced general psychopathology (pfdr < 0.05), but no far-transfer effects to other EF domains. The probability of neurotypical EF classification increased substantially in the adaptive group (13.21 % to 38.79 %, p < 0.001), correlating with symptom reduction. Working memory maintenance and response inhibition emerged as the most robust baseline predictors of treatment response.

Conclusions

Working memory training induces meaningful shifts in EF profiles in schizophrenia, promoting movement along the psychosis-health continuum toward neurotypical functioning. The classifier-based approach provides a more refined assessment compared to traditional binary measures, while the exploratory framework identifies specific EF domains predicting treatment response with potential causal relevance. These findings warrant validation through larger, multi-center trials with extended follow-up periods.
精神分裂症患者的执行功能障碍严重损害功能预后,标准药物治疗仍未充分解决这一问题。虽然计算机化的认知训练提供了希望,但传统的评估方法往往无法捕捉到精神病-健康连续体中细微的改善。本研究旨在量化工作记忆训练后执行功能(EF)的变化,并确定治疗反应的稳健基线预测因子。方法将94例精神分裂症患者随机分为适应性n- back训练组(n = 32)、非适应性1-back对照组(n = 33)和常规治疗组(n = 29)。EF通过工作记忆、认知灵活性和抑制控制域进行评估。支持向量机分类器在独立样本(195名患者,169名对照)上进行训练,并通过Platt缩放进行校准,量化EF谱变化。基于格兰杰因果关系原则的探索性框架确定了基线治疗预测因子。结果适应性训练对未训练的工作记忆任务产生了显著的近迁移效应,并降低了一般精神病理(pfdr < 0.05),但对其他EF域没有远迁移效应。在适应组中,神经典型EF分类的概率显著增加(13.21%至38.79%,p < 0.001),与症状减轻相关。工作记忆维持和反应抑制是治疗反应最可靠的基线预测因子。结论:工作记忆训练诱导精神分裂症患者EF谱发生有意义的变化,促进精神-健康连续体向神经典型功能的运动。与传统的二元测量相比,基于分类器的方法提供了更精确的评估,而探索性框架则确定了预测治疗反应的特定EF域,并具有潜在的因果关系。这些发现值得通过更大的、多中心的、延长随访期的试验来验证。
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引用次数: 0
Mind nature: a virtual reality nature therapy for reducing anxiety and negative mood in University Students 心灵自然:减少大学生焦虑和负性情绪的虚拟现实自然疗法
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100636
Jingni Ma , Haoke Li , Mengya Zhao , Joanne Williams
The mental health of young adults, particularly university students, has become a global concern. Nature-based interventions have shown promise in alleviating anxiety and negative emotions. This study explored the effectiveness of Virtual Reality (VR)-based nature therapy in reducing anxiety, negative mood, and stress while enhancing mindfulness among university students. A three-armed randomised controlled trial was conducted. Two hundred thirty-six students with anxiety symptoms were randomly assigned to either a VR intervention group, a placebo control group, or an inactive control group after the baseline assessment. We developed a VR intervention system called Mind Nature, featuring nature-based activities such as planting, observing natural environments, rowing across the water, and personal reflection, all accompanied by mindful audio guidance within a fully immersive 360-degree, three-dimensional VR environment. The placebo control group engaged in a VR sports game using a VR headset, while the control group received no intervention. Each session lasted approximately 30 min. Anxiety, mood, stress, mindfulness, and nature-relatedness were measured three times: pre- and post-intervention and at a 2-week follow-up. Results revealed significant group-time interaction effects, with greater reductions in anxiety, negative affect, and stress in the VR intervention group compared to the placebo and control groups. This study highlights the effectiveness of VR-based nature therapy and its potential as an effective and convenient mental health intervention for university students, offering a promising complement to traditional therapeutic approaches.
The study was registered online at the Chinese Clinical Trial Registry (ID: ChiCTR2400089445)
年轻人,尤其是大学生的心理健康已经成为全球关注的问题。基于自然的干预措施在缓解焦虑和负面情绪方面显示出了希望。本研究探讨了基于虚拟现实(VR)的自然疗法在减轻大学生焦虑、负面情绪和压力的同时增强正念的有效性。进行了一项三臂随机对照试验。236名有焦虑症状的学生在基线评估后被随机分配到VR干预组、安慰剂对照组或不活动对照组。我们开发了一个名为Mind Nature的VR干预系统,以自然为基础的活动为特色,如种植,观察自然环境,划船,个人反思,所有这些都伴随着一个完全沉浸式的360度三维VR环境中有意识的音频指导。安慰剂对照组使用VR头戴设备进行VR体育游戏,而对照组不接受任何干预。每次会议持续约30分钟。焦虑、情绪、压力、正念和与自然的关系分别在干预前和干预后以及两周的随访中进行了三次测量。结果显示,与安慰剂组和对照组相比,VR干预组的焦虑、负面情绪和压力的减少幅度更大。这项研究强调了基于虚拟现实的自然疗法的有效性,以及它作为一种有效和方便的大学生心理健康干预手段的潜力,为传统治疗方法提供了一种有希望的补充。该研究已在中国临床试验注册中心在线注册(ID: ChiCTR2400089445)。
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引用次数: 0
The role of baseline and persistent depression in adjuvant cancer therapy: impact on toxicity and quality of life 基线和持续性抑郁在辅助癌症治疗中的作用:对毒性和生活质量的影响
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100640
Berta Obispo , Caterina Calderon , Alberto Carmona-Bayonas , Ismael Ghanem , Juana Maria Cano-Cano , Paula Jiménez-Fonseca

Introduction

Depression is common among cancer patients, adversely affecting treatment adherence, toxicity, and quality of life (QoL). However, its course during adjuvant therapy and its impact on outcomes in resected cancer remain poorly understood. This study evaluated changes in depression from treatment initiation (T1) to six months later (T2) and examined associations with demographic, clinical, and psychological factors, treatment-related toxicities, and QoL.

Methods

In this multicenter, prospective observational study, 927 patients with resected, non-metastatic cancer receiving adjuvant treatment were enrolled. Depressive symptoms were measured using the Brief Symptom Inventory-18 (BSI-18) at T1 and T2. Patients were classified as “never” (no symptoms at T1 or T2), “new-onset” (absent at T1, present at T2), “remission” (present at T1, absent at T2), or “persistent” (present at both time points). Treatment-related toxicities were evaluated according to CTCAE v4.0, and QoL was assessed with the EORTC QLQ-C30.

Results

At T2, 50.8% of patients remained asymptomatic, 12.3% experienced remission, 23.4% exhibited persistent depression, and 13.5% developed new-onset depression. Persistent depression was more common among women, younger patients, those without a partner, and breast cancer patients. Patients with persistent symptoms showed significantly higher toxicities—including hematologic, digestive, and neuropathic events, as well as increased asthenia (p < .001)—and poorer functioning with greater symptom burden, resulting in markedly reduced overall QoL. In multivariate analyses, baseline depression and ECOG performance status were the main predictors of depressive symptoms at six months, while age predicted changes over time; other sociodemographic or clinical factors were not significant. Logistic regression confirmed that younger age, female sex, breast cancer, and poorer ECOG were associated with higher odds of persistent depression compared with never-depressed patients.

Conclusion

Both baseline depression and functional impairment (ECOG) are independent predictors of depressive symptoms during adjuvant therapy. Persistent depression is significantly associated with increased treatment toxicity and poorer QoL in patients with early-stage resected cancer, highlighting the need for routine screening and early psychological intervention during adjuvant treatment.
抑郁症在癌症患者中很常见,对治疗依从性、毒性和生活质量(QoL)产生不利影响。然而,它在辅助治疗中的过程及其对切除肿瘤预后的影响仍然知之甚少。本研究评估了从治疗开始(T1)到6个月后(T2)抑郁症的变化,并检查了与人口统计学、临床和心理因素、治疗相关毒性和生活质量的关系。方法在这项多中心前瞻性观察研究中,纳入了927例接受辅助治疗的非转移性肿瘤切除术患者。在T1和T2使用简短症状量表-18 (BSI-18)测量抑郁症状。患者被分为“从未”(T1或T2时无症状)、“新发”(T1时无症状,T2时有症状)、“缓解”(T1时有症状,T2时无症状)或“持续”(两个时间点均有症状)。采用CTCAE v4.0评价治疗相关毒性,采用EORTC QLQ-C30评价生活质量。结果在T2阶段,50.8%的患者无症状,12.3%的患者缓解,23.4%的患者表现为持续抑郁,13.5%的患者出现新发抑郁。持续抑郁在女性、年轻患者、没有伴侣的患者和乳腺癌患者中更为常见。持续症状的患者表现出明显更高的毒性——包括血液学、消化和神经病变事件,以及增加的虚弱(p < .001)——功能更差,症状负担更重,导致总体生活质量明显降低。在多变量分析中,基线抑郁和ECOG表现状态是6个月时抑郁症状的主要预测因素,而年龄预测随时间的变化;其他社会人口学或临床因素不显著。Logistic回归证实,与从未抑郁的患者相比,年龄较小、女性、乳腺癌和较差的ECOG与持续抑郁的几率较高相关。结论基线抑郁和功能障碍(ECOG)是辅助治疗期间抑郁症状的独立预测因子。在早期切除的癌症患者中,持续抑郁与治疗毒性增加和较差的生活质量显著相关,这突出了在辅助治疗期间进行常规筛查和早期心理干预的必要性。
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引用次数: 0
Group cohesion in online and in-person psychotherapy in a randomized control trial for cancer survivors 一项针对癌症幸存者的在线和面对面心理治疗的随机对照试验中的群体凝聚力
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100635
Alejandra Arizu-Onassis , Joan C. Medina , María Lleras de Frutos , Aida Flix-Valle , Maria Serra-Blasco , Laura Ciria-Suarez , Cristian Ochoa-Arnedo

Objective

To explore the role of group cohesion (GC) in-person positive group psychotherapy (PPPC) and online positive group psychotherapy (OPPC).

Method

A sample of 126 female cancer survivors experiencing emotional distress following primary oncological treatment was randomized to PPPC or OPPC. Measures of emotional distress, post-traumatic stress, and post-traumatic growth were taken at pre-treatment, post-treatment (after 12 weeks), and 3-month follow-up (from post-treatment), with GC assessed at post-treatment for this secondary analysis.

Results

There were no significant differences in GC levels between the PPPC and OPPC groups. Higher GC was associated with greater reductions in depressive symptoms (b= -0.80, CI(95 %)= -1.18 – -0.42, p< 0.001) and post-traumatic stress (b= -1.38, CI(95 %)= -2.42 – -0.34, p< 0.010) in both modalities. Participants with higher GC reported immediate post-traumatic growth at post-treatment, while those with lower GC achieved similar growth levels by 3-month follow-up. No specific sociodemographic or clinical variables were associated with higher GC.

Conclusions

In group psychotherapy for cancer survivors, GC is associated with a more pronounced reduction of depressive symptoms and post-traumatic stress, and with earlier post-traumatic growth in both OPPC and PPPC. Findings suggest that all cancer survivors have equal potential to develop GC, regardless of clinical or sociodemographic characteristics.
目的探讨群体凝聚力(GC)在现场积极群体心理治疗(PPPC)和网络积极群体心理治疗(OPPC)中的作用。方法选取126例原发性肿瘤治疗后出现情绪困扰的女性癌症幸存者,随机分为PPPC组和OPPC组。在治疗前、治疗后(12周后)和治疗后3个月的随访中测量情绪困扰、创伤后应激和创伤后成长,并在治疗后评估GC以进行二次分析。结果PPPC组与OPPC组血清GC水平无显著性差异。在两种治疗方式中,较高的GC均与抑郁症状(b= -0.80, CI(95%)= -1.18 - -0.42, p< 0.001)和创伤后应激(b= -1.38, CI(95%)= -2.42 - -0.34, p< 0.010)的显著减轻相关。GC较高的参与者在治疗后立即报告创伤后生长,而GC较低的参与者在3个月的随访中达到了相似的生长水平。没有特定的社会人口学或临床变量与较高的GC相关。结论在癌症幸存者的群体心理治疗中,GC与更明显的抑郁症状和创伤后应激减轻有关,与OPPC和PPPC的创伤后早期生长有关。研究结果表明,无论临床或社会人口学特征如何,所有癌症幸存者发展为胃癌的可能性相同。
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引用次数: 0
Examining sexual functioning and disgust in virtual reality: Low sexual interest/arousal and sexual pain moderate disgust toward sexual stimuli 研究虚拟现实中的性功能和厌恶:低性兴趣/性唤起和性疼痛对性刺激的中度厌恶
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100647
David Lafortune , Valérie A. Lapointe , Simon Dubé , Jonathan Bonneau , Natacha Godbout
Sexual dysfunctions are highly prevalent, affecting up to one-third of the adult population and significantly impacting mental well-being and intimate relationships. Virtual reality (VR) offers a promising and ecologically valid tool for studying psychological disorders; however, its application to research on sexual functioning remains underdeveloped. Sexual disgust is positively associated with sexual dysfunction symptoms, yet existing research remains scarce and has relied primarily on retrospective questionnaires and computer-based 2D erotic stimuli. This experimental study investigates whether low sexual functioning (i.e., low interest/arousal, lubrication/erection difficulties, orgasmic difficulties, and sexual pain) is linked to disgust toward virtual sexual cues. Seventy individuals completed self-reported measures of sexual functioning and disgust propensity. After completing a VR relaxation task, they participated in two VR-Behavior Avoidance Tests (VR-BAT): one sexual and one non-sexual. Disgust and sexual arousal were measured after the relaxation task and each VR-BAT. Participants also completed a sexual presence questionnaire post-immersion. Bivariate correlations and repeated-measures ANCOVAs were conducted. Results indicate that sexual disgust propensity is positively correlated with disgust ratings in the sexual VR-BAT, while sexual presence is positively associated with sexual arousal. Significant condition × sexual difficulties interaction effects show that reduced sexual interest/arousal and increased sexual pain are linked to heightened disgust exclusively in the sexual VR-BAT condition. These findings provide additional evidence that sexual disgust is associated with impaired sexual interest/arousal and sexual pain. This research highlights the value of VR sexual stimuli in studying sexual functioning and underscores the need for future studies to explore the potential of VR-based interventions in addressing the mechanisms underlying sexual dysfunctions and distress, including sexual disgust.
性功能障碍非常普遍,影响到多达三分之一的成年人口,并严重影响心理健康和亲密关系。虚拟现实(VR)为研究心理障碍提供了一个有前途和生态有效的工具;然而,它在性功能研究中的应用仍不发达。性厌恶与性功能障碍症状呈正相关,但现有的研究仍然很少,并且主要依赖于回顾性问卷调查和基于计算机的2D色情刺激。这项实验研究调查了低性功能(即低兴趣/觉醒、润滑/勃起困难、性高潮困难和性疼痛)是否与对虚拟性暗示的厌恶有关。70个人完成了性功能和厌恶倾向的自我报告测量。在完成虚拟现实放松任务后,他们参加了两个虚拟现实行为回避测试(VR- bat):一个是性的,一个是非性的。在放松任务和每次VR-BAT后测量厌恶和性唤起。参与者还在沉浸后完成了一份性存在问卷。进行了双变量相关性和重复测量ANCOVAs。结果表明,性厌恶倾向与性VR-BAT中的厌恶评分呈正相关,性存在与性唤起呈正相关。显著的条件-性困难相互作用效应表明,性兴趣/性唤起的降低和性疼痛的增加只与性VR-BAT条件下的厌恶感升高有关。这些发现提供了额外的证据,证明性厌恶与性兴趣/性唤起受损和性疼痛有关。本研究强调了虚拟现实性刺激在性功能研究中的价值,并强调了未来研究探索虚拟现实干预在解决性功能障碍和困扰(包括性厌恶)机制方面的潜力的必要性。
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引用次数: 0
A combined behavioral and EEG investigation of facial emotion recognition in sexual offenders against minors 针对未成年人的性犯罪者面部情绪识别的行为与脑电图联合研究
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100641
William Vallet , Sabine Mouchet , Mathias Poitau , Chloé Laval , Benoit Bediou , Guillaume Giret , Jerôme Brunelin
This study addresses a significant gap in literature by investigating emotional processing in sexual offenders against minors (SOm), using a combined electroencephalographic (EEG) and behavioral approach. In the first experiment, explicit behavioral abilities related to emotional recognition and the evaluation of perceived facial emotions were assessed in 15 SOm individuals, compared to 15 matched controls. In the second experiment, participants were asked to complete an implicit emotion task involving the presentation of emotional facial expressions while EEG activity was recorded. Behavioral results revealed a significant deficit in the recognition of fearful emotions, and an altered evaluation of the valence of disgusted emotional faces, in the SOm group compared to the control group. The implicit EEG results indicated a significantly lower amplitude in the P2-LPP temporal windows across temporo-parieto-occipital locations and modulated by the emotion and age of the presented faces. Taken together, these results highlight an emotional deficit in the SOm group, further reinforcing the hypothesis that this population has specific difficulty recognizing and interpreting emotional facial expressions, particularly those conveying negative emotions. These results represent a preliminary step toward a more comprehensive understanding of the cerebral underpinnings of emotional deficits in individuals who have committed sexual offenses against minors.
本研究利用脑电图与行为学相结合的方法,对性侵犯未成年人的情绪加工过程进行了研究,填补了文献研究的空白。在第一个实验中,研究人员对15名SOm个体进行了与情绪识别和面部情绪感知评估相关的外显行为能力评估,并与15名匹配的对照组进行了比较。在第二个实验中,参与者被要求完成一项内隐情绪任务,包括呈现情绪化的面部表情,同时记录脑电图活动。行为结果显示,与对照组相比,SOm组在识别恐惧情绪方面存在显著缺陷,对厌恶情绪面孔的效价评估也发生了改变。内隐脑电结果显示,被呈现面孔的情绪和年龄对P2-LPP颞窗的振幅有显著的调节作用。综上所述,这些结果突出了SOm组的情绪缺陷,进一步强化了这一人群在识别和解释情绪面部表情方面存在特殊困难的假设,尤其是那些传达负面情绪的面部表情。这些结果为更全面地了解对未成年人实施性侵犯的人的情感缺陷的大脑基础迈出了初步的一步。
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引用次数: 0
Attention training interventions for PTSD in bereaved Chinese parents who have lost their only child: A randomized controlled trial with behavioral and neuroimaging data 注意训练干预对中国失独父母PTSD的治疗:一项行为和神经影像学数据的随机对照试验
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100655
Buzohre Eli , Fei Xiao , Xuanang Liu , Madina Nijat , Zhengkui Liu

Background

: Attentional bias towards threat is a core mechanism underlying posttraumatic stress disorder (PTSD). Although attention bias modification (ABM) and attention control training (ACT) have been studied for PTSD, randomized controlled trials (RCTs) have reported inconsistent outcomes. Additionally, the nonemotional conditioning effect of ACT remains unvalidated. Shidu parents in China, a uniquely vulnerable group who have lost their only child, often suffer from severe and persistent PTSD, however, no RCT has yet investigated attention-based interventions among them. Thus, this RCT compared the efficacy of ABM, ACT, and attention control geometric training (ACG), which adapts ACT in a nonemotional context, on PTSD symptoms and dorsolateral prefrontal cortex (DLPFC) activity among Shidu parents.

Methods

: Participants were randomly assigned to the ABM (n = 21), ACT (n = 20), and ACG (n = 21) groups and completed eight biweekly sessions of ABM, ACT, and ACG, respectively. Symptoms, including PTSD clusters and anxiety as primary outcomes and PTSD total and depression as secondary outcomes, along with attentional bias were assessed at pre-treatment, mid-treatment, post-treatment, and a four-month follow-up. DLPFC activity was measured using functional near-infrared spectroscopy (fNIRS) at pre-treatment, mid-treatment and post-treatment.

Results

: ACT demonstrated significant improvement in intrusion symptoms, with treatment effects sustained at the four-month follow-up. However, other PTSD symptom clusters, as well as anxiety and depression, did not show significant improvement across any of the groups. At the neurocognitive level, ACT showed reduced vigilance toward threat and decrease in bilateral DLPFC activation under the vigilance condition. In contrast, ACG exhibited only a nonsignificant trend toward reduced vigilance to threat, along with reduction in left DLPFC activity under the same condition. ABM showed no significant improvements in either behavioral or neural measures.

Conclusions

: This study provides preliminary evidence that ACT may be a promising intervention for reducing intrusion symptoms and threat vigilance in Shidu parents, potentially through modulating DLPFC activation. These findings highlight the importance of targeting specific PTSD symptom clusters and corresponding neural pathways in future trauma interventions.
背景:威胁注意偏倚是创伤后应激障碍(PTSD)的核心机制。虽然注意偏倚矫正(ABM)和注意控制训练(ACT)已经被研究用于治疗创伤后应激障碍,但随机对照试验(rct)报告的结果不一致。此外,ACT的非情绪条件作用仍未得到证实。中国失独父母是一个独特的弱势群体,他们往往患有严重和持续性的创伤后应激障碍,然而,目前还没有RCT研究对他们进行基于注意力的干预。因此,本RCT比较了ABM、ACT和注意控制几何训练(ACG)对失都父母PTSD症状和背外侧前额叶皮层(DLPFC)活动的疗效。方法:参与者被随机分配到ABM (n = 21)、ACT (n = 20)和ACG (n = 21)组,并分别完成8次ABM、ACT和ACG的双周疗程。在治疗前、治疗中、治疗后和4个月的随访中评估症状,包括PTSD集群和焦虑作为主要结果,PTSD总量和抑郁作为次要结果,以及注意偏差。采用功能近红外光谱(fNIRS)测定处理前、处理中和处理后DLPFC的活性。结果:ACT对侵入症状有显著改善,治疗效果持续4个月。然而,其他创伤后应激障碍症状群,以及焦虑和抑郁,在任何一组中都没有显示出显著的改善。在神经认知水平上,ACT表现出对威胁的警觉性降低,警觉性条件下双侧DLPFC激活减少。相比之下,在相同的条件下,ACG只表现出对威胁的警觉性降低的不显著趋势,同时左侧DLPFC活动也有所减少。ABM在行为和神经测量方面都没有明显的改善。结论:本研究提供了初步证据,表明ACT可能是一种有希望的干预措施,可以通过调节DLPFC的激活来减轻十都父母的入侵症状和威胁警觉性。这些发现强调了在未来的创伤干预中,针对特定的PTSD症状群和相应的神经通路的重要性。
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引用次数: 0
Perseverative thinking, threat interpretation bias, and emotional reactivity as mediators between adverse childhood experience domains and psychopathology: A longitudinal mediation study in a cohort of Swiss emerging adults 持续性思维、威胁解释偏见和情绪反应作为不良童年经历域和精神病理之间的中介:一项瑞士新兴成人队列的纵向中介研究
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100654
Jeannette Brodbeck , Sofia Jacinto , Lina Stallmann , Neela Vetsch , Simon Marmet , Sharon A. Neufeld
Adverse Childhood Experiences (ACEs) are robust predictors of negative mental health outcomes and psychosocial difficulties, yet the psychological mechanisms linking ACEs to later psychopathology remain only partially understood. Drawing on a three-wave longitudinal study of Swiss emerging adults (N = 1934), we conducted longitudinal mediation analyses to examine emotional processing (emotional reactivity, perseverative thinking) and social information processing (threat interpretation bias, rejection sensitivity) as pathways from ACEs to psychopathology. Factor analyses identified three distinct ACE domains: family maltreatment, peer victimization, and sexual abuse. By modelling these domains simultaneously, we accounted for their frequent co-occurrence and isolated their unique contributions. Family maltreatment and peer victimization independently were associated with heightened psychopathology and difficulties with emotional processing and social information processing at Wave 1. Furthermore, both adversity domains also predicted persistent elevations in these domains over time, even after controlling for baseline levels and sociodemographic variables. Longitudinal mediation analyses revealed that family maltreatment and peer victimization both predicted psychopathology via perseverative thinking, threat interpretation bias, and emotional reactivity. Sexual abuse, in contrast, showed weaker or delayed associations with psychopathology and operated primarily through threat interpretation bias. Rejection sensitivity, while associated at the bivariate level, did not mediate longitudinal effects. Findings support and extend McLaughlin’s Model of Mechanisms Linking Childhood Trauma to Psychopathology by identifying distinct mediational pathways from specific ACEs to psychopathology. These distinct pathways underscore the relevance of personalized and mechanism-based treatment planning based on the ACEs experienced.
不良童年经历(ace)是负面心理健康结果和社会心理困难的有力预测因素,然而,将ace与后来的精神病理联系起来的心理机制仅部分被理解。利用一项瑞士新生成人(N = 1934)的三波纵向研究,我们进行了纵向中介分析,以检验情绪加工(情绪反应性、持续性思维)和社会信息加工(威胁解释偏见、拒绝敏感性)作为从ace到精神病理的途径。因素分析确定了三个不同的ACE领域:家庭虐待、同伴受害和性虐待。通过同时对这些域进行建模,我们解释了它们的频繁共存,并分离了它们的独特贡献。在第一阶段,家庭虐待和同伴受害分别与精神病理升高、情绪处理和社会信息处理困难相关。此外,即使在控制了基线水平和社会人口变量之后,这两个逆境域也预测了这些域随时间的持续升高。纵向中介分析显示,家庭虐待和同伴受害均通过持续性思维、威胁解释偏见和情绪反应来预测精神病理。相比之下,性虐待与精神病理的关联较弱或较晚,主要通过威胁解释偏见来运作。排斥敏感性虽然与双变量水平相关,但不介导纵向效应。研究结果支持并扩展了McLaughlin的童年创伤与精神病理学联系机制模型,确定了从特定ace到精神病理学的不同中介途径。这些不同的途径强调了基于ace经验的个性化和基于机制的治疗计划的相关性。
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引用次数: 0
Sleep health as a predictor of the course of depressed mood and loss of interest in individuals with depression 睡眠健康作为抑郁症患者抑郁情绪进程和兴趣丧失的预测因子
IF 4.4 1区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-01 DOI: 10.1016/j.ijchp.2025.100653
Sarah R. Schmid , Julian E. Schiel , Bernd Feige , Florian Holub , Elisabeth Hertenstein , Katharina Domschke , Martin K. Rutter , Kai Spiegelhalder

Background

Sleep health is a significant risk factor for incident depression. Much less is known about the impact of sleep health on the course of depressive symptoms in those who have already developed the disorder. The present study used longitudinal data of individuals with a depression diagnosis from the UK Biobank to analyse sleep health as a potential predictor for the course of depressive symptoms. The hypothesis was that better sleep health would predict a milder course of depressed mood and loss of interest.

Methods

Self-reported insomnia symptoms, sleep duration, chronotype and daytime sleepiness were assessed as predictors at baseline. Depressive symptoms were self-reported and assessed at baseline and at follow-up, 8.76 ± 3.00 years after the baseline assessment. Linear regression models were calculated for each outcome variable.

Results

The study comprised 4817 participants. Frequent insomnia symptoms and daytime sleepiness predicted a worse course of depressed mood (insomnia: β = 0.31 ± 0.10, p = 0.002; daytime sleepiness: β = 0.45 ± 0.11, p < 0.001) and loss of interest (insomnia: β = 0.30 ± 0.11, p = 0.005; daytime sleepiness: β = 0.32 ± 0.11, p = 0.003). On the contrary, early chronotype (β = -0.27 ± 0.10, p = 0.008) predicted a milder course of loss of interest.

Conclusion

Our findings suggest that sleep health variables have a significant impact on the course of depressive symptoms in a sample with clinically diagnosed depression. Future research may investigate the add-on effects of sleep health improvements in patients with depression receiving guideline-concordant treatment.
背景:睡眠健康是偶发性抑郁症的重要风险因素。对于那些已经患有抑郁症的人来说,睡眠健康对其抑郁症状的影响知之甚少。目前的研究使用来自英国生物银行的抑郁症诊断个体的纵向数据来分析睡眠健康作为抑郁症状过程的潜在预测因子。他们的假设是,更好的睡眠健康预示着抑郁情绪和失去兴趣的过程会更温和。方法以自我报告的失眠症状、睡眠时间、睡眠类型和白天嗜睡作为基线预测指标。在基线评估后8.76±3.00年,自我报告抑郁症状并在基线和随访时进行评估。对每个结果变量计算线性回归模型。结果本研究共纳入4817名参与者。频繁的失眠症状和白天嗜睡预示着更严重的抑郁情绪(失眠:β = 0.31±0.10,p = 0.002;白天嗜睡:β = 0.45±0.11,p < 0.001)和兴趣丧失(失眠:β = 0.30±0.11,p = 0.005;白天嗜睡:β = 0.32±0.11,p = 0.003)。相反,较早的睡眠类型(β = -0.27±0.10,p = 0.008)预示着较轻的兴趣丧失过程。结论睡眠健康变量对临床诊断为抑郁症的患者抑郁症状的病程有显著影响。未来的研究可能会调查睡眠健康改善对接受指南一致性治疗的抑郁症患者的附加效应。
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引用次数: 0
期刊
International Journal of Clinical and Health Psychology
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