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Impact of pharmacist-led antibiotic stewardship audit-feedback intervention; systematic review and meta-analysis. 药师主导的抗生素管理审计反馈干预的影响系统回顾和荟萃分析。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-11-24 DOI: 10.1016/j.sapharm.2025.11.002
Duaa Salem Jawhar, Amer Hayat Khan, Khurshid Alam, Rabbiya Ahmad

Background: The escalating threat of antimicrobial resistance continues to burden healthcare systems globally. Antimicrobial stewardship programs (ASPs) are recognized as a cornerstone strategy to mitigate inappropriate antibiotic use and curb resistance. Despite their growing implementation, the impact of pharmacist-led audit and feedback interventions within ASPs remains insufficiently explored.

Objective: To synthesize the evidence on the effect of pharmacist-led audit-feedback interventions within ASPs.

Methods: In accordance with PRISMA guidelines, the pooled estimate of pharmacist-led ASP audit-feedback interventions was calculated using a random-effects model. The Cochrane risk of bias tools were employed to assess the quality of the studies. We searched PubMed, SCOPUS, EBSCO/CINAHL, and Web of Science from January 1, 2000, to June 30, 2024. We included randomized controlled trials, cohort studies, case-control studies, and quasi-experimental studies. Sensitivity analyses were conducted using the leave-one-out method. Publication bias was assessed through funnel plot and Egger's regression test. Study protocol registered with PROSPERO (CRD420251036088).

Results: A total of 69,666 studies were screened, with 14 ultimately included in the final qualitative and quantitative analysis. Including 17805 patients in the pooled analysis. Pharmacist-led ASP audit-feedback intervention associated with reduction in antibiotic days of therapy, length of hospital stay (MD = -5.93, 95 % CI -12.90-1.03, I2 97.7 %), significant increase in appropriate antibiotic prescribing practice (OR 2.72, 95 % CI 1.51-4.88, I2 75 %) and 25 % reduction in mortality (OR 0.75, 95 % CI 0.55-1.03, I2 88 %) CONCLUSION: This systematic review and meta-analysis provide growing evidence that pharmacist-led audit and feedback interventions within ASPs are associated with a significant improvement in appropriate antibiotic prescribing and reduction in mortality, length of hospital stay, and days of therapy. These findings support the integration of pharmacists as key leaders in ASPs and highlight the potential for policymakers to prioritize investment in pharmacist-led stewardship roles.

背景:不断升级的抗菌素耐药性威胁继续给全球卫生保健系统带来负担。抗菌药物管理规划(asp)被认为是减少抗生素不当使用和抑制耐药性的基石战略。尽管越来越多地实施,但药剂师主导的审计和反馈干预在asp中的影响仍未得到充分探索。目的:综合评价药师主导的审计反馈干预在asp中的效果。方法:根据PRISMA指南,采用随机效应模型计算药师主导的ASP审计反馈干预的汇总估计。采用Cochrane偏倚风险工具评估研究质量。我们检索了2000年1月1日至2024年6月30日期间的PubMed、SCOPUS、EBSCO/CINAHL和Web of Science。我们纳入了随机对照试验、队列研究、病例对照研究和准实验研究。采用留一法进行敏感性分析。通过漏斗图和Egger回归检验评估发表偏倚。研究方案已在PROSPERO注册(CRD420251036088)。结果:共筛选69,666项研究,其中14项最终纳入最终的定性和定量分析。共纳入17805例患者。药师主导的ASP审计反馈干预与减少抗生素治疗天数、住院时间(MD = -5.93, 95% CI -12.90-1.03, I2 97.7%)、显著增加适当的抗生素处方实践(OR 2.72, 95% CI 1.51-4.88, I2 75%)和降低25%的死亡率(OR 0.75, 95% CI 0.55-1.03, I2 88%)相关。该系统综述和荟萃分析提供了越来越多的证据,表明药师主导的asp内审计和反馈干预与适当抗生素处方的显著改善和死亡率、住院时间和治疗天数的减少有关。这些发现支持药剂师作为asp的关键领导者的整合,并强调了政策制定者优先投资药剂师领导的管理角色的潜力。
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引用次数: 0
From pill to purpose: Rethinking outcomes evaluation through patient-centered metrics in pharmacoepidemiology and chronic disease management 从药丸到目的:通过药物流行病学和慢性疾病管理中以患者为中心的指标重新思考结果评估。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-11-17 DOI: 10.1016/j.sapharm.2025.11.001
Mohamed AbdElrahman , Mohammed D. Al-Rekabi , Mohamed E.A. Abdelrahim
Despite progress in medication and evidence-based protocols, a disparity persists between clinical outcomes and patients lived experiences. Conventional pharmacoepidemiologic metrics—such as biomarker targets or hospitalization rates—frequently do not capture what patients prioritize: functionality, autonomy, and quality of life. This article promotes a transition to patient-centered measures, such as patient-reported outcomes (PROs), goal attainment scaling (GAS), and behavioral adherence models. By incorporating these approaches into research and practice, healthcare systems can more effectively assess therapy efficacy in real-world settings. The opinion emphasizes data that supports Patient-Reported Outcomes (PROs) and Goal Attainment Scaling (GAS), addresses implementation problems, and advocates for the realignment of assessment systems towards purpose-driven care. Ultimately, aligning outcome evaluation with patients' objectives promotes relevance, equity, and participation in chronic disease management—prompting pharmacoepidemiology to evaluate not only the efficacy of pharmaceuticals but also their meaningful impact on the lives of users.
尽管在药物治疗和循证协议方面取得了进展,但临床结果和患者生活经历之间仍然存在差距。传统的药物流行病学指标——如生物标志物目标或住院率——经常不能捕捉到患者优先考虑的问题:功能、自主性和生活质量。本文促进了向以患者为中心的措施的过渡,例如患者报告的结果(PROs)、目标实现缩放(GAS)和行为依从性模型。通过将这些方法纳入研究和实践,医疗保健系统可以更有效地评估现实世界环境中的治疗效果。该意见强调支持患者报告结果(PROs)和目标实现尺度(GAS)的数据,解决实施问题,并倡导将评估系统重新调整为目的驱动型护理。最终,将结果评估与患者的目标相一致,促进了慢性病管理的相关性、公平性和参与性——促使药物流行病学不仅评估药物的疗效,而且评估它们对使用者生活的有意义的影响。
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引用次数: 0
A survey of open science attitudes and behaviors among US pharmacy faculty 美国药学教师开放科学态度和行为的调查。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-11-07 DOI: 10.1016/j.sapharm.2025.10.012
Spencer E. Harpe

Objectives

To describe the attitudes, behaviors, and perceived disciplinary norms for open science practices among US pharmacy faculty and examine differences across pharmacy disciplines.

Methods

This cross-sectional study used the Center for Open Science's Open Scholarship Survey modules on data sharing, code sharing, materials sharing, preregistration, preprints, and open access publishing. Attitudes were measured using a scale from 1 (Very much against) to 5 (Very much in favor). The study questionnaire was administered to a random sample of 3200 faculty from the AACP Roster of Pharmacy Faculty as of February 2022. Individuals with ≥0.8 full-time equivalent faculty appointment in pharmacy practice or one of the pharmaceutical sciences were eligible to participate.

Results

Responses were obtained from 663 faculty (389 complete; 274 partial). Open access publishing (mean [SD]: 4.1 [0.9]) showed the most positive attitudes. Study preregistration (3.2 [0.9]) and posting preprints (3.1 [1.1]) were the least positive. Attitudes for data sharing, code sharing, and study preregistration were statistically significant across disciplines. The most commonly reported open science practice was open access publishing (mean [SD], 27.7 % [29.1 %]). Study preregistration was the least common (mean [SD], 1.7 % [7.0 %]). After accounting for respondent and institutional characteristics, disciplinary differences in data sharing, study preregistration, and posting preprints were noted.

Conclusion

This study provides a baseline assessment of attitudes towards and engagement in open science practices among US pharmacy faculty. Given the relatively low frequency with which open science practices were reported, there is considerable room for improvement in the uptake of open science practices.
目的:描述美国药学教师对开放科学实践的态度、行为和感知的学科规范,并检查药学学科之间的差异。方法:这项横断面研究使用了开放科学中心的开放奖学金调查模块,包括数据共享、代码共享、材料共享、预注册、预印本和开放获取出版。态度是用1(非常反对)到5(非常赞成)的等级来衡量的。截至2022年2月,该研究问卷随机抽取了AACP药学院名单中的3200名教师。在药学实践或某一药学科学领域拥有≥0.8个全职同等教员职位的个人有资格参加研究。结果:663名教师(389名完整,274名不完整)回复。开放获取出版(mean [SD]: 4.1[0.9])表现出最积极的态度。研究预注册(3.2[0.9])和发布预印本(3.1[1.1])是最不积极的。对数据共享、代码共享和研究预注册的态度在各学科之间具有统计学意义。最常报道的开放科学实践是开放获取出版(mean [SD], 27.7%[29.1%])。研究预登记是最不常见的(平均[SD], 1.7%[7.0%])。在考虑了调查对象和机构的特点后,我们注意到在数据共享、研究预登记和发布预印本方面的学科差异。结论:本研究提供了对开放科学实践的态度和参与在美国药学教师的基线评估。鉴于开放科学实践报告的频率相对较低,在开放科学实践的吸收方面有相当大的改进空间。
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引用次数: 0
Racial and socioeconomic disparities in the utilization of diabetes medication: A comprehensive analysis of NHANES 2011–2023 糖尿病药物使用中的种族和社会经济差异:NHANES 2011-2023的综合分析
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-10-31 DOI: 10.1016/j.sapharm.2025.10.013
Rawan O. Almadfaa

Objective

To examine the association between racial and socioeconomic health disparities and diabetes medications utilization using a nationally representative sample of the US population.

Method

This study included 4469 diabetic patients (weighted N = 23,678,032) aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) 2011–2023. Patients were classified into four groups based on medication use: insulin only, noninsulin glucose-lowering drugs (GLDs), both, or none. Univariate, bivariate, and multinomial logistic regression analyses were performed to assess associations between medication use and health disparities. All analyses were weighted for the survey's complex, multistage design of NHANES.

Results

Among the 4469 patients, 579 used insulin, 2411 used noninsulin GLDs, 754 used both, and 725 were untreated. Older patients had higher odds of using non-insulin GLDs (OR = 1.018, 95 % CI: 1.009–1.027) and both therapies (OR = 1.012, 95 % CI: 1.001–1.022) compared with younger adults. Males were more likely to use diabetes medications than females. Asians had higher odds of medication use, while other racial groups had lower odds than Whites. Participants with income higher income had lower odds of using both insulin and non-insulin GLDs (OR = 0.708, 95 % CI: 0.521–0.964) compared with those with lower income. Insured patients were more likely to use medications than the uninsured. Education level and marital status were not significantly associated with diabetes medication utilization.

Conclusion

This study identified demographic and socioeconomic differences in diabetes medication utilization among U.S. adults. Lower odds of medication use were observed among Mexican American, other Hispanic, other race group, females, and uninsured participants, as well as those with higher income, indicating potential gaps in equitable diabetes management. Targeted interventions to improve medication access and adherence among these groups are needed to promote more equitable diabetes care in the U.S.
目的:研究种族和社会经济健康差异与糖尿病药物使用之间的关系,使用具有全国代表性的美国人口样本。方法:本研究纳入2011-2023年全国健康与营养调查(NHANES)中年龄≥20岁的4469例糖尿病患者(加权N = 23,678,032)。根据用药情况将患者分为四组:仅使用胰岛素、非胰岛素降糖药物(GLDs)、两者都使用或不使用。采用单变量、双变量和多项逻辑回归分析来评估药物使用与健康差异之间的关联。所有的分析都是加权的,因为调查是复杂的,NHANES的多阶段设计。结果:4469例患者中,579例使用胰岛素,2411例使用非胰岛素gld, 754例两者都使用,725例未经治疗。与年轻人相比,老年患者使用非胰岛素GLDs (OR = 1.018, 95% CI: 1.009-1.027)和两种治疗方法(OR = 1.012, 95% CI: 1.001-1.022)的几率更高。男性比女性更有可能使用糖尿病药物。亚洲人使用药物的几率更高,而其他种族的几率低于白人。与收入较低的参与者相比,收入较高的参与者使用胰岛素和非胰岛素GLDs的几率较低(OR = 0.708, 95% CI: 0.521-0.964)。有保险的患者比没有保险的患者更有可能使用药物。教育程度、婚姻状况与糖尿病药物使用无显著相关。结论:本研究确定了美国成年人糖尿病药物使用的人口统计学和社会经济差异。在墨西哥裔美国人、其他西班牙裔、其他种族、女性、无保险参与者以及高收入人群中观察到较低的药物使用几率,这表明在公平的糖尿病管理方面存在潜在差距。在美国,需要有针对性的干预措施来改善这些群体的药物获取和依从性,以促进更公平的糖尿病护理
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引用次数: 0
A multisite pilot type 2 hybrid implementation-effectiveness trial of a community pharmacist-led model of collaborative care for Medication Assisted Treatment for Opioid Dependence: outcomes of the EPIC-MATOD trial 一项社区药剂师主导的阿片类药物依赖药物辅助治疗协同护理模式的多站点2型混合实施-有效性试验:EPIC-MATOD试验的结果
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-10-29 DOI: 10.1016/j.sapharm.2025.10.009
Suzanne Nielsen , Francis Graham , Mohammad Hossein Hadi , Elizabeth Grist , Bosco Rowland , John Jackson , Sarah Lord , Jana Dostal , Pene Wood , Kirsty Morgan , Dennis Petrie , Ali Cheetham

Background

Australia faces a critical challenge with access to opioid dependence treatment, particularly in regional areas where treatment shortages are amplified.

Objective

(s): To assess outcomes of a collaborative care model for opioid dependence treatment where community pharmacists work to their full scope of practice, in partnership with prescribers.

Methods

Community pharmacists and prescribers were recruited from the south-eastern suburbs of Melbourne, Victoria, Australia, to take part in a prospective, multisite, Type 2 hybrid implementation-effectiveness trial. Patients received collaborative prescriber/pharmacist care over a 6-month period, with outcomes compared to a non-randomised comparison group receiving usual care. Data was collected using a mixed methods approach with outcomes mapped to the RE-AIM framework. A health economics evaluation established time and costs associated with collaborative care.

Results

Collaborative care provided comparable outcomes on retention in treatment (97.2 %, 35/36) compared to the control cohort (89.8 %, 44/49) with no significant differences between groups on substance use or mental or physical health outcomes. Collaborative care was associated with significant increases in treatment satisfaction and quality adjusted life years (QALYs) and was cost-effective when compared to treatment as usual. The model was implemented with relatively high fidelity, with high levels of satisfaction among pharmacists, prescribers, and patients. Considerations for broader implementation included pharmacist workload, the need for secure communication software, and a mechanism to remunerate pharmacists for their time providing clinical care.

Conclusion

Pharmacist-led collaborative care for opioid dependence is feasible and acceptable and can provide an at least equivalent standard of care to usual care. Further research is required to establish how collaborative care can maximise prescriber capacity at scale.

Clinical Trial registration

ACTRN12621000871842.
背景:澳大利亚在获得阿片类药物依赖治疗方面面临严峻挑战,特别是在治疗短缺加剧的区域地区。目的:评估阿片类药物依赖治疗的合作护理模式的结果,在这种模式下,社区药剂师与开处方者合作,充分发挥其实践范围。方法:从澳大利亚维多利亚州墨尔本东南郊区招募社区药剂师和开处方者,参与一项前瞻性、多地点、2型混合实施-有效性试验。患者在6个月的时间里接受了处方医生/药剂师的合作护理,结果与接受常规护理的非随机对照组相比。采用混合方法收集数据,并将结果映射到RE-AIM框架。卫生经济学评估确定了与协作护理相关的时间和成本。结果:与对照组(89.8%,44/49)相比,协作治疗在治疗保留率(97.2%,35/36)方面提供了相当的结果,两组之间在药物使用或精神或身体健康结果方面没有显著差异。与常规治疗相比,协作治疗与治疗满意度和质量调整生命年(QALYs)的显著增加有关,并且具有成本效益。该模型的实施具有较高的保真度,药师、开处方者和患者的满意度较高。更广泛实施的考虑因素包括药剂师的工作量,对安全通信软件的需求,以及对药剂师提供临床护理的时间进行奖励的机制。结论:药师主导的阿片类药物依赖协同护理是可行和可接受的,可以提供至少相当于常规护理标准的护理。需要进一步的研究来确定协作护理如何在规模上最大化开处方者的能力。临床试验注册:ACTRN12621000871842。
{"title":"A multisite pilot type 2 hybrid implementation-effectiveness trial of a community pharmacist-led model of collaborative care for Medication Assisted Treatment for Opioid Dependence: outcomes of the EPIC-MATOD trial","authors":"Suzanne Nielsen ,&nbsp;Francis Graham ,&nbsp;Mohammad Hossein Hadi ,&nbsp;Elizabeth Grist ,&nbsp;Bosco Rowland ,&nbsp;John Jackson ,&nbsp;Sarah Lord ,&nbsp;Jana Dostal ,&nbsp;Pene Wood ,&nbsp;Kirsty Morgan ,&nbsp;Dennis Petrie ,&nbsp;Ali Cheetham","doi":"10.1016/j.sapharm.2025.10.009","DOIUrl":"10.1016/j.sapharm.2025.10.009","url":null,"abstract":"<div><h3>Background</h3><div>Australia faces a critical challenge with access to opioid dependence treatment, particularly in regional areas where treatment shortages are amplified.</div></div><div><h3>Objective</h3><div>(s): To assess outcomes of a collaborative care model for opioid dependence treatment where community pharmacists work to their full scope of practice, in partnership with prescribers.</div></div><div><h3>Methods</h3><div>Community pharmacists and prescribers were recruited from the south-eastern suburbs of Melbourne, Victoria, Australia, to take part in a prospective, multisite, Type 2 hybrid implementation-effectiveness trial. Patients received collaborative prescriber/pharmacist care over a 6-month period, with outcomes compared to a non-randomised comparison group receiving usual care. Data was collected using a mixed methods approach with outcomes mapped to the RE-AIM framework. A health economics evaluation established time and costs associated with collaborative care.</div></div><div><h3>Results</h3><div>Collaborative care provided comparable outcomes on retention in treatment (97.2 %, 35/36) compared to the control cohort (89.8 %, 44/49) with no significant differences between groups on substance use or mental or physical health outcomes. Collaborative care was associated with significant increases in treatment satisfaction and quality adjusted life years (QALYs) and was cost-effective when compared to treatment as usual. The model was implemented with relatively high fidelity, with high levels of satisfaction among pharmacists, prescribers, and patients. Considerations for broader implementation included pharmacist workload, the need for secure communication software, and a mechanism to remunerate pharmacists for their time providing clinical care.</div></div><div><h3>Conclusion</h3><div>Pharmacist-led collaborative care for opioid dependence is feasible and acceptable and can provide an at least equivalent standard of care to usual care. Further research is required to establish how collaborative care can maximise prescriber capacity at scale.</div></div><div><h3>Clinical Trial registration</h3><div>ACTRN12621000871842.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"22 2","pages":"Pages 292-310"},"PeriodicalIF":2.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causes and management of drug shortages: A scoping review 药品短缺的原因和管理:范围审查。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-10-25 DOI: 10.1016/j.sapharm.2025.10.008
N. Cornelissen , S.W. Zielhuis , P.M.L.A. van den Bemt , B.J.F. van den Bemt

Background

Drug shortages form a significant global challenge and may lead to treatment delays, increased healthcare costs, and negative health outcomes. Gaining more insight into the causes is crucial to develop interventions to prevent shortages and manage their consequences. This scoping review aims to provide an overview of the causes and management of drug shortages in high-income countries.

Methods

This scoping review was conducted in accordance with the JBI methodology. A comprehensive search was performed in PubMed, EMBASE, Web of Science, and CENTRAL on December 21, 2023. Studies published in English or Dutch on the causes and management of drug shortages in high-income countries were included. Two reviewers independently screened titles/abstracts and full texts. Relevant data on study characteristics, causes, and interventions were extracted using a standardized form. Findings were analysed descriptively.

Results

Thirty-six studies were included out of 4531 citations. Causes of drug shortages included manufacturing issues, fluctuating demand and market forces, poor supply chain management, political and strategic decisions, and external influences. Several studies emphasized that causes were frequently unknown. Interventions to manage shortages focused on alternatives and substitutions, inventory management, communication and coordination, regulatory and policy measures, and forecasting. While causes are primarily linked to early stages of the product life cycle, most interventions occur at later stages and tend to be reactive.

Conclusions

Most current interventions focus on temporary solutions at the end of the supply chain, while shortages often originate earlier. A focus on early-stage causes is needed for more effective, preventive solutions.
背景:药物短缺是一项重大的全球挑战,可能导致治疗延误、医疗保健费用增加和负面的健康结果。深入了解原因对于制定预防短缺和管理其后果的干预措施至关重要。这一范围审查的目的是概述高收入国家药物短缺的原因和管理。方法:本综述按照JBI方法学进行。我们于2023年12月21日在PubMed、EMBASE、Web of Science和CENTRAL进行了全面的检索。以英语或荷兰语发表的关于高收入国家药品短缺原因和管理的研究也包括在内。两位审稿人独立筛选标题/摘要和全文。使用标准化表格提取有关研究特征、原因和干预措施的相关数据。对研究结果进行描述性分析。结果:在4531次引用中,共纳入36篇研究。药品短缺的原因包括生产问题、需求和市场力量波动、供应链管理不善、政治和战略决策以及外部影响。几项研究强调,原因往往是未知的。管理短缺的干预措施侧重于替代品和替代、库存管理、沟通和协调、监管和政策措施以及预测。虽然原因主要与产品生命周期的早期阶段有关,但大多数干预措施发生在后期阶段,往往是被动的。结论:目前大多数干预措施侧重于供应链末端的临时解决方案,而短缺往往发生在更早的时候。需要把重点放在早期原因上,以获得更有效的预防性解决办法。
{"title":"Causes and management of drug shortages: A scoping review","authors":"N. Cornelissen ,&nbsp;S.W. Zielhuis ,&nbsp;P.M.L.A. van den Bemt ,&nbsp;B.J.F. van den Bemt","doi":"10.1016/j.sapharm.2025.10.008","DOIUrl":"10.1016/j.sapharm.2025.10.008","url":null,"abstract":"<div><h3>Background</h3><div>Drug shortages form a significant global challenge and may lead to treatment delays, increased healthcare costs, and negative health outcomes. Gaining more insight into the causes is crucial to develop interventions to prevent shortages and manage their consequences. This scoping review aims to provide an overview of the causes and management of drug shortages in high-income countries.</div></div><div><h3>Methods</h3><div>This scoping review was conducted in accordance with the JBI methodology. A comprehensive search was performed in PubMed, EMBASE, Web of Science, and CENTRAL on December 21, 2023. Studies published in English or Dutch on the causes and management of drug shortages in high-income countries were included. Two reviewers independently screened titles/abstracts and full texts. Relevant data on study characteristics, causes, and interventions were extracted using a standardized form. Findings were analysed descriptively.</div></div><div><h3>Results</h3><div>Thirty-six studies were included out of 4531 citations. Causes of drug shortages included manufacturing issues, fluctuating demand and market forces, poor supply chain management, political and strategic decisions, and external influences. Several studies emphasized that causes were frequently unknown. Interventions to manage shortages focused on alternatives and substitutions, inventory management, communication and coordination, regulatory and policy measures, and forecasting. While causes are primarily linked to early stages of the product life cycle, most interventions occur at later stages and tend to be reactive.</div></div><div><h3>Conclusions</h3><div>Most current interventions focus on temporary solutions at the end of the supply chain, while shortages often originate earlier. A focus on early-stage causes is needed for more effective, preventive solutions.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"22 2","pages":"Pages 232-253"},"PeriodicalIF":2.8,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145410433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Academic community pharmacy: A pilot Delphi study aimed at establishing a future common definition at the international level 学术社区药房:一项试点德尔菲研究,旨在建立未来国际层面的共同定义。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-10-23 DOI: 10.1016/j.sapharm.2025.10.011
Clémence Perraudin , Noelia Amador-Fernandez , Marie Paule Schneider , Florent Macé , Ralitza Gauthier , Alice Panchaud , Samuel Allemann , Stefan Erni , Jérôme Berger

Introduction

The Granada statements promote the consistent use of appropriate terminology in pharmacy practice research. This pilot study aims to define the term Academic Community Pharmacy (ACP), providing a foundation for a forthcoming international study aimed at establishing a globally accepted definition.

Methodology

A Delphi study was conducted in 2023 among academic entities from all five Swiss universities involved in pharmacy practice research and education. The first definition comprised four kex elements: place of practice, clinical and academic activities and links with universities. Anonymous survey rounds were conducted where panellists assessed agreement with and clarity of the statements using a Likert scale. Additionally, free comments and proposals for changes were allowed. Consensus for each statement was defined as ≥66 % agreement.

Results

The panel consisted of nine members. Two Delphi rounds were needed to reach consensus for the final definition: “An ACP is a facility providing professional pharmacy services (according to a commonly accepted definition in the location of the considered ACP) to the community, conducting research and education on such services, and that has formal links (e.g., financial or contractual) with a university”.

Conclusion

Establishing a clear and consistent definition of ACPs will support their characterization and further development.
简介:格拉纳达声明促进了在药学实践研究中适当术语的一致使用。本试点研究旨在定义学术社区药学(ACP)一词,为即将开展的旨在建立全球公认定义的国际研究奠定基础。方法:在2023年对瑞士所有五所涉及药学实践研究和教育的大学的学术实体进行了德尔菲研究。第一个定义包括四个关键要素:实践地点、临床和学术活动以及与大学的联系。进行了几轮匿名调查,小组成员使用李克特量表评估对陈述的同意程度和清晰度。此外,还允许对更改提供免费评论和建议。每个陈述的一致性定义为≥66%的一致性。结果:小组由九名成员组成。最后的定义需要经过两轮德尔菲讨论才能达成共识:“ACP是向社区提供专业药学服务(根据考虑的ACP所在地普遍接受的定义),并就此类服务进行研究和教育的设施,并且与大学有正式联系(例如,财务或合同)”。结论:建立一个清晰、一致的acp定义将有助于其表征和进一步发展。
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引用次数: 0
PharmaCenter: Impact of post-discharge pharmaceutical carea consultation on medication-related problems in the emergenc department: A comprehensive analysis 药师:出院后药学服务会诊对急诊科用药相关问题的影响——综合分析
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-10-22 DOI: 10.1016/j.sapharm.2025.10.010
Beatriz Torroba-Sanz , Ana De Lorenzo-Pinto , Álvaro Giménez-Manzorro , Carmen Redondo-Galán , Daniel Gómez-Costas , Juana Benedí , Ana Herranz-Alonso , Maria Sanjurjo-Sáez

Background

Transitions of care, particularly after discharge from hospital emergency services, are critical periods associated with a high risk of medication-related problems. These often arise from communication failures and incomplete pharmacotherapeutic information. PharmaCenter was established as a pharmacist-led consultation service designed to manage pharmacotherapeutic queries arising after hospital discharge.

Objective

To describe the implementation of PharmaCenter and evaluate its clinical performance. Secondary objectives included assessing its capacity to resolve medication-related problems, analyzing service accessibility and usability, and evaluating patient satisfaction.

Methods

A retrospective observational study was conducted over two years in a tertiary teaching hospital. The service was available 24 h a day, seven days a week, providing patients discharged from three emergency departments with access to consultation by telephone or email. Each query was analyzed in terms of origin, time to consultation, time to resolution, and need for physician involvement. A structured survey was used to assess patient satisfaction.

Results

Over the study period, 1485 patients used the service, generating 1626 consultations. Most queries originated from adult emergency care. The median time from discharge to consultation was 2.33 days, and the mean resolution time was 1.36 h. In 54.1 percent of cases, pharmacists provided a complete response without physician input. The most frequent issue was failure to prescribe medications in the electronic prescribing system. Among respondents to the satisfaction survey, 93.9 percent indicated the service helped avoid a return to a healthcare facility.

Conclusions

PharmaCenter effectively addressed post-discharge medication-related problems and demonstrated high levels of patient satisfaction, offering a scalable model to support safer transitions of care.
背景:护理过渡期,特别是从医院急诊服务出院后,是与药物相关问题高风险相关的关键时期。这通常是由于沟通失败和药物治疗信息不完整造成的。PharmaCenter是一个药剂师主导的咨询服务,旨在管理出院后产生的药物治疗问题。目的:介绍药学中心的实施情况,评价其临床效果。次要目标包括评估其解决药物相关问题的能力,分析服务的可及性和可用性,以及评估患者满意度。方法:在某三级教学医院进行为期两年的回顾性观察研究。该服务每周7天、每天24小时提供,为从三个急诊科出院的病人提供电话或电子邮件咨询服务。分析每个查询的来源、咨询时间、解决时间和医生参与的需要。采用结构化调查来评估患者满意度。结果:在研究期间,1485名患者使用了这项服务,产生了1626次咨询。大多数查询来自成人急诊护理。从出院到会诊的中位时间为2.33天,平均解决时间为1.36小时。在54.1%的病例中,药剂师在没有医生输入的情况下提供了完整的响应。最常见的问题是未能在电子处方系统中开药。在满意度调查的受访者中,93.9%的人表示,这项服务有助于避免再次回到医疗机构。结论:PharmaCenter有效地解决了出院后药物相关问题,并展示了高水平的患者满意度,提供了一个可扩展的模型来支持更安全的护理过渡。
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引用次数: 0
Impact of pharmacist-led interventions on economic, clinical, and humanistic outcomes (ECHO) in patients admitted to emergency departments: A systematic review of randomized controlled trials 药剂师主导的干预措施对急诊科入院患者的经济、临床和人文预后(ECHO)的影响:随机对照试验的系统综述
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-10-21 DOI: 10.1016/j.sapharm.2025.10.007
Emre Kara , Betul Okuyan , Cansu Goncuoglu , Kutay Demirkan , Shusen Sun

Background

The role of pharmacists in emergency departments (EDs) has undergone a significant transformation globally, expanding beyond traditional responsibilities to include various clinical activities that promise to enhance patient outcomes. However, the full potential of these interventions, particularly from economic, clinical, and humanistic (ECHO) perspectives, remains to be systematically explored. The aim of this study was to evaluate the impact of pharmacist-led interventions on ECHO among patients admitted to the ED.

Methods

This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searches were conducted in PubMed, MEDLINE, and International Pharmaceutical Abstracts, focusing on randomized controlled trials (RCTs) published in English that involved pharmacist interventions in EDs. Data were extracted on study design, pharmacist interventions, and patient outcomes. Cochrane risk-of-bias tool for randomized trials (RoB 2.0) was used.

Results

Twelve RCTs that met the inclusion criteria were identified. The studies were conducted predominantly in tertiary care settings in various countries. The most common interventions performed by pharmacists included medication reconciliation, obtaining medication histories, and patient education. The review showed that pharmacist interventions tend to improve medication safety and patient satisfaction but varied significantly in their execution and reported outcomes. No studies comprehensively analyzed economic outcomes, and only a few addressed humanistic outcomes.

Conclusions

Pharmacy-led services improved clinical outcomes, however there was lack of studies showing the economic and humanistic outcomes of these services. The need for standardized protocols and further research to establish their broader impacts should be considered. The findings support the continued integration and expansion of pharmacist roles in emergency care, which could influence global policy and practice in healthcare systems.
在全球范围内,急诊科(ed)药剂师的角色经历了重大转变,超越了传统的职责,包括各种有望提高患者预后的临床活动。然而,这些干预措施的全部潜力,特别是从经济、临床和人文(ECHO)的角度来看,仍有待系统地探索。本研究的目的是评估药剂师主导的干预措施对ed住院患者的ECHO的影响。方法本系统评价按照系统评价和荟萃分析(PRISMA)指南的首选报告项目进行。我们在PubMed、MEDLINE和国际药学文摘中进行了检索,重点是随机对照试验(RCTs),这些试验用英文发表,涉及药剂师对急诊科的干预。我们提取了研究设计、药剂师干预和患者预后方面的数据。采用Cochrane随机试验风险偏倚工具(RoB 2.0)。结果共纳入12项符合纳入标准的随机对照试验。这些研究主要是在各国的三级保健机构进行的。药剂师最常见的干预措施包括药物和解、获取用药史和患者教育。回顾显示,药师干预倾向于提高用药安全性和患者满意度,但在执行和报告结果方面差异显着。没有研究全面分析经济成果,只有少数研究涉及人文成果。结论以药房为主导的服务改善了临床结果,但缺乏研究显示这些服务的经济和人文效果。应考虑是否需要标准化的协议和进一步研究以确定其更广泛的影响。研究结果支持药剂师在急诊护理中的持续整合和扩大作用,这可能影响全球卫生保健系统的政策和实践。
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引用次数: 0
Evaluation of the Aged Care On-site Pharmacist (ACOP) program in Australian residential aged care homes: Key considerations and next steps 澳大利亚老年护理院老年护理现场药剂师(ACOP)计划的评估:关键考虑因素和下一步
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-10-14 DOI: 10.1016/j.sapharm.2025.10.006
Janet K. Sluggett , Daria S. Gutteridge , Annabel Calder , Georgina A. Hughes , Elizabeth Manias , Shanthi A. Ramanathan , Kurtis Budden , Ingrid Sketris , Sara Javanparast
Older people who live in residential aged care homes (RACHs) often experience polypharmacy and use potentially inappropriate medications. In response to issues identified by a recent national inquiry that identified the need to improve medication management practices in Australian RACHs, a federal government-subsidized initiative to enable clinical pharmacists to practice on-site in Australian RACHs has recently been launched. This new optional program has been funded to enhance quality use of medicines and resident's health and wellbeing in Australian RACHs. This commentary discusses the need for a comprehensive evaluation of this population-based and publicly subsidized initiative to improve medication management in RACHs. It presents a program logic model that outlines the required activities, key outputs and anticipated impacts of Australia's RACH on-site pharmacist program to aid program implementers and beneficiaries to plan, communicate, and evaluate this new program. The program logic model presented can also inform the actions of policy makers and program implementers in other countries who are involved in planning, execution and evaluation of new pharmacist-led interventions or programs in RACHs.
居住在养老院(RACHs)的老年人经常使用多种药物,并可能使用不适当的药物。最近,一项全国性的调查发现,需要改善澳大利亚乡村医院的药物管理实践,为了应对这一问题,联邦政府资助了一项倡议,使临床药剂师能够在澳大利亚乡村医院现场执业。这项新的可选方案已获得资助,以提高澳大利亚地区药品的使用质量和居民的健康和福祉。本评论讨论了对这一以人群为基础的公共补贴倡议进行全面评估的必要性,以改善乡村地区的药物管理。它提出了一个项目逻辑模型,概述了澳大利亚RACH现场药剂师项目所需的活动、主要产出和预期影响,以帮助项目实施者和受益者计划、沟通和评估这个新项目。所提出的项目逻辑模型也可以为其他国家的政策制定者和项目实施者的行动提供参考,这些国家和地区的政策制定者和项目实施者参与了新药剂师主导的干预措施或项目的规划、执行和评估。
{"title":"Evaluation of the Aged Care On-site Pharmacist (ACOP) program in Australian residential aged care homes: Key considerations and next steps","authors":"Janet K. Sluggett ,&nbsp;Daria S. Gutteridge ,&nbsp;Annabel Calder ,&nbsp;Georgina A. Hughes ,&nbsp;Elizabeth Manias ,&nbsp;Shanthi A. Ramanathan ,&nbsp;Kurtis Budden ,&nbsp;Ingrid Sketris ,&nbsp;Sara Javanparast","doi":"10.1016/j.sapharm.2025.10.006","DOIUrl":"10.1016/j.sapharm.2025.10.006","url":null,"abstract":"<div><div>Older people who live in residential aged care homes (RACHs) often experience polypharmacy and use potentially inappropriate medications. In response to issues identified by a recent national inquiry that identified the need to improve medication management practices in Australian RACHs, a federal government-subsidized initiative to enable clinical pharmacists to practice on-site in Australian RACHs has recently been launched. This new optional program has been funded to enhance quality use of medicines and resident's health and wellbeing in Australian RACHs. This commentary discusses the need for a comprehensive evaluation of this population-based and publicly subsidized initiative to improve medication management in RACHs. It presents a program logic model that outlines the required activities, key outputs and anticipated impacts of Australia's RACH on-site pharmacist program to aid program implementers and beneficiaries to plan, communicate, and evaluate this new program. The program logic model presented can also inform the actions of policy makers and program implementers in other countries who are involved in planning, execution and evaluation of new pharmacist-led interventions or programs in RACHs.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"22 2","pages":"Pages 348-353"},"PeriodicalIF":2.8,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145929328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Research in Social & Administrative Pharmacy
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