Research in Social & Administrative Pharmacy最新文献

{"title":"Insights into community pharmacists’ behavioural intention towards providing safe medication disposal service using the theory of planned behaviour","authors":"Sheng Yuan Hiew ,&nbsp;Bee Yean Low ,&nbsp;Kian Wah Liew ,&nbsp;Wah Yun Low ,&nbsp;Kang Nee Ting ,&nbsp;Matthew Boyd","doi":"10.1016/j.sapharm.2025.06.111","DOIUrl":"10.1016/j.sapharm.2025.06.111","url":null,"abstract":"<div><h3>Background</h3><div>Household pharmaceutical waste disposal in Malaysia is inadequate, largely due to limited awareness and a lack of safe disposal facilities. Community pharmacies are not legally required to collect unused or expired medications and face various challenges in offering disposal services. Therefore, it is essential to investigate the factors influencing community pharmacists’ intention to provide safe medication disposal.</div></div><div><h3>Objectives</h3><div>This study aims to identify the attitude, subjective norm and perceived behavioural control affecting Malaysian community pharmacists’ intention to provide medication take-back service and to identify the predictors of this intention.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was conducted with a stratified random sample of 424 community pharmacists in the Klang Valley. The Theory of Planned Behaviour (TPB) served as the theoretical framework, with constructs measured using a 4-point Likert scale. Partial Least Squares Structural Equation Modeling (PLS-SEM) was used to analyse how TPB constructs and external factors influence pharmacists' intention.</div></div><div><h3>Results</h3><div>Of the 424 surveys, 310 responses were received (response rate: 73.1 %). The PLS-SEM model explained 66 % of the variance in pharmacists' intention (R² = 0.662, adjusted R² = 0.656). While attitude was not a significant predictor, subjective norm e.g. patient demand and external factors e.g. business competitiveness were significant positive predictors. Conversely, perceived behavioural control factors, including workload, costs, space and authority negatively impacted intention.</div></div><div><h3>Conclusions</h3><div>This study identifies key constructs influencing community pharmacists' intention to offer medication take-back service. A multifaceted approach involving clear regulatory frameworks, government support and pharmaceutical industry participation, and public education is necessary to enhance this intention.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 1059-1069"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing pharmaceutical practice: Promoting organizational health literacy to improve medication use through an intersectoral model based on the preventive medicine framework","authors":"Francisco Javier Ferreira-Alfaya,&nbsp;Yasmin Cura,&nbsp;María José Zarzuelo-Romero","doi":"10.1016/j.sapharm.2025.08.003","DOIUrl":"10.1016/j.sapharm.2025.08.003","url":null,"abstract":"<div><h3>Background</h3><div>Health Literacy remains insufficiently developed in many populations, leading to suboptimal health outcomes and increased socio-economic burden. Despite lying at the intersection of educational and healthcare sectors, Health Literacy interventions are hindered by persistent institutional disconnect. Pharmacists, due to their accessibility and expertise in medication use, are well-positioned to bridge this gap and support intersectoral strategies to improve patient outcomes.</div></div><div><h3>Objectives</h3><div>This study proposes a pharmacist-led model of Organizational Health Literacy, grounded in current recommendations and identified systemic gaps.</div></div><div><h3>Methods</h3><div>A pharmacist-led model was developed through a narrative synthesis of the literature, incorporating current recommendations, conceptual frameworks, and identified gaps in the implementation of Organizational Health Literacy across healthcare and educational systems. The preventive medicine model by Leavell and Clark was adapted to structure the intersectoral approach.</div></div><div><h3>Results</h3><div>The proposed model outlines four interconnected domains of pharmaceutical intervention: (1) integration of pharmacists into formal health education settings, (2) systematic assessment and support of patients' Health Literacy during pharmacy encounters, (3) outreach to vulnerable populations excluded from formal education systems, and (4) alignment of medication information with users’ actual Health Literacy levels to support rational medication use.</div></div><div><h3>Conclusions</h3><div>This proposed model underscores the transformative potential of pharmacy practice by expanding pharmacists’ roles as health educators and intersectoral communicators. By repositioning pharmacists as connectors between educational and healthcare systems, it offers a strategic framework to address systemic Health Literacy barriers and promote appropriate and informed medication use.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 1096-1105"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital educational interventions for antimicrobial stewardship: A systematic review","authors":"Michela Monaci ,&nbsp;Antonia Rake ,&nbsp;Marta Acampora ,&nbsp;Serena Barello","doi":"10.1016/j.sapharm.2025.07.003","DOIUrl":"10.1016/j.sapharm.2025.07.003","url":null,"abstract":"<div><h3>Background</h3><div>Antimicrobial Stewardship programs (ASPs) help reduce antimicrobial resistance (AMR) by promoting responsible antibiotic use. However, implementation is often inconsistent, especially in low-resource settings. Digital health technologies (DHTs) provide scalable and flexible means to enhance ASPs, particularly through targeted educational interventions for clinicians, students, and the public.</div></div><div><h3>Aim</h3><div>This systematic review aimed to evaluate the effectiveness of digital educational within ASPs by enhancing knowledge and driving behavior change, with a specific focus on the educational strategies employed, their theoretical underpinnings, and their differential impact across populations and settings.</div></div><div><h3>Method</h3><div>This review followed PRISMA and Joanna Briggs Institute (JBI) guidelines, with a protocol registered in PROSPERO. A comprehensive search of four databases (PubMed, Web of Science, Scopus, and CINAHL) was conducted to identify primary peer-reviewed studies published in English that quantitatively evaluated digital educational ASPs. Risk of bias was assessed using standardized appraisal tools.</div></div><div><h3>Results</h3><div>Twenty-three studies, conducted in diverse contexts and targeting different stakeholders, were included in the review. All interventions reported positive impacts on knowledge enhancement and behavior change. Engagement-driven approaches, such as interactive modules, real-time feedback, and case-based simulations, were most common, and strategies were tailored to the specific target groups. However, theoretical underpinnings were rarely reported, with only two studies explicitly grounded in behavior change theory. Few studies included long-term follow-up assessments, and most lacked rigorous designs such as randomization. Risk of bias was assessed and varied across studies. The interventions varied widely in duration, frequency, and delivery format, limiting comparability.</div></div><div><h3>Conclusion</h3><div>Digital educational ASPs show strong promise in improving knowledge and driving behavior change across a wide range of settings and stakeholder groups. Their adaptability, scalability, and user-centered design underscore their potential as valuable tools in the global effort to combat antimicrobial resistance. To maximize their long-term impact, future interventions should be informed by behavioral theory, include follow-up beyond six months, and address contextual needs in low-resource settings.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 991-1012"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New program theory in pharmacist-led patient-centered medication review in general practice: A qualitative pilot study","authors":"Susanne Kaae ,&nbsp;Sara Sommer Holst ,&nbsp;Johanne Mølby Hansen ,&nbsp;Charlotte Vermehren","doi":"10.1016/j.sapharm.2025.07.002","DOIUrl":"10.1016/j.sapharm.2025.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Pharmacists are increasingly engaged in general practice to contribute to rational prescribing and to reduce the workloads. To further improve patients' outcomes, a new <em>patient-centered</em> medication review (MR) model in primary care for polypharmacy patients was developed. This model involves patients in an initial ‘problem detection meeting’ with the pharmacist and in a meeting with the pharmacist and the General Practitioner (GP) to discuss MR findings.</div></div><div><h3>Objectives</h3><div>To pilot test the new MR model to supplement existing program theory.</div></div><div><h3>Methods</h3><div>Qualitative descriptive nonparticipatory observations of the MR model were carried out in two general practices in Denmark to identify Context elements and determine how the Intervention was enacted. Semistructured interviews with GPs, patients and the pharmacist were conducted to establish Outcomes. Through principles of realist evaluation, Mechanisms, i.e., links connecting Context, Intervention and Outcomes, were inferred.</div></div><div><h3>Results</h3><div>The new model led to satisfaction among patients and GPs. Three central mechanisms were: 1) alignment between the pharmacist and the GP in their understanding of MR work; 2) investment in relational work; and 3) flexibility, allowing the model to fulfill the needs of GPs despite differences in experiences with polypharmacy, working styles, and knowledge of enrolled patients.</div></div><div><h3>Conclusion</h3><div>The new model illustrates how pharmacists can support GPs. New program theory regards the importance of compatible perspectives between pharmacists and GPs on appropriate polypharmacy work, i.e., ‘shared mental models’, the ways GPs can develop their mental models when interacting with pharmacists, and the usefulness of relational work when the models clash.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 1070-1078"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of medication therapy management on medication adherence and health-related quality of life among non-dialysis chronic kidney disease patients","authors":"Shivaprasad Sirimalla ,&nbsp;Uday Venkat Mateti ,&nbsp;Pradeep Shenoy ,&nbsp;C.S. Shastry ,&nbsp;Shraddha Shetty","doi":"10.1016/j.sapharm.2025.08.002","DOIUrl":"10.1016/j.sapharm.2025.08.002","url":null,"abstract":"<div><h3>Background</h3><div>Chronic kidney disease (CKD) is a progressive disease, often associated with poor medication adherence and reduced health related quality of life (HRQoL). Medication therapy management (MTM) is a range of services provided to patients and has been shown to enhance medication adherence and HRQoL, yet its impact on non-dialysis CKD patients remains underexplored. So, the study was aimed to see the impact of MTM on medication adherence and HRQoL among non-dialysis CKD patients.</div></div><div><h3>Methodology</h3><div>The prospective, open-labelled randomization-controlled study was conducted among CKD non-dialysis patients. HRQoL was assessed using KDQoL-36 questionnaire. Medication adherence was assessed using the medication adherence scale. Both were assessed at baseline; 6^th and 12^th month follow up. MTM group received clinical pharmacist's MTM services along with usual care (UC). UC group received the hospital team's general care from the Doctors, Nurses, and other health care professionals.</div></div><div><h3>Results</h3><div>A total of 220 CKD patients has been enrolled into the both groups in 1:1 ratio. At baseline, most of the patients were having medium adherence in both MTM 82 (74.54) and UC 77 (70) groups, followed by low adherence with p value 0.131. At 6^th and 12^th month follow-up. Medication adherence was increased in the MTM group compared to the UC group with p value &lt;0.001. In the baseline, the more HRQoL score was found in the domain \"symptoms and problems list\" in both MTM 70.4 and UC groups 71.5 with the p value &gt;0.05. The HRQoL scores of 5 domains were significantly increased at the 6th month and 12th month in the MTM group compared to the UC group with p value &lt;0.05.</div></div><div><h3>Conclusion</h3><div>Study concluded, MTM services increased the medication adherence and HR-QoL of CKD non dialysis patients in MTM group compared to UC group. In future, MTM services can be implemented in healthcare settings.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 1090-1095"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacists’ barriers and enablers to delivering health behaviour recommendations for patients with behavioural determinants of disease: Application of the COM-B model","authors":"Chloe Maxwell-Smith ,&nbsp;Hayley Breare ,&nbsp;Alejandro Dominguez Garcia ,&nbsp;Tin Fei Sim ,&nbsp;Krysten Blackford ,&nbsp;Barbara A. Mullan","doi":"10.1016/j.sapharm.2025.07.004","DOIUrl":"10.1016/j.sapharm.2025.07.004","url":null,"abstract":"<div><h3>Background</h3><div>Pharmacists are among the most trusted and accessible health professionals in Australia. Community pharmacists are well positioned to deliver brief health recommendations to reduce risk factors of communicable and non-communicable disease during patient interactions. However, effective facilitation of these interactions in pharmacy practice should be considered. The Capability, Opportunity, Motivation and Behaviour (COM-B) model provides a framework to map understanding of the factors affecting pharmacists’ delivery of health behaviour recommendations to patients, with the aim of reducing disease risk factors.</div></div><div><h3>Methods</h3><div>Thirteen semi-structured interviews were conducted with Australian community pharmacists (<em>M</em>_<em>age</em> = 38.7 years, <em>SD</em> = 15.6). Participants described their barriers and enablers to delivering brief health behaviour change recommendations during patient counselling. Transcripts were analysed using reflexive thematic analysis, with the COM-B model as a guiding framework.</div></div><div><h3>Results</h3><div>Three themes were identified: ‘<em>Perceptions of patient willingness’, ‘Professional Role and Identity’,</em> and <em>‘Structural constraints in pharmacy practice</em>.<em>’</em> Pharmacists reported being motivated to engage with patients about behaviour change but felt inhibited by retail-models of pharmacy, time constraints, and lack of experiential learning. A patient-centred pharmacy model, theoretical knowledge of behaviour change, proprietor support, and patient interest appeared to be instrumental in the effective facilitation of behaviour change advice.</div></div><div><h3>Discussion</h3><div>Pharmacists are reportedly motivated to engage with patients about health risk factors and disease management. However, external barriers to recommendations and lack of time may only be reduced with management support. Findings necessitate pharmacy model-level initiatives to effectively overcome barriers, such as educating pharmacists about the benefits of behavioural medicine, and training in brief behaviour change techniques through professional development opportunities. Behavioural medicine can enhance pharmacists’ capacity to support individuals in managing chronic and communicable disease, but this may need to be incorporated and prioritised early in pharmacy training, including throughout tertiary pharmacy curricula.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 1079-1089"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mentorship in entry-to-practice pharmacy programs: A scoping review","authors":"Emelith Cerbito ,&nbsp;Abrar Abdelrahman ,&nbsp;Safa Tahar,&nbsp;Baleegh Abdulmajeed,&nbsp;Alla El-Awaisi","doi":"10.1016/j.sapharm.2025.07.006","DOIUrl":"10.1016/j.sapharm.2025.07.006","url":null,"abstract":"<div><h3>Background</h3><div>Mentorship is a well-established educational strategy with demonstrated benefits across health professions education, including pharmacy. However, there remains paucity with regards to understanding mentorship in entry-to-practice pharmacy programs. This scoping review aims to identify and describe mentorship models used in mentoring pharmacy students in entry-level pharmacy, outcomes, characteristics of an effective mentorship, and gaps in current literature on mentorship in pharmacy.</div></div><div><h3>Methods</h3><div>A systematic literature search was initially conducted in early 2022 across PubMed, Embase, EBSCO, and Scopus, using a combination of keywords and MeSH terms related to mentorship in entry-level pharmacy education. The search was updated in May 2025 to include studies published between 2022 and 2024. Two independent reviewers screened all titles, abstracts, and full texts. Data were extracted on study characteristics and outcome's, and findings were synthesized using Hamlin and Sage's conceptual framework for effective mentoring.</div></div><div><h3>Results</h3><div>Out of the 1726 identified records, 25 studies met the inclusion criteria. Most were conducted in the United States (80 %, n = 20). Most studies aimed to assess the impact of mentorship on mentees' attitude and development. Several studies incorporated traditional mentoring (n = 8), group mentoring (n = 5), hybrid mentoring (n = 7), and peer mentoring (n = 3). Five recurring elements were found to support effective mentorship in pharmacy programs robust recruitment process and training, clear goals, effective communication, mentor-mentee matching, and regular feedback/evaluation.</div></div><div><h3>Conclusion</h3><div>Mentorship is a valuable component of pharmacy education, with demonstrated benefits for both mentees and mentors. The findings highlight the need for structured mentorship frameworks, standardized evaluation tools, and greater global representation in future research. Implementing evidence-informed mentorship programs may support student success and contribute to the advancement of the pharmacy profession.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 1024-1041"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritising tool(s) for measuring chronic pain-related outcomes as part of the pharmacotherapy service in Scotland: a patient consensus study","authors":"Aimee Denver-Wason,&nbsp;Emma Dunlop,&nbsp;Natalie Weir,&nbsp;Marion Bennie","doi":"10.1016/j.sapharm.2025.06.004","DOIUrl":"10.1016/j.sapharm.2025.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Pharmacist-led pharmacotherapy services in Scotland play a crucial role in managing people's chronic pain. Exploring patient preferences regarding pain-specific and quality of life assessment tools is essential for delivering patient-centred care. However, the current evidence base remains limited.</div></div><div><h3>Objectives</h3><div>To obtain patient consensus on their preferred tools appropriate for measuring chronic pain outcomes as part of the pharmacist-led pharmacotherapy service in Scotland; and to obtain patient perspectives on the interpretability, comprehensibility and accessibility of tool(s).</div></div><div><h3>Methods</h3><div>A predominantly convenience sampling strategy recruited patients with experience of chronic pain in Scotland. An online modified nominal group technique (NGT) was conducted. This involved reviewing five outcomes tools, round robin feedback, discussions, ranking, and a final consensus exercise. Ranking results were used to identify the most preferable tool for use in practice. Discussions throughout the NGT were thematically analysed to explore the comprehensibility, interpretability, and accessibility of the tools.</div></div><div><h3>Result</h3><div>Seven patients participated, from 6 of 14 Scottish health boards. Consensus identified the Brief Pain Inventory as the most preferable tool, with the EQ-5D-5L and Short-Form McGill Pain Questionnaire ranked joint second. Thematic analysis highlighted key areas for consideration related to tool comprehensibility and fundamental concepts surrounding the definition of pain and the subjectivity of the language used in tools. General comments included the importance of digital accessibility, and preferences around pain-specific vs HRQoL tools.</div></div><div><h3>Conclusions</h3><div>The findings will facilitate decision making regarding the delivery of pharmacotherapy chronic pain services in Scotland. There is a preference for a disease-specific tool, however a combination of the BPI and the more general EQ-5D-5L could be used to capture more insight into the impact of the service on patients. Future work should test these tools in diverse populations and explore the use of the EQ-5D-5L with condition-specific tools for patients with various chronic conditions.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 1050-1058"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence and persistence to heart failure guideline-directed medical therapy: A systematic review of studies based on electronic healthcare data","authors":"Nerea Báez-Gutiérrez ,&nbsp;Cristina Galindo-García ,&nbsp;Héctor Rodríguez-Ramallo ,&nbsp;Susana Sánchez-Fidalgo","doi":"10.1016/j.sapharm.2025.07.005","DOIUrl":"10.1016/j.sapharm.2025.07.005","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure (HF) significantly impacts global morbidity, mortality, and healthcare costs. Effective treatment involves multiple guideline-directed medical therapies, such as beta-blockers, angiotensin-converting enzyme inhibitors, and mineralocorticoid receptor antagonists, angiotensin receptor–neprilysin inhibitor and sodium-glucose cotransporter 2 inhibitors. However, medication adherence and persistence in HF patients are often suboptimal, negatively influencing clinical outcomes. This systematic review assesses medication adherence and persistence among HF patients and their relationship to clinical outcomes.</div></div><div><h3>Methods</h3><div>A systematic review following PRISMA guidelines was conducted, evaluating observational studies utilizing electronic healthcare databases published between 1990 and 2024. Studies reporting adherence or persistence to HF pharmacological treatments, measured by pharmacy claims or electronic health records, were included. Primary adherence (initial dispensing), secondary adherence (continued refilling), and persistence (duration until medication discontinuation) were analyzed.</div></div><div><h3>Results</h3><div>Fifty-two studies involving 2,001,178 HF patients were reviewed. No studies adequately assessed primary adherence. Secondary adherence was predominantly evaluated using Proportion of Days Covered or Medication Possession Ratio, with adherence generally below optimal levels (&lt;80 %). Medication adherence declined significantly with increased regimen complexity and over extended periods. Persistence rates were notably lower in long-term follow-ups, especially with mineralocorticoid receptor antagonists. Higher medication adherence and persistence consistently correlated with reduced hospitalizations, emergency department visits, and mortality rates. Methodological heterogeneity across studies precluded the feasibility of a meta-analysis.</div></div><div><h3>Conclusions</h3><div>Medication adherence and persistence among HF patients remain suboptimal, particularly with complex, multi-drug regimens and prolonged treatments. Improved adherence was correlated with better clinical outcomes, underscoring the need for standardized adherence measures and targeted interventions to enhance patient outcomes.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 12","pages":"Pages 1013-1023"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Belief Profiles and Nonadherence to Oral Anticancer Medication in Cancer Survivors: A Latent Profile Analysis","authors":"Meng-Jung Wen ,&nbsp;Olayinka Shiyanbola","doi":"10.1016/j.sapharm.2025.03.020","DOIUrl":"10.1016/j.sapharm.2025.03.020","url":null,"abstract":"","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"21 11","pages":"Page e29"},"PeriodicalIF":2.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}