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Factors related to medication adherence among people experiencing homelessness 无家可归者中与药物依从性相关的因素。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1016/j.sapharm.2025.12.005
James O. Baffoe , Leticia R. Moczygemba , Anton L.V. Avanceña , Carolyn M. Brown , Emily M. Seales

Background

Medication adherence among people experiencing homelessness (PEH) is consistently low. There is limited research investigating the factors related to adherence in PEH.

Objective

To describe and examine the relationship between traditional and vulnerable predisposing, enabling, and need (PEN) factors and medication adherence among PEH.

Methods

A cross-sectional survey was conducted at two homeless services agencies in central Texas, from June to August 2024. PEH who were at least 18 years old, took at least one oral prescription for a chronic condition, used the healthcare system in the past six months, and communicated in English were eligible. The dependent variable, medication adherence, was measured using the nine-item Hill-Bone Medication Adherence Scale (1 = all of the time to 4 = none of the time), range 9 – 36; higher scores indicated higher adherence. The independent variables were the traditional and vulnerable PEN factors. Data analysis included descriptive, bivariate, and linear regression analyses.

Results

Participants (n = 150) were 49.0 (± 10.8) years old and were homeless for 5.0 (± 6.0) years. Most were male (72.0%), half (50.0%) were White, and a quarter (25.3%) were Hispanic. The mean adherence score was 29.6 ± 4.4/36, where 4.4 represents the standard deviation (SD). Substance use, psychological distress, affordability of medications, access to transportation, access to medication storage, competing needs/priorities, and number of medications were related to medication adherence (p < 0.05) in the bivariate analyses. After adjusting for independent variables, psychological distress (p = 0.0025) and medication affordability (p = 0.0055) were associated with medication adherence.

Conclusion

Healthcare professionals can consider tailoring medication adherence counseling to focus on strategies to mitigate psychological distress and medication affordability challenges.
背景:无家可归者(PEH)的药物依从性一直很低。关于PEH依从性相关因素的研究有限。目的:描述和研究PEH中传统易感因素、使能因素和需要因素与药物依从性的关系。方法:于2024年6月至8月在德克萨斯州中部的两家无家可归者服务机构进行横断面调查。年满18岁,至少服用过一种慢性疾病口服处方,在过去6个月内使用过医疗保健系统,并以英语沟通的PEH符合条件。因变量药物依从性采用9项Hill-Bone药物依从性量表(1 =所有时间至4 =没有时间)测量,范围为9 - 36;得分越高表明依从性越高。自变量为传统因子和易感因子。数据分析包括描述性、双变量和线性回归分析。结果:参与者(n = 150)年龄49.0(±10.8)岁,无家可归5.0(±6.0)年。大多数是男性(72.0%),一半(50.0%)是白人,四分之一(25.3%)是西班牙裔。平均依从性评分为29.6±4.4/36,其中4.4为标准差(SD)。药物使用、心理困扰、药物的可负担性、交通工具的可及性、药物储存的可及性、竞争需求/优先级和药物数量与药物依从性相关(p结论:医疗保健专业人员可以考虑定制药物依从性咨询,以关注减轻心理困扰和药物可负担性挑战的策略。
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引用次数: 0
Pharmacy technicians in Europe: exploring the diversity in training, roles, and regulation 欧洲的药学技术人员:探索培训、角色和监管的多样性。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-12-04 DOI: 10.1016/j.sapharm.2025.12.001
Carolina Valeiro , Vitor Silva , Ângelo Jesus , João Joaquim , Cristiano Matos

Background

Pharmacy technicians are increasingly recognized as essential healthcare professionals who contribute significantly to the delivery of pharmacy services. However, in Europe, the education, training, and regulatory frameworks governing pharmacy technicians vary substantially, influencing their scope of practice and integration within healthcare systems.

Objective

This review maps the education, qualifications, and scope of practice of PTs across Europe, highlighting differences in professional titles and regulatory approaches.

Methods

A review was conducted using publicly available data from the EU Regulated Professions Database and data collected from national organizations representing pharmacy technicians across Europe. Data on professional titles, qualification levels, regulations, program duration, and role delineation were extracted and summarized for comparison.

Results

Findings from 28 European countries revealed significant variability in pharmacy technician qualification levels (EQF 4–6), training duration (2–4.5 years), and national regulation. Regulation ranges from mandatory licensing with protected titles to a lack of regulation. The scope of practice differs, from basic dispensing and inventory tasks to broader clinical and technical responsibilities.

Conclusion

The landscape of pharmacy technician education and regulation in Europe remains fragmented. Although PTs share core responsibilities, qualification levels, program durations, and regulatory protections vary widely, limiting professional identity, mobility, and workforce planning. Developing a shared European framework for education and professional recognition could facilitate professional mobility, reduce professional and skill disparities, and support safe, high-quality pharmacy services, ultimately optimizing the contribution of PTs to healthcare systems.
背景:药学技术人员越来越被认为是重要的医疗保健专业人员,他们对药学服务的提供做出了重大贡献。然而,在欧洲,管理药学技术人员的教育、培训和监管框架差异很大,影响了他们在医疗保健系统中的实践范围和整合。目的:本综述描绘了整个欧洲PTs的教育、资格和执业范围,突出了职称和监管方法的差异。方法:使用来自欧盟监管专业数据库的公开数据和来自代表欧洲药学技术人员的国家组织的数据进行回顾。对职称、资格等级、法规、项目持续时间和角色描述的数据进行提取和总结,以进行比较。结果:来自28个欧洲国家的调查结果显示,在药学技术人员资格水平(EQF 4-6)、培训时间(2-4.5年)和国家法规方面存在显著差异。监管范围从带有受保护标题的强制许可到缺乏监管。实践范围有所不同,从基本的配药和库存任务到更广泛的临床和技术责任。结论:欧洲药学技术人员的教育和监管格局仍然分散。尽管专业技术人员共同承担核心责任,但资格等级、项目持续时间和监管保护差异很大,限制了专业身份、流动性和劳动力规划。开发一个共享的欧洲教育和专业认可框架可以促进专业人员流动,减少专业和技能差距,并支持安全、高质量的药房服务,最终优化PTs对医疗保健系统的贡献。
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引用次数: 0
Cross-cultural adaptation of patient-reported outcome measures: Methodological guidance for a better practice 患者报告结果测量的跨文化适应:更好实践的方法学指导。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-12-05 DOI: 10.1016/j.sapharm.2025.12.002
Sundos Q. Al-Ebrahim , Jeff Harrison , Timothy F. Chen , Mohammed A. Mohammed
Literature on the development of patient-reported outcome measures (PROMs) has continue to expand over the past two decades. With the increasing global use of PROMs in research and clinical practice, there is a need for their rigorous and systematic translation and cultural adaptation to ensure appropriate use in new contexts. This requires a structured approach to ensure linguistic and cultural equivalence, the quality of cross-cultural adaptation (CCA), and psychometric properties of the adapted PROMs. Poor CCA can be a challenge to the transferability and applicability of PROMs. A reasonable approach to ensure high-quality CCA could involve selecting certified translators, reconciling feedback, conducting pilot tests with end users, forming an expert committee, and consulting with the original tool developers. However, there are gaps in how the process of CCA was applied and reported. Although numerous guidelines for CCA exist, none are regarded as a gold standard. In addition, there is a lack of consensus on the best and most effective method of translation. This methodological paper addresses these gaps by describing methodological guidance for CCA, including comprehensive, step-by-step instructions and toolkits to enhance researchers' understanding and application of the CCA process.
在过去的二十年中,关于患者报告结果测量(PROMs)发展的文献不断扩大。随着全球越来越多地在研究和临床实践中使用PROMs,需要对其进行严格和系统的翻译和文化适应,以确保在新的环境中适当使用。这需要一种结构化的方法来确保语言和文化的对等性,跨文化适应的质量(CCA),以及适应后的prom的心理测量特性。较差的CCA可能对prom的可转移性和适用性构成挑战。确保高质量CCA的合理方法包括选择经过认证的翻译人员、协调反馈、与最终用户进行试点测试、组建专家委员会以及咨询原始工具开发人员。然而,在如何应用和报告CCA过程方面存在差距。尽管存在许多CCA指导方针,但没有一个被视为黄金标准。此外,对于最佳和最有效的翻译方法也缺乏共识。这篇方法学论文通过描述CCA的方法学指导来解决这些差距,包括全面的、逐步的指导和工具包,以提高研究人员对CCA过程的理解和应用。
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引用次数: 0
Immigration timing modifies the association between medication non-adherence and cognitive function in older adults 移民时间改变了老年人药物依从性与认知功能之间的关系。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-12-01 DOI: 10.1016/j.sapharm.2025.11.011
Yuan Fang , Jayoung Han

Background

The aging U.S. immigrant population exhibits higher rates of dementia than U.S.-born residents, yet traditional diagnostic methods often fail to detect decline due to cultural and linguistic barriers. Unintentional medication non-adherence (MNA) may serve as an early, noninvasive marker of cognitive decline, but little is known about how immigration timing and other modifiers shape this relationship.

Methods

We analyzed data from 10,854 participants aged ≥65 years in the Health and Retirement Study (2012–2016). Cognitive function was assessed using standardized latent cognitive scores. Immigration status was classified as U.S.-born or immigrant, with immigrants further stratified by age at arrival (child/adolescent, early, middle, and late adulthood). Unintentional and intentional MNA were investigated separately, and a moderated moderation regression on cognitive function tested interactions between unintentional MNA, immigration status/timing, and education adjusted for demographic, socioeconomic, and health covariates.

Results

Unintentional MNA, being an immigrant (compared to non-immigrants), and older age at immigration were associated with lower cognitive scores, while higher education was protective. Significant two-way interactions indicated that immigration status (β = −0.38 ± 0.14, p = 0.0006), timing (β = −0.13 ± 0.03, p < 0.0001), and education (β = −0.09 ± 0.03, p = 0.003) moderated the MNA-cognition association, though three-way interaction was not significant. Subgroup analysis showed that unintentional MNA was generally linked to poorer cognition, but the moderating roles of immigration timing and education varied across ethnicity-immigration subgroups. The potential for residual confounding and other study limitations should be considered when interpreting these results.

Conclusion

In conclusion, unintentional MNA is a sensitive marker of cognitive decline, with risk magnified among immigrants who arrived in middle-late adulthood. Integrating adherence and immigration history into clinical assessments may improve early identification and guide targeted interventions for diverse older adults.
背景:老龄化的美国移民人口比美国出生的居民表现出更高的痴呆症发病率,然而由于文化和语言障碍,传统的诊断方法往往无法检测到衰退。无意药物依从性(MNA)可能是认知能力下降的早期、非侵入性标志,但对移民时间和其他修饰因素如何影响这种关系知之甚少。方法:我们分析了2012-2016年健康与退休研究中10854名年龄≥65岁的参与者的数据。使用标准化潜在认知评分评估认知功能。移民身份被划分为美国出生或移民,移民根据到达的年龄进一步分层(儿童/青少年,成年早期,中年和晚期)。无意MNA和有意MNA分别被调查,认知功能的适度回归测试了无意MNA、移民身份/时间和教育之间的相互作用,调整了人口、社会经济和健康协变量。结果:无意识的MNA,作为移民(与非移民相比),以及移民时年龄较大与较低的认知得分相关,而高等教育具有保护作用。结果表明,移民身份(β = -0.38±0.14,p = 0.0006)、移民时间(β = -0.13±0.03,p)是认知能力下降的敏感标志,且在成年中后期移民中风险放大。将依从性和移民史纳入临床评估可以改善早期识别并指导针对不同老年人的有针对性的干预措施。
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引用次数: 0
For a more comprehensive view of organizational culture in implementation research 为了在实施研究中更全面地了解组织文化。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-12-08 DOI: 10.1016/j.sapharm.2025.12.004
Blete Isufi , Celia Piquer-Martinez , Maria José Zarzuelo Romero , Shane P. Desselle
Organizational culture has an important role in implementation science, but unfortunately, it is often defined inconsistently or treated as a unidimensional construct, sometimes, even by equating individual perceptions of the culture with the organization, itself. This commentary advocates for a systematic, multidimensional way of defining and measuring organizational culture in implementation research, with particular attention to pharmacy practice and medication use services. Using organization theory, we describe how culture exists within a dynamic interaction between internal processes and external forces. By reviewing frameworks and empirical studies, we show that culture is multifactorial and evolves alongside implementation; it influences readiness, leadership engagement, and practice behaviors in healthcare and pharmacy settings. An example from rural community pharmacies further illustrates how cultural support for change can coexist with uneven structural capacity, underscoring the need for context-sensitive, multidimensional assessment. Research indicates that differences in how cultural dimensions are perceived within an organization can shape outcomes, suggesting that implementation strategies may need adaptation for different subgroups. Multidimensional tools like the Organizational Culture Profile and PRACTICE offer stronger approaches to assessing cultural conditions relevant to implementation. A multidimensional perspective indicates that strategies must be determined based on the cultural climate of the organization. Furthermore, sustainable change depends on assessing culture before planning and implementation, and pharmacies must continually review the internal and external cultural conditions to safeguard patient welfare.
组织文化在实施科学中扮演着重要的角色,但不幸的是,它经常被不一致地定义或视为单维结构,有时甚至将个人对文化的看法等同于组织本身。本评论主张在实施研究中采用一种系统的、多维的方法来定义和衡量组织文化,特别关注药房实践和药物使用服务。利用组织理论,我们描述了文化如何存在于内部过程和外部力量之间的动态相互作用中。通过回顾框架和实证研究,我们发现文化是多因素的,并随着实施而发展;它影响准备,领导参与,并在医疗保健和药房设置实践行为。农村社区药房的一个例子进一步说明了文化对变革的支持如何与不平衡的结构能力共存,强调了对环境敏感的多维评估的必要性。研究表明,组织内部对文化维度的感知方式的差异会影响结果,这表明实施策略可能需要针对不同的子群体进行调整。组织文化概况和实践等多维工具为评估与实施相关的文化条件提供了更强有力的方法。多维视角表明,战略必须根据组织的文化气候来确定。此外,可持续的变化取决于在计划和实施之前对文化进行评估,药店必须不断审查内部和外部文化条件,以保障患者的福利。
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引用次数: 0
A community pharmacy vaccination nudge intervention: Final results of a nationwide study 社区药房疫苗轻推干预:一项全国性研究的最终结果。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-11-28 DOI: 10.1016/j.sapharm.2025.11.010
Kenneth C. Hohmeier , Andrea Brookhart , Olivia Kinney , Kayla Dillon , Chi-Yang Chiu , Kelsey D. Frederick , Tracy Hagemann , Sujith Ramachandran , Justin Gatwood
<div><h3>Background</h3><div>Community pharmacy is involved in an increasing number of clinical services, although this has been hindered by barriers related to workload and workflow. Borrowing from theories in behavioral economics, “nudges” aim to influence behavior through non-conscious decisions. One large area of potential impact for “nudge” theory is provider-facing screening and recommendations for vaccinations, but the manner in which these mechanisms have been adopted over time is not well understood. To date no evidence exists on the effectiveness of these “nudges” in the community pharmacy setting.</div></div><div><h3>Objective</h3><div>The objective of this study is to report on final results of a pharmacist-targeted behavioral “nudge” to improve second dose completion rates for herpes zoster (HZ) vaccination. A secondary objective was to explore pharmacist acceptance of the nudge-based intervention.</div></div><div><h3>Methods</h3><div>A multi-methods approach was used to assess this quality improvement exercise in a large community pharmacy chain, including vaccine uptake counts and semi-structured interviews with community pharmacists. Changes in second-dose completion of a two-dose HZ vaccine were abstracted from the pharmacy dispensing system and assessed over 17 months once the clinical decision support (CDS) intervention became active. The qualitative arm of the project involved semi-structured, in-depth telephone interviews with pharmacists. Qualitative data was assessed using the Consolidated Framework for Implementation Research (CFIR) to assess contextual barriers and enablers to the intervention. Linear trend analysis examined both series completion and dosing intervals over the observation period.</div></div><div><h3>Results</h3><div>Thirty-six states were represented across 2271 pharmacies. Despite initial declines in completion percentages and increases in the vaccine dosing windows once the CDS system was implemented, overall improvements in both measures were realized over the course of the observation period (p < 0.01 for completion percentage trend; p < 0.001 for linear trend in mean inter-dose window). Themes derived from a total of 12 in-depth interviews included that the “nudge” positively impacted pharmacist performance expectancy, facilitated patient screening and recommendation process, integrated seamlessly into existing clinical workflows, and social influence positively impacted acceptance of “nudge.”</div></div><div><h3>Conclusion</h3><div>Community pharmacies may further their impact on public health via the use of “nudges” and other clinical decision support tools to support workflow integration. Pharmacists generally regard such interventions positively given their desire to provide more clinical services but not having adequate time to screen patients within workflow. To engage community pharmacies future research should identify means for technology to overcome workload constraints, such as “nudg
背景:社区药房参与了越来越多的临床服务,尽管这一直受到与工作量和工作流程相关的障碍的阻碍。“轻推”借用行为经济学理论,旨在通过无意识的决策影响行为。“助推”理论潜在影响的一个大领域是面向提供者的疫苗筛查和建议,但这些机制长期以来采用的方式尚未得到很好的理解。迄今为止,没有证据表明这些“推动”在社区药房环境中的有效性。目的:本研究的目的是报告以药剂师为目标的行为“推动”的最终结果,以提高带状疱疹(HZ)疫苗接种的第二剂完成率。第二个目标是探索药剂师对轻推干预的接受程度。方法:采用多方法评估大型社区连锁药店的质量改进工作,包括疫苗接种计数和对社区药剂师的半结构化访谈。从药房配药系统中提取两剂HZ疫苗的第二剂完成情况的变化,并在临床决策支持(CDS)干预开始后的17个月内进行评估。该项目的定性部分包括对药剂师进行半结构化、深入的电话采访。使用实施研究综合框架(CFIR)对定性数据进行评估,以评估干预的背景障碍和促成因素。线性趋势分析检查了整个观察期的系列完成和给药间隔。结果:有36个州的2271家药店。尽管实施CDS系统后,最初的完成率下降,疫苗剂量窗口增加,但在观察期间,这两项措施都实现了总体改善(p结论:社区药房可以通过使用“轻推”和其他临床决策支持工具来支持工作流程整合,从而进一步影响公共卫生。由于药剂师希望提供更多的临床服务,但没有足够的时间在工作流程中筛选患者,因此他们通常积极地看待这种干预措施。为了让社区药房参与进来,未来的研究应该确定技术克服工作量限制的方法,例如旨在增加筛查和依从性的“轻推”。
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引用次数: 0
Impact of pharmacist-led antibiotic stewardship audit-feedback intervention; systematic review and meta-analysis 药师主导的抗生素管理审计反馈干预的影响系统回顾和荟萃分析。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-11-24 DOI: 10.1016/j.sapharm.2025.11.002
Duaa Salem Jawhar , Amer Hayat Khan , Khurshid Alam , Rabbiya Ahmad

Background

The escalating threat of antimicrobial resistance continues to burden healthcare systems globally. Antimicrobial stewardship programs (ASPs) are recognized as a cornerstone strategy to mitigate inappropriate antibiotic use and curb resistance. Despite their growing implementation, the impact of pharmacist-led audit and feedback interventions within ASPs remains insufficiently explored.

Objective

To synthesize the evidence on the effect of pharmacist-led audit-feedback interventions within ASPs.

Methods

In accordance with PRISMA guidelines, the pooled estimate of pharmacist-led ASP audit-feedback interventions was calculated using a random-effects model. The Cochrane risk of bias tools were employed to assess the quality of the studies. We searched PubMed, SCOPUS, EBSCO/CINAHL, and Web of Science from January 1, 2000, to June 30, 2024. We included randomized controlled trials, cohort studies, case-control studies, and quasi-experimental studies. Sensitivity analyses were conducted using the leave-one-out method. Publication bias was assessed through funnel plot and Egger's regression test. Study protocol registered with PROSPERO (CRD420251036088).

Results

A total of 69,666 studies were screened, with 14 ultimately included in the final qualitative and quantitative analysis. Including 17805 patients in the pooled analysis. Pharmacist-led ASP audit-feedback intervention associated with reduction in antibiotic days of therapy, length of hospital stay (MD = −5.93, 95 % CI -12.90-1.03, I2 97.7 %), significant increase in appropriate antibiotic prescribing practice (OR 2.72, 95 % CI 1.51–4.88, I2 75 %) and 25 % reduction in mortality (OR 0.75, 95 % CI 0.55–1.03, I2 88 %)

Conclusion

This systematic review and meta-analysis provide growing evidence that pharmacist-led audit and feedback interventions within ASPs are associated with a significant improvement in appropriate antibiotic prescribing and reduction in mortality, length of hospital stay, and days of therapy. These findings support the integration of pharmacists as key leaders in ASPs and highlight the potential for policymakers to prioritize investment in pharmacist-led stewardship roles.
背景:不断升级的抗菌素耐药性威胁继续给全球卫生保健系统带来负担。抗菌药物管理规划(asp)被认为是减少抗生素不当使用和抑制耐药性的基石战略。尽管越来越多地实施,但药剂师主导的审计和反馈干预在asp中的影响仍未得到充分探索。目的:综合评价药师主导的审计反馈干预在asp中的效果。方法:根据PRISMA指南,采用随机效应模型计算药师主导的ASP审计反馈干预的汇总估计。采用Cochrane偏倚风险工具评估研究质量。我们检索了2000年1月1日至2024年6月30日期间的PubMed、SCOPUS、EBSCO/CINAHL和Web of Science。我们纳入了随机对照试验、队列研究、病例对照研究和准实验研究。采用留一法进行敏感性分析。通过漏斗图和Egger回归检验评估发表偏倚。研究方案已在PROSPERO注册(CRD420251036088)。结果:共筛选69,666项研究,其中14项最终纳入最终的定性和定量分析。共纳入17805例患者。药师主导的ASP审计反馈干预与减少抗生素治疗天数、住院时间(MD = -5.93, 95% CI -12.90-1.03, I2 97.7%)、显著增加适当的抗生素处方实践(OR 2.72, 95% CI 1.51-4.88, I2 75%)和降低25%的死亡率(OR 0.75, 95% CI 0.55-1.03, I2 88%)相关。该系统综述和荟萃分析提供了越来越多的证据,表明药师主导的asp内审计和反馈干预与适当抗生素处方的显著改善和死亡率、住院时间和治疗天数的减少有关。这些发现支持药剂师作为asp的关键领导者的整合,并强调了政策制定者优先投资药剂师领导的管理角色的潜力。
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引用次数: 0
Assessing accuracy and completeness of drug information in mobile apps compared with Micromedex®: An AI-based study in Thai online communities 与Micromedex®相比,评估移动应用程序中药物信息的准确性和完整性:一项基于人工智能的泰国在线社区研究。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-12-09 DOI: 10.1016/j.sapharm.2025.12.007
Yutthapoom Meepradist , Somchart Chokchaitam , Nuttinee Teerakulkittipong , Phakdee Sukpornsawan

Background

Ensuring access to accurate and complete drug information is fundamental to rational medication use. Mobile medical applications (MMAs) are increasingly used by healthcare providers; however, their quality compared with institutional databases remains underexplored, especially in non-English and resource-limited settings. Natural Language Processing (NLP), particularly using Thai-language transformer models such as WangchanBERTa, enables automated screening and classification of real-world drug-related queries derived from public online communities.

Objectives

This study aimed to compare the accuracy and completeness of drug information from three MMAs—Lexicomp®, Medscape®, and Epocrates®—against the institutional gold standard, Micromedex®, using AI-classified Thai-language clinical questions.

Methods

A total of 1500 Thai-language questions about drug therapy were collected from online health forums (Pharmacafe, Pantip, Reddit). Using WangchanBERTa for text classification and stratified sampling, 194 representative questions were mapped to 13 pharmacoinformatic domains. Each question was answered using the three MMAs and Micromedex®. Three licensed pharmacists independently scored each response for accuracy and completeness using a validated binary checklist (1 = correct/complete; 0 = incorrect/incomplete). Inter-rater consensus was achieved through group discussion. Accuracy and completeness were expressed as percentages and analyzed via one-way ANOVA with Tukey HSD post-hoc testing.

Results

Micromedex® demonstrated the highest accuracy (55.7 %) and completeness (53.2 %), significantly outperforming Epocrates® (p < 0.05). Among MMAs, Lexicomp® showed superior performance (accuracy = 32.3 %; completeness = 29.4 %), whereas Medscape® (accuracy = 31.6 %; completeness = 28.8 %) and Epocrates® (accuracy = 20.7 %; completeness = 18.0 %) ranked lower. The weighted composite score used previously (60 % accuracy + 40 % completeness) was removed for simplicity and clarity.

Conclusions

While Lexicomp® demonstrates potential as a practical alternative to Micromedex® in ambulatory and community-based pharmacy environments, none of the MMAs achieved equivalent reliability. Real-world Thai-language data analyzed through NLP pipelines provide a reproducible framework for pharmacoinformatic benchmarking. This approach supports rational medication use and guides digital-tool selection in low-resource healthcare systems.
背景:确保获得准确和完整的药物信息是合理用药的基础。医疗保健提供者越来越多地使用移动医疗应用程序(mma);然而,与机构数据库相比,它们的质量仍未得到充分探讨,特别是在非英语和资源有限的环境中。自然语言处理(NLP),特别是使用泰国语转换模型(如WangchanBERTa),可以自动筛选和分类来自公共在线社区的真实世界药物相关查询。目的:本研究旨在使用人工智能分类的泰语临床问题,比较三个mma - lexicomp®、Medscape®和Epocrates®-与机构金标准Micromedex®的药物信息的准确性和完整性。方法:从网上健康论坛(Pharmacafe、Pantip、Reddit)收集1500个有关药物治疗的泰语问题。使用WangchanBERTa进行文本分类和分层抽样,将194个代表性问题映射到13个药物信息学领域。每个问题都使用三个mma和Micromedex®来回答。三名执业药师使用有效的二元检查表(1 =正确/完整;0 =不正确/不完整)独立对每个回答的准确性和完整性进行评分。通过小组讨论达成了评分者之间的共识。准确性和完整性以百分比表示,并通过单因素方差分析和Tukey HSD事后检验进行分析。结果:Micromedex®显示出最高的准确性(55.7%)和完整性(53.2%),显著优于Epocrates®(p)。结论:虽然Lexicomp®显示出在门诊和社区药房环境中作为Micromedex®的实用替代品的潜力,但没有一种mma达到同等的可靠性。通过NLP管道分析的真实世界泰语数据为药物信息学基准测试提供了可重复的框架。这种方法支持合理用药,并指导低资源医疗保健系统的数字工具选择。
{"title":"Assessing accuracy and completeness of drug information in mobile apps compared with Micromedex®: An AI-based study in Thai online communities","authors":"Yutthapoom Meepradist ,&nbsp;Somchart Chokchaitam ,&nbsp;Nuttinee Teerakulkittipong ,&nbsp;Phakdee Sukpornsawan","doi":"10.1016/j.sapharm.2025.12.007","DOIUrl":"10.1016/j.sapharm.2025.12.007","url":null,"abstract":"<div><h3>Background</h3><div>Ensuring access to accurate and complete drug information is fundamental to rational medication use. Mobile medical applications (MMAs) are increasingly used by healthcare providers; however, their quality compared with institutional databases remains underexplored, especially in non-English and resource-limited settings. Natural Language Processing (NLP), particularly using Thai-language transformer models such as WangchanBERTa, enables automated screening and classification of real-world drug-related queries derived from public online communities.</div></div><div><h3>Objectives</h3><div>This study aimed to compare the accuracy and completeness of drug information from three MMAs—Lexicomp®, Medscape®, and Epocrates®—against the institutional gold standard, Micromedex®, using AI-classified Thai-language clinical questions.</div></div><div><h3>Methods</h3><div>A total of 1500 Thai-language questions about drug therapy were collected from online health forums (Pharmacafe, Pantip, Reddit). Using WangchanBERTa for text classification and stratified sampling, 194 representative questions were mapped to 13 pharmacoinformatic domains. Each question was answered using the three MMAs and Micromedex®. Three licensed pharmacists independently scored each response for accuracy and completeness using a validated binary checklist (1 = correct/complete; 0 = incorrect/incomplete). Inter-rater consensus was achieved through group discussion. Accuracy and completeness were expressed as percentages and analyzed via one-way ANOVA with Tukey HSD post-hoc testing.</div></div><div><h3>Results</h3><div>Micromedex® demonstrated the highest accuracy (55.7 %) and completeness (53.2 %), significantly outperforming Epocrates® (p &lt; 0.05). Among MMAs, Lexicomp® showed superior performance (accuracy = 32.3 %; completeness = 29.4 %), whereas Medscape® (accuracy = 31.6 %; completeness = 28.8 %) and Epocrates® (accuracy = 20.7 %; completeness = 18.0 %) ranked lower. The weighted composite score used previously (60 % accuracy + 40 % completeness) was removed for simplicity and clarity.</div></div><div><h3>Conclusions</h3><div>While Lexicomp® demonstrates potential as a practical alternative to Micromedex® in ambulatory and community-based pharmacy environments, none of the MMAs achieved equivalent reliability. Real-world Thai-language data analyzed through NLP pipelines provide a reproducible framework for pharmacoinformatic benchmarking. This approach supports rational medication use and guides digital-tool selection in low-resource healthcare systems.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"22 3","pages":"Pages 474-481"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare costs and cost determinants of minor ailments: A population-based retrospective cohort study 小病的医疗费用和费用决定因素:一项基于人群的回顾性队列研究
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-11-26 DOI: 10.1016/j.sapharm.2025.11.006
Vanessa Koo, Diedron Lewis, Mhd Wasem Alsabbagh, Nardine Nakhla, William W.L. Wong

Background

Estimating the cost of providing healthcare services for minor ailments (MA) is essential to address the impact of newly legislated pharmacist prescribing on the burden these conditions place on healthcare budgets.

Objectives

This study aims to quantify the healthcare costs associated with minor ailment management in Ontario, describe patient characteristics by cost burden, and identify predictors of high-cost encounters.

Methods

This study employed a population-based retrospective cohort design, utilizing linked health administrative data from 2011 to 2019. The cost of care, in 2019 Canadian dollars, for up to 30 days after seeing a physician for MA was estimated from the perspective of a public payer. It included expenses from inpatient or physician visits, prescribed medication and emergency department visits. A gamma regression model with a logarithmic link was used to evaluate the impact of age, sex, income, residence, and a history of comorbidities on total cost.

Results

Over 34 million cases of MA were identified during the study period, with musculoskeletal sprains and strains accounting for 23.7 % of these cases. This ailment was also the costliest ($15.8 billion). Inpatient and physician care were the most expensive services. Higher costs were associated with older population groups, males, individuals with lower incomes, those living in urban spaces, and those with comorbidities.

Conclusion

Hospital and physician-based care pose a substantial financial burden to the Ontario government. An understanding of how the determinants of cost and care pathways influence health budgets is essential to inform decisions on more efficient yet equally effective strategies, such as pharmacist prescribing for MA.
背景:估计为小病(MA)提供医疗保健服务的成本是至关重要的,以解决新立法药剂师处方的负担,这些条件对医疗保健预算的影响。目的:本研究旨在量化安大略省与小病管理相关的医疗成本,通过成本负担描述患者特征,并确定高成本遭遇的预测因素。方法:本研究采用基于人群的回顾性队列设计,利用2011年至2019年的相关卫生管理数据。从公共支付方的角度估计,在看医生治疗MA后长达30天的护理费用(以2019年加元计算)。它包括住院或医生就诊、处方药和急诊就诊的费用。采用对数回归模型评估年龄、性别、收入、居住地和合并症史对总费用的影响。结果:在研究期间发现了3400多万例MA病例,其中肌肉骨骼扭伤和劳损占23.7%。这种疾病也是最昂贵的(158亿美元)。住院和内科护理是最昂贵的服务。较高的费用与老年人群、男性、收入较低的个人、生活在城市空间的人以及患有合并症的人有关。结论:医院和以医生为基础的护理给安大略省政府带来了巨大的财政负担。了解成本和护理途径的决定因素如何影响卫生预算,对于制定更有效但同样有效的战略(如药剂师开MA处方)至关重要。
{"title":"Healthcare costs and cost determinants of minor ailments: A population-based retrospective cohort study","authors":"Vanessa Koo,&nbsp;Diedron Lewis,&nbsp;Mhd Wasem Alsabbagh,&nbsp;Nardine Nakhla,&nbsp;William W.L. Wong","doi":"10.1016/j.sapharm.2025.11.006","DOIUrl":"10.1016/j.sapharm.2025.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Estimating the cost of providing healthcare services for minor ailments (MA) is essential to address the impact of newly legislated pharmacist prescribing on the burden these conditions place on healthcare budgets.</div></div><div><h3>Objectives</h3><div>This study aims to quantify the healthcare costs associated with minor ailment management in Ontario, describe patient characteristics by cost burden, and identify predictors of high-cost encounters.</div></div><div><h3>Methods</h3><div>This study employed a population-based retrospective cohort design, utilizing linked health administrative data from 2011 to 2019. The cost of care, in 2019 Canadian dollars, for up to 30 days after seeing a physician for MA was estimated from the perspective of a public payer. It included expenses from inpatient or physician visits, prescribed medication and emergency department visits. A gamma regression model with a logarithmic link was used to evaluate the impact of age, sex, income, residence, and a history of comorbidities on total cost.</div></div><div><h3>Results</h3><div>Over 34 million cases of MA were identified during the study period, with musculoskeletal sprains and strains accounting for 23.7 % of these cases. This ailment was also the costliest ($15.8 billion). Inpatient and physician care were the most expensive services. Higher costs were associated with older population groups, males, individuals with lower incomes, those living in urban spaces, and those with comorbidities.</div></div><div><h3>Conclusion</h3><div>Hospital and physician-based care pose a substantial financial burden to the Ontario government. An understanding of how the determinants of cost and care pathways influence health budgets is essential to inform decisions on more efficient yet equally effective strategies, such as pharmacist prescribing for MA.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"22 3","pages":"Pages 425-434"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a preliminary, stakeholder-validated service framework for people with intellectual disability: Insights and limitations from a co-design study 为智障人士开发初步的利益相关者验证的服务框架:来自共同设计研究的见解和局限性。
IF 2.8 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-01 Epub Date: 2025-12-29 DOI: 10.1016/j.sapharm.2025.12.010
Chelsea Felkai , Suzanne Neilsen , Joyce Cooper , David Newby , Hayley Croft

Background

People with intellectual disability experience inequities in access to primary healthcare and pharmacists are well positioned to support this population. This study aimed to co-create a pharmacist-led primary care service framework for people with intellectual disability, grounded in participatory principles and informed by stakeholders lived experience.

Methods

Within a Participatory Action Research approach, two co-design workshops (online) were conducted with 18 stakeholders, including people with intellectual disability, carers, and health professionals, in the Newcastle/Hunter Region, Australia. A convergent qualitative approach integrated workshop transcripts, field notes, and facilitator debriefs via reflexive thematic analysis to iteratively develop and validate themes. Nominal Group Technique was used to prioritise and refine service concepts.

Results

Stakeholders co-developed a preliminary six-domain service framework: (1) Medication Management; (2) Preventative Care; (3) Monitoring and Referral; (4) Interprofessional Collaboration; (5) Communication and Education; and (6) Availability and Accessibility. Key features included structured chronic disease screening, immunisation delivery, flagging of physical challenges to prompt follow-up, shared care planning across professionals, and communication supports ensuring health literacy.

Conclusion

The participatory co-design process produced a preliminary, stakeholder-validated, multi-dimensional framework. Given the limited lived-experience representation and short duration of engagement, the framework should be considered an early prototype requiring further refinement, pilot testing, and broader validation before generalisation.
背景:智障人士在获得初级卫生保健方面经历不平等,药剂师有能力为这一人群提供支持。本研究旨在为智障人士共同创建一个以药剂师为主导的初级保健服务框架,以参与性原则为基础,并以利益相关者的生活经验为依据。方法:采用参与式行动研究方法,在澳大利亚纽卡斯尔/亨特地区与18名利益相关者(包括智障人士、护理人员和卫生专业人员)进行了两次共同设计研讨会(在线)。一种聚合的定性方法通过反思性主题分析将研讨会记录、现场记录和主持人汇报整合在一起,以迭代地开发和验证主题。使用名义组技术对服务概念进行优先排序和细化。结果:利益相关者共同开发了初步的六领域服务框架:(1)药品管理;(2)预防保健;(3)监测和转诊;(4)跨专业协作;(5)传播与教育;(6)可用性和可及性。主要特征包括结构化的慢性病筛查、免疫接种提供、身体挑战的标记以迅速跟进、专业人员之间的共享护理计划以及确保卫生素养的沟通支持。结论:参与式协同设计过程产生了一个初步的、利益相关者验证的多维框架。考虑到有限的实际经验代表和较短的参与时间,该框架应被视为早期原型,需要进一步完善、试点测试和更广泛的验证,然后才能推广。
{"title":"Developing a preliminary, stakeholder-validated service framework for people with intellectual disability: Insights and limitations from a co-design study","authors":"Chelsea Felkai ,&nbsp;Suzanne Neilsen ,&nbsp;Joyce Cooper ,&nbsp;David Newby ,&nbsp;Hayley Croft","doi":"10.1016/j.sapharm.2025.12.010","DOIUrl":"10.1016/j.sapharm.2025.12.010","url":null,"abstract":"<div><h3>Background</h3><div>People with intellectual disability experience inequities in access to primary healthcare and pharmacists are well positioned to support this population. This study aimed to co-create a pharmacist-led primary care service framework for people with intellectual disability, grounded in participatory principles and informed by stakeholders lived experience.</div></div><div><h3>Methods</h3><div>Within a Participatory Action Research approach, two co-design workshops (online) were conducted with 18 stakeholders, including people with intellectual disability, carers, and health professionals, in the Newcastle/Hunter Region, Australia. A convergent qualitative approach integrated workshop transcripts, field notes, and facilitator debriefs via reflexive thematic analysis to iteratively develop and validate themes. Nominal Group Technique was used to prioritise and refine service concepts.</div></div><div><h3>Results</h3><div>Stakeholders co-developed a preliminary six-domain service framework: (1) Medication Management; (2) Preventative Care; (3) Monitoring and Referral; (4) Interprofessional Collaboration; (5) Communication and Education; and (6) Availability and Accessibility. Key features included structured chronic disease screening, immunisation delivery, flagging of physical challenges to prompt follow-up, shared care planning across professionals, and communication supports ensuring health literacy.</div></div><div><h3>Conclusion</h3><div>The participatory co-design process produced a preliminary, stakeholder-validated, multi-dimensional framework. Given the limited lived-experience representation and short duration of engagement, the framework should be considered an early prototype requiring further refinement, pilot testing, and broader validation before generalisation.</div></div>","PeriodicalId":48126,"journal":{"name":"Research in Social & Administrative Pharmacy","volume":"22 3","pages":"Pages 491-500"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Research in Social & Administrative Pharmacy
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