Intelligent guidance applications (IGAs) have emerged with a profound impact on the patient’s experience of using healthcare services in and out of hospitals. However, the implementation of IGAs faces challenges, including low popularity and acceptance as well as uneven use of hospitals in different regions. Meanwhile, little research has examined the factors of IGAs use. To promote patient use of IGAs, this study focuses on identifying the factors of patient use of IGAs. A research model was developed to examine the factors and articulate their relationships with IGAs use based on the help-seeking model. We validated our research model through a two-stage survey and analyzed the collected data using a multi-analytical approach, including structural equation modeling (SEM) and artificial neural network (ANN). The SEM analysis results indicate that accuracy, personalization, anthropomorphism, and openness all significantly impact patients’ use intention and behavior of IGAs through distress. Self-concealment not only affects the above four attributes but also influences distress and attitudes to IGAs. Meanwhile, the impacts of both distress and attitudes to IGAs on intention to use IGAs are moderated by health consciousness. Besides, the ANN analysis results show that intention to use is the strongest predictor of IGAs use, while distress is the strongest predictor of intention to use IGAs. These findings not only provide a solid theoretical understanding of the factors of IGAs use but also have several managerial implications for hospitals and managers of IGAs to help them make effective decisions about using IGAs.
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