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Effects of a 1-year piano intervention on cognitive flexibility in older adults. 1年钢琴干预对老年人认知灵活性的影响。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-16 DOI: 10.1037/pag0000871
Melanie Mack, Damien Marie, Florian Worschech, Tillmann H C Krüger, Christopher Sinke, Eckart Altenmüller, Clara E James, Matthias Kliegel

We analyzed the data of a randomized controlled trial to examine the effects of piano practice on cognitive flexibility in healthy older adults. Participants (N = 153, 69.5 ± 3.5 years of age, 57.5% females) were randomly assigned to a piano practice group (PP) or a control group engaged in active music listening (MC). Both groups underwent a year-long intervention with weekly 60-min lessons and daily homework. We assessed switch and mixing costs in terms of speed (mean reaction times) and variability (standard deviation of reaction times) with a number switch and a perceptual switch task. We employed scale analysis based on musical instrument digital interface to assess pianistic performance. Tests were conducted at baseline, after 6 months, postintervention (12 months), and at follow-up (18 months). Results revealed more pronounced improvements in pianistic performance in the PP group compared with the MC group over the course of the intervention. Both groups exhibited gains in several cognitive flexibility outcomes, which originated primarily in the latter half of the intervention. For mixing costs of the number switch test, the PP group showed greater improvements compared with the MC group. Changes in pianistic performance were not related to changes in cognitive flexibility. Additionally, the findings indicated a compensation account in both groups, which was more pronounced in the PP group for mixing costs. This study suggests that both piano practice and active music listening-with piano practice to a higher degree-enhance cognitive flexibility, particularly in sustained control mechanisms linked to mixing costs. Both interventions potentially require longer than 6 months to induce behavioral transfer effects and are especially beneficial for individuals with lower cognitive flexibility levels. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

我们分析了一项随机对照试验的数据,以检验钢琴练习对健康老年人认知灵活性的影响。研究对象(N = 153名,年龄69.5±3.5岁,女性57.5%)随机分为钢琴练习组(PP)和积极听音乐组(MC)。两组学生都接受了为期一年的干预,每周上60分钟的课,每天做作业。我们根据速度(平均反应时间)和可变性(反应时间的标准偏差)对数字切换和感知切换任务的切换和混合成本进行了评估。我们采用基于乐器数字接口的音阶分析来评估钢琴演奏。测试分别在基线、6个月后、干预后(12个月)和随访时(18个月)进行。结果显示,与MC组相比,PP组在干预过程中钢琴表现的改善更为明显。两组在几个认知灵活性结果上都表现出了进步,这主要源于干预的后半部分。对于数字转换测试的混合成本,PP组比MC组有更大的改善。钢琴演奏的变化与认知灵活性的变化无关。此外,研究结果表明,补偿帐户在两组,这是更明显的PP组混合成本。这项研究表明,钢琴练习和积极的音乐聆听——在更高程度上进行钢琴练习——都能增强认知灵活性,特别是在与混音成本相关的持续控制机制方面。这两种干预都可能需要超过6个月的时间来诱导行为转移效应,对认知灵活性水平较低的个体尤其有益。(PsycInfo Database Record (c) 2024 APA,版权所有)。
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引用次数: 0
Experiential diversity theory of adult development and aging in daily life. 日常生活中成人发展和老龄化的经验多样性理论。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 DOI: 10.1037/pag0000858
Rachel E Koffer, Soomi Lee, Johanna Drewelies

Present theories on adult development and aging offer insights into how aging is characterized by gains and losses across different domains (e.g., social, emotional, physical, and cognitive). Such gains and losses are related to changes in behaviors and experiences across various facets of daily life. However, much of the literature has focused on overall quantity of experiences rather than how such experiences are spread across different types. In this article, we propose that experiential diversity, conceptualized as rich and balanced experiences, is an important component of healthy and resilient aging. A conceptual framework demonstrates the theoretical underpinnings associating person-environment interactions with differences in experiential diversity and linking experiential diversity with aging-related outcomes. Experiential diversity is also discussed in the context of ontogenetic and sociohistorical change processes. Advances in empirical studies of experiential diversity across three representative domains of daily experiences (activities, stressors, and emotions) demonstrate how diversity of experiences declines with age. We further provide methodological (e.g., quantification, measurement, and timescales) and theoretical (e.g., moderators and cross-domain considerations) considerations for future studies on experiential diversity beyond the daily domains. Experiential diversity theory provides a theoretical leap, taking advantage of rich categorical data measured in studies of psychology and aging, and allowing for more nuanced consideration of the role of diverse experiences for healthy aging. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

目前关于成人发展和老龄化的理论提供了关于老龄化在不同领域(如社会、情感、身体和认知)的得失特点的见解。这些得失与日常生活各方面的行为和经历的变化有关。然而,大部分文献关注的是体验的总体数量,而不是这些体验如何分布在不同类型中。在这篇文章中,我们提出,经验多样性(概念化为丰富而均衡的经验)是健康而有弹性的老龄化的重要组成部分。一个概念框架展示了将人与环境的互动与体验多样性的差异联系起来,并将体验多样性与衰老相关结果联系起来的理论基础。经验多样性还在本体和社会历史变化过程的背景下进行了讨论。对日常经验的三个代表性领域(活动、压力源和情绪)的经验多样性的实证研究进展证明了经验多样性是如何随着年龄的增长而减少的。我们进一步提供了方法论(如量化、测量和时间尺度)和理论(如调节因素和跨领域考虑因素)方面的考虑因素,供未来对日常领域以外的体验多样性进行研究时参考。体验多样性理论提供了理论上的飞跃,它利用了心理学和老龄化研究中测量到的丰富的分类数据,并允许更细致地考虑不同体验对健康老龄化的作用。(PsycInfo Database Record (c) 2024 APA,保留所有权利)。
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引用次数: 0
The coping, appraisal, and resilience in aging (CARA) model: Longitudinal findings from the Normative Aging Study. 老龄化中的应对、评价和弹性(CARA)模型:来自规范老龄化研究的纵向研究结果。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 DOI: 10.1037/pag0000863
Carolyn Aldwin, Soyoung Choun, Avron Spiro

Resilience is central to understanding how individuals withstand the adverse effects of stress, but there is no generally agreed-upon definition of what constitutes resilience in later life. The present study tests the coping, appraisal, and resilience in aging model, which posits that resilient older adults, when faced with a problem, can draw upon their lifelong experience to minimize coping effort to conserve resources but still maintain a sense of coping efficacy (perceptions of how well they had handled the specific problem). We assessed coping effort and efficacy in 896 men in the Veterans' Affairs Normative Aging Study (Mage in 1993 = 64.46, SD = 6.6, range = 50-89) who were followed for 24 years (1993-2016), providing 3,459 observations. Multilevel modeling showed that coping effort decreased significantly, but coping efficacy showed only modest decreases with age. Group-based multitrajectory models indicated three groups. Struggling Copers (22.4%) had low, stable coping effort and efficacy. Modest Decliners (36.9%) had moderate levels of coping effort and high efficacy, both of which decreased with age. Optimal Copers (40.7%) had initially high coping effort, which declined more steeply, and stable, high coping efficacy. Struggling Copers were highest on neuroticism and pessimism at baseline, while Modest Decliners were lowest on neuroticism and highest on extraversion. The complex pattern of results suggested that both resource conservation and decreasing perceived control models were applicable, but to different subgroups. Nonetheless, nearly 80% of the sample were able to sustain high levels of coping efficacy, indicating good resilience in later life. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

抗逆力对于理解个人如何抵御压力的不利影响至关重要,但对于什么是晚年抗逆力却没有一个普遍认同的定义。本研究对老龄化中的应对、评估和复原力模型进行了测试,该模型认为,具有复原力的老年人在遇到问题时,可以利用其毕生经验最大限度地减少应对努力,以节省资源,但仍能保持应对效能感(对自己处理具体问题的能力的感知)。我们对退伍军人事务正常老龄化研究中的 896 名男性(1993 年年龄 = 64.46,SD = 6.6,范围 = 50-89)的应对努力和效能进行了评估,对他们进行了长达 24 年(1993-2016 年)的跟踪调查,共观察到 3,459 人。多层次模型显示,随着年龄的增长,应对努力显著下降,但应对效能仅略有下降。基于群体的多轨迹模型显示出三个群体。挣扎应对者(22.4%)的应对努力和效能较低且稳定。中度衰退者(36.9%)具有中等水平的应对努力和较高的效能,两者都随着年龄的增长而下降。最佳应对者(40.7%)最初的应对努力较高,但下降幅度较大,应对效能稳定且较高。挣扎型应对者的神经质和悲观程度在基线时最高,而温和型应对者的神经质最低,外向性最高。复杂的结果模式表明,资源保护模式和感知控制能力下降模式都适用于不同的亚群体。尽管如此,近 80% 的样本仍能保持较高的应对效能,这表明他们在晚年具有良好的复原能力。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
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引用次数: 0
Emotional support across adulthood: A 60-year study of men's social networks. 成年后的情感支持:长达 60 年的男性社交网络研究。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI: 10.1037/pag0000843
Kate Petrova, Michael D Nevarez, Robert J Waldinger, Marc S Schulz

Past research shows that social networks get smaller with age. But not all types of relationships may shrink at the same rate or for similar reasons. In the present study, we used a unique data set from a sample of 235 men who were followed longitudinally for 71 years to examine how the general pattern of network shrinkage documented in previous research generalizes to the number of emotional support providers in people's networks. We additionally examined early-life predictors of the size of later-life support network. Growth curve analyses revealed that, mirroring the more general pattern of network shrinkage, emotional support networks shrink by as much as 50% between the ages of 30 and 90, reflecting an average reduction from two to one support providers. Examining the associations between prospectively collected measures of childhood family environment and later-life emotional support, we also found that men who grew up in warmer family environments had larger support networks in adulthood. In contrast, childhood family socioeconomic status was not connected to the size of emotional support networks later in life. The generalizability of this work is limited by the use of an archival all-male sample from the United States. Despite this limitation, these findings make important contributions to our understanding of adult socioemotional development and underscore the importance of prospectively collected longitudinal data in developmental research. Additional research is needed to examine the consequences of changing emotional support across the lifespan for health and well-being. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

过去的研究表明,社交网络会随着年龄的增长而缩小。但并非所有类型的关系都会以相同的速度或出于类似的原因缩小。在本研究中,我们使用了一个独特的数据集,对 235 名男性进行了长达 71 年的纵向跟踪调查,以研究以往研究中记录的人际关系网络缩减的一般模式如何扩展到人们人际关系网络中情感支持提供者的数量。此外,我们还研究了晚年支持网络规模的早期预测因素。增长曲线分析表明,与更普遍的网络萎缩模式一样,情感支持网络在 30 岁到 90 岁之间的萎缩幅度高达 50%,反映出支持提供者平均从两个减少到一个。在研究前瞻性收集的童年家庭环境与晚年情感支持之间的关联时,我们还发现,在温暖家庭环境中长大的男性,其成年后的支持网络更大。相比之下,童年时期的家庭社会经济地位与日后生活中情感支持网络的规模没有关系。由于使用的是来自美国的全男性档案样本,这项研究的推广性受到了限制。尽管存在这种局限性,但这些发现对我们理解成人社会情感发展做出了重要贡献,并强调了前瞻性收集纵向数据在发展研究中的重要性。我们还需要进行更多的研究,以探讨在整个生命周期中,情感支持的变化对健康和幸福的影响。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
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引用次数: 0
Retirement and life satisfaction among middle-aged and older adults: A piecewise growth mixture analysis. 中老年人的退休和生活满意度:片断增长混合分析。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1037/pag0000853
Jonathan L Chia, Andree Hartanto, William Tov

Retirement represents a significant life transition typically occurring in later adulthood, often accompanied by substantial lifestyle changes. Several theoretical frameworks suggest that these changes present both opportunities and challenges for well-being, and the extent to which individuals experience positive versus negative well-being outcomes may be influenced by various factors. To study such heterogeneity in retirement experiences, researchers have embraced person-centered methodologies. Yet, some previous studies have not robustly delineated retirement- from age-related changes in well-being, accounted for statistical uncertainties, or examined these diverse experiences outside of a Western context. These limitations preclude conclusions about the diverse experience of retirement. Using both person- and variable-centered approaches, this study examined life satisfaction trajectories before and after retirement among 532 retired middle-aged and older adults from the Singapore Life Panel. Controlling for age-related changes, latent growth mixture analysis was employed to identify retirement subgroups with varying life satisfaction trajectories. Three distinct trajectories were revealed-decreasingly satisfied, stable postretirement, and increasingly satisfied. As compared to those increasingly satisfied, decreasingly satisfied individuals tended to have lower social support, were higher on neuroticism, and had higher income. While expressed to a similar magnitude across profiles, education and religious activity also emerged as important predictors of well-being in retirement transition. Findings from the present study highlight the importance of recognizing heterogeneity in retirement experiences and opportunities for targeted interventions to support retirees' well-being. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

退休是人生的一次重大转变,通常发生在成年晚期,往往伴随着生活方式的重大改变。一些理论框架认为,这些变化对幸福感来说既是机遇也是挑战,而个人在幸福感方面的积极与消极程度可能会受到各种因素的影响。为了研究退休经历的这种异质性,研究人员采用了以人为本的方法。然而,之前的一些研究并没有将退休与年龄相关的幸福感变化有力地划分开来,也没有考虑统计上的不确定性,或在西方背景之外研究这些不同的体验。这些局限性使得我们无法对退休后的不同经历得出结论。本研究采用以人为中心和以变量为中心的方法,对新加坡生活小组中 532 名退休中老年人退休前后的生活满意度轨迹进行了研究。在控制了与年龄相关的变化后,采用了潜在增长混合分析法来识别具有不同生活满意度轨迹的退休亚群。结果显示了三种不同的轨迹--满意度下降、退休后稳定和满意度上升。与越来越满意的人相比,越来越不满意的人往往社会支持较少,神经质程度较高,收入较高。教育和宗教活动也是预测退休过渡期幸福感的重要因素,但在不同情况下的表现程度相似。本研究的结果凸显了认识到退休经历异质性的重要性,以及采取有针对性的干预措施以支持退休人员幸福感的机会。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
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引用次数: 0
Associative memory in older adults: Making sense of associative memory deficits and hyperbinding effects. 老年人的联想记忆:联想记忆缺陷和过度结合效应的意义。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 DOI: 10.1037/pag0000851
Joanna Hwang, Kathrine Whitman, Sharda Umanath

Aging is generally associated with differences in associative memory, which is memory for relationships between arbitrary pieces of information. There are two predominant explanations for age-related declines in associative memory: (a) the associative deficit hypothesis, which posits that older adults decline in their ability to form and retrieve associations, and (b) the inhibitory deficit hypothesis, which suggests that older adults bind more information together than intended-that is, they form and then struggle to ignore too many irrelevant associations, rather than bind too few appropriate associations. We sought to reconcile these two seemingly conflicting theories. First, we provide overviews of the two theoretical frameworks and their standard associated experimental paradigms. We then synthesize the existing literature in order to reach a resolution for the associative deficit hypothesis and inhibitory deficit hypothesis frameworks together: Evidence supporting both frameworks points to changes in effortful, controlled processing that lead to differential effects in associative memory function in aging. In revisiting the explanatory contribution of this long-standing theory of cognitive aging, we raise areas of interest and key considerations to advance future work on associative memory in older adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

衰老通常与联想记忆的差异有关,联想记忆是对任意信息之间关系的记忆。对于与年龄相关的联想记忆力下降,有两种主要的解释:(a)联想缺陷假说,即老年人形成和检索联想的能力下降;(b)抑制缺陷假说,即老年人将更多的信息绑定在一起,而不是将更多的信息绑定在一起。我们试图调和这两种看似矛盾的理论。首先,我们概述了这两种理论框架及其标准的相关实验范式。然后,我们对现有文献进行了综合,以共同解决联想缺失假说和抑制缺失假说框架的问题:支持这两个框架的证据都表明,在老龄化过程中,费力的、有控制的加工过程的变化会导致联想记忆功能的不同效果。在重新审视这一长期存在的认知老化理论的解释性贡献时,我们提出了一些值得关注的领域和关键考虑因素,以推动未来有关老年人联想记忆的工作。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
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引用次数: 0
Advancing theory-driven research in the psychological science of adult development and aging. 推进成人发展和老龄化心理科学的理论研究。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 DOI: 10.1037/pag0000865
Elizabeth A L Stine-Morrow, Robert West, Sheung-Tak Cheng, Lise Abrams, Denis Gerstorf, Karen Hooker, Ute Kunzmann, Cindy Lustig

Theory is critical for a developmental science that explains age-related change and stability in psychological phenomena-and their variation across generational and sociocultural contexts. This special issue presents four contributions that advance theoretical approaches to the psychological science of adult development and aging. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

理论对于解释心理现象中与年龄相关的变化和稳定及其在不同代际和社会文化背景下的差异的发展科学至关重要。本特刊介绍了四篇文章,这些文章推进了成人发展与老龄化心理科学的理论方法。(PsycInfo Database Record (c) 2024 APA,保留所有权利)。
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引用次数: 0
Effects of one-to-one music therapy in older adults with cognitive impairment: A randomized controlled trial. 一对一音乐疗法对认知障碍老年人的影响:随机对照试验
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 DOI: 10.1037/pag0000861
Anthony M A Mangiacotti, Ming Hung Hsu, Clare Barone, Martine Van Puyvelde, Alessandro Zandonà, Gianfranco Gabai, Michele Biasutti, Fabia Franco

This study investigated the effects of music therapy (MT), a nonpharmacological therapy, on cognitive, behavioral, and physiological outcomes in older adults with mild-to-moderate cognitive decline residing in care home settings. A randomized controlled trial design was employed, with 42 care home residents (Mage = 86.25 years) randomly assigned to either a one-to-one 16-week MT intervention or an active control group receiving storytelling. Experimental and control activities were matched on key aspects, and groups were equivalent at baseline concerning demographic factors, general health, cognitive-behavioral characteristics, and cognitive reserve levels. Pre/postintervention neuropsychological and behavioral measures were collected, alongside saliva samples for cortisol/dehydroepiandrosterone ratio and respiratory sinus arrhythmia analysis as indicators of overall stress and autonomic regulation. The MT group exhibited benefits in cognitive, behavioral, and physiological domains, suggesting potential advantages in maintaining cognitive functioning and reducing neuropsychiatric symptoms. Biomarkers indicated possible mechanisms underlying the effectiveness of MT. The 16 one-to-one interactive MT sessions-delivered over 5 months-had a positive impact on older adults with mild-to-moderate cognitive decline living in care home settings. The implications of these findings for healthy aging and suggestions for future research are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

本研究调查了音乐疗法(MT)这种非药物疗法对居住在护理之家的轻度至中度认知功能衰退老年人的认知、行为和生理结果的影响。该研究采用随机对照试验设计,将 42 名护理院居民(年龄 = 86.25 岁)随机分配到为期 16 周的一对一 MT 干预组或接受讲故事的积极对照组。实验组和对照组的活动在主要方面是匹配的,两组在人口统计因素、一般健康状况、认知行为特征和认知储备水平方面的基线是相同的。实验组收集了干预前/后的神经心理和行为测量数据,并采集唾液样本进行皮质醇/脱氢表雄酮比率和呼吸窦性心律失常分析,作为整体压力和自主神经调节的指标。MT 组在认知、行为和生理领域都表现出优势,这表明他们在维持认知功能和减少神经精神症状方面具有潜在优势。生物标志物表明了 MT 有效的可能机制。16节一对一互动式MT课程为期5个月,对居住在护理之家的轻度至中度认知功能衰退的老年人产生了积极影响。本文讨论了这些发现对健康老龄化的影响以及对未来研究的建议。(PsycInfo Database Record (c) 2024 APA, all rights reserved)。
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引用次数: 0
Kids or no kids? Life goals in one's 20s predict midlife trajectories of well-being. 要孩子还是不要孩子?20 多岁时的人生目标预示着中年后的幸福轨迹。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 DOI: 10.1037/pag0000862
Laura Buchinger, Iris V Wahring, Nilam Ram, Christiane A Hoppmann, Jutta Heckhausen, Denis Gerstorf

For many people, parenthood constitutes a crucial part of a successful life. Yet, the number of adults who never have children is increasing and has prompted concerns about their well-being. Past research mostly focused on parents and rarely investigated factors that are theoretically meaningful for the well-being of adults without children. Our preregistered study uses a propensity-score matched design to investigate how life goals contribute to differences between adults with and without children in the development of eight well-being facets. Leveraging data from the German Socio-Economic Panel, we constructed a matched sample comprising N = 562 individuals (average participation = 24.9 waves) who provided data from when they were young adults (ages 18-30) to an age when parenthood becomes less likely (age 40 for women, age 50 for men). We find almost no significant differences in the average midlife well-being trajectories of adults with and without children. Only in young adulthood, people without children reported better mental health, lower negative affect as well as lower positive affect, and more loneliness. Select evidence for a gender moderation suggests that fathers were less lonely than mothers as well as men and women without children. Prioritizing the goal to have children during early adulthood was related to lower midlife mental health, cognitive, and affective well-being in adults without children, but not in parents. Disengaging from the goal to have children was associated with positive changes in life satisfaction in adults without children. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

对许多人来说,为人父母是成功人生的重要组成部分。然而,没有孩子的成年人数量正在增加,这引发了人们对他们福祉的担忧。过去的研究主要集中在父母身上,很少调查那些理论上对没有孩子的成年人的幸福有意义的因素。我们的预登记研究使用倾向分数匹配设计来调查生活目标如何影响有孩子和没有孩子的成年人在八个幸福方面的发展差异。利用德国社会经济小组的数据,我们构建了一个匹配的样本,包括N = 562个人(平均参与= 24.9波),他们提供了从年轻成人(18-30岁)到不太可能成为父母的年龄(女性40岁,男性50岁)的数据。我们发现,有孩子和没有孩子的成年人的平均中年幸福轨迹几乎没有显著差异。只有在年轻的成年期,没有孩子的人心理健康状况更好,消极影响和积极影响都更低,孤独感也更强。性别适度的精选证据表明,父亲比母亲以及没有孩子的男性和女性更不孤独。在成年早期优先考虑要孩子的目标与没有孩子的成年人中年较低的心理健康、认知和情感健康有关,但与父母无关。在没有孩子的成年人中,放弃要孩子的目标与生活满意度的积极变化有关。(PsycInfo Database Record (c) 2024 APA,版权所有)。
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引用次数: 0
Are depressive symptoms associated with biological aging in a cross-sectional analysis of adults over age 50 in the United States. 对美国 50 岁以上成年人进行的横断面分析显示,抑郁症状是否与生理衰老有关。
IF 3.7 1区 心理学 Q1 GERONTOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI: 10.1037/pag0000860
Herong Wang, Kelly M Bakulski, Freida Blostein, Brittany R Porath, John Dou, César Higgins Tejera, Lindsay H Ryan, Erin B Ware

Major depressive disorder accelerates DNA methylation age, a biological aging marker. Subclinical depressive symptoms are common, but their link to DNA methylation aging in older adults remains unexplored. This study analyzed the cross-sectional relationship between depressive symptoms and accelerated DNA methylation aging, considering gender and race/ethnicity in U.S. adults aged over 50. We used data from 3,882 diverse participants in the 2016 Health and Retirement Study wave, measuring blood DNA methylation age against chronologic age for acceleration. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression evaluated the association between depressive symptoms and DNA methylation age acceleration, adjusting for sociodemographic factors, blood cell proportions, and health behaviors (physical activity, alcohol use, smoking, and chronic conditions). Gender and race/ethnicity modifications were also tested. Depressive symptoms, measured by continuous CES-D score, high depressive symptoms (CES-D ≥ 4), or any symptoms (CES-D ≥ 1), significantly correlated with increased GrimAge DNA methylation age acceleration (all p ≤ .001) in unadjusted and sociodemographic-adjusted models but were nonsignificant in fully adjusted models. No significant gender or race/ethnicity effect modifications were found in fully adjusted models. Health behaviors significantly influence DNA methylation age acceleration and depressive phenotypes, underscoring the need to understand their roles in assessing psychological factors related to DNA methylation age acceleration. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

重度抑郁症会加速生物衰老标志 DNA 甲基化的衰老。亚临床抑郁症状很常见,但它们与老年人 DNA 甲基化老化之间的联系仍未得到研究。本研究分析了美国 50 岁以上成年人中抑郁症状与 DNA 甲基化加速老化之间的横断面关系,同时考虑了性别和种族/民族因素。我们使用了 2016 年健康与退休研究(Health and Retirement Study)波中 3882 名不同参与者的数据,测量了血液 DNA 甲基化年龄与计时年龄的加速度。抑郁症状采用流行病学研究中心抑郁(CES-D)量表进行评估。多元线性回归评估了抑郁症状与 DNA 甲基化年龄加速之间的关联,并对社会人口因素、血细胞比例和健康行为(体育锻炼、饮酒、吸烟和慢性病)进行了调整。此外,还测试了性别和种族/人种修正情况。在未调整和社会人口因素调整模型中,以连续 CES-D 评分、高抑郁症状(CES-D ≥ 4)或任何症状(CES-D ≥ 1)衡量的抑郁症状与 GrimAge DNA 甲基化年龄加速度的增加显著相关(所有 p 均小于 .001),但在完全调整模型中不显著。在完全调整模型中,没有发现明显的性别或种族/人种效应修正。健康行为对DNA甲基化年龄加速和抑郁表型有重大影响,这说明在评估与DNA甲基化年龄加速有关的心理因素时,需要了解健康行为的作用。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
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Psychology and Aging
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