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Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial.
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-28 DOI: 10.2196/62782
Auguste Nomeikaite, Odeta Gelezelyte, Maria Böttche, Gerhard Andersson, Evaldas Kazlauskas

Background: Prompts offer a promising strategy to promote client engagement in internet-delivered cognitive behavioral therapy (ICBT). However, if the prompts do not meet the needs of clients, they can potentially be more obtrusive rather than helpful.

Objective: The aim of this study was to test if prompts tailored based on timing and frequency, aligned with preintervention goal setting, can increase usage and the efficacy of a therapist-supported ICBT stress recovery intervention for health care workers.

Methods: The 2-arm randomized controlled trial included 87 health care workers (99% female, aged 19-68 years: mean 39.61, SD 11.49): 43 in the standard intervention group and 44 in the tailored prompts group. The primary outcome measure was the Recovery Experiences Questionnaire, and the secondary outcomes were the Perceived Stress Scale-4, the Patient Health Questionnaire-4, and the World Health Organization-5 Well-Being Index. The self-report data were collected before the intervention (September 2022), postintervention (October 2022), and 6-month follow-up (May 2023).

Results: The results showed that tailored prompts, although appreciated by the majority (39/40, 98%), did not improve intervention usage indicators, such as the number of logins (t85=-0.91; P=.36), modules opened (t83.57=-1.47; P=.15), modules completed (t85=-0.71; P=.48), exercises completed (t85=-1.05; P=.30), or the time spent using the program (χ22=1.1; P=.57). Similarly, tailored prompts did not increase the effects of the intervention in terms of stress recovery skills (Cohen d ranging from 0.31 to 0.85), perceived stress (d=-0.08; -0.70), depression (d=-0.11; -0.38), anxiety (d=-0.32; -0.64), or psychological well-being (d=0.26; 0.46). In addition, the standard intervention group showed greater long-term stress recovery effects than the group using the internet-delivered intervention supplemented by tailored prompts (β=-0.24, P=.03).

Conclusions: Although the study confirmed the efficacy of the program, the merits of tailored prompts in ICBT for stress recovery were not supported. Future research is needed to test the effects of the stress recovery intervention supplemented by goal setting and tailored prompts.

Trial registration: ClinicalTrials.gov NCT05553210; https://clinicaltrials.gov/study/NCT05553210.

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引用次数: 0
Exploring the Psychological and Physiological Insights Through Digital Phenotyping by Analyzing the Discrepancies Between Subjective Insomnia Severity and Activity-Based Objective Sleep Measures: Observational Cohort Study.
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-27 DOI: 10.2196/67478
Ji Won Yeom, Hyungju Kim, Seung Pil Pack, Heon-Jeong Lee, Taesu Cheong, Chul-Hyun Cho
<p><strong>Background: </strong>Insomnia is a prevalent sleep disorder affecting millions worldwide, with significant impacts on daily functioning and quality of life. While traditionally assessed through subjective measures such as the Insomnia Severity Index (ISI), the advent of wearable technology has enabled continuous, objective sleep monitoring in natural environments. However, the relationship between subjective insomnia severity and objective sleep parameters remains unclear.</p><p><strong>Objective: </strong>This study aims to (1) explore the relationship between subjective insomnia severity, as measured by ISI scores, and activity-based objective sleep parameters obtained through wearable devices; (2) determine whether subjective perceptions of insomnia align with objective measures of sleep; and (3) identify key psychological and physiological factors contributing to the severity of subjective insomnia complaints.</p><p><strong>Methods: </strong>A total of 250 participants, including both individuals with and without insomnia aged 19-70 years, were recruited from March 2023 to November 2023. Participants were grouped based on ISI scores: no insomnia, mild, moderate, and severe insomnia. Data collection involved subjective assessments through self-reported questionnaires and objective measurements using wearable devices (Fitbit Inspire 3) that monitored sleep parameters, physical activity, and heart rate. The participants also used a smartphone app for ecological momentary assessment, recording daily alcohol consumption, caffeine intake, exercise, and stress. Statistical analyses were used to compare groups on subjective and objective measures.</p><p><strong>Results: </strong>Results indicated no significant differences in general sleep structure (eg, total sleep time, rapid eye movement sleep time, and light sleep time) among the insomnia groups (mild, moderate, and severe) as classified by ISI scores (all P>.05). Interestingly, the no insomnia group had longer total awake times and lower sleep quality compared with the insomnia groups. Among the insomnia groups, no significant differences were observed regarding sleep structure (all P>.05), suggesting similar sleep patterns regardless of subjective insomnia severity. There were significant differences among the insomnia groups in stress levels, dysfunctional beliefs about sleep, and symptoms of restless leg syndrome (all P≤.001), with higher severity associated with higher scores in these factors. Contrary to expectations, no significant differences were observed in caffeine intake (P=.42) and alcohol consumption (P=.07) between the groups.</p><p><strong>Conclusions: </strong>The findings demonstrate a discrepancy between subjective perceptions of insomnia severity and activity-based objective sleep parameters, suggesting that factors beyond sleep duration and quality may contribute to subjective sleep complaints. Psychological factors, such as stress, dysfunctional sleep beliefs, and
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引用次数: 0
Establishment and Maintenance of a Digital Therapeutic Alliance in People Living With Negative Symptoms of Schizophrenia: Two Exploratory Single-Arm Studies.
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-27 DOI: 10.2196/64959
Cassandra Snipes, Cornelia Dorner-Ciossek, Brendan D Hare, Olya Besedina, Tim Campellone, Mariya Petrova, Shaheen E Lakhan, Abhishek Pratap
<p><strong>Background: </strong>Evidence-based digital therapeutics represent a new treatment modality in mental health, potentially providing cost-efficient, accessible means of augmenting existing treatments for chronic mental illnesses. CT-155/BI 3972080 is a prescription digital therapeutic under development as an adjunct to standard of care treatments for patients 18 years of age and older with experiential negative symptoms (ENS) of schizophrenia. Individual components of CT-155/BI 3972080 are designed based on the underlying principles of face-to-face treatment. A positive therapeutic alliance between patients and health care providers is linked with improved clinical outcomes in mental health. Likewise, establishing a similar therapeutic alliance with a digital therapeutic (ie, digital working alliance [DWA]) may be important for engagement and treatment effectiveness of this modality.</p><p><strong>Objective: </strong>This study aimed to investigate the establishment and maintenance of a DWA between a beta version of CT-155/BI 3972080 (CT-155 beta) and adults with ENS of schizophrenia.</p><p><strong>Methods: </strong>Two multicenter, exploratory, single-arm studies (study 1: CT-155-C-001 and study 2: CT-155-C-002) enrolled adults with schizophrenia and ENS receiving stable antipsychotic medication (≥12 weeks). Participants had access to CT-155 beta and were presented with daily in-app activities during a 3-week orientation phase that included lessons designed to facilitate building of a DWA. In study 2, the 3-week orientation phase was followed by an abbreviated active 4-week phase. Digital literacy at baseline was evaluated using the Mobile Device Proficiency Questionnaire (MDPQ). The mobile Agnew Relationship Measure (mARM) was used to assess DWA establishment after 3 weeks in both studies, and after 7 weeks in study 2 to assess DWA maintenance. Participant safety, digital literacy, and correlations between negative symptom severity and DWA were assessed in both studies.</p><p><strong>Results: </strong>Of the enrolled participants, 94% (46/49) and 86% (43/50) completed studies 1 and 2, respectively. Most were male (study 1: 71%, 35/49; study 2: 80%, 40/50). The baseline digital literacy assessed through MDPQ score was comparable in both studies (study 1: mean 30.56, SD 8.06; study 2: mean 28.69, SD 8.31) indicating proficiency in mobile device use. After 3 weeks, mARM scores (study 1: mean 5.16, SD 0.8; study 2: mean 5.36, SD 1.06) indicated that a positive DWA was established in both studies. In study 2, the positive DWA established at week 3 was maintained at week 7 (mARM: mean 5.48, SD 0.97). There were no adverse events (AEs) in study 1, and 3 nonserious and nontreatment-related AEs in study 2.</p><p><strong>Conclusions: </strong>A positive DWA was established between participants and CT-155 beta within 3 weeks. The second 7-week study showed maintenance of the DWA to the end of the study. Results support the establishment and main
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引用次数: 0
Effectiveness of Digital Mental Health Interventions in the Workplace: Umbrella Review of Systematic Reviews.
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-24 DOI: 10.2196/67785
Gillian Cameron, Maurice Mulvenna, Edel Ennis, Siobhan O'Neill, Raymond Bond, David Cameron, Alex Bunting

Background: There is potential for digital mental health interventions to provide affordable, efficient, and scalable support to individuals. Digital interventions, including cognitive behavioral therapy, stress management, and mindfulness programs, have shown promise when applied in workplace settings.

Objective: The aim of this study is to conduct an umbrella review of systematic reviews in order to critically evaluate, synthesize, and summarize evidence of various digital mental health interventions available within a workplace setting.

Methods: A systematic search was conducted to identify systematic reviews relating to digital interventions for the workplace, using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). The review protocol was registered in the Open Science Framework. The following databases were searched: PubMed, Web of Science, MEDLINE, PsycINFO, and Cochrane Library. Data were extracted using a predefined extraction table. To assess the methodological quality of a study, the AMSTAR-2 tool was used to critically appraise systematic reviews of health care interventions.

Results: The literature search resulted in 11,875 records, which was reduced to 14 full-text systematic literature reviews with the use of Covidence to remove duplicates and screen titles and abstracts. The 14 included reviews were published between 2014 and 2023, comprising 9 systematic reviews and 5 systematic reviews and meta-analyses. AMSTAR-2 was used to complete a quality assessment of the reviews, and the results were critically low for 7 literature reviews and low for the other 7 literature reviews. The most common types of digital intervention studied were cognitive behavioral therapy, mindfulness/meditation, and stress management followed by other self-help interventions. Effectiveness of digital interventions was found for many mental health symptoms and conditions in employee populations, such as stress, anxiety, depression, burnout, and psychological well-being. Factors such as type of technology, guidance, recruitment, tailoring, and demographics were found to impact effectiveness.

Conclusions: This umbrella review aimed to critically evaluate, synthesize, and summarize evidence of various digital mental health interventions available within a workplace setting. Despite the low quality of the reviews, best practice guidelines can be derived from factors that impact the effectiveness of digital interventions in the workplace.

Trial registration: OSF Registries osf.io/rc6ds; https://doi.org/10.17605/OSF.IO/RC6DS.

背景:数字心理健康干预有望为个人提供经济、高效和可扩展的支持。包括认知行为疗法、压力管理和正念计划在内的数字化干预措施在工作场所的应用前景良好:本研究旨在对系统综述进行总体回顾,以批判性地评估、综合和总结工作场所环境中各种数字心理健康干预措施的证据:方法:采用 PRISMA(系统性综述和元分析的首选报告项目)进行了系统性检索,以确定与工作场所的数字化干预措施相关的系统性综述。综述协议已在开放科学框架中注册。对以下数据库进行了检索:PubMed、Web of Science、MEDLINE、PsycINFO 和 Cochrane Library。使用预定义的提取表提取数据。为了评估研究的方法学质量,使用了 AMSTAR-2 工具对医疗保健干预措施的系统性综述进行批判性评估:文献检索共获得 11,875 条记录,通过使用 Covidence 去除重复内容并筛选标题和摘要,最终筛选出 14 篇全文系统性文献综述。收录的 14 篇综述发表于 2014 年至 2023 年之间,其中包括 9 篇系统综述和 5 篇系统综述与荟萃分析。我们使用 AMSTAR-2 完成了对综述的质量评估,结果显示 7 篇文献综述的质量为极低,另外 7 篇文献综述的质量为低。研究中最常见的数字干预类型是认知行为疗法、正念/冥想和压力管理,其次是其他自助干预。研究发现,数字化干预对员工群体的许多心理健康症状和状况都有效果,如压力、焦虑、抑郁、职业倦怠和心理健康。研究发现,技术类型、指导、招聘、量身定制和人口统计学等因素都会影响干预效果:本综述旨在批判性地评估、综合和总结工作场所环境中各种数字心理健康干预措施的证据。尽管综述的质量不高,但可以从影响工作场所数字干预效果的因素中得出最佳实践指南:OSF Registries osf.io/rc6ds;https://doi.org/10.17605/OSF.IO/RC6DS。
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引用次数: 0
Integrating Videoconferencing Therapist Guidance Into Stepped Care Internet-Delivered Cognitive Behavioral Therapy for Child and Adolescent Anxiety: Noninferiority Randomized Controlled Trial.
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-22 DOI: 10.2196/57405
Sonja March, Susan H Spence, Larry Myers, Martelle Ford, Genevieve Smith, Caroline L Donovan
<p><strong>Background: </strong>Self-guided internet-delivered cognitive behavioral therapy (ICBT) achieves greater reach than ICBT delivered with therapist guidance, but demonstrates poorer engagement and fewer clinical benefits. Alternative models of care are required that promote engagement and are effective, accessible, and scalable.</p><p><strong>Objective: </strong>This randomized trial evaluated whether a stepped care approach to ICBT using therapist guidance via videoconferencing for the step-up component (ICBT-SC[VC]) is noninferior to ICBT with full therapist delivery by videoconferencing (ICBT-TG[VC]) for child and adolescent anxiety.</p><p><strong>Methods: </strong>Participants included 137 Australian children and adolescents aged 7 to 17 years (male: n=61, 44.5%) with a primary anxiety disorder who were recruited from participants presenting to the BRAVE Online website. This noninferiority randomized trial compared ICBT-SC[VC] to an ICBT-TG[VC] program, with assessments conducted at baseline, 12 weeks, and 9 months after treatment commencement. All ICBT-TG[VC] participants received therapist guidance (videoconferencing) after each session for all 10 sessions. All ICBT-SC[VC] participants completed the first 5 sessions online without therapist guidance. If they demonstrated response to treatment after 5 sessions (defined as reductions in anxiety symptoms to the nonclinical range), they continued sessions without therapist guidance. If they did not respond, participants were stepped up to receive supplemental therapist guidance (videoconferencing) for the remaining sessions. The measures included a clinical diagnostic interview (Anxiety Disorders Interview Schedule) with clinician-rated severity rating as the primary outcome and parent- and child-reported web-based surveys assessing anxiety and anxiety-related interference (secondary outcomes).</p><p><strong>Results: </strong>Although there were no substantial differences between the treatment conditions on primary and most secondary outcome measures, the noninferiority of ICBT-SC[VC] compared to ICBT-TG[VC] could not be determined. Significant clinical benefits were evident for participants in both treatments, although this was significantly higher for the ICBT-TG[VC] participants. Of the 89 participants (38 in ICBT-SC[VC] and 51 in ICBT-TG[VC]) who remained in the study, 26 (68%) in ICBT-SC[VC] and 45 (88%) in ICBT-TG[VC] were free of their primary anxiety diagnosis by the 9-month follow-up. For the intention-to-treat sample (N=137), 41% (27/66) ICBT-SC[VC], and 69% (49/71) ICBT-TG[VC] participants were free of their primary anxiety diagnosis. Therapy compliance was lower for the ICBT-SC[VC] participants (mean 7.39, SD 3.44 sessions) than for the ICBT-TG[VC] participants (mean 8.73, SD 3.08 sessions), although treatment satisfaction was moderate to high in both conditions.</p><p><strong>Conclusions: </strong>This study provided further support for the benefits of low-intensity ICBT f
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引用次数: 0
Impact of a Virtual Reality Intervention on Stigma, Empathy, and Attitudes Toward Patients With Psychotic Disorders Among Mental Health Care Professionals: Randomized Controlled Trial. 虚拟现实干预对精神卫生保健专业人员对精神病患者的污名、共情和态度的影响:随机对照试验
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-21 DOI: 10.2196/66925
Jing Ling Tay, Yuanrong Qu, Lucas Lim, Rohan Puthran, Chye Lee Robert Tan, Rajkirren Rajendran, Ker Chiah Wei, Huiting Xie, Kang Sim

Background: Previous studies have found that psychotic disorders are among the most stigmatized mental disorders. Of note, virtual reality (VR) interventions have been associated with improvements in attitudes and empathy and reduced stigma toward individuals with psychotic disorders, especially among undergraduates, but this has not been examined among mental health care professionals.

Objective: We aimed to evaluate the effectiveness of a newly developed VR intervention for mental health care professionals to improve attitudes and empathy and reduce stigma toward people with psychotic disorders.

Methods: We conducted a randomized controlled trial and recruited eligible mental health care professionals from a tertiary mental health care institution. Both arms (VR intervention and VR control groups) were evaluated at baseline, postintervention, and 1-month follow up. The evaluation included outcomes related to attitudes (modified attitudes toward people with schizophrenia scale), stigma (social distance scale, personal stigma scale), and empathy (empathetic concern subscale of the Interpersonal Reactivity Index). The experience with the VR intervention was assessed using a user satisfaction questionnaire, and qualitative feedback was gathered.

Results: Overall, 180 mental health care professionals participated and completed the study. Both groups showed improvements in attitude, social distance, and stigma scores but not the empathy score following the intervention. The VR intervention group had better user satisfaction than the VR control group. In addition, certain outcome measures were positively associated with specific factors including female gender, higher education level, certain job roles, years of work, and presence of loved ones with a mental disorder.

Conclusions: Both the intervention and control VR groups of mental health care professionals showed improvements in attitudes, stigma, and social distance toward people with psychotic disorders. Future longitudinal studies may want to evaluate the impact of VR on caregivers and the public on these same and other outcome measures to reduce stigma and improve empathy toward individuals with psychotic disorders.

Trial registration: clinicaltrials.gov NCT05982548; https://clinicaltrials.gov/study/NCT05982548.

背景:以往的研究发现,精神障碍是最容易被污名化的精神障碍之一。值得注意的是,虚拟现实(VR)干预与态度和同理心的改善有关,并减少了对精神病患者的耻辱感,尤其是在大学生中,但这还没有在精神卫生保健专业人员中进行过研究。目的:我们旨在评估新开发的虚拟现实干预对精神卫生保健专业人员改善精神障碍患者的态度和同理心并减少耻辱感的有效性。方法:我们进行了一项随机对照试验,并从一家三级精神卫生保健机构招募了符合条件的精神卫生保健专业人员。两组(VR干预组和VR对照组)在基线、干预后和1个月随访时进行评估。评估包括态度(对精神分裂症患者的修正态度量表)、耻感(社会距离量表、个人耻感量表)和共情(人际反应指数的共情关注子量表)相关的结果。使用用户满意度问卷评估虚拟现实干预的体验,并收集定性反馈。结果:总共有180名精神卫生保健专业人员参与并完成了这项研究。干预后,两组在态度、社会距离和污名得分上都有所改善,但在共情得分上没有改善。虚拟现实干预组用户满意度高于虚拟现实对照组。此外,某些结果测量与特定因素正相关,包括女性性别、高等教育水平、某些工作角色、工作年限和患有精神障碍的亲人。结论:干预组和对照组的精神卫生保健专业人员对精神障碍患者的态度、耻辱感和社会距离都有所改善。未来的纵向研究可能想要评估虚拟现实对护理人员和公众的影响,以减少对精神病患者的耻辱感,提高对精神病患者的同理心。试验注册:clinicaltrials.gov NCT05982548;https://clinicaltrials.gov/study/NCT05982548。
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引用次数: 0
Codeveloping an Online Resource for People Bereaved by Suicide: Mixed Methods User-Centered Study. 共同开发自杀遗属在线资源:以用户为中心的混合方法研究。
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-20 DOI: 10.2196/56945
Edouard Leaune, Kushtrim Bislimi, Pauline Lau-Taï, Héloïse Rouzé, Benoit Chalancon, Laurène Lestienne, Pierre Grandgenevre, Margot Morgiève, Nathalie Laplace, Guillaume Vaiva, Julie Haesebaert, Emmanuel Poulet

Background: Although suicide bereavement is highly distressing and is associated with an increased risk of suicidal behaviors and mental and physical health impairments, those bereaved by suicide encounter difficulties accessing support. Digital resources offer new forms of support for bereaved people. However, digital resources dedicated to those bereaved by suicide are still limited.

Objective: This paper aimed to develop and implement an evidence-based, innovative, and adaptive online resource for people bereaved by suicide, based on their needs and expectations.

Methods: We performed a mixed methods, participatory, user-centered study seeking to build resources from the perspectives of people bereaved by suicide and professionals or volunteers working in the field of postvention. We used the Information System Research framework, which uses a three-stage research cycle, including (1) the relevance cycle, (2) the design cycle, and (3) the rigor cycle, and the Design Science Research framework.

Results: A total of 478 people participated in the study, including 451 people bereaved by suicide, 8 members of charities, and 19 mental health professionals working in the field of postvention. The development stage of the resource lasted 18 months, from October 2021 to March 2023. A total of 9 focus groups, 1 online survey, 30 usability tests, and 30 semistructured interviews were performed. A website for people bereaved by suicide named "espoir-suicide" was developed that includes (1) evidence-based information on suicide prevention and bereavement, (2) testimonies of people bereaved by suicide, (3) a delayed chat to ask questions on suicide and bereavement to a specialized team of mental health professionals, and (4) an interactive nationwide resource directory. The mean system usability score was 90.3 out of 100 for 30 participants, with 93% (n=28) of them having a rating above 80. Since the implementation of espoir-suicide in March 2023, a total of 19,400 connections have been recorded, 117 local resources have been registered nationwide, and 73 questions have been posted in the chat.

Conclusions: The use of a mixed methods, participatory, user-centered design allowed us to implement an evidence-based, innovative, and functional website for people bereaved by suicide that was highly relevant for fulfilling the needs and expectations of French people bereaved by suicide.

International registered report identifier (irrid): RR2-10.3389/fpsyt.2021.770154.

背景:虽然自杀丧亲之痛非常令人痛苦,并与自杀行为和精神和身体健康损害的风险增加有关,但自杀丧亲之人在获得支持方面遇到困难。数字资源为丧亲者提供了新形式的支持。然而,专门为那些因自杀而失去亲人的人提供的数字资源仍然有限。目的:基于自杀者的需求和期望,为自杀者开发和实施一种基于证据、创新和适应性的在线资源。方法:我们进行了一项混合方法、参与式、以用户为中心的研究,试图从自杀丧亲者和在后发领域工作的专业人员或志愿者的角度建立资源。我们使用了信息系统研究框架,它使用了一个三阶段的研究周期,包括(1)相关周期,(2)设计周期,(3)严谨性周期,以及设计科学研究框架。结果:共有478人参与了这项研究,其中包括451名自杀者,8名慈善机构成员,19名在后发领域工作的精神卫生专业人员。该资源的开发阶段持续了18个月,从2021年10月到2023年3月。总共进行了9个焦点小组,1个在线调查,30个可用性测试和30个半结构化访谈。一个名为“espoire -suicide”的网站为自杀者开发,包括(1)关于自杀预防和丧亲的循证信息,(2)自杀者的证词,(3)向专门的心理健康专家团队询问自杀和丧亲问题的延迟聊天,以及(4)一个全国性的互动资源目录。30名参与者的平均系统可用性得分为90.3分(满分100分),其中93% (n=28)的评分高于80分。自2023年3月实施espoire -suicide以来,共记录了1.94万个连接,在全国范围内注册了117个地方资源,在聊天中发布了73个问题。结论:采用混合方法、参与式、以用户为中心的设计,使我们能够实现一个以证据为基础的、创新的、功能性的自杀丧亲者网站,这与满足法国自杀丧亲者的需求和期望高度相关。国际注册报告标识符(irrid): RR2-10.3389/fpsyt.2021.770154。
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引用次数: 0
Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthesis. 精神病或双相情感障碍患者参与数字心理健康干预的障碍和促进因素:系统回顾和最适合框架综合
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-20 DOI: 10.2196/65246
Emily Eisner, Sophie Faulkner, Stephanie Allan, Hannah Ball, Daniela Di Basilio, Jennifer Nicholas, Aansha Priyam, Paul Wilson, Xiaolong Zhang, Sandra Bucci

Background: Digital mental health interventions (DMHIs) to monitor and improve the health of people with psychosis or bipolar disorder show promise; however, user engagement is variable, and integrated clinical use is low.

Objective: This prospectively registered systematic review examined barriers and facilitators of clinician and patient engagement with DMHIs, to inform implementation within real-world settings.

Methods: A systematic search of 7 databases identified empirical studies reporting qualitative or quantitative data about factors affecting staff or patient engagement with DMHIs aiming to monitor or improve the mental or physical health of people with psychosis or bipolar disorder. The Consolidated Framework for Implementation Research was used to synthesize data on barriers and facilitators, following a best-fit framework synthesis approach.

Results: The review included 175 papers (150 studies; 11,446 participants) describing randomized controlled trials; surveys; qualitative interviews; and usability, cohort, and case studies. Samples included people with schizophrenia spectrum psychosis (98/150, 65.3% of studies), bipolar disorder (62/150, 41.3% of studies), and clinicians (26/150, 17.3% of studies). Key facilitators were a strong recognition of DMHIs' relative advantages, a clear link between intervention focus and specific patient needs, a simple, low-effort digital interface, human-supported delivery, and device provision where needed. Although staff thought patients would lose, damage, or sell devices, reviewed studies found only 11% device loss. Barriers included intervention complexity, perceived risks, user motivation, discomfort with self-reflection, digital poverty, symptoms of psychosis, poor compatibility with existing clinical workflows, staff and patient fears that DMHIs would replace traditional face-to-face care, infrastructure limitations, and limited financial support for delivery.

Conclusions: Identified barriers and facilitators highlight key considerations for DMHI development and implementation. As to broader implications, sustainable business models are needed to ensure that evidence-based DMHIs are maintained and deployed.

Trial registration: PROSPERO CRD42021282871; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=282871.

背景:数字心理健康干预(DMHIs)监测和改善精神病或双相情感障碍患者的健康显示出希望;然而,用户参与度是可变的,综合临床使用率很低。目的:这一前瞻性注册的系统评价检查了临床医生和患者参与DMHIs的障碍和促进因素,以告知在现实世界环境中的实施。方法:对7个数据库进行系统检索,确定了报告定性或定量数据的实证研究,这些数据涉及影响工作人员或患者参与DMHIs的因素,旨在监测或改善精神病或双相情感障碍患者的精神或身体健康。按照最合适的框架综合方法,使用《实施研究综合框架》综合有关障碍和促进因素的数据。结果:纳入175篇论文(150项研究;11446名受试者)描述随机对照试验;调查;定性访谈;可用性,群体和案例研究。样本包括精神分裂症谱系精神病患者(98/150,65.3%的研究)、双相情感障碍患者(62/150,41.3%的研究)和临床医生(26/150,17.3%的研究)。关键的促进因素是对DMHIs相对优势的强烈认识,干预重点与特定患者需求之间的明确联系,简单,低成本的数字界面,人工支持的交付以及需要时提供的设备。尽管工作人员认为患者会丢失、损坏或出售设备,但经过审查的研究发现,只有11%的设备丢失。障碍包括干预措施的复杂性、感知风险、用户动机、自我反思的不适、数字贫困、精神病症状、与现有临床工作流程的兼容性差、工作人员和患者担心DMHIs将取代传统的面对面护理、基础设施限制以及提供的财政支持有限。结论:已确定的障碍和促进因素突出了DMHI开发和实施的关键考虑因素。至于更广泛的影响,需要可持续的商业模式来确保维护和部署基于证据的DMHIs。试验注册:PROSPERO CRD42021282871;https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=282871。
{"title":"Barriers and Facilitators of User Engagement With Digital Mental Health Interventions for People With Psychosis or Bipolar Disorder: Systematic Review and Best-Fit Framework Synthesis.","authors":"Emily Eisner, Sophie Faulkner, Stephanie Allan, Hannah Ball, Daniela Di Basilio, Jennifer Nicholas, Aansha Priyam, Paul Wilson, Xiaolong Zhang, Sandra Bucci","doi":"10.2196/65246","DOIUrl":"https://doi.org/10.2196/65246","url":null,"abstract":"<p><strong>Background: </strong>Digital mental health interventions (DMHIs) to monitor and improve the health of people with psychosis or bipolar disorder show promise; however, user engagement is variable, and integrated clinical use is low.</p><p><strong>Objective: </strong>This prospectively registered systematic review examined barriers and facilitators of clinician and patient engagement with DMHIs, to inform implementation within real-world settings.</p><p><strong>Methods: </strong>A systematic search of 7 databases identified empirical studies reporting qualitative or quantitative data about factors affecting staff or patient engagement with DMHIs aiming to monitor or improve the mental or physical health of people with psychosis or bipolar disorder. The Consolidated Framework for Implementation Research was used to synthesize data on barriers and facilitators, following a best-fit framework synthesis approach.</p><p><strong>Results: </strong>The review included 175 papers (150 studies; 11,446 participants) describing randomized controlled trials; surveys; qualitative interviews; and usability, cohort, and case studies. Samples included people with schizophrenia spectrum psychosis (98/150, 65.3% of studies), bipolar disorder (62/150, 41.3% of studies), and clinicians (26/150, 17.3% of studies). Key facilitators were a strong recognition of DMHIs' relative advantages, a clear link between intervention focus and specific patient needs, a simple, low-effort digital interface, human-supported delivery, and device provision where needed. Although staff thought patients would lose, damage, or sell devices, reviewed studies found only 11% device loss. Barriers included intervention complexity, perceived risks, user motivation, discomfort with self-reflection, digital poverty, symptoms of psychosis, poor compatibility with existing clinical workflows, staff and patient fears that DMHIs would replace traditional face-to-face care, infrastructure limitations, and limited financial support for delivery.</p><p><strong>Conclusions: </strong>Identified barriers and facilitators highlight key considerations for DMHI development and implementation. As to broader implications, sustainable business models are needed to ensure that evidence-based DMHIs are maintained and deployed.</p><p><strong>Trial registration: </strong>PROSPERO CRD42021282871; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=282871.</p>","PeriodicalId":48616,"journal":{"name":"Jmir Mental Health","volume":"12 ","pages":"e65246"},"PeriodicalIF":4.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Responsible Design, Integration, and Use of Generative AI in Mental Health.
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-20 DOI: 10.2196/70439
Oren Asman, John Torous, Amir Tal

Unlabelled: Generative artificial intelligence (GenAI) shows potential for personalized care, psychoeducation, and even crisis prediction in mental health, yet responsible use requires ethical consideration and deliberation and perhaps even governance. This is the first published theme issue focused on responsible GenAI in mental health. It brings together evidence and insights on GenAI's capabilities, such as emotion recognition, therapy-session summarization, and risk assessment, while highlighting the sensitive nature of mental health data and the need for rigorous validation. Contributors discuss how bias, alignment with human values, transparency, and empathy must be carefully addressed to ensure ethically grounded, artificial intelligence-assisted care. By proposing conceptual frameworks; best practices; and regulatory approaches, including ethics of care and the preservation of socially important humanistic elements, this theme issue underscores that GenAI can complement, rather than replace, the vital role of human empathy in clinical settings. To achieve this, an ongoing collaboration between researchers, clinicians, policy makers, and technologists is essential.

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引用次数: 0
Natural Language Processing and Social Determinants of Health in Mental Health Research: AI-Assisted Scoping Review. 心理健康研究中的自然语言处理和健康的社会决定因素:人工智能辅助范围审查。
IF 4.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-16 DOI: 10.2196/67192
Dmitry A Scherbakov, Nina C Hubig, Leslie A Lenert, Alexander V Alekseyenko, Jihad S Obeid

Background: The use of natural language processing (NLP) in mental health research is increasing, with a wide range of applications and datasets being investigated.

Objective: This review aims to summarize the use of NLP in mental health research, with a special focus on the types of text datasets and the use of social determinants of health (SDOH) in NLP projects related to mental health.

Methods: The search was conducted in September 2024 using a broad search strategy in PubMed, Scopus, and CINAHL Complete. All citations were uploaded to Covidence (Veritas Health Innovation) software. The screening and extraction process took place in Covidence with the help of a custom large language model (LLM) module developed by our team. This LLM module was calibrated and tuned to automate many aspects of the review process.

Results: The screening process, assisted by the custom LLM, led to the inclusion of 1768 studies in the final review. Most of the reviewed studies (n=665, 42.8%) used clinical data as their primary text dataset, followed by social media datasets (n=523, 33.7%). The United States contributed the highest number of studies (n=568, 36.6%), with depression (n=438, 28.2%) and suicide (n=240, 15.5%) being the most frequently investigated mental health issues. Traditional demographic variables, such as age (n=877, 56.5%) and gender (n=760, 49%), were commonly extracted, while SDOH factors were less frequently reported, with urban or rural status being the most used (n=19, 1.2%). Over half of the citations (n=826, 53.2%) did not provide clear information on dataset accessibility, although a sizable number of studies (n=304, 19.6%) made their datasets publicly available.

Conclusions: This scoping review underscores the significant role of clinical notes and social media in NLP-based mental health research. Despite the clear relevance of SDOH to mental health, their underutilization presents a gap in current research. This review can be a starting point for researchers looking for an overview of mental health projects using text data. Shared datasets could be used to place more emphasis on SDOH in future studies.

背景:自然语言处理(NLP)在心理健康研究中的应用正在增加,广泛的应用和数据集正在研究中。目的:本综述旨在总结NLP在心理健康研究中的应用,特别关注文本数据集的类型和健康的社会决定因素(SDOH)在与心理健康相关的NLP项目中的使用。方法:检索于2024年9月在PubMed, Scopus和CINAHL Complete中使用广泛的检索策略进行。所有引文都上传到covid (Veritas Health Innovation)软件。筛选和提取过程是在我们团队开发的定制大型语言模型(LLM)模块的帮助下进行的。这个法学硕士模块经过校准和调整,使审查过程的许多方面自动化。结果:在定制LLM的协助下,筛选过程导致1768项研究被纳入最终审查。回顾的大多数研究(n=665, 42.8%)使用临床数据作为主要文本数据集,其次是社交媒体数据集(n=523, 33.7%)。美国的研究数量最多(n=568, 36.6%),其中抑郁症(n=438, 28.2%)和自杀(n=240, 15.5%)是最常被调查的心理健康问题。传统的人口学变量,如年龄(n=877, 56.5%)和性别(n=760, 49%),通常被提取,而SDOH因素较少被报道,城市或农村状况是最常用的(n=19, 1.2%)。超过一半的引用(n=826, 53.2%)没有提供关于数据集可访问性的明确信息,尽管相当数量的研究(n=304, 19.6%)公开了他们的数据集。结论:本综述强调了临床记录和社交媒体在基于nlp的心理健康研究中的重要作用。尽管SDOH与心理健康有明显的相关性,但它们的利用不足在目前的研究中存在差距。这篇综述可以作为研究人员使用文本数据寻找心理健康项目概述的起点。共享数据集可以在未来的研究中更加重视SDOH。
{"title":"Natural Language Processing and Social Determinants of Health in Mental Health Research: AI-Assisted Scoping Review.","authors":"Dmitry A Scherbakov, Nina C Hubig, Leslie A Lenert, Alexander V Alekseyenko, Jihad S Obeid","doi":"10.2196/67192","DOIUrl":"10.2196/67192","url":null,"abstract":"<p><strong>Background: </strong>The use of natural language processing (NLP) in mental health research is increasing, with a wide range of applications and datasets being investigated.</p><p><strong>Objective: </strong>This review aims to summarize the use of NLP in mental health research, with a special focus on the types of text datasets and the use of social determinants of health (SDOH) in NLP projects related to mental health.</p><p><strong>Methods: </strong>The search was conducted in September 2024 using a broad search strategy in PubMed, Scopus, and CINAHL Complete. All citations were uploaded to Covidence (Veritas Health Innovation) software. The screening and extraction process took place in Covidence with the help of a custom large language model (LLM) module developed by our team. This LLM module was calibrated and tuned to automate many aspects of the review process.</p><p><strong>Results: </strong>The screening process, assisted by the custom LLM, led to the inclusion of 1768 studies in the final review. Most of the reviewed studies (n=665, 42.8%) used clinical data as their primary text dataset, followed by social media datasets (n=523, 33.7%). The United States contributed the highest number of studies (n=568, 36.6%), with depression (n=438, 28.2%) and suicide (n=240, 15.5%) being the most frequently investigated mental health issues. Traditional demographic variables, such as age (n=877, 56.5%) and gender (n=760, 49%), were commonly extracted, while SDOH factors were less frequently reported, with urban or rural status being the most used (n=19, 1.2%). Over half of the citations (n=826, 53.2%) did not provide clear information on dataset accessibility, although a sizable number of studies (n=304, 19.6%) made their datasets publicly available.</p><p><strong>Conclusions: </strong>This scoping review underscores the significant role of clinical notes and social media in NLP-based mental health research. Despite the clear relevance of SDOH to mental health, their underutilization presents a gap in current research. This review can be a starting point for researchers looking for an overview of mental health projects using text data. Shared datasets could be used to place more emphasis on SDOH in future studies.</p>","PeriodicalId":48616,"journal":{"name":"Jmir Mental Health","volume":"12 ","pages":"e67192"},"PeriodicalIF":4.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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