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Digital Health Interventions for Depression and Anxiety in Low- and Middle-Income Countries: Rapid Scoping Review. 低收入和中等收入国家抑郁和焦虑的数字健康干预措施:快速范围审查。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-22 DOI: 10.2196/68296
Leena W Chau, Raymond W Lam, Harry Minas, Kanna Hayashi, Vu Cong Nguyen, John O'Neil
<p><strong>Background: </strong>Low- and middle-income countries (LMICs), which bear a larger proportion of the global mental illness burden, have been disproportionately impacted by the COVID-19 pandemic due to preexisting mental health care system deficiencies. The pandemic has also led to a considerable increase in care delivered through digital mental health interventions (DMHIs), many of which have been adapted from in-person formats. Thus, there is a need to examine their fidelity to the original format along with issues regarding usability and other challenges to and facilitators of their uptake in LMICs. As most DMHIs have been developed in high-income countries, examining their cultural adaptation to LMIC settings is also critical.</p><p><strong>Objective: </strong>The purpose of this research was to conduct a rapid scoping review of the available evidence on DMHIs for depression and anxiety, two of the most common mental disorders, in LMICs.</p><p><strong>Methods: </strong>A rapid scoping review was conducted following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) and processes for rapid reviews by Tricco et al. The PubMed and PsycINFO databases were searched for records published between January 2020 (when COVID-19 was declared a public health emergency) and January 2025 using a search strategy developed in consultation with a liaison librarian. The pandemic accelerated the development and application of DMHIs, and this time frame was used to capture the recent literature that may have incorporated new methods of application. The search strategy was developed across three domains: (1) digital health interventions, (2) depression or anxiety, and (3) LMICs. Data were charted from the final records according to (1) intervention type; (2) discussions on fidelity, usability, and cultural adaptation; and (3) challenges to and facilitators of their uptake in LMICs.</p><p><strong>Results: </strong>A total of 80 records were included in the final analysis, with reasons for exclusion (eg, focused on mental health in general, not being a DMHI, or not focused on LMICs) reported. Six DMHI platforms were identified: (1) mobile app, (2) the web, (3) virtual reality, (4) videoconferencing, (5) telemedicine, and (6) social media. Less than half of the records referenced fidelity (16/80, 20%), usability (29/80, 36%), and cultural adaptation (31/80, 39%). Challenges pertained to the technological system, engagement issues, structural barriers, and concerns regarding privacy and confidentiality. Facilitators included widespread mobile phone use, built-in supervision and training features, and convenience.</p><p><strong>Conclusions: </strong>Despite the opportunities that DMHIs offer for reducing the mental health treatment gap, further work examining and improving their fidelity, usability, and cultural adaptation is required. In addition, various challenges to the uptake of DMHIs in LMIC
背景:在全球精神疾病负担中占较大比例的低收入和中等收入国家(LMICs)由于先前存在的精神卫生保健系统缺陷,受到COVID-19大流行的不成比例的影响。大流行还导致通过数字精神卫生干预措施(DMHIs)提供的护理大幅增加,其中许多干预措施已从面对面的形式改编而来。因此,有必要检查它们对原始格式的忠实程度,以及关于可用性和其他挑战的问题,以及它们在中低收入国家采用的促进因素。由于大多数DMHIs是在高收入国家开发的,因此检查它们对中低收入国家环境的文化适应性也至关重要。目的:本研究的目的是对DMHIs治疗中低收入国家最常见的两种精神障碍抑郁和焦虑的现有证据进行快速范围审查。方法:根据PRISMA-ScR(系统评价和荟萃分析扩展范围评价的首选报告项目)和Tricco等人的快速评价流程进行快速范围评价。在PubMed和PsycINFO数据库中检索了2020年1月(当COVID-19被宣布为公共卫生紧急事件时)至2025年1月期间发表的记录,使用了与联络图书管理员协商制定的搜索策略。大流行加速了DMHIs的开发和应用,并利用这一时间框架收集了可能包含新应用方法的最新文献。搜索策略跨越三个领域:(1)数字健康干预,(2)抑郁或焦虑,以及(3)低收入人群。根据(1)干预类型,从最终记录中绘制数据图表;(2)保真度、可用性和文化适应性的讨论;(3)中低收入国家采用这些方法的挑战和促进因素。结果:共有80份记录被纳入最终分析,并报告了排除原因(例如,关注一般心理健康,不是DMHI,或不关注低收入国家)。确定了六个DMHI平台:(1)移动应用程序,(2)网络,(3)虚拟现实,(4)视频会议,(5)远程医疗和(6)社交媒体。不到一半的记录提到了保真度(16/ 80,20%)、可用性(29/ 80,36%)和文化适应性(31/ 80,39%)。挑战涉及技术系统、参与问题、结构性障碍以及对隐私和机密性的担忧。便利因素包括手机的广泛使用、内置的监督和培训功能以及便利性。结论:尽管DMHIs为缩小心理健康治疗差距提供了机会,但需要进一步研究和提高其保真度、可用性和文化适应性。此外,中低收入国家采用DMHIs的各种挑战,包括背景问题、结构性障碍和隐私问题,必须加以缓解,以避免进一步加剧数字鸿沟。
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引用次数: 0
Exploring the Characteristics of Online Counseling Chat Services for Youth in Europe: Web Search Study. 探索欧洲青年在线咨询聊天服务的特点:网络搜索研究。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-20 DOI: 10.2196/67949
Irati Higuera-Lozano, Virvatuli Uusimäki, Tuuli Pitkänen, Elke Denayer, Alexis Dewaele, Katalin Felvinczi, Lien Goossens, Zsuzsa Kaló, Mónika Rényi, María Cabello

Background: Online counseling chat services are increasingly used by young people worldwide. A growing body of literature supports the use and effectiveness of these services for adolescent mental health. However, there is also a need to provide an overview of the main existing resources to identify unmet needs and gaps in the field.

Objective: This study aims to provide an overview of existing online counseling chat services targeting individuals aged 12-30 years in 4 European countries (Belgium, Finland, Hungary, and Spain), and to identify potential needs and gaps by comparing the collected data with recognized quality standard criteria that define the best practices in the field of counseling.

Methods: A web search was conducted in the 4 participating countries using the same keywords to identify the main chat services. The final selection of chat services was made using a stratified purposive sampling method. A common data extraction database was developed to record information from these websites. Finally, the extracted information was compared against the fulfillment of 7 selected criteria from the Child Helpline International Quality Standards Framework. Additionally, certain chat characteristics were compared with the number of Child Helpline Quality Standard criteria fulfilled.

Results: The search identified a total of 66 service providers offering 71 different chat services. Nongovernmental organizations accounted for more than half of the total service providers42 of 66 (64%). Additional helplines, such as hotlines, were also available through 54 of 66 (82%) service providers. Artificial intelligence tools were incorporated into 6 of 66 (9%) chat services. Differences were observed between countries; for example, the use of volunteers as counselors was predominant in Hungary and Belgium. Topic-specific chat services were common in Belgium and Spain, whereas in Finland and Hungary, chat services generally welcomed a wide range of topics for young people to discuss. Comparisons with Child Helpline International's recommendations revealed some gaps-for example, only 9 of 71 (13%) chat services operated 24 hours a day, and only 10 of 71 (14%) offered interactions in minority groups or foreign languages. Additionally, the use of free social media platforms for chat services was prevalent in some countries, which could compromise users' privacy. Being part of the Child Helpline International consortium was marginally associated with meeting a higher number of standard criteria (β coefficient 1.55; P=.08).

Conclusions: This study provides a comprehensive overview of existing online chat counseling services in 4 European countries. Our findings suggest that some existing chat services for young people could be improved in areas such as accessibility, data security, and the inclusion of vulnerable groups.

背景:全球年轻人越来越多地使用在线咨询聊天服务。越来越多的文献支持这些服务对青少年心理健康的使用和有效性。但是,还需要概述现有的主要资源,以确定该领域未得到满足的需要和差距。目的:本研究旨在对欧洲4个国家(比利时、芬兰、匈牙利和西班牙)现有的针对12-30岁人群的在线咨询聊天服务进行概述,并通过将收集到的数据与定义咨询领域最佳实践的公认质量标准标准进行比较,确定潜在的需求和差距。方法:在4个参与调查的国家使用相同的关键词进行网络搜索,以确定主要的聊天服务。聊天服务的最终选择是采用分层有目的抽样方法进行的。开发了一个通用的数据提取数据库,以记录来自这些网站的信息。最后,将提取的信息与儿童求助热线国际质量标准框架中选定的7个标准的实现情况进行比较。此外,某些聊天特征与满足儿童求助热线质量标准的数量进行了比较。结果:搜索总共确定了66个服务提供商,提供71种不同的聊天服务。非政府组织占全部服务提供者的一半以上,66个中有42个(64%)。66家服务提供商中有54家(82%)提供了额外的帮助热线,如热线。在66项聊天服务中,有6项(9%)使用了人工智能工具。各国之间存在差异;例如,在匈牙利和比利时,主要使用志愿人员担任顾问。特定话题的聊天服务在比利时和西班牙很常见,而在芬兰和匈牙利,聊天服务通常欢迎年轻人讨论广泛的话题。与国际儿童帮助热线的建议相比,发现了一些差距——例如,71个聊天服务中只有9个(13%)每天24小时运行,71个聊天服务中只有10个(14%)提供少数群体或外语互动。此外,一些国家普遍使用免费的社交媒体平台进行聊天服务,这可能会损害用户的隐私。成为国际儿童帮助热线联盟的成员与满足更多的标准标准有轻微的相关性(β系数1.55;P=.08)。结论:本研究提供了4个欧洲国家现有在线聊天咨询服务的全面概述。我们的研究结果表明,针对年轻人的一些现有聊天服务可以在可访问性、数据安全性和弱势群体纳入等方面得到改进。
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引用次数: 0
Feasibility and Acceptability of a Smartphone-Delivered Mindfulness Intervention for Stress Reduction in Adult Singaporeans: Pilot Randomized Controlled Trial. 智能手机正念干预对新加坡成年人减压的可行性和可接受性:随机对照试验。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-19 DOI: 10.2196/77793
Alessandro Sparacio, Jonathan Nicholas Davies, Erin Lee, Jeroen Antonius Johannes Schmitt
<p><strong>Background: </strong>Fully decentralized self-administered mindfulness interventions show promise for stress reduction, but rigorous evaluations of their feasibility, acceptability, and effectiveness using both self-report and physiological measures remain limited. In Singapore, where mental health concerns rank as the top health care priority (46%), ahead of cancer (38%) and stress-related issues (35%), accessible and scalable interventions are urgently needed to address the significant economic burden of mental health conditions.</p><p><strong>Objective: </strong>This study aimed to evaluate a decentralized, 3-day self-administered mindfulness intervention with minimal supervision, compared with a sham control in Singaporean adults, examining effects on self-reported and physiologically measured stress responses. The inclusion of a sham control condition was intended to disentangle mindfulness-specific effects from demand characteristics and expectation effects, addressing a critical methodological gap in digital mindfulness research.</p><p><strong>Methods: </strong>This was a purely smartphone-based, decentralized pilot trial with no face-to-face components. Participants were recruited using web-based methods and, after providing informed consent, 60 adults were randomized to either a mindfulness intervention or a structurally matched sham control. The daily 10-minute mindfulness sessions guided participants to focus on present-moment breath and body sensations, while the sham control omitted a focus on present-moment awareness. Outcomes were assessed remotely, using self-report questionnaires (State-Trait Anxiety Inventory-6) and physiological data from smartphone-based photoplethysmography (heart rate variability; HRV). The study incorporated three methodological innovations: (1) a structurally equivalent sham control to match expectancy and credibility, (2) remote collection of HRV as an objective physiological biomarker, and (3) full decentralization allowing unsupervised multiplatform delivery. Feasibility was evaluated through recruitment, retention rates, and data quality. Acceptability was assessed through quantitative ratings and qualitative feedback.</p><p><strong>Results: </strong>The study demonstrated excellent feasibility, with near-perfect retention (59/60, 98.3%) and moderate HRV data quality (231/331, 69.8% valid signals). Acceptability ratings were high (mean 4.17, SD 0.53), with comfort/engagement receiving the highest scores (mean 4.27, SD 0.57) on a 5-point scale, exceeding established usability benchmarks for digital health interventions. Qualitative feedback identified technical challenges (HRV instability and device overheating) and scheduling difficulties. While Bayesian analyses did not detect significant group differences in stress reduction (Bayes factor<sub>10</sub> [BF<sub>10</sub>]=0.03) or HRV improvement (BF<sub>10</sub>=0.2), both groups showed significant stress reductions (BF<sub>10</sub>=3.01×10<
背景:完全分散的自我管理的正念干预显示出减轻压力的希望,但使用自我报告和生理测量对其可行性、可接受性和有效性的严格评估仍然有限。在新加坡,心理健康问题被列为医疗保健的首要问题(46%),排在癌症(38%)和压力相关问题(35%)之前,迫切需要可获得和可扩展的干预措施,以解决心理健康状况带来的重大经济负担。目的:本研究旨在评估分散的、为期3天的自我管理的正念干预,在最小的监督下,与假控制相比,在新加坡成年人中,检查对自我报告和生理测量的应激反应的影响。纳入假控制条件的目的是将正念特定效应与需求特征和期望效应分开,解决数字正念研究中一个关键的方法学空白。方法:这是一个纯粹基于智能手机的分散试点试验,没有面对面的组件。参与者使用基于网络的方法招募,在提供知情同意后,60名成年人被随机分为正念干预组和结构匹配的假对照组。每天10分钟的正念训练引导参与者专注于当下的呼吸和身体感觉,而假对照组忽略了当下意识的关注。结果通过自我报告问卷(状态-特质焦虑量表-6)和基于智能手机的光容积脉搏图(心率变异性;HRV)的生理数据进行远程评估。该研究结合了三个方法创新:(1)结构等效的假对照,以匹配期望和可信度;(2)远程收集HRV作为客观生理生物标志物;(3)完全分散,允许无监督的多平台交付。可行性通过招聘、保留率和数据质量进行评估。通过定量评分和定性反馈来评估可接受性。结果:该研究具有良好的可行性,保留率接近完美(59/60,98.3%),HRV数据质量适中(231/ 331,69.8%有效信号)。可接受性评分很高(平均4.17,标准差0.53),在5分制中,舒适度/参与度得分最高(平均4.27,标准差0.57),超过了数字健康干预措施的既定可用性基准。定性反馈确定了技术挑战(HRV不稳定和设备过热)和调度困难。虽然贝叶斯分析没有发现应激减轻(贝叶斯因子10 [BF10]=0.03)或HRV改善(BF10=0.2)方面的显著组间差异,但两组均表现出显著的应激减轻(BF10=3.01×106),这表明观察到的益处可能源于两种干预措施共同的非特异性因素。结论:本研究论证了(1)采用多模态评估进行全分散正念试验的可行性,(2)混合方法可接受性评估的价值,以及(3)确定未来试验所需的关键技术和控制条件改进。通过改善控制条件和客观测量来解决方法上的局限性,本研究为更严格地研究正念特定效果提供了基础。试验注册:ClinicalTrials.gov NCT06765889;https://clinicaltrials.gov/study/NCT06765889。
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引用次数: 0
The Ability of AI Therapy Bots to Set Limits With Distressed Adolescents: Simulation-Based Comparison Study. 人工智能治疗机器人对痛苦青少年设定限制的能力:基于模拟的比较研究。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-18 DOI: 10.2196/78414
Andrew Clark

Background: Recent developments in generative artificial intelligence (AI) have introduced the general public to powerful, easily accessible tools, such as ChatGPT and Gemini, for a rapidly expanding range of uses. Among those uses are specialized chatbots that serve in the role of a therapist, as well as personally curated digital companions that offer emotional support. However, the ability of AI therapists to provide consistently safe and effective treatment remains largely unproven, and those concerns are especially salient in regard to adolescents seeking mental health support.

Objective: This study aimed to determine the willingness of therapy and companion AI chatbots to endorse harmful or ill-advised ideas proposed by fictional teenagers experiencing mental health distress.

Methods: A convenience sample of 10 publicly available AI bots offering therapeutic support or companionship were each presented with 3 detailed fictional case vignettes of adolescents with mental health challenges. Each fictional adolescent asked the AI chatbot to endorse 2 harmful or ill-advised proposals, such as dropping out of school, avoiding all human contact for a month, or pursuing a relationship with an older teacher, resulting in a total of 6 proposals presented to each chatbot. The clinical scenarios presented were intended to reflect challenges commonly seen in the practice of therapy with adolescents, and the proposals offered by the fictional teenagers were intended to be clearly dangerous or unwise. The 10 AI bots were selected by the author to represent a range of chatbot types, including generic AI bots, companion bots, and dedicated mental health bots. Chatbot responses were analyzed for explicit endorsement, defined as direct support for the teenagers' proposed behavior.

Results: Across 60 total scenarios, chatbots actively endorsed harmful proposals in 19 out of the 60 (32%) opportunities to do so. Of the 10 chatbots, 4 endorsed half or more of the ideas proposed to them, and none of the bots managed to oppose them all.

Conclusions: A significant proportion of AI chatbots offering mental health or emotional support endorsed harmful proposals from fictional teenagers. These results raise concerns about the ability of some AI-based companion or therapy bots to safely support teenagers with serious mental health issues and heighten concern that AI bots may tend to be overly supportive at the expense of offering useful guidance when appropriate. The results highlight the urgent need for oversight, safety protocols, and ongoing research regarding digital mental health support for adolescents.

背景:生成式人工智能(AI)的最新发展向公众介绍了功能强大、易于使用的工具,如ChatGPT和Gemini,其用途范围迅速扩大。这些用途包括充当治疗师角色的专门聊天机器人,以及提供情感支持的个人策划的数字伴侣。然而,人工智能治疗师提供持续安全和有效治疗的能力在很大程度上仍未得到证实,而这些担忧在寻求心理健康支持的青少年方面尤为突出。目的:本研究旨在确定治疗和陪伴人工智能聊天机器人是否愿意支持虚构的经历心理健康困扰的青少年提出的有害或不明智的想法。方法:选取10个公开提供治疗支持或陪伴的人工智能机器人作为方便样本,每个机器人都有3个详细的虚构案例,这些案例都是有心理健康挑战的青少年。每个虚构的青少年都要求人工智能聊天机器人支持2个有害或不明智的提议,比如辍学、一个月不与人接触、或与一位年长的老师谈恋爱,结果每个聊天机器人总共收到了6个提议。所呈现的临床场景旨在反映青少年治疗实践中常见的挑战,而虚构的青少年提出的建议显然是危险或不明智的。作者选择了10个人工智能机器人来代表一系列聊天机器人类型,包括通用人工智能机器人、伴侣机器人和专用心理健康机器人。对聊天机器人的回应进行分析,以获得明确的支持,定义为对青少年提议行为的直接支持。结果:在60个场景中,聊天机器人在60个机会中有19个(32%)积极支持有害的提议。在这10个聊天机器人中,有4个支持了一半或更多的提议,没有一个机器人能完全反对这些提议。结论:在提供心理健康或情感支持的人工智能聊天机器人中,有很大一部分支持虚构的青少年提出的有害建议。这些结果引发了人们的担忧,即一些基于人工智能的伴侣或治疗机器人是否有能力安全地支持有严重心理健康问题的青少年,并加剧了人们的担忧,即人工智能机器人可能倾向于过度支持,而不是在适当的时候提供有用的指导。研究结果强调了对青少年数字心理健康支持的监督、安全协议和持续研究的迫切需要。
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引用次数: 0
Mindful Nonreactivity, Anxiety, Depression, and Perceived Stress as Mediators of the Mindfulness Virtual Community Intervention-Pathways to Enhance Mental Health in University Students: Secondary Evaluation of Two Randomized Controlled Trials With Student Participants. 正念无反应性、焦虑、抑郁和感知压力作为正念虚拟社区干预的中介——促进大学生心理健康的途径:两项随机对照试验的二次评价。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-18 DOI: 10.2196/65853
Meysam Pirbaglou, Christo El Morr, Farah Ahmad, Paul Ritvo

Background: Mindfulness-based interventions (MBIs) are widely used in mental health promotion and treatment. Despite widespread evidence of effectiveness with different populations and delivery modes, there are sparse findings concerning the mechanisms of action in MBIs.

Objective: The objective of this paper was to understand the mediators of the Mindfulness Virtual Community (MVC) intervention, an 8-week, multicomponent, online mindfulness and cognitive-behavioral therapy (M-CBT) intervention, based on a secondary evaluation of 2 randomized controlled trials (RCTs) with student participants.

Methods: Mediation analysis, using structural equation modeling, was used to assess direct and indirect relationships between study group (ie, intervention or wait list control) and outcomes. Consistent with the intervention's theoretical perspective and direct effects paths, a model was specified to evaluate whether mindful nonreactivity, as evaluated by the 5-factor mindfulness questionnaire, mediated the effect of MVC intervention on anxiety and depression (as symptom-driven outcomes), and perceived stress and quality of life (as functional outcomes). The model included additional mediating paths for perceived stress through anxiety and depression, and for quality of life through anxiety, depression, and perceived stress. The model was thereafter extended, adjusting for pre-intervention differences in mindfulness (ie, observing, describing, activity with awareness, nonjudgment, and nonreactivity) facets.

Results: Direct (nonmediated) effects indicated statistically significant differences at 8 weeks between the MVC and waitlist control (WLC) groups on depression (-1.72; P=.002), anxiety (-3.40; P=.001), perceived stress (-2.44; P<.001), quality of life (4.31; P=.005), and the nonreactivity facet of mindfulness (1.63; P<.001), in favor of the MVC intervention. Mediation analysis supported the mediating role of the nonreactivity facet of mindfulness, depression, anxiety, and perceived stress through single and sequential mediation paths. Results indicated good fit characteristics for the main (comparative fit index [CFI]=.99; root-mean-square error of approximation [RMSEA]=.05; standardized root-mean-square residual [SRMR]=.05) and extended (CFI=.99; RMSEA=.04; SRMR=.04) models.

Conclusions: This research underscores the importance of mindful nonreactivity, depression, and anxiety as key mediators of MVC intervention benefits.

背景:正念干预(MBIs)在心理健康促进和治疗中得到广泛应用。尽管广泛的证据表明在不同的人群和递送模式中有效,但关于mbi的作用机制的发现很少。目的:本文旨在通过对两项随机对照试验(rct)的二次评价,了解正念虚拟社区(MVC)干预的中介因素,这是一项为期8周的多组分在线正念和认知行为治疗(M-CBT)干预。方法:采用结构方程模型进行中介分析,评估实验组(即干预或等候名单对照)与结局的直接和间接关系。与干预的理论观点和直接效应路径一致,我们指定了一个模型来评估正念无反应性是否介导MVC干预对焦虑和抑郁(作为症状驱动的结果),以及感知压力和生活质量(作为功能结果)的影响。该模型包括通过焦虑和抑郁感知压力的额外中介路径,以及通过焦虑、抑郁和感知压力影响生活质量的额外中介路径。该模型随后被扩展,调整了正念(即观察、描述、有意识的活动、非判断和非反应)方面的干预前差异。结果:直接(非介导)效应显示,在8周时,MVC组和等候名单对照组(WLC)在抑郁(-1.72;P= 0.002)、焦虑(-3.40;P= 0.001)、感知压力(-2.44;P)方面存在统计学差异。结论:本研究强调了正心无反应性、抑郁和焦虑作为MVC干预益处的关键中介的重要性。
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引用次数: 0
Placebo, Nocebo, and Machine Learning: How Generative AI Could Shape Patient Perception in Mental Health Care. 安慰剂、反安慰剂和机器学习:生成式人工智能如何在精神卫生保健中塑造患者的感知。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-15 DOI: 10.2196/78663
Charlotte Blease

Unlabelled: The emergence of generative artificial intelligence (GenAI) in clinical settings-particularly in health documentation and communication-presents a largely unexplored but potentially transformative force in shaping placebo and nocebo effects. These psychosocial phenomena are especially potent in mental health care, where outcomes are closely tied to patients' expectations, perceived provider competence, and empathy. Drawing on conceptual understanding of placebo and nocebo effects and the latest research, this Viewpoint argues that GenAI may amplify these effects, both positive and negative. Through tone, assurance, and even the rapidity of responses, GenAI-generated text-either co-written with clinicians or peers, or fully automated-could influence patient perceptions in ways that mental health clinicians may not currently fully anticipate. When embedded in clinician notes or patient-facing summaries, AI language may strengthen expectancies that underlie placebo effects, or conversely, heighten nocebo effects through subtle cues, inaccuracies, or potentially via loss of human nuance. This article explores the implications of AI-mediated clinical communication particularly in mental health care, emphasizing the importance of transparency, ethical oversight, and psychosocial awareness as these technologies evolve.

未标记:生殖人工智能(GenAI)在临床环境中的出现——特别是在健康记录和交流方面——在塑造安慰剂和反安慰剂效应方面呈现出一种很大程度上未被探索但潜在的变革力量。这些社会心理现象在精神卫生保健中尤其有效,其结果与患者的期望、感知到的提供者能力和同理心密切相关。根据对安慰剂和反安慰剂效应的概念理解和最新研究,本观点认为GenAI可能会放大这些效应,无论是积极的还是消极的。通过语气、保证,甚至反应的速度,genai生成的文本——无论是与临床医生或同行共同编写的,还是完全自动化的——都可能以心理健康临床医生目前可能无法完全预料到的方式影响患者的看法。当嵌入到临床医生笔记或面向患者的总结中时,人工智能语言可能会加强安慰剂效应背后的预期,或者相反,通过微妙的提示、不准确或潜在地通过失去人类细微差别来增强反安慰剂效应。本文探讨了人工智能介导的临床沟通的影响,特别是在精神卫生保健方面,强调了随着这些技术的发展,透明度、伦理监督和社会心理意识的重要性。
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引用次数: 0
An Examination of Generative AI Response to Suicide Inquires: Content Analysis. 生成式人工智能对自杀询问的回应:内容分析。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-14 DOI: 10.2196/73623
Laurie O Campbell, Kathryn Babb, Glenn W Lambie, B Grant Hayes

Background: Generative artificial intelligence (AI) chatbots are an online source of information consulted by adolescents to gain insight into mental health and wellness behaviors. However, the accuracy and content of generative AI responses to questions related to suicide have not been systematically investigated.

Objective: This study aims to investigate general (not counseling-specific) generative AI chatbots' responses to questions regarding suicide.

Methods: A content analysis was conducted of the responses of generative AI chatbots to questions about suicide. In phase 1 of the study, generative chatbots examined include: (1) Google Bard or Gemini; (2) Microsoft Bing or CoPilot; (3) ChatGPT 3.5 (OpenAI); and (4) Claude (Anthropic). In phase 2 of the study, additional generative chatbot responses were analyzed, which included Google Gemini, Claude 2 (Anthropic), xAI Grok 2, Mistral AI, and Meta AI (Meta Platforms). The two phases occurred a year apart.

Results: Findings included a linguistic analysis of the authenticity and tone within the responses using the Linguistic Inquiry and Word Count program. There was an increase in the depth and accuracy of the responses between phase 1 and phase 2 of the study. There is evidence that the responses by the generative AI chatbots were more comprehensive and responsive during phase 2 than phase 1. Specifically, the responses were found to provide more information regarding all aspects of suicide (eg, signs of suicide, lethality, resources, and ways to support those in crisis). Another difference noted in the responses between the first and second phases was the emphasis on the 988 suicide hotline number.

Conclusions: While this dynamic information may be helpful for youth in need, the importance of individuals seeking help from a trained mental health professional remains. Further, generative AI algorithms related to suicide questions should be checked periodically to ensure best practices regarding suicide prevention are being communicated.

背景:生成式人工智能(AI)聊天机器人是青少年了解心理健康和健康行为的在线信息来源。然而,生成式人工智能对自杀相关问题的回答的准确性和内容尚未得到系统的调查。目的:本研究旨在调查一般(非特定咨询)生成AI聊天机器人对自杀问题的反应。方法:对生成式AI聊天机器人对自杀问题的回答进行内容分析。在研究的第一阶段,研究的生成式聊天机器人包括:(1)b谷歌Bard或Gemini;(2)微软必应或CoPilot;(3) ChatGPT 3.5 (OpenAI);(4)克劳德(Anthropic)。在研究的第二阶段,分析了其他生成式聊天机器人的响应,包括谷歌Gemini、Claude 2 (Anthropic)、xAI Grok 2、Mistral AI和Meta AI (Meta Platforms)。这两个阶段相隔一年。结果:研究结果包括使用语言调查和字数统计程序对回答的真实性和语气进行语言分析。在研究的第一阶段和第二阶段之间,反应的深度和准确性有所增加。有证据表明,生成式人工智能聊天机器人在第二阶段的反应比第一阶段更全面,反应更灵敏。具体来说,我们发现这些回答提供了更多关于自杀各个方面的信息(例如,自杀的迹象、致命性、资源和支持处于危机中的人的方法)。在第一阶段和第二阶段的回应中,另一个不同之处是对988自杀热线号码的强调。结论:虽然这些动态信息可能对有需要的青少年有所帮助,但个人向训练有素的心理健康专业人员寻求帮助的重要性仍然存在。此外,应定期检查与自杀问题相关的生成人工智能算法,以确保传达有关自杀预防的最佳做法。
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引用次数: 0
Anticipation and Motivation as Predictors of Leisure and Social Enjoyment and Engagement in Young People With Depression Symptoms: Ecological Momentary Assessment Study. 预期和动机作为青少年抑郁症状的休闲、社会享受和参与的预测因子:生态瞬时评估研究。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-13 DOI: 10.2196/74427
Angad Sahni, Ciara McCabe
<p><strong>Background: </strong>Participating in leisure and social activities can alleviate depression symptoms, yet effective strategies to enhance enjoyment and maintain long-term engagement remain scarce. Gaining insight into the reward subcomponents that influence daily experiences and drive behavior could uncover novel targets for intervention.</p><p><strong>Objective: </strong>This study examines the role of anticipation and motivation in predicting enjoyment and engagement in leisure activities and socializing among young people, and how these relationships are moderated by depression severity, using intensive longitudinal ecological momentary assessments.</p><p><strong>Methods: </strong>Participants (N=80; mean age 20, SD 2.3 years) used the Psymate2 smartphone app to report mood, enjoyment, current and anticipated activities, and social company 7 times daily for 6 days. Activity categories were relaxation, exercise, other leisure, work or school, studying, chores, shopping, hygiene, eating or drinking, and traveling, and company categories were partner, friends, family, colleagues, acquaintances, strangers, and nobody. Anticipation (anticipatory pleasure and expectation) and motivation (interest and preference) for upcoming activities were rated on Likert scales. Participants were grouped by depression severity, measured using the Mood and Feelings Questionnaire (MFQ): high (HD, MFQ ≥27, N=42), moderate (MD, MFQ 16-27, N=16), and low, that is, controls (C, MFQ ≤16, N=22). Totally, 2316 assessments met inclusion criteria.</p><p><strong>Results: </strong>Leisure activities (relaxation, exercise, and other leisure) and social company (partner, friends, and family) were rated most enjoyable across all groups. Higher depression symptoms were associated with reduced enjoyment of studying (β=-.03; P=.005), eating or drinking (β=-.02; P=.02), and other leisure activities (β=-.02; P=.02), as well as lower engagement in work or school (β=-.26; P=.02) and hygiene (β=-.08; P=.03), and increased inactivity (β=.17; P=.03). Time-lagged multilevel analyses showed that anticipatory pleasure predicted greater enjoyment across all activities (β=.12; P<.001) and social contexts (β=.33; P<.001), with consistent effects in controls and the high depression group. However, the more an activity was expected to happen, the less enjoyment was experienced in the whole sample (β=-.006; P=.001) and high depression group (β=-.008; P=.001) but not controls. Anticipatory pleasure and motivation (preference) predicted leisure engagement in the whole sample (β=.19, P=.003; β=.11, P<.001) and controls (β=.43, P=.005; β=.17, P=.048) but not the depression groups. Anticipatory pleasure predicted only leisure engagement in the high depression group when predictors and outcomes were matched for the same event (β=.22; P=.001). Anticipatory pleasure predicted social engagement in the whole sample (β=.095; P=.047) and controls (β=.34; P=.003), but not in the depression groups.</
背景:参与休闲和社交活动可以缓解抑郁症状,但提高乐趣和保持长期参与的有效策略仍然缺乏。深入了解影响日常体验和驱动行为的奖励子成分,可以发现新的干预目标。目的:本研究通过深入的纵向生态瞬时评估,探讨了预期和动机在预测年轻人享受和参与休闲活动和社交中的作用,以及这些关系如何受到抑郁严重程度的调节。方法:参与者(N=80;平均年龄20岁,SD 2.3岁)使用Psymate2智能手机应用程序报告情绪,享受,当前和预期的活动,以及社交公司,每天7次,持续6天。活动类别为放松、锻炼、其他休闲、工作或学校、学习、家务、购物、卫生、饮食和旅行,公司类别为伙伴、朋友、家人、同事、熟人、陌生人和没有人。对即将到来的活动的预期(预期的快乐和期望)和动机(兴趣和偏好)用李克特量表进行评分。参与者根据抑郁严重程度进行分组,使用心境与感受问卷(MFQ)测量:高(HD, MFQ≥27,N=42),中度(MD, MFQ 16-27, N=16),低,即对照组(C, MFQ≤16,N=22)。共有2316项评估符合纳入标准。结果:休闲活动(放松、锻炼和其他休闲活动)和社交陪伴(伴侣、朋友和家人)在所有人群中被评为最令人愉快的。抑郁症状加重与学习乐趣降低相关(β=- 0.03;P= 0.005),饮食(β=- 0.02;P=.02),其他休闲活动(β=-.02;P=.02),以及较低的工作或学习投入(β=- 0.26;P= 0.02)和卫生(β=- 0.08;P=.03),不运动增加(β=.17;P = 03)。滞后多水平分析表明,预期快乐预示着所有活动中更大的享受(β= 0.12;结论:这些发现强调了预期快乐和内在动机在塑造年轻人参与和享受日常活动中的重要性。结构化的或外部驱动的环境可能会抑制享受——尤其是在抑郁症患者中——强调需要针对预期和动机的新干预措施,以增强对奖励活动的持续参与,从而改善抑郁症患者的幸福感。
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引用次数: 0
The Cost-Effectiveness of Digitally Supported Mental Well-Being Prevention and Promotion Targeting Nonclinical Adult Populations: Systematic Review. 针对非临床成人人群的数字支持心理健康预防和促进的成本效益:系统评价。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-11 DOI: 10.2196/72458
Sara Claes, Fleur Van De Wielle, Els Clays, Lieven Annemans

Background: In recent years, policymakers worldwide have been increasingly concerned with promoting public mental well-being. While digitally supported well-being interventions seem effective in general nonclinical populations, their cost-effectiveness remains unclear.

Objective: This study aims to systematically synthesize evidence on the cost-effectiveness of digitally supported mental well-being interventions targeting the general population or adults with subclinical mental health symptoms.

Methods: PubMed, Embase, Scopus, and Web of Science were systematically searched for health economic or cost-minimization studies. Eligibility criteria included interventions in the general population or adults showing risk factors or subclinical mental health symptoms, with at least 1 digital component. Study quality was comprehensively assessed using the Consensus Health Economic Criteria list.

Results: Of 3455 records identified after duplicate removal, 12 studies were included: 3 studies evaluated universal prevention, 3 investigated selective prevention, and 6 covered indicated prevention. Six studies applied a societal perspective. Incremental cost-utility ratios were reported in 6 of the included studies and varied from dominant to €18,710 (US $ 23,185) per quality-adjusted life year. In general, digitally supported well-being interventions in nonclinical adults, and particularly indicated prevention strategies, seemed to generate improved health outcomes at lower costs from a societal perspective. The quality appraisal highlighted several shortcomings of the available literature.

Conclusions: Overall, the use of digital tools for mental well-being prevention and promotion in nonclinical adult populations has the potential to be cost-effective. Nevertheless, to adequately guide policymaking, more evidence is still needed. Future studies should ensure valid argumentation for the applied time horizon and perspective, alongside rigorous sensitivity analyses in accordance with best practices to improve cost-effectiveness evidence. Furthermore, assessment methods more sensitive to changes in well-being such as the EQ Health and Well-being instrument could be considered.

背景:近年来,全球决策者越来越关注促进公众心理健康。虽然数字支持的福祉干预措施似乎对一般非临床人群有效,但其成本效益仍不清楚。目的:本研究旨在系统地综合针对普通人群或有亚临床心理健康症状的成年人的数字支持心理健康干预的成本效益证据。方法:系统地检索PubMed、Embase、Scopus和Web of Science中有关卫生经济或成本最小化的研究。入选标准包括在普通人群或表现出危险因素或亚临床精神健康症状的成年人中进行干预,至少有1个数字成分。使用共识健康经济标准清单对研究质量进行综合评估。结果:在去除重复后确定的3455份记录中,纳入了12项研究:3项研究评估普遍预防,3项研究评估选择性预防,6项研究涵盖指示性预防。六项研究应用了社会视角。在纳入的6项研究中报告了增量成本效用比,每个质量调整生命年的成本效用比从占主导地位到18,710欧元(23,185美元)不等。总的来说,从社会角度来看,数字支持的非临床成年人福祉干预措施,特别是指示的预防策略,似乎以较低的成本产生了改善的健康结果。质量评价突出了现有文献的几个缺点。结论:总体而言,在非临床成年人群中使用数字工具预防和促进心理健康具有成本效益的潜力。然而,要充分指导政策制定,还需要更多的证据。未来的研究应确保对适用的时间范围和前景进行有效论证,同时根据最佳做法进行严格的敏感性分析,以提高成本效益证据。此外,可以考虑采用对幸福感变化更敏感的评估方法,如情商健康和幸福感工具。
{"title":"The Cost-Effectiveness of Digitally Supported Mental Well-Being Prevention and Promotion Targeting Nonclinical Adult Populations: Systematic Review.","authors":"Sara Claes, Fleur Van De Wielle, Els Clays, Lieven Annemans","doi":"10.2196/72458","DOIUrl":"10.2196/72458","url":null,"abstract":"<p><strong>Background: </strong>In recent years, policymakers worldwide have been increasingly concerned with promoting public mental well-being. While digitally supported well-being interventions seem effective in general nonclinical populations, their cost-effectiveness remains unclear.</p><p><strong>Objective: </strong>This study aims to systematically synthesize evidence on the cost-effectiveness of digitally supported mental well-being interventions targeting the general population or adults with subclinical mental health symptoms.</p><p><strong>Methods: </strong>PubMed, Embase, Scopus, and Web of Science were systematically searched for health economic or cost-minimization studies. Eligibility criteria included interventions in the general population or adults showing risk factors or subclinical mental health symptoms, with at least 1 digital component. Study quality was comprehensively assessed using the Consensus Health Economic Criteria list.</p><p><strong>Results: </strong>Of 3455 records identified after duplicate removal, 12 studies were included: 3 studies evaluated universal prevention, 3 investigated selective prevention, and 6 covered indicated prevention. Six studies applied a societal perspective. Incremental cost-utility ratios were reported in 6 of the included studies and varied from dominant to €18,710 (US $ 23,185) per quality-adjusted life year. In general, digitally supported well-being interventions in nonclinical adults, and particularly indicated prevention strategies, seemed to generate improved health outcomes at lower costs from a societal perspective. The quality appraisal highlighted several shortcomings of the available literature.</p><p><strong>Conclusions: </strong>Overall, the use of digital tools for mental well-being prevention and promotion in nonclinical adult populations has the potential to be cost-effective. Nevertheless, to adequately guide policymaking, more evidence is still needed. Future studies should ensure valid argumentation for the applied time horizon and perspective, alongside rigorous sensitivity analyses in accordance with best practices to improve cost-effectiveness evidence. Furthermore, assessment methods more sensitive to changes in well-being such as the EQ Health and Well-being instrument could be considered.</p>","PeriodicalId":48616,"journal":{"name":"Jmir Mental Health","volume":"12 ","pages":"e72458"},"PeriodicalIF":5.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Telepresence Among Patients and Psychotherapists in the Actor-Partner Interdependence Model: Longitudinal Observational Study of 20 Dyads From a Randomized Trial on Video Consultations in Primary Care. 在行动者-伴侣相互依赖模型中,患者和心理治疗师的远程在场发展:来自初级保健视频咨询随机试验的20对纵向观察研究。
IF 5.8 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-08-11 DOI: 10.2196/70415
Markus W Haun, Deborah van Eickels, Isabella Stephan, Justus Tönnies, Mechthild Hartmann, Michel Wensing, Joachim Szecsenyi, Andrea Icks, Hans-Christoph Friederich

Background: The COVID-19 pandemic has accelerated the adoption of video consultations in mental health care, highlighting the importance of therapeutic alliances for successful treatment outcomes in both face-to-face and web-based settings. Telepresence, the sense of being present with the mental health specialist (MHS) rather than feeling remote, is a critical component of building a strong therapeutic alliance in video consultations. While patients often report high telepresence levels, MHSs express concerns about whether video consultations can replicate the quality of face-to-face interactions. Despite its importance, research on telepresence development in MHSs over time and the dyadic interplay between patients and MHSs remains limited.

Objective: This study aimed to evaluate the mutual influence within patient-MHS dyads on telepresence development during video consultations, using data from a randomized controlled trial assessing the feasibility of video consultations for depression and anxiety disorders in primary care.

Methods: The study included 22 patient-MHS dyads (22 patients, 4 MHSs). Telepresence was measured using the Telepresence in Videoconference Scale. Dyadic data were analyzed using the actor-partner interdependence model with a distinguishable dyad structural equation model. Actor effects refer to the impact of an individual's telepresence at time point 1 (T1) on their telepresence at time point 2 (T2), while partner effects represent the influence of one party's telepresence at T1 on the other's telepresence at T2. Sensitivity analyses excluded data from individual MHSs to account for their unique effects.

Results: A significant actor effect for MHSs (P<.001) indicated a high temporal stability of telepresence between T1 and T2. In contrast, the actor effect for patients was not statistically significant, suggesting a greater variability between T1 and T2. No significant partner effects for both patients and MHSs were observed, suggesting no mutual influence between dyad members. Age was a significant covariate for telepresence in both groups.

Conclusions: Consistent with prior findings, MHSs experienced increased telepresence over time, whereas patients reported high telepresence levels from the start of therapy. The lack of dyadic influence highlights the need for further exploration into factors affecting telepresence development, such as age, technical proficiency, and prior treatment experience. Future studies with larger samples and more sessions are necessary to enhance the generalizability of these findings and to optimize the use of video consultations in mental health care.

背景:2019冠状病毒病大流行加速了精神卫生保健中视频咨询的采用,突出了治疗联盟在面对面和网络环境中对成功治疗结果的重要性。远程呈现,即与精神卫生专家(MHS)在一起而不是感到遥远的感觉,是在视频咨询中建立强有力的治疗联盟的关键组成部分。虽然患者经常报告高远程呈现水平,但mhs对视频咨询能否复制面对面互动的质量表示担忧。尽管它很重要,但随着时间的推移,关于远程呈现在mss中的发展以及患者与mss之间的二元相互作用的研究仍然有限。目的:本研究旨在通过一项评估初级保健中抑郁症和焦虑症视频会诊可行性的随机对照试验的数据,评估患者- mhs对视频会诊中远程呈现发展的相互影响。方法:纳入22例mhs患者(22例,4例mhs)。用《视频会议网真量表》测量网真。采用可区分的二元结构方程模型对二元数据进行分析。行动者效应是指个体在时间点1 (T1)的临场感对其在时间点2 (T2)的临场感的影响,而伙伴效应是指一方在T1时刻的临场感对另一方在T2时刻的临场感的影响。敏感性分析排除了来自单个mhs的数据,以解释其独特的影响。结论:与先前的研究结果一致,随着时间的推移,mhs的远程临场感增加,而患者从治疗开始就报告了高的远程临场感水平。由于缺乏二元影响,需要进一步探索影响网真发展的因素,如年龄、技术熟练程度和先前的治疗经验。未来有必要进行更大样本和更多会话的研究,以增强这些发现的普遍性,并优化视频咨询在精神卫生保健中的应用。
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引用次数: 0
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Jmir Mental Health
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