Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.043
Vaishnavi Ganesan, Mrunal V. Kesari, Y. Patil, Indranil Bhattacharya
Gastrointestinal Stromal Tumors (GIST) is a tumor of mesenchymal origin in the digestive tract, arising from Interstitial cells of Cajal. Majorly, they are an incidental finding in people of older age group (>60 years) with very rare bone metastasis. Our aim is to understand the role of genetic mutations in metastasis of GIST and coexistence of other malignancy in the same patient. We present an unusual case of a 75-year-old male with jejunal GIST, managed with resection of the tumor and imatinib, who 15 years later presented with subsequent liver, rare femoral head metastases and coexisting Renal Cell Carcinoma in left kidney. GIST cases can be associated with different syndromes and malignancies. This necessitates additional work up and long term follow up.
胃肠间质瘤（GIST）是消化道中的一种间质来源肿瘤，由卡贾尔间质细胞（Interstitial cells of Cajal）产生。胃肠间质瘤主要是老年人（60 岁以上）的偶然发现，骨转移非常罕见。我们的目的是了解基因突变在 GIST 转移中的作用，以及同一患者同时患有其他恶性肿瘤的情况。我们介绍了一例不寻常的病例，患者是一名75岁的男性，患有空肠GIST，曾接受肿瘤切除术和伊马替尼治疗，15年后出现肝转移、罕见的股骨头转移和左肾肾细胞癌并存。GIST 病例可能伴有不同的综合征和恶性肿瘤。这就需要进行额外的检查和长期随访。
{"title":"Metastatic GIST with a TWIST of RCC: A case report","authors":"Vaishnavi Ganesan, Mrunal V. Kesari, Y. Patil, Indranil Bhattacharya","doi":"10.18231/j.ijpo.2024.043","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.043","url":null,"abstract":"Gastrointestinal Stromal Tumors (GIST) is a tumor of mesenchymal origin in the digestive tract, arising from Interstitial cells of Cajal. Majorly, they are an incidental finding in people of older age group (>60 years) with very rare bone metastasis. Our aim is to understand the role of genetic mutations in metastasis of GIST and coexistence of other malignancy in the same patient. We present an unusual case of a 75-year-old male with jejunal GIST, managed with resection of the tumor and imatinib, who 15 years later presented with subsequent liver, rare femoral head metastases and coexisting Renal Cell Carcinoma in left kidney. GIST cases can be associated with different syndromes and malignancies. This necessitates additional work up and long term follow up.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"36 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microsatellite instability (MSI) and mismatch repair (MMR) deficiency are important biomarkers in colorectal cancer (CRC) that have clinical implications for patient management and treatment. MMR deficiency can lead to MSI, which is characterized by alterations in the length of microsatellite DNA sequences. Clinical applications of MMR deficiency in colorectal adenocarcinoma are as a prognostic marker as well as Predictive marker for adjuvant chemotherapy and immunotherapy. To assess the MMR status of colorectal adenocarcinomas.: This was a retrospective study of 127 colorectal adenocarcinomas cases. All the samples were either biopsies or surgically resected tumor tissues from patients of Carcinoma Colon and rectum. Immunohistochemistry was performed on Roche Ventana Benchmark XT autostainer.: MLH-1, PMS2, MSH2 and MSH6 expression was retained in the tumor cells in 106 cases and it was lost in 21 cases. Among various clinicopathological variables, tumor site and AJCC pStage were found to be significantly associated with dMMR tumors. Patients of colorectal adenocarcinomas were benefited by MMR testing as it influenced the adjuvant treatment in all Stage IIA cases as well as all metastatic cases. Incorporating MMR testing into routine clinical practice can help optimize patient management and treatment strategies in CRC.
{"title":"MMR status of colorectal carcinomas at a tertiary cancer care centre in Central India","authors":"Meena Pangarkar, Satabdi Das, Radhika Pagey, Shweta Deulkar, Shraddha Mahindra, Yogita Devi, Anand Pathak","doi":"10.18231/j.ijpo.2024.031","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.031","url":null,"abstract":"Microsatellite instability (MSI) and mismatch repair (MMR) deficiency are important biomarkers in colorectal cancer (CRC) that have clinical implications for patient management and treatment. MMR deficiency can lead to MSI, which is characterized by alterations in the length of microsatellite DNA sequences. Clinical applications of MMR deficiency in colorectal adenocarcinoma are as a prognostic marker as well as Predictive marker for adjuvant chemotherapy and immunotherapy. To assess the MMR status of colorectal adenocarcinomas.: This was a retrospective study of 127 colorectal adenocarcinomas cases. All the samples were either biopsies or surgically resected tumor tissues from patients of Carcinoma Colon and rectum. Immunohistochemistry was performed on Roche Ventana Benchmark XT autostainer.: MLH-1, PMS2, MSH2 and MSH6 expression was retained in the tumor cells in 106 cases and it was lost in 21 cases. Among various clinicopathological variables, tumor site and AJCC pStage were found to be significantly associated with dMMR tumors. Patients of colorectal adenocarcinomas were benefited by MMR testing as it influenced the adjuvant treatment in all Stage IIA cases as well as all metastatic cases. Incorporating MMR testing into routine clinical practice can help optimize patient management and treatment strategies in CRC.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"116 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.037
Gowthami Nagendran, Bushra Siddiqui, Arshi Khan, Heba Khalid
Primary ovarian squamous cell carcinoma is a rare entity that usually arises from the malignant transformation of a mature cystic teratoma, endometriosis or Brenner’s tumor. The denovo occurrence of primary squamous cell carcinoma of the ovary without prior lesion is a rare entity accounting for less than 1%. However, ovarian squamous cell carcinoma arising from an epidermoid cyst is an infrequent entity and only one case has been reported in literature. The prognosis of such cases is quite poor and there are no definite guidelines for treatment. Here we present a case of a 50-year-old female diagnosed with primary ovarian squamous cell carcinoma arising from an epidermoid cyst of the ovary who was treated with surgery followed by chemotherapy along with the review of literature.
{"title":"Primary ovarian squamous cell carcinoma arising from an epidermoid cyst of Ovary- A rare case report with review of literature","authors":"Gowthami Nagendran, Bushra Siddiqui, Arshi Khan, Heba Khalid","doi":"10.18231/j.ijpo.2024.037","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.037","url":null,"abstract":"Primary ovarian squamous cell carcinoma is a rare entity that usually arises from the malignant transformation of a mature cystic teratoma, endometriosis or Brenner’s tumor. The denovo occurrence of primary squamous cell carcinoma of the ovary without prior lesion is a rare entity accounting for less than 1%. However, ovarian squamous cell carcinoma arising from an epidermoid cyst is an infrequent entity and only one case has been reported in literature. The prognosis of such cases is quite poor and there are no definite guidelines for treatment. Here we present a case of a 50-year-old female diagnosed with primary ovarian squamous cell carcinoma arising from an epidermoid cyst of the ovary who was treated with surgery followed by chemotherapy along with the review of literature.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"30 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.026
Preeti Tripathi, Rama Hariharan, Umesh Kapoor
Iron deficiency anemia (IDA) is the most common type of anemia globally (IDA), the treatment being iron supplementation. However, in a few individuals, there is absent to suboptimal response to iron supplementation due to iron not being taken up by the body of the individual. This condition is known as iron-refractory IDA (IRIDA). Iron refractory iron deficiency anemia is a rare genetic condition that follows an autosomal recessive inheritance due to a defect in the TMPRSS6 gene encoding Matriptase-2. This protein is a transmembrane serine protease that plays an essential role in down-regulating hepcidin, the key regulator of iron homeostasis. Hallmarks of this disease are microcytic hypochromic anemia, low transferrin saturation, and normal/high serum hepcidin values. The anemia appears in the post-natal period, although in some cases it is only diagnosed in adulthood. The disease is refractory to oral iron treatment but shows a slow response to intravenous iron injections and partial correction of the anemia. This condition is likely being missed or under-diagnosed in our iron deficient endemic setting due to a lack of general awareness amongst physicians in establishing the diagnosis or due to the lack of availability of proper genetic testing.
{"title":"IRIDA- An Indian perspective","authors":"Preeti Tripathi, Rama Hariharan, Umesh Kapoor","doi":"10.18231/j.ijpo.2024.026","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.026","url":null,"abstract":"Iron deficiency anemia (IDA) is the most common type of anemia globally (IDA), the treatment being iron supplementation. However, in a few individuals, there is absent to suboptimal response to iron supplementation due to iron not being taken up by the body of the individual. This condition is known as iron-refractory IDA (IRIDA). Iron refractory iron deficiency anemia is a rare genetic condition that follows an autosomal recessive inheritance due to a defect in the TMPRSS6 gene encoding Matriptase-2. This protein is a transmembrane serine protease that plays an essential role in down-regulating hepcidin, the key regulator of iron homeostasis. Hallmarks of this disease are microcytic hypochromic anemia, low transferrin saturation, and normal/high serum hepcidin values. The anemia appears in the post-natal period, although in some cases it is only diagnosed in adulthood. The disease is refractory to oral iron treatment but shows a slow response to intravenous iron injections and partial correction of the anemia. This condition is likely being missed or under-diagnosed in our iron deficient endemic setting due to a lack of general awareness amongst physicians in establishing the diagnosis or due to the lack of availability of proper genetic testing.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"16 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.029
G. A. Vasugi, Giri Pranav, Karthika Padmavathy, Divya Dhanabal, Arthi Arun
: Thyroid carcinomas were significantly on the rise all over the world, with 5.86 lakh new cases and 43,664 deaths reported in 2020. In this study, we focused on a detailed analysis pertaining to the incidence and demographic profile of all histological types of thyroid malignancies. : All cases of thyroid carcinomas reported in the department of Pathology at a tertiary care center in South India from January 2016-December 2020 were included in this study. The demographic profile and patient details were obtained from the medical records section. Pathology reports of the included cases were retrieved, and associated factors were analysed. : Out of the 98 cases included in the study, 16 cases (16.3%) were below 30 years of age, 44 cases (44.9%) were 30-50 years of age and 38 cases (38.8%) were above 50 years of age. The mean age was 45.78. Female preponderance was noted, with 66 cases (67.3%) being females and 32 cases (32.65%) were males. The histopathology results revealed 90 cases (91.8%) to be papillary carcinoma, 1 case (1.02%) of medullary carcinoma, 1 case (1.02%) of Insular carcinoma, 5 cases (5.102%) of follicular carcinoma and 1 case (1.02%) of anaplastic carcinoma. Most of the cases were classified as T1 tumours (45.91%) under the TNM classification. 24 cases (24.49%) were graded as N1 (Metastasis to regional nodes). 3 cases (3.06%) exhibited distant metastasis. Majority of the cases (71.42%) were samples from a total thyroidectomy procedure. : In our demographic study, we have noted that thyroid carcinomas have a peak incidence in the fourth decade of life with a female preponderance. Majority of the cases were noted to be papillary carcinomas in histological type. Understanding the histopathology and TNM staging of thyroid carcinomas is crucial for the selection of appropriate treatment modalities, predicting patient prognosis and clinical outcomes.
{"title":"Demographic profile of thyroid malignancies in a tertiary care centre in South India","authors":"G. A. Vasugi, Giri Pranav, Karthika Padmavathy, Divya Dhanabal, Arthi Arun","doi":"10.18231/j.ijpo.2024.029","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.029","url":null,"abstract":": Thyroid carcinomas were significantly on the rise all over the world, with 5.86 lakh new cases and 43,664 deaths reported in 2020. In this study, we focused on a detailed analysis pertaining to the incidence and demographic profile of all histological types of thyroid malignancies. : All cases of thyroid carcinomas reported in the department of Pathology at a tertiary care center in South India from January 2016-December 2020 were included in this study. The demographic profile and patient details were obtained from the medical records section. Pathology reports of the included cases were retrieved, and associated factors were analysed. : Out of the 98 cases included in the study, 16 cases (16.3%) were below 30 years of age, 44 cases (44.9%) were 30-50 years of age and 38 cases (38.8%) were above 50 years of age. The mean age was 45.78. Female preponderance was noted, with 66 cases (67.3%) being females and 32 cases (32.65%) were males. The histopathology results revealed 90 cases (91.8%) to be papillary carcinoma, 1 case (1.02%) of medullary carcinoma, 1 case (1.02%) of Insular carcinoma, 5 cases (5.102%) of follicular carcinoma and 1 case (1.02%) of anaplastic carcinoma. Most of the cases were classified as T1 tumours (45.91%) under the TNM classification. 24 cases (24.49%) were graded as N1 (Metastasis to regional nodes). 3 cases (3.06%) exhibited distant metastasis. Majority of the cases (71.42%) were samples from a total thyroidectomy procedure. : In our demographic study, we have noted that thyroid carcinomas have a peak incidence in the fourth decade of life with a female preponderance. Majority of the cases were noted to be papillary carcinomas in histological type. Understanding the histopathology and TNM staging of thyroid carcinomas is crucial for the selection of appropriate treatment modalities, predicting patient prognosis and clinical outcomes.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"31 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.041
Preeti Jhaveri, Shivani Kanjibhai Patel, Minesh B Gandhi, Cherry K Shah
Pineoblastoma is a very rare and aggressive malignant tumor of pineal gland. We report a case of 12-year-old male patient presented to S.V.P. tertiary care hospital with complain of progressive loss of vision in both eyes with nausea and headache. On examination bilateral upward gaze palsy was present. The magnetic resonance imaging report revealed possibility of pineal Germinoma. The patient underwent ventriculoperitoneal shunt insertion surgery for obstructive hydrocephalus and suboccipital craniectomy for tumor resection. The Histopathological examination report stated the tumor as Pineoblastoma, Grade IV. Immunohistochemistry studies were positive for synaptophysin and Integrase interactor-1 (INI-1) markers with high ki-67 labelling index and negative for CD-117 and Glial fibrillary acid protein (GFAP) markers. Microscopic and Immuno histochemisty findings are important to differentiate pineoblastoma from other pineal region tumors.
{"title":"A rare case of pineoblastoma – Case report","authors":"Preeti Jhaveri, Shivani Kanjibhai Patel, Minesh B Gandhi, Cherry K Shah","doi":"10.18231/j.ijpo.2024.041","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.041","url":null,"abstract":"Pineoblastoma is a very rare and aggressive malignant tumor of pineal gland. We report a case of 12-year-old male patient presented to S.V.P. tertiary care hospital with complain of progressive loss of vision in both eyes with nausea and headache. On examination bilateral upward gaze palsy was present. The magnetic resonance imaging report revealed possibility of pineal Germinoma. The patient underwent ventriculoperitoneal shunt insertion surgery for obstructive hydrocephalus and suboccipital craniectomy for tumor resection. The Histopathological examination report stated the tumor as Pineoblastoma, Grade IV. Immunohistochemistry studies were positive for synaptophysin and Integrase interactor-1 (INI-1) markers with high ki-67 labelling index and negative for CD-117 and Glial fibrillary acid protein (GFAP) markers. Microscopic and Immuno histochemisty findings are important to differentiate pineoblastoma from other pineal region tumors.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"32 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.042
Gayatri Ajay Bamaniya, Krishna Kanubhai Patel, Cherry K Shah
Primary leiomyosarcoma of small intestine originating from smooth muscle cell is extremely rare entity. It mimics gastrointestinal stromal tumor (GIST) because of their common morphological appearance. Microscopic and immunochemistry findings are necessary to differentiate Leiomyosarcoma from gastrointestinal tumor (GIST). We report a case of 58-year-old male patient presented to tertiary care hospital with complain of generalized abdominal pain, vomiting, early satiety and constipation. Physical examination revealed no significant findings. Imaging findings showed Ileo-Ileal intussusceptions. Neither CT scan nor MRI reveal any evidence of tumor. The patient underwent exploratory laparotomy which revealed polypoidal mass in ileum. Resection and anastomosis of distal Ileum done & specimen received in histopathology department. On microscopic examination, Diagnosis of GIST & Leiomyosarcoma was considered. Immunohistochemistry was positive for Desmin marker and negative for CD 117, DOG 1, S-100 & ALK marker. The diagnosis of High grade Leiomyosarcoma was confirmed.
{"title":"A primary leiomyosarcoma of small intestine: A rare case report","authors":"Gayatri Ajay Bamaniya, Krishna Kanubhai Patel, Cherry K Shah","doi":"10.18231/j.ijpo.2024.042","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.042","url":null,"abstract":"Primary leiomyosarcoma of small intestine originating from smooth muscle cell is extremely rare entity. It mimics gastrointestinal stromal tumor (GIST) because of their common morphological appearance. Microscopic and immunochemistry findings are necessary to differentiate Leiomyosarcoma from gastrointestinal tumor (GIST). We report a case of 58-year-old male patient presented to tertiary care hospital with complain of generalized abdominal pain, vomiting, early satiety and constipation. Physical examination revealed no significant findings. Imaging findings showed Ileo-Ileal intussusceptions. Neither CT scan nor MRI reveal any evidence of tumor. The patient underwent exploratory laparotomy which revealed polypoidal mass in ileum. Resection and anastomosis of distal Ileum done & specimen received in histopathology department. On microscopic examination, Diagnosis of GIST & Leiomyosarcoma was considered. Immunohistochemistry was positive for Desmin marker and negative for CD 117, DOG 1, S-100 & ALK marker. The diagnosis of High grade Leiomyosarcoma was confirmed.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"40 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.028
Vineet Banga, Aarushi Soota
: Anaemia is a widespread public health problem, more common in developing countries. Red blood cell histogram is a vital part for evaluation and diagnosis of anaemia. Histogram can be a useful modality for arriving at the probable diagnosis of anaemia reporting in short span of time.: To observe various RBC Histogram on haematology Analyser in anaemia and analyse the usefulness of RBC Histogram to correlate with peripheral smear.: A prospective study was done in Department of Pathology of Secondary Care hospital from January 2024 to March 2024 on 300 anaemia patients. RBC Histogram were observed, analysed and correlated with peripheral smear. Out of total 300 patients, Most common anaemia is Microcytic Hypochromic (60%), Normocytic normochromic (21.33%), Dimorphic anaemia (12.33%) and macrocytic anaemia (6%). 95.5% microcytic hypochromic anaemia showed left shifted curve, 84.3% Normocytic normochromic anaemia showed normal curve, 88% macrocytic anaemia showed right shift curve. Considering the speed, reliability and less inter observer variation of the modern haematological analysers RBC histogram are important diagnostic tool for various types of anaemia and provide accurate morphological typing of anaemia in most cases hence presumptive report can be released based on RBC histogram.
{"title":"RBC histogram: Useful diagnostic tool in evaluating anaemia","authors":"Vineet Banga, Aarushi Soota","doi":"10.18231/j.ijpo.2024.028","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.028","url":null,"abstract":": Anaemia is a widespread public health problem, more common in developing countries. Red blood cell histogram is a vital part for evaluation and diagnosis of anaemia. Histogram can be a useful modality for arriving at the probable diagnosis of anaemia reporting in short span of time.: To observe various RBC Histogram on haematology Analyser in anaemia and analyse the usefulness of RBC Histogram to correlate with peripheral smear.: A prospective study was done in Department of Pathology of Secondary Care hospital from January 2024 to March 2024 on 300 anaemia patients. RBC Histogram were observed, analysed and correlated with peripheral smear. Out of total 300 patients, Most common anaemia is Microcytic Hypochromic (60%), Normocytic normochromic (21.33%), Dimorphic anaemia (12.33%) and macrocytic anaemia (6%). 95.5% microcytic hypochromic anaemia showed left shifted curve, 84.3% Normocytic normochromic anaemia showed normal curve, 88% macrocytic anaemia showed right shift curve. Considering the speed, reliability and less inter observer variation of the modern haematological analysers RBC histogram are important diagnostic tool for various types of anaemia and provide accurate morphological typing of anaemia in most cases hence presumptive report can be released based on RBC histogram.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.027
L. Sarkar, S. Jagtap, Shubham S Jagtap, D. Dodia
Myxopapillary ependymoma is a rare spinal cord tumors. The intramedullary myxopapillary ependymomas are. Herewith case of a 41-year-old male complaint of a nonspecific low back pain, progressive inability to bend, right lower limb pain with numbness of six month duration. On clinical evaluation right lower limb weakness was noted while the sensations were normal. There was no any significant past history. MRI lumbo-sacral spine with whole spine screening was performed. It showed lobulated heterogenous intensity enhancing intra medullary mass lesion in thecal sac extending from L4-L5 to S1-S2 level. It measured about 52 x 28 x 21 mm. MRI features suggestive of neoplasm – ependymoma was made. The gross total surgical resection was performed. On histopathological findings reported as myxopapillary ependymoma grade 2. The tumor on immunohistochemistry showed positive for EMA, GFAP. While negative for CMYC. The Ki-67 proliferation index (MIB1) was 3%. On follow up there was no tumor recurrence. Rehabilitation therapy was initiated and follow up is advised.
肌乳头状上皮瘤是一种罕见的脊髓肿瘤。髓内肌乳头状上皮瘤是一种罕见的脊髓肿瘤。本病例是一名 41 岁的男性，主诉非特异性腰背痛、进行性无法弯腰、右下肢疼痛伴麻木，病程 6 个月。临床评估发现，患者右下肢无力，但感觉正常。既往无任何重要病史。患者接受了全脊柱筛查，并接受了骶骨磁共振成像检查。结果显示，髓囊内的分叶状异质强化肿块病变从L4-L5延伸至S1-S2水平。肿块大小约为 52 x 28 x 21 毫米。磁共振成像特征提示为肿瘤--上皮瘤。手术对其进行了全切。组织病理结果报告为肌乳头状上皮瘤 2 级。肿瘤的免疫组化显示 EMA 和 GFAP 阳性，而 CMYC 阴性。CMYC阴性。Ki-67增殖指数（MIB1）为3%。经随访，肿瘤没有复发。已开始康复治疗，建议进行随访。
{"title":"Myxopapillary ependymoma of the spinal cord: A case with literature review","authors":"L. Sarkar, S. Jagtap, Shubham S Jagtap, D. Dodia","doi":"10.18231/j.ijpo.2024.027","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.027","url":null,"abstract":"Myxopapillary ependymoma is a rare spinal cord tumors. The intramedullary myxopapillary ependymomas are. Herewith case of a 41-year-old male complaint of a nonspecific low back pain, progressive inability to bend, right lower limb pain with numbness of six month duration. On clinical evaluation right lower limb weakness was noted while the sensations were normal. There was no any significant past history. MRI lumbo-sacral spine with whole spine screening was performed. It showed lobulated heterogenous intensity enhancing intra medullary mass lesion in thecal sac extending from L4-L5 to S1-S2 level. It measured about 52 x 28 x 21 mm. MRI features suggestive of neoplasm – ependymoma was made. The gross total surgical resection was performed. On histopathological findings reported as myxopapillary ependymoma grade 2. The tumor on immunohistochemistry showed positive for EMA, GFAP. While negative for CMYC. The Ki-67 proliferation index (MIB1) was 3%. On follow up there was no tumor recurrence. Rehabilitation therapy was initiated and follow up is advised.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpo.2024.046
Hinal K Gajjar, Monali Dineshbhai Makasana, Preeti Jhaveri
Kimura’s disease (KD) is a benign rare chronic inflammatory condition. It usually presents as a mass lesion in the subcutaneous tissue of the head and neck region or in the major salivary glands, often associated with regional lymphadenopathy. Kimura’s disease seen in an endemic form in Asia but also in other parts of the world, including the United States and Europe. This condition is characterised by painless nodules beneath skin, elevated levels of eosinophils in the blood as well as in tissue with increased level of IgE. We report a case of Kimura’s disease in 26-year-old man who presented with swelling in postauricular area.
{"title":"A case report on Kimura’s disease","authors":"Hinal K Gajjar, Monali Dineshbhai Makasana, Preeti Jhaveri","doi":"10.18231/j.ijpo.2024.046","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.046","url":null,"abstract":"Kimura’s disease (KD) is a benign rare chronic inflammatory condition. It usually presents as a mass lesion in the subcutaneous tissue of the head and neck region or in the major salivary glands, often associated with regional lymphadenopathy. Kimura’s disease seen in an endemic form in Asia but also in other parts of the world, including the United States and Europe. This condition is characterised by painless nodules beneath skin, elevated levels of eosinophils in the blood as well as in tissue with increased level of IgE. We report a case of Kimura’s disease in 26-year-old man who presented with swelling in postauricular area.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"19 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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