Pub Date : 2023-12-15DOI: 10.18231/j.ijpo.2023.075
Bhanushree C S
{"title":"Serrated lesions of colon","authors":"Bhanushree C S","doi":"10.18231/j.ijpo.2023.075","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.075","url":null,"abstract":"","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"54 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.ijpo.2023.080
V. S. Das, Charumathy Kathireshan, V. P. Bhushan
: Ovarian neoplasms are the fifth leading cause of cancer mortality among females worldwide. It is associated with poor survival due to late clinical presentation with most cases presenting at stage III or stage IV.: The present study was undertaken to assess the histopathological spectrum of ovarian neoplasms according to the World Health Organization classification (2020) and to determine the frequency and age distribution of these neoplasms in a tertiary care hospital. : This observational study was conducted over a period of 3 years (August 2016 to July 2019) in the Department of Pathology, Gandhi Medical College, Telangana, India. All ovarian neoplasm specimens were routinely processed and histopathological examination was done for each specimen.: A total of 115 cases were included in the study out of which 97 (84.34%) cases were benign, 6 (5.22%) cases were borderline and 12 (10.44%) cases were malignant. Surface epithelial tumours were the most common, followed by germ cell tumours and sex cord-stromal tumours. The age group of 31-40 years showed the largest percentage of ovarian neoplasms.: Ovaries are a common site for tumours. Most patients present at late stages due to non-specific symptoms. Ovarian neoplasms are associated with a variety of clinical and morphological features and hence a correct histopathological diagnosis is required to institute appropriate therapy.
{"title":"Histopathological spectrum of ovarian neoplasms - A 3 year hospital based study","authors":"V. S. Das, Charumathy Kathireshan, V. P. Bhushan","doi":"10.18231/j.ijpo.2023.080","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.080","url":null,"abstract":": Ovarian neoplasms are the fifth leading cause of cancer mortality among females worldwide. It is associated with poor survival due to late clinical presentation with most cases presenting at stage III or stage IV.: The present study was undertaken to assess the histopathological spectrum of ovarian neoplasms according to the World Health Organization classification (2020) and to determine the frequency and age distribution of these neoplasms in a tertiary care hospital. : This observational study was conducted over a period of 3 years (August 2016 to July 2019) in the Department of Pathology, Gandhi Medical College, Telangana, India. All ovarian neoplasm specimens were routinely processed and histopathological examination was done for each specimen.: A total of 115 cases were included in the study out of which 97 (84.34%) cases were benign, 6 (5.22%) cases were borderline and 12 (10.44%) cases were malignant. Surface epithelial tumours were the most common, followed by germ cell tumours and sex cord-stromal tumours. The age group of 31-40 years showed the largest percentage of ovarian neoplasms.: Ovaries are a common site for tumours. Most patients present at late stages due to non-specific symptoms. Ovarian neoplasms are associated with a variety of clinical and morphological features and hence a correct histopathological diagnosis is required to institute appropriate therapy.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"4 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139001065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.ijpo.2023.078
Akash Khandvi, Akshar M Chauhan, Neeru D Dave, Darshan D Dave
The pancreas has important endocrine and exocrine function and diseases of it causes significant morbidity and mortality. Diseases of the pancreas thus remain a continuing source of frustration in modern medicine. Clinical parameters have their limitations in diagnosing such lesions. Radiological evaluation also helps in diagnosing these lesions but to a certain extent. A good tumor marker is the answer to these problems. There are two tumor markers CA 242 and CA 19.9 which will not only help in early diagnosis of various pancreatic lesions, but also in differentiating them into neoplastic & non-neoplastic lesions. 100 patients of various pancreatic lesions were evaluated prospectively having USG confirmed pancreatic lesions, unexplained pancreatitis, pancreatic mass or pancreatic cystic lesion or worrisome clinical, imaging (CECT/USG) or laboratory findings.Serum tumor marker CA 242 is more specific (100%) than CA 19.9(75%) and CA 19.9(71.9%) is more sensitive than CA 242(70.1%) in patients of various pancreatic lesions. While combined serum tumor marker CA 19.9 and CA 242 was more sensitive (70.5%) and specific (100%) than CA 19.9 and CA 242 alone. For detection of various pancreatic lesions by serum tumor marker CA 19.9 and CA 242, the sensitivity, specificity and positive predictive value increases if markers are used in combination (serum tumor marker CA 19.9 and CA 242).
胰腺具有重要的内分泌和外分泌功能，胰腺疾病会导致严重的发病率和死亡率。因此，胰腺疾病一直是现代医学的一大难题。临床参数在诊断此类病变时有其局限性。放射学评估在一定程度上也有助于诊断这些病变。一个好的肿瘤标记物可以解决这些问题。CA 242 和 CA 19.9 这两种肿瘤标志物不仅有助于各种胰腺病变的早期诊断，还能将它们区分为肿瘤性和非肿瘤性病变。在各种胰腺病变患者中，血清肿瘤标记物 CA 242 的特异性（100%）高于 CA 19.9（75%），CA 19.9（71.9%）的敏感性高于 CA 242（70.1%）。与单独检测 CA 19.9 和 CA 242 相比，联合检测血清肿瘤标记物 CA 19.9 和 CA 242 的敏感性（70.5%）和特异性（100%）更高。用血清肿瘤标记物 CA 19.9 和 CA 242 检测各种胰腺病变时，如果联合使用标记物（血清肿瘤标记物 CA 19.9 和 CA 242），灵敏度、特异性和阳性预测值都会增加。
{"title":"Comparative role of tumor marker CA 242 and CA 19.9 in various pancreatic lesions","authors":"Akash Khandvi, Akshar M Chauhan, Neeru D Dave, Darshan D Dave","doi":"10.18231/j.ijpo.2023.078","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.078","url":null,"abstract":"The pancreas has important endocrine and exocrine function and diseases of it causes significant morbidity and mortality. Diseases of the pancreas thus remain a continuing source of frustration in modern medicine. Clinical parameters have their limitations in diagnosing such lesions. Radiological evaluation also helps in diagnosing these lesions but to a certain extent. A good tumor marker is the answer to these problems. There are two tumor markers CA 242 and CA 19.9 which will not only help in early diagnosis of various pancreatic lesions, but also in differentiating them into neoplastic & non-neoplastic lesions. 100 patients of various pancreatic lesions were evaluated prospectively having USG confirmed pancreatic lesions, unexplained pancreatitis, pancreatic mass or pancreatic cystic lesion or worrisome clinical, imaging (CECT/USG) or laboratory findings.Serum tumor marker CA 242 is more specific (100%) than CA 19.9(75%) and CA 19.9(71.9%) is more sensitive than CA 242(70.1%) in patients of various pancreatic lesions. While combined serum tumor marker CA 19.9 and CA 242 was more sensitive (70.5%) and specific (100%) than CA 19.9 and CA 242 alone. For detection of various pancreatic lesions by serum tumor marker CA 19.9 and CA 242, the sensitivity, specificity and positive predictive value increases if markers are used in combination (serum tumor marker CA 19.9 and CA 242).","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"297 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.ijpo.2023.082
Deepthi Pidigundla, Bhagyalakshmi Junutula, Sivasankara Naik V
Abnormal uterine bleeding (AUB) is a most common gynecological complaint associated with co morbidities that affects quality of life in women. The Aim of the study was to ananlyze the hisopathological patterns of endometrium in women with AUB and to determine the various histopatterns among different age groups of women presenting with AUB. This is a prospective study conducted at Government medical college, Anantapuramu, from January 2021 to December 2022.Endometrial samples with clinical diagnosis of AUB, in whom Gestational causes were ruled out, were included in this study, Statistical data ananlysis was done using SSPS software. A total of 360 cases were analyzed. The prevalence of AUB most common in perimenopausal age group women. Mennorhagia (79.8%) was the common bleeding pattern. The bleeding pattern was significantly associated with age groups(p=0.00).The functional cause (64.2%) of AUB was more common than Organic cause (35.8%).The association of functional and organic causes with age group was not significant. The most common histological pattern was the normal cyclical pattern showing proliferative phase (54.1%). 94 cases showed hisopathological pattern of Hyperplasias that are more common among perimenopausal and postmenopausal age groups. Five cases of Endometrial carcinoma were seen among postmenopausal age group. Three cases were Stage IA, two cases were Stage IB. Obesity and hypertension were most common comorbid conditions seen in this study. Endometrial biopsy should be considered during the workup of women with a clinical diagnosis of AUB to exclude organic pathology especially early detection of precursor lesion of malignancy among perimenopausal and post-menopausal age groups.
{"title":"Diagnostic value of endometrial samples in women with abnormal uterine bleeding at a teritiary care centre","authors":"Deepthi Pidigundla, Bhagyalakshmi Junutula, Sivasankara Naik V","doi":"10.18231/j.ijpo.2023.082","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.082","url":null,"abstract":"Abnormal uterine bleeding (AUB) is a most common gynecological complaint associated with co morbidities that affects quality of life in women. The Aim of the study was to ananlyze the hisopathological patterns of endometrium in women with AUB and to determine the various histopatterns among different age groups of women presenting with AUB. This is a prospective study conducted at Government medical college, Anantapuramu, from January 2021 to December 2022.Endometrial samples with clinical diagnosis of AUB, in whom Gestational causes were ruled out, were included in this study, Statistical data ananlysis was done using SSPS software. A total of 360 cases were analyzed. The prevalence of AUB most common in perimenopausal age group women. Mennorhagia (79.8%) was the common bleeding pattern. The bleeding pattern was significantly associated with age groups(p=0.00).The functional cause (64.2%) of AUB was more common than Organic cause (35.8%).The association of functional and organic causes with age group was not significant. The most common histological pattern was the normal cyclical pattern showing proliferative phase (54.1%). 94 cases showed hisopathological pattern of Hyperplasias that are more common among perimenopausal and postmenopausal age groups. Five cases of Endometrial carcinoma were seen among postmenopausal age group. Three cases were Stage IA, two cases were Stage IB. Obesity and hypertension were most common comorbid conditions seen in this study. Endometrial biopsy should be considered during the workup of women with a clinical diagnosis of AUB to exclude organic pathology especially early detection of precursor lesion of malignancy among perimenopausal and post-menopausal age groups.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"58 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chondromyxoid fibroma (CMF) is rare benign tumour of bone which are due to incomplete cartilage differentiation and first described by Jaffe and Lichtensein in 1948. CMF’s constitutes for less than 1% of all bone tumors. Histopathology is diagnostic and CMF show lobulated areas of spindle shaped or stellate cells with hypocellular center of chondroid or myxoid material and periphery is hypercellular with abundant fibromyxoid tissue and few multinucleated osteoclasts like giant cell. CMFs are commonly seen in metaphysis of long bones including proximal tibia or distal femur. Short tubular bones of hand and feet are uncommon sites and toes constitutes less than 5% of the tumors. We present a case of chondromyxoid fibroma of distal phalanx of left great toe in 35 years old male patient.
{"title":"A rare case of chondromyxoid fibroma of distal phalanx of great toe","authors":"Sachin Sharma, Jyoti Kashyap, Ankur Sharma, Abhishek Dhiman","doi":"10.18231/j.ijpo.2023.088","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.088","url":null,"abstract":"Chondromyxoid fibroma (CMF) is rare benign tumour of bone which are due to incomplete cartilage differentiation and first described by Jaffe and Lichtensein in 1948. CMF’s constitutes for less than 1% of all bone tumors. Histopathology is diagnostic and CMF show lobulated areas of spindle shaped or stellate cells with hypocellular center of chondroid or myxoid material and periphery is hypercellular with abundant fibromyxoid tissue and few multinucleated osteoclasts like giant cell. CMFs are commonly seen in metaphysis of long bones including proximal tibia or distal femur. Short tubular bones of hand and feet are uncommon sites and toes constitutes less than 5% of the tumors. We present a case of chondromyxoid fibroma of distal phalanx of left great toe in 35 years old male patient.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"83 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epithelial ovarian carcinoma is the most common type of all the ovarian cancers. The patients with advanced stage are initially treated with neo-adjuvant chemotherapy followed by interval debulking surgery. The high mortality rate is mainly due to advanced stage disease at initial presentation. This a retrospective study carried out in department of pathology at Bhagwan Mahaveer cancer hospital, Jaipur. The retrospective cases data was collected and analyzed from patient records on basis of inclusion and exclusion criteria.: Patients of advanced ovarian cancer with fibrosis grade 3, necrosis grade 2, presence of psammoma bodies, presence of collagen deposition, low Ki67 index, positive ER status were associated with longer DFS (p value= 0.014,0.029,0.033,0.028,0.001 and 0.001 respectively) and OS (P value 0.025,0.005,0.002,0.015,0.001 and 0.001 respectively).We propose that the prognostic histopathological parameters analysed in our study in post NACT patients of ovarian carcinoma should be reported in final histopathological report, as these factors can provide an extra tool for clinicians to optimize patient management and care.
{"title":"Histopathological prognostic factors in post NACT ovarian cancers: A retrospective study","authors":"Navjot Kaur, Rajandeep Singh Sethi, Anjali Sharma, Deepshikha Parakh, Annie Baghla","doi":"10.18231/j.ijpo.2023.079","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.079","url":null,"abstract":"Epithelial ovarian carcinoma is the most common type of all the ovarian cancers. The patients with advanced stage are initially treated with neo-adjuvant chemotherapy followed by interval debulking surgery. The high mortality rate is mainly due to advanced stage disease at initial presentation. This a retrospective study carried out in department of pathology at Bhagwan Mahaveer cancer hospital, Jaipur. The retrospective cases data was collected and analyzed from patient records on basis of inclusion and exclusion criteria.: Patients of advanced ovarian cancer with fibrosis grade 3, necrosis grade 2, presence of psammoma bodies, presence of collagen deposition, low Ki67 index, positive ER status were associated with longer DFS (p value= 0.014,0.029,0.033,0.028,0.001 and 0.001 respectively) and OS (P value 0.025,0.005,0.002,0.015,0.001 and 0.001 respectively).We propose that the prognostic histopathological parameters analysed in our study in post NACT patients of ovarian carcinoma should be reported in final histopathological report, as these factors can provide an extra tool for clinicians to optimize patient management and care.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.ijpo.2023.083
Mbessoh Kengne Ulrich Igor, Salif Balde, Mamadou Ndiaye, Ndiaye Mamadou, Ka Sidy, Dem Ahmadou
Core needle biopsy provides information not only on the histological diagnosis but also about tumor grade and different prognosis factors for breast cancer. This study was designed to determine the accuracy of percutaneous core needle biopsy (CNB) through comparative analysis of histological diagnosis and SBR tumor grade of invasive breast cancer between CNB and surgical excision specimen (SES). This was a retrospective cross-sectional study from January 2023 to July 2023. All patients with invasive breast cancer diagnosed by CNB and confirmed by surgical excision specimen (SES) examination were included in the study. Patients who received neoadjuvant chemotherapy were excluded. One twenty-three patients were assessed. All patients were female. The median age was 45 years (37 – 54). Invasive ductal carcinoma (IDC) was the major histological type of breast cancer (95.1%) followed by invasive lobular carcinoma (ILC) (4.9%). SBR grade 2 tumors accounted for 78.1% of cases. The majority of patients presented with locally advanced stage breast cancer (65.9%) or a metastatic disease (31.7%). Concordance for histological type was substantial (k= 0.79; p<0,001) whereas it was moderate (k= 0.45; p<0,001) for Scarf-Bloom-Richardson grade. Histological type on CNB correlates almost perfectly with that of the surgical excisional specimen in case of breast cancer. Nevertheless, the agreement of tumor grade between CNB and SES remains moderate, with a significant underestimation and overestimation rates.
{"title":"The accuracy of core needle biopsy in determining histological type and Scarf-Bloom-Richardson grade in invasive breast cancer","authors":"Mbessoh Kengne Ulrich Igor, Salif Balde, Mamadou Ndiaye, Ndiaye Mamadou, Ka Sidy, Dem Ahmadou","doi":"10.18231/j.ijpo.2023.083","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.083","url":null,"abstract":"Core needle biopsy provides information not only on the histological diagnosis but also about tumor grade and different prognosis factors for breast cancer. This study was designed to determine the accuracy of percutaneous core needle biopsy (CNB) through comparative analysis of histological diagnosis and SBR tumor grade of invasive breast cancer between CNB and surgical excision specimen (SES). This was a retrospective cross-sectional study from January 2023 to July 2023. All patients with invasive breast cancer diagnosed by CNB and confirmed by surgical excision specimen (SES) examination were included in the study. Patients who received neoadjuvant chemotherapy were excluded. One twenty-three patients were assessed. All patients were female. The median age was 45 years (37 – 54). Invasive ductal carcinoma (IDC) was the major histological type of breast cancer (95.1%) followed by invasive lobular carcinoma (ILC) (4.9%). SBR grade 2 tumors accounted for 78.1% of cases. The majority of patients presented with locally advanced stage breast cancer (65.9%) or a metastatic disease (31.7%). Concordance for histological type was substantial (k= 0.79; p<0,001) whereas it was moderate (k= 0.45; p<0,001) for Scarf-Bloom-Richardson grade. Histological type on CNB correlates almost perfectly with that of the surgical excisional specimen in case of breast cancer. Nevertheless, the agreement of tumor grade between CNB and SES remains moderate, with a significant underestimation and overestimation rates.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"115 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colorectal cancer (CRC) is the third most cancer which is prevalent globally. It is the second most leading cause of mortality worldwide. In Asia Colorectal cancer is most abundant type of cancer. Causative factors involved are genetic pattern, western lifestyle, alcohol, smoking, etc. The commonest therapy for colorectal cancer is the combination therapy of 5-fluorouracil with Leucovorin which is either co-administered with alkylating agent Oxaliplatin or with a topoisomerase inhibitor Irinotecan. There is still a need of therapeutic agent that increases the survival rate in colorectal cancer patients. Probiotics are well known to increase the proliferation of beneficial bacteria and recently they are widely researched for regression of carcinogenesis. a commonly used probiotic, is observed to increase the expression of apoptotic ligand by modulating TNF action. has also shown to represses cyclin D1 and inhibit the Wnt/β-catenin signaling thereby, not only prevent the proliferation of cancerous cells but also ensure the apoptosis of CRC cells. Calcium is a vital element in many biological pathways including cancer signaling pathway. A wide variety of research reflects the role of calcium in suppression of cancerous cells. Recently calcium has shown its role in inhibiting Wnt/-catenin signaling canonical pathway in colorectal cancer cells. The review focuses on the role of calcium and probiotic as a natural therapeutic option in the treatment of CRC.
{"title":"Role of Lactobacillus and calcium in colorectal cancer","authors":"Hemant Devidas Une, Mrudula Yogesh Kumavat, Amar Bhagwan Shirsat","doi":"10.18231/j.ijpo.2023.051","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.051","url":null,"abstract":"Colorectal cancer (CRC) is the third most cancer which is prevalent globally. It is the second most leading cause of mortality worldwide. In Asia Colorectal cancer is most abundant type of cancer. Causative factors involved are genetic pattern, western lifestyle, alcohol, smoking, etc. The commonest therapy for colorectal cancer is the combination therapy of 5-fluorouracil with Leucovorin which is either co-administered with alkylating agent Oxaliplatin or with a topoisomerase inhibitor Irinotecan. There is still a need of therapeutic agent that increases the survival rate in colorectal cancer patients. Probiotics are well known to increase the proliferation of beneficial bacteria and recently they are widely researched for regression of carcinogenesis. a commonly used probiotic, is observed to increase the expression of apoptotic ligand by modulating TNF action. has also shown to represses cyclin D1 and inhibit the Wnt/β-catenin signaling thereby, not only prevent the proliferation of cancerous cells but also ensure the apoptosis of CRC cells. Calcium is a vital element in many biological pathways including cancer signaling pathway. A wide variety of research reflects the role of calcium in suppression of cancerous cells. Recently calcium has shown its role in inhibiting Wnt/-catenin signaling canonical pathway in colorectal cancer cells. The review focuses on the role of calcium and probiotic as a natural therapeutic option in the treatment of CRC.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135486097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-15DOI: 10.18231/j.ijpo.2023.064
None Vishnusri R, None Luck C P, None Sangeetha B S, Sarah Kuruvilla
Mammary fibroepithelial lesions encompass a wide spectrum of tumours ranging from an indolent fibroadenoma to potentially fatal malignant phyllodes tumour. Here, we report a case of 22 -year -old unmarried girl with bilateral breast lump for one month who underwent wide local excision which on histopathological examination revealed borderline phyllodes tumour and tubular adenoma in a background of fibrocystic disease with adenosis, marked epithelial hyperplasia, fibro adenomatoid change and apocrine metaplasia a rare occurrence which can be confused with benign and malignant lesions of the breast.
{"title":"Synchronous presentation of borderline phyllodes tumour and tubular adenoma in a background of fibrocystic disease - A case report","authors":"None Vishnusri R, None Luck C P, None Sangeetha B S, Sarah Kuruvilla","doi":"10.18231/j.ijpo.2023.064","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.064","url":null,"abstract":"Mammary fibroepithelial lesions encompass a wide spectrum of tumours ranging from an indolent fibroadenoma to potentially fatal malignant phyllodes tumour. Here, we report a case of 22 -year -old unmarried girl with bilateral breast lump for one month who underwent wide local excision which on histopathological examination revealed borderline phyllodes tumour and tubular adenoma in a background of fibrocystic disease with adenosis, marked epithelial hyperplasia, fibro adenomatoid change and apocrine metaplasia a rare occurrence which can be confused with benign and malignant lesions of the breast.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135486209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-15DOI: 10.18231/j.ijpo.2023.054
None Neetha Y, Pranjal Nath, Shashikala P Krishnamurthy, Kavita G Umapathy
Voluntary blood donors are the mainstay of any blood donation camp, whether in a hospital or in a blood bank. Selection of such donors becomes an important element in any blood donation program. However, the spread of COVID-19 worldwide had a crippling impact on blood donations/ blood safety and had posed a huge challenge. Hence, an insight into conduction of a blood donation camp during the pandemic and analysis of reasons for donor deferral becomes highly important. This is an observational study about a voluntary blood donation camp held for general public during the second wave of COVID-19 in a school at Kottur, Karnataka. Donor details were taken with the help of questionnaires. Procedures and safety protocols put in place during donation was noted and reasons for deferral obtained from donor questionnaires and by examination of donors was analyzed. The blood donation camp was conducted with proper COVID-19 guidelines. A total of 105 individuals came for donation of which 37 were deferred. 6 deferrals were due to COVID-related cause, 31 deferrals were non-COVID related and overall the most common cause of deferral was hypertension. With the help of proper safety measures, blood donation camps can be successfully conducted during pandemic like COVID-19. And the crisis for blood and its products can be met by adopting appropriate guidelines.
{"title":"Voluntary blood donation camp- A challenge during COVID-19 pandemic","authors":"None Neetha Y, Pranjal Nath, Shashikala P Krishnamurthy, Kavita G Umapathy","doi":"10.18231/j.ijpo.2023.054","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.054","url":null,"abstract":"Voluntary blood donors are the mainstay of any blood donation camp, whether in a hospital or in a blood bank. Selection of such donors becomes an important element in any blood donation program. However, the spread of COVID-19 worldwide had a crippling impact on blood donations/ blood safety and had posed a huge challenge. Hence, an insight into conduction of a blood donation camp during the pandemic and analysis of reasons for donor deferral becomes highly important. This is an observational study about a voluntary blood donation camp held for general public during the second wave of COVID-19 in a school at Kottur, Karnataka. Donor details were taken with the help of questionnaires. Procedures and safety protocols put in place during donation was noted and reasons for deferral obtained from donor questionnaires and by examination of donors was analyzed. The blood donation camp was conducted with proper COVID-19 guidelines. A total of 105 individuals came for donation of which 37 were deferred. 6 deferrals were due to COVID-related cause, 31 deferrals were non-COVID related and overall the most common cause of deferral was hypertension. With the help of proper safety measures, blood donation camps can be successfully conducted during pandemic like COVID-19. And the crisis for blood and its products can be met by adopting appropriate guidelines.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135485968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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