Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.012
Raghav Kapoor, Anila Sharma, S. Pasricha, M. Kamboj, Anurag Mehta
The term “Perivascular epithelioid cells” was described as early as 1992. WHO has defined PEComas as mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These tumors have a varied morphology including sheets and nested pattern comprising of epithelioid to spindle tumor cells with increased vasculature often in a sinusoidal pattern. PEComas show immunoreactivity for melanocytic and smooth muscle markers, however small number cases show lack of muscle marker expression along with strong TFE3 nuclear positivity. Here we describe a PEComa of soft tissue of leg, TFE3 rearranged.
{"title":"Beyond the ordinary: A rare glimpse of PEComa TFE3 rearranged in soft tissue","authors":"Raghav Kapoor, Anila Sharma, S. Pasricha, M. Kamboj, Anurag Mehta","doi":"10.18231/j.ijpo.2024.012","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.012","url":null,"abstract":"The term “Perivascular epithelioid cells” was described as early as 1992. WHO has defined PEComas as mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These tumors have a varied morphology including sheets and nested pattern comprising of epithelioid to spindle tumor cells with increased vasculature often in a sinusoidal pattern. PEComas show immunoreactivity for melanocytic and smooth muscle markers, however small number cases show lack of muscle marker expression along with strong TFE3 nuclear positivity. Here we describe a PEComa of soft tissue of leg, TFE3 rearranged.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"55 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.021
Thanka Johnson, Abhishri Lakshmi K
Ovarian lesions composed of spindle cells comprise a heterogeneous group; most are neoplastic, but several non-neoplastic lesions may be composed of spindle cells, including massive edema and fibromatosis and ovarian fibroma. Herein we discuss both these non- neoplastic entities as a differential diagnosis for our case of benign spindle cell lesion of ovary.57-year-old post-menopausal female presented with abdominal pain, vomiting, constipation. Computed tomography showed, features of ovarian torsion. Staging laparotomy was done and a specimen of hysterectomy with bilateral salpingoophorectomy, was sent for histopathological examination. Sections from right ovary showed proliferation of spindle cells resembling stromal fibroblasts with large areas of edema and haemorrhage. Masson's trichrome show increased collagen deposition. The tube also shows changes secondary to torsion in the wall. Based on the above features, we made a diagnosis of benign spindle cell lesion of ovary with the differential diagnosis including massive edema and fibromatosis and fibroma of ovary. IHC for Inhibin was ordered which came negative. This confirmed the diagnosis of massive edema and fibromatosis.
{"title":"Massive edema and fibromatosis of ovary: A rare case report","authors":"Thanka Johnson, Abhishri Lakshmi K","doi":"10.18231/j.ijpo.2024.021","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.021","url":null,"abstract":"Ovarian lesions composed of spindle cells comprise a heterogeneous group; most are neoplastic, but several non-neoplastic lesions may be composed of spindle cells, including massive edema and fibromatosis and ovarian fibroma. Herein we discuss both these non- neoplastic entities as a differential diagnosis for our case of benign spindle cell lesion of ovary.57-year-old post-menopausal female presented with abdominal pain, vomiting, constipation. Computed tomography showed, features of ovarian torsion. Staging laparotomy was done and a specimen of hysterectomy with bilateral salpingoophorectomy, was sent for histopathological examination. Sections from right ovary showed proliferation of spindle cells resembling stromal fibroblasts with large areas of edema and haemorrhage. Masson's trichrome show increased collagen deposition. The tube also shows changes secondary to torsion in the wall. Based on the above features, we made a diagnosis of benign spindle cell lesion of ovary with the differential diagnosis including massive edema and fibromatosis and fibroma of ovary. IHC for Inhibin was ordered which came negative. This confirmed the diagnosis of massive edema and fibromatosis.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.017
Swati Priya, S. Mahto, M. K. Paswan, Saurav Banerjee, Arvind Kumar
Uterine sarcomas account for approximately 1% of all gynecologic neoplasm and 3–7% of all uterine cancers. Approximately 1 in every 800 women believed to have a leiomyoma actually has a sarcoma. Here we discuss a case of occult leiomyosarcoma in a hysterectomy specimen suspected to be uterine fibroid preoperatively along with spectrum of diagnoses of uterine mesenchymal tumours and the differentiating parameters. This is a descriptive study. A 48-year-old female with heavy menstrual bleeding since 4-5 years, on USG showed an enlarged uterus containing a fibroid with degenerative changes. Grossly, fibroid is seen (11cm x 8.6cm) greyish white, fleshy, involving more than half of the myometrium. Microscopically, fibroid mass showed highly pleomorphic, hyperchromatic tumour cells with dispersed chromatin and indistinct cytoplasm, arranged in intersecting fascicles. Large areas of coagulative tumour cell necrosis seen, mitotic figures > 10 per 10 HPF, suggesting leiomysarcoma of uterus. Leiomyosarcomas are diagnosed when a triad of histopathological features is seen - significant atypia, increased mitotic activity and coagulative tumour cell necrosis. These are important in differentiating between variants of leiomyoma, STUMP and leiomyosarcoma. Sometimes a benign fibroid-like mass can incidentally be diagnosed as leiomyosarcoma microscopically. It’s essential to avertmorcellation in routine gynecological practice especially in perimenopausal women with a large fibroid to avoid intra-abdominal dissemination. Precise pre-operative radiological workup by MRI or expert-guided sonogram is also suggested but given the complexities involved, role of histopathology to diagnose leiomyosarcoma is invaluable.
{"title":"An occult leiomyosarcoma in a hysterectomy specimen presumed to be uterine fibroid preoperatively: A case report","authors":"Swati Priya, S. Mahto, M. K. Paswan, Saurav Banerjee, Arvind Kumar","doi":"10.18231/j.ijpo.2024.017","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.017","url":null,"abstract":"Uterine sarcomas account for approximately 1% of all gynecologic neoplasm and 3–7% of all uterine cancers. Approximately 1 in every 800 women believed to have a leiomyoma actually has a sarcoma. Here we discuss a case of occult leiomyosarcoma in a hysterectomy specimen suspected to be uterine fibroid preoperatively along with spectrum of diagnoses of uterine mesenchymal tumours and the differentiating parameters. This is a descriptive study. A 48-year-old female with heavy menstrual bleeding since 4-5 years, on USG showed an enlarged uterus containing a fibroid with degenerative changes. Grossly, fibroid is seen (11cm x 8.6cm) greyish white, fleshy, involving more than half of the myometrium. Microscopically, fibroid mass showed highly pleomorphic, hyperchromatic tumour cells with dispersed chromatin and indistinct cytoplasm, arranged in intersecting fascicles. Large areas of coagulative tumour cell necrosis seen, mitotic figures > 10 per 10 HPF, suggesting leiomysarcoma of uterus. Leiomyosarcomas are diagnosed when a triad of histopathological features is seen - significant atypia, increased mitotic activity and coagulative tumour cell necrosis. These are important in differentiating between variants of leiomyoma, STUMP and leiomyosarcoma. Sometimes a benign fibroid-like mass can incidentally be diagnosed as leiomyosarcoma microscopically. It’s essential to avertmorcellation in routine gynecological practice especially in perimenopausal women with a large fibroid to avoid intra-abdominal dissemination. Precise pre-operative radiological workup by MRI or expert-guided sonogram is also suggested but given the complexities involved, role of histopathology to diagnose leiomyosarcoma is invaluable.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"11 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.016
Disha Bipinbhai Patel, Shilpa Gandhi, Gauravi A. Dhruva
Mast cell leukemia is a rare and aggressive clonal disorder of mast cells & their precursor cells. Systemic mastocytosis clinical course ranging from cutaneous mastocytosis, indolent disease, mast leukaemia and multisystem involvement. 14 Y/M presented with skin coloured plaque present over whole body with itching. On histopathological evaluation of skin lesion cutaneous mastocytosis was diagnosed. Further evaluation for systemic involvement by bone marrow aspiration was carried out, which shows hypercellular marrow for age, erythropoiesis and megakaryopoiesis within normal limits. The differential count revealed 70% of all nucleated cells were mast cells, with many large aggregates of >15% cells and 20% atypical mast cells seen as suggestive of MAST CELL LEUKEMIA (Aleukemic leukemia). S.trptase level >200ng/ml.: The presence of the major criteria-bone marrow at least 20% atypical immature mast cell with least ≥15 multifocal dense Mast cells in bone marrow or extracutaneous organ, in addition to at least one minor criterion: 1) presence of atypical morphology in more than 25% Bone marrow or extracellular mast cells 2) Serum tryptase>20ng/ml. 3) Bone marrow, blood or extracutaneous organs: (a) CD2 and/or CD25 positive (b) Detection of KIT mutation at codon 816.: Considering characteristic bone marrow feature, and with biochemical and radiological investigation mast cell leukemia was diagnosed which helping clinicians to plan further management.
{"title":"Mast cell leukemia- A rare case reported","authors":"Disha Bipinbhai Patel, Shilpa Gandhi, Gauravi A. Dhruva","doi":"10.18231/j.ijpo.2024.016","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.016","url":null,"abstract":"Mast cell leukemia is a rare and aggressive clonal disorder of mast cells & their precursor cells. Systemic mastocytosis clinical course ranging from cutaneous mastocytosis, indolent disease, mast leukaemia and multisystem involvement. 14 Y/M presented with skin coloured plaque present over whole body with itching. On histopathological evaluation of skin lesion cutaneous mastocytosis was diagnosed. Further evaluation for systemic involvement by bone marrow aspiration was carried out, which shows hypercellular marrow for age, erythropoiesis and megakaryopoiesis within normal limits. The differential count revealed 70% of all nucleated cells were mast cells, with many large aggregates of >15% cells and 20% atypical mast cells seen as suggestive of MAST CELL LEUKEMIA (Aleukemic leukemia). S.trptase level >200ng/ml.: The presence of the major criteria-bone marrow at least 20% atypical immature mast cell with least ≥15 multifocal dense Mast cells in bone marrow or extracutaneous organ, in addition to at least one minor criterion: 1) presence of atypical morphology in more than 25% Bone marrow or extracellular mast cells 2) Serum tryptase>20ng/ml. 3) Bone marrow, blood or extracutaneous organs: (a) CD2 and/or CD25 positive (b) Detection of KIT mutation at codon 816.: Considering characteristic bone marrow feature, and with biochemical and radiological investigation mast cell leukemia was diagnosed which helping clinicians to plan further management. ","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.002
Agam Hans, Abhishek Yadav, Parneet Kaur, Archana Kumari
: Urinary tract infection is a global health problem affecting all age groups. is the most common cause of UTI followed by , staphylococcus haemolyticus and enterococci etc. The gold standard for detecting an UTI is the presence of pathogen in urine along with clinical symptoms and pyuria. Nitrite (NIT) and leukocyte esterase (LE) tests are two important dip stick tests used for screening UTI. A total of 202 patients who presented with clinical symptoms of UTI from January 2023 to December 2023 were evaluated for urine routine and culture examination. LE and NIT dipstick tests were evaluated and change of colour was considered positive. Microscopic examination of urine was performed manually and urine culture with count of > 10 CFU/ml was considered positive. Statistical data was analysed using IBM SPSS v 29.0.2.0 (20) and Microsoft Excel. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated for both tests.: LE had a sensitivity of 47.22% whereas NIT was much less sensitive (15.27%). Specificity of NIT (99.23%) was higher in comparison to LE (81.53%). NIT had overall better PPV and NPV (91.66%, and 67.89%) as compared to LE (58.62% and 73.61%). The accuracy of LE and NIT were 69.3% and 69.8% respectively. A positive correlation was also seen with increasing WBC count and positive urine culture.: Urine culture along with clinical and routine analysis is necessary for definitive diagnosis of UTI but importance of dipstick chemical examination should not be underestimated. LE and NIT have an additional benefit of quick results in comparison to culture which takes at least 24 hours.
{"title":"Evaluation of Leukocyte esterase and Nitrite dipstick tests with routine urine microscopic analysis in detecting urinary tract infections","authors":"Agam Hans, Abhishek Yadav, Parneet Kaur, Archana Kumari","doi":"10.18231/j.ijpo.2024.002","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.002","url":null,"abstract":": Urinary tract infection is a global health problem affecting all age groups. is the most common cause of UTI followed by , staphylococcus haemolyticus and enterococci etc. The gold standard for detecting an UTI is the presence of pathogen in urine along with clinical symptoms and pyuria. Nitrite (NIT) and leukocyte esterase (LE) tests are two important dip stick tests used for screening UTI. A total of 202 patients who presented with clinical symptoms of UTI from January 2023 to December 2023 were evaluated for urine routine and culture examination. LE and NIT dipstick tests were evaluated and change of colour was considered positive. Microscopic examination of urine was performed manually and urine culture with count of > 10 CFU/ml was considered positive. Statistical data was analysed using IBM SPSS v 29.0.2.0 (20) and Microsoft Excel. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated for both tests.: LE had a sensitivity of 47.22% whereas NIT was much less sensitive (15.27%). Specificity of NIT (99.23%) was higher in comparison to LE (81.53%). NIT had overall better PPV and NPV (91.66%, and 67.89%) as compared to LE (58.62% and 73.61%). The accuracy of LE and NIT were 69.3% and 69.8% respectively. A positive correlation was also seen with increasing WBC count and positive urine culture.: Urine culture along with clinical and routine analysis is necessary for definitive diagnosis of UTI but importance of dipstick chemical examination should not be underestimated. LE and NIT have an additional benefit of quick results in comparison to culture which takes at least 24 hours.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"27 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.004
Madhuri Roy, D. Wakkar
The detection of numerous bacterial, fungal, or viral illnesses as well as malignancies is aided by the cytologic study of bodily cavity fluids. The focus of this study is on the type of malignant cells, their distribution and preservation of morphology, cell yield, and comparing the outcomes for positive cases.: To assess the utility, sensitivity and compare the results obtained by cytocentrifuge (Pr0Cyt.LED4) with those of conventional centrifuge in cytodiagnosis in Tertiary Care Hospital. A prospective investigation was carried out using ascitic, pleural, cerebrospinal, and other bodily cavity fluid samples that were split equally and centrifuged simultaneously at predetermined parameters in an ordinary centrifuge and a cytocentrifuge.For cytodiagnosis, 100 samples were examined. With a p-value less than 0.05, the results demonstrated a statistically significant difference between the two approaches. According to this comparison study, the cytocentrifuge preparation outperforms the ordinary centrifuge in terms of cell yield, well-preserved cell morphology, and ability to pick up malignant cells, hence enhancing its sensitivity and improving its diagnostic use.
{"title":"Comparative study of body fluid cytology using cytocentrifuge and ordinary centrifuge","authors":"Madhuri Roy, D. Wakkar","doi":"10.18231/j.ijpo.2024.004","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.004","url":null,"abstract":"The detection of numerous bacterial, fungal, or viral illnesses as well as malignancies is aided by the cytologic study of bodily cavity fluids. The focus of this study is on the type of malignant cells, their distribution and preservation of morphology, cell yield, and comparing the outcomes for positive cases.: To assess the utility, sensitivity and compare the results obtained by cytocentrifuge (Pr0Cyt.LED4) with those of conventional centrifuge in cytodiagnosis in Tertiary Care Hospital. A prospective investigation was carried out using ascitic, pleural, cerebrospinal, and other bodily cavity fluid samples that were split equally and centrifuged simultaneously at predetermined parameters in an ordinary centrifuge and a cytocentrifuge.For cytodiagnosis, 100 samples were examined. With a p-value less than 0.05, the results demonstrated a statistically significant difference between the two approaches. According to this comparison study, the cytocentrifuge preparation outperforms the ordinary centrifuge in terms of cell yield, well-preserved cell morphology, and ability to pick up malignant cells, hence enhancing its sensitivity and improving its diagnostic use.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"53 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.006
Resha Menon, P. Mahadevan, Merin Jaison
: Gastrointestinal infections, caused due to various viruses, bacteria, fungi, and parasites, are a major global health concern, causing significant morbidity and mortality.: The present study was undertaken to study the histopathological spectrum of infectious diseases of the gastrointestinal tract detected from endoscopic mucosal biopsies at our tertiary care hospital, as well as review the available, relevant clinical details. : This retrospective study included biopsies over a period of 1 year (January 2022 to December 2022) in the Department of Pathology, VPS Lakeshore Hospital, Ernakulam, Kerala, India.: A total of 90 cases of infections of the GIT were included in the study, out of which 76 cases were bacterial, 10 cases were viral and 4 were due to other parasites. : While dealing with infections of the GIT, a thorough knowledge of the microscopic findings and supportive ancillary tests, alongwith clinical findings, aid in confirming the diagnosis and providing options for appropriate patient management.
{"title":"Histopathological spectrum of infectious diseases in endoscopic mucosal biopsies of the gastrointestinal tract: A one-year study at a tertiary care hospital in Kerala","authors":"Resha Menon, P. Mahadevan, Merin Jaison","doi":"10.18231/j.ijpo.2024.006","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.006","url":null,"abstract":": Gastrointestinal infections, caused due to various viruses, bacteria, fungi, and parasites, are a major global health concern, causing significant morbidity and mortality.: The present study was undertaken to study the histopathological spectrum of infectious diseases of the gastrointestinal tract detected from endoscopic mucosal biopsies at our tertiary care hospital, as well as review the available, relevant clinical details. : This retrospective study included biopsies over a period of 1 year (January 2022 to December 2022) in the Department of Pathology, VPS Lakeshore Hospital, Ernakulam, Kerala, India.: A total of 90 cases of infections of the GIT were included in the study, out of which 76 cases were bacterial, 10 cases were viral and 4 were due to other parasites. : While dealing with infections of the GIT, a thorough knowledge of the microscopic findings and supportive ancillary tests, alongwith clinical findings, aid in confirming the diagnosis and providing options for appropriate patient management. ","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"13 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.019
A. Singhai, Akanksha Sharma, Diparati Mondal
Primitive neuroectodermal tumors (PNETs) are uncommon tumors that primarily affect young males. They are rarely seen in the prostate and occurence in an old age group is uncommon. We present a case of a 64-year-old male who presented with complaints of difficulty in passing urine for 1-year duration and on contrast-enhanced computed tomography showed an enlarged mass in the prostate with hypoattenuating areas. Serum prostatic specific antigen was mildly raised. Transurethral resection of prostate was done and histology showed clusters of round cells that expressed CD99. The patient underwent radical surgery for tumor resection. PNETs are tumors of soft tissue origin and generally affect the young age group. This case of PNET in the prostate is unusual for its site and age of presentation. In conclusion, while making a diverse diagnostic evaluation of aggressive prostate cancers, PNET should be taken into account.
{"title":"Primitive neuroectodermal tumor of the prostate in a 64 years old man: An unusually late presentation","authors":"A. Singhai, Akanksha Sharma, Diparati Mondal","doi":"10.18231/j.ijpo.2024.019","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.019","url":null,"abstract":"Primitive neuroectodermal tumors (PNETs) are uncommon tumors that primarily affect young males. They are rarely seen in the prostate and occurence in an old age group is uncommon. We present a case of a 64-year-old male who presented with complaints of difficulty in passing urine for 1-year duration and on contrast-enhanced computed tomography showed an enlarged mass in the prostate with hypoattenuating areas. Serum prostatic specific antigen was mildly raised. Transurethral resection of prostate was done and histology showed clusters of round cells that expressed CD99. The patient underwent radical surgery for tumor resection. PNETs are tumors of soft tissue origin and generally affect the young age group. This case of PNET in the prostate is unusual for its site and age of presentation. In conclusion, while making a diverse diagnostic evaluation of aggressive prostate cancers, PNET should be taken into account.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"39 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ovarian lymphangioma are unusual benign tumours characterized by proliferation of lymphatic channels. The exact etiology and the true occurrence is not well understood. We here in discuss a case of ovarian lymphangioma in 45 yr old female who presented with chief complains of abdominal pain. USG revealed features suggestive of right complex ovarian cyst, that was then excised and send to pathology department for histological analysis. Histopathological examination revealed an ovarian lymphangioma which was further confirmed by IHC marker CD31 that highlighted the endothelial nature of lymphatic channels. Patient was disease free 6 months post surgery and is on regular follow up till date.
{"title":"Lymphangioma of ovary: A case report","authors":"Shushruta Mohanty, Lipika Behera, Ajit Surya Mohapatro, Abhisek Dalai","doi":"10.18231/j.ijpo.2024.013","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.013","url":null,"abstract":"Ovarian lymphangioma are unusual benign tumours characterized by proliferation of lymphatic channels. The exact etiology and the true occurrence is not well understood. We here in discuss a case of ovarian lymphangioma in 45 yr old female who presented with chief complains of abdominal pain. USG revealed features suggestive of right complex ovarian cyst, that was then excised and send to pathology department for histological analysis. Histopathological examination revealed an ovarian lymphangioma which was further confirmed by IHC marker CD31 that highlighted the endothelial nature of lymphatic channels. Patient was disease free 6 months post surgery and is on regular follow up till date.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"35 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.18231/j.ijpo.2024.022
Kavita Somani, Pretty Singh, Sujatha Poduval
Pleomorphic adenoma (PA) of external auditory canal is an extremely rare benign neoplasm of uncertain origin with only few reported cases in the literature. It’s always challenging to diagnose pleomorphic adenoma of external auditory canal due to its rarity, unusual location as well as nonspecific symptoms mimicking more prevalent benign and malignant lesion of this site. Due to its premalignant nature and chances of recurrence, this case highlights the importance of Pleomorphic Adenoma as differential diagnosis in patient presenting with external auditory canal masses and necessity of complete surgical excision. This case report of 52 years male describes the clinical presentation, histopathological features and immunohistochemical findings of pleomorphic Adenoma of external auditory canal with review of literature emphasizing the diagnostic and therapeutic challenges associated with neoplasm.
{"title":"Pleomorphic adenoma of external auditory canal: A common tumor at an uncommon site","authors":"Kavita Somani, Pretty Singh, Sujatha Poduval","doi":"10.18231/j.ijpo.2024.022","DOIUrl":"https://doi.org/10.18231/j.ijpo.2024.022","url":null,"abstract":"Pleomorphic adenoma (PA) of external auditory canal is an extremely rare benign neoplasm of uncertain origin with only few reported cases in the literature. It’s always challenging to diagnose pleomorphic adenoma of external auditory canal due to its rarity, unusual location as well as nonspecific symptoms mimicking more prevalent benign and malignant lesion of this site. Due to its premalignant nature and chances of recurrence, this case highlights the importance of Pleomorphic Adenoma as differential diagnosis in patient presenting with external auditory canal masses and necessity of complete surgical excision. This case report of 52 years male describes the clinical presentation, histopathological features and immunohistochemical findings of pleomorphic Adenoma of external auditory canal with review of literature emphasizing the diagnostic and therapeutic challenges associated with neoplasm.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"69 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140699856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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