Journal of Evidence-Based Dental Practice最新文献

{"title":"THE USAGE AND REPORTING OF DENTAL PATIENT-REPORTED OUTCOMES AMONG SYSTEMATIC REVIEWS IN ORTHODONTICS: A METHODOLOGICAL STUDY","authors":"QI WANG ,&nbsp;ZHENDONG TAO ,&nbsp;TINGTING ZHAO ,&nbsp;DANCHEN QIN ,&nbsp;HONG HE ,&nbsp;FANG HUA","doi":"10.1016/j.jebdp.2024.102049","DOIUrl":"10.1016/j.jebdp.2024.102049","url":null,"abstract":"<div><h3>Objective</h3><div>To summarize and analyze the usage and reporting of dental patient-reported outcomes (dPROs) within systematic reviews (SRs) published in 5 leading orthodontic journals between 2015 and 2023.</div></div><div><h3>Methods</h3><div>A manual search was conducted to identify intervention (therapeutic or preventive) involved SRs published in selected journals between 2015 and 2023 from the official online archives. Two authors independently and in duplicate extracted the characteristics of each included SR, recording both the usage of dPROs in the Methods sections and the reporting of dPROs in the Results sections.</div></div><div><h3>Results</h3><div>A total of 244 SRs were found eligible and included, of which 81 (33.2%) included dPROs. Out of the 81 SRs, 19 (23.5%) described dPROs in the Methods sections, 6 (7.4%) reported dPROs exclusively in the Results sections, and 56 (69.1%) included dPROs in both sections. In the 75 SRs that stated dPROs in their Methods sections, 38 (50.7%) identified them as primary outcomes, while 37 (49.3%) considered them secondary outcomes. Among the 62 SRs that reported dPROs in the Results section, 17 (27.4%) performed quantitative synthesis, and the remaining 45 (72.6%) conducted only qualitative synthesis. A total of 26 dPROMs were identified, of which only 11 were included in meta-analyses.</div></div><div><h3>Conclusions</h3><div>Only about one-third of SRs published in leading orthodontic journals included dPROs. It is recommended that researchers consider the usage of dPROs and dPROMs during the design and registration stages of orthodontic SRs and ensure transparent reporting of the results, thus facilitating evidence-based practice and shared decision-making in clinical care.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102049"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT BY ORAL HEALTH PROFESSIONALS OF PATIENT-REPORTED OUTCOMES IN OBSTRUCTIVE SLEEP APNEA","authors":"NATHALIA CAROLINA FERNANDES Fagundes,&nbsp;CARLOS FLORES-MIR","doi":"10.1016/j.jebdp.2024.102045","DOIUrl":"10.1016/j.jebdp.2024.102045","url":null,"abstract":"<div><div>Oral health professionals, including general dentists and orthodontists, may participate in the provision of care to adults and children with obstructive sleep apnea (OSA) when referred by a sleep medicine specialist. The use of oral appliances (OA) has been presented as a possible management option for mild obstructive sleep apnea among adults. In children, although oral interventions are not supported as a first-line stand-alone management option for OSA, short-term studies have suggested an improvement in sleep signs and symptoms in milder cases. The monitoring of management outcomes from OA interventions is essential to monitor OSA conditions. Due to the chronic nature of OSA, the measure of dental patient-reported outcomes (dPROs) will likely help to understand interplaying factors that may influence the effectiveness of OA interventions among subjects with OSA. This narrative review discusses the current evidence regarding main dPROs in OSA, evaluation methods, and the contribution of oral health professionals in assessing it for both children and adults. The main dPROs assessed among OA users include quality of life, treatment adherence, and side effects. The use of validated tools to measure dPROs must be preferred when available. Overall, the clinical assessment of dPROs by oral health professionals is likely beneficial to monitoring OSA management outcomes and must be encouraged as part of an interdisciplinary approach led by the sleep physician.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102045"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DENTAL PATIENT-REPORTED OUTCOMES UPDATE 2024","authors":"FANG HUA","doi":"10.1016/j.jebdp.2025.102122","DOIUrl":"10.1016/j.jebdp.2025.102122","url":null,"abstract":"<div><div>As the medical field develops rapidly towards evidence-based, personalized and intelligent care, patient-reported outcomes (PRO) related research is becoming increasingly refined in terms of coverage, precision and practicability. In order to help improve the quality and quantity of patient-centered evidence in dentistry and to further promote the wide and standard use of dental patient-reported outcomes (dPROs) and dental patient-reported outcome measures (dPROMs), the <em>Journal of Evidence-Based Dental Practice</em> has put together this Special Issue, the fourth of a series entitled Dental Patient-Reported Outcomes Update.</div><div>A total of 7 solicited articles are included in this issue. To put them into a broader perspective, this review provides a concise summary of key, selected PRO and dPRO articles published during 2024. A brief introduction to those articles included in this Special Issue follows. Four main domains are covered in this Special Issue: (i) dPROs and general health, (ii) standardization of dPRO-related methodology, (iii) methodological considerations in dPRO-related research, and (iv) current usage of dPROs and dPROMs in published research.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 1","pages":"Article 102122"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LOW-QUALITY EVIDENCE SUGGESTS SKELETAL ANCHORAGE MAY PROVIDE SHORT-TERM CORRECTION OF ANTERIOR OPEN BITE","authors":"ZORAN JEZDIC (Reviewers),&nbsp;MARKO LAZIC,&nbsp;ALEKSANDAR JAKOVLJEVIC","doi":"10.1016/j.jebdp.2025.102129","DOIUrl":"10.1016/j.jebdp.2025.102129","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Orthodontic correction of anterior open bite using skeletal anchorage: systematic review and meta-analysis. Kwon TG, Elnagar MH, Shirazi S, Goben AH, Miloro M, Han MD. Int J Oral Maxillofac Surg. 2024 May;53(5):393-404.</div></div><div><h3>Source of Funding</h3><div>The authors did not report funding for this investigation.</div></div><div><h3>Type of Study/Design</h3><div>Systematic Review with Meta-Analysis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102129"},"PeriodicalIF":4.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROPHYLACTIC ANTIBIOTIC USE IN LOWER THIRD MOLAR SURGERY MAY REDUCE DRY SOCKET AND INFECTIONS, BUT EVIDENCE REMAINS WEAK","authors":"OMER WALEED MAJID (Reviewer)","doi":"10.1016/j.jebdp.2025.102128","DOIUrl":"10.1016/j.jebdp.2025.102128","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Camps-Font O, Sábado-Bundó H, Toledano-Serrabona J, Valmaseda-de-la-Rosa N, Figueiredo R, Valmaseda-Castellón E. Antibiotic prophylaxis in the prevention of dry socket and surgical site infection after lower third molar extraction: a network meta-analysis. Int J Oral Maxillofac Surg. 2024;53(1):57-67.</div></div><div><h3>Source of Funding</h3><div>None declared.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review with network meta-analysis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102128"},"PeriodicalIF":4.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF OZONE THERAPY IN THE TREATMENT OF TEMPOROMANDIBULAR DISORDERS: A SYSTEMATIC REVIEW","authors":"Tássia T. Machado ,&nbsp;Ana Carolina S. Machado ,&nbsp;Rodrigo L. Poluha ,&nbsp;Leilane S. Proença ,&nbsp;Nikolaos Christidis ,&nbsp;Carlos A. Parada ,&nbsp;Giancarlo De la Torre Canales ,&nbsp;Cláudia H. Tambeli","doi":"10.1016/j.jebdp.2025.102127","DOIUrl":"10.1016/j.jebdp.2025.102127","url":null,"abstract":"<div><h3>Background</h3><div>Temporomandibular disorders (TMD) refer to a range of conditions affecting the temporomandibular joints (TMJ), masticatory muscles, and related structures, bothering around 12% of the population. This systematic review aims to answer whether ozone therapy effectively reduces TMD-related symptoms.</div></div><div><h3>Methods</h3><div>A systematic electronic search of 6 databases was conducted on July 15th, 2021, and updated on November 17th, 2023. Only clinical trials published in Portuguese, English, or Spanish were selected, with no restriction to the year of publication. Animal studies, retrospective studies, case reports, review papers, meta-analysis, and ozone therapy applications outside the orofacial region were excluded. The risk of bias analysis was performed following the Cochrane Collaboration tool, RoB 2.</div></div><div><h3>Results</h3><div>Of the 315 articles identified in the search, only 7 studies were included in this review. Two studies were considered low risk of bias, 2 with some concerns, and 3 as high risk of bias. Ozone therapy, applied to both articular and muscular TMDs, has been shown to reduce pain intensity and palpatory pain, and improve pressure pain thresholds and mandibular range of motion.</div></div><div><h3>Conclusion</h3><div>Ozone therapy emerges as a potential therapy for reducing TMD-related symptoms. However, the current evidence lacks robustness, and further high-quality randomized controlled trials are necessary to enhance the existing evidence base.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102127"},"PeriodicalIF":4.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF STEM CELLS IN ENDODONTIC REGENERATION: A SYSTEMATIC REVIEW","authors":"NAUSHEEN AGA MClinDent ,&nbsp;SCOTT McGregor MSc ,&nbsp;SARAH JONES PhD ,&nbsp;IAN ELLIS ,&nbsp;MARCO TATULLO PhD ,&nbsp;MUNA EISA MOHAMED HASSAN PhD ,&nbsp;MOHAMMAD ISLAM PhD","doi":"10.1016/j.jebdp.2025.102125","DOIUrl":"10.1016/j.jebdp.2025.102125","url":null,"abstract":"<div><h3>Introduction</h3><div>Regenerative endodontic procedures (REPs) aim to regenerate structural and functional integrity of necrosed or infected dental pulp, while promoting root development and closure. Conventional treatment methods often fail to regenerate dental pulp tissues effectively. This systematic review investigates the efficacy of stem cell therapy in REPs.</div></div><div><h3>Methodology</h3><div>An electronic search was conducted on the following research databases and registers: PubMed (includes MEDLINE and PubMed Central), Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and ClinicalTrials.gov. The study was registered in PROSPERO and PRISMA guidelines were followed to report the review. 19 original studies comprising 1 randomized clinical trial and 18 animal studies were included after applying inclusion and exclusion criteria. The studies evaluated different types of endodontic procedures, including pulp capping, pulpotomy, pulpectomy, and furcation repair, using various types of mesenchymal stem cells, such as dental pulp stem cells, bone marrow-derived stem cells and umbilical cord mesenchymal stem cells (UCMSCs). The outcomes assessed in the studies included pulpal regeneration, resolution of periapical radiolucency, and restoration of tooth vitality. The Systematic Review Center for Laboratory and Animal Experimentation (SYRCLE) and Risk of Bias 2.0 was used for assessing the risk of bias in animal studies and randomized trials, respectively.</div></div><div><h3>Results</h3><div>The findings indicate that stem cell therapy holds promise for inducing dental pulp regeneration. However, synthesizing the overall efficacy of stem cell therapy compared to conventional methods remains challenging due to variations in methodologies and outcome measures used in animal studies. Despite these inconsistencies, most animal studies reported positive results for pulpal regeneration, regardless of the stem cell type, scaffold type or animal model used. Notably, a clinical trial utilizing umbilical cord mesenchymal stem cells (UCMSCs) combined with platelet-poor plasma demonstrated favorable outcomes in dental pulp revascularization and reperfusion.</div></div><div><h3>Conclusion</h3><div>The long-term safety and clinical efficacy of stem cell therapy in regenerative endodontic procedures (REPs) require validation through randomized clinical trials before widespread clinical adoption.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102125"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF LOW-LEVEL LIGHT THERAPY ON PAIN AND RELATED LESIONS IN PATIENTS WITH ORAL LICHEN PLANUS: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"CHENGHUI LU M.Med ,&nbsp;LANQING MO M.B.B.S ,&nbsp;XIN LI M.Sc ,&nbsp;GUANHUAN DU Ph.D ,&nbsp;ZHENGQUAN CHEN M.Sc ,&nbsp;FAN WU B.M ,&nbsp;LILI CAI B.M ,&nbsp;QING DU Ph.D ,&nbsp;GUOYAO TANG Ph.D","doi":"10.1016/j.jebdp.2025.102126","DOIUrl":"10.1016/j.jebdp.2025.102126","url":null,"abstract":"<div><h3>BACKGROUND</h3><div>Oral lichen planus (OLP) is a relatively common immunological mucocutaneous disease that causes pain, burning sensations and poor quality of life. The use of low-level light therapy (LLLT) to treat OLP is still debated. This systematic review and meta-analysis aimed to systematically and quantitatively assess the efficacy of LLLT in the treatment of OLP.</div></div><div><h3>METHODS</h3><div>The PubMed, Embase, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Cochrane Library, and Web of Science electronic databases were searched up to February 28, 2023, to identify randomized controlled trials (RCTs) examining the use of LLLT in OLP patients reporting pain or other outcomes. The mean difference (MD) or <em>log</em> risk ratio (<em>log</em> RR) with 95% confidence intervals (<em>CI</em>s) were estimated separately for each outcome to determine the effect sizes. Subgroup analysis was used to detect the sources of heterogeneity. Sensitivity analysis was used to test the robustness of the pooled results. Funnel plots, Egger's test, and Begg's test were used to test publication bias. All the statistical analyses were performed using Stata 16.0 software. A graph of risk of bias was drawn using RevMan 5.4.1 software for the assessment of bias.</div></div><div><h3>RESULTS</h3><div>A total of twelve RCTs were included in this systematic review, 7 of which were also included in the meta-analysis. Among the included studies, 1 had a low risk of bias, whereas 7 had an unclear risk of bias. The meta-analysis results indicated that LLLT significantly improved long-term analgesic efficacy (over 12 weeks posttreatment, measured by the visual analogue scale; MD = -1.20, 95% <em>CI</em> -2.01 to -0.38, <em>P</em> &lt; .001), whereas no significant changes were observed in either the short term (MD = -0.68, 95% <em>CI</em> -1.38 to 0.01, <em>P</em> = .05) or the medium term (MD = -0.89, 95% <em>CI</em> -1.96 to 0.17, <em>P</em> = .10). Furthermore, LLLT improved the clinical severity of lesions (as assessed by the biopsy sign scores or reticular atrophic erosive scores; MD = -1.13, 95% <em>CI</em> -1.62 to -0.63, <em>P</em> &lt; .001) and reduced the recurrence rate (<em>log</em> RR = -1.34, 95% <em>CI</em> -2.30 to -0.37, <em>P</em> = .01). Additionally, there were no statistically significant differences in the clinical response rate (measured by efficacy indices; <em>log</em> RR = -0.12, 95% <em>CI</em> -0.37 to 0.13, <em>P</em> = .35). No adverse events related to LLLT were reported.</div></div><div><h3>CONCLUSION</h3><div>LLLT appears to alleviate pain, enhance the clinical outcomes of OLP lesions, and lower the likelihood of relapse in OLP patients. Future research should focus on longer intervention courses, larger sample sizes, and multidisciplinary intervention designs.</div></div><div><h3>SYSTEMATIC REVIEW REGISTRATION</h3><div>This meta-analysis was registered on PROSPERO (CRD42023384852).</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102126"},"PeriodicalIF":4.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIPLAQUE AND ANTIGINGIVITIS EFFECTS OF A NOVEL ORAL CARE REGIMEN FEATURING STANNOUS FLUORIDE TOOTHPASTE, A UNIQUE TOOTHBRUSH, AND CETYLPYRIDINIUM CHLORIDE MOUTHWASH: A RANDOMIZED CLINICAL TRIAL","authors":"FARID AYAD ,&nbsp;MAHA HETATA ,&nbsp;RABAB AHMED ,&nbsp;TAKAHIDE OKAI ,&nbsp;GOKUL GOVINDARAJU ,&nbsp;LUIS R. MATEO ,&nbsp;MARIA RYAN ,&nbsp;BAYARDO GARCÍA-GODOY","doi":"10.1016/j.jebdp.2025.102123","DOIUrl":"10.1016/j.jebdp.2025.102123","url":null,"abstract":"<div><h3>Background</h3><div>Antibacterial ingredients for oral care products are typically measured through single product forms. This study assessed the overall health outcome of using multiple forms: a stabilized stannous fluoride toothpaste, an enhanced cetylpyridinium chloride mouthwash and a unique toothbrush to deliver antibacterial performance.</div></div><div><h3>Methods</h3><div>A 12-week, single-center, phase III, masked, 2-arm, parallel-group, randomized controlled trial was conducted to assess the reduction of established dental plaque and gingivitis with a novel antibacterial oral regimen comprised of 0.454% stannous fluoride toothpaste stabilized with nitrate and phosphates, 0.075% cetylpyridinium chloride and 0.28% zinc lactate mouthwash, and rapid foaming manual toothbrush compared to a nonantibacterial commercially available regimen of toothpaste containing 0.76% sodium monofluorophosphate, no mouthwash, and commercially available manual toothbrush to represent standard toothbrushing practices.</div></div><div><h3>Results</h3><div>Adherence to this novel oral care regimen provided significant reduction in plaque and gingivitis compared to the control starting at 1 week (<em>P</em> &lt; .01) and continuing over 12 weeks (<em>P</em> &lt; .001) across all plaque and gingival score indices. At week 1, participants in the Antibacterial Regimen Group showed 15 times more plaque reduction than control (<em>P</em> &lt; .001). After 3 weeks of regimen adherence, 100% of Antibacterial Regimen participants had improved gingival index scores compared to baseline.</div></div><div><h3>Conclusions</h3><div>Within the limitations of the study, the results showed statistically significantly reduced gingival inflammation and improved plaque control from 1 week continuing through 12 weeks of adherence to this novel oral care regimen compared to standard toothbrushing practices.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102123"},"PeriodicalIF":4.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THREE YEARS CLINICAL ASSESSMENT OF LOW CONCENTRATION DIMETHYL SULFOXIDE PRIMER IN NON CARIOUS CERVICAL LESIONS: A RANDOMIZED CONTROLLED TRIAL","authors":"OMAR ABDELAZIZ ISMAIL DDS, MSc ,&nbsp;OLFAT ELSAYED HASSANEIN DDS, Ph.D. ,&nbsp;RANDA HAFEZ DDS, Ph.D. ,&nbsp;MAI MAMDOUH DDS, Ph.D. ,&nbsp;OMAR SHAALAN DDS, Ph.D. ,&nbsp;ARZU TEZVERGIL-MUTLUAY DDS, Ph.D. FADM","doi":"10.1016/j.jebdp.2025.102124","DOIUrl":"10.1016/j.jebdp.2025.102124","url":null,"abstract":"<div><h3>Objectives</h3><div>to evaluate the clinical effectiveness of 1% dimethyl-sulfoxide (DMSO/H₂O) dentin pretreatment on the clinical performance of 2-step etch-rinse adhesive after 36-months of a follow-up.</div></div><div><h3>Methods</h3><div>Twenty-nine patients with 82 non carious-cervical lesions NCCLs were eligible for the study. NCCLs were randomly distributed into 2 equal groups. Both groups were acid etched then bonded with (Single-bond2, 3M-ESPE) and restored with a nanohybrid composite (Z350XT, 3M-ESPE) under rubber-dam isolation. Only for the intervention group 1% DMSO/H₂O was applied for 60s then blot dried after etching and before bonding. The restorations were evaluated at baseline, 12-, 24-, and 36-months using FDI criteria for evaluation of the restoration. For the statistical analysis, intergroup comparison between interventions was performed using Chi-Square-test (<em>P</em> ≤ .05), intragroup comparison within each intervention was performed using the Cochran's Q-test (<em>P</em> ≤ .0083).</div></div><div><h3>Results</h3><div>In the current study, intergroup comparison between both groups at baseline and after 12, 24 and 36 months showed no statistically significant differences for all tested outcomes (<em>P</em> &gt; .05), except for marginal discoloration at 36 months, where there was statistically significant difference (<em>P</em> &lt; .05) favoring DSMO. Intragroup comparison within control revealed statistically significant deterioration through time (<em>P</em> &lt; .001) for all tested parameters, also within DSMO there was statistically significant change through time (<em>P</em> &lt; .0083).</div></div><div><h3>Conclusion</h3><div>The clinical performance of a 2-step etch-rinse adhesive in combination with 1% DMSO pretreatment was better than the control without pretreatment. Longer follow-up and higher concentrations of DMSO pretreatment should be evaluated in the future.</div></div><div><h3>Clinical Significance</h3><div>Several laboratory studies showed that DMSO pretreatment improves the hybrid layer quality and integrity. However, this clinical trial gave the proof of the clinical effectiveness of this protocol after 36-months follow-up.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102124"},"PeriodicalIF":4.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}