Terrestrial water storage (TWS) in China, with the world's largest irrigated expanse and extensive mid-low latitude glaciers, is essential for effective water resource management and socioeconomic risk adaptation. However, the responses of TWS to human intervention and climate change, both during historical periods and under future scenarios, remain inadequately quantified. We reconstruct and project long-term TWS using a data-driven framework that integrates remote sensing, Earth system model (ESM) and machine learning. Our reconstructed record reveals an amplified TWS decline in China's drylands and a moderate yet persistent TWS reduction in glacier regions during 1985–2015, accentuated since the 21st century with a 13% increase in affected areas. TWS changes in drylands are primarily attributed to human irrigation (