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A Self-Adaptive weighted-average wire-length model for VLSI global placement VLSI全局布线的自适应加权平均线长模型
Pub Date : 2023-11-14 DOI: 10.22541/au.169993686.63760519/v1
Yuanxiao Chi, Zhijun Wang, Liping Liang, Xin Qiu
Global placement roughly decides the location of units in the very large-scale integrated (VLSI) and fundamentally determines the quality of physical design. Thus, it’s desirable to find an efficient method to solve the global placement problem. Global placement solves the problem by minimizing the total half-perimeter wirelength (HPWL) under density constraints. However, the non-differentiability of HPWL prevents advanced gradient-based methods from being applied to global placement. Therefore, smooth wirelength models have been proposed to approximate HPWL. Among all the models, weighted-average wirelength (WAWL) performs the best. In this letter, we propose an improved self-adaptive weighted-average wirelength (SaWAWL) model to further fit the HPWL. Instead of setting a generic γ for all nets in the design, the new model enables each net to adaptively adjust their respective γ according to their real length, thus can better approximate HPWL to achieve higher-quality placement results. Based on the SaWAWL and the framework of DREAMPlace, a global placer is implemented. Experimental results show that HPWL on open-source benchmarks is reduced by up to 6.56% with an average of 3.74%, which proves that our model can achieve better performance than the current state-of-the-art WAWL.
全局布局大致决定了超大规模集成电路(VLSI)中单元的位置,并从根本上决定了物理设计的质量。因此,寻找一种有效的方法来解决全局布局问题是很有必要的。全局布局通过在密度限制下最小化总半周长(HPWL)来解决问题。然而,HPWL的不可微性阻碍了基于梯度的高级方法应用于全局定位。因此,我们提出了平滑长度模型来近似HPWL。在所有模型中,加权平均波长(WAWL)模型表现最好。在这篇文章中,我们提出了一种改进的自适应加权平均波长(SaWAWL)模型来进一步拟合HPWL。新模型没有在设计中为所有网设置通用的γ,而是使每个网能够根据其实际长度自适应调整各自的γ,从而可以更好地近似HPWL,从而获得更高质量的放置结果。基于SaWAWL和DREAMPlace框架,实现了一个全局placer。实验结果表明,在开源基准测试中,HPWL降低了6.56%,平均降低了3.74%,证明我们的模型可以达到比目前最先进的WAWL更好的性能。
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引用次数: 0
Heavy Metal Stress and Mitogen Activated Kinase Transcription Factors in Plants: Exploring Heavy Metal-ROS Influences on Plant Signaling Pathways 植物重金属胁迫和丝裂原活化激酶转录因子:重金属- ros对植物信号通路的影响
Pub Date : 2023-11-14 DOI: 10.22541/au.169998555.59756936/v1
Lee-Ann Niekerk, Arun Gokul, Gerhard Basson, Mihlali Badiwe, Mbukeni Nkomo, Ashwil Klein, Marshall Keyster
Due to their stationery nature, plants are exposed to a diverse range of biotic and abiotic stresses, of which heavy metals stress poses as one of the most detrimental abiotic stresses, targeting crucial and vital processes. Heavy metals instigate the over-production of reactive oxygen species (ROS), and in order to mitigate the adverse effects of ROS, plants induce multiple defence mechanisms. Besides the negative implications of overproduction of ROS, these molecules play a multitude of signaling roles in plants, acting as a central player in the complex signaling network of cells. One of the signaling mechanisms it is involved in is the mitogen-activated protein kinase (MAPK) cascade, a signaling pathway used to transduce extracellular stimuli into intracellular responses. Plant MAPKs have been implicated in signaling of stresses, phytohormones and cell cycle cues. However, the influence of various heavy metals on MAPKs activation has not been well documented. In this review, we will attempt to address and summarize several aspects related to various heavy metal-induced ROS signaling, how these signals activate the MAPK cascade and the downstream transcription factors that instigates the plants response to these heavy metals. Moreover, we will highlight a modern research methodology that could characterize the novel genes associated with MAPKs and their roles in heavy metal stress.
由于它们的文具性质,植物暴露于各种生物和非生物胁迫下,其中重金属胁迫是最有害的非生物胁迫之一,针对关键和重要的过程。重金属刺激活性氧(ROS)的过量产生,为了减轻ROS的不利影响,植物诱导多种防御机制。除了ROS过量产生的负面影响外,这些分子在植物中还发挥着多种信号作用,在细胞复杂的信号网络中扮演着核心角色。它参与的信号机制之一是丝裂原活化蛋白激酶(MAPK)级联,这是一种用于将细胞外刺激转化为细胞内反应的信号通路。植物MAPKs与胁迫信号、植物激素和细胞周期信号有关。然而,各种重金属对MAPKs活化的影响还没有很好的文献记载。在这篇综述中,我们将尝试解决和总结与各种重金属诱导的ROS信号有关的几个方面,这些信号如何激活MAPK级联以及下游转录因子,从而引发植物对这些重金属的反应。此外,我们将重点介绍一种现代研究方法,该方法可以表征与mapk相关的新基因及其在重金属胁迫中的作用。
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引用次数: 0
New-onset Sarcoidosis in a Patient with Long COVID 长COVID新发结节病1例
Pub Date : 2023-11-14 DOI: 10.22541/au.169996530.07036487/v1
Guillermo Rodriguez-Nava, Vanessa El Kamari, Goar Egoryan, Hector Bonilla
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引用次数: 0
Multi-decadal trends of low clouds at the Tropical Montane Cloud Forests 热带山地云雾林低云的多年代际变化趋势
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000400.07669392/v1
J. Antonio Guzmán Q., Hendrik F. Hamann, G. Arturo Sanchez-Azofeifa
Clouds are critical to the biodiversity and function of Tropical Montane Cloud Forests (TMCF). These ecosystems provide vital services to humanity and are considered hotspots of endemism, given that the number of species is restricted to their microclimates. Cloudiness (e.g., the fraction of low-clouds) in these ecosystems is projected to decline owing to global warming, but recent temporal trends remain unclear. Here, we evaluated trends in low-cloud fractions (CF) and other Essential Climatic Variables (ECV) (e.g., surface temperature, pressure, soil moisture, and precipitation) for 521 sites worldwide with TMFCs from 1997 to 2020. Thus, we hypothesize that recent traces of global warming over the last few decades have led to decreases in low-cloud cover on TMCFs. The previous study was also evaluated globally and among biogeographic realms to identify regional trends. We computed trends by aggregating hourly observations from ERA5 reanalysis and CHIRPS into annual averages and then used linear regressions to calculate slopes (i.e., rate of change) (Δ, year). Our results suggest that CF trends at the TMCFs range between -64.7 ×10 and 51.4 ×10 CF year, revealing that 70% of the assessed sites have experienced reductions in CF. Declines in low-clouds in these ecosystems are 253% more severe than tropical landmasses when peak values of density distribution are compared (TMCFs: -7.8 ×10CF year; tropical landmasses -2.3 ×10 CF year). Despite this, CF trends tend to differ among biogeographic realms, as those TMCFs from the Neotropics and Indomalayan realms have the most pronounced declines. Decreases in CF were also associated with increases in surface temperature and pressure and decreases in soil moisture, revealing that the TMCF’s climate is changing to warmer environments. These climatic shifts may represent a fingerprint of global change on TMCFs, highlighting a current threat to species and essential ecosystem services that these ecosystems provide.
云对热带山地云雾林(TMCF)的生物多样性和功能至关重要。这些生态系统为人类提供了至关重要的服务,由于物种数量受其小气候的限制,它们被认为是特有的热点地区。由于全球变暖,预计这些生态系统中的云量(如低云的比例)将减少,但近期的时间趋势仍不清楚。在这里,我们评估了1997年至2020年全球521个具有tmfc的站点的低云分数(CF)和其他基本气候变量(ECV)(如地表温度、压力、土壤湿度和降水)的趋势。因此,我们假设最近几十年全球变暖的痕迹导致了tmcf低云覆盖的减少。之前的研究还在全球和生物地理领域之间进行了评估,以确定区域趋势。我们通过将ERA5再分析和CHIRPS的每小时观测数据汇总为年平均值来计算趋势,然后使用线性回归来计算斜率(即变化率)(Δ, year)。我们的研究结果表明,在tmcf的CF趋势范围在-64.7 ×10和51.4 ×10CF年之间,表明70%的评估站点经历了CF的减少。当密度分布的峰值比较时,这些生态系统中低云的下降比热带大陆严重253% (tmcf: -7.8 ×10CF年;热带大陆-2.3 ×10 CF年)。尽管如此,在不同的生物地理领域,气候变化趋势是不同的,因为那些来自新热带和印度洋地区的tmcf下降最为明显。CF的减少还与地表温度和压力的增加以及土壤水分的减少有关,这表明TMCF的气候正在向更温暖的环境变化。这些气候变化可能代表了全球变化对tmcf的影响,突出了这些生态系统提供的物种和基本生态系统服务当前面临的威胁。
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引用次数: 0
Developing an Explainable Variational Autoencoder (VAE) Framework for Accurate Representation of Local Circulation in Taiwan 发展可解释的变分自编码器(VAE)架构,以准确表征台湾地区环流
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000348.85507974/v1
Min-Ken Hsieh, Chien-Ming Wu
This study develops an explainable variational autoencoder (VAE) framework to efficiently generate high-fidelity local circulation patterns in Taiwan, ensuring an accurate representation of the physical relationship between generated local circulation and upstream synoptic flow regimes. Large ensemble semi-realistic simulations were conducted using a high-resolution (2 km) model, TaiwanVVM, where critical characteristics of various synoptic flow regimes were carefully selected to focus on the effects of local circulation variations. The VAE was constructed to capture essential representations of local circulation scenarios associated with the lee vortices by training on the ensemble dataset. The VAE’s latent space effectively captures the synoptic flow regimes as controlling factors, aligning with the physical understanding of Taiwan’s local circulation dynamics. The critical transition of flow regimes under the influence of southeasterly synoptic flow regimes is also well represented in the VAE’s latent space.This indicates that the VAE can learn the nonlinear characteristics of the multiscale interactions involving the lee vortex. The latent space within VAE can serve as a reduced-order model for predicting local circulation using synoptic wind speed and direction. This explainable VAE ensures the accurate predictions of the nonlinear characteristics of multiscale interactions between synoptic flows and the local circulation induced by topography, thereby accelerating the assessments under various climate change scenarios.
本研究开发了一个可解释的变分自编码器(VAE)框架,以有效地生成高保真的台湾局地环流模式,确保生成的局地环流与上游天气流型态之间的物理关系的准确表示。利用高分辨率(2 km)模式台湾vvm进行了大集合半真实模拟,仔细选择了各种天气流型的关键特征,重点研究了局地环流变化的影响。通过对集合数据集的训练,构建了VAE来捕捉与背风涡相关的局地环流情景的基本表征。VAE的潜在空间有效地捕捉了天气流动状态作为控制因素,与台湾当地环流动力学的物理理解一致。受东南天气气流影响的气流型的临界转变也在VAE的潜在空间中得到了很好的体现。这表明VAE可以学习到涉及背风涡的多尺度相互作用的非线性特征。VAE潜空间可以作为一个降阶模型,利用天气风速和风向预测局地环流。这种可解释的VAE保证了对地形诱导的天气流与局地环流多尺度相互作用的非线性特征的准确预测,从而加快了各种气候变化情景下的评估。
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引用次数: 0
Comparative study on the compression characteristics under mechanical and gas pressurization 机械加压与气体加压下压缩特性的比较研究
Pub Date : 2023-11-14 DOI: 10.22541/au.169998699.97868680/v1
Shicheng Wang, Xiaolei Guo, Hui Zhang, Yunfei Yang, Haifeng Lu, Haifeng Liu
Powder compression is essential in the storage and transportation processes. The compression characteristics of pulverized coal, rice husk and lignocellulose were compared under mechanical and gas pressurization respectively. The experimental results showed that the descending order of relative packing density was lignocellulose > rice husk > pulverized coal under mechanical pressurization, while an opposite trend was observed under gas pressurization. The effect of cohesion properties on compression results, such as inter-particle adhesion force and powder bed cohesion, was also investigated. For mechanical pressurization, the powder bed of cohesive biomass had higher void fraction, which was directly linked to larger relative packing density. On the contrary, gas permeated easily into the biomass powder bed, and the lower pressure drop decreased the compression capacity of gas pressurization. In addition, a model for predicting the relative packing density was proposed with an error of ± 5%.
粉末压缩在储存和运输过程中是必不可少的。分别比较了煤粉、稻壳和木质纤维素在机械加压和气体加压下的压缩特性。实验结果表明:相对堆积密度由大到小依次为木质纤维素;谷壳;煤粉在机械加压下,而在气体加压下则相反。研究了颗粒间黏结力和粉床黏结力等黏结力对压缩结果的影响。机械加压时,粘性生物质粉床孔隙率较高,其相对堆积密度较大。反之,气体容易渗透到生物质粉床中,压降越低,气体增压的压缩能力就越低。建立了相对堆积密度的预测模型,误差为±5%。
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引用次数: 0
Ventilation of the Arabian Sea Oxygen Minimum Zone by Persian Gulf Water 波斯湾水域对阿拉伯海最低氧区的通气
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000364.41564926/v1
Estel Font, Sebastiaan Swart, Gerd Bruss, Peter M. F. Sheehan, Karen J. Heywood, Bastien Yves Queste
Dense overflows from marginal seas are critical pathways of oxygen supply to the Arabian Sea Oxygen Minimum Zone (OMZ), yet these remain inadequately understood. Climate models struggle to accurately reproduce the observed extent and intensity of the Arabian Sea OMZ due to their limited ability to capture processes smaller than their grid scale, such as dense overflows. Multi-month repeated sections by underwater gliders off the coast of Oman resolve the contribution of dense Persian Gulf Water (PGW) outflow to oxygen supply within the Arabian Sea OMZ. We characterize PGW properties, seasonality, transport and mixing mechanisms to explain local processes influencing water mass transformation and oxygen fluxes into the OMZ. Atmospheric forcing at the source region and eddy mesoscale activity in the Gulf of Oman control spatiotemporal variability of PGW as it flows along the shelf of the northern Omani coast. Subseasonally, it is modulated by stirring and shear-driven mixing driven by eddy-topography interactions. The oxygen transport from PGW to the OMZ is estimated to be 1.3 Tmol yr over the observational period, with dramatic inter- and intra-annual variability (±1.6 Tmol yr). We show that this oxygen is supplied to the interior of the OMZ through the combined action of double-diffusive and shear-driven mixing. Intermittent shear-driven mixing enhances double-diffusive processes, with mechanical shear conditions (Ri<0.25) prevailing 14% of the time at the oxycline. These findings enhance our understanding of fine-scale processes influencing oxygen dynamics within the OMZ that can provide insights for improved modeling and prediction efforts.
来自边缘海域的密集溢流是向阿拉伯海氧气最小带(OMZ)供应氧气的关键途径,但这些途径仍未得到充分的了解。气候模式很难准确地再现观测到的阿拉伯海OMZ的范围和强度,因为它们捕捉比网格尺度小的过程的能力有限,例如密集的溢出。水下滑翔机在阿曼海岸进行了长达数月的重复探测,以解决波斯湾密集水(PGW)流出对阿拉伯海OMZ内氧气供应的贡献。我们描述了PGW的性质、季节性、运输和混合机制,以解释影响水质量转化和氧通量进入OMZ的局部过程。源区大气强迫和阿曼湾涡动中尺度活动控制着PGW沿阿曼北部海岸陆架流动时的时空变化。在亚季节中,由涡流-地形相互作用驱动的搅拌和剪切驱动混合对其进行调节。在观测期内,从PGW到OMZ的氧输运估计为1.3 Tmol /年,具有显著的年际和年内变率(±1.6 Tmol /年)。我们发现这种氧气是通过双扩散和剪切混合的共同作用提供给OMZ内部的。间歇剪切驱动的混合增强了双扩散过程,在氧斜岩中14%的时间存在机械剪切条件(Ri<0.25)。这些发现增强了我们对影响OMZ内氧动力学的精细过程的理解,可以为改进建模和预测工作提供见解。
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引用次数: 0
More Frequent Spaceborne Sampling of XCO2 Improves Detectability of Carbon Cycle Seasonal Transitions in Arctic-Boreal Ecosystems 更频繁的XCO2星载采样提高了北极-北方生态系统碳循环季节转换的可探测性
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000369.94748519/v1
Nicholas C Parazoo, Gretchen Keppel-Aleks, Stanley Sander, Brendan Byrne, Vijay Natraj, Mingzhao Luo, Jean-Francois Blavier, Leonard Dorsky, Ray Nassar
Surface, aircraft, and satellite measurements indicate pervasive cold season CO2 emissions across Arctic regions, consistent with a hyperactive biosphere and increased metabolism in plants and soils. A key remaining question is whether cold season sources will become large enough to permanently shift the Arctic into a net carbon source. Polar orbiting GHG satellites provide robust estimation of regional carbon budgets but lack sufficient spatial coverage and repeat frequency to track sink-to-source transitions in the early cold season. Mission concepts such as the Arctic Observing Mission (AOM) advocate for flying imaging spectrometers in highly elliptical orbits (HEO) over the Arctic to address sampling limitations. We perform retrieval and flux inversion simulation experiments using the AURORA mission concept, leveraging a Panchromatic imaging Fourier Transform Spectrometer (PanFTS) in HEO. AURORA simulations demonstrate the benefits of increased CO2 sampling for detecting spatial gradients in cold season efflux and improved monitoring of rapid Arctic change.
地面、飞机和卫星测量表明,北极地区普遍存在寒冷季节的二氧化碳排放,这与生物圈过度活跃以及植物和土壤代谢增加相一致。剩下的一个关键问题是,寒冷季节的碳源是否会变得足够大,从而永久地将北极变成一个净碳源。极轨温室气体卫星提供了对区域碳收支的可靠估计,但缺乏足够的空间覆盖和重复频率来跟踪冷季早期的汇源转换。像北极观测任务(AOM)这样的任务概念提倡在北极上空的高椭圆轨道(HEO)上飞行成像光谱仪,以解决采样限制。利用HEO中的全色成像傅立叶变换光谱仪(PanFTS),利用AURORA任务概念进行检索和通量反演模拟实验。AURORA模拟表明,增加CO2采样对于探测寒冷季节外排的空间梯度和改进对北极快速变化的监测是有益的。
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引用次数: 0
Updating the Crustal Fault Model for the 2023 National Seismic Hazard Model for Alaska 2023年阿拉斯加国家地震危险性模型的地壳断层模型更新
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000026.63675767/v1
Peter J Haeussler, Adrian M Bender, Peter M Powers, Rich D Koehler, Daniel S Brothers
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引用次数: 0
Translations Of Neural Networks based on Fuzzy Weights for Binary Keys within Delayed and Actual Time 基于模糊权重的神经网络在延迟和实际时间内的二进制密钥转换
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000021.14010690/v1
Amitesh Kumar Singam
The Key facts of Translations are meant to validated the Fuzzy Weights. Moreover, In our case Fuzzy weights are based on Logical Reasoning and Logical Thinking, even though fuzzy logics are not concerned with data rather it depends on thought process based on human brain Imitation. Generally, at some point mankind depends on his own creations and tries to understand its usage through Machine Language or so called Machine Teaching and this is were humans try to understand fuzzy concepts based on binary language, moreover this translations are meant to become complicated the more we go deeper but here comes our originality of introducing fuzzy weights or logic based on Switching Theory Logical design which produces binary keys instead of values, we concentrated on reducing complexity of Machine Teaching through fuzzy weights.
翻译的关键事实是为了验证模糊权重。此外,在我们的案例中,模糊权重是基于逻辑推理和逻辑思维的,尽管模糊逻辑与数据无关,但它依赖于基于人脑模仿的思维过程。一般来说,在某种程度上,人类依赖于自己的创造,并试图通过机器语言或所谓的机器教学来理解其用法,这是人类试图理解基于二进制语言的模糊概念,此外,这种翻译意味着我们越深入越复杂,但这里是我们引入模糊权重或逻辑的独创性基于交换理论逻辑设计,产生二进制密钥而不是值,我们专注于通过模糊权重来降低机器教学的复杂性。
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引用次数: 0
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