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Racial-Ethnic Disparities in Physical and Mental Health of U.S. Sexual and Gender Minority Adults 美国性和性别少数群体成年人身心健康的种族差异
Pub Date : 2023-11-15 DOI: 10.22541/au.170000834.42958476/v1
Luis Espinoza, Lucas Espinoza, Kim Nguyen-Finn, Leticia Nevarez Zavala
Lesbians, gays, bisexuals, and transgender individuals have persistent obstacles pertaining to their sexual orientation and gender identity, including but not limited to discrimination, prejudice, assault, limited access to healthcare, and inadequate social support. The present study investigates whether there are racial-ethnic differences in the physical and mental health (MH) of sexual and gender minorities (SGMs). Data from 28,345 adults who participated in the 2020 Behavioral Risk Factor Surveillance System answered questions regarding sexual orientation (SO), transgender identity (TI), physical health (PH), and MH. SO, and TI were associated with overall general health, acute MH, acute PH, and specific chronic conditions. SO, and TI were associated with acute MH, PH chronic conditions, and overall general health, but not acute PH. Bisexuals had more chronic conditions than heterosexuals and worse acute MH than heterosexuals. SO, and TI strongly predicted acute PH and MH status respectively. These findings can assist healthcare providers in developing strategies to reduce health disparities among SGMs.
女同性恋者、男同性恋者、双性恋者和跨性别者在性取向和性别认同方面持续存在障碍,包括但不限于歧视、偏见、攻击、获得医疗保健的机会有限以及社会支持不足。本研究旨在探讨性少数群体(SGMs)的身心健康(MH)是否存在种族差异。参与2020年行为风险因素监测系统的28345名成年人的数据回答了有关性取向(SO)、跨性别认同(TI)、身体健康(PH)和MH的问题。SO和TI与总体健康状况、急性MH、急性PH和特定慢性病相关。SO和TI与急性MH、PH慢性疾病和总体健康状况有关,但与急性PH无关。双性恋者比异性恋者有更多的慢性疾病,急性MH比异性恋者更严重。SO和TI分别预测急性PH和MH状态。这些发现可以帮助医疗保健提供者制定策略,以减少SGMs之间的健康差异。
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引用次数: 0
Designing, refining and reflecting on 3 years of daily evidence surveillance for Australia's living national COVID-19 guidelines 设计、完善和反思澳大利亚COVID-19全国活体指南的3年每日证据监测
Pub Date : 2023-11-15 DOI: 10.22541/au.170000956.66740754/v1
Steve McDonald, Tari Turner
Australia’s national living guidelines for COVID-19 were launched in April 2020 and include over 200 recommendations to guide the clinical care of patients with COVID-19. Until the guidelines were retired in August 2023, new evidence was continually monitored through daily surveillance. This paper describes how evidence surveillance was established (at a time when efforts to collate information on the novel coronavirus were in their infancy and often duplicative) and how it evolved throughout the pandemic. Among the wide range of sources monitored, the collections of COVID-19 research from leading medical journals, medRxiv preprints and PubMed auto alerts proved the most enduring in identifying time-critical and impactful evidence. The paper also explores how evidence was tracked and surveillance integrated into the overall evidence workflow by using messaging apps and communication platforms. Several factors contributed to the feasibility of daily surveillance, including the clearly defined scope of the guidelines; focusing efforts on maximum impact; minimising duplication by partnering with others; setting up simple but effective processes for managing evidence; and the value of continuous involvement of personnel from the outset. The example of Australia’s living COVID-19 guidelines has demonstrated the feasibility and essential role of daily evidence surveillance in maintaining COVID-19 living guidelines for over 3 years.
澳大利亚于2020年4月发布了《2019冠状病毒病国家生活指南》,其中包括200多项指导COVID-19患者临床护理的建议。在该指南于2023年8月退役之前,通过日常监测不断监测新的证据。本文描述了证据监测是如何建立的(当时整理新型冠状病毒信息的工作还处于起步阶段,而且往往是重复的),以及它在大流行期间是如何演变的。在监测的广泛来源中,来自领先医学期刊、medRxiv预印本和PubMed自动警报的COVID-19研究集合证明,在识别时间关键和有影响力的证据方面最持久。本文还探讨了如何通过使用消息应用程序和通信平台跟踪证据并将监视整合到整个证据工作流程中。有几个因素促成了每日监测的可行性,包括准则的明确界定范围;集中精力发挥最大影响;通过与他人合作,尽量减少重复;建立简单有效的证据管理程序;以及从一开始人员持续参与的价值。澳大利亚新冠肺炎生活指南的例子证明了日常证据监测在维持3年多新冠肺炎生活指南方面的可行性和重要作用。
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引用次数: 0
Molecular engineered xanthene-based AIE dyes for tunable fluorescence switch 分子工程黄原基AIE可调荧光开关染料
Pub Date : 2023-11-15 DOI: 10.22541/au.170000827.71841547/v1
Rui Guo, Wenhui Song, Jiyoung Yoo, Changyu Yoon, Yinhu Ai, Yan Yin, Jong Seung Kim, Weiying Lin
The dyes with the aggregation-induced emission (AIE) properties are significant for a wide range of studies. However, the existing AIE dyes still lack a readily tunable fluorescence switch. Herein, we described a type of structurally distinct dye family (named as XD dyes) with AIE properties. Significantly, the new XD dyes exhibit the advantageous feature over the traditional AIE fluorophores by possessing the intrinsic spirocyclization as a regulatable fluorescence switch. The AIE properties of XD dyes were examined by the spectroscopic studies, particle size analysis, transmission electron microscope, scanning electron microscope, and solid fluorescence. Furthermore, the quantum chemical calculation, molecular dynamics simulation and recombination energy calculation provide the insights into the structural characteristics and the aggregation process of XD dyes. The development of this unique class of dyes could afford new perception and insights for the development of supreme functional fluorescent dyes and probes.
具有聚集致发光(AIE)特性的染料具有广泛的研究意义。然而,现有的AIE染料仍然缺乏易于调节的荧光开关。本文描述了一种具有AIE特性的结构独特的染料家族(称为XD染料)。值得注意的是,新的XD染料具有固有的螺旋环化作为可调节的荧光开关,比传统的AIE荧光团具有优势。采用光谱学、粒度分析、透射电镜、扫描电镜和固体荧光等方法对XD染料的AIE性能进行了表征。此外,量子化学计算、分子动力学模拟和复合能计算为XD染料的结构特征和聚集过程提供了新的思路。这类独特染料的开发为开发高性能荧光染料和探针提供了新的认识和见解。
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引用次数: 0
Brute force prey metabarcoding to explore the diets of small invertebrates 蛮力猎物元条形码探索小型无脊椎动物的饮食
Pub Date : 2023-11-14 DOI: 10.22541/au.169994799.99897209/v1
Snorre Flo, Anna Vader, Kim Præbel
1. Prey metabarcoding has become a popular tool in molecular ecology for resolving trophic interactions at high resolution, from various sample types and animals. To date, most predator-prey studies of small-sized animals (<1 mm) have met the problem of overabundant predator DNA in dietary samples by adding blocking primers/peptide nucleic acids. These primers aim to limit the PCR amplification and detection of the predator DNA but may introduce bias to the prey composition identified by interacting with sequences that are similar to those of the predator. 2. Here we demonstrate the use of an alternative method to explore the prey of small marine copepods using whole-body DNA extracts and deep, brute force metabarcoding of an 18S rDNA fragment. 3. After processing and curating raw data from two sequencing runs of varying depth (0.4 and 5.4 billion raw reads), we isolated 1.3 and 52.2 million prey reads, with average depths of ~15 900 and ~120 000 prey reads per copepod individual, respectively. While data from both sequencing runs were sufficient to distinguish dietary compositions from disparate seasons, locations and copepod species, greater sequencing depth led to better separation of clusters. 4. As computation and sequencing are becoming ever more powerful and affordable, we expect the brute force approach to become a general standard for prey metabarcoding, as it offers a simple and affordable solution to consumers that are impractical to dissect or unknown to science.
1. 猎物元条形码已成为分子生态学中一个流行的工具,用于从各种样品类型和动物中以高分辨率解决营养相互作用。迄今为止,大多数对小型动物(1毫米)的捕食者-猎物研究都通过添加阻断引物/肽核酸来解决饮食样本中捕食者DNA过多的问题。这些引物旨在限制PCR扩增和对捕食者DNA的检测,但可能会对通过与捕食者DNA相似的序列相互作用确定的猎物组成引入偏见。2. 在这里,我们展示了使用一种替代方法来探索小型海洋桡足类动物的猎物,使用全身DNA提取和18S rDNA片段的深度蛮力元条形码。3.在处理和整理了两次不同深度测序(4亿和54亿原始读数)的原始数据后,我们分别分离了130万个和5220万个猎物读数,平均深度分别为每个桡足类个体约15 900和12万个猎物读数。虽然两次测序的数据都足以区分不同季节、地点和桡足类动物的饮食组成,但测序深度越深,聚类的分离就越好。4. 随着计算和排序变得越来越强大和负担得起,我们期望蛮力方法成为猎物元条形码的通用标准,因为它为消费者提供了一种简单而负担得起的解决方案,而这种解决方案是不切实际的或科学未知的。
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引用次数: 0
A biological dipole variability in the Indian Ocean 印度洋生物偶极变异性
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000399.94972609/v1
Kyung Min Noh, Jong-Seong Kug, Gayan Pathirana, Dong-Geon Lee, Huiji Lee
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引用次数: 0
Regimes of precipitation change over Europe and the Mediterranean 欧洲和地中海地区的降水变化
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000349.97043887/v1
Julie Camille André, Fabio D'Andrea, Philippe J Drobinski, Caroline Muller
The Mediterranean region is experiencing pronounced aridification and in certain areas higher occurrence of intense precipitation.In this work, we analyze the evolution of the rainfall probability distribution in terms of precipitating days (or “wet-days”) and all-days quantile trends, in Europe and the Mediterranean, using the ERA5 reanalysis.Looking at the form of wet-days quantile trends curves, we identify four regimes.Two are predominant: in most of Northern Europe the rainfall quantiles all intensify, while in the Mediterranean the low-medium quantiles are mostly decreasing as extremes intensify.The wet-days distribution is then modeled by a Weibull law with two parameters, whose changes capture the four regimes.Assessing the significance of the parameter changes over 1950–2020 shows that a signal on wet-days distribution has already emerged in Northern Europe (where the distribution shifts to more intense rainfall), but not yet in the Mediterranean, where the natural variability is stronger.We extend the results by describing the all-days distribution change as the wet-days’, plus a contribution from the dry-days frequency change, and study their relative contribution.In Northern Europe, the wet-days distribution change is the dominant driver, and the contribution of dry-days frequency change can be neglected for wet-days percentiles above about 50%.In the Mediterranean, however, the contribution to all-days change of wet-days distribution change is much smaller than the one of dry-days frequency.Therefore, in the Mediterranean the increase of dry-days frequency is crucial for all-days trends, even when looking at heavy precipitations.
地中海地区正在经历明显的干旱化,在某些地区,强降水的发生率更高。在这项工作中,我们使用ERA5再分析,分析了欧洲和地中海降雨概率分布在降水日数(或“湿润日数”)和全天分位数趋势方面的演变。通过观察雨天分位数趋势曲线的形式,我们发现了四种情况。两种情况占主导地位:在北欧大部分地区,降雨分位数都在增强,而在地中海,随着极端事件的加剧,低-中分位数大多在减少。然后用一个有两个参数的威布尔定律来模拟湿天分布,它的变化捕获了四种状态。对1950-2020年期间参数变化的重要性进行评估表明,北欧已经出现了湿润日分布的信号(那里的分布转向更强的降雨),但在自然变率更强的地中海尚未出现。我们将结果扩展为湿润日的分布变化加上干燥日频率变化的贡献,并研究了它们的相对贡献。在北欧,湿润日分布变化是主要驱动因素,对于湿润日百分比高于50%的地区,干燥日频率变化的贡献可以忽略不计。而在地中海,湿润日分布变化对全天变化的贡献远小于干旱日频率的贡献。因此,在地中海,干旱日频率的增加对全天趋势至关重要,即使在观察强降水时也是如此。
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引用次数: 0
Reflecting on Our Present Self-Awareness of Not Having Found Any Life Beyond Earth 反思我们目前没有在地球外发现任何生命的自我意识
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000013.32359841/v1
Jonathan H Jiang, Stuart Fisher Taylor, Nick Searra, Philip E. Rosen
The quest for finding extraterrestrial life has been a fascination for humanity for centuries, yet we have not yet found any concrete evidence of life beyond our planet, except for some hints of methane on Mars. It is essential to document this time of not having found any life to fully describe our perspective to other civilizations, anticipate how these events may change humanity, and appreciate the uncertainty of our knowledge about the universe.
几个世纪以来,寻找地外生命一直是人类的一大兴趣,但除了火星上有一些甲烷的迹象外,我们还没有发现任何地球以外存在生命的具体证据。有必要记录下这段没有发现任何生命的时期,以充分描述我们对其他文明的看法,预测这些事件可能如何改变人类,并认识到我们对宇宙知识的不确定性。
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引用次数: 0
Aerosol Atmospheric Rivers as Drivers of Extreme Poor Air Quality Events and Record PM2.5 Levels 气溶胶大气河流是极端恶劣空气质量事件和创纪录PM2.5水平的驱动因素
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000500.05855700/v1
Sudip Chakraborty, Bin Guan, Duane Edward Waliser, Arlindo M. daSilva, Jonathan H Jiang
This study investigates the impacts of aerosol atmospheric rivers (AARs) on extreme Particulate Matter 2.5 (PM2.5) levels (PM2.5 > 15mgm-3, as per the WHO) and on aerosol optical depth (AOD) extremes (AOD > 98th percentile) over the US and the globe, respectively, between 1997-2020. Results show that over various regions over the US, extreme PM2.5values are associated with AARs up to 70% of the time. Dust (sulfate) AARs are responsible for extreme PM2.5 levels over the southwestern (northeastern and the east coastal) US. Organic and black carbon AARs are associated with extreme PM2.5 levels over the Midwest region of the US. Globally, AARs are associated with 40-80% of the extreme AOD levels over the US, Sahel, Europe, Middle East, US, South America, East Asia, India, and South Africa. Such associations often lead to the highest or the second highest PM2.5 and AOD levels recorded over those stations between 1997-2020.
本研究探讨了气溶胶大气河流(AARs)对极端颗粒物2.5 (PM2.5)水平(PM2.5 >15毫克-3,根据世界卫生组织)和气溶胶光学深度(AOD)极端(AOD >在1997年至2020年期间,美国和全球分别超过了98个百分位。结果表明,在美国的各个地区,极端pm2.5值与AARs相关的时间高达70%。粉尘(硫酸盐)AARs是造成美国西南部(东北部和东部沿海)极端PM2.5水平的原因。有机碳和黑碳AARs与美国中西部地区的极端PM2.5水平有关。在全球范围内,美国、萨赫勒地区、欧洲、中东、美国、南美、东亚、印度和南非的40-80%的极端AOD水平与AARs有关。这种关联往往导致这些监测站在1997年至2020年间记录的PM2.5和AOD水平最高或次高。
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引用次数: 0
Exploring the Potential of Long Short-Term Memory Networks for Predicting Net CO2 Exchange Across Various Ecosystems With Multi-Source Data 利用多源数据探索长短期记忆网络预测不同生态系统净二氧化碳交换的潜力
Pub Date : 2023-11-14 DOI: 10.22541/essoar.170000018.89933793/v1
Chengcheng Huang, Wei He, Jinxiu Liu, Ngoc Tu Nguyen, Hua Yang, Yiming Lv, Hui Chen, Mengyao Zhao
Upscaling flux tower measurements based on machine learning (ML) algorithms is an essential approach for large-scale net ecosystem CO2 exchange (NEE) estimation, but existing ML upscaling methods face some challenges, particularly in capturing NEE interannual variations (IAVs) that may relate to lagged effects. With the capacity of characterizing temporal memory effects, the Long Short-Term Memory (LSTM) networks are expected to help solve this problem. Here we explored the potential of LSTM for predicting NEE across various ecosystems using flux tower data over 82 sites in North America. The LSTM model with differentiated plant function types (PFTs) demonstrates the capability to explain 79.19% (R2 = 0.79) of the monthly variations in NEE within the testing set, with RMSE and MAE values of 0.89 and 0.57 g C m-2 d-1 respectively (r = 0.89, p < 0.001). Moreover, the LSTM model performed robustly in predicting cross-site variability, with 67.19% of the sites that can be predicted by both LSTM models with and without distinguished PFTs showing improved predictive ability. Most importantly, the IAV of predicted NEE highly correlated with that in flux observations (r = 0.81, p < 0.001), clearly outperforming that by the random forest model (r = -0.21, p = 0.011). Among all nine PFTs, solar-induced chlorophyll fluorescence, downward shortwave radiation, and leaf area index are the most important variables for explaining NEE variations, collectively accounting for approximately 54.01% in total. This study highlights the great potential of LSTM for improving carbon flux upscaling with multi-source remote sensing data.
基于机器学习(ML)算法的通量塔升级测量是大规模净生态系统二氧化碳交换(NEE)估计的重要方法,但现有的ML升级方法面临一些挑战,特别是在捕获可能与滞后效应相关的NEE年际变化(IAVs)方面。长短期记忆(LSTM)网络具有表征时间记忆效应的能力,有望帮助解决这个问题。在这里,我们利用北美82个站点的通量塔数据,探索了LSTM在预测不同生态系统新能源经济性方面的潜力。具有不同植物功能类型(PFTs)的LSTM模型能够解释测试集中NEE月变化的79.19% (R2 = 0.79), RMSE和MAE分别为0.89和0.57 g C m-2 d-1 (r = 0.89, p <0.001)。此外,LSTM模型在预测跨站点变异性方面表现稳健,67.19%的LSTM模型在有和没有区分PFTs的情况下都能预测站点,预测能力有所提高。最重要的是,预测NEE的IAV与通量观测值高度相关(r = 0.81, p <0.001),明显优于随机森林模型(r = -0.21, p = 0.011)。在所有9个pft中,太阳诱导的叶绿素荧光、向下短波辐射和叶面积指数是解释NEE变化的最重要变量,合计约占54.01%。本研究强调了LSTM在利用多源遥感数据改善碳通量升级方面的巨大潜力。
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引用次数: 0
Hydrological Response to Land Use Land Cover and Climate Variability, and Simulation of Sediment Export and Water Yield in the Catchment Kotri Sindh Pakistan Using SWAT Model 基于SWAT模型的巴基斯坦信德省Kotri流域土地利用、土地覆盖和气候变率的水文响应及产沙量模拟
Pub Date : 2023-11-14 DOI: 10.22541/au.169999221.18673873/v1
Rabia Chhachhar, Dr.Habibullah Abbasi
The water availability concerns have been increasing due to having significant impacts of Land use land cover change and climate variability. In terms of developing countries, it is one of the biggest challenges to overcome and manage sustainability in the present and future. This study aims to evaluate the change in hydrological components and simulation of sediment yield and water yield on the large-scale basin of Kotri barrage with a change in streamflow due to a change in LULC. This study has been done on the watershed as well as the sub-watershed level to have an accurate estimation and simulation by finding the response of hydrological components towards its natural and human-induced factors using the Soil and Water Assessment tool (SWAT) with high-resolution geospatial and temporal inputs over the Kotri catchment. The sediment and water yield were quantified using 42 years of simulation (1990-2022) on the sub-basin level, projected to LuLc 1990, 2000, 2010, and 2022. The increase in deforestation, agriculture, and settlement areas resulted increase in sediment load in the catchment. The sub-basins 14, 11, 12, and 13, with a high elevation and slope and with less vegetation showed higher sediment load and water yield than the sub-basins with gentle slope and with high natural vegetation cover. The sub-basins 10, 4, and 1 showed high water yield availability compared to basins 2,3,5,6,7,8,9. This may be the result of vegetation differences. However, contained less sediment load than basins 14, 11, 12, and 13. The main objective was to quantify the significant changes affecting catchment and sub-catchment areas, to have a better understanding of the management plan regarding LULC. The simulated data was further projected to prediction using machine algorithms (ARIMA) model for precipitation prediction, and (SARIMAX) model to predict the sediment yield and water yield in the catchment to 2060.
由于土地利用、土地覆盖变化和气候变率的显著影响,对水资源的关注日益增加。就发展中国家而言,这是目前和未来需要克服和管理可持续性的最大挑战之一。本研究旨在评估Kotri拦河坝大尺度流域因LULC变化导致流量变化的水文成分变化及产沙产水量模拟。本研究利用高分辨率地理空间和时间输入的土壤和水评估工具(SWAT),在Kotri流域和子流域水平上进行了准确的估算和模拟,通过寻找水文成分对其自然和人为因素的响应。利用42年模拟(1990-2022年)对子流域的产沙量和产水量进行了量化,预测了1990年、2000年、2010年和2022年的土地利用潜力。森林砍伐、农业和定居地区的增加导致了流域泥沙负荷的增加。高海拔、高坡度、植被较少的14、11、12、13子流域的输沙量和产水量均高于坡度平缓、自然植被覆盖度高的子流域。与流域2、3、5、6、7、8、9相比,子流域10、4、1表现出较高的产水量有效性。这可能是植被差异的结果。但含沙量小于流域14、11、12和13。主要目的是量化影响集水区和次集水区的重大变化,以便更好地了解有关土地利用资源的管理计划。利用机器算法(ARIMA)模型进行降水预测,利用SARIMAX模型预测流域至2060年的产沙量和产水量。
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