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Intravenous versus oral iron for anaemia among pregnant women in Nigeria (IVON): an open-label, randomised controlled trial. 静脉注射与口服铁剂治疗尼日利亚孕妇贫血(IVON):开放标签随机对照试验。
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-10-01 DOI: 10.1016/s2214-109x(24)00239-0
Bosede B Afolabi,Ochuwa A Babah,Titilope A Adeyemo,Mobolanle Balogun,Aduragbemi Banke-Thomas,Ajibola I Abioye,Opeyemi R Akinajo,Hadiza S Galadanci,Rachel A Quao,Hameed Adelabu,Nadia A Sam-Agudu,Victoria O Adaramoye,Abdulazeez Abubakar,Bolanle Banigbe,Gbenga Olorunfemi,Lenka Beňová,Elin C Larsson,Kristi S Annerstedt,Claudia Hanson,Jim Thornton,
BACKGROUNDOral iron for anaemia in pregnancy is often not well tolerated, with poor adherence. Iron administered intravenously might address these tolerance and adherence issues. We investigated the effectiveness and safety of intravenous ferric carboxymaltose versus oral ferrous sulphate on anaemia and iron deficiency among pregnant women in Nigeria.METHODSWe did a multicentre, open-label, parallel, randomised controlled trial of pregnant women (aged 15-49 years) with haemoglobin (Hb) concentrations of less than 10 g/dL at 20-32 weeks' gestation from 11 primary, secondary, or tertiary health facilities in Nigeria (five in Lagos and six in Kano). Exclusion criteria included vaginal bleeding, blood transfusion or major surgery within the past 3 months, symptomatic anaemia, anaemia known to be unrelated to iron deficiency, clinically confirmed malabsorption syndrome, previous hypersensitivity to any form of iron, pre-existing maternal depression or other major psychiatric illness, immune-related diseases, such as systemic lupus erythematosus or rheumatoid arthritis, or severe allergic reactions. Participants were randomly assigned (1:1) by nurses and doctors using a web-based randomisation service to either receive a single dose of intravenous ferric carboxymaltose (20 mg/kg to a maximum of 1000 mg) or oral ferrous sulphate (200 mg; 65 mg elemental iron) three times daily until 6 weeks postpartum. The study was primarily unmasked. Primary outcomes were maternal anaemia (Hb <11 g/dL) at 36 weeks' gestation and preterm birth at before 37 weeks' gestation, with analysis by intention to treat in participants with available data. This study was registered at the ISRCTN registry on Dec 10, 2020 (ISRCTN63484804) and on ClinicalTrials.gov (NCT04976179) on April 7, 2021.FINDINGSBetween Aug 10, 2021, and Dec 15, 2022, 13 724 pregnant women were screened for eligibility. 12 668 were excluded due to ineligibility for inclusion, and 1056 provided consent to participate and were randomly assigned to either the intravenous or oral administration groups. 527 were assigned to the intravenous ferric carboxymaltose group and 529 were assigned to the oral ferrous sulphate group. 518 in the intravenous group were assessed at 36 weeks' gestational age and after 518 deliveries, and 511 completed the 6 weeks postpartum visit. 513 in the oral ferrous sulphate group were assessed at 36 weeks' gestational age and after 512 deliveries, and 501 completed the 6 weeks postpartum visit. No significant difference was found in anaemia at 36 weeks (299 [58%] of 517 in the intravenous group vs 305 [61%] of 503 in the oral group; risk ratio 0·95, 95% CI 0·85-1·06; p=0·36), nor in preterm birth (73 [14%] of 518 vs 77 [15%] of 513; 0·94, 0·70-1·26; p=0·66). There were no significant differences in adverse events. The most common adverse events were diarrhoea (in six participants) and vomiting (in three participants) in the oral group and fatigue (in two participants) and headache (in tw
背景:口服铁剂治疗妊娠期贫血的耐受性往往不佳,而且依从性也很差。静脉注射铁剂可以解决这些耐受性和依从性问题。我们调查了静脉注射羧甲基亚铁与口服硫酸亚铁对尼日利亚孕妇贫血和缺铁的有效性和安全性。方法 我们对尼日利亚 11 家一级、二级或三级医疗机构(5 家在拉各斯,6 家在卡诺)中妊娠 20-32 周、血红蛋白(Hb)浓度低于 10 g/dL 的孕妇(年龄在 15-49 岁之间)进行了多中心、开放标签、平行随机对照试验。排除标准包括阴道出血、过去 3 个月内输血或接受过大手术、无症状性贫血、已知与缺铁无关的贫血、临床证实的吸收不良综合征、既往对任何形式的铁过敏、既往患有抑郁症或其他重大精神疾病、免疫相关疾病(如系统性红斑狼疮或类风湿性关节炎)或严重过敏反应。参与者由护士和医生通过网络随机分配(1:1),接受单剂量静脉注射羧甲基亚铁(20 毫克/千克,最多 1000 毫克)或口服硫酸亚铁(200 毫克;65 毫克元素铁),每天三次,直至产后 6 周。该研究主要是无掩蔽研究。主要结果为妊娠 36 周时的产妇贫血(Hb <11 g/dL)和妊娠 37 周前的早产,对有数据的参与者进行意向治疗分析。该研究于 2020 年 12 月 10 日在 ISRCTN 注册中心注册(ISRCTN63484804),并于 2021 年 4 月 7 日在 ClinicalTrials.gov 注册(NCT04976179)。结果在 2021 年 8 月 10 日至 2022 年 12 月 15 日期间,共筛选出 13 724 名符合条件的孕妇。12 668 名孕妇因不符合纳入条件而被排除,1056 名孕妇同意参与并被随机分配到静脉注射组或口服组。527 人被分配到静脉注射羧甲基亚铁组,529 人被分配到口服硫酸亚铁组。静脉注射组中有 518 人在妊娠 36 周和 518 次分娩后接受了评估,511 人完成了产后 6 周的访视。口服硫酸亚铁组有 513 人在孕 36 周和 512 次分娩后接受了评估,501 人完成了产后 6 周的访视。36 周时的贫血率(静脉注射组 517 例中的 299 [58%] vs 口服组 503 例中的 305 [61%];风险比 0-95,95% CI 0-85-1-06;p=0-36)和早产率(518 例中的 73 [14%] vs 513 例中的 77 [15%];0-94,0-70-1-26;p=0-66)均无明显差异。不良反应方面没有明显差异。口服组最常见的不良反应是腹泻(6 人)和呕吐(3 人),而静脉注射组最常见的不良反应是疲劳(2 人)和头痛(2 人)。我们建议尼日利亚和类似地区的贫血孕妇考虑静脉注射铁剂。
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引用次数: 0
Enhancing preventive treatment for malaria in pregnancy: insights from a trial on targeted information transfer. 加强妊娠期疟疾的预防性治疗:有针对性的信息传递试验的启示。
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-10-01 DOI: 10.1016/s2214-109x(24)00292-4
Collins Ouma,Nissily Mushani
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引用次数: 0
From reform to excellence: the future of health care in Egypt. 从改革到卓越:埃及医疗保健的未来。
IF 19.9 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-10-01 Epub Date: 2024-07-26 DOI: 10.1016/S2214-109X(24)00310-3
Ahmed El-Sobky, Mazen Aladdin
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引用次数: 0
Intravenous ferric carboxymaltose for iron deficiency anaemia in pregnancy. 静脉注射羧甲基铁治疗妊娠期缺铁性贫血。
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-10-01 DOI: 10.1016/s2214-109x(24)00331-0
Uchenna I Nwagha,Theresa U Nwagha
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引用次数: 0
Maternal intimate partner violence and child health outcomes. 孕产妇亲密伴侣暴力与儿童健康结果。
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-24 DOI: 10.1016/s2214-109x(24)00358-9
Rachel Jewkes,Mercilene Machisa
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引用次数: 0
Intimate partner violence and childhood health outcomes in 37 sub-Saharan African countries: an analysis of demographic health survey data from 2011 to 2022. 37 个撒哈拉以南非洲国家的亲密伴侣暴力与儿童健康结果:2011 年至 2022 年人口健康调查数据分析。
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-24 DOI: 10.1016/s2214-109x(24)00313-9
Abel F Dadi,Kedir Y Ahmed,Yemane Berhane,Habtamu Mellie Bizuayehu,Getayeneh Antehunegn Tesema,Tahir A Hassen,Getiye Dejenu Kibret,Daniel Bekele Ketema,Meless G Bore,Sewunet Admasu Belachew,Erkihun Amsalu,Sergio Nhassengo,Desalegn Markos Shifti,Abdulbasit Seid,Yonatan M Mesfin,Teketo Kassaw Tegegne,Daniel Bogale Odo,Zemenu Yohannes Kassa,Subash Thapa,Eshetu Girma Kidane,Hanna Demelash Desyibelew,Awoke Misganaw,Berihun M Zeleke,Obasanjo Afolabi Bolarinwa,Allen G Ross
BACKGROUNDUnderstanding the contribution of intimate partner violence (IPV) to childhood health outcomes (eg, morbidity and mortality) is crucial for improving child survival in sub-Saharan Africa. This comprehensive study aimed to explore the associations between maternal exposure to physical, sexual, or emotional violence and adverse childhood health outcomes in sub-Saharan Africa.METHODSWe analysed Demographic Health Survey datasets from 37 sub-Saharan African countries from 2011 to 2022. A generalised linear mixed model was used to examine the associations between maternal physical violence, sexual violence, or emotional violence, and early childhood health outcomes (eg, acute respiratory infection, diarrhoea, undernutrition, and child mortality). A random effects meta-analysis was used to calculate pooled odds ratios (ORs) for adverse childhood health outcomes. The odds of undernutrition and mortality were 55% and 58% higher among children younger than 5 years born to mothers who were exposed to physical and sexual violence, respectively.FINDINGS238 060 children younger than 5 years were included. Children whose mothers experienced physical violence (adjusted OR 1·33, 95% CI 1·29-1·42), sexual violence (1·47, 1·34-1·62), emotional violence (1·39, 1·32-1·47), or a combination of emotional and sexual violence (1·64, 1·20-2·22), or a combination of all the three forms of violence (1·88, 1·62-2·18) were associated with an increased odds of developing diarrhoeal disease. Similarly, children whose mothers experienced physical violence (1·43, 1·28-1·59), sexual violence (1·47, 1·34-1·62), emotional violence (1·39, 1·32-1·47), or a combination of emotional and sexual violence (1·48, 1·16-1·89), or a combination of all three forms of violence (1·66, 1·47-1·88) were positively associated with symptoms of acute respiratory infection.INTERPRETATIONWe found a strong link between maternal exposure to IPV and health outcomes for children younger than 5 years in sub-Saharan Africa, with minor variations across countries. To address childhood morbidity and mortality attributed to IPV, interventions need to be tailored for specific countries. Burkina Faso, Burundi, Chad, Comoros, Gabon, Liberia, Nigeria, Sierra Leone, South Africa, and Uganda should be priority nations.FUNDINGNone.
背景了解亲密伴侣暴力(IPV)对儿童健康结果(如发病率和死亡率)的影响对于提高撒哈拉以南非洲地区儿童的存活率至关重要。这项综合研究旨在探讨撒哈拉以南非洲地区孕产妇遭受身体暴力、性暴力或情感暴力与不良儿童健康后果之间的关联。方法 我们分析了 2011 年至 2022 年撒哈拉以南非洲 37 个国家的人口健康调查数据集。我们采用广义线性混合模型研究了孕产妇身体暴力、性暴力或情感暴力与儿童早期健康结果(如急性呼吸道感染、腹泻、营养不良和儿童死亡率)之间的关联。随机效应荟萃分析用于计算不良儿童健康结果的集合几率比(ORs)。在遭受过身体暴力和性暴力的母亲所生的 5 岁以下儿童中,营养不良和死亡的几率分别高出 55% 和 58%。母亲遭受过身体暴力(调整后 OR 1-33,95% CI 1-29-1-42)、性暴力(1-47,1-34-1-62)、情感暴力(1-39,1-32-1-47)、情感暴力和性暴力组合(1-64,1-20-2-22)或三种暴力组合(1-88,1-62-2-18)的儿童患腹泻病的几率增加。同样,母亲遭受过身体暴力(1-43,1-28-1-59)、性暴力(1-47,1-34-1-62)、情感暴力(1-39,1-32-1-47)或情感暴力和性暴力组合(1-48,1-16-1-89)或三种暴力组合(1-66,1-47-1-88)的儿童与急性呼吸道感染症状呈正相关。解释我们发现,在撒哈拉以南非洲地区,孕产妇遭受 IPV 与 5 岁以下儿童的健康结果之间存在密切联系,但各国之间略有不同。要解决 IPV 导致的儿童发病率和死亡率问题,需要针对具体国家的情况采取相应的干预措施。布基纳法索、布隆迪、乍得、科摩罗、加蓬、利比里亚、尼日利亚、塞拉利昂、南非和乌干达应成为优先国家。
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引用次数: 0
Safeguarding the SDG promise to end hunger and leave no one behind: the plight of children in the Gaza Strip. 维护可持续发展目标中消除饥饿和不让一个人掉队的承诺:加沙地带儿童的困境。
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-23 DOI: 10.1016/s2214-109x(24)00367-x
Lara Nasreddine,Lamis Jomaa
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引用次数: 0
Food insecurity, dietary inadequacy, and malnutrition in the Gaza Strip: a cross-sectional nutritional assessment of refugee children entering the first grade of UNRWA schools and their households before the conflict of 2023-24. 加沙地带的粮食不安全、膳食不足和营养不良:对 2023-24 年冲突前进入近东救济工程处学校一年级的难民儿童及其家庭进行的横断面营养评估。
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-23 DOI: 10.1016/s2214-109x(24)00320-6
Masako Horino,Randa Zaqqout,Rami Habash,Shatha Albaik,Yehia Abed,Ghada Al-Jadba,Keith P West,Akihiro Seita
BACKGROUNDGaza has long been subjected to food insecurity; however, little was known about the influence of food insecurity on the nutritional wellbeing of schoolchildren. To fill this gap, the UN Relief and Works Agency for Palestine Refugees in the Near East (UNRWA), which provides humanitarian relief to Palestine refugees, assessed the nutritional status, diet, and food security of refugee children about to enter first grade (aged 4-10 years, mean age 72·1 months) in mid-2023 during a required health examination.METHODSAs part of an annual School Entrance Health Examinations that began in May, a cross-sectional food security and nutritional assessment was added from July 8, to Sept 7, 2023, during which children being examined at six study-designated UNRWA clinics across Gaza were systematically sampled (in a 1:4 ratio) and parental or guardian consent sought for their participation. Household food security was assessed by a seven-point Arab Family food Security Scale score, and respondents were asked about family receipt of food assistance. The 1-week meal patterns of the children were probed, and intake frequencies of 49 foods in the past month categorised into ten nutritious food groups to assess diet diversity. The weight, height, and haemoglobin concentrations (assessed with a photometric analyser) of the children were measured. The UNRWA Research Review Board approved all study procedures.FINDINGSApproximately 34 000 children underwent the annual School Entrance Health Examination in Gaza in May, 2023 and approximately 16 000 children were estimated to have completed the additional food security and nutritional assessments from July 8, to early Sept 7, 2023, of whom 3814 were systematically sampled at six UNRWA clinics across Gaza, with 3229 (84·7%) parents or guardians consenting for their children to participate. 3155 were interviewed about household food security with a seven-point Arab Family Food Security Score, and 3212 were asked about food assistance receipt. 2694 (83·9%) of 3212 households were on food assistance, 787 (24·9%) of 3155 were classified as food secure (0-2 points), 1025 (32·5%) were classified as moderately (3-5 points) food insecure, and 1343 (42·6%) as severely food insecure (6-7 points). 219 (28·5%) of 768 children reported missing breakfast and 213 (28·4%) of 750 reported missing dinner in the food-secure group, 438 (47·2%) of 928 reported missing breakfast and 426 (45·6%) of 934 reported missing dinner in the moderately food-insecure group, and 956 (75·5%) of 1267 reported missing breakfast and 951 (74·8%) of 1272 reported missing dinner in the severely food-insecure group. Lunch was missed daily by 30 (3·8%) of 786 children in the food-secure group, 54 (5·3%) of 1023 in the moderately food-insecure group, and 193 (14·5%) of 1334 in the severely food-insecure group. Diets were poor in dairy items, meat, poultry, fish, pulses, eggs, and vitamin A-rich vegetables and fruit, and 2225 (68·9%) of 3229 children did n
背景加沙长期以来一直存在粮食不安全问题,但人们对粮食不安全对学龄儿童营养状况的影响知之甚少。为了填补这一空白,为巴勒斯坦难民提供人道主义救济的联合国近东巴勒斯坦难民救济和工程处(UNRWA)在2023年年中对即将上一年级的难民儿童(4-10岁,平均年龄72-1个月)进行了一次必要的健康检查,评估了他们的营养状况、饮食和食品安全。方法作为5月份开始的年度入学健康检查的一部分,在2023年7月8日至9月7日期间增加了一项横断面食品安全和营养评估,在此期间系统地抽取了在加沙地带联合国近东巴勒斯坦难民救济和工程处指定的六家研究诊所接受检查的儿童(按1:4的比例),并征得了他们父母或监护人的同意。家庭食品安全通过阿拉伯家庭食品安全七分量表进行评估,并询问受访者家庭接受食品援助的情况。调查了儿童一周的进餐模式,并将过去一个月中 49 种食物的摄入频率分为 10 个营养食物类别,以评估饮食多样性。还测量了儿童的体重、身高和血红蛋白浓度(用光度分析仪评估)。联合国近东巴勒斯坦难民救济和工程处研究审查委员会批准了所有研究程序。研究结果2023年5月,加沙约有34000名儿童接受了一年一度的入学健康检查,2023年7月8日至9月7日期间,估计约有16000名儿童完成了额外的食品安全和营养评估,其中3814名儿童在加沙的六家联合国近东巴勒斯坦难民救济和工程处诊所接受了系统抽样,3229名(84-7%)家长或监护人同意其子女参与。对 3155 人进行了关于家庭粮食安全的访谈,采用的是阿拉伯家庭粮食安全七分制,对 3212 人进行了关于接受粮食援助情况的询问。3212 个家庭中有 2694 个(83-9%)接受过粮食援助,3155 个家庭中有 787 个(24-9%)被归类为粮食安全(0-2 分),1025 个(32-5%)被归类为中度(3-5 分)粮食不安全,1343 个(42-6%)被归类为严重粮食不安全(6-7 分)。在食物无保障组中,768 名儿童中有 219 人(28-5%)错过了早餐,750 名儿童中有 213 人(28-4%)错过了晚餐;在食物中度无保障组中,928 名儿童中有 438 人(47-2%)错过了早餐,934 名儿童中有 426 人(45-6%)错过了晚餐;在食物严重无保障组中,1267 名儿童中有 956 人(75-5%)错过了早餐,1272 名儿童中有 951 人(74-8%)错过了晚餐。在食物无保障组的 786 名儿童中,有 30 人(3-8%)每天错过午餐;在食物中度无保障组的 1023 名儿童中,有 54 人(5-3%)每天错过午餐;在食物严重无保障组的 1334 名儿童中,有 193 人(14-5%)每天错过午餐。膳食中奶制品、肉类、家禽、鱼类、豆类、蛋类以及富含维生素 A 的蔬菜和水果的含量较低,3229 名儿童中有 2225 人(68-9%)每天的膳食没有达到最低限度的多样化(≥5 种营养食品)。2913名儿童中有72名(2-5%)发育迟缓,129名(4-4%)消瘦(Z值小于-2),3229名儿童中有963名(29-8%)贫血(血红蛋白小于11-5克/分升)。男孩和女孩在饮食、人体测量 Z 值和贫血患病率方面相似。释义有即将上一年级儿童的加沙家庭粮食不安全,依赖粮食援助,这可能会保护儿童的人体测量状况,但他们的饮食缺乏多样性。
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引用次数: 0
How should mpox vaccines be used in DRC and its neighbouring countries? 刚果(金)及其邻国应如何使用麻风腮疫苗?
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-23 DOI: 10.1016/s2214-109x(24)00417-0
Misaki Wayengera
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引用次数: 0
C-reactive protein testing in primary care for acute respiratory infections: a cost-effective strategy to mitigate antimicrobial resistance across different income settings. 急性呼吸道感染初级保健中的 C 反应蛋白检测:在不同收入环境中减少抗菌素耐药性的成本效益战略。
IF 34.3 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-18 DOI: 10.1016/s2214-109x(24)00382-6
Yoel Lubell,Nga Thi Thuy Do,Sonia Lewycka,Augustine Onwunduba,Rogier van Doorn,Heiman Wertheim
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引用次数: 0
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Lancet Global Health
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