Pub Date : 2025-11-12DOI: 10.1016/s2214-109x(25)00403-6
Noa E M Kolpa, Roel Kamerling, Sreeparna Chattopadhyay, Emmanuel Ojo, Mulatu Biru, Igna Bonfrer, Bregje de Kok, Godelieve van Heteren, Kitty W M Bloemenkamp, Beatrijs Stikkers-Muller, Degu Jerene, Ajay Bailey, Koiwah Koi-Larbi, Tessa Roseboom, Wieger Voskuijl, Isabelle L Lange, Veronique Filippi, Indah K Murni, Titus K Beyuo, Manouk A W van de Klundert, Saba Hinrichs-Krapels, Joyce L Browne
{"title":"How funders can shape epistemically just practices in grantmaking: an implementation science-oriented call","authors":"Noa E M Kolpa, Roel Kamerling, Sreeparna Chattopadhyay, Emmanuel Ojo, Mulatu Biru, Igna Bonfrer, Bregje de Kok, Godelieve van Heteren, Kitty W M Bloemenkamp, Beatrijs Stikkers-Muller, Degu Jerene, Ajay Bailey, Koiwah Koi-Larbi, Tessa Roseboom, Wieger Voskuijl, Isabelle L Lange, Veronique Filippi, Indah K Murni, Titus K Beyuo, Manouk A W van de Klundert, Saba Hinrichs-Krapels, Joyce L Browne","doi":"10.1016/s2214-109x(25)00403-6","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00403-6","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"159 1","pages":""},"PeriodicalIF":34.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/s2214-109x(25)00395-x
Hanna-Tina Fischer, Johanna Hanefeld, Augustina Koduah
{"title":"Implementation science and power: equity-oriented implementation science needs a power lens","authors":"Hanna-Tina Fischer, Johanna Hanefeld, Augustina Koduah","doi":"10.1016/s2214-109x(25)00395-x","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00395-x","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"5 1","pages":""},"PeriodicalIF":34.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/s2214-109x(25)00374-2
Catia Cillóniz, Markus Fally, Scott Evans, Guinevere Dy-Agra
{"title":"The pneumonia challenge: time to end the global neglect","authors":"Catia Cillóniz, Markus Fally, Scott Evans, Guinevere Dy-Agra","doi":"10.1016/s2214-109x(25)00374-2","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00374-2","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"15 1","pages":""},"PeriodicalIF":34.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1016/s2214-109x(25)00370-5
Golnaz Rezaeizadeh, Hossein Poustchi, Maryam Sharafkhah, Seyede Shahrbanoo Daniali, Navid Danaei, Amir Houshang Mehrparvar, Mohammad Javad Zare Sakhvidi, Hamid Hakimi, Zahra Mohammadi, Mohammad Ali Mansournia, Roya Kelishadi
{"title":"Growth patterns in preterm infants in Iran (the PERSIAN Birth Cohort): a prospective birth cohort study","authors":"Golnaz Rezaeizadeh, Hossein Poustchi, Maryam Sharafkhah, Seyede Shahrbanoo Daniali, Navid Danaei, Amir Houshang Mehrparvar, Mohammad Javad Zare Sakhvidi, Hamid Hakimi, Zahra Mohammadi, Mohammad Ali Mansournia, Roya Kelishadi","doi":"10.1016/s2214-109x(25)00370-5","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00370-5","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"13 1","pages":""},"PeriodicalIF":34.3,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145485481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-08DOI: 10.1016/s2214-109x(25)00415-2
Latif Ndeketa, Valérie Haine, Muriel Debois, Kwaku Poku Asante, Prince Darko Agyapong, Seyram Kaali, Raghavendra Devadiga, Samuel B E Harrison, Owusu Boahen, Neil French, Kingsley Kayan, Bernhards Ogutu, Elisha Adeniji, Simon Kariuki, Seth Owusu-Agyei, Fredrick Olewe, Tikhala Makhaza Jere, Kenneth Maleta, Donnie Mategula, Phylis Mzanga, Vincent Katunga Phiri, Patrick Odum Ansah, John Orimbo, Nana Akosua Ansah, Mattea Orsini, John Michael Ong'echa, Abraham Rexford Oduro, Peter M Sifuna, Daniel K Azongo, Walter Otieno, Oscar Bangre, Michael Bandasua Kaburise, Lucy Osei Ababio, Janet Nyawira Oyieko, Valentine Sing'oei, Stellah Kevyne Amoit, Wongani Nyangulu, Lode Schuerman, Denis Awuni, Benard Omondi Ochieng, Irene Onyango, Patricia Odera-Ojwang, Esther Achieng Oguk, Yolanda Guerra Mendoza, Reuben Yego Cherop, George Odhiambo Okoth, Cristina Cravcenco, Raphael Chipatala, François Roman, Martina Oneko, Miloje Savic, Oscar Agyei, Joseph Ayimbila Ana-Aro, Seth Arthur, Cynthia Aton, Yvonne Afrah Berko, Dennis Bii, Miriam Chomba, David Dosoo, Clifford Kwarteng Kyeremateng, Jane Masinde, Paul Njika, James Nyagechanga, Angelina Odila, Daniel Omollo, Samuel Osei-Owusu, Sarah Otieno, Kephas Otieno, Daniel Ouko, Ronald Owino, Emmanuel Yirenkyi
{"title":"Effectiveness of the RTS,S/AS01E malaria vaccine in a real-world setting over 1 year of follow-up after the three-dose primary schedule: an interim analysis of a phase 4 study in Ghana, Kenya, and Malawi","authors":"Latif Ndeketa, Valérie Haine, Muriel Debois, Kwaku Poku Asante, Prince Darko Agyapong, Seyram Kaali, Raghavendra Devadiga, Samuel B E Harrison, Owusu Boahen, Neil French, Kingsley Kayan, Bernhards Ogutu, Elisha Adeniji, Simon Kariuki, Seth Owusu-Agyei, Fredrick Olewe, Tikhala Makhaza Jere, Kenneth Maleta, Donnie Mategula, Phylis Mzanga, Vincent Katunga Phiri, Patrick Odum Ansah, John Orimbo, Nana Akosua Ansah, Mattea Orsini, John Michael Ong'echa, Abraham Rexford Oduro, Peter M Sifuna, Daniel K Azongo, Walter Otieno, Oscar Bangre, Michael Bandasua Kaburise, Lucy Osei Ababio, Janet Nyawira Oyieko, Valentine Sing'oei, Stellah Kevyne Amoit, Wongani Nyangulu, Lode Schuerman, Denis Awuni, Benard Omondi Ochieng, Irene Onyango, Patricia Odera-Ojwang, Esther Achieng Oguk, Yolanda Guerra Mendoza, Reuben Yego Cherop, George Odhiambo Okoth, Cristina Cravcenco, Raphael Chipatala, François Roman, Martina Oneko, Miloje Savic, Oscar Agyei, Joseph Ayimbila Ana-Aro, Seth Arthur, Cynthia Aton, Yvonne Afrah Berko, Dennis Bii, Miriam Chomba, David Dosoo, Clifford Kwarteng Kyeremateng, Jane Masinde, Paul Njika, James Nyagechanga, Angelina Odila, Daniel Omollo, Samuel Osei-Owusu, Sarah Otieno, Kephas Otieno, Daniel Ouko, Ronald Owino, Emmanuel Yirenkyi","doi":"10.1016/s2214-109x(25)00415-2","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00415-2","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"9 1","pages":""},"PeriodicalIF":34.3,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145461345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of maternity care improvement, fertility decline, and contraceptive use on global maternal mortality reduction between 2000 and 2023: results from a decomposition analysis","authors":"Saifuddin Ahmed, Moazzam Ali, Iqbal Shah, Amy Tsui","doi":"10.1016/s2214-109x(25)00409-7","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00409-7","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"166 1","pages":""},"PeriodicalIF":34.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145441939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-05DOI: 10.1016/s2214-109x(25)00379-1
Farina L Shaaban, Rosalie W Groenendijk, Ranju Baral, Mauricio T Caballero, James E Crowe, Janet A Englund, Ignacio Esteban, Siddhivinayak Hirve, Mark Jit, Alexis M Kalergis, Ruth A Karron, Nicholas Lukacs, Federico Martinon-Torres, Asuncion Mejias, Harish Nair, M Imran Nisar, Joyce U Nyiro, Clint Pecenka, Erin Sparrow, Padmini Srikantiah, Ryan S Thwaites, Heather J Zar, Louis J Bont
{"title":"The path to equitable respiratory syncytial virus prevention for infants: challenges and opportunities for global implementation","authors":"Farina L Shaaban, Rosalie W Groenendijk, Ranju Baral, Mauricio T Caballero, James E Crowe, Janet A Englund, Ignacio Esteban, Siddhivinayak Hirve, Mark Jit, Alexis M Kalergis, Ruth A Karron, Nicholas Lukacs, Federico Martinon-Torres, Asuncion Mejias, Harish Nair, M Imran Nisar, Joyce U Nyiro, Clint Pecenka, Erin Sparrow, Padmini Srikantiah, Ryan S Thwaites, Heather J Zar, Louis J Bont","doi":"10.1016/s2214-109x(25)00379-1","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00379-1","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"69 1","pages":""},"PeriodicalIF":34.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145442090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/s2214-109x(25)00317-1
Sabine Lichtenegger,Isabel Klugherz,Gabriel E Wagner,Justine Michel,Bastien Mollo,Adama Sanogo,Moussa K Diawara,Soumaila Traore,Hyacinthe G Kodo,Max-Yvon Mbangui,Marie-Hortense Koudika,Youssouf Diam Sidibé,Johanna Dabernig-Heinz,Christian Kohler,Karsten Becker,Karoline Assig,Direk Limmathurotsakul,Matthias Kohl,Carolina Jimenez,Rupa Kanapathipillai,Janet Ousley,Ivo Steinmetz
BACKGROUNDMelioidosis is a neglected tropical bacterial infection with a high mortality rate caused by the Gram-negative soil bacterium Burkholderia pseudomallei. Although the disease is increasingly recognised in Asian and Pacific regions, the situation in Africa is characterised by a scarcity of data and great uncertainty regarding the disease burden and distribution. Here, we aimed to report cases of melioidosis in children younger than 5 years in Mali, where no confirmed melioidosis had been reported previously.METHODSMédecins Sans Frontières maintains a paediatrics programme in Koutiala, Mali, for children younger than 5 years, including a microbiology laboratory. Between January 2018, and September 2021, biochemical characteristics of bacterial isolates suggested the presence of B pseudomallei in clinical samples from children admitted with severe signs of infection. Isolated strains were characterised by whole genome sequencing. Clinical data on the course and outcome of confirmed melioidosis cases were retrospectively analysed from the hospital records.FINDINGS31 melioidosis cases of children younger than 5 years were confirmed. 15 (48%) cases were in infants aged 12 months or younger. B pseudomallei-positive samples included 28 blood cultures, two pleural fluids, and one pus sample. Of 19 patients with available outcome data, 12 (63%) died. Phylogenetic analysis of the B pseudomallei isolates revealed high genetic diversity suggesting long-standing persistence of the bacterium in this region. We estimated an annual melioidosis incidence of 8·8 per 100 000 (95% CI 5·7-11·9) in the paediatric population and the derived 15·5 per 100 000 (10·0-20·8) for the overall population.INTERPRETATIONThis is, to the best of our knowledge, the first case series reported in Mali and the largest cohort of melioidosis cases ever reported in Africa. Our annual incidence estimates suggest that melioidosis is a significant public health problem in this part of Africa. These findings clearly highlight the need for improved diagnostics and observational studies to learn more about the African melioidosis burden. They also support the inclusion of melioidosis in national health strategies to inform surveillance and empiric treatment protocols. As melioidosis is resistant to common empirical antibiotic regimens, these measures are essential to reduce the high mortality rate.FUNDINGNone.TRANSLATIONFor the French translation of the abstract see Supplementary Materials section.
{"title":"Melioidosis in Mali: a retrospective observational study.","authors":"Sabine Lichtenegger,Isabel Klugherz,Gabriel E Wagner,Justine Michel,Bastien Mollo,Adama Sanogo,Moussa K Diawara,Soumaila Traore,Hyacinthe G Kodo,Max-Yvon Mbangui,Marie-Hortense Koudika,Youssouf Diam Sidibé,Johanna Dabernig-Heinz,Christian Kohler,Karsten Becker,Karoline Assig,Direk Limmathurotsakul,Matthias Kohl,Carolina Jimenez,Rupa Kanapathipillai,Janet Ousley,Ivo Steinmetz","doi":"10.1016/s2214-109x(25)00317-1","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00317-1","url":null,"abstract":"BACKGROUNDMelioidosis is a neglected tropical bacterial infection with a high mortality rate caused by the Gram-negative soil bacterium Burkholderia pseudomallei. Although the disease is increasingly recognised in Asian and Pacific regions, the situation in Africa is characterised by a scarcity of data and great uncertainty regarding the disease burden and distribution. Here, we aimed to report cases of melioidosis in children younger than 5 years in Mali, where no confirmed melioidosis had been reported previously.METHODSMédecins Sans Frontières maintains a paediatrics programme in Koutiala, Mali, for children younger than 5 years, including a microbiology laboratory. Between January 2018, and September 2021, biochemical characteristics of bacterial isolates suggested the presence of B pseudomallei in clinical samples from children admitted with severe signs of infection. Isolated strains were characterised by whole genome sequencing. Clinical data on the course and outcome of confirmed melioidosis cases were retrospectively analysed from the hospital records.FINDINGS31 melioidosis cases of children younger than 5 years were confirmed. 15 (48%) cases were in infants aged 12 months or younger. B pseudomallei-positive samples included 28 blood cultures, two pleural fluids, and one pus sample. Of 19 patients with available outcome data, 12 (63%) died. Phylogenetic analysis of the B pseudomallei isolates revealed high genetic diversity suggesting long-standing persistence of the bacterium in this region. We estimated an annual melioidosis incidence of 8·8 per 100 000 (95% CI 5·7-11·9) in the paediatric population and the derived 15·5 per 100 000 (10·0-20·8) for the overall population.INTERPRETATIONThis is, to the best of our knowledge, the first case series reported in Mali and the largest cohort of melioidosis cases ever reported in Africa. Our annual incidence estimates suggest that melioidosis is a significant public health problem in this part of Africa. These findings clearly highlight the need for improved diagnostics and observational studies to learn more about the African melioidosis burden. They also support the inclusion of melioidosis in national health strategies to inform surveillance and empiric treatment protocols. As melioidosis is resistant to common empirical antibiotic regimens, these measures are essential to reduce the high mortality rate.FUNDINGNone.TRANSLATIONFor the French translation of the abstract see Supplementary Materials section.","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"45 1","pages":"e1964-e1972"},"PeriodicalIF":34.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/s2214-109x(25)00357-2
Rajeev Gupta,Indu Mohan
{"title":"NCD risk factors in low-income populations in India.","authors":"Rajeev Gupta,Indu Mohan","doi":"10.1016/s2214-109x(25)00357-2","DOIUrl":"https://doi.org/10.1016/s2214-109x(25)00357-2","url":null,"abstract":"","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"102 1","pages":"e1792-e1793"},"PeriodicalIF":34.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}