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Contact Angle of Nepenthes alata Slippery Zone: Results from Measurement and Model Analysis 新戊草滑带接触角的测量与模型分析
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-12-15 DOI: 10.1680/jbibn.21.00019
Lixin Wang, Pan Pan, S. Yan, Shiyun Dong
The slippery zone of Nepenthes alata depends on its highly evolved morphology and structure to show remarkable superhydrophobicity, which has gradually become a biomimetic prototype for developing superhydrophobic materials. However, the mechanism governing this phenomenon has not been fully revealed through model analysis. In this paper, the superhydrophobicity of slippery zone is studied by contact angle measurement, morphology/structure examination and model analysis. The slippery zone causes ultrapure water droplet to produce a considerably high contact angle (155.11–158.30°), and has a micro-nano scale hierarchical structures consisting of lunate cells and wax coverings. According to the Cassie-Baxter equation and a self-defined infiltration coefficient, a model was established to analyze the effect of structure characteristic on the contact angle. Analysis result showed that the calculated contact angle (154.67–159.49°) was highly consistent with the measured contact angle, indicating that the established model can quantitatively characterize the relationship between the contact angle and the structure characteristic. Our study provides some evidences to further reveal the superhydrophobic mechanism of Nepenthes alata slippery zone, as well as inspires the biomimetic development of superhydrophobic surfaces.
阿拉塔猪笼草的滑带取决于其高度进化的形态和结构,以显示出显著的超疏水性,这已逐渐成为开发超疏水材料的仿生原型。然而,通过模型分析还没有完全揭示这种现象的机制。本文通过接触角测量、形貌/结构检测和模型分析,研究了滑带的超疏水性。光滑区域导致超纯水滴产生相当高的接触角(155.11–158.30°),并具有由月状细胞和蜡覆盖物组成的微纳米级分级结构。根据Cassie-Baxter方程和一个自定义的渗透系数,建立了一个模型来分析结构特性对接触角的影响。分析结果表明,计算的接触角(154.67–159.49°)与测量的接触角高度一致,表明所建立的模型能够定量表征接触角与结构特征之间的关系。我们的研究为进一步揭示有尾猪笼草滑带的超疏水机制提供了一些证据,并启发了超疏水表面的仿生发展。
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引用次数: 0
A Histopathological Evaluation of Amino Acids-Capped Silver Nanoconjugates (AgNCs) Against Cadmium-Induced Toxicity in Albino Mice 氨基酸封端的银纳米缀合物(AgNCs)对镉诱导的白化小鼠毒性的组织病理学评价
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-12-15 DOI: 10.1680/jbibn.21.00033
S. A. Ditta, A. Yaqub, Fouzia Tanvir, R. Ullah, Muhammad Rashid, Muhammad Bilal
Various molecules may modify the surface chemistry of commonly used nanomaterials (NMs), resulting in the synthesis of novel and safer NMs. The current study was delineated to evaluate the in vivo toxicity profiling of the silver nanoconjugates (AgNCs) conjugated with different amino acids. The L-glycine capped-AgNCs exhibited toxicity and caused tissue damage, while L-cystine and L-tyrosine capped-AgNCs showed protective effects against cadmium-induced toxicity. L-cystine-capped-AgNCs performed well as compared to other amino acids-AgNCs. The level of serum creatinine, ALT, AST, ALP, and blood urea increased (p<0.05) in G2, G3, and G5 in comparison to G1 (control group). While an increase in bilirubin for G2 was statistically non-significant (p>0.05). The ALT and AST elevated (p<0.05) in G4, however, other serological parameters in G4 and G6 didn’t show any noticeable change in their values. Histological analysis showed disturbed and deformed cellular structures in liver and kidney tissues of G2, G3, and G5. However, G4 and G6 samples demonstrated minute changes in comparison to G1. It is concluded that L-cystine and L-tyrosine-capped-AgNCs exhibited protective effects and should be tested further for developing safer nanoconjugates for biomedical uses.
各种分子可以修饰常用纳米材料的表面化学性质,从而合成新的、更安全的纳米材料。本研究旨在评价不同氨基酸偶联银纳米偶联物(agnc)的体内毒性。l -甘氨酸盖顶的agncs表现出毒性并引起组织损伤,而l -胱氨酸和l -酪氨酸盖顶的agncs对镉诱导的毒性表现出保护作用。l -胱氨酸- agnc与其他氨基酸- agnc相比表现良好。血清肌酐、ALT、AST、ALP、尿素升高(p0.05)。G4组ALT、AST升高(p<0.05),而G4、G6组其他血清学参数无明显变化。组织学分析显示G2、G3和G5的肝、肾组织细胞结构紊乱和变形。然而,与G1相比,G4和G6样品表现出微小的变化。综上所述,l -胱氨酸和l -酪氨酸包裹的agnc具有保护作用,应进一步测试以开发更安全的生物医学用途纳米偶联物。
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引用次数: 0
Characterization of the Naked Mole Rat Incisors: Chemical Composition, Microstructure and Mechanical Properties 裸鼹鼠切口的化学成分、微观结构和力学性能表征
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-12-15 DOI: 10.1680/jbibn.21.00004
Hongyan Qi, Guixiong Gao, Huixin Wang, Yunhai Ma, Hubiao Wang, Siyang Wu, Jiangtao Yu, Qinghua Wang
The naked mole rat incisors (NMRI) exhibit excellent mechanical properties, which makes it a good prototype for design and fabrication of bionic mechanical systems and materials. In this work, we characterized the chemical composition, microstructure and mechanical properties of NMRI, and further compared these properties with the laboratory rat incisors (LRI). We found that (1) Enamel and dentin are composed of organic matter, inorganic matter and water. The ratio of Ca/P in NMRI enamel is higher than that of LRI enamel. (2) The dentin has a porous structure. The enamel has a three-dimensional reticular structure, which is more complex, regular and denser than the lamellar structure of LRI enamel. (3) Enamel has anisotropy. Its longitudinal nano-hardness is greater than that of transverse nano-hardness, and both of them are higher than that of LRI enamel. Their nano-hardness and elastic modulus increase with the increment of distance from the enamel-dentin boundary. The nano-hardness of dentin is smaller than that of enamel. The chemical composition and microstructure are considered to be the reasons for the excellent properties of NMRI. The chemical composition and unique microstructure can provide inspiration and guidelines for the design of bionic machinery and materials.
裸鼹鼠切牙(NMRI)具有优异的力学性能,是设计和制造仿生机械系统和材料的良好原型。在这项工作中,我们对NMRI的化学成分、微观结构和力学性能进行了表征,并将这些性能与实验室大鼠切牙(LRI)进行了比较。我们发现(1)牙釉质和牙本质由有机物、无机物和水组成。NMRI釉质中Ca/P比值高于LRI釉质。(2) 牙本质具有多孔结构。釉质具有三维网状结构,比LRI釉质的层状结构更复杂、更规则、更致密。(3) 搪瓷具有各向异性。其纵向纳米硬度大于横向纳米硬度,两者均高于LRI搪瓷。它们的纳米硬度和弹性模量随着离牙釉质-牙本质边界距离的增加而增加。牙本质的纳米硬度小于牙釉质的纳米硬度。化学成分和微观结构被认为是NMRI具有优异性能的原因。其化学成分和独特的微观结构可以为仿生机械和材料的设计提供灵感和指导。
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引用次数: 0
Ultrastructural changes of bovine tooth surfaces under erosion in presence of biomimetic hydroxyapatite 仿生羟基磷灰石侵蚀下牛牙表面超微结构的变化
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-12-15 DOI: 21.00017
Kathia Fabritius-Vilpoux, Joachim Enax, David Mayweg, Frederic Meyer, Michael Herbig, Dierk Raabe, Helge-Otto Fabritius
Enamel and dentin are susceptible to acids from food sources leading to dental erosion, a global problem affecting millions of individuals. Particulate hydroxyapatite (HAP) on the tooth surface can influence the effects of acid attacks. Standardized bovine enamel and dentin samples with artificial saliva are used in an in vitro cyclic demineralization–remineralization protocol to analyze the structural changes experienced by tooth surfaces using high-resolution scanning electron microscopy and to evaluate the potential of a HAP-based oral care gel in the protection of teeth from erosive attacks. The interfaces between HAP particle and enamel HAP crystallites are investigated using focused ion beam preparation and transmission electron microscopy. The results show that erosion with phosphoric acid severely affects enamel crystallites and dentin tubules, while artificial saliva leads to remineralization effects. The HAP-gel forms a microscopic layer on both enamel and dentin surfaces. Upon acid exposure, this layer is sacrificed before the native tooth tissues are affected, leading to significantly lower degrees of demineralization compared to the controls. This demonstrates that the use of particulate HAP as a biomaterial in oral care formulations can help protect enamel and dentin surfaces from erosive attacks during meals using a simple and effective protection principle.
牙釉质和牙本质容易受到食物来源中的酸的影响,从而导致牙齿腐蚀,这是一个影响数百万人的全球性问题。牙齿表面的羟基磷灰石颗粒(HAP)会影响酸侵蚀的效果。标准化的牛牙釉质和牙本质样品与人工唾液在体外循环脱矿-再矿化方案中使用高分辨率扫描电子显微镜来分析牙齿表面经历的结构变化,并评估基于hap的口腔护理凝胶在保护牙齿免受侵蚀攻击方面的潜力。利用聚焦离子束制备和透射电镜研究了HAP粒子与珐琅HAP晶体之间的界面。结果表明,磷酸对牙本质微管和牙釉质微晶的侵蚀作用较为严重,而人工唾液对牙本质微管的再矿化作用较为明显。hap凝胶在牙釉质和牙本质表面形成微观层。在酸暴露后,这一层在原生牙齿组织受到影响之前就被牺牲了,与对照组相比,导致脱矿程度明显降低。这表明,在口腔护理配方中使用颗粒HAP作为生物材料,可以使用简单有效的保护原理帮助保护牙釉质和牙本质表面免受侵蚀。
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引用次数: 0
Fluorophosphate Bio-Glass for Bone Tissue Engineering: In Vitro and In Vivo Study 骨组织工程用氟磷酸盐生物玻璃的体内外研究
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-10-18 DOI: 10.1680/jbibn.21.00025
P. Sankaralingam, Poornimadevi Sakthivel, Priscilla A.s., Abirami Periyasamy, Jenifa Begam Rahumathullah, Vijayakumar Thangavel
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引用次数: 0
Ultrastructural chaNges of Bovine Enamel and Dentin Surfaces Under Chemical Erosion in Presence of Biomimetic Hydroxyapatite Crystallites 仿生羟基磷灰石晶体存在下牛牙釉质和牙本质表面化学侵蚀的超微结构变化
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-10-18 DOI: 10.1680/jbibn.21.00017
Kathia Fabritius-Vilpoux, J. Enax, D. Mayweg, Frederic Meyer, M. Herbig, D. Raabe, H. Fabritius
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引用次数: 8
Bioactivity-guided nanoparticle synthesis from Zingiber officinale and Mentha longifolia 生物活性引导下药用生姜和薄荷纳米颗粒的合成
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-09-02 DOI: 21.00018
Raja Adil Sarfraz, Rizwan Ashraf, Saira Bedi, Iqra Sardar
To date, various reports have exhibited the antidiabetic activity of plant extracts, but this activity could be improved through the conversion of plant bioactives into metal nanoparticles. Aqueous plant extracts were prepared from two plants, Zingiber officinale and Mentha longifolia. Silver nanoparticles from aqueous plant extracts were synthesized and characterized through spectroscopic techniques, including ultraviolet–visible spectroscopy and Fourier transform infrared spectroscopy and scanning electron microscopy, in comparison with their respective plant extracts. After successful synthesis, these nanoparticles were evaluated for biological potentials of antioxidant, antimicrobial and antidiabetic activities. The nanoparticles of both plants offered outstanding antidiabetic potential, but the silver nanoparticles of Z. officinale showed the highest inhibition potential of 80.52% to α-amylase even at lower concentrations. The synthesized nanoparticles were found to be better antimicrobial agents against Bacillus subtilis and Escherichia coli as measured through a well diffusion assay as compared with aqueous extracts. These nanoparticles offered antioxidant potential that was better than that of their plant extracts but was slightly lower than that of the positive control gallic acid. This study gives a direction for improvement of the biological activity of plant-based medicine through green synthesis of silver nanoparticles.
迄今为止,已有各种报道表明植物提取物具有抗糖尿病活性,但这种活性可以通过将植物生物活性转化为金属纳米颗粒来提高。以生姜和薄荷两种植物为原料制备水提物。通过紫外可见光谱、傅里叶变换红外光谱和扫描电镜等光谱技术,合成了植物水提取物中的纳米银,并对其进行了表征。合成成功后,对这些纳米颗粒进行了抗氧化、抗菌和抗糖尿病活性的生物学评价。两种植物的纳米颗粒均具有显著的抗糖尿病作用,但在较低浓度下,银纳米颗粒对α-淀粉酶的抑制作用最高,达到80.52%。通过孔扩散实验,与水提取物相比,合成的纳米颗粒对枯草芽孢杆菌和大肠杆菌具有更好的抗菌作用。这些纳米颗粒提供的抗氧化潜力优于其植物提取物,但略低于阳性对照没食子酸。本研究为绿色合成纳米银提高植物性药物的生物活性指明了方向。
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引用次数: 0
Preparation of Mg/PCL electrospun membranes and preliminary study Mg/PCL静电纺膜的制备及初步研究
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-09-02 DOI: 21.00028
Maheshati Abudihani, Yijun Yu, Qingqing Wang, Leiying Miao
Magnesium (Mg) metal and its alloy degradation product magnesium ion (Mg2+) can stimulate the metabolic activity of bone cells, which is beneficial to bone growth and healing. With biodegradable polycaprolactone (PCL) and magnesium particles as raw materials, electrospinning technology is used to prepare electrospun membrane materials doped with magnesium particles. Meanwhile, the scanning electron microscope, X-ray diffraction analysis technology and microcomputer-controlled electronic universal testing machine are adopted to analyze the physical and chemical properties of the material. The biocompatibility of electrospun membranes and their potential to induce osteogenic differentiation of human dental pulp stem cells (hDPSCs) were evaluated by in vitro cell experiments. The results showed that magnesium/PCL electrospun membranes doped with magnesium particles were successfully prepared with electrospinning technology, and the material has a good porous structure. Magnesium/PCL electrospun membranes have good biocompatibility and have the potential to induce osteogenic differentiation of hDPSCs. Among them, the effects of 10% magnesium/PCL electrospun membranes were the most obvious. Clinically, these materials provide new ideas for the restoration of alveolar bone defects and provide an experimental basis for the realization of alveolar bone regeneration.
金属镁(Mg)及其合金降解产物镁离子(Mg2+)能刺激骨细胞的代谢活性,有利于骨的生长和愈合。以可生物降解聚己内酯(PCL)和镁颗粒为原料,采用静电纺丝技术制备掺杂镁颗粒的静电纺丝膜材料。同时,采用扫描电子显微镜、x射线衍射分析技术和微机控制的电子万能试验机对材料的物理化学性能进行分析。通过体外细胞实验,评价了电纺丝膜的生物相容性及其诱导人牙髓干细胞成骨分化的潜力。结果表明,采用静电纺丝技术成功制备了掺杂镁颗粒的镁/PCL静电纺丝膜,该材料具有良好的多孔结构。镁/PCL电纺丝膜具有良好的生物相容性,具有诱导hdpsc成骨分化的潜力。其中,10%镁/PCL静电纺膜的效果最为明显。在临床上,这些材料为牙槽骨缺损的修复提供了新的思路,为实现牙槽骨再生提供了实验依据。
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引用次数: 0
Chitosan-based nanoparticles for controlled release of hydrophobic and hydrophilic drugs 壳聚糖基纳米颗粒控制疏水和亲水药物的释放
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-09-02 DOI: 21.00009
Jing Zhao, Xiaoran Wang, Xingyue Deng, Kaiwen Liu
Nanoparticles encapsulating different kinds of therapeutic drugs are promising drug delivery systems for controlling release and targeting tumor cells. Chitosan nanoparticles made by polyelectrolyte complexation were designed as drug carriers using doxorubicin (DOX)/5-fluorouracil (5-FU) as hydrophobic/hydrophilic model drugs. The sizes of nanoparticles were 235 ± 13 and 177 ± 7 nm with narrow distributions. The effects of the initial drug amount and pH of the medium on drug-controlled release properties were evaluated, the model-fitting results and release mechanisms were analyzed as well. For 5-FU-loaded chitosan nanoparticles, the controlled-release effect was superior to that of DOX, indicating that the polyelectrolyte complex nanoparticles were more suitable for hydrophilic drugs, particularly for negatively charged or electrically neutral drugs. Moreover, the release behaviors conformed with the first-order kinetic model, indicating that the nanoparticles were mainly released by diffusion during the drug release process; the system could also be fitted using the Higuchi model, showing that the entire drug release process was dominated by diffusion and supplemented by gradual dissolution. In all, the results suggested that chitosan nanoparticles made by polyelectrolyte complexation can be launched as a smart drug delivery system for cancer treatments.
纳米颗粒包裹不同类型的治疗药物是一种很有前途的药物递送系统,用于控制肿瘤细胞的释放和靶向肿瘤细胞。以多柔比星(DOX)/5-氟尿嘧啶(5-FU)为亲疏水模型药物,设计多电解质络合法制备的壳聚糖纳米颗粒作为药物载体。纳米颗粒尺寸分别为235±13 nm和177±7 nm,分布较窄。考察了初始给药量和培养液pH对药物控释性能的影响,并对模型拟合结果和释放机制进行了分析。对于负载5- fu的壳聚糖纳米颗粒,其控释效果优于DOX,表明多电解质复合物纳米颗粒更适合于亲水药物,特别是负电荷或电中性药物。释放行为符合一级动力学模型,表明在药物释放过程中,纳米颗粒主要以扩散释放;该系统也可以使用Higuchi模型进行拟合,表明整个药物释放过程以扩散为主,逐渐溶解为辅。总之,研究结果表明,由多电解质络合制成的壳聚糖纳米颗粒可以作为一种智能药物输送系统用于癌症治疗。
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引用次数: 0
Nature-inspired slippery polymer thin film for ice-repellent applications 受自然启发的光滑聚合物薄膜,用于防冰应用
4区 工程技术 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2021-09-02 DOI: 21.00027
Vu Thi Hong Hanh, Mai Xuan Truong, Tu Quang Tan, Thanh-Binh Nguyen
In this study, the authors investigated the anti-icing performance of a hierarchical slippery polymer thin film that is inspired by structures of the lotus leaf and Nepenthes pitcher plant. The polymer solution was mixed with the lubricant at the appropriate concentration to achieve slippery properties. The dry etching method followed by the spin-coating process was used to generate a uniform polymer microstructure on the thin film. The polymer nanostructure was then yielded by an additional plasma-etching method using carbon tetrafluoride (CF4) gas. The anti-icing efficiency was then compared with that of the non-functional samples to demonstrate the advantages of combination in all criteria. Moreover, a theoretical prediction based on the free-energy approach was used to measure the nucleation time at the interface and illustrated good agreement with real-time measurement. The results propose a new and facile approach for outdoor anti-icing applications.
在这项研究中,作者研究了一种分层光滑聚合物薄膜的防冰性能,这种薄膜的灵感来自荷叶和猪笼草的结构。将聚合物溶液与适当浓度的润滑剂混合以获得光滑性能。采用干刻蚀法和旋涂法在薄膜上生成均匀的聚合物微观结构。聚合物纳米结构随后通过使用四氟化碳(CF4)气体的附加等离子体蚀刻方法产生。通过与非功能试件的抗冰效果对比,验证了各指标组合的优势。此外,利用基于自由能方法的理论预测方法测量了界面处的成核时间,结果与实时测量结果吻合较好。研究结果为室外防冰应用提供了一种新的简便方法。
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引用次数: 0
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Bioinspired Biomimetic and Nanobiomaterials
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