This study was designed to evaluate whether nano-hydroxyapatite toothpastes with or without fluoride would be more advantageous than a fluoride toothpaste in the repair of eroded enamel in situ. Twenty-one subjects participated in this single-blind, randomized, cross-over design study with three 7-day treatment phases. In each phase, the subjects wearing a palatal appliance containing five sterilized enamel specimens used either one of the two test regimens (1% nano-hydroxyapatite toothpaste and 2.25% nano-hydroxyapatite/1450 parts per million (ppm) fluoride toothpaste) or one control (1400 ppm fluoride toothpaste). Enamel specimens were extraorally demineralized (4 × 5 min/day) and were intraorally treated with the toothpastes (2 × 2 min/day). The nano-hydroxyapatite toothpaste groups exhibited significantly higher surface microhardness than did the standard fluoride toothpaste group (p < 0.05). Enamel surface hardness was increased only by nano-hydroxyapatite toothpastes after in situ treatment compared with the baseline (p < 0.05). Morphological analysis demonstrated an apatite-type crystal deposition on the eroded enamel surface produced by nano-hydroxyapatite toothpastes, while fluoride toothpaste failed to show any significant surface deposition. Chemical analysis showed a higher content of calcium and phosphorus in the enamel surface treated with nano-hydroxyapatite toothpastes compared with that in the control one (p < 0.05). It is concluded that home use of nano-hydroxyapatite containing toothpastes may have a protective effect against erosion at the enamel surface.
{"title":"The in situ potential of synthetic nano-hydroxyapatite for tooth enamel repair","authors":"S Gokce Ince, R Banu Ermis","doi":"21.00022","DOIUrl":"https://doi.org/21.00022","url":null,"abstract":"This study was designed to evaluate whether nano-hydroxyapatite toothpastes with or without fluoride would be more advantageous than a fluoride toothpaste in the repair of eroded enamel in situ. Twenty-one subjects participated in this single-blind, randomized, cross-over design study with three 7-day treatment phases. In each phase, the subjects wearing a palatal appliance containing five sterilized enamel specimens used either one of the two test regimens (1% nano-hydroxyapatite toothpaste and 2.25% nano-hydroxyapatite/1450 parts per million (ppm) fluoride toothpaste) or one control (1400 ppm fluoride toothpaste). Enamel specimens were extraorally demineralized (4 × 5 min/day) and were intraorally treated with the toothpastes (2 × 2 min/day). The nano-hydroxyapatite toothpaste groups exhibited significantly higher surface microhardness than did the standard fluoride toothpaste group (<i>p</i> < 0.05). Enamel surface hardness was increased only by nano-hydroxyapatite toothpastes after in situ treatment compared with the baseline (<i>p</i> < 0.05). Morphological analysis demonstrated an apatite-type crystal deposition on the eroded enamel surface produced by nano-hydroxyapatite toothpastes, while fluoride toothpaste failed to show any significant surface deposition. Chemical analysis showed a higher content of calcium and phosphorus in the enamel surface treated with nano-hydroxyapatite toothpastes compared with that in the control one (<i>p</i> < 0.05). It is concluded that home use of nano-hydroxyapatite containing toothpastes may have a protective effect against erosion at the enamel surface.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138512652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Hạnh, M. Truong, Từ Quang Tân, Thanh-Binh Nguyen
{"title":"Nature-inspired slippery polymer thin film for ice-repellent applications","authors":"V. Hạnh, M. Truong, Từ Quang Tân, Thanh-Binh Nguyen","doi":"10.1680/jbibn.21.00027","DOIUrl":"https://doi.org/10.1680/jbibn.21.00027","url":null,"abstract":"","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47197064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study was designed to evaluate whether nano-hydroxyapatite toothpastes with or without fluoride would be more advantageous than a fluoride toothpaste in the repair of eroded enamel in situ. Tw...
本研究旨在评估含氟或不含氟纳米羟基磷灰石牙膏在原位修复侵蚀牙釉质方面是否比含氟牙膏更有利。Tw……
{"title":"The in situ potential of synthetic nano-hydroxyapatite for tooth enamel repair","authors":"InceS Gokce, Banu ErmisR","doi":"10.1680/JBIBN.21.00022","DOIUrl":"https://doi.org/10.1680/JBIBN.21.00022","url":null,"abstract":"This study was designed to evaluate whether nano-hydroxyapatite toothpastes with or without fluoride would be more advantageous than a fluoride toothpaste in the repair of eroded enamel in situ. Tw...","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44663033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magnesium metal and its alloy degradation product magnesium ion (Mg2+) can stimulate the metabolic activity of bone cells, which is beneficial to bone growth and healing. With biodegradable polycap...
{"title":"Preparation of Mg/PCL Electrospun Membranes and Preliminary Study","authors":"AbudihaniMaheshati, YuYijun, WangQingqing, MiaoLeiying","doi":"10.1680/JBIBN.21.00028","DOIUrl":"https://doi.org/10.1680/JBIBN.21.00028","url":null,"abstract":"Magnesium metal and its alloy degradation product magnesium ion (Mg2+) can stimulate the metabolic activity of bone cells, which is beneficial to bone growth and healing. With biodegradable polycap...","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41454712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To date, various reports have exhibited anti-diabetic activity of plant extracts, but this activity could be improved through the conversion of plant bio-actives into metal nanoparticles. Aqueous p...
{"title":"Bioactivity Guided Nanoparticle Synthesis from Zingiber officinale and Mentha longifolia","authors":"SarfrazRaja Adil, AshrafRizwan, BediSaira, SardarIqra","doi":"10.1680/JBIBN.21.00018","DOIUrl":"https://doi.org/10.1680/JBIBN.21.00018","url":null,"abstract":"To date, various reports have exhibited anti-diabetic activity of plant extracts, but this activity could be improved through the conversion of plant bio-actives into metal nanoparticles. Aqueous p...","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46026844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanoparticles encapsulated with different kinds of therapeutic drugs are promising drug delivery systems for controlling release and targeting tumor cells. Chitosan nanoparticles made of polyelectr...
{"title":"Chitosan Nanoparticles as a Carrier System for Controlled Dual Release of Hydrophobic and Hydrophilic Drugs","authors":"Zhaojing, WangXiaoran, DengXingyue, LiuKaiwen","doi":"10.1680/JBIBN.21.00009","DOIUrl":"https://doi.org/10.1680/JBIBN.21.00009","url":null,"abstract":"Nanoparticles encapsulated with different kinds of therapeutic drugs are promising drug delivery systems for controlling release and targeting tumor cells. Chitosan nanoparticles made of polyelectr...","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46313319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cartilage is an avascular and aneural connective tissue with poor self-healing capability. Recently, tissue engineering opens up new horizons for staving off or treating cartilage lesions. In this work, kartogenin (KGN), a small chondro-inductive molecule, was loaded into poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), which in turn was embedded in a silk fibroin (SF) scaffold, to prepare an appropriate microenvironment for mesenchymal stem cell (MSC) differentiation. In this research, SF was opted to serve as a scaffold based on its approved biocompatibility and non-toxicity, excellent mechanical properties and processability. The data obtained from this study show that entrapment of KGN in NPs provides sustained release, which could promote the differentiation of MSCs into chondrocytes. Likewise, the scaffold containing KGN-loaded NPs induces glycosaminoglycan production by the seeded MSCs. The introduction of NPs into the scaffold, meanwhile, elevated the compressive strength of the structures (more than two times) without any significant effect on their swelling behavior. Taken together, the authors’ findings demonstrate that the prepared scaffold, with an optimal structure, could be a potential candidate for cartilage tissue regeneration.
{"title":"Effects of kartogenin/PLGA nanoparticles on silk scaffold properties and stem cell fate","authors":"Maryam Rezvaninia, Fatemeh Bagheri, Nafiseh Baheiraei","doi":"20.00047","DOIUrl":"https://doi.org/20.00047","url":null,"abstract":"Cartilage is an avascular and aneural connective tissue with poor self-healing capability. Recently, tissue engineering opens up new horizons for staving off or treating cartilage lesions. In this work, kartogenin (KGN), a small chondro-inductive molecule, was loaded into poly(lactic-<i>co</i>-glycolic acid) (PLGA) nanoparticles (NPs), which in turn was embedded in a silk fibroin (SF) scaffold, to prepare an appropriate microenvironment for mesenchymal stem cell (MSC) differentiation. In this research, SF was opted to serve as a scaffold based on its approved biocompatibility and non-toxicity, excellent mechanical properties and processability. The data obtained from this study show that entrapment of KGN in NPs provides sustained release, which could promote the differentiation of MSCs into chondrocytes. Likewise, the scaffold containing KGN-loaded NPs induces glycosaminoglycan production by the seeded MSCs. The introduction of NPs into the scaffold, meanwhile, elevated the compressive strength of the structures (more than two times) without any significant effect on their swelling behavior. Taken together, the authors’ findings demonstrate that the prepared scaffold, with an optimal structure, could be a potential candidate for cartilage tissue regeneration.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138526649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manipulation of protein crystals using an external field is a topic of growing interest in several fields, such as X-ray crystallography and crystal processing. The aim of this study was to develop a method for manipulating crystals using a magnetic field by assembling iron oxide nanoparticles inside a lysozyme crystal. Poly(vinylpyrrolidone)-stabilised iron oxide nanoparticles, prepared through pulsed laser ablation in a solution, were preferentially incorporated in the {101} sectors rather than in the {110} sectors of the tetragonal lysozyme crystal, similar to the gold (Au) and platinum (Pt) nanoparticles studied previously. To keep the crystals intact in solutions, the outer surface of the nanoparticle-assembled crystal was coated with a pure lysozyme crystal and the coated crystals were introduced into a solution containing glycerol. The pure lysozyme crystal at the surface of the nanoparticle-assembled crystal is less likely to dissolve compared with the nanoparticle-assembled crystal itself. Additionally, glycerol has a delaying effect on the dissolution of crystals owing to its high viscosity. The authors successfully demonstrated the handling of protein crystals by commercially available needle magnets in solution. This method requires a simple device with a low cost, without any requirement for control conditions and energy, thus facilitating easy and inexpensive handling of the crystal.
{"title":"Manipulation of protein crystals using a magnetic field by assembling Fe x O y nanoparticles","authors":"Yoshihiro Takeda, Fumitaka Mafuné","doi":"20.00073","DOIUrl":"https://doi.org/20.00073","url":null,"abstract":"Manipulation of protein crystals using an external field is a topic of growing interest in several fields, such as X-ray crystallography and crystal processing. The aim of this study was to develop a method for manipulating crystals using a magnetic field by assembling iron oxide nanoparticles inside a lysozyme crystal. Poly(vinylpyrrolidone)-stabilised iron oxide nanoparticles, prepared through pulsed laser ablation in a solution, were preferentially incorporated in the {101} sectors rather than in the {110} sectors of the tetragonal lysozyme crystal, similar to the gold (Au) and platinum (Pt) nanoparticles studied previously. To keep the crystals intact in solutions, the outer surface of the nanoparticle-assembled crystal was coated with a pure lysozyme crystal and the coated crystals were introduced into a solution containing glycerol. The pure lysozyme crystal at the surface of the nanoparticle-assembled crystal is less likely to dissolve compared with the nanoparticle-assembled crystal itself. Additionally, glycerol has a delaying effect on the dissolution of crystals owing to its high viscosity. The authors successfully demonstrated the handling of protein crystals by commercially available needle magnets in solution. This method requires a simple device with a low cost, without any requirement for control conditions and energy, thus facilitating easy and inexpensive handling of the crystal.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138526696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study focuses on the development of carboxymethylcellulose (CMC)–biphasic calcium phosphate (BCP) composite scaffolds through the freeze-drying process for bone tissue engineering applications. Citric acid or fumaric acid was added as the cross-linker of CMC to improve the stability of composite scaffolds. The effect of change in freezing temperature (−20, −40 or −80°C) on the pore morphology, swelling ability and mechanical properties of composite scaffolds was studied. Cross-linked scaffolds showed an increased thermal degradation temperature compared with non-cross-linked scaffolds. All the composite scaffolds showed a porous structure with homogeneous blending of CMC and BCP. Cross-linked scaffolds showed appreciable swelling ability and stability in phosphate-buffered saline, while non-cross-linked scaffolds were unstable for 24 h. Cross-linked scaffolds had lower compressive strength than non-cross-linked scaffolds under dry conditions. However, in the hydrated state, only citric acid-cross-linked scaffolds were stable with improved compressive strength of 64 ± 4, 57 ± 4 and 67 ± 4 kPa when processed at −20, −40 and −80°C, respectively. Furthermore, three-dimensional culture of Saos-2 cells on citric acid-cross-linked scaffolds showed their suitability for cell proliferation and osteogenic differentiation. Therefore, citric acid-cross-linked CMC–BCP composite scaffolds may be promising scaffolds for bone tissue engineering applications.
{"title":"Development of carboxymethylcellulose based composites for bone tissue engineering","authors":"Ganesan Priya, Uttamchand Narendra Kumar, Balaraman Madhan, Inderchand Manjubala","doi":"20.00045","DOIUrl":"https://doi.org/20.00045","url":null,"abstract":"The present study focuses on the development of carboxymethylcellulose (CMC)–biphasic calcium phosphate (BCP) composite scaffolds through the freeze-drying process for bone tissue engineering applications. Citric acid or fumaric acid was added as the cross-linker of CMC to improve the stability of composite scaffolds. The effect of change in freezing temperature (−20, −40 or −80°C) on the pore morphology, swelling ability and mechanical properties of composite scaffolds was studied. Cross-linked scaffolds showed an increased thermal degradation temperature compared with non-cross-linked scaffolds. All the composite scaffolds showed a porous structure with homogeneous blending of CMC and BCP. Cross-linked scaffolds showed appreciable swelling ability and stability in phosphate-buffered saline, while non-cross-linked scaffolds were unstable for 24 h. Cross-linked scaffolds had lower compressive strength than non-cross-linked scaffolds under dry conditions. However, in the hydrated state, only citric acid-cross-linked scaffolds were stable with improved compressive strength of 64 ± 4, 57 ± 4 and 67 ± 4 kPa when processed at −20, −40 and −80°C, respectively. Furthermore, three-dimensional culture of Saos-2 cells on citric acid-cross-linked scaffolds showed their suitability for cell proliferation and osteogenic differentiation. Therefore, citric acid-cross-linked CMC–BCP composite scaffolds may be promising scaffolds for bone tissue engineering applications.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138526653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manipulation of protein crystals using an external field is a topic of growing interest in several fields, such as X-ray crystallography and crystal processing. The aim of this study was to develop...
{"title":"Manipulation of protein crystals using a magnetic field by assembling Fe x O y nanoparticles","authors":"Y. Takeda, F. Mafuné","doi":"10.1680/jbibn.20.00073","DOIUrl":"https://doi.org/10.1680/jbibn.20.00073","url":null,"abstract":"Manipulation of protein crystals using an external field is a topic of growing interest in several fields, such as X-ray crystallography and crystal processing. The aim of this study was to develop...","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46191035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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