Iron oxide nanoparticles (NPs) have recently attracted wider attention because of their unique properties, such as superparamagnetism, larger surface area, surface-to-volume ratio, and simple manufacturing process. Several chemical, physical, and biological techniques have been employed to synthesize NPs with admissible surface chemistry. This paper summarises the approaches for producing iron oxide NPs, shape, and size management, and inviting properties in bioengineering, pharmaceutical, and modern applications. Iron oxides have significant potential in biology, climate change, and horticulture, among other fields. Surface coatings with organic or inorganic particles are one of a kind. The surface coatings of the IONPs are critical to their performance because they prevent nanoparticle aggregation, reduce the risk of immunogenicity, and limit nonspecific cellular uptake. Chitosan is a biodegradable polymer that is applied to iron oxide nanoparticles to coat them. Chitosan subordinates like O-HTCC (an ammonium-quaternary CS subsidiary) have a long-lasting positive charge that allows them to work in different pH ranges allowing their interactions with cell layers at physiological pH. By reacting epoxy propyl trimethyl ammonium chloride (ETA) with chitosan (CS), the hydro-solvent N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTCC) is formed. For hyperthermic treatment of patients, NPs can also be coordinated to an organ, tissue, or tumor via an external attractive field. Given the increasing interest in iron NPs, the purpose of this review is to present data from iron oxide nanoparticles specially chitosan-capped iron NPs for different biomedical fields.
{"title":"Synthesis of iron oxide nanoparticles, characterization, applications as nanozyme, and future prospects","authors":"Fouzia Tanvir, Nimra Sadar, A. Yaqub, S. A. Ditta","doi":"10.1680/jbibn.21.00068","DOIUrl":"https://doi.org/10.1680/jbibn.21.00068","url":null,"abstract":"Iron oxide nanoparticles (NPs) have recently attracted wider attention because of their unique properties, such as superparamagnetism, larger surface area, surface-to-volume ratio, and simple manufacturing process. Several chemical, physical, and biological techniques have been employed to synthesize NPs with admissible surface chemistry. This paper summarises the approaches for producing iron oxide NPs, shape, and size management, and inviting properties in bioengineering, pharmaceutical, and modern applications. Iron oxides have significant potential in biology, climate change, and horticulture, among other fields. Surface coatings with organic or inorganic particles are one of a kind. The surface coatings of the IONPs are critical to their performance because they prevent nanoparticle aggregation, reduce the risk of immunogenicity, and limit nonspecific cellular uptake. Chitosan is a biodegradable polymer that is applied to iron oxide nanoparticles to coat them. Chitosan subordinates like O-HTCC (an ammonium-quaternary CS subsidiary) have a long-lasting positive charge that allows them to work in different pH ranges allowing their interactions with cell layers at physiological pH. By reacting epoxy propyl trimethyl ammonium chloride (ETA) with chitosan (CS), the hydro-solvent N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTCC) is formed. For hyperthermic treatment of patients, NPs can also be coordinated to an organ, tissue, or tumor via an external attractive field. Given the increasing interest in iron NPs, the purpose of this review is to present data from iron oxide nanoparticles specially chitosan-capped iron NPs for different biomedical fields.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45782924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sadia Pervez Lali, M. Sher, M. Hussain, A. Fatima, M. Naeem-ul-Hassan, Maqsood Ahmed, S. N. Bukhari
The aim of this study was to develop solid dispersions (SDs) of Clarithromycin (CLA) using hydrophilic polymer hydroxypropyl- methylcellulose (HPMC) and Xanthan Gum (XNG) as drug carrier. The in vitro dissolution study was performed in dissolution media of pH 6.8 and compared with that of standard drugs. In vivo pharmacokinetic studies were carried out on animal model (rabbits).The thermal behavior of each SDs formulation was studied by differential scanning calorimetry (DSC) analysis. The results concluded that crystalline nature of CLA has been transformed to amorphous form in SDs. Pharmacokinetic parameters were observed to be improved in HPMC as well as XNG based SDs than that of standard drugs. Additionally, powder X-ray diffraction (PXRD) analysis also confirmed the phase transition (crystalline to amorphous) of drug present in SDs. The higher values of Cmax, were found in case of HPMC based SDs, whereas, tmax values were prolonged in SDs based on XNG. Additionally, enhanced half-life values predicted that SDs would have potential to achieve once daily dose and improved patient compliance of drugs. Hence, the formulated SDs of poorly soluble drug, based on HPMC and XNG as carriers, exhibited more hydrophilic nature with enhanced aqueous solubility and therefore improved bioavailability as compared to that of standard drug.
{"title":"In vitro and In vivo evaluation of clarithromycin solid dispersion prepared via spray drying technique","authors":"Sadia Pervez Lali, M. Sher, M. Hussain, A. Fatima, M. Naeem-ul-Hassan, Maqsood Ahmed, S. N. Bukhari","doi":"10.1680/jbibn.21.00065","DOIUrl":"https://doi.org/10.1680/jbibn.21.00065","url":null,"abstract":"The aim of this study was to develop solid dispersions (SDs) of Clarithromycin (CLA) using hydrophilic polymer hydroxypropyl- methylcellulose (HPMC) and Xanthan Gum (XNG) as drug carrier. The in vitro dissolution study was performed in dissolution media of pH 6.8 and compared with that of standard drugs. In vivo pharmacokinetic studies were carried out on animal model (rabbits).The thermal behavior of each SDs formulation was studied by differential scanning calorimetry (DSC) analysis. The results concluded that crystalline nature of CLA has been transformed to amorphous form in SDs. Pharmacokinetic parameters were observed to be improved in HPMC as well as XNG based SDs than that of standard drugs. Additionally, powder X-ray diffraction (PXRD) analysis also confirmed the phase transition (crystalline to amorphous) of drug present in SDs. The higher values of Cmax, were found in case of HPMC based SDs, whereas, tmax values were prolonged in SDs based on XNG. Additionally, enhanced half-life values predicted that SDs would have potential to achieve once daily dose and improved patient compliance of drugs. Hence, the formulated SDs of poorly soluble drug, based on HPMC and XNG as carriers, exhibited more hydrophilic nature with enhanced aqueous solubility and therefore improved bioavailability as compared to that of standard drug.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42582879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabere Nouri, Fatemeh Yousef-Saber, G. Emtiazi, N. Habibi
Background: The unique physicochemical properties of nano-metals compared to non-nano materials has led to many investigations in recent decades. Nano-Titanium dioxide has been chiefly applied in novel implant forms. In addition, the structures of Selenium-containing compounds play a critical role in the biological activity of these elements. According to recent studies, nano-Selenium is not only less toxic but also has higher biological activity than Selenium ions such as Se4+ and Se6+. Methods: Researchers have turned to green nano-structure synthesis due to drawbacks of chemical techniques. This article presents a literature review on recent advances in microbial synthesis methods to produce nano-Selenium and nano-Titanium dioxide. Results: Despite numerous research articles on green nanoparticle production, little information has been provided on the microbial formation of Titanium and Selenium nanoparticles. This review article focuses on the possible mechanism of nano-Selenium production by Selenium respiration. Although there are reports of microbial synthesis of these particles, their production by probiotic bacteria is of great value. Conclusion: Considering the compatibility of probiotic bacteria with the immune system and their tremendous applications in medicine, it is suggested to use them in combination with nano-Titanium dioxide and nano-Selenium for various ends such as implant scaffolds and food additives, respectively.
{"title":"Microbial synthesis of nano-selenium and nano-titanium dioxide: mechanisms of selenite respiration","authors":"Sabere Nouri, Fatemeh Yousef-Saber, G. Emtiazi, N. Habibi","doi":"10.1680/jbibn.21.00064","DOIUrl":"https://doi.org/10.1680/jbibn.21.00064","url":null,"abstract":"Background: The unique physicochemical properties of nano-metals compared to non-nano materials has led to many investigations in recent decades. Nano-Titanium dioxide has been chiefly applied in novel implant forms. In addition, the structures of Selenium-containing compounds play a critical role in the biological activity of these elements. According to recent studies, nano-Selenium is not only less toxic but also has higher biological activity than Selenium ions such as Se4+ and Se6+. Methods: Researchers have turned to green nano-structure synthesis due to drawbacks of chemical techniques. This article presents a literature review on recent advances in microbial synthesis methods to produce nano-Selenium and nano-Titanium dioxide. Results: Despite numerous research articles on green nanoparticle production, little information has been provided on the microbial formation of Titanium and Selenium nanoparticles. This review article focuses on the possible mechanism of nano-Selenium production by Selenium respiration. Although there are reports of microbial synthesis of these particles, their production by probiotic bacteria is of great value. Conclusion: Considering the compatibility of probiotic bacteria with the immune system and their tremendous applications in medicine, it is suggested to use them in combination with nano-Titanium dioxide and nano-Selenium for various ends such as implant scaffolds and food additives, respectively.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48988936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Magnetic nanoparticles are the main source of synthesis and design of magnetic nanocatalysts, which are obtained from iron salts by chemical co-precipitation method. Objective: The main goal of this research is to investigate the absorption, release and antibacterial properties of magnetic nanocatalysts with silica coating and silica/amine linker. Methods: The structure of the obtained nanocatalyst is detected by several analyzes such as SEM, TEM, EDX and IR. Results: Here is reaction between the ampicillin 10 µl (25 µg/ml) and the Fe3O4@SiO2 and Fe3O4@SiO2/NH magnetic nanocatalyst 200 mg (2 mole%), under 25°C and double distilled water. In this way, the amount of absorbed ampicillin on MNPs@silica/amine structure in covalent is more than MNPs@silica structure in non-covalent bonding, i.e. 85 to 65%, but the rate of release in non-covalent is above 90%, but in covalent is less than 80%. Also, the bactericidal properties of nanocatalysts have been tested separately at a temperature of 37 degrees for the non-covalent type are more than 80% compared to Covalance form is 70%. Conclusions: The overall result was that the percentage efficiency of the absorption/release reaction in the non-covalent bonding state was much better and about 10% more release.
{"title":"A strong system of magnetic nanocatalysts in absorbing and releasing ampicillin along with its antibacterial properties","authors":"M. Binandeh","doi":"10.1680/jbibn.21.00066","DOIUrl":"https://doi.org/10.1680/jbibn.21.00066","url":null,"abstract":"Background: Magnetic nanoparticles are the main source of synthesis and design of magnetic nanocatalysts, which are obtained from iron salts by chemical co-precipitation method. Objective: The main goal of this research is to investigate the absorption, release and antibacterial properties of magnetic nanocatalysts with silica coating and silica/amine linker. Methods: The structure of the obtained nanocatalyst is detected by several analyzes such as SEM, TEM, EDX and IR. Results: Here is reaction between the ampicillin 10 µl (25 µg/ml) and the Fe3O4@SiO2 and Fe3O4@SiO2/NH magnetic nanocatalyst 200 mg (2 mole%), under 25°C and double distilled water. In this way, the amount of absorbed ampicillin on MNPs@silica/amine structure in covalent is more than MNPs@silica structure in non-covalent bonding, i.e. 85 to 65%, but the rate of release in non-covalent is above 90%, but in covalent is less than 80%. Also, the bactericidal properties of nanocatalysts have been tested separately at a temperature of 37 degrees for the non-covalent type are more than 80% compared to Covalance form is 70%. Conclusions: The overall result was that the percentage efficiency of the absorption/release reaction in the non-covalent bonding state was much better and about 10% more release.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47622440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niyousha Yazdanmehr, M. Tajabadi, R. Bigdeli, Hanif Goran Orimi, V. Asgary
Biological barriers could be overcome using nano-biotechnology, which promotes the development of nanomaterial-based delivery systems. The primary objective of the present investigation focuses on superparamagnetic iron oxide nanoparticle (SPION) production for the delivery of topotecan to human breast cancer cells (MCF-7). The XRD results confirm the formation of pure SPION. The FTIR spectra indicate the functional groups related to aminopropyl trimethoxy silane (APTS) as a coating agent and topotecan. Topotecan-loaded magnetite nanoparticles with an IC50 of approximately 156 µg/mL exhibited dose-dependent cytotoxicity. The PCR method also proved that, in the mentioned cell line, topotecan-loaded SPION could increase the Bax/Bcl2 ratio and P53 gene expression. Annexin V/PI detection assay was done in order to detect the induction of apoptosis. According to the results, the nanoparticles inhibitively influence the survival of the MCF-7 breast cancer cells via boosting apoptosis, which helps to slow the growth of tumor cells.
{"title":"Apoptotic-based topotecan-loaded superparamagnetic drug delivery system: an in vitro study in MCF7","authors":"Niyousha Yazdanmehr, M. Tajabadi, R. Bigdeli, Hanif Goran Orimi, V. Asgary","doi":"10.1680/jbibn.21.00053","DOIUrl":"https://doi.org/10.1680/jbibn.21.00053","url":null,"abstract":"Biological barriers could be overcome using nano-biotechnology, which promotes the development of nanomaterial-based delivery systems. The primary objective of the present investigation focuses on superparamagnetic iron oxide nanoparticle (SPION) production for the delivery of topotecan to human breast cancer cells (MCF-7). The XRD results confirm the formation of pure SPION. The FTIR spectra indicate the functional groups related to aminopropyl trimethoxy silane (APTS) as a coating agent and topotecan. Topotecan-loaded magnetite nanoparticles with an IC50 of approximately 156 µg/mL exhibited dose-dependent cytotoxicity. The PCR method also proved that, in the mentioned cell line, topotecan-loaded SPION could increase the Bax/Bcl2 ratio and P53 gene expression. Annexin V/PI detection assay was done in order to detect the induction of apoptosis. According to the results, the nanoparticles inhibitively influence the survival of the MCF-7 breast cancer cells via boosting apoptosis, which helps to slow the growth of tumor cells.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44768962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa Anahí Olvera Carreño, E. N. A. Mireles, E. Rocha-Rangel
Several natural materials have demonstrated excellent mechanical performance by using abundant resources and friendly chemistry. Additionally, these materials have evolved to optimize weight and maximize strength and energy absorption at the macro, micro, and nanostructural level. Likewise, engineers still face challenges regarding the same issues. Therefore, this paper aims to identify current literature on structural materials and their manufacturing methods. In this sense, a review was conducted to assess this extent in local databases through a research question and boolean operators. Results were classified into four main categories: plastic, metals, ceramic-composite materials, and organism-oriented structural materials, and their mechanical properties (energy absorption, fracture toughness, stiffness) were discussed. The results of this study can be generalized and easily comprehended by scientists, innovators, researchers, and the general public. This review contains structural materials where mechanical properties enhancement is of vital importance. Finally, this study illustrates how bio-inspiration provides a powerful tool to tune mechanical properties in diverse materials through structural arrangement and no significant modification to constituent materials composition. Likewise, it addresses trends in manufacturing processing routes and their scalability to drive further innovation within the field.
{"title":"Biologically inspired innovation: a review on structural materials and manufacturing methods","authors":"Melissa Anahí Olvera Carreño, E. N. A. Mireles, E. Rocha-Rangel","doi":"10.1680/jbibn.22.00027","DOIUrl":"https://doi.org/10.1680/jbibn.22.00027","url":null,"abstract":"Several natural materials have demonstrated excellent mechanical performance by using abundant resources and friendly chemistry. Additionally, these materials have evolved to optimize weight and maximize strength and energy absorption at the macro, micro, and nanostructural level. Likewise, engineers still face challenges regarding the same issues. Therefore, this paper aims to identify current literature on structural materials and their manufacturing methods. In this sense, a review was conducted to assess this extent in local databases through a research question and boolean operators. Results were classified into four main categories: plastic, metals, ceramic-composite materials, and organism-oriented structural materials, and their mechanical properties (energy absorption, fracture toughness, stiffness) were discussed. The results of this study can be generalized and easily comprehended by scientists, innovators, researchers, and the general public. This review contains structural materials where mechanical properties enhancement is of vital importance. Finally, this study illustrates how bio-inspiration provides a powerful tool to tune mechanical properties in diverse materials through structural arrangement and no significant modification to constituent materials composition. Likewise, it addresses trends in manufacturing processing routes and their scalability to drive further innovation within the field.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42117945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaijie Zhang, Xiangyu Zhang, Haibin Sun, Xiaowei Li, J. Bai, Qingyang Du, Chengfeng Li
Biocompatible hydroxyapatite (HAp) powders have thermodynamically driven tendencies to lower their surface areas due to the formation of irreversible aggregations. To address this challenge, HAp hybrid powders are herein prepared by a traditional wet-precipitation method with subsequent hydrothermal carbonization for surface modification. The crystallite size, crystallite degree and area ratio of the infrared peak assigned to bonding water versus that of free water are determined to investigate the variation of HAp crystallization with processing parameters. The crystallization of HAp is facilitated by enriched water in a stealth layer with water molecules evolved by citrate, N-contained methylene blue (MB), hydrogen groups-rich β-cyclodextrin (CD) and oxygen-contained organic carbon shells. The low surface areas result in fabrication of nano-sized HAp powders with uniform size distribution, well-dispersed morphologies and smooth surfaces through calcination of HAp-CD-MB@C. The pH values of acidic buffers increase slowly during incubation of HAp-CD-MB@C powders with chemical stability and large grain size after calcination at 550°C for 2 h. The present study will shed light on the preparation of nano-sized inorganic powders with uniform size distribution, well-dispersed morphologies and modulated chemical stabilities for their potential applications as carries of small molecular substances and fillers in composite materials.
{"title":"Increased chemical stabilities of well-dispersed hydroxyapatite (HAp) powders prepared by calcination of HAp-β-cyclodextrin-methylene blue@carbon","authors":"Kaijie Zhang, Xiangyu Zhang, Haibin Sun, Xiaowei Li, J. Bai, Qingyang Du, Chengfeng Li","doi":"10.1680/jbibn.21.00011","DOIUrl":"https://doi.org/10.1680/jbibn.21.00011","url":null,"abstract":"Biocompatible hydroxyapatite (HAp) powders have thermodynamically driven tendencies to lower their surface areas due to the formation of irreversible aggregations. To address this challenge, HAp hybrid powders are herein prepared by a traditional wet-precipitation method with subsequent hydrothermal carbonization for surface modification. The crystallite size, crystallite degree and area ratio of the infrared peak assigned to bonding water versus that of free water are determined to investigate the variation of HAp crystallization with processing parameters. The crystallization of HAp is facilitated by enriched water in a stealth layer with water molecules evolved by citrate, N-contained methylene blue (MB), hydrogen groups-rich β-cyclodextrin (CD) and oxygen-contained organic carbon shells. The low surface areas result in fabrication of nano-sized HAp powders with uniform size distribution, well-dispersed morphologies and smooth surfaces through calcination of HAp-CD-MB@C. The pH values of acidic buffers increase slowly during incubation of HAp-CD-MB@C powders with chemical stability and large grain size after calcination at 550°C for 2 h. The present study will shed light on the preparation of nano-sized inorganic powders with uniform size distribution, well-dispersed morphologies and modulated chemical stabilities for their potential applications as carries of small molecular substances and fillers in composite materials.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45824074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Captopril is an angiotensin-converting enzyme commonly used to treat high blood pressure and to improve survival after a heart attack. Considering the importance of the assay of this drug, we have proposed a simple and cost-effective colorimetric technique for the quantitative determination of it. The detection strategy was based on the redshift of the surface plasmon resonance band of silver nanoparticles (AgNps) induced by the action of captopril molecules. Under optimal experimental conditions, the interaction of AgNPs with captopril molecules in the presence of barium ions motivates the aggregation of AgNPs. The final result of this process is an observable change in the color of the tested solution from pale yellow to light brown. Our experiments showed that there is a linear relationship between the absorbance of AgNps solution and captopril concentration at about 720 nm, thus it is possible to assay the captopril amount just by measuring the absorbance of the examined solution at this wavelength. The calibration curve was linear in the range of 1.0 to 6.0 μM captopril with a detection limit equal to 0.4 μM. The proposed strategy was successfully applied to the determination of captopril in pharmaceutical preparations.
{"title":"A silver nanoparticle-based chemosensor for optical detection of captopril in pharmaceutical preparations","authors":"F. Bamdad, Farnaz Kazemzadeh","doi":"10.1680/jbibn.21.00056","DOIUrl":"https://doi.org/10.1680/jbibn.21.00056","url":null,"abstract":"Captopril is an angiotensin-converting enzyme commonly used to treat high blood pressure and to improve survival after a heart attack. Considering the importance of the assay of this drug, we have proposed a simple and cost-effective colorimetric technique for the quantitative determination of it. The detection strategy was based on the redshift of the surface plasmon resonance band of silver nanoparticles (AgNps) induced by the action of captopril molecules. Under optimal experimental conditions, the interaction of AgNPs with captopril molecules in the presence of barium ions motivates the aggregation of AgNPs. The final result of this process is an observable change in the color of the tested solution from pale yellow to light brown. Our experiments showed that there is a linear relationship between the absorbance of AgNps solution and captopril concentration at about 720 nm, thus it is possible to assay the captopril amount just by measuring the absorbance of the examined solution at this wavelength. The calibration curve was linear in the range of 1.0 to 6.0 μM captopril with a detection limit equal to 0.4 μM. The proposed strategy was successfully applied to the determination of captopril in pharmaceutical preparations.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48622577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. J. Stephen, Ankit Chokriwal, M. Sharma, D. Jain, J. Saxena, Harshdeep Dhaliwal, Vikram Sharma, Rajeev Mishra, Ramandeep Kaur, Abhijeet Singh
Neuroinflammation is a condition that contribute significantly to the pathogenesis and progression of several neurodegenerative disorders. Targeting neuroinflammation is a novel therapeutic approach for the treatment of these disorders. Dexamethasone is a steroidal based anti-inflammatory drug with the potential to treat neuroinflammation. However, in order to maintain the efficacy of the drug, dexamethasone needs to be coupled with an effective drug delivery vehicle to be able to be transported across Central Nervous System. PLGA nanoparticles has been used as drug delivery vehicles for transport of drugs into the central nervous system. The article describes the preparation and encapsulation of dexamethasone loaded PLGA nanoparticles by solvent evaporation method. Statistical Experimental Design approach was performed, wherein Response Surface Methodology was carried out to optimize the parameters associated with synthesis process. Further, kinetic modeling and drug release profile were also determined. The drug encapsulated nanoparticles were validated for its effectiveness in vitro. Toxicity studies revealed the nanodrug to be non-cytotoxic and Griess assay highlighted its ability to lower neuroinflammation. Further, genetic studies revealed the anti-inflammatory properties of the nanodrug was successfully in modulating neuroinflammation.
{"title":"Dexamethasone encapsulated PLGA nanoparticles as drug delivery vehicle for the treatment of neuroinflammation","authors":"B. J. Stephen, Ankit Chokriwal, M. Sharma, D. Jain, J. Saxena, Harshdeep Dhaliwal, Vikram Sharma, Rajeev Mishra, Ramandeep Kaur, Abhijeet Singh","doi":"10.1680/jbibn.21.00059","DOIUrl":"https://doi.org/10.1680/jbibn.21.00059","url":null,"abstract":"Neuroinflammation is a condition that contribute significantly to the pathogenesis and progression of several neurodegenerative disorders. Targeting neuroinflammation is a novel therapeutic approach for the treatment of these disorders. Dexamethasone is a steroidal based anti-inflammatory drug with the potential to treat neuroinflammation. However, in order to maintain the efficacy of the drug, dexamethasone needs to be coupled with an effective drug delivery vehicle to be able to be transported across Central Nervous System. PLGA nanoparticles has been used as drug delivery vehicles for transport of drugs into the central nervous system. The article describes the preparation and encapsulation of dexamethasone loaded PLGA nanoparticles by solvent evaporation method. Statistical Experimental Design approach was performed, wherein Response Surface Methodology was carried out to optimize the parameters associated with synthesis process. Further, kinetic modeling and drug release profile were also determined. The drug encapsulated nanoparticles were validated for its effectiveness in vitro. Toxicity studies revealed the nanodrug to be non-cytotoxic and Griess assay highlighted its ability to lower neuroinflammation. Further, genetic studies revealed the anti-inflammatory properties of the nanodrug was successfully in modulating neuroinflammation.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45057459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Untreated dental caries is an important word challenge in human life. In this work, we synthesized polyvinyl alcohol-gum arabic-magnesium oxide nanoparticles new bionanocomposite and evaluated the antibacterial properties of its against Streptococcus mutans biofilm in vitro. For optimization of variables to have the maximum antibacterial property, L9 orthogonal array of Taguchi method was used for design of extraction conditions. The nanocomposites were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), X-ray energy diffraction (EDS), Thermogravimetric analysis (TGA) and transmission electron microscopy (TEM) tests. The FESEM images of nanocomposite inhibit that the nanoparticles are entirely surrounded with polymers chains of matrix and nanoparticles are deposited on the its walls, thus a layered nanocomposite is formed. The sheet width and size range of the nanocomposite was determined between 30-40 and 20-90 nm, respectively. The results showed that the synthesized nanocomposite with conditions of 1 mg/ml PVA, 3 mg/ml AG, and 6 mg/ml MgO (experiment 3), had the strongest antibacterial activity against the Streptococcus mutans bacteria’s biofilm. In this condition, the bacterial survival rate was the lowest at 0.21 CFU/ml and under this optimal conditions could inhibit the activity of Streptococcus mutans bacteria at a rate of 0.09 CFU/ml.
{"title":"Investigation of antibacterial activity of new bionanocomposite based on polyvinyl alcohol(PVA)/arabic gum(AG)/MgO nanoparticles by Taguchi design for mouthwash application","authors":"Mohammad Salmani Mobarakeh, A. Moghadam","doi":"10.1680/jbibn.21.00035","DOIUrl":"https://doi.org/10.1680/jbibn.21.00035","url":null,"abstract":"Untreated dental caries is an important word challenge in human life. In this work, we synthesized polyvinyl alcohol-gum arabic-magnesium oxide nanoparticles new bionanocomposite and evaluated the antibacterial properties of its against Streptococcus mutans biofilm in vitro. For optimization of variables to have the maximum antibacterial property, L9 orthogonal array of Taguchi method was used for design of extraction conditions. The nanocomposites were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), X-ray energy diffraction (EDS), Thermogravimetric analysis (TGA) and transmission electron microscopy (TEM) tests. The FESEM images of nanocomposite inhibit that the nanoparticles are entirely surrounded with polymers chains of matrix and nanoparticles are deposited on the its walls, thus a layered nanocomposite is formed. The sheet width and size range of the nanocomposite was determined between 30-40 and 20-90 nm, respectively. The results showed that the synthesized nanocomposite with conditions of 1 mg/ml PVA, 3 mg/ml AG, and 6 mg/ml MgO (experiment 3), had the strongest antibacterial activity against the Streptococcus mutans bacteria’s biofilm. In this condition, the bacterial survival rate was the lowest at 0.21 CFU/ml and under this optimal conditions could inhibit the activity of Streptococcus mutans bacteria at a rate of 0.09 CFU/ml.","PeriodicalId":48847,"journal":{"name":"Bioinspired Biomimetic and Nanobiomaterials","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45673566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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