Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"Comparación del valor pronóstico de diferentes criterios de respuesta metabólica determinados por PET/TC en pacientes con cáncer de mama metastásico en tratamiento con inhibidores de CDK 4/6","authors":"H. Önner ,&nbsp;O.Ö. Eren ,&nbsp;M.K. Körez ,&nbsp;F. Yilmaz ,&nbsp;G.K. Gedik","doi":"10.1016/j.remn.2023.03.002","DOIUrl":"10.1016/j.remn.2023.03.002","url":null,"abstract":"<div><h3>Purpose</h3><p>This study evaluates the prognostic role of different [¹⁸F]FDG PET/CT metabolic response criteria in metastatic breast cancer (MBC) patients treated with cyclin-dependent kinase 4/6 inhibitors (CDK 4/6).</p></div><div><h3>Materials and methods</h3><p>We retrospectively evaluated the data of MBC patients treated with CDK 4/6 inhibitors who underwent an [¹⁸F]FDG PET/CT scan before starting and during treatment. [¹⁸F]FDG PET/CT response was assessed with the European Organization for Research and Treatment of Cancer, PET response criteria in solid tumors (PERCIST), and whole-body total lesion glycolysis (WBTLG) criteria. Fleiss kappa was computed to assess the agreement between metabolic response criteria. The endpoint of the study was progression-free survival (PFS). PFS data were analyzed by the Kaplan–Meier method and compared using the log-rank test.</p></div><div><h3>Results</h3><p>The study included 16 MBC patients who received CDK 4/6 inhibitors therapy. According to PERCIST, partial metabolic response (PMR) was found in seven patients, stable metabolic disease (SMD) in seven patients, and progressive metabolic disease (PMD) in two patients. According to the European Organization for Research and Treatment of Cancer, PMR was detected in eight patients, SMD in seven patients, and PMD in one patient. According to WBTLG, PMR was found in 10 patients, SMD in four patients, and PMD in two patients. There was a fair agreement between the three criteria. While progression was detected in seven of the patients during follow-up, no progression was detected in nine of them. Kaplan–Meier analysis revealed that the responders according to WBTLG showed significantly longer PFS than non-responders.</p></div><div><h3>Conclusion</h3><p>Treatment response according to WBTLG criteria during treatment appears to be associated with prolonged PFS in patients treated with CDK 4/6 inhibitors for MBC.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 318-323"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48844071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miositis osificante generalizada con intensa captación muscular difusa en la gammagrafía ósea de cuerpo entero de un niño de 13 años","authors":"S. Erfani ,&nbsp;M. Vahedi ,&nbsp;H. Mohammadzadeh ,&nbsp;A. Malek ,&nbsp;A. Aghaee","doi":"10.1016/j.remn.2023.05.001","DOIUrl":"10.1016/j.remn.2023.05.001","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 340-342"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47990518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rendimiento diagnóstico de diferentes protocolos de estrés cardiaco usados en imagen de perfusión miocárdica para el diagnóstico de enfermedad coronaria usando una cámara de cadmio-zinc-telurio con correlación con angiografía coronaria","authors":"M. Ochoa-Figueroa ,&nbsp;J. Frías-Rose ,&nbsp;E. Good ,&nbsp;V. Sánchez-Rodríguez ,&nbsp;A. Davidsson ,&nbsp;C. Pagonis","doi":"10.1016/j.remn.2022.01.001","DOIUrl":"10.1016/j.remn.2022.01.001","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the diagnostic performance of three different cardiac stress protocols for myocardial perfusion imaging (MPI) using a cadmium-zinc-telluride (CZT) camera with invasive coronary angiography (ICA) correlation for the diagnosis of coronary artery disease in a high risk population.</p></div><div><h3>Methods</h3><p>Retrospective study of 263 patients (96 women and 167 males, mean age 68 years) from which 119 patients performed a bicycle stress test (BST), 113 pharmacological stress test (PST) and 31 a combination of the two (CST) between September 2014 and December 2018. The patients then underwent myocardial perfusion imaging (MPI), followed by ICA and evaluated by means of quantitative angiography software, within six months after the MPI. The mean pre-test probability score for coronary disease according to the European Society of Cardiology criteria was 36% for the whole population. The MPI was performed in a dedicated CZT cardio camera (D-SPECT Spectrum Dynamics) with a two-day protocol, according to the European Association of Nuclear Medicine guidelines.</p></div><div><h3>Results</h3><p>No significant difference was observed between the three stress protocols in terms of diagnostic accuracy (BST 85%, PST 88% and CST 84%). The overall diagnostic accuracy of MPI to identify patients with any obstructive CAD at ICA was 86%, Sensitivity 93%, Specificity 54%, PPV 90% and NPV 63%.</p></div><div><h3>Conclusion</h3><p>The CZT D-SPECT camera achieves overall satisfactory results in the diagnosis of CAD, observing no significant differences in the diagnostic performance when the stress test was performed as a BST, PST or CST.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 281-288"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49109637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuantificación absoluta de la captación miocárdica de 99mTc-DPD en pacientes con amiloidosis cardiaca por depósitos de transtiretina (ATTR)","authors":"F. Sebastián Palacid,&nbsp;N. Álvarez Mena,&nbsp;R.C. Zambrano Infantino,&nbsp;M. García Aragón,&nbsp;M. Alonso Rodríguez,&nbsp;B. Pérez López,&nbsp;C. Gamazo Laherrán,&nbsp;M.J. González Soto,&nbsp;R. Ruano Pérez","doi":"10.1016/j.remn.2023.04.003","DOIUrl":"10.1016/j.remn.2023.04.003","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the diagnostic contribution of the absolute quantification of the myocardial deposit of ^99mTc-DPD in patients with cardiac amyloidosis due to transthyretin deposits (ATTR).</p></div><div><h3>Materials and methods</h3><p>SPECT/CT was performed on 41 patients with positive scintigraphic results for ATTR cardiac amyloidosis. The patients were divided into two groups (Perugini grades<!--> <!-->2 and<!--> <!-->3) and the SUVmax at the level of the bone and both ventricles and the percentage of dose calculated in these areas were calculated. Student's <em>t</em>-test was used to compare results and the area under the curve (AUC) was calculated to assess differential efficacy and establish discriminatory cut-off points between both groups of patients.</p></div><div><h3>Results</h3><p>Statistically significant differences were observed in all the study variables, with the exception of SUVmax bone. The differences with the greatest statistical power were observed in the variables SUVmax_RV and the percentage of dose in both ventricles (<em>P</em> <!-->&lt;<!--> <!-->.001). The cut-off point obtained for the variable SUVmax_LV was 8.620 (sensitivity 87.9% and specificity 100%; AUC: 0.966), while that of the variable SUVmax_RV was 6.195 (sensitivity 81.8% and specificity 100%; AUC: 0.955).</p></div><div><h3>Conclusions</h3><p>The absolute quantification of myocardial uptake of ^99mTc-DPD in the SPECT/CT images of patients with suspected cardiac amyloidosis due to transthyretin deposits represents a new diagnostic tool that allows an adequate classification of patients, according to the visual grading scale of Perugini.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 302-309"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47895856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esplenosis intrahepática visualizada en una gammagrafía con [99mTc]Tc-hematíes desnaturalizados","authors":"S. Bondia Bescós,&nbsp;J.J. Martin Marcuartu,&nbsp;M.T. Bajén Lázaro,&nbsp;J. Mora Salvadó,&nbsp;A. Benítez Segura,&nbsp;M. Cortés Romera","doi":"10.1016/j.remn.2023.01.005","DOIUrl":"https://doi.org/10.1016/j.remn.2023.01.005","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 336-337"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49837234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La relación entre los parámetros inmunohistoquímicos, la fibrosis de la médula ósea y la captación de 18F-FDG en la médula ósea en pacientes con mieloma múltiple sometidos a examen PET/TC","authors":"A.O. Oner ,&nbsp;Ç. Özdemir ,&nbsp;F. Yavaşoğlu ,&nbsp;Y. Şenol ,&nbsp;S. Naz Adsız","doi":"10.1016/j.remn.2023.01.011","DOIUrl":"https://doi.org/10.1016/j.remn.2023.01.011","url":null,"abstract":"<div><h3>Aim</h3><p>The aim of this study was to determine the power of the SUVmax value obtained from ¹⁸F-FDG PET/CT in multiple myeloma patients to be able to predict immunophenotype characteristics (CD20, CD44, CD56, CD117, and CD138 antigen expressions), bone marrow fibrosis, cyclin D1 oncogene, and M-protein subtypes which play a role in diagnosis-treatment and prognosis of the disease.</p></div><div><h3>Material and method</h3><p>The study included 54 patients with multiple myeloma who underwent PET/CT for initial staging and bone marrow biopsy. The relationship was examined in these patients between the SUVmax value measured from the iliac bone region and the immunohistochemical and bone marrow fibrosis data of the biopsy taken from the iliac bone. The Mann–Whitney U-test was used in the comparisons of dependent paired groups, and the Kruskal–Wallis H test in the comparisons of three or more groups.</p></div><div><h3>Results</h3><p>The median SUVmax value was 4.5 (1.9-15.6) in patients with CD117 antigen positivity, which was statistically significantly higher than the value in the patients with CD117 negativity (<em>P</em> <!-->=<!--> <!-->0.031). When patient grouping was made according to the reticulin level: We found that the median SUVmax value was 4.9 (3.0-14.8) in the group with increased fibrosis and 3.6 (1.6-15.6) in the group with low fibrosis. The median SUVmax was statistically significantly higher in the group with increased fibrosis compared to the group with low fibrosis (<em>P</em> <!-->=<!--> <!-->0.004). No statistically significant difference was determined in the comparisons of the SUVmax values when the patients were grouped according to the immunoglobulin heavy chain and light chain, CD20, CD44, CD56, and cyclin D1 characteristics (<em>P</em> <!-->&gt;<!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>In multiple myeloma patients who underwent PET/CT for initial staging, significant relationships were determined between FDG uptake in the bone marrow (SUVmax) and CD117 antigen and bone marrow fibrosis, which is an important prognostic factor. Higher SUVmax values were determined in the bone marrow of patients with increased fibrosis and CD117 positivity.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 5","pages":"Pages 289-295"},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49903082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarcadores pronósticos en el uso del radio-223 en pacientes con cáncer de próstata metastásico resistente a la castración","authors":"M. Vidal, R. Cárdenas-Perilla, A. Delgado, S. Morón, J.L. Londoño Blair, I. Vega, J.J. Correa Ochoa, J. Rojas","doi":"10.1016/j.remn.2023.06.004","DOIUrl":"https://doi.org/10.1016/j.remn.2023.06.004","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55118914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Una imagen PET amiloide estática del primer minuto (FMF) se correlaciona con [18F]FDG PET en pacientes con afasia progresiva primaria","authors":"A. Gómez-Grande ,&nbsp;A.P. Seiffert ,&nbsp;A. Villarejo-Galende ,&nbsp;M. González-Sánchez ,&nbsp;S. Llamas-Velasco ,&nbsp;H. Bueno ,&nbsp;E.J. Gómez ,&nbsp;M.J. Tabuenca ,&nbsp;P. Sánchez-González","doi":"10.1016/j.remn.2022.10.001","DOIUrl":"https://doi.org/10.1016/j.remn.2022.10.001","url":null,"abstract":"<div><h3>Objective</h3><p>To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with ¹⁸F-labeled amyloid-binding radiotracers and brain [¹⁸F]FDG PET in patients with primary progressive aphasia (PPA).</p></div><div><h3>Material and methods</h3><p>The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9<!--> <!-->nonfluent variant PPA, 4<!--> <!-->logopenic variant PPA, 1<!--> <!-->semantic variant PPA, 3<!--> <!-->unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [¹⁸F]FDG PET images and Pearson's correlation coefficients are calculated.</p></div><div><h3>Results</h3><p>SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of <em>r</em> <!-->=<!--> <!-->.94 ±<!--> <!-->.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.</p></div><div><h3>Conclusions</h3><p>The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 4","pages":"Pages 211-217"},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49797385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explorando la opinión de los especialistas españoles acerca de la utilidad de la radiómica en el área oncológica","authors":"P.M. Cárcamo Ibarra ,&nbsp;U.A. López González ,&nbsp;A. Esteban Hurtado ,&nbsp;N. Orrego Castro ,&nbsp;S. Diez Domingo","doi":"10.1016/j.remn.2023.02.001","DOIUrl":"10.1016/j.remn.2023.02.001","url":null,"abstract":"<div><h3>Aim</h3><p>To describe the knowledge and opinion of health professionals regarding the usefulness of radiomics in oncology.</p></div><div><h3>Methods</h3><p>A 12-question questionnaire (multiple-choice responses, Likert-type scale, and open response) was developed and sent to professionals related to diagnosis/treatment of oncological diseases (Oncology, Radiodiagnosis, Nuclear Medicine, Radiation Oncology, Hematology-Oncology, Radiophysics and Pathology). Participants were classified into two groups according to their level of training: attending physicians and residents.</p></div><div><h3>Results</h3><p>114 professionals completed the survey (54% residents, mostly from Nuclear Medicine and Radiodiagnostic specialties). Attending physicians obtained a better performance in the area pf knowledge compared to residents. Both groups of respondents agreed regarding the usefulness of radiomics to help make more accurate diagnoses and promoting the work of medical teams and the most frequent disadvantages were related to the lack of systematization in the acquisition of images and extraction of parameters, the need for the training of professionals and concern about the replacement of human work by technological tools.</p></div><div><h3>Conclusions</h3><p>Radiomics is a novel field and the most general aspects are known by health professionals. The professionals surveyed were optimistic about the benefits provided by radiomics and other types of tools. The main problem detected was the lack of systematization in its implementation. The replacement of professionals and job loss is a concern, albeit less prevalent, and may respond to a generational phenomenon.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 4","pages":"Pages 231-237"},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49127252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuantificación del efecto del movimiento vertical del paciente durante la gated-SPECT de perfusión miocárdica sobre los índices de perfusión y de función del ventrículo izquierdo","authors":"R. Ahmadi ,&nbsp;M. Qutbi","doi":"10.1016/j.remn.2023.02.003","DOIUrl":"https://doi.org/10.1016/j.remn.2023.02.003","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the effect of software-simulated «bouncing» motion on left ventricle (LV) perfusion and function indices concerning 3<!--> <!-->main determinants of motion (duration, magnitude and time) by evaluating the sole effect and interaction of these attributes in a statistical model.</p></div><div><h3>Methods</h3><p>Twenty-nine gated myocardial perfusion SPECT scans were selected for the study and then, «bounce» motion pattern was simulated manually regarding 3<!--> <!-->main attributes of motion including duration (short versus long), magnitude (2 versus 4 pixels) and time (early versus late), all in upward vertical direction. All SPECT images are reconstructed and filtered with an identical method (OSEM algorithm) and same parameters. Indices of LV myocardial perfusion and function are derived using QGS package of Cedars-Sinai software in original and simulated-motion images and are then compared with each other. Two- and 3-way repeated measure within-subjects ANOVA tests are conducted to evaluate the main effect of each variable or attribute and the interaction between them.</p></div><div><h3>Results</h3><p>Summed scores increase roughly exponentially from «no motion» to short bounce and then, to long bounce. In long 4-pixel bounce, perfusion defects are remarkable. All comparisons of defect extent and total perfusion deficit are statistically significant. Mean difference between short bounce motion patterns with «no motion» is small even in 4-pixel movements (almost 3% or lower). In contrast, mean difference between long bounce motion patterns with «no motion» is higher than 5%. Using a paired-sample <em>t</em> test, in all pairs, mean difference for ejection fraction is less than 4% which all are statistically significant. Value of end-diastolic volume and end-systolic volume are consistently decreased based on duration (from short to long) and magnitude (from 2 to 4 pixels). Using within-subjects ANOVAs, in long bounce, main effect of magnitude and interaction of magnitude and time, but not time solely, were statistically significant. In 2-pixel magnitude, none of variables and their interaction were significant, but in 4-pixel magnitude, EF showed statistical significance with duration.</p></div><div><h3>Conclusion</h3><p>The perfusion parameters are to a higher extent involved by motion particularly in long bounce with a 4-pixel displacement. In short bounce, the effect is negligible, and therefore, no need to repeat the scan. Parameters of function are much less vulnerable to be affected by motion. Thus, contrary to current recommendations, there may be less need to repeat the scan in short 2-pixel bounce.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"42 4","pages":"Pages 238-248"},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49825734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}