Pub Date : 2023-09-01DOI: 10.1016/j.remn.2023.04.003
F. Sebastián Palacid, N. Álvarez Mena, R.C. Zambrano Infantino, M. García Aragón, M. Alonso Rodríguez, B. Pérez López, C. Gamazo Laherrán, M.J. González Soto, R. Ruano Pérez
Purpose
To determine the diagnostic contribution of the absolute quantification of the myocardial deposit of 99mTc-DPD in patients with cardiac amyloidosis due to transthyretin deposits (ATTR).
Materials and methods
SPECT/CT was performed on 41 patients with positive scintigraphic results for ATTR cardiac amyloidosis. The patients were divided into two groups (Perugini grades 2 and 3) and the SUVmax at the level of the bone and both ventricles and the percentage of dose calculated in these areas were calculated. Student's t-test was used to compare results and the area under the curve (AUC) was calculated to assess differential efficacy and establish discriminatory cut-off points between both groups of patients.
Results
Statistically significant differences were observed in all the study variables, with the exception of SUVmax bone. The differences with the greatest statistical power were observed in the variables SUVmaxRV and the percentage of dose in both ventricles (P < .001). The cut-off point obtained for the variable SUVmaxLV was 8.620 (sensitivity 87.9% and specificity 100%; AUC: 0.966), while that of the variable SUVmaxRV was 6.195 (sensitivity 81.8% and specificity 100%; AUC: 0.955).
Conclusions
The absolute quantification of myocardial uptake of 99mTc-DPD in the SPECT/CT images of patients with suspected cardiac amyloidosis due to transthyretin deposits represents a new diagnostic tool that allows an adequate classification of patients, according to the visual grading scale of Perugini.
{"title":"Cuantificación absoluta de la captación miocárdica de 99mTc-DPD en pacientes con amiloidosis cardiaca por depósitos de transtiretina (ATTR)","authors":"F. Sebastián Palacid, N. Álvarez Mena, R.C. Zambrano Infantino, M. García Aragón, M. Alonso Rodríguez, B. Pérez López, C. Gamazo Laherrán, M.J. González Soto, R. Ruano Pérez","doi":"10.1016/j.remn.2023.04.003","DOIUrl":"10.1016/j.remn.2023.04.003","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the diagnostic contribution of the absolute quantification of the myocardial deposit of <sup>99m</sup>Tc-DPD in patients with cardiac amyloidosis due to transthyretin deposits (ATTR).</p></div><div><h3>Materials and methods</h3><p>SPECT/CT was performed on 41 patients with positive scintigraphic results for ATTR cardiac amyloidosis. The patients were divided into two groups (Perugini grades<!--> <!-->2 and<!--> <!-->3) and the SUVmax at the level of the bone and both ventricles and the percentage of dose calculated in these areas were calculated. Student's <em>t</em>-test was used to compare results and the area under the curve (AUC) was calculated to assess differential efficacy and establish discriminatory cut-off points between both groups of patients.</p></div><div><h3>Results</h3><p>Statistically significant differences were observed in all the study variables, with the exception of SUVmax bone. The differences with the greatest statistical power were observed in the variables SUVmax<sub>RV</sub> and the percentage of dose in both ventricles (<em>P</em> <!--><<!--> <!-->.001). The cut-off point obtained for the variable SUVmax<sub>LV</sub> was 8.620 (sensitivity 87.9% and specificity 100%; AUC: 0.966), while that of the variable SUVmax<sub>RV</sub> was 6.195 (sensitivity 81.8% and specificity 100%; AUC: 0.955).</p></div><div><h3>Conclusions</h3><p>The absolute quantification of myocardial uptake of <sup>99m</sup>Tc-DPD in the SPECT/CT images of patients with suspected cardiac amyloidosis due to transthyretin deposits represents a new diagnostic tool that allows an adequate classification of patients, according to the visual grading scale of Perugini.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47895856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.remn.2023.01.005
S. Bondia Bescós, J.J. Martin Marcuartu, M.T. Bajén Lázaro, J. Mora Salvadó, A. Benítez Segura, M. Cortés Romera
{"title":"Esplenosis intrahepática visualizada en una gammagrafía con [99mTc]Tc-hematíes desnaturalizados","authors":"S. Bondia Bescós, J.J. Martin Marcuartu, M.T. Bajén Lázaro, J. Mora Salvadó, A. Benítez Segura, M. Cortés Romera","doi":"10.1016/j.remn.2023.01.005","DOIUrl":"https://doi.org/10.1016/j.remn.2023.01.005","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49837234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.remn.2023.01.011
A.O. Oner , Ç. Özdemir , F. Yavaşoğlu , Y. Şenol , S. Naz Adsız
Aim
The aim of this study was to determine the power of the SUVmax value obtained from 18F-FDG PET/CT in multiple myeloma patients to be able to predict immunophenotype characteristics (CD20, CD44, CD56, CD117, and CD138 antigen expressions), bone marrow fibrosis, cyclin D1 oncogene, and M-protein subtypes which play a role in diagnosis-treatment and prognosis of the disease.
Material and method
The study included 54 patients with multiple myeloma who underwent PET/CT for initial staging and bone marrow biopsy. The relationship was examined in these patients between the SUVmax value measured from the iliac bone region and the immunohistochemical and bone marrow fibrosis data of the biopsy taken from the iliac bone. The Mann–Whitney U-test was used in the comparisons of dependent paired groups, and the Kruskal–Wallis H test in the comparisons of three or more groups.
Results
The median SUVmax value was 4.5 (1.9-15.6) in patients with CD117 antigen positivity, which was statistically significantly higher than the value in the patients with CD117 negativity (P = 0.031). When patient grouping was made according to the reticulin level: We found that the median SUVmax value was 4.9 (3.0-14.8) in the group with increased fibrosis and 3.6 (1.6-15.6) in the group with low fibrosis. The median SUVmax was statistically significantly higher in the group with increased fibrosis compared to the group with low fibrosis (P = 0.004). No statistically significant difference was determined in the comparisons of the SUVmax values when the patients were grouped according to the immunoglobulin heavy chain and light chain, CD20, CD44, CD56, and cyclin D1 characteristics (P > 0.05).
Conclusion
In multiple myeloma patients who underwent PET/CT for initial staging, significant relationships were determined between FDG uptake in the bone marrow (SUVmax) and CD117 antigen and bone marrow fibrosis, which is an important prognostic factor. Higher SUVmax values were determined in the bone marrow of patients with increased fibrosis and CD117 positivity.
{"title":"La relación entre los parámetros inmunohistoquímicos, la fibrosis de la médula ósea y la captación de 18F-FDG en la médula ósea en pacientes con mieloma múltiple sometidos a examen PET/TC","authors":"A.O. Oner , Ç. Özdemir , F. Yavaşoğlu , Y. Şenol , S. Naz Adsız","doi":"10.1016/j.remn.2023.01.011","DOIUrl":"https://doi.org/10.1016/j.remn.2023.01.011","url":null,"abstract":"<div><h3>Aim</h3><p>The aim of this study was to determine the power of the SUVmax value obtained from <sup>18</sup>F-FDG PET/CT in multiple myeloma patients to be able to predict immunophenotype characteristics (CD20, CD44, CD56, CD117, and CD138 antigen expressions), bone marrow fibrosis, cyclin D1 oncogene, and M-protein subtypes which play a role in diagnosis-treatment and prognosis of the disease.</p></div><div><h3>Material and method</h3><p>The study included 54 patients with multiple myeloma who underwent PET/CT for initial staging and bone marrow biopsy. The relationship was examined in these patients between the SUVmax value measured from the iliac bone region and the immunohistochemical and bone marrow fibrosis data of the biopsy taken from the iliac bone. The Mann–Whitney U-test was used in the comparisons of dependent paired groups, and the Kruskal–Wallis H test in the comparisons of three or more groups.</p></div><div><h3>Results</h3><p>The median SUVmax value was 4.5 (1.9-15.6) in patients with CD117 antigen positivity, which was statistically significantly higher than the value in the patients with CD117 negativity (<em>P</em> <!-->=<!--> <!-->0.031). When patient grouping was made according to the reticulin level: We found that the median SUVmax value was 4.9 (3.0-14.8) in the group with increased fibrosis and 3.6 (1.6-15.6) in the group with low fibrosis. The median SUVmax was statistically significantly higher in the group with increased fibrosis compared to the group with low fibrosis (<em>P</em> <!-->=<!--> <!-->0.004). No statistically significant difference was determined in the comparisons of the SUVmax values when the patients were grouped according to the immunoglobulin heavy chain and light chain, CD20, CD44, CD56, and cyclin D1 characteristics (<em>P</em> <!-->><!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>In multiple myeloma patients who underwent PET/CT for initial staging, significant relationships were determined between FDG uptake in the bone marrow (SUVmax) and CD117 antigen and bone marrow fibrosis, which is an important prognostic factor. Higher SUVmax values were determined in the bone marrow of patients with increased fibrosis and CD117 positivity.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49903082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.1016/j.remn.2023.06.004
M. Vidal, R. Cárdenas-Perilla, A. Delgado, S. Morón, J.L. Londoño Blair, I. Vega, J.J. Correa Ochoa, J. Rojas
{"title":"Biomarcadores pronósticos en el uso del radio-223 en pacientes con cáncer de próstata metastásico resistente a la castración","authors":"M. Vidal, R. Cárdenas-Perilla, A. Delgado, S. Morón, J.L. Londoño Blair, I. Vega, J.J. Correa Ochoa, J. Rojas","doi":"10.1016/j.remn.2023.06.004","DOIUrl":"https://doi.org/10.1016/j.remn.2023.06.004","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55118914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.remn.2022.10.001
A. Gómez-Grande , A.P. Seiffert , A. Villarejo-Galende , M. González-Sánchez , S. Llamas-Velasco , H. Bueno , E.J. Gómez , M.J. Tabuenca , P. Sánchez-González
Objective
To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with 18F-labeled amyloid-binding radiotracers and brain [18F]FDG PET in patients with primary progressive aphasia (PPA).
Material and methods
The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9 nonfluent variant PPA, 4 logopenic variant PPA, 1 semantic variant PPA, 3 unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [18F]FDG PET images and Pearson's correlation coefficients are calculated.
Results
SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of r = .94 ± .06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.
Conclusions
The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.
{"title":"Una imagen PET amiloide estática del primer minuto (FMF) se correlaciona con [18F]FDG PET en pacientes con afasia progresiva primaria","authors":"A. Gómez-Grande , A.P. Seiffert , A. Villarejo-Galende , M. González-Sánchez , S. Llamas-Velasco , H. Bueno , E.J. Gómez , M.J. Tabuenca , P. Sánchez-González","doi":"10.1016/j.remn.2022.10.001","DOIUrl":"https://doi.org/10.1016/j.remn.2022.10.001","url":null,"abstract":"<div><h3>Objective</h3><p>To study the correlation between a static PET image of the first-minute-frame (FMF) acquired with <sup>18</sup>F-labeled amyloid-binding radiotracers and brain [<sup>18</sup>F]FDG PET in patients with primary progressive aphasia (PPA).</p></div><div><h3>Material and methods</h3><p>The study cohort includes 17 patients diagnosed with PPA with the following distribution: 9<!--> <!-->nonfluent variant PPA, 4<!--> <!-->logopenic variant PPA, 1<!--> <!-->semantic variant PPA, 3<!--> <!-->unclassifiable PPA. Regional SUVRs are extracted from FMFs and their corresponding [<sup>18</sup>F]FDG PET images and Pearson's correlation coefficients are calculated.</p></div><div><h3>Results</h3><p>SUVRs of both images show similar patterns of regional cerebral alterations. Intrapatient correlation analyses result in a mean coefficient of <em>r</em> <!-->=<!--> <!-->.94 ±<!--> <!-->.06. Regional interpatient correlation coefficients of the study cohort are greater than 0.81. Radiotracer-specific and variant-specific subcohorts show no difference in the similarity between the images.</p></div><div><h3>Conclusions</h3><p>The static FMF could be a valid alternative to dynamic early-phase amyloid PET proposed in the literature, and a neurodegeneration biomarker for the diagnosis and classification of PPA in amyloid PET studies.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49797385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.remn.2023.02.001
P.M. Cárcamo Ibarra , U.A. López González , A. Esteban Hurtado , N. Orrego Castro , S. Diez Domingo
Aim
To describe the knowledge and opinion of health professionals regarding the usefulness of radiomics in oncology.
Methods
A 12-question questionnaire (multiple-choice responses, Likert-type scale, and open response) was developed and sent to professionals related to diagnosis/treatment of oncological diseases (Oncology, Radiodiagnosis, Nuclear Medicine, Radiation Oncology, Hematology-Oncology, Radiophysics and Pathology). Participants were classified into two groups according to their level of training: attending physicians and residents.
Results
114 professionals completed the survey (54% residents, mostly from Nuclear Medicine and Radiodiagnostic specialties). Attending physicians obtained a better performance in the area pf knowledge compared to residents. Both groups of respondents agreed regarding the usefulness of radiomics to help make more accurate diagnoses and promoting the work of medical teams and the most frequent disadvantages were related to the lack of systematization in the acquisition of images and extraction of parameters, the need for the training of professionals and concern about the replacement of human work by technological tools.
Conclusions
Radiomics is a novel field and the most general aspects are known by health professionals. The professionals surveyed were optimistic about the benefits provided by radiomics and other types of tools. The main problem detected was the lack of systematization in its implementation. The replacement of professionals and job loss is a concern, albeit less prevalent, and may respond to a generational phenomenon.
{"title":"Explorando la opinión de los especialistas españoles acerca de la utilidad de la radiómica en el área oncológica","authors":"P.M. Cárcamo Ibarra , U.A. López González , A. Esteban Hurtado , N. Orrego Castro , S. Diez Domingo","doi":"10.1016/j.remn.2023.02.001","DOIUrl":"10.1016/j.remn.2023.02.001","url":null,"abstract":"<div><h3>Aim</h3><p>To describe the knowledge and opinion of health professionals regarding the usefulness of radiomics in oncology.</p></div><div><h3>Methods</h3><p>A 12-question questionnaire (multiple-choice responses, Likert-type scale, and open response) was developed and sent to professionals related to diagnosis/treatment of oncological diseases (Oncology, Radiodiagnosis, Nuclear Medicine, Radiation Oncology, Hematology-Oncology, Radiophysics and Pathology). Participants were classified into two groups according to their level of training: attending physicians and residents.</p></div><div><h3>Results</h3><p>114 professionals completed the survey (54% residents, mostly from Nuclear Medicine and Radiodiagnostic specialties). Attending physicians obtained a better performance in the area pf knowledge compared to residents. Both groups of respondents agreed regarding the usefulness of radiomics to help make more accurate diagnoses and promoting the work of medical teams and the most frequent disadvantages were related to the lack of systematization in the acquisition of images and extraction of parameters, the need for the training of professionals and concern about the replacement of human work by technological tools.</p></div><div><h3>Conclusions</h3><p>Radiomics is a novel field and the most general aspects are known by health professionals. The professionals surveyed were optimistic about the benefits provided by radiomics and other types of tools. The main problem detected was the lack of systematization in its implementation. The replacement of professionals and job loss is a concern, albeit less prevalent, and may respond to a generational phenomenon.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49127252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.remn.2023.02.003
R. Ahmadi , M. Qutbi
Objective
To assess the effect of software-simulated «bouncing» motion on left ventricle (LV) perfusion and function indices concerning 3 main determinants of motion (duration, magnitude and time) by evaluating the sole effect and interaction of these attributes in a statistical model.
Methods
Twenty-nine gated myocardial perfusion SPECT scans were selected for the study and then, «bounce» motion pattern was simulated manually regarding 3 main attributes of motion including duration (short versus long), magnitude (2 versus 4 pixels) and time (early versus late), all in upward vertical direction. All SPECT images are reconstructed and filtered with an identical method (OSEM algorithm) and same parameters. Indices of LV myocardial perfusion and function are derived using QGS package of Cedars-Sinai software in original and simulated-motion images and are then compared with each other. Two- and 3-way repeated measure within-subjects ANOVA tests are conducted to evaluate the main effect of each variable or attribute and the interaction between them.
Results
Summed scores increase roughly exponentially from «no motion» to short bounce and then, to long bounce. In long 4-pixel bounce, perfusion defects are remarkable. All comparisons of defect extent and total perfusion deficit are statistically significant. Mean difference between short bounce motion patterns with «no motion» is small even in 4-pixel movements (almost 3% or lower). In contrast, mean difference between long bounce motion patterns with «no motion» is higher than 5%. Using a paired-sample t test, in all pairs, mean difference for ejection fraction is less than 4% which all are statistically significant. Value of end-diastolic volume and end-systolic volume are consistently decreased based on duration (from short to long) and magnitude (from 2 to 4 pixels). Using within-subjects ANOVAs, in long bounce, main effect of magnitude and interaction of magnitude and time, but not time solely, were statistically significant. In 2-pixel magnitude, none of variables and their interaction were significant, but in 4-pixel magnitude, EF showed statistical significance with duration.
Conclusion
The perfusion parameters are to a higher extent involved by motion particularly in long bounce with a 4-pixel displacement. In short bounce, the effect is negligible, and therefore, no need to repeat the scan. Parameters of function are much less vulnerable to be affected by motion. Thus, contrary to current recommendations, there may be less need to repeat the scan in short 2-pixel bounce.
{"title":"Cuantificación del efecto del movimiento vertical del paciente durante la gated-SPECT de perfusión miocárdica sobre los índices de perfusión y de función del ventrículo izquierdo","authors":"R. Ahmadi , M. Qutbi","doi":"10.1016/j.remn.2023.02.003","DOIUrl":"https://doi.org/10.1016/j.remn.2023.02.003","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the effect of software-simulated «bouncing» motion on left ventricle (LV) perfusion and function indices concerning 3<!--> <!-->main determinants of motion (duration, magnitude and time) by evaluating the sole effect and interaction of these attributes in a statistical model.</p></div><div><h3>Methods</h3><p>Twenty-nine gated myocardial perfusion SPECT scans were selected for the study and then, «bounce» motion pattern was simulated manually regarding 3<!--> <!-->main attributes of motion including duration (short versus long), magnitude (2 versus 4 pixels) and time (early versus late), all in upward vertical direction. All SPECT images are reconstructed and filtered with an identical method (OSEM algorithm) and same parameters. Indices of LV myocardial perfusion and function are derived using QGS package of Cedars-Sinai software in original and simulated-motion images and are then compared with each other. Two- and 3-way repeated measure within-subjects ANOVA tests are conducted to evaluate the main effect of each variable or attribute and the interaction between them.</p></div><div><h3>Results</h3><p>Summed scores increase roughly exponentially from «no motion» to short bounce and then, to long bounce. In long 4-pixel bounce, perfusion defects are remarkable. All comparisons of defect extent and total perfusion deficit are statistically significant. Mean difference between short bounce motion patterns with «no motion» is small even in 4-pixel movements (almost 3% or lower). In contrast, mean difference between long bounce motion patterns with «no motion» is higher than 5%. Using a paired-sample <em>t</em> test, in all pairs, mean difference for ejection fraction is less than 4% which all are statistically significant. Value of end-diastolic volume and end-systolic volume are consistently decreased based on duration (from short to long) and magnitude (from 2 to 4 pixels). Using within-subjects ANOVAs, in long bounce, main effect of magnitude and interaction of magnitude and time, but not time solely, were statistically significant. In 2-pixel magnitude, none of variables and their interaction were significant, but in 4-pixel magnitude, EF showed statistical significance with duration.</p></div><div><h3>Conclusion</h3><p>The perfusion parameters are to a higher extent involved by motion particularly in long bounce with a 4-pixel displacement. In short bounce, the effect is negligible, and therefore, no need to repeat the scan. Parameters of function are much less vulnerable to be affected by motion. Thus, contrary to current recommendations, there may be less need to repeat the scan in short 2-pixel bounce.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49825734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.remn.2023.04.005
P. Jiménez-Granero , J.I. Rayo-Madrid , J.R. Infante-de-la-Torre , J. Serrano-Vicente , A. Martínez-Esteve , A. Baena-García , A. Utrera-Costero , R. Juárez-Vela
Objective
To identify the frequency of errors in the informed consent documents in radioguided surgery in a third level hospital and to detect possible causes or factors associated with a greater risk of error.
Material and method
The informed consents of a total of 369 radioguided surgery interventions, completed by the Nuclear Medicine and General Surgery services, were analyzed, as well as their degree of completion and its correlation with responsible physicians, type of pathology and intervention, waiting time and completion of the consent of the other specialty.
Results
Errors were identified in 22 consent forms for Nuclear Medicine and 71 consent forms for General Surgery. The most common error was the absence of identification of the responsible physician (17 in Nuclear Medicine, 51 in General Surgery), and the second most common was the absence of a document (2 in Nuclear Medicine, 20 in General Surgery). There were significant differences in the errors made depending on the doctor in charge, without finding a significant correlation with the other variables.
Conclusions
The responsible physicians were the main factor associated with a greater risk of error in the completion of informed consent. New studies would be recommended to analyze causal factors and possible interventions to minimize errors.
{"title":"Cumplimentación del consentimiento informado en cirugía radioguiada por los servicios de Cirugía General y Medicina Nuclear de una unidad de cirugía radioguiada","authors":"P. Jiménez-Granero , J.I. Rayo-Madrid , J.R. Infante-de-la-Torre , J. Serrano-Vicente , A. Martínez-Esteve , A. Baena-García , A. Utrera-Costero , R. Juárez-Vela","doi":"10.1016/j.remn.2023.04.005","DOIUrl":"10.1016/j.remn.2023.04.005","url":null,"abstract":"<div><h3>Objective</h3><p>To identify the frequency of errors in the informed consent documents in radioguided surgery in a third level hospital and to detect possible causes or factors associated with a greater risk of error.</p></div><div><h3>Material and method</h3><p>The informed consents of a total of 369 radioguided surgery interventions, completed by the Nuclear Medicine and General Surgery services, were analyzed, as well as their degree of completion and its correlation with responsible physicians, type of pathology and intervention, waiting time and completion of the consent of the other specialty.</p></div><div><h3>Results</h3><p>Errors were identified in 22 consent forms for Nuclear Medicine and 71 consent forms for General Surgery. The most common error was the absence of identification of the responsible physician (17 in Nuclear Medicine, 51 in General Surgery), and the second most common was the absence of a document (2 in Nuclear Medicine, 20 in General Surgery). There were significant differences in the errors made depending on the doctor in charge, without finding a significant correlation with the other variables.</p></div><div><h3>Conclusions</h3><p>The responsible physicians were the main factor associated with a greater risk of error in the completion of informed consent. New studies would be recommended to analyze causal factors and possible interventions to minimize errors.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48487643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.remn.2023.01.001
S. Gülbahar Ateş , G. Bilir Dilek , G. Uçmak
Purpose
This retrospective study aimed to investigate the value of texture features of primary tumors in pretreatment18F-FDG PET/CT in the prediction of response to treatment, progression, and overall survival in patients with rectal cancer who underwent surgery after neoadjuvant therapy (NAT).
Methods
Patients with rectal cancer who had pretreatment18F-FDG PET/CT, and underwent surgery after NAT were included in this study. Clinicopathologic features, date of last follow-up, progression, and death were recorded. Textural and conventional PET parameters (maximum standardized uptake value-SUVmax, metabolic tumor volume-MTV, total lesion glycolysis-TLG) were obtained from PET/CT images using LifeX program. Parameters were grouped using Youden index in ROC analysis. Factors predicting the pathological response to treatment, progression, and overall survival were determined using logistic regression and Cox regression analyses.
Results
Forty-four patients (26(59%) male, 18 (41%) female; 60.1 ± 11.4 years) with rectal cancer were included in this study. The numbers of patients with responders and non-responders to NAT were15(34.9%) and 28(65.1%), respectively. One patient’ pathology report did not contain the response status to NAT. The median of follow-up duration was 29.9 months. 9(20.5%) showed disease progression, and 8(18.2%) died during the follow-up period. Difference entropy GLCM and correlation GLCM parameters were found as independent predictors for response to NAT. The positivity of surgical margin, intensity interquartile range CONV and AUC-CSHDISC texture parameters were independent predictors of progression, while normalized inverse difference GLCM and LZLGEGLZLM parameters were independent predictorsof mortality.
Conclusion
The texture parameters obtained from pretreatment18F-FDG PET/CT have presented a more robust predictive value than conventional parameters in patients with rectal cancer who underwent surgery after NAT.
{"title":"Heterogeneidad del tumor primario en la18F-FDG PET/TC pretratamiento para predecir el pronóstico en pacientes con cáncer de recto sometidos a cirugía tras terapia neoadyuvante","authors":"S. Gülbahar Ateş , G. Bilir Dilek , G. Uçmak","doi":"10.1016/j.remn.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.remn.2023.01.001","url":null,"abstract":"<div><h3>Purpose</h3><p>This retrospective study aimed to investigate the value of texture features of primary tumors in pretreatment<sup>18</sup>F-FDG PET/CT in the prediction of response to treatment, progression, and overall survival in patients with rectal cancer who underwent surgery after neoadjuvant therapy (NAT).</p></div><div><h3>Methods</h3><p>Patients with rectal cancer who had pretreatment<sup>18</sup>F-FDG PET/CT, and underwent surgery after NAT were included in this study. Clinicopathologic features, date of last follow-up, progression, and death were recorded. Textural and conventional PET parameters (maximum standardized uptake value-SUVmax, metabolic tumor volume-MTV, total lesion glycolysis-TLG) were obtained from PET/CT images using LifeX program. Parameters were grouped using Youden index in ROC analysis. Factors predicting the pathological response to treatment, progression, and overall survival were determined using logistic regression and Cox regression analyses.</p></div><div><h3>Results</h3><p>Forty-four patients (26(59%) male, 18 (41%) female; 60.1 ± 11.4 years) with rectal cancer were included in this study. The numbers of patients with responders and non-responders to NAT were15(34.9%) and 28(65.1%), respectively. One patient’ pathology report did not contain the response status to NAT. The median of follow-up duration was 29.9 months. 9(20.5%) showed disease progression, and 8(18.2%) died during the follow-up period. Difference entropy GLCM and correlation GLCM parameters were found as independent predictors for response to NAT. The positivity of surgical margin, intensity interquartile range CONV and AUC-CSHDISC texture parameters were independent predictors of progression, while normalized inverse difference GLCM and LZLGEGLZLM parameters were independent predictorsof mortality.</p></div><div><h3>Conclusion</h3><p>The texture parameters obtained from pretreatment<sup>18</sup>F-FDG PET/CT have presented a more robust predictive value than conventional parameters in patients with rectal cancer who underwent surgery after NAT.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49797386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.remn.2022.02.005
A. Moreno-Ballesteros , R. González-Cámpora , S. Navarro-Vázquez , J. Arce-Durán , B. González-Gaggero
{"title":"Hallazgo inesperado de gangrena de Fournier en la PET/TC con 18FDG de un paciente con adenocarcinoma de pulmón metastásico","authors":"A. Moreno-Ballesteros , R. González-Cámpora , S. Navarro-Vázquez , J. Arce-Durán , B. González-Gaggero","doi":"10.1016/j.remn.2022.02.005","DOIUrl":"https://doi.org/10.1016/j.remn.2022.02.005","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49825732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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