Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

英文中文

Importancia pronóstica de las distancias normalizadas entre el punto de captación máxima estandarizado del radiotrazador y el centro tumoral en la PET/TC con 18F-FDG en el carcinoma de células escamosas de cabeza y cuello 在头颈部鳞状细胞癌中，使用18F-FDG的PET/ CT中，标准放射示踪剂的最大采集点与肿瘤中心之间标准化距离的预测重要性

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2025.500103

S.-P. Hong , S.M. Lee , I.D. Yoo , I.Y. Jo , Y.K. Won , M.-S. Kim , H.J. Choi , J. Won Lee , S.J. Jang

Objective

The maximum ¹⁸F-FDG uptake of a cancer lesion has been found to relocate from the center to the periphery during progression. This behavior proposes that the normalized distances from the hotspot of radiotracer uptake to the tumor centroid (NHOC) and to the tumor perimeter (NHOP) could serve as novel geometric PET parameters indicative of tumor aggressiveness. This study aimed to explore the prognostic relevance of NHOC and NHOP in ¹⁸F-FDG PET/CT for predicting the response to concurrent chemoradiotherapy (CCRT) and progression-free survival (PFS) in patients with head and neck squamous cell carcinoma.

Materials and methods

We retrospectively reviewed 116 head and neck squamous cell carcinoma patients who received CCRT and were assessed with pre-treatment (PET1) and 3 months post-treatment PET/CT (PET2). Along with conventional PET parameters, NHOC and NHOP for primary tumors on PET1 and the percent changes in NHOC and NHOP between PET1 and PET2 were measured.

Results

Of all the PET1 parameters assessed, NHOC was the most effective in predicting the CCRT response, achieving an area under the receiver operating characteristic curve of 0.645. In multivariate logistic regression and survival analysis, NHOC identified as an independent predictor for both complete metabolic response (p = 0.028) and PFS (p = 0.006). In a subgroup of 46 patients exhibiting residual primary tumors on PET2, both the percent changes in NHOC (p = 0.048) and NHOP (p = 0.041) were significantly associated with PFS.

Conclusions

NHOC and the percent changes in NHOC and NHOP following CCRT may serve as effective ¹⁸F-FDG PET/CT parameters for predicting clinical outcomes in head and neck squamous cell carcinoma patients.

目的发现在肿瘤进展过程中，18F-FDG的最大摄取从中心向外周转移。这种行为表明，从放射性示踪剂摄取热点到肿瘤质心（NHOC）和肿瘤周长（NHOP）的归一化距离可以作为指示肿瘤侵袭性的新型几何PET参数。本研究旨在探讨NHOC和NHOP在18F-FDG PET/CT中预测头颈部鳞状细胞癌患者同步放化疗（CCRT）反应和无进展生存期（PFS）的预后相关性。材料与方法我们回顾性分析116例接受CCRT治疗的头颈部鳞状细胞癌患者，并对治疗前（PET1）和治疗后3个月的PET/CT （PET2）进行评估。在常规PET参数的基础上，测定PET1上原发肿瘤的NHOC和NHOP，以及PET1和PET2之间NHOC和NHOP的变化百分比。结果在所有评估的PET1参数中，NHOC预测CCRT反应最有效，其在受试者工作特征曲线下的面积为0.645。在多变量logistic回归和生存分析中，NHOC被确定为完全代谢反应（p = 0.028）和PFS （p = 0.006）的独立预测因子。在一个由46名在PET2上显示残留原发肿瘤的患者组成的亚组中，NHOC （p = 0.048）和NHOP （p = 0.041）的百分比变化与PFS显著相关。结论CCRT后snhoc及NHOC和NHOP百分比变化可作为预测头颈部鳞状细胞癌患者临床预后的有效18F-FDG PET/CT参数。

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引用次数: 0

Síndrome de activación macrofágica en un paciente pediátrico: hallazgos en PET/TC con 18F-FDG 儿科患者巨噬细胞活化综合征：PET/ CT与18F-FDG的发现

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2025.500183

J.P. Suárez Fernández, M.L. Domínguez Grande, C. Vigil Díaz, B. Fernández Llana, N. Martín Fernández, F.M. González García

引用次数: 0

Utilidad de la PET/TC con [18F]FDG más allá de la estadificación: importancia pronóstica de la sarcopenia y del metabolismo del tejido adiposo en el carcinoma esofágico PET/ CT与[18F]FDG的应用超越了确定阶段：在食管癌中减少结节和脂肪组织代谢的预后重要性

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2024.500090

M.N. Acar Tayyar , M. Öner Tamam , G. Buğrahan Babacan , M. Can Şahin , H. Özçevik , N. Gürdal , K. Atakır

Aim

This study aimed to investigate the relationship between PET and CT parameters and sarcopenia, adipose tissue, and tumor metabolism in esophageal carcinoma (EC) and its impact on survival in EC.

Method

Our study included 122 EC patients who underwent PET/CT for staging. Muscle and adipose tissue characteristics were evaluated, including lumbar (L3) and cervical (C3) muscle areas, psoas major (PM) and sternocleidomastoid muscle (SCM) parameters, and PET parameters for visceral and subcutaneous adipose tissue (SAT). Sarcopenia was determined using CT images, with a threshold for muscle tissue at the L3 vertebral level, and its impact on overall survival (OS) was investigated.

Results

Sarcopenia was detected in 48 patients. SULmax in the primary tumor (PT) was significantly higher in sarcopenic patients (SP). The frequency of distant metastasis was higher in SP and OS was significantly lower. In the locally advanced stage, sarcopenia status decreased survival. L3, PM, C3, and SCM muscle areas were highly correlated. Subcutaneous adipose tissue SUVmax was significantly increased in SP and those with distant metastasis. Univariate analysis identified PT SULmax, PT SUVmean, PT TLG, lymph node and distant metastasis, SAT SUVmax, and sarcopenia as poor prognostic factors, while multivariate analysis confirmed BMI, distant metastasis, PT SUVmean, PT TLG as independent predictors of OS.

Conclusion

This study demonstrated that sarcopenia, linked to reduced survival, correlates with primary tumor SULmax, distant metastasis, and subcutaneous tissue PET parameters, exerting a notable impact on survival, particularly in locally advanced stages. Attenuation-corrected CT can be used instead of diagnostic CT, and sarcopenia can be diagnosed using not only L3 but also C3 slices.

目的探讨PET、CT参数与食管癌（EC）肌肉减少症、脂肪组织及肿瘤代谢的关系及其对生存的影响。方法122例EC患者行PET/CT分期。评估肌肉和脂肪组织特征，包括腰椎（L3）和颈椎（C3）肌肉区域、腰肌（PM）和胸锁乳突肌（SCM）参数，以及内脏和皮下脂肪组织（SAT）的PET参数。使用CT图像确定肌肉减少症，并在L3椎体水平设置肌肉组织阈值，并研究其对总生存期（OS）的影响。结果48例患者出现肌肉减少症。原发性肿瘤患者（PT）的SULmax明显高于肌肉减少症患者（SP）。SP的远处转移频率较高，OS的远处转移频率明显较低。在局部晚期，肌少症状态降低了生存率。L3、PM、C3和SCM肌区高度相关。皮下脂肪组织SUVmax在SP和远处转移患者中显著增加。单因素分析发现PT SULmax、PT SUVmean、PT TLG、淋巴结和远处转移、SAT SUVmax和肌肉减少症是不良预后因素，多因素分析证实BMI、远处转移、PT SUVmean、PT TLG是OS的独立预测因素。本研究表明，肌肉减少症与生存率降低有关，与原发肿瘤SULmax、远处转移和皮下组织PET参数相关，对生存率有显著影响，特别是在局部晚期。可以使用衰减校正CT代替诊断性CT，不仅可以使用L3片，还可以使用C3片诊断肌肉减少症。

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引用次数: 0

PET/TC con 18F-FDG de doble tiempo en un caso de linfoma extranodal primario hepático de zona marginal del tejido linfoide asociado a mucosa 在粘膜相关淋巴组织边缘区原发性肝样外淋巴瘤病例中，PET/TC加18F-FDG两次

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2025.500105

R. Yang, Z. Zheng, Y. Lin, H. Shi

引用次数: 0

Evaluación del angiosarcoma cardíaco mediante [18F]FDG PET/TC 使用[18F]FDG PET/TC评估心脏血管肉瘤

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2025.500131

B. Hervás-Sanz , N. Ruiz-Roig , L. Rodríguez-Bel , L.M. Gràcia-Sánchez , M. Cortés-Romera , P.C. Notta

引用次数: 0

PET/TC con [18F]FDG en el diagnóstico y evaluación de respuesta al tratamiento en un paciente con sarcoidosis sistémica PET/ CT与[18F]FDG在全身性结节病患者治疗反应的诊断和评估

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2025.500135

J.P. Suárez Fernández, S. Naranjo Sancho, M.L. Domínguez Grande, C. Vigil Díaz, N. Martín Fernández, F.M. González García

引用次数: 0

El efecto sinérgico de la resonancia magnética multiparamétrica y la imagen PET/TC con [18F]PSMA-1007 en el estudio de la recidiva del adenocarcinoma prostático localmente avanzado 多参数磁共振成像和PET/ CT成像与[18F]PSMA-1007在局部晚期前列腺腺癌复发研究中的协同作用

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2025.500104

D. Schmitt , L. Schimmöller , E. Novruzov , J. Kirchner , M. Boschheidgen , E. Mamlins , C. Antke , Y. Mori , G. Antoch , F.L. Giesel

引用次数: 0

Actualización del procedimiento y guía de interpretación del estudio PET cerebral con 18F-FDG 使用18F-FDG进行脑PET研究的程序更新和解释指南

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2025.500159

C. Vigil Díaz , P. Paredes Rodríguez , A. Perissinotti , E. Fernando Guillén , D.A. López Mora , J.A. Lojo Ramírez , P. Aguiar Fernández , V. Camacho Martí , M. Nieves Cabrera-Martín , por el grupo de Trabajo de Neuroimagen de la SEMNIM

The increase in the prevalence of dementia in our clinical setting poses a diagnostic challenge for the Nuclear Medicine specialist. The aim of this study is to review the modifications in the procedure and to describe the usefulness of the use of brain PET with ¹⁸F-FDG in different clinical indications, both classic and emerging ones. The SEMNIM Neuroimaging working group has considered appropriate to update the procedures available in Spanish, in order to optimize the quality of this technique and the interpretation of its findings, both for the specialist in Nuclear Medicine and the rest of the professionals involved in the diagnosis and treatment of neurodegenerative diseases.

痴呆患病率的增加在我们的临床设置提出了核医学专家的诊断挑战。本研究的目的是回顾该程序的修改，并描述18F-FDG在不同临床适应症（包括经典和新出现的适应症）中使用脑PET的有用性。SEMNIM神经成像工作组认为有必要更新现有的西班牙语程序，以便为核医学专家和参与诊断和治疗神经退行性疾病的其他专业人员优化这项技术的质量和对其结果的解释。

引用次数: 0

Una comida sólida hipoalergénica para la gammagrafía de vaciado gástrico basada en la dieta mediterránea. «Una dieta para vaciarlos a todos» 一种基于地中海饮食的低致敏固体食物，用于胃排空伽玛图。《清空所有人的饮食》

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2024.500093

P. Zaragoza-Ballester , P. Sarandeses Fernández , I. González Martín , C. Martin-Arriscado Arroba , M.I. Cabanillas Pérez , X. Guarnizo Poma , I. Castel de Lucas , A. Galiana Morón , D. Vega Pérez , A.I. Romero Reina , M.J. Tabuenca Mateo , S. Ruiz Solís

Aim

We aim to establish normal values and standardize a hypoallergenic and Mediterranean diet for gastric emptying scintigraphy (GES).

Material and methods

In a prospective cohort of healthy volunteers, we performed GES of a [⁹⁹Tc]TcDTPA²⁻ labelled hypoallergenic meal (egg, potato, rice and olive oil). Anterior and posterior images were simultaneously acquired at 0, 30, 60, 110, 120, 130, 180, 230, 240 and 250 minutes. Cross-sectional analysis was performed between demographic data and gastric retention values. A score covariance analysis model was used to observer changes between measurements over time.

Results

50 participants (29 women) were included. Mean values and standard deviation (5-95th) for gastric retention percentages at 60, 120, 180, 240 minutes were 51.40 ± 8.63 (36.5-66.1), 21.66 ± 9.40 (6.5-38.2), 7.58 ± 5.77 (1.5-19.1) and 2.94 ± 2.08 (1-7.3), respectively. Male participants had a significative faster gastric emptying compared to women in practically all the acquisitions. Male participants and smoker participants generated a significative decrease of gastric retention values in generalized linear model (male coefficient −4.818, 95% CI: −7.24 to −2.39, P < .001; and smoker coefficient of −3.484, 95% CI: −6.29 to −0.67, P < .05).

Conclusion

This study standardizes and establishes normal values for GES with the first hypoallergenic solid meal based on consensus recommendations and a Mediterranean diet; suitable for most patients with allergic or sensitive-conditions to other meal components.

目的：建立低过敏性地中海饮食对胃排空造影（GES）的正常值和标准化。材料和方法在健康志愿者的前瞻性队列中，我们对[99Tc]TcDTPA2 -标记的低过敏性膳食（鸡蛋、土豆、大米和橄榄油）进行了GES。在0、30、60、110、120、130、180、230、240、250分钟同时获取前后位图像。在人口统计学数据和胃潴留值之间进行横断面分析。采用分数协方差分析模型观察各测量值随时间的变化。结果共纳入50例受试者，其中女性29例。60、120、180、240 min胃潴留率的平均值为51.40±8.63(36.5-66.1)，标准差为21.66±9.40(6.5-38.2),7.58±5.77(1.5-19.1),2.94±2.08(1-7.3)，标准差为5-95。在几乎所有的收购中，男性参与者的胃排空速度都明显快于女性。在广义线性模型中，男性参与者和吸烟者的胃潴留值显著降低(男性系数- 4.818,95% CI: - 7.24至- 2.39,P <；措施;吸烟者系数为- 3.484,95% CI: - 6.29 ~ - 0.67, P <；. 05)。结论：本研究基于共识建议和地中海饮食，以低过敏性固体餐为标准，建立了GES的正常值；适用于大多数对其他膳食成分过敏或敏感的患者。

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引用次数: 0

Justificación e impacto del uso de la SPECT 123I-FP-CIT en el diagnóstico diferencial y manejo de los trastornos del movimiento (TM) en un hospital de referencia nacional 在国家转诊医院使用SPECT 123I-FP-CIT进行运动障碍的鉴别诊断和管理的理由和影响

IF 1.6 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Revista Espanola De Medicina Nuclear E Imagen Molecular

Pub Date : 2025-07-01 DOI: 10.1016/j.remn.2024.500092

L. Canales Rodríguez , M. Mitjavila Casanovas , S. Ruiz Solís

Introduction

Cerebral single photon emission computed tomography (SPECT) using ¹²³I-FP-CIT is a key tool in the differential diagnosis of movement disorders (MD), but its appropriate indication is essential to optimize resources and avoid unnecessary tests.

Objective

To evaluate the adequacy and impact of SPECT ¹²³I-FP-CIT in the diagnosis and management of MD according to clinical guidelines.

Methodology

Retrospective study involving 249 patients with suspected parkinsonism (PK) of uncertain origin. All underwent SPECT ¹²³I-FP-CIT and had a clinical follow-up of exceeding 12 months. Requests were classified based on their adherence to clinical guidelines. Variables analyzed included sex, age, justification for the request, management after SPECT, and final diagnosis.

Results

91.57% of the requests were appropriate, while 8.43% did not adhere to the guidelines. Diagnosis changed in 48.6% of cases and management in 70.68% after the scan, especially in inconclusive cases and initiation of therapy. General neurologists evaluated more cases and made more appropriate requests (96,3% vs 76,67%;p < 0,001). However, MD specialists, despite less appropriate use of the text, achieved a higher number of conclusive diagnoses in complex cases.

Conclusion

SPECT ¹²³I-FP-CIT has significant clinical impact when used in accordance with clinical guidelines, improving the diagnosis and management of MD. Unjustified scans reduce its utility. Collaboration between general neurologists and MD specialists is fundamental; the latter, although showing less adherence to guidelines in requesting the test, achieve a higher number of conclusive diagnoses in complex cases.

使用123I-FP-CIT的大脑单光子发射计算机断层扫描（SPECT）是运动障碍（MD）鉴别诊断的关键工具，但其适当的适应症对于优化资源和避免不必要的检查至关重要。目的根据临床指南评价SPECT 123I-FP-CIT在MD诊断和治疗中的充分性和影响。方法回顾性研究249例来源不明的疑似帕金森病患者。所有患者均接受SPECT 123I-FP-CIT检查，临床随访超过12个月。根据对临床指南的遵守程度对请求进行分类。分析的变量包括性别、年龄、请求的理由、SPECT后的处理和最终诊断。结果91.57%的请求是合适的，8.43%的请求没有遵守指南。扫描后诊断改变48.6%，治疗改变70.68%，特别是在不确定病例和开始治疗时。普通神经科医生评估的病例更多，提出的要求也更恰当(96.3% vs 76.67%;p <；0001)。然而，医学专家，尽管不太适当地使用文本，在复杂病例中取得了更高数量的结论性诊断。结论按照临床指南使用spect 123I-FP-CIT具有显著的临床效果，提高了MD的诊断和管理，不合理的扫描降低了其应用价值。全科神经科医生和医学专家之间的合作至关重要；后者虽然在要求检测时较少遵守指南，但在复杂病例中获得更多的结论性诊断。

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