Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"Redefiniendo la localización preoperatoria basada en imágenes de los adenomas en pacientes con hiperparatiroidismo primario candidatos a cirugía mínimamente invasiva","authors":"S. Casanueva-Eliceiry ,&nbsp;M. Manyalich-Blasi ,&nbsp;A. Farré-Melero ,&nbsp;A. Niñerola-Baizán ,&nbsp;D. Saavedra ,&nbsp;M. Mora-Porta ,&nbsp;F.A. Hanzu ,&nbsp;A. Orois ,&nbsp;M. Squarcia ,&nbsp;M. Rodrigo-Calvo ,&nbsp;M. Tormo-Ratera ,&nbsp;K. Quintero-Martinez ,&nbsp;D. Fuster-Pelfort ,&nbsp;O. Vidal-Pérez ,&nbsp;S. Vidal-Sicart","doi":"10.1016/j.remn.2024.500091","DOIUrl":"10.1016/j.remn.2024.500091","url":null,"abstract":"<div><h3>Background and objectives</h3><div>To compare the diagnostic accuracy of [¹⁸F]-Fluorocholine (FCH) PET/CT with conventional [^99mTc]Tc-MIBI scintigraphy and cervical ultrasound (USG) for the preoperative localization of hyperfunctioning parathyroid tissue (HFPT) in patients with primary hyperparathyroidism (PHPT).</div></div><div><h3>Materials and methods</h3><div>This prospective study included 90 patients diagnosed with PHPT who underwent [¹⁸F]F-CH PET/CT, [^99mTc]Tc-MIBI SPECT/CT and Neck USG. The diagnostic accuracy of each imaging modality was assessed using intraoperative findings and histopathological confirmation as the gold standard. The localization accuracy was evaluated based on specific quadrant detection, laterality, and ectopic gland identification. The study also explored the correlation between imaging findings and biochemical parameters, including preoperative and postoperative PTH and calcium levels.</div></div><div><h3>Results</h3><div>[¹⁸F]F-CH PET/CT demonstrated superior accuracy in detecting pathological parathyroid glandscompared to [^99mTc]Tc-MIBI SPECT/CT and USG. [¹⁸F]F-CH PET/CT correctly identified 98.9% of patientswith pathological glands, with a specific location accuracy of 93.2%, 65.9% and 38.8% for [¹⁸F]F-CH PET/CT,[^99mTc]Tc-MIBI SPECT/CT and USG, respectively.</div><div>For ectopic adenomas, FCH PET/CT achieved an accuracy of 100% (4/4), while MIBI and neck ultrasound identified these in 50% (2/4) and 0% (0/4) of cases, respectively.</div><div>There were two cases of multiglandular disease, [¹⁸F]F-CH PET/CT and [99mTc]Tc-MIBI each detected one gland in one case (50%) while USG detected none; in the other case, [¹⁸F]F-CH PET/CT and USG identified both glands (100%), and [99mTc]Tc-MIBI detected none.</div><div>Significant correlations were observed between SUVmax values from [¹⁸F]F-CH PET/CT and gland size, weight, and preoperative PTH levels.</div></div><div><h3>Conclusions</h3><div>[¹⁸F]F-CH PET/CT outperformed conventional imaging modalities in the preoperative localization of HFPT, particularly in challenging cases such ectopic or multiglandular disease. These findings support its potential as an effective and reliable imaging tool for the management of primary hyperparathyroidism.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500091"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuevo método de heterogeneidad para predecir la supervivencia en el cáncer de mama triple negativo no metastásico","authors":"G.B. Babacan ,&nbsp;M.Ö. Tamam ,&nbsp;S. Saraçoğlu ,&nbsp;M.N. Acar Tayyar ,&nbsp;M.C. Şahin ,&nbsp;H. Özçevik ,&nbsp;G. Kulduk ,&nbsp;Ö.B. Ekinci ,&nbsp;E. Çelik","doi":"10.1016/j.remn.2025.500112","DOIUrl":"10.1016/j.remn.2025.500112","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the relationship between semiquantitative positron emission tomography (PET) parameters and intratumoral heterogeneity (ITH) on ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) imaging and survival data of non-metastatic triple-negative breast cancer (TNBC) patients.</div></div><div><h3>Methods</h3><div>Sixty-two consecutive female patients who underwent pretreatment ¹⁸F-FDG PET/CT with non-metastatic TNBC were enrolled. Heterogeneity index (HI) variables derived from the metabolic tumor volume (MTV) and standardized uptake value (SUV) parameters of primary lesions were evaluated. A novel modified method introducing a percentage-based (30-40-50%) MTV slope comparison was proposed. The association between conventional ¹⁸F-FDG PET/CT parameters, HI values, and survival results was analyzed retrospectively.</div></div><div><h3>Results</h3><div>Tumors with higher HI values were associated with shorter survival times. For overall survival (OS), HI2 and HI3 were statistically significant (<em>P</em>=.009, <em>P</em>=.016). Regarding radiological progression-free survival (rPFS), HI1 and HI3 were statistically significant (<em>P</em>=.01, <em>P</em>=.025). A significant weak correlation between HI1 (<em>P</em>=.005, rho=.34) and a strong correlation was found for HI2 (<em>P</em>&lt;.0001, rho=.89), HI3 and tumor size were not statistically significantly correlated (<em>P</em>=.063, rho=.23). T stage was statistically significantly associated with rPFS and OS (<em>P</em>=.038, <em>P</em>=.003). In contrast, no statistically significant difference was found for the N stage, anatomical, and clinical staging (<em>P</em>&gt;.05).</div></div><div><h3>Conclusion</h3><div>This study concluded that ITH predicts survival for non-metastatic TNBC patients. This conclusion was reached with the heterogeneity index variables obtained by different methods. However, our results revealed that HI2 depends on tumor size. Our modified method (HI3) predicts survival independently of tumor size.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500112"},"PeriodicalIF":1.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-FDG PET-TC en la hidatidosis multifocal","authors":"G. Molina-Mendoza,&nbsp;M.P. Talavera Rubio,&nbsp;F. López-Bermejo García,&nbsp;J. Gatón Ramírez,&nbsp;V.M. Poblete García","doi":"10.1016/j.remn.2025.500176","DOIUrl":"10.1016/j.remn.2025.500176","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500176"},"PeriodicalIF":1.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enfermedad de Erdheim Chester: diagnóstico y valoración de respuesta con PET/TC [18F]FDG","authors":"S. López Puche ,&nbsp;J.G. Villanueva Curto ,&nbsp;P. García-Talavera San Miguel ,&nbsp;J.A. Badell Martínez ,&nbsp;S. Rama Alonso ,&nbsp;M.P. Tamayo Alonso","doi":"10.1016/j.remn.2025.500179","DOIUrl":"10.1016/j.remn.2025.500179","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500179"},"PeriodicalIF":1.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicción de la respuesta completa a la quimiorradioterapia neoadyuvante en el cáncer de recto localmente avanzado: papel de los parámetros volumétricos basales de la PET/TC con [18F]FDG y los marcadores inflamatorios","authors":"G.U. Erdem ,&nbsp;O. Vural Topuz ,&nbsp;E. Acar ,&nbsp;T. Kapagan ,&nbsp;E. Yetim ,&nbsp;A. Ozmen ,&nbsp;S. Gurocak ,&nbsp;G. Usul ,&nbsp;S. Yuksel ,&nbsp;A.H. Yardimci ,&nbsp;N. Bulut","doi":"10.1016/j.remn.2025.500113","DOIUrl":"10.1016/j.remn.2025.500113","url":null,"abstract":"<div><h3>Objectives</h3><div>We evaluated the influence of baseline volumetric 18F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) parameters and inflammatory prognostic markers on complete response (CR) in patients with locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT).</div></div><div><h3>Materials and methods</h3><div>In total, 90 patients with LARC, including those with and without CR, were evaluated based on baseline volumetric PET/CT parameters, such as maximum standard uptake value, metabolic tumor volume (MTV), tumor lesion glycolysis, and inflammatory prognostic markers, including the lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio.</div></div><div><h3>Results</h3><div>Of the 90 patients, 62 (68.9%) were male and 28 (31.1%) were female. The median age was 61 (31-81) years. A complete response was observed in 20 (22%) patients following nCRT. Of these, 5 demonstrated a clinical complete response, whereas 15 exhibited a complete response after surgery. A low pretreatment PLR, low MTV levels, and stage 2 disease were identified as significant predictors of complete response. The optimal cutoff values were 16.5 for MTV (sensitivity 80%, specificity 62%) and 121 for PLR (sensitivity 73%, specificity 65%).</div></div><div><h3>Conclusion</h3><div>Our findings suggest that stage 2 disease, low pretreatment MTV, and low PLR levels may be predictive of a CR to nCRT in patients with LARC.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500113"},"PeriodicalIF":1.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMUNICACIONES ORALES (COMUNICACIONES ORALES)","authors":"","doi":"10.1016/S2253-654X(25)00136-2","DOIUrl":"10.1016/S2253-654X(25)00136-2","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 ","pages":"Pages S1-S137"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PÓSTERES (PÓSTERES)","authors":"","doi":"10.1016/S2253-654X(25)00137-4","DOIUrl":"10.1016/S2253-654X(25)00137-4","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 ","pages":"Pages S1-S179"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encuesta nacional sobre la imagen nuclear en patología ósea infecciosa: resultados y recomendaciones diagnósticas del Grupo de Trabajo de Patología Musculoesquelética (GT-PME)","authors":"E. Noriega-Álvarez ,&nbsp;A. Moreno-Ballesteros ,&nbsp;M. Velasco Nuño ,&nbsp;J.M. Cordero García ,&nbsp;J.J. Rosales Castillo ,&nbsp;U.V. Schmülling ,&nbsp;E. López Rodríguez ,&nbsp;A. Rigabert Sánchez-Junco ,&nbsp;B. Rodríguez Alfonso","doi":"10.1016/j.remn.2025.500165","DOIUrl":"10.1016/j.remn.2025.500165","url":null,"abstract":"<div><div>The continued increase in demand for diagnosis and monitoring of infectious bone diseases, along with the introduction of new equipment, radiopharmaceuticals, and techniques for this purpose, has made it necessary to dynamically update the existing protocols and recommendations. Therefore, the MSP-WG conducted a survey for spanish hospitals to complete and develop recommendations in the form of algorithms, in an attempt to combine existing scientific evidence with the reality of national clinical practice.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500165"},"PeriodicalIF":1.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencia de la fiebre en el 18F-FDG PET/TC in vivo utilizando un parámetro cuantitativo SUL","authors":"S. Huang ,&nbsp;M.S. Fang ,&nbsp;M. Zhao ,&nbsp;F. Li","doi":"10.1016/j.remn.2025.500127","DOIUrl":"10.1016/j.remn.2025.500127","url":null,"abstract":"<div><h3>Introduction</h3><div>Fever can affect the identification and efficacy evaluation of tumors on the ¹⁸F-FDG PET/CT, and this effect can be reduced by referring to normal tissue metabolism.The aim of the study was to analyze the influence of fever on glucose metabolism in the mediastinal blood pool, liver, spleen, and bone marrow utilizing PET/CT quantitative parameter SUV normalized by lean body mass(SUL).</div></div><div><h3>Materials and methods</h3><div>30 patients with fever of unknown origin and 24<!--> <!-->patients for tumor screening with normal body temperature within 3<!--> <!-->weeks, who underwent ¹⁸F-FDG PET/CT in our department, were analysed retrospectively. The SUL_max and SUL_mean of the mediastinal blood pool, liver, spleen, and bone marrow were respectively measured in the two groups, and the differences between the two groups were compared by independent sample t test or Wilcoxon-Mann-Whitney test.</div></div><div><h3>Results</h3><div>The SUL_max and SUL_mean of the liver in the fever group were lower than those in the control group (<em>P</em> <!-->=<!--> <!-->.001, .013). The SUL_max and SUL_mean of spleen and bone marrow in the fever group were higher than in the control group (all <em>P</em> <!-->&lt;<!--> <!-->.05). The SUL_max of the mediastinal blood pool in the fever group was lower than that in the control group (<em>P</em> <!-->=<!--> <!-->.007), but there was no significant difference in SUL_mean of the mediastinal between the fever group and the control group (T<!--> <!-->=<!--> <!-->1.181, <em>P</em> <!-->=<!--> <!-->.221).</div></div><div><h3>Conclusion</h3><div>The fever can affect the glucose metabolism in internal organs. But there was no significant difference in the SUL_mean of mediastinal blood pool. Perhaps the SUL_mean of the blood pool can be invoked as a calibration parameter in the evaluation of efficacy in tumor patients with fever.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500127"},"PeriodicalIF":1.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolucionando el tratamiento del cáncer de próstata: la terapia dirigida al antígeno prostático específico en el enfoque moderno terapéutico","authors":"A. Ricaurte Fajardo ,&nbsp;V. Marulanda Corzo ,&nbsp;S. Ruder ,&nbsp;D.R. Cardoza-Ochoa ,&nbsp;C.E. Granados ,&nbsp;D. Yadav ,&nbsp;D. Lopez ,&nbsp;M. Fatima ,&nbsp;S. Dutruel ,&nbsp;E. O’Dwyer ,&nbsp;J.R. Osborne ,&nbsp;S.T. Tagawa ,&nbsp;S. Huicochea Castellanos","doi":"10.1016/j.remn.2025.500162","DOIUrl":"10.1016/j.remn.2025.500162","url":null,"abstract":"<div><div>Prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy has reshaped the treatment landscape for metastatic castration-resistant prostate cancer (mCRPC), offering new therapeutic possibilities beyond conventional approaches. Among the most promising strategies is lutetium-177 PSMA-617, which has shown significant benefits in overall survival and durable PSA responses, as demonstrated in several clinical trials.</div><div>At the same time, the development of novel radionuclides such as actinium-225 has opened the door to more potent treatments capable of overcoming prior resistance, particularly in patients previously exposed to beta emitters. The use of PSMA PET imaging and the identification of predictive biomarkers have helped refine patient selection, contributing to a more personalized approach. Comparative studies with agents like cabazitaxel have further supported the safety and effectiveness of this strategy.</div><div>This article provides a critical overview of clinical advances in PSMA-targeted radionuclide therapy, examines emerging combination treatments, reviews the development of alpha-emitting agents, and highlights the role of personalized dosimetry in clinical practice, underlining the growing importance of this therapeutic modality across different stages of prostate cancer.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500162"},"PeriodicalIF":1.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}