Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"Estadificación en el cáncer de nasofaringe: valor pronóstico de los parámetros volumétricos de la PET/TC con [18F]FDG","authors":"Ç. Erol ,&nbsp;Ö. Şahin ,&nbsp;G. Kanyılmaz ,&nbsp;S. Erol","doi":"10.1016/j.remn.2025.500160","DOIUrl":"10.1016/j.remn.2025.500160","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of our study was to determine whether volumetric parameters measured from the primary lesion and metastatic lymph node (LN) using [¹⁸F]FDG PET/CT imaging affect prognosis and survival in nasopharyngeal cancer (NPC) patients.</div></div><div><h3>Material and methods</h3><div>Our study included 62 patients diagnosed with NPC who underwent [¹⁸F]FDG PET/CT imaging for pre-treatment staging. SUVmax, SUVmean, MTV and TLG values were measured from the primary tumor and LN. Lymph node/primary tumor SUV ratio (NTR) was calculated. The relationships between volumetric parameters and overall survival (OS), locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS) and progression-free survival (PFS) were evaluated.</div></div><div><h3>Results</h3><div>LN SUVmax and LN SUVmean values were significantly higher in patients with distant metastases (<em>P</em> =.002 and <em>P</em> =.016, respectively). NTR values were significantly higher in patients with distant metastases (<em>P</em>=.047). The ideal LN SUVmax and SUVmean cut-off values for predicting distant metastasis in patients with LN metastasis were 16.45 and 6.5, respectively. There was a statistically significant difference between the DMFSs of the two groups when the NTR cut-off value was 0.8 (<em>P</em>=.047). Multivariate analysis showed that LN SUVmax, LN SUVmean and NTR were associated with DMFS (<em>P</em>=.003, 0.05 and 0.014, respectively), while primary tumor TLG and MTV values were associated with LRRFS (<em>P</em>=.035 and 0.03, respectively).</div></div><div><h3>Conclusion</h3><div>In conclusion, we believe that LN SUVmax, SUVmean and NTR may be prognostic indicators for distant metastasis, and MTV and TLG for locoregional recurrence.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500160"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reacciones adversas mediadas por [99mTc]Tc-tetrofosmina: revisión de la literatura y análisis de informes poscomercialización","authors":"S. Martins ,&nbsp;S. Costa ,&nbsp;M. Sousa ,&nbsp;F. Moreira ,&nbsp;A. Martín-Suaréz ,&nbsp;Â. Jesus","doi":"10.1016/j.remn.2025.500166","DOIUrl":"10.1016/j.remn.2025.500166","url":null,"abstract":"<div><h3>Introduction</h3><div>^99mTc-tetrofosmin is a diagnostic radiopharmaceutical used to evaluate cardiac pathologies. Despite the lower incidence of reactions compared to other drugs, radiopharmaceuticals can still cause adverse reactions. For this reason, pharmacovigilance plays a crucial role in detecting, understanding, evaluating and preventing them.</div></div><div><h3>Objective</h3><div>This study aims to review the available literature, on the safety of ^99mTc-tetrofosmin, and to analyze spontaneous adverse drug reaction reports from the European EudraVigilance database.</div></div><div><h3>Methods</h3><div>A literature review was conducted according to PRISMA methodology. An analysis of spontaneous notifications was carried out in EudraVigilance, until 2022.</div></div><div><h3>Results</h3><div>The review identified a selection of 7 articles. The most reported adverse reactions were skin irritation, strange taste in the mouth and nausea. Regarding the EudraVigilance analysis, 220 notifications were identified, accounting for 477 adverse reactions. The majority belong to males (51%), between 18-64 years (45%). Health professionals were the main reporters (84%). The most prevalent System Organ Class was “general disorders and administration site conditions” (21%) and the most reported adverse reaction was pruritus (10%). Approximately 67% of reactions were considered serious, with 6 fatal cases recorded.</div></div><div><h3>Conclusion</h3><div>The results demonstrated that adverse reactions associated with ^99mTc-tetrofosmin do occur and should not be minimized. Over a period of 17 years, only 220 notifications were recorded, which may highlight potential challenges in pharmacovigilance for radiopharmaceuticals. Therefore, raising awareness about the importance of reporting adverse reactions is crucial.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500166"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/TC en cáncer de mama","authors":"J.F. Bastidas ,&nbsp;M. Martínez de Bourio-Allona ,&nbsp;A. Roteta Unceta Barrenechea ,&nbsp;M. Rodríguez-Fraile ,&nbsp;L. Sancho","doi":"10.1016/j.remn.2025.500139","DOIUrl":"10.1016/j.remn.2025.500139","url":null,"abstract":"<div><div>Breast cancer is one of the most prevalent neoplasms worldwide, with molecular subtypes that influence prognosis and therapeutic strategies. PET/CT with different radiopharmaceuticals has revolutionized diagnosis, staging, and treatment monitoring. [¹⁸F]-Fluorodeoxyglucose remains the most widely used radiotracer, but it has limitations in certain subtypes, such as invasive lobular carcinoma, where 16α-[¹⁸F] fluoro-17β-estradiol and [⁶⁸Ga]-FAPI (fibroblast activation protein inhibitors) have demonstrated greater utility. Today, HER2-targeted radiopharmaceuticals, such as [⁸⁹Zr]-trastuzumab, allow for a precise assessment of tumor heterogeneity. PET/CT also plays a key role in detecting bone metastases using [¹⁸F]-NaF and in identifying new therapeutic targets, such as PSMA (prostate-specific membrane antigen) and GRPR (gastrin-releasing peptide receptor). These advancements establish molecular imaging as an essential tool for personalizing breast cancer treatment, optimizing clinical decision-making, and improving diagnostic accuracy.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500139"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145469026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPECT/TC con 99mTc-sestamibi en el diagnóstico de masas renales","authors":"L. Pinilla,&nbsp;E. Riera,&nbsp;J.R. García,&nbsp;L. Mont-Castro,&nbsp;M. Soria,&nbsp;E. Valls","doi":"10.1016/j.remn.2025.500197","DOIUrl":"10.1016/j.remn.2025.500197","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500197"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aportación del 123I en la estrumosis peritoneal","authors":"L. Delgado Niño ,&nbsp;J. Romero Martínez ,&nbsp;F. Martín Ordoñez","doi":"10.1016/j.remn.2025.500200","DOIUrl":"10.1016/j.remn.2025.500200","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500200"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68Ga-FAPI y 18F-FDG PET/TC: modalidades de imagen complementarias para detectar metástasis inusuales en un paciente con osteosarcoma","authors":"G.A. Divband ,&nbsp;E. Askari ,&nbsp;H. Amini ,&nbsp;A. Noferesti ,&nbsp;P. Sahafi","doi":"10.1016/j.remn.2025.500137","DOIUrl":"10.1016/j.remn.2025.500137","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500137"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145469027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Un año de contribuciones clave del Grupo de Trabajo de Oncología de la SEMNim","authors":"M. Rodríguez-Fraile","doi":"10.1016/j.remn.2025.500211","DOIUrl":"10.1016/j.remn.2025.500211","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500211"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linfoma B difuso de célula grande que simula enfermedad de Erdheim-Chester en la PET/TC con 18F-FDG","authors":"L. Yang ,&nbsp;P. Dong ,&nbsp;L. Li,&nbsp;M. Su","doi":"10.1016/j.remn.2025.500156","DOIUrl":"10.1016/j.remn.2025.500156","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500156"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal bone tuberculosis with adrenal involvement mimicking malignant tumors with multiple metastases on PET/CT","authors":"W. Zhang,&nbsp;Y. Xing,&nbsp;A. Kuang,&nbsp;Y. Li","doi":"10.1016/j.remn.2025.500141","DOIUrl":"10.1016/j.remn.2025.500141","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500141"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curso clínico y características del cáncer oncocítico de tiroides (células de Hürthle): comparación con el carcinoma folicular de tiroides","authors":"K. Okuyucu ,&nbsp;U.M. Turan ,&nbsp;P. Akkus Gunduz ,&nbsp;M. Ozkara ,&nbsp;N. Aydinbelge Dizdar ,&nbsp;A. Cinar ,&nbsp;M. Samsum ,&nbsp;P. Sahin Oguz ,&nbsp;R.D. Zeyrek ,&nbsp;N. Ersoz Gulcelik ,&nbsp;S. Ince","doi":"10.1016/j.remn.2025.500158","DOIUrl":"10.1016/j.remn.2025.500158","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Although oncocytic (Hurthle cell) carcinoma (OTC) resembles to follicular thyroid carcinoma (FTC), they are different tumours derived from thyroid follicular cells. OTC comprises 3-5% of all differentiated thyroid carcinomas and has more aggressive behaviour than FTC. Clinicians discuss about the treatment and prognosis of OTC. We evaluated its clinicopathological features and clinical course.</div></div><div><h3>Material and methods</h3><div>We examined and followed up 169 patients with OTC (126 minimally invasive, 43 widely invasive) and 837 patients with FTC (640 minimally invasive, 197 widely invasive). OTC and FTC were compared according to prognostic variables, recurrence rate (Rec) and outcome. The predictor factors impacting on recurrence in OTC were also determined.</div></div><div><h3>Results</h3><div>There were statistically significant differences between OTC and FTC in age, sex, capsule invasion (CI), tumor size (TS), total administered [¹³¹I]NaI dose (TID), stimulated thyroglobulin (sTg), Rec and stage (<em>P</em> <!-->&lt;<!--> <!-->.001, <em>P</em> <!-->=<!--> <!-->.032, <em>P</em> <!-->&lt;<!--> <!-->.001, <em>P</em> <!-->&lt;<!--> <!-->.001, <em>P</em> <!-->=<!--> <!-->.004, <em>P</em> <!-->=<!--> <!-->.026, <em>P</em> <!-->=<!--> <!-->.017, <em>P</em> <!-->=<!--> <!-->.044, respectively). Age, CI, extrathyroidal extension (ETE), TS, initial lymph node metastasis (ILNM), sTg and stage (<em>P</em> <!-->=<!--> <!-->.01, <em>P</em> <!-->=<!--> <!-->.016, <em>P</em> <!-->&lt;<!--> <!-->.001, <em>P</em> <!-->&lt;<!--> <!-->.001, <em>P</em> <!-->&lt;<!--> <!-->.001, <em>P</em> <!-->&lt;<!--> <!-->.001, <em>P</em> <!-->&lt;<!--> <!-->.001, respectively) were the predictors for recurrence in OTC. Metastasis incidence was 19.5% for OTC and 12% for FTC. The cause of death was cancer in 25 patients with FTC (2.8%) and 11 patients with OTC (6.5%).</div></div><div><h3>Conclusion</h3><div>The prognosis of minimally invasive OTC is quite favorable. However the prognosis of widely invasive OTC is unfavorable. RAI may be administered to these tumors, but it is in vain to insist on RAI after the first adjuvant therapy if it does not respond.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500158"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}