Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"Modelo para predecir riesgo de fallecimiento de causa cardíaca según características clínicas y parámetros del gated-SPECT de perfusión miocárdica","authors":"G. Rodríguez Cabalé ,&nbsp;E. Rodríguez Cabalé ,&nbsp;V. Pubul Núñez ,&nbsp;Á. Ruibal Morell","doi":"10.1016/j.remn.2025.500132","DOIUrl":"10.1016/j.remn.2025.500132","url":null,"abstract":"<div><h3>Background</h3><div>Coronary artery disease is a complex, multifactorial process with high prevalence and morbidity-mortality. Single photon emission computed tomography (SPECT) myocardial perfusion imaging synchronized with the electrocardiogram (gated-SPECT) is a non-invasive imaging technique that has demonstrated high sensitivity and specificity for diagnosis and staging. To better predict the risk of adverse events, it is necessary to analyze the simultaneous behavior of clinical elements and diagnostic tests, a type of study that is scarce in the current literature. This research evaluated the relationship between clinical characteristics and gated-SPECT myocardial perfusion parameters with progression to cardiac death; subsequently, a model was built to predict the risk of such an outcome.</div></div><div><h3>Methods</h3><div>An observational, longitudinal, and retrospective study was conducted with 2 230 patients who underwent this test due to suspected coronary artery disease. Clinical characteristics, test parameters, and progression to cardiac death were collected and the relationships between them were studied. A logistic regression model was built to study the relationships between the variables and their influence on the probability of progression to cardiac death.</div></div><div><h3>Results</h3><div>Clinical characteristics associated with a higher probability of cardiac death were male sex (OR<!--> <!-->=<!--> <!-->5.104, <em>P</em> <!-->=<!--> <!-->0.004), peripheral arterial disease (OR<!--> <!-->=<!--> <!-->7.175, <em>P</em> <!-->&lt;<!--> <!-->0.001), and diabetes mellitus (OR<!--> <!-->=<!--> <!-->3.159, <em>P</em> <!-->=<!--> <!-->0.013). The gated-SPECT parameters associated with a higher risk of this outcome were VTS ≥70<!--> <!-->ml (OR<!--> <!-->=<!--> <!-->12.257, <em>P</em> <!-->&lt;<!--> <!-->0.001), EF &lt;<!--> <!-->50% (OR<!--> <!-->=<!--> <!-->10.757, <em>P</em> <!-->&lt;<!--> <!-->0.001), VTD ≥140<!--> <!-->ml (OR<!--> <!-->=<!--> <!-->8.884, <em>P</em> <!-->&lt;<!--> <!-->0.001), ventricular dilation (OR<!--> <!-->=<!--> <!-->8.959, <em>P</em> <!-->&lt;<!--> <!-->0.001), and reversible defects (OR<!--> <!-->=<!--> <!-->7.454, <em>P</em> <!-->=<!--> <!-->0.001). Fixed defects, parietal motility abnormalities, the presence of both reversible and fixed defects, and the hyperdynamic gated state were also associated with a higher risk of cardiac death but with lower ORs.</div><div>The logistic regression model showed good overall performance and high ability to determine progression to cardiac death, close to perfect predictive capacity (AUC<!--> <!-->=<!--> <!-->0.9656).</div></div><div><h3>Conclusions</h3><div>It is necessary to employ total cardiovascular risk models that include results from diagnostic tests such as gated-SPECT. The constructed model demonstrated good overall performance and is a valid proposal for predicting the risk of death due to cardiac causes.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500132"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicción de la respuesta completa a la quimiorradioterapia neoadyuvante en el cáncer de recto localmente avanzado: papel de los parámetros volumétricos basales de la PET/TC con [18F]FDG y los marcadores inflamatorios","authors":"G.U. Erdem ,&nbsp;O. Vural Topuz ,&nbsp;E. Acar ,&nbsp;T. Kapagan ,&nbsp;E. Yetim ,&nbsp;A. Ozmen ,&nbsp;S. Gurocak ,&nbsp;G. Usul ,&nbsp;S. Yuksel ,&nbsp;A.H. Yardimci ,&nbsp;N. Bulut","doi":"10.1016/j.remn.2025.500113","DOIUrl":"10.1016/j.remn.2025.500113","url":null,"abstract":"<div><h3>Objectives</h3><div>We evaluated the influence of baseline volumetric 18F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) parameters and inflammatory prognostic markers on complete response (CR) in patients with locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT).</div></div><div><h3>Materials and methods</h3><div>In total, 90 patients with LARC, including those with and without CR, were evaluated based on baseline volumetric PET/CT parameters, such as maximum standard uptake value, metabolic tumor volume (MTV), tumor lesion glycolysis, and inflammatory prognostic markers, including the lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio.</div></div><div><h3>Results</h3><div>Of the 90 patients, 62 (68.9%) were male and 28 (31.1%) were female. The median age was 61 (31-81) years. A complete response was observed in 20 (22%) patients following nCRT. Of these, 5 demonstrated a clinical complete response, whereas 15 exhibited a complete response after surgery. A low pretreatment PLR, low MTV levels, and stage 2 disease were identified as significant predictors of complete response. The optimal cutoff values were 16.5 for MTV (sensitivity 80%, specificity 62%) and 121 for PLR (sensitivity 73%, specificity 65%).</div></div><div><h3>Conclusion</h3><div>Our findings suggest that stage 2 disease, low pretreatment MTV, and low PLR levels may be predictive of a CR to nCRT in patients with LARC.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500113"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuevo método de heterogeneidad para predecir la supervivencia en el cáncer de mama triple negativo no metastásico","authors":"G.B. Babacan ,&nbsp;M.Ö. Tamam ,&nbsp;S. Saraçoğlu ,&nbsp;M.N. Acar Tayyar ,&nbsp;M.C. Şahin ,&nbsp;H. Özçevik ,&nbsp;G. Kulduk ,&nbsp;Ö.B. Ekinci ,&nbsp;E. Çelik","doi":"10.1016/j.remn.2025.500112","DOIUrl":"10.1016/j.remn.2025.500112","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the relationship between semiquantitative positron emission tomography (PET) parameters and intratumoral heterogeneity (ITH) on ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) imaging and survival data of non-metastatic triple-negative breast cancer (TNBC) patients.</div></div><div><h3>Methods</h3><div>Sixty-two consecutive female patients who underwent pretreatment ¹⁸F-FDG PET/CT with non-metastatic TNBC were enrolled. Heterogeneity index (HI) variables derived from the metabolic tumor volume (MTV) and standardized uptake value (SUV) parameters of primary lesions were evaluated. A novel modified method introducing a percentage-based (30-40-50%) MTV slope comparison was proposed. The association between conventional ¹⁸F-FDG PET/CT parameters, HI values, and survival results was analyzed retrospectively.</div></div><div><h3>Results</h3><div>Tumors with higher HI values were associated with shorter survival times. For overall survival (OS), HI2 and HI3 were statistically significant (<em>P</em>=.009, <em>P</em>=.016). Regarding radiological progression-free survival (rPFS), HI1 and HI3 were statistically significant (<em>P</em>=.01, <em>P</em>=.025). A significant weak correlation between HI1 (<em>P</em>=.005, rho=.34) and a strong correlation was found for HI2 (<em>P</em>&lt;.0001, rho=.89), HI3 and tumor size were not statistically significantly correlated (<em>P</em>=.063, rho=.23). T stage was statistically significantly associated with rPFS and OS (<em>P</em>=.038, <em>P</em>=.003). In contrast, no statistically significant difference was found for the N stage, anatomical, and clinical staging (<em>P</em>&gt;.05).</div></div><div><h3>Conclusion</h3><div>This study concluded that ITH predicts survival for non-metastatic TNBC patients. This conclusion was reached with the heterogeneity index variables obtained by different methods. However, our results revealed that HI2 depends on tumor size. Our modified method (HI3) predicts survival independently of tumor size.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500112"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencia de la fiebre en el 18F-FDG PET/TC in vivo utilizando un parámetro cuantitativo SUL","authors":"S. Huang ,&nbsp;M.S. Fang ,&nbsp;M. Zhao ,&nbsp;F. Li","doi":"10.1016/j.remn.2025.500127","DOIUrl":"10.1016/j.remn.2025.500127","url":null,"abstract":"<div><h3>Introduction</h3><div>Fever can affect the identification and efficacy evaluation of tumors on the ¹⁸F-FDG PET/CT, and this effect can be reduced by referring to normal tissue metabolism.The aim of the study was to analyze the influence of fever on glucose metabolism in the mediastinal blood pool, liver, spleen, and bone marrow utilizing PET/CT quantitative parameter SUV normalized by lean body mass(SUL).</div></div><div><h3>Materials and methods</h3><div>30 patients with fever of unknown origin and 24<!--> <!-->patients for tumor screening with normal body temperature within 3<!--> <!-->weeks, who underwent ¹⁸F-FDG PET/CT in our department, were analysed retrospectively. The SUL_max and SUL_mean of the mediastinal blood pool, liver, spleen, and bone marrow were respectively measured in the two groups, and the differences between the two groups were compared by independent sample t test or Wilcoxon-Mann-Whitney test.</div></div><div><h3>Results</h3><div>The SUL_max and SUL_mean of the liver in the fever group were lower than those in the control group (<em>P</em> <!-->=<!--> <!-->.001, .013). The SUL_max and SUL_mean of spleen and bone marrow in the fever group were higher than in the control group (all <em>P</em> <!-->&lt;<!--> <!-->.05). The SUL_max of the mediastinal blood pool in the fever group was lower than that in the control group (<em>P</em> <!-->=<!--> <!-->.007), but there was no significant difference in SUL_mean of the mediastinal between the fever group and the control group (T<!--> <!-->=<!--> <!-->1.181, <em>P</em> <!-->=<!--> <!-->.221).</div></div><div><h3>Conclusion</h3><div>The fever can affect the glucose metabolism in internal organs. But there was no significant difference in the SUL_mean of mediastinal blood pool. Perhaps the SUL_mean of the blood pool can be invoked as a calibration parameter in the evaluation of efficacy in tumor patients with fever.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500127"},"PeriodicalIF":1.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importancia pronóstica de las distancias normalizadas entre el punto de captación máxima estandarizado del radiotrazador y el centro tumoral en la PET/TC con 18F-FDG en el carcinoma de células escamosas de cabeza y cuello","authors":"S.-P. Hong ,&nbsp;S.M. Lee ,&nbsp;I.D. Yoo ,&nbsp;I.Y. Jo ,&nbsp;Y.K. Won ,&nbsp;M.-S. Kim ,&nbsp;H.J. Choi ,&nbsp;J. Won Lee ,&nbsp;S.J. Jang","doi":"10.1016/j.remn.2025.500103","DOIUrl":"10.1016/j.remn.2025.500103","url":null,"abstract":"<div><h3>Objective</h3><div>The maximum ¹⁸F-FDG uptake of a cancer lesion has been found to relocate from the center to the periphery during progression. This behavior proposes that the normalized distances from the hotspot of radiotracer uptake to the tumor centroid (NHOC) and to the tumor perimeter (NHOP) could serve as novel geometric PET parameters indicative of tumor aggressiveness. This study aimed to explore the prognostic relevance of NHOC and NHOP in ¹⁸F-FDG PET/CT for predicting the response to concurrent chemoradiotherapy (CCRT) and progression-free survival (PFS) in patients with head and neck squamous cell carcinoma.</div></div><div><h3>Materials and methods</h3><div>We retrospectively reviewed 116 head and neck squamous cell carcinoma patients who received CCRT and were assessed with pre-treatment (PET1) and 3 months post-treatment PET/CT (PET2). Along with conventional PET parameters, NHOC and NHOP for primary tumors on PET1 and the percent changes in NHOC and NHOP between PET1 and PET2 were measured.</div></div><div><h3>Results</h3><div>Of all the PET1 parameters assessed, NHOC was the most effective in predicting the CCRT response, achieving an area under the receiver operating characteristic curve of 0.645. In multivariate logistic regression and survival analysis, NHOC identified as an independent predictor for both complete metabolic response (p<!--> <!-->=<!--> <!-->0.028) and PFS (p<!--> <!-->=<!--> <!-->0.006). In a subgroup of 46 patients exhibiting residual primary tumors on PET2, both the percent changes in NHOC (p<!--> <!-->=<!--> <!-->0.048) and NHOP (p<!--> <!-->=<!--> <!-->0.041) were significantly associated with PFS.</div></div><div><h3>Conclusions</h3><div>NHOC and the percent changes in NHOC and NHOP following CCRT may serve as effective ¹⁸F-FDG PET/CT parameters for predicting clinical outcomes in head and neck squamous cell carcinoma patients.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500103"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome de activación macrofágica en un paciente pediátrico: hallazgos en PET/TC con 18F-FDG","authors":"J.P. Suárez Fernández,&nbsp;M.L. Domínguez Grande,&nbsp;C. Vigil Díaz,&nbsp;B. Fernández Llana,&nbsp;N. Martín Fernández,&nbsp;F.M. González García","doi":"10.1016/j.remn.2025.500183","DOIUrl":"10.1016/j.remn.2025.500183","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500183"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilidad de la PET/TC con [18F]FDG más allá de la estadificación: importancia pronóstica de la sarcopenia y del metabolismo del tejido adiposo en el carcinoma esofágico","authors":"M.N. Acar Tayyar ,&nbsp;M. Öner Tamam ,&nbsp;G. Buğrahan Babacan ,&nbsp;M. Can Şahin ,&nbsp;H. Özçevik ,&nbsp;N. Gürdal ,&nbsp;K. Atakır","doi":"10.1016/j.remn.2024.500090","DOIUrl":"10.1016/j.remn.2024.500090","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to investigate the relationship between PET and CT parameters and sarcopenia, adipose tissue, and tumor metabolism in esophageal carcinoma (EC) and its impact on survival in EC.</div></div><div><h3>Method</h3><div>Our study included 122 EC patients who underwent PET/CT for staging. Muscle and adipose tissue characteristics were evaluated, including lumbar (L3) and cervical (C3) muscle areas, psoas major (PM) and sternocleidomastoid muscle (SCM) parameters, and PET parameters for visceral and subcutaneous adipose tissue (SAT). Sarcopenia was determined using CT images, with a threshold for muscle tissue at the L3 vertebral level, and its impact on overall survival (OS) was investigated.</div></div><div><h3>Results</h3><div>Sarcopenia was detected in 48 patients. SULmax in the primary tumor (PT) was significantly higher in sarcopenic patients (SP). The frequency of distant metastasis was higher in SP and OS was significantly lower. In the locally advanced stage, sarcopenia status decreased survival. L3, PM, C3, and SCM muscle areas were highly correlated. Subcutaneous adipose tissue SUVmax was significantly increased in SP and those with distant metastasis. Univariate analysis identified PT SULmax, PT SUVmean, PT TLG, lymph node and distant metastasis, SAT SUVmax, and sarcopenia as poor prognostic factors, while multivariate analysis confirmed BMI, distant metastasis, PT SUVmean, PT TLG as independent predictors of OS.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that sarcopenia, linked to reduced survival, correlates with primary tumor SULmax, distant metastasis, and subcutaneous tissue PET parameters, exerting a notable impact on survival, particularly in locally advanced stages. Attenuation-corrected CT can be used instead of diagnostic CT, and sarcopenia can be diagnosed using not only L3 but also C3 slices.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500090"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/TC con 18F-FDG de doble tiempo en un caso de linfoma extranodal primario hepático de zona marginal del tejido linfoide asociado a mucosa","authors":"R. Yang,&nbsp;Z. Zheng,&nbsp;Y. Lin,&nbsp;H. Shi","doi":"10.1016/j.remn.2025.500105","DOIUrl":"10.1016/j.remn.2025.500105","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500105"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación del angiosarcoma cardíaco mediante [18F]FDG PET/TC","authors":"B. Hervás-Sanz ,&nbsp;N. Ruiz-Roig ,&nbsp;L. Rodríguez-Bel ,&nbsp;L.M. Gràcia-Sánchez ,&nbsp;M. Cortés-Romera ,&nbsp;P.C. Notta","doi":"10.1016/j.remn.2025.500131","DOIUrl":"10.1016/j.remn.2025.500131","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500131"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/TC con [18F]FDG en el diagnóstico y evaluación de respuesta al tratamiento en un paciente con sarcoidosis sistémica","authors":"J.P. Suárez Fernández,&nbsp;S. Naranjo Sancho,&nbsp;M.L. Domínguez Grande,&nbsp;C. Vigil Díaz,&nbsp;N. Martín Fernández,&nbsp;F.M. González García","doi":"10.1016/j.remn.2025.500135","DOIUrl":"10.1016/j.remn.2025.500135","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500135"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}