Pub Date : 2025-05-01Epub Date: 2025-02-12DOI: 10.1016/j.remn.2024.500085
G. Kara Gedik , A. Volkan Çelik , M.U. Yalçın , M. Koplay , F. Yılmaz , H. Önner
<div><h3>Introduction and objectives</h3><div>Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).</div></div><div><h3>Materials and methods</h3><div>Eighty six patients in whom NAC, AC and prone images were obtained with SPECT, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied. Myocardial perfusion scintigraphy was performed using SPECT/CT dual-headed gamma camera. Images were evaluated qualitatively and semi-quantitatively using 20-segment model. Analyzes of global myocardium and LAD, RCA, Cx vascular areas as regional analysis were performed. In qualitative evaluation, if SPECT study was abnormal, relevant coronary artery area was recorded. Quantitative Perfusion SPECT (QPS) program was used in semi-quantitative analysis; Summed Stress Score (SSS)<!--> <!-->≥<!--> <!-->4 was accepted for presence of CAD in per-patient analysis. In regional analysis SSS<!--> <!-->≥<!--> <!-->2 was taken into account. Coronary angiography/CT coronary angiography was used as gold standard. Threshold value was determined as ≥<!--> <!-->50% and above luminal diameter narrowing. While AC and NAC methods were compared for per-patient analysis and each vascular area; 3<!--> <!-->imaging methods including prone acquisition, were compared for the RCA area. Diagnostic performances of the methods were evaluated by comparing the areas under the curve with ROC analysis.</div></div><div><h3>Results</h3><div>In visual evaluation, sensitivity of AC was significantly lower than NAC in analyzes of per-patient, RCA and Cx areas (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%, respectively; <em>P</em> <!--><<!--> <!-->.05). Sensitivity of prone imaging was significantly higher than AC in analysis of the RCA area (76.09% vs 60.87%, respectively; <em>P</em> <!--><<!--> <!-->.05) Specificity values were higher in analyzes of global, RCA and Cx areas in AC than in NAC method; this difference was significant in RCA and Cx areas (RCA 70% vs 42.50%, Cx 85.11% vs 70.21%, respectively; <em>P</em> <!--><<!--> <!-->.05). In semi-quantitative evaluation, AC and NAC had similar sensitivity and specificity in global and regional analyzes; in RCA area, no significant difference was detected between the 3<!--> <!-->methods. In ROC analysis, no significant difference was detected between methods in per-patient and regional analyzes both in visual and semi-quantitative evaluation.</div></div><div><h3>Conclusions</h3><div>CT-based attenuation correction increases specificity, but reduces sensitivity in the diagnosis of CAD in
问题衰减降低了心肌灌注成像单光子发射断层扫描（SPECT）的特异性，导致诊断准确性降低。本研究的目的是比较非衰减校正（NAC）、基于计算机断层扫描的衰减校正（AC）和倾向图像在定性和半定量分析心肌灌注SPECT诊断冠状动脉疾病（CAD）中的表现。材料与方法回顾性分析66例在3个月内完成冠状动脉造影/CT冠状动脉造影并经SPECT获得NAC、AC及俯卧位图像的患者。采用SPECT/CT双头伽马照相机进行心肌灌注显像。采用20段模型对图像进行定性和半定量评价。局部分析整体心肌及LAD、RCA、Cx血管区。定性评价时，如SPECT显像异常，记录相关冠状动脉面积。半定量分析采用定量灌注SPECT （QPS）程序；在每例患者分析中，接受压力总分(SSS)≥4作为存在CAD的标准。在区域分析中，考虑SSS≥2。冠状动脉造影/CT冠状动脉造影为金标准。阈值确定为≥50%及以上的管腔直径变窄。而AC和NAC方法在每个患者和每个血管区域的分析比较；比较了包括俯卧采集在内的3种成像方法对RCA区域的成像效果。通过曲线下面积与ROC分析的比较，评价各方法的诊断效果。结果在目视评价中，AC对单个患者、RCA和Cx区域的敏感性显著低于NAC (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%)；P & lt;. 05)。俯卧位成像对RCA区域的敏感度显著高于AC（分别为76.09%和60.87%）；P & lt;0.05) AC法的全局、RCA和Cx区特异性值高于NAC法；RCA和Cx区差异显著(RCA分别为70% vs 42.50%， Cx为85.11% vs 70.21%；P & lt;. 05)。在半定量评价中，AC和NAC在全局和区域分析中具有相似的敏感性和特异性；在RCA区，3种方法间差异无统计学意义。在ROC分析中，在目测和半定量评估中，个体分析和区域分析的方法没有发现显著差异。结论基于ct的衰减校正增加了特异性，但降低了RCA和Cx局部区域诊断CAD的敏感性。俯卧位成像仍然是评估RCA区域的重要手段。
{"title":"Comparación de los rendimientos diagnósticos de la gammagrafía de perfusión miocárdica SPECT corregida por atenuación por TC y corregida sin atenuación en la enfermedad de las arterias coronarias","authors":"G. Kara Gedik , A. Volkan Çelik , M.U. Yalçın , M. Koplay , F. Yılmaz , H. Önner","doi":"10.1016/j.remn.2024.500085","DOIUrl":"10.1016/j.remn.2024.500085","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).</div></div><div><h3>Materials and methods</h3><div>Eighty six patients in whom NAC, AC and prone images were obtained with SPECT, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied. Myocardial perfusion scintigraphy was performed using SPECT/CT dual-headed gamma camera. Images were evaluated qualitatively and semi-quantitatively using 20-segment model. Analyzes of global myocardium and LAD, RCA, Cx vascular areas as regional analysis were performed. In qualitative evaluation, if SPECT study was abnormal, relevant coronary artery area was recorded. Quantitative Perfusion SPECT (QPS) program was used in semi-quantitative analysis; Summed Stress Score (SSS)<!--> <!-->≥<!--> <!-->4 was accepted for presence of CAD in per-patient analysis. In regional analysis SSS<!--> <!-->≥<!--> <!-->2 was taken into account. Coronary angiography/CT coronary angiography was used as gold standard. Threshold value was determined as ≥<!--> <!-->50% and above luminal diameter narrowing. While AC and NAC methods were compared for per-patient analysis and each vascular area; 3<!--> <!-->imaging methods including prone acquisition, were compared for the RCA area. Diagnostic performances of the methods were evaluated by comparing the areas under the curve with ROC analysis.</div></div><div><h3>Results</h3><div>In visual evaluation, sensitivity of AC was significantly lower than NAC in analyzes of per-patient, RCA and Cx areas (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%, respectively; <em>P</em> <!--><<!--> <!-->.05). Sensitivity of prone imaging was significantly higher than AC in analysis of the RCA area (76.09% vs 60.87%, respectively; <em>P</em> <!--><<!--> <!-->.05) Specificity values were higher in analyzes of global, RCA and Cx areas in AC than in NAC method; this difference was significant in RCA and Cx areas (RCA 70% vs 42.50%, Cx 85.11% vs 70.21%, respectively; <em>P</em> <!--><<!--> <!-->.05). In semi-quantitative evaluation, AC and NAC had similar sensitivity and specificity in global and regional analyzes; in RCA area, no significant difference was detected between the 3<!--> <!-->methods. In ROC analysis, no significant difference was detected between methods in per-patient and regional analyzes both in visual and semi-quantitative evaluation.</div></div><div><h3>Conclusions</h3><div>CT-based attenuation correction increases specificity, but reduces sensitivity in the diagnosis of CAD in","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500085"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-04-11DOI: 10.1016/j.remn.2025.500125
D. Mut Surmeli
{"title":"Re: «Evaluación del papel de la sarcopenia y los parámetros [18F]FDG PET/TC en el pronóstico del adenocarcinoma ductal pancreático»","authors":"D. Mut Surmeli","doi":"10.1016/j.remn.2025.500125","DOIUrl":"10.1016/j.remn.2025.500125","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500125"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-03-08DOI: 10.1016/j.remn.2024.500087
H. Ji , S. Jiang , C. Sun , T. Liu , G. Yang , L. Zhang , J. Sun , J. Wu
Objective
The aim of this study is to analyze the correlation between [18F]-FDG PET/CT (positron emission tomography/computed tomography) findings and pathological subtypes of lung adenocarcinoma with ground-glass opacity (GGO).
Materials and methods
88 patients were included in this study, which underwent [18F]-FDG PET/CT and were finally diagnosed with lung adenocarcinoma. A total of 90 GGO lesions were analyzed. The size and SUVmax of all lesions were measured, the proportion of solid components of GGO in lesions was calculated, and quantitative classification was performed. The above GGO lesions were divided into three groups based on the 2011 IASLC/ATS/ERS lung adenocarcinoma pathological classification, namely good prognosis group, relatively good prognosis group and poor prognosis group. Chi-square test, independent sample t test, and analysis of variance were used for statistical analysis.
Results
There was a negative correlation between the SUVmax and quantitative classification value (r =−0.638, P < 0.001). Atypical adenomatous hyperplasia (AAH), acinar predominant adenocarcinoma (APA), lepidic predominant adenocarcinoma (LPA), papillary predominant adenocarcinoma (PPA), and solid pre-dominant adenocarcinoma (SPA) had significant differences in GGO lesion size, SUVmax, and quantitative classification value (F = 3.849, P = 0.019; F = 27.420, P < 0.001; F = 4.353, P = 0.002). There were significant differences in GGO lesion size, SUVmax, and quantitative classification value among the good prognosis group, relatively good prognosis group, and poor prognosis group (F = 5.626, P = 0.011; F = 37.587, P < 0.001; F = 5.119, P = 0.008).
Conclusion
GGO lesion size, SUVmax, and quantitative classification value are correlated with different pathological subtypes and can be used to evaluate the prognosis of lung adenocarcinoma with GGO.
目的分析[18F]-FDG PET/CT（正电子发射断层扫描/计算机断层扫描）表现与肺腺癌磨玻璃样混浊（GGO）病理亚型的相关性。材料与方法本研究纳入88例患者，经[18F]-FDG PET/CT检查，最终诊断为肺腺癌。共分析90例GGO病变。测量所有病变的大小和SUVmax，计算病变中GGO固体成分的比例，并进行定量分类。根据2011 IASLC/ATS/ERS肺腺癌病理分类将上述GGO病变分为预后良好组、预后较好组和预后较差组。统计学分析采用卡方检验、独立样本t检验和方差分析。结果SUVmax与定量分类值呈负相关(r = - 0.638, P <；0.001)。非典型腺瘤性增生（AAH）、腺泡显性腺癌（APA）、鳞状显性腺癌（LPA）、乳头状显性腺癌（PPA）和实体性显性腺癌（SPA）在GGO病变大小、SUVmax和定量分类值上存在显著差异(F = 3.849, P = 0.019；F = 27.420, P <；0.001;F = 4.353, p = 0.002)。预后良好组、预后较好组、预后较差组间GGO病变大小、SUVmax及定量分类值差异均有统计学意义(F = 5.626, P = 0.011；F = 37.587, P <；0.001;F = 5.119, p = 0.008)。结论go病变大小、SUVmax及定量分级值与不同病理亚型相关，可用于评价肺腺癌伴GGO的预后。
{"title":"Correlación entre los hallazgos de la PET/TC con [18F]FDG y los subtipos histológicos de adenocarcinoma de pulmón que se presentan como opacidad en vidrio deslustrado","authors":"H. Ji , S. Jiang , C. Sun , T. Liu , G. Yang , L. Zhang , J. Sun , J. Wu","doi":"10.1016/j.remn.2024.500087","DOIUrl":"10.1016/j.remn.2024.500087","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to analyze the correlation between [18F]-FDG PET/CT (positron emission tomography/computed tomography) findings and pathological subtypes of lung adenocarcinoma with ground-glass opacity (GGO).</div></div><div><h3>Materials and methods</h3><div>88 patients were included in this study, which underwent [18F]-FDG PET/CT and were finally diagnosed with lung adenocarcinoma. A total of 90 GGO lesions were analyzed. The size and SUV<sub>max</sub> of all lesions were measured, the proportion of solid components of GGO in lesions was calculated, and quantitative classification was performed. The above GGO lesions were divided into three groups based on the 2011 IASLC/ATS/ERS lung adenocarcinoma pathological classification, namely good prognosis group, relatively good prognosis group and poor prognosis group. Chi-square test, independent sample t test, and analysis of variance were used for statistical analysis.</div></div><div><h3>Results</h3><div>There was a negative correlation between the SUV<sub>max</sub> and quantitative classification value (<em>r</em> =−0.638, <em>P</em> < 0.001). Atypical adenomatous hyperplasia (AAH), acinar predominant adenocarcinoma (APA), lepidic predominant adenocarcinoma (LPA), papillary predominant adenocarcinoma (PPA), and solid pre-dominant adenocarcinoma (SPA) had significant differences in GGO lesion size, SUV<sub>max</sub>, and quantitative classification value (<em>F</em> = 3.849, <em>P</em> = 0.019; <em>F</em> = 27.420, <em>P</em> < 0.001; <em>F</em> = 4.353, <em>P</em> = 0.002). There were significant differences in GGO lesion size, SUV<sub>max</sub>, and quantitative classification value among the good prognosis group, relatively good prognosis group, and poor prognosis group (<em>F</em> = 5.626, <em>P</em> = 0.011; <em>F</em> = 37.587, <em>P</em> < 0.001; <em>F</em> = 5.119, <em>P</em> = 0.008).</div></div><div><h3>Conclusion</h3><div>GGO lesion size, SUV<sub>max</sub>, and quantitative classification value are correlated with different pathological subtypes and can be used to evaluate the prognosis of lung adenocarcinoma with GGO.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500087"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-02-05DOI: 10.1016/j.remn.2025.500120
A. Bota-Bota, M. Pombo-López, I. Martínez-Rodríguez, F. Gómez-de la Fuente, J. Jiménez-Bonilla, R. Quirce
{"title":"Metástasis única de melanoma maligno cutáneo en la vesícula biliar detectada con 18F-FDG PET/TC","authors":"A. Bota-Bota, M. Pombo-López, I. Martínez-Rodríguez, F. Gómez-de la Fuente, J. Jiménez-Bonilla, R. Quirce","doi":"10.1016/j.remn.2025.500120","DOIUrl":"10.1016/j.remn.2025.500120","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500120"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2024-12-03DOI: 10.1016/j.remn.2024.500081
F. Sebastián Palacid , N. Álvarez Mena , M. García Aragón , R.d.C. Zambrano Infantino , B.M. Jaramillo López , J. Gómez Hidalgo , B. Pérez López , M.P. Redondo del Río , R. Ruano Pérez
Purpose
To evaluate the feasibility of identifying various distribution patterns of [99mTc]Tc-DPD in patients with cardiac transthyretin amyloidosis using gated SPECT-CT.
Materials and methods
Gated SPECT-CT was performed in patients with a positive scintigraphy result for cardiac amyloidosis due to transthyretin (TTR-CA). Patients were categorized into several groups based on sex, degree of radiopharmaceutical uptake according to the Perugini's visual scale and ventricular ejection fraction (LVEF). Cardiac polar maps were obtained using Emory Cardiac Toolbox™ software and scored by segments according to radiopharmaceutical uptake on a scale from 0 (no uptake) to 4 (very high uptake intensity). The Mann-Whitney U and Pearson's Chi-square statistical tests were employed to identify significant differences in distribution patterns according to the different variables under study.
Results
A total of 65 patients were evaluated. The gender variable determined the main statistically significant differences, highlighting distinct distribution patterns of the radiopharmaceutical at the cardiac level: while women showed lower accumulation of [99mTc]Tc-DPD in the middle anterior (P = 0.035) and basal anterior (P = 0.001) segments, whereas men demonstrated higher accumulation in the basal anteroseptal (P = 0.009) and basal inferoseptal (P = 0.009) segments, and lower scores in the lateroapical segment (P = 0.039).
Conclusions
Gated SPECT-CT is an essential tool for assessing the distribution pattern of [99mTc]Tc-DPD of patients with TTR-CA, offering valuable insights into the pathophysiology of the disease.
{"title":"Papel del [99mTc]Tc-DPD gated-SPECT-TC en la evaluación de los patrones de captación miocárdica de la amiloidosis por transtiretina (AC-TTR)","authors":"F. Sebastián Palacid , N. Álvarez Mena , M. García Aragón , R.d.C. Zambrano Infantino , B.M. Jaramillo López , J. Gómez Hidalgo , B. Pérez López , M.P. Redondo del Río , R. Ruano Pérez","doi":"10.1016/j.remn.2024.500081","DOIUrl":"10.1016/j.remn.2024.500081","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the feasibility of identifying various distribution patterns of [<sup>99m</sup>Tc]Tc-DPD in patients with cardiac transthyretin amyloidosis using gated SPECT-CT.</div></div><div><h3>Materials and methods</h3><div>Gated SPECT-CT was performed in patients with a positive scintigraphy result for cardiac amyloidosis due to transthyretin (TTR-CA). Patients were categorized into several groups based on sex, degree of radiopharmaceutical uptake according to the Perugini's visual scale and ventricular ejection fraction (LVEF). Cardiac polar maps were obtained using Emory Cardiac Toolbox™ software and scored by segments according to radiopharmaceutical uptake on a scale from 0 (no uptake) to 4 (very high uptake intensity). The Mann-Whitney U and Pearson's Chi-square statistical tests were employed to identify significant differences in distribution patterns according to the different variables under study.</div></div><div><h3>Results</h3><div>A total of 65 patients were evaluated. The gender variable determined the main statistically significant differences, highlighting distinct distribution patterns of the radiopharmaceutical at the cardiac level: while women showed lower accumulation of [<sup>99m</sup>Tc]Tc-DPD in the middle anterior (<em>P</em> <!-->=<!--> <!-->0.035) and basal anterior (<em>P</em> <!-->=<!--> <!-->0.001) segments, whereas men demonstrated higher accumulation in the basal anteroseptal (<em>P</em> <!-->=<!--> <!-->0.009) and basal inferoseptal (<em>P</em> <!-->=<!--> <!-->0.009) segments, and lower scores in the lateroapical segment (<em>P</em> <!-->=<!--> <!-->0.039).</div></div><div><h3>Conclusions</h3><div>Gated SPECT-CT is an essential tool for assessing the distribution pattern of [<sup>99m</sup>Tc]Tc-DPD of patients with TTR-CA, offering valuable insights into the pathophysiology of the disease.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500081"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-03-10DOI: 10.1016/j.remn.2024.500089
P. Mínguez Gabiña , T. Monserrat Fuertes , B. Santos Zorrozua , A. Esteban Figueruelo , M.A. Astudillo Sarmiento , A. Peña Fuentes , I. Vinagre Pérez , E. Rodeño Ortiz de Zarate , I.L. Fernández Tercero
Purpose
The main objectives were to study differences between the first and the fourth cycle in dosimetry variables in patients treated for neuroendocrine tumours with four cycles of [177Lu]Lu-DOTA-TATE, as well as to look for absorbed dose–effect correlations aiming to help individualise and optimise this therapy for future patients.
Material and methods
SPECT based dosimetry of tumour lesions and kidneys was performed in the first and the fourth cycles of the [177Lu]Lu-DOTA-TATE treatments for 17 patients from 2020 to 2023. Clinical variables of interest were collected in order to look for correlations with some dosimetry variables. Statistical analysis was performed using the R software.
Results
Regarding dosimetry variables, for lesions a significant decrease in absorbed dose, mass and initial activity between the first and fourth cycles was observed. For kidneys, a significant increase in absorbed dose was observed. Effective decay constants did not significantly change neither for lesions nor for kidneys. The relative decrease in lesion masses correlated with their total absorbed dose. Total absorbed doses to kidneys were well below the toxicity limits mostly used in this therapy. Relative decr
ease in lesion absorbed doses was significantly lower for tumour primary sites in ileum and jejunum compared to those in pancreas. Moreover, radiological response correlated with clinical response.
Conclusions
The results seem to indicate that the current treatment scheme could be optimised in order to obtain better treatment outcomes.
{"title":"Análisis de variables dosimétricas y clínicas en el tratamiento de los tumores neuroendocrinos con [177Lu]Lu-DOTA-TATE","authors":"P. Mínguez Gabiña , T. Monserrat Fuertes , B. Santos Zorrozua , A. Esteban Figueruelo , M.A. Astudillo Sarmiento , A. Peña Fuentes , I. Vinagre Pérez , E. Rodeño Ortiz de Zarate , I.L. Fernández Tercero","doi":"10.1016/j.remn.2024.500089","DOIUrl":"10.1016/j.remn.2024.500089","url":null,"abstract":"<div><h3>Purpose</h3><div>The main objectives were to study differences between the first and the fourth cycle in dosimetry variables in patients treated for neuroendocrine tumours with four cycles of [<sup>177</sup>Lu]Lu-DOTA-TATE, as well as to look for absorbed dose–effect correlations aiming to help individualise and optimise this therapy for future patients.</div></div><div><h3>Material and methods</h3><div>SPECT based dosimetry of tumour lesions and kidneys was performed in the first and the fourth cycles of the [<sup>177</sup>Lu]Lu-DOTA-TATE treatments for 17 patients from 2020 to 2023. Clinical variables of interest were collected in order to look for correlations with some dosimetry variables. Statistical analysis was performed using the R software.</div></div><div><h3>Results</h3><div>Regarding dosimetry variables, for lesions a significant decrease in absorbed dose, mass and initial activity between the first and fourth cycles was observed. For kidneys, a significant increase in absorbed dose was observed. Effective decay constants did not significantly change neither for lesions nor for kidneys. The relative decrease in lesion masses correlated with their total absorbed dose. Total absorbed doses to kidneys were well below the toxicity limits mostly used in this therapy. Relative decr</div><div>ease in lesion absorbed doses was significantly lower for tumour primary sites in ileum and jejunum compared to those in pancreas. Moreover, radiological response correlated with clinical response.</div></div><div><h3>Conclusions</h3><div>The results seem to indicate that the current treatment scheme could be optimised in order to obtain better treatment outcomes.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500089"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-02-15DOI: 10.1016/j.remn.2025.500121
R. Luo, W. Zhang, A. Kuang, Y. Li
{"title":"Características de imagen poco comunes de la osteomielitis multifocal recurrente crónica en adultos en PET/CT","authors":"R. Luo, W. Zhang, A. Kuang, Y. Li","doi":"10.1016/j.remn.2025.500121","DOIUrl":"10.1016/j.remn.2025.500121","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500121"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-02-12DOI: 10.1016/j.remn.2024.500086
S. Malhotra , A. Peix , C. Gutierrez-Villamil , M. Bazan , R. Giubbini , C. Cueva , E. Estrada , D. Paez
Latin America is one of the regions in the world with the highest levels of overweight, dyslipidemia, and diabetes mellitus, which, together with smoking and high blood pressure, are common risk factors for cardiovascular and oncological diseases. Chemotherapy (CT) and radiotherapy (RT) have become two of the mainstays of treatment for several types of cancer. One of the most worrisome side effects generated by CT and RT is cardiotoxicity. There are several imaging techniques in cardiology that can inform the presence of underlying disease, but they differ in their availability and access to the masses, their accuracy and repeatability, all of which are important determinants of the applicability of these techniques in routine clinical practice. Thus, it is mandatory to promote a clinically effective and a cost-effective multimodality approach for risk stratification, diagnosis and management of cardiovascular diseases in oncologic patients. The purpose of this review is to inform cardiologists, oncologists, cardio-oncologists and imaging cardiologists on the cardiac imaging modalities that can be applied in patients with cancer, the differences among imaging techniques and recommendations on how to apply them in Latin America.
{"title":"Aplicación práctica de la imagen multimodal en la cardio-oncología en América Latina","authors":"S. Malhotra , A. Peix , C. Gutierrez-Villamil , M. Bazan , R. Giubbini , C. Cueva , E. Estrada , D. Paez","doi":"10.1016/j.remn.2024.500086","DOIUrl":"10.1016/j.remn.2024.500086","url":null,"abstract":"<div><div>Latin America is one of the regions in the world with the highest levels of overweight, dyslipidemia, and diabetes mellitus, which, together with smoking and high blood pressure, are common risk factors for cardiovascular and oncological diseases. Chemotherapy (CT) and radiotherapy (RT) have become two of the mainstays of treatment for several types of cancer. One of the most worrisome side effects generated by CT and RT is cardiotoxicity. There are several imaging techniques in cardiology that can inform the presence of underlying disease, but they differ in their availability and access to the masses, their accuracy and repeatability, all of which are important determinants of the applicability of these techniques in routine clinical practice. Thus, it is mandatory to promote a clinically effective and a cost-effective multimodality approach for risk stratification, diagnosis and management of cardiovascular diseases in oncologic patients. The purpose of this review is to inform cardiologists, oncologists, cardio-oncologists and imaging cardiologists on the cardiac imaging modalities that can be applied in patients with cancer, the differences among imaging techniques and recommendations on how to apply them in Latin America.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500086"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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