首页 > 最新文献

Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

英文 中文
Utilidad de la PET/TC con [18F]F-fluorocolina en la valoración de respuesta a la terapia antiandrogénica en pacientes con cáncer de próstata 含[18F]氟胆碱的PET/TC在评估前列腺癌患者抗雄激素治疗反应中的作用
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.remn.2024.500083
K. Quintero , E. Vila , L. Ferrer-Mileo , D. Vas , Maria J. Ribal , M. Garcia-Herreros , N. Navarro , M. Tormo-Ratera , C. Aversa , A. Vilaseca , A. Farré-Melero , D. Fuster , P. Paredes , grupo de Medicina Nuclear Clínic Barcelona (MNCB)

Objective

To evaluate the correlation between response assessment measured by PET/CT with [18F] F-fluorocholine (Choline PET/CT) and serum levels of PSA in patients with prostate cancer under antiandrogenic treatment.

Methodology

A retrospective study included patients with CRPC and CSPC treated with enzalutamide, abiraterone, or apalutamide between June 2018 and July 2021, who underwent baseline and a follow-up Choline PET/CT. The difference in maximum SUVmax (ΔSUV) between both studies and the PSA value before and at follow-up were recorded. The response to treatment was compared by PSA vs. PET, assessing their association, agreement, and correlation.

Results

Thirty patients were included (median age 74 years, range 68-78), 12 with CSPC and 18 with CRPC; 22 had nodal disease, and 15 had active bone disease. The average time between pre-treatment and follow-up PET/CT was 11 months (range 3.5-23).
Patients with extra-nodal metastatic disease at the beginning of treatment showed a higher correlation between PSA and ΔSUV (OR 4.375). In patients with bone disease at the start of treatment, 80% were classified as non-responders on PET response assessment, while only 40% were non-responders by PSA.
The correlation between PET and PSA was mild (Kendall's tau_b 0.26), and the classification into Responders/Non-responders had only slight agreement (Cohen's kappa 0.30).

Conclusion

Choline PET/CT shows low concordance with the PSA values obtained during the follow-up of response to anti-androgen therapy, especially in patients with bone involvement.
目的探讨抗雄激素治疗前列腺癌患者用[18F] f -氟胆碱PET/CT (Choline PET/CT)测定的疗效评价与血清PSA水平的相关性。回顾性研究纳入了2018年6月至2021年7月期间接受恩杂鲁胺、阿比特龙或阿帕鲁胺治疗的CRPC和CSPC患者,这些患者接受了基线和随访的胆碱PET/CT检查。记录两项研究的最大SUVmax (ΔSUV)与随访前和随访时PSA值的差异。通过PSA和PET比较对治疗的反应,评估它们的相关性、一致性和相关性。结果30例患者(中位年龄74岁,68 ~ 78岁),其中CSPC 12例,CRPC 18例;22例为结节性疾病,15例为活动性骨病。从治疗前到随访PET/CT平均时间为11个月(范围3.5-23)。治疗开始时淋巴结外转移性疾病患者的PSA与ΔSUV的相关性更高(OR 4.375)。在治疗开始时患有骨病的患者中,80%的人在PET反应评估中被归类为无反应,而只有40%的人在PSA中被归类为无反应。PET与PSA之间的相关性较弱(Kendall的tau_b为0.26),而应答者/无应答者的分类只有轻微的一致性(Cohen的kappa为0.30)。结论胆碱PET/CT与抗雄激素治疗应答随访时PSA值一致性较低,尤其是累及骨的患者。
{"title":"Utilidad de la PET/TC con [18F]F-fluorocolina en la valoración de respuesta a la terapia antiandrogénica en pacientes con cáncer de próstata","authors":"K. Quintero ,&nbsp;E. Vila ,&nbsp;L. Ferrer-Mileo ,&nbsp;D. Vas ,&nbsp;Maria J. Ribal ,&nbsp;M. Garcia-Herreros ,&nbsp;N. Navarro ,&nbsp;M. Tormo-Ratera ,&nbsp;C. Aversa ,&nbsp;A. Vilaseca ,&nbsp;A. Farré-Melero ,&nbsp;D. Fuster ,&nbsp;P. Paredes ,&nbsp;grupo de Medicina Nuclear Clínic Barcelona (MNCB)","doi":"10.1016/j.remn.2024.500083","DOIUrl":"10.1016/j.remn.2024.500083","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the correlation between response assessment measured by PET/CT with [<sup>18</sup>F] F-fluorocholine (Choline PET/CT) and serum levels of PSA in patients with prostate cancer under antiandrogenic treatment.</div></div><div><h3>Methodology</h3><div>A retrospective study included patients with CRPC and CSPC treated with enzalutamide, abiraterone, or apalutamide between June 2018 and July 2021, who underwent baseline and a follow-up Choline PET/CT. The difference in maximum SUVmax (ΔSUV) between both studies and the PSA value before and at follow-up were recorded. The response to treatment was compared by PSA vs. PET, assessing their association, agreement, and correlation.</div></div><div><h3>Results</h3><div>Thirty patients were included (median age 74 years, range 68-78), 12 with CSPC and 18 with CRPC; 22 had nodal disease, and 15 had active bone disease. The average time between pre-treatment and follow-up PET/CT was 11 months (range 3.5-23).</div><div>Patients with extra-nodal metastatic disease at the beginning of treatment showed a higher correlation between PSA and ΔSUV (OR 4.375). In patients with bone disease at the start of treatment, 80% were classified as non-responders on PET response assessment, while only 40% were non-responders by PSA.</div><div>The correlation between PET and PSA was mild <em>(Kendall's tau_b</em> 0.26), and the classification into Responders/Non-responders had only slight agreement (<em>Cohen's kappa</em> 0.30).</div></div><div><h3>Conclusion</h3><div>Choline PET/CT shows low concordance with the PSA values obtained during the follow-up of response to anti-androgen therapy, especially in patients with bone involvement.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 2","pages":"Article 500083"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valor clínico de un PET/TC con [18F]F-PSMA negativo en pacientes diagnosticados de cáncer de próstata tratados con prostatectomía con elevación del PSA, inferior a 1 ng/ml, en los resultados de la radioterapia de rescate 在接受前列腺切除术治疗、PSA升高小于1纳克/毫升的前列腺癌患者中,具有[18F]F-PSMA阴性的PET/ CT临床值
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.remn.2024.500071
M. Cózar Santiago , J. García Garzón , A. Esteban Hurtado , J. Pastor Peiro , J. Ferrer Rebolleda

Objective

To assess the clinical value of [18F]F-PSMA negative PET/CT, in patients diagnosed with prostate cancer treated with prostatectomy with elevated PSA less than 1 ng/mL, on the outcome of salvage radiotherapy.

Method

We prospectively included 98 patients diagnosed with prostate cancer treated with prostatectomy with biochemical recurrence [mean PSA 0.51 ng/mL (range 0.17-1,0 ng/mL)] who were referred for an [18F]F-PSMA-PET/CT study.
The [18F]F-PSMA-PET/CT scan was negative in 53/98 patients (54.09%). Differences were analysed between those patients who were or were not candidates for pelvic salvage radiotherapy (PSRT) decided upon multidisciplinary committee and patient consent, with a minimum follow-up time for 1 year. Response to treatment was defined as a 50% reduction in PSA levels. Recurrence was ascertained upon clinical, analytical and imaging follow-up outcomes.

Results

54.7% (29/53) of the patients with a negative [18F]F-PSMA-PET/CT underwent PSRT. Of these, 93.1% (27/29) patients demonstrated response to treatment (PSMA false negatives). The remaining two patients showed fluctuating PSA levels without detecting disease on the [18F]F-PSMA-PET/CT follow-up study.
45.3% (24/53) of patients with negative [18F]F-PSMA-PET/CT did not undergo PSRT. Of these, progressive PSA elevation was observed in 62.5% (15/24) (PSMA false negatives), localising recurrence on the [18F]F-PSMA-PET/CT follow-up study in 4 patients. The remaining 9 patients (37.5%) showed fluctuating PSA levels without detecting disease on the [18F]F-PSMA-PET/CT follow-up study.
Our series confirmed 42 (42.85%) [18F]F-PSMA-PET/CT false negatives cases.

Conclusion

Patients diagnosed with prostate cancer with post-prostatectomy biochemical recurrence and a negative [18F]F-PSMA-PET/CT study are likely to benefit from pelvic salvage radiotherapy, with response seen in 93.1% of our cases.
目的探讨[18F]F-PSMA阴性PET/CT对前列腺癌行前列腺切除术且PSA升高小于1 ng/mL患者补救性放疗预后的临床价值。方法前瞻性纳入98例经前列腺切除术诊断为前列腺癌并生化复发的患者[平均PSA 0.51 ng/mL(范围0.17-1,0 ng/mL)],转介进行[18F]F-PSMA-PET/CT研究。[18F]F-PSMA-PET/CT扫描阴性53/98例(54.09%)。经多学科委员会和患者同意决定是否接受盆腔保留放疗(PSRT)的患者之间进行差异分析,随访时间至少为1年。对治疗的反应被定义为PSA水平降低50%。结果54.7%(29/53)的F-PSMA-PET/CT阴性患者接受了PSRT治疗。其中,93.1%(27/29)患者表现出对治疗的反应(PSMA假阴性)。其余2例患者在[18F]F-PSMA-PET/CT随访研究中显示PSA水平波动,但未发现疾病,45.3%(24/53)的[18F]F-PSMA-PET/CT阴性患者未进行PSRT。其中,62.5%(15/24)的患者出现进行性PSA升高(PSMA假阴性),在[18F]F-PSMA-PET/CT随访研究中,4例患者出现局部复发。其余9例(37.5%)患者在[18F]F-PSMA-PET/CT随访研究中显示PSA水平波动,但未发现疾病。本组共确诊42例(42.85%)[18F]F-PSMA-PET/CT假阴性。结论诊断为前列腺癌的前列腺切除术后生化复发且F-PSMA-PET/CT阴性的患者可能受益于盆腔补救性放疗,93.1%的病例有反应。
{"title":"Valor clínico de un PET/TC con [18F]F-PSMA negativo en pacientes diagnosticados de cáncer de próstata tratados con prostatectomía con elevación del PSA, inferior a 1 ng/ml, en los resultados de la radioterapia de rescate","authors":"M. Cózar Santiago ,&nbsp;J. García Garzón ,&nbsp;A. Esteban Hurtado ,&nbsp;J. Pastor Peiro ,&nbsp;J. Ferrer Rebolleda","doi":"10.1016/j.remn.2024.500071","DOIUrl":"10.1016/j.remn.2024.500071","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the clinical value of [<sup>18</sup>F]F-PSMA negative PET/CT, in patients diagnosed with prostate cancer treated with prostatectomy with elevated PSA less than 1<!--> <!-->ng/mL, on the outcome of salvage radiotherapy.</div></div><div><h3>Method</h3><div>We prospectively included 98 patients diagnosed with prostate cancer treated with prostatectomy with biochemical recurrence [mean PSA 0.51<!--> <!-->ng/mL (range 0.17-1,0<!--> <!-->ng/mL)] who were referred for an [<sup>18</sup>F]F-PSMA-PET/CT study.</div><div>The [<sup>18</sup>F]F-PSMA-PET/CT scan was negative in 53/98 patients (54.09%). Differences were analysed between those patients who were or were not candidates for pelvic salvage radiotherapy (PSRT) decided upon multidisciplinary committee and patient consent, with a minimum follow-up time for 1<!--> <!-->year. Response to treatment was defined as a 50% reduction in PSA levels. Recurrence was ascertained upon clinical, analytical and imaging follow-up outcomes.</div></div><div><h3>Results</h3><div>54.7% (29/53) of the patients with a negative [<sup>18</sup>F]F-PSMA-PET/CT underwent PSRT. Of these, 93.1% (27/29) patients demonstrated response to treatment (PSMA false negatives). The remaining two patients showed fluctuating PSA levels without detecting disease on the [<sup>18</sup>F]F-PSMA-PET/CT follow-up study.</div><div>45.3% (24/53) of patients with negative [<sup>18</sup>F]F-PSMA-PET/CT did not undergo PSRT. Of these, progressive PSA elevation was observed in 62.5% (15/24) (PSMA false negatives), localising recurrence on the [<sup>18</sup>F]F-PSMA-PET/CT follow-up study in 4 patients. The remaining 9 patients (37.5%) showed fluctuating PSA levels without detecting disease on the [<sup>18</sup>F]F-PSMA-PET/CT follow-up study.</div><div>Our series confirmed 42 (42.85%) [<sup>18</sup>F]F-PSMA-PET/CT false negatives cases.</div></div><div><h3>Conclusion</h3><div>Patients diagnosed with prostate cancer with post-prostatectomy biochemical recurrence and a negative [<sup>18</sup>F]F-PSMA-PET/CT study are likely to benefit from pelvic salvage radiotherapy, with response seen in 93.1% of our cases.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 2","pages":"Article 500071"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Técnica de marcaje con semilla radiactiva de 125-I en endometriosis inguinal 用125-I放射性种子进行腹腔镜子宫内膜异位症标记的技术
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.remn.2024.500069
L. Rodríguez-Díaz , E. García , C. de Guirior , R. Salvador , J. Ribera-Perianes , S. Vidal-Sicart
{"title":"Técnica de marcaje con semilla radiactiva de 125-I en endometriosis inguinal","authors":"L. Rodríguez-Díaz ,&nbsp;E. García ,&nbsp;C. de Guirior ,&nbsp;R. Salvador ,&nbsp;J. Ribera-Perianes ,&nbsp;S. Vidal-Sicart","doi":"10.1016/j.remn.2024.500069","DOIUrl":"10.1016/j.remn.2024.500069","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 2","pages":"Article 500069"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amiloidosis intestinal secundaria visualizada en una gammagrafía con [99mTc]Tc-HMDP 用[99mTc]Tc-HMDP进行的放射照相显示继发性肠淀粉样变
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-03-01 DOI: 10.1016/j.remn.2024.500070
S. Bondia-Bescós , I.E. Sánchez-Rodríguez , A. Palomar-Muñoz , P. Notta , M. Cortés-Romera , L.M. Gràcia-Sánchez
{"title":"Amiloidosis intestinal secundaria visualizada en una gammagrafía con [99mTc]Tc-HMDP","authors":"S. Bondia-Bescós ,&nbsp;I.E. Sánchez-Rodríguez ,&nbsp;A. Palomar-Muñoz ,&nbsp;P. Notta ,&nbsp;M. Cortés-Romera ,&nbsp;L.M. Gràcia-Sánchez","doi":"10.1016/j.remn.2024.500070","DOIUrl":"10.1016/j.remn.2024.500070","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 2","pages":"Article 500070"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diseminación metastásica muscular atípica detectada por PET/TC con 18F-FDG en leiomiosarcoma retroperitoneal de alto grado PET/TC在严重腹膜后肌肉瘤中发现18F-FDG的非典型转移性肌肉扩散
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-17 DOI: 10.1016/j.remn.2024.500094
R. Valverde-Jorge , M. Díez-García , I. Vinagre-Pérez , L. Mosteiro-González , I. Ratón Zulueta , I. Fernández-Tercero
{"title":"Diseminación metastásica muscular atípica detectada por PET/TC con 18F-FDG en leiomiosarcoma retroperitoneal de alto grado","authors":"R. Valverde-Jorge ,&nbsp;M. Díez-García ,&nbsp;I. Vinagre-Pérez ,&nbsp;L. Mosteiro-González ,&nbsp;I. Ratón Zulueta ,&nbsp;I. Fernández-Tercero","doi":"10.1016/j.remn.2024.500094","DOIUrl":"10.1016/j.remn.2024.500094","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500094"},"PeriodicalIF":1.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Características de imagen poco comunes de la osteomielitis multifocal recurrente crónica en adultos en PET/CT PET/CT组成人慢性复发多灶骨髓炎的罕见成像特征
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-15 DOI: 10.1016/j.remn.2025.500121
R. Luo, W. Zhang, A. Kuang, Y. Li
{"title":"Características de imagen poco comunes de la osteomielitis multifocal recurrente crónica en adultos en PET/CT","authors":"R. Luo,&nbsp;W. Zhang,&nbsp;A. Kuang,&nbsp;Y. Li","doi":"10.1016/j.remn.2025.500121","DOIUrl":"10.1016/j.remn.2025.500121","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500121"},"PeriodicalIF":1.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparación de los rendimientos diagnósticos de la gammagrafía de perfusión miocárdica SPECT corregida por atenuación por TC y corregida sin atenuación en la enfermedad de las arterias coronarias 在冠状动脉疾病中,经CT衰减校正和非衰减校正的SPECT心肌灌注造影术的诊断结果比较
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-12 DOI: 10.1016/j.remn.2024.500085
G. Kara Gedik , A. Volkan Çelik , M.U. Yalçın , M. Koplay , F. Yılmaz , H. Önner
<div><h3>Introduction and objectives</h3><div>Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).</div></div><div><h3>Materials and methods</h3><div>Eighty six patients in whom NAC, AC and prone images were obtained with SPECT, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied. Myocardial perfusion scintigraphy was performed using SPECT/CT dual-headed gamma camera. Images were evaluated qualitatively and semi-quantitatively using 20-segment model. Analyzes of global myocardium and LAD, RCA, Cx vascular areas as regional analysis were performed. In qualitative evaluation, if SPECT study was abnormal, relevant coronary artery area was recorded. Quantitative Perfusion SPECT (QPS) program was used in semi-quantitative analysis; Summed Stress Score (SSS)<!--> <!-->≥<!--> <!-->4 was accepted for presence of CAD in per-patient analysis. In regional analysis SSS<!--> <!-->≥<!--> <!-->2 was taken into account. Coronary angiography/CT coronary angiography was used as gold standard. Threshold value was determined as ≥<!--> <!-->50% and above luminal diameter narrowing. While AC and NAC methods were compared for per-patient analysis and each vascular area; 3<!--> <!-->imaging methods including prone acquisition, were compared for the RCA area. Diagnostic performances of the methods were evaluated by comparing the areas under the curve with ROC analysis.</div></div><div><h3>Results</h3><div>In visual evaluation, sensitivity of AC was significantly lower than NAC in analyzes of per-patient, RCA and Cx areas (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%, respectively; <em>P</em> <!--><<!--> <!-->.05). Sensitivity of prone imaging was significantly higher than AC in analysis of the RCA area (76.09% vs 60.87%, respectively; <em>P</em> <!--><<!--> <!-->.05) Specificity values were higher in analyzes of global, RCA and Cx areas in AC than in NAC method; this difference was significant in RCA and Cx areas (RCA 70% vs 42.50%, Cx 85.11% vs 70.21%, respectively; <em>P</em> <!--><<!--> <!-->.05). In semi-quantitative evaluation, AC and NAC had similar sensitivity and specificity in global and regional analyzes; in RCA area, no significant difference was detected between the 3<!--> <!-->methods. In ROC analysis, no significant difference was detected between methods in per-patient and regional analyzes both in visual and semi-quantitative evaluation.</div></div><div><h3>Conclusions</h3><div>CT-based attenuation correction increases specificity, but reduces sensitivity in the diagnosis of CAD in
问题衰减降低了心肌灌注成像单光子发射断层扫描(SPECT)的特异性,导致诊断准确性降低。本研究的目的是比较非衰减校正(NAC)、基于计算机断层扫描的衰减校正(AC)和倾向图像在定性和半定量分析心肌灌注SPECT诊断冠状动脉疾病(CAD)中的表现。材料与方法回顾性分析66例在3个月内完成冠状动脉造影/CT冠状动脉造影并经SPECT获得NAC、AC及俯卧位图像的患者。采用SPECT/CT双头伽马照相机进行心肌灌注显像。采用20段模型对图像进行定性和半定量评价。局部分析整体心肌及LAD、RCA、Cx血管区。定性评价时,如SPECT显像异常,记录相关冠状动脉面积。半定量分析采用定量灌注SPECT (QPS)程序;在每例患者分析中,接受压力总分(SSS)≥4作为存在CAD的标准。在区域分析中,考虑SSS≥2。冠状动脉造影/CT冠状动脉造影为金标准。阈值确定为≥50%及以上的管腔直径变窄。而AC和NAC方法在每个患者和每个血管区域的分析比较;比较了包括俯卧采集在内的3种成像方法对RCA区域的成像效果。通过曲线下面积与ROC分析的比较,评价各方法的诊断效果。结果在目视评价中,AC对单个患者、RCA和Cx区域的敏感性显著低于NAC (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%);P & lt;. 05)。俯卧位成像对RCA区域的敏感度显著高于AC(分别为76.09%和60.87%);P & lt;0.05) AC法的全局、RCA和Cx区特异性值高于NAC法;RCA和Cx区差异显著(RCA分别为70% vs 42.50%, Cx为85.11% vs 70.21%;P & lt;. 05)。在半定量评价中,AC和NAC在全局和区域分析中具有相似的敏感性和特异性;在RCA区,3种方法间差异无统计学意义。在ROC分析中,在目测和半定量评估中,个体分析和区域分析的方法没有发现显著差异。结论基于ct的衰减校正增加了特异性,但降低了RCA和Cx局部区域诊断CAD的敏感性。俯卧位成像仍然是评估RCA区域的重要手段。
{"title":"Comparación de los rendimientos diagnósticos de la gammagrafía de perfusión miocárdica SPECT corregida por atenuación por TC y corregida sin atenuación en la enfermedad de las arterias coronarias","authors":"G. Kara Gedik ,&nbsp;A. Volkan Çelik ,&nbsp;M.U. Yalçın ,&nbsp;M. Koplay ,&nbsp;F. Yılmaz ,&nbsp;H. Önner","doi":"10.1016/j.remn.2024.500085","DOIUrl":"10.1016/j.remn.2024.500085","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction and objectives&lt;/h3&gt;&lt;div&gt;Tissue attenuation reduces the specificity of the myocardial perfusion imaging single photon emission tomography (SPECT), which leads reduced diagnostic accuracy. The aim of this study is to compare performances of non-attenuation corrected (NAC), computed tomography based-attenuation corrected (AC) and prone images for qualitative and semi-quantitative analysis of myocardial perfusion SPECT in diagnosis of coronary artery disease (CAD).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;Eighty six patients in whom NAC, AC and prone images were obtained with SPECT, and whose coronary angiography/CT coronary angiography was completed within 3 months, were retrospectively studied. Myocardial perfusion scintigraphy was performed using SPECT/CT dual-headed gamma camera. Images were evaluated qualitatively and semi-quantitatively using 20-segment model. Analyzes of global myocardium and LAD, RCA, Cx vascular areas as regional analysis were performed. In qualitative evaluation, if SPECT study was abnormal, relevant coronary artery area was recorded. Quantitative Perfusion SPECT (QPS) program was used in semi-quantitative analysis; Summed Stress Score (SSS)&lt;!--&gt; &lt;!--&gt;≥&lt;!--&gt; &lt;!--&gt;4 was accepted for presence of CAD in per-patient analysis. In regional analysis SSS&lt;!--&gt; &lt;!--&gt;≥&lt;!--&gt; &lt;!--&gt;2 was taken into account. Coronary angiography/CT coronary angiography was used as gold standard. Threshold value was determined as ≥&lt;!--&gt; &lt;!--&gt;50% and above luminal diameter narrowing. While AC and NAC methods were compared for per-patient analysis and each vascular area; 3&lt;!--&gt; &lt;!--&gt;imaging methods including prone acquisition, were compared for the RCA area. Diagnostic performances of the methods were evaluated by comparing the areas under the curve with ROC analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;In visual evaluation, sensitivity of AC was significantly lower than NAC in analyzes of per-patient, RCA and Cx areas (global 76.92% vs 86.15%, RCA 60.87% vs 82.61%, Cx 58.97% vs 69.23%, respectively; &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;.05). Sensitivity of prone imaging was significantly higher than AC in analysis of the RCA area (76.09% vs 60.87%, respectively; &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;.05) Specificity values were higher in analyzes of global, RCA and Cx areas in AC than in NAC method; this difference was significant in RCA and Cx areas (RCA 70% vs 42.50%, Cx 85.11% vs 70.21%, respectively; &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;.05). In semi-quantitative evaluation, AC and NAC had similar sensitivity and specificity in global and regional analyzes; in RCA area, no significant difference was detected between the 3&lt;!--&gt; &lt;!--&gt;methods. In ROC analysis, no significant difference was detected between methods in per-patient and regional analyzes both in visual and semi-quantitative evaluation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;CT-based attenuation correction increases specificity, but reduces sensitivity in the diagnosis of CAD in","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500085"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aplicación práctica de la imagen multimodal en la cardio-oncología en América Latina 多模态成像在拉丁美洲心脏肿瘤学中的实际应用
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-12 DOI: 10.1016/j.remn.2024.500086
S. Malhotra , A. Peix , C. Gutierrez-Villamil , M. Bazan , R. Giubbini , C. Cueva , E. Estrada , D. Paez
Latin America is one of the regions in the world with the highest levels of overweight, dyslipidemia, and diabetes mellitus, which, together with smoking and high blood pressure, are common risk factors for cardiovascular and oncological diseases. Chemotherapy (CT) and radiotherapy (RT) have become two of the mainstays of treatment for several types of cancer. One of the most worrisome side effects generated by CT and RT is cardiotoxicity. There are several imaging techniques in cardiology that can inform the presence of underlying disease, but they differ in their availability and access to the masses, their accuracy and repeatability, all of which are important determinants of the applicability of these techniques in routine clinical practice. Thus, it is mandatory to promote a clinically effective and a cost-effective multimodality approach for risk stratification, diagnosis and management of cardiovascular diseases in oncologic patients. The purpose of this review is to inform cardiologists, oncologists, cardio-oncologists and imaging cardiologists on the cardiac imaging modalities that can be applied in patients with cancer, the differences among imaging techniques and recommendations on how to apply them in Latin America.
拉丁美洲是世界上超重、血脂异常和糖尿病发病率最高的地区之一,这些疾病与吸烟和高血压一起是心血管疾病和肿瘤疾病的常见危险因素。化疗(CT)和放疗(RT)已成为几种癌症治疗的两大支柱。CT和RT产生的最令人担忧的副作用之一是心脏毒性。心脏病学中有几种成像技术可以告知潜在疾病的存在,但它们在可获得性和大众可及性、准确性和可重复性方面存在差异,所有这些都是这些技术在常规临床实践中适用性的重要决定因素。因此,必须推广一种临床有效且具有成本效益的多模式方法,以对肿瘤患者的心血管疾病进行风险分层、诊断和管理。本综述的目的是告知心脏病专家、肿瘤学家、心脏肿瘤学家和心脏病成像专家可应用于癌症患者的心脏成像模式、成像技术之间的差异以及如何在拉丁美洲应用这些成像技术的建议。
{"title":"Aplicación práctica de la imagen multimodal en la cardio-oncología en América Latina","authors":"S. Malhotra ,&nbsp;A. Peix ,&nbsp;C. Gutierrez-Villamil ,&nbsp;M. Bazan ,&nbsp;R. Giubbini ,&nbsp;C. Cueva ,&nbsp;E. Estrada ,&nbsp;D. Paez","doi":"10.1016/j.remn.2024.500086","DOIUrl":"10.1016/j.remn.2024.500086","url":null,"abstract":"<div><div>Latin America is one of the regions in the world with the highest levels of overweight, dyslipidemia, and diabetes mellitus, which, together with smoking and high blood pressure, are common risk factors for cardiovascular and oncological diseases. Chemotherapy (CT) and radiotherapy (RT) have become two of the mainstays of treatment for several types of cancer. One of the most worrisome side effects generated by CT and RT is cardiotoxicity. There are several imaging techniques in cardiology that can inform the presence of underlying disease, but they differ in their availability and access to the masses, their accuracy and repeatability, all of which are important determinants of the applicability of these techniques in routine clinical practice. Thus, it is mandatory to promote a clinically effective and a cost-effective multimodality approach for risk stratification, diagnosis and management of cardiovascular diseases in oncologic patients. The purpose of this review is to inform cardiologists, oncologists, cardio-oncologists and imaging cardiologists on the cardiac imaging modalities that can be applied in patients with cancer, the differences among imaging techniques and recommendations on how to apply them in Latin America.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500086"},"PeriodicalIF":1.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metástasis única de melanoma maligno cutáneo en la vesícula biliar detectada con 18F-FDG PET/TC 用18F-FDG PET/TC检测到的胆囊恶性皮肤黑色素瘤单一转移
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-02-05 DOI: 10.1016/j.remn.2025.500120
A. Bota-Bota, M. Pombo-López, I. Martínez-Rodríguez, F. Gómez-de la Fuente, J. Jiménez-Bonilla, R. Quirce
{"title":"Metástasis única de melanoma maligno cutáneo en la vesícula biliar detectada con 18F-FDG PET/TC","authors":"A. Bota-Bota,&nbsp;M. Pombo-López,&nbsp;I. Martínez-Rodríguez,&nbsp;F. Gómez-de la Fuente,&nbsp;J. Jiménez-Bonilla,&nbsp;R. Quirce","doi":"10.1016/j.remn.2025.500120","DOIUrl":"10.1016/j.remn.2025.500120","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500120"},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patrón característico en la PET/TC con [18F]FDG en la encefalitis antirreceptor NMDA NMDA抗受体性脑炎中[18F]FDG的PET/TC特征模式
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-01-18 DOI: 10.1016/j.remn.2024.500084
D.A. López-Mora , L. Lozano Murgas , M. Hervas Pujol , A.A. Rodríguez Revuelto
{"title":"Patrón característico en la PET/TC con [18F]FDG en la encefalitis antirreceptor NMDA","authors":"D.A. López-Mora ,&nbsp;L. Lozano Murgas ,&nbsp;M. Hervas Pujol ,&nbsp;A.A. Rodríguez Revuelto","doi":"10.1016/j.remn.2024.500084","DOIUrl":"10.1016/j.remn.2024.500084","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500084"},"PeriodicalIF":1.6,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Revista Espanola De Medicina Nuclear E Imagen Molecular
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1