Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"El efecto sinérgico de la resonancia magnética multiparamétrica y la imagen PET/TC con [18F]PSMA-1007 en el estudio de la recidiva del adenocarcinoma prostático localmente avanzado","authors":"D. Schmitt , L. Schimmöller , E. Novruzov , J. Kirchner , M. Boschheidgen , E. Mamlins , C. Antke , Y. Mori , G. Antoch , F.L. Giesel","doi":"10.1016/j.remn.2025.500104","DOIUrl":"10.1016/j.remn.2025.500104","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500104"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actualización del procedimiento y guía de interpretación del estudio PET cerebral con 18F-FDG","authors":"C. Vigil Díaz ,&nbsp;P. Paredes Rodríguez ,&nbsp;A. Perissinotti ,&nbsp;E. Fernando Guillén ,&nbsp;D.A. López Mora ,&nbsp;J.A. Lojo Ramírez ,&nbsp;P. Aguiar Fernández ,&nbsp;V. Camacho Martí ,&nbsp;M. Nieves Cabrera-Martín ,&nbsp;por el grupo de Trabajo de Neuroimagen de la SEMNIM","doi":"10.1016/j.remn.2025.500159","DOIUrl":"10.1016/j.remn.2025.500159","url":null,"abstract":"<div><div>The increase in the prevalence of dementia in our clinical setting poses a diagnostic challenge for the Nuclear Medicine specialist. The aim of this study is to review the modifications in the procedure and to describe the usefulness of the use of brain PET with ¹⁸F-FDG in different clinical indications, both classic and emerging ones. The SEMNIM Neuroimaging working group has considered appropriate to update the procedures available in Spanish, in order to optimize the quality of this technique and the interpretation of its findings, both for the specialist in Nuclear Medicine and the rest of the professionals involved in the diagnosis and treatment of neurodegenerative diseases.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500159"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Justificación e impacto del uso de la SPECT 123I-FP-CIT en el diagnóstico diferencial y manejo de los trastornos del movimiento (TM) en un hospital de referencia nacional","authors":"L. Canales Rodríguez ,&nbsp;M. Mitjavila Casanovas ,&nbsp;S. Ruiz Solís","doi":"10.1016/j.remn.2024.500092","DOIUrl":"10.1016/j.remn.2024.500092","url":null,"abstract":"<div><h3>Introduction</h3><div>Cerebral single photon emission computed tomography (SPECT) using ¹²³I-FP-CIT is a key tool in the differential diagnosis of movement disorders (MD), but its appropriate indication is essential to optimize resources and avoid unnecessary tests.</div></div><div><h3>Objective</h3><div>To evaluate the adequacy and impact of SPECT ¹²³I-FP-CIT in the diagnosis and management of MD according to clinical guidelines.</div></div><div><h3>Methodology</h3><div>Retrospective study involving 249 patients with suspected parkinsonism (PK) of uncertain origin. All underwent SPECT ¹²³I-FP-CIT and had a clinical follow-up of exceeding 12 months. Requests were classified based on their adherence to clinical guidelines. Variables analyzed included sex, age, justification for the request, management after SPECT, and final diagnosis.</div></div><div><h3>Results</h3><div>91.57% of the requests were appropriate, while 8.43% did not adhere to the guidelines. Diagnosis changed in 48.6% of cases and management in 70.68% after the scan, especially in inconclusive cases and initiation of therapy. General neurologists evaluated more cases and made more appropriate requests (96,3% vs 76,67%;p<!--> <!-->&lt;<!--> <!-->0,001). However, MD specialists, despite less appropriate use of the text, achieved a higher number of conclusive diagnoses in complex cases.</div></div><div><h3>Conclusion</h3><div>SPECT ¹²³I-FP-CIT has significant clinical impact when used in accordance with clinical guidelines, improving the diagnosis and management of MD. Unjustified scans reduce its utility. Collaboration between general neurologists and MD specialists is fundamental; the latter, although showing less adherence to guidelines in requesting the test, achieve a higher number of conclusive diagnoses in complex cases.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500092"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Una comida sólida hipoalergénica para la gammagrafía de vaciado gástrico basada en la dieta mediterránea. «Una dieta para vaciarlos a todos»","authors":"P. Zaragoza-Ballester ,&nbsp;P. Sarandeses Fernández ,&nbsp;I. González Martín ,&nbsp;C. Martin-Arriscado Arroba ,&nbsp;M.I. Cabanillas Pérez ,&nbsp;X. Guarnizo Poma ,&nbsp;I. Castel de Lucas ,&nbsp;A. Galiana Morón ,&nbsp;D. Vega Pérez ,&nbsp;A.I. Romero Reina ,&nbsp;M.J. Tabuenca Mateo ,&nbsp;S. Ruiz Solís","doi":"10.1016/j.remn.2024.500093","DOIUrl":"10.1016/j.remn.2024.500093","url":null,"abstract":"<div><h3>Aim</h3><div>We aim to establish normal values and standardize a hypoallergenic and Mediterranean diet for gastric emptying scintigraphy (GES).</div></div><div><h3>Material and methods</h3><div>In a prospective cohort of healthy volunteers, we performed GES of a [⁹⁹Tc]TcDTPA²⁻ labelled hypoallergenic meal (egg, potato, rice and olive oil). Anterior and posterior images were simultaneously acquired at 0, 30, 60, 110, 120, 130, 180, 230, 240 and 250<!--> <!-->minutes. Cross-sectional analysis was performed between demographic data and gastric retention values. A score covariance analysis model was used to observer changes between measurements over time.</div></div><div><h3>Results</h3><div>50 participants (29 women) were included. Mean values and standard deviation (5-95th) for gastric retention percentages at 60, 120, 180, 240<!--> <!-->minutes were 51.40<!--> <!-->±<!--> <!-->8.63 (36.5-66.1), 21.66<!--> <!-->±<!--> <!-->9.40 (6.5-38.2), 7.58<!--> <!-->±<!--> <!-->5.77 (1.5-19.1) and 2.94<!--> <!-->±<!--> <!-->2.08 (1-7.3), respectively. Male participants had a significative faster gastric emptying compared to women in practically all the acquisitions. Male participants and smoker participants generated a significative decrease of gastric retention values in generalized linear model (male coefficient −4.818, 95%<!--> <!-->CI: −7.24 to −2.39, <em>P</em> <!-->&lt;<!--> <!-->.001; and smoker coefficient of −3.484, 95%<!--> <!-->CI: −6.29 to −0.67, <em>P</em> <!-->&lt;<!--> <!-->.05).</div></div><div><h3>Conclusion</h3><div>This study standardizes and establishes normal values for GES with the first hypoallergenic solid meal based on consensus recommendations and a Mediterranean diet; suitable for most patients with allergic or sensitive-conditions to other meal components.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500093"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relación entre el estado de HER2 adquirido a partir de los datos patológicos y los parámetros metabólicos obtenidos mediante [18F]FDG PET/TC pretratamiento en adenocarcinomas gástricos","authors":"M.N. Acar Tayyar ,&nbsp;M.Ö. Tamam ,&nbsp;G.B. Babacan ,&nbsp;M.C. Şahin ,&nbsp;H. Özçevik ,&nbsp;S. Şengiz Erhan ,&nbsp;A.E. Öztürk","doi":"10.1016/j.remn.2024.500080","DOIUrl":"10.1016/j.remn.2024.500080","url":null,"abstract":"<div><h3>Objective</h3><div>Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is thought to be more aggressive in gastric cancer. This study aimed to evaluate the predictability of HER2 status and other prognostic pathologic parameters using [¹⁸F]FDG PET/CT and to investigate its impact on survival.</div></div><div><h3>Methods</h3><div>Pretreatment metabolic parameters measured by [¹⁸F]FDG PET/CT as a prognostic factor were retrospectively evaluated in 117 HER2-analysed patients. The relationship between pathological data, tumor metabolic characteristics, and distant metastases was examined, and the effect on survival was investigated.</div></div><div><h3>Results</h3><div>Among the 117 patients, 17.1% were HER2-positive (HER2⁺), and 82.9% were HER2-negative (HER2⁻). There was no significant association between PET/CT parameters in the HER2⁺ and HER2⁻ patient groups. HER2⁺ patients had higher 1- and 3-year survival expectations than HER2⁻ patients (80-37.9%; 47.5-20%; respectively). There was no statistically significant difference in overall survival. In Cox-regression analysis, while the presence of vascular invasion, local invasion, and distant metastasis were poor prognostic factors, HER2 was not a prognostic factor. Vascular invasion and local invasion (T3/T4) were also associated with higher SUVmax values. Patients with distant metastases had significantly higher SUVmax, SUVmean, and TLG.</div></div><div><h3>Conclusion</h3><div>This study showed no association between HER2 expression and [¹⁸F]FDG PET/CT metabolic parameters. However, regardless of HER2 status, the results indicated distant metastasis, local invasion, and vascular invasion could be associated with primary tumor metabolism. PET/CT parameters predict tumor aggressiveness and disease prognosis better than HER2 status.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500080"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estado del arte y perspectivas futuras de nuevos radionúclidos en Medicina Nuclear: Parte III","authors":"I. Torres ,&nbsp;R. Ramos ,&nbsp;M.L. Domínguez ,&nbsp;J.J. Rosales ,&nbsp;A. Roteta ,&nbsp;E. Prieto ,&nbsp;L. Sancho ,&nbsp;M. de Arcocha ,&nbsp;G. Quincoces ,&nbsp;en nombre del Grupo de Oncología de la SEMNIM","doi":"10.1016/j.remn.2025.500161","DOIUrl":"10.1016/j.remn.2025.500161","url":null,"abstract":"<div><div>In this third installment of the continuing education series, the clinical and therapeutic applications of zirconium, astatine and thorium are analyzed in depth. Although they are not described as theragnostic pairs, each of these radionuclides plays a fundamental role in precision medicine, which is rapidly advancing within Nuclear Medicine.</div><div>We begin by analyzing zirconium-89, a positron emitter whose long half-life makes it particularly suitable for labeling large molecules with slow kinetics, such as antibodies, playing a crucial role in immunotherapy. The use of astatine-211, an alpha-emitting radionuclide with a simple decay scheme and chemical behavior similar to iodine, is also discussed. Its main challenge lies in its production, as it requires cyclotrons capable of generating highly energetic alpha particle beams. Furthermore, thorium-227, a 100% alpha emitter, is reviewed. This radionuclide exhibits excellent chelation properties, enabling its conjugation with tumor-targeting molecules to produce thorium-labeled conjugates. While this technique is yielding promising preclinical results, the use of thorium faces challenges, including the potential separation of radium-223 from the molecule and the dependence of activity measurements on the time of production. Since it takes 100 days to reach equilibrium, activity assessment is based on photons emitted by its daughter radionuclides.</div><div>Despite these challenges, these radionuclides are driving the evolution of precision medicine, expanding therapeutic and diagnostic possibilities within Nuclear Medicine.</div><div>Nuclear Medicine.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500161"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefiniendo la localización preoperatoria basada en imágenes de los adenomas en pacientes con hiperparatiroidismo primario candidatos a cirugía mínimamente invasiva","authors":"S. Casanueva-Eliceiry ,&nbsp;M. Manyalich-Blasi ,&nbsp;A. Farré-Melero ,&nbsp;A. Niñerola-Baizán ,&nbsp;D. Saavedra ,&nbsp;M. Mora-Porta ,&nbsp;F.A. Hanzu ,&nbsp;A. Orois ,&nbsp;M. Squarcia ,&nbsp;M. Rodrigo-Calvo ,&nbsp;M. Tormo-Ratera ,&nbsp;K. Quintero-Martinez ,&nbsp;D. Fuster-Pelfort ,&nbsp;O. Vidal-Pérez ,&nbsp;S. Vidal-Sicart","doi":"10.1016/j.remn.2024.500091","DOIUrl":"10.1016/j.remn.2024.500091","url":null,"abstract":"<div><h3>Background and objectives</h3><div>To compare the diagnostic accuracy of [¹⁸F]-Fluorocholine (FCH) PET/CT with conventional [^99mTc]Tc-MIBI scintigraphy and cervical ultrasound (USG) for the preoperative localization of hyperfunctioning parathyroid tissue (HFPT) in patients with primary hyperparathyroidism (PHPT).</div></div><div><h3>Materials and methods</h3><div>This prospective study included 90 patients diagnosed with PHPT who underwent [¹⁸F]F-CH PET/CT, [^99mTc]Tc-MIBI SPECT/CT and Neck USG. The diagnostic accuracy of each imaging modality was assessed using intraoperative findings and histopathological confirmation as the gold standard. The localization accuracy was evaluated based on specific quadrant detection, laterality, and ectopic gland identification. The study also explored the correlation between imaging findings and biochemical parameters, including preoperative and postoperative PTH and calcium levels.</div></div><div><h3>Results</h3><div>[¹⁸F]F-CH PET/CT demonstrated superior accuracy in detecting pathological parathyroid glandscompared to [^99mTc]Tc-MIBI SPECT/CT and USG. [¹⁸F]F-CH PET/CT correctly identified 98.9% of patientswith pathological glands, with a specific location accuracy of 93.2%, 65.9% and 38.8% for [¹⁸F]F-CH PET/CT,[^99mTc]Tc-MIBI SPECT/CT and USG, respectively.</div><div>For ectopic adenomas, FCH PET/CT achieved an accuracy of 100% (4/4), while MIBI and neck ultrasound identified these in 50% (2/4) and 0% (0/4) of cases, respectively.</div><div>There were two cases of multiglandular disease, [¹⁸F]F-CH PET/CT and [99mTc]Tc-MIBI each detected one gland in one case (50%) while USG detected none; in the other case, [¹⁸F]F-CH PET/CT and USG identified both glands (100%), and [99mTc]Tc-MIBI detected none.</div><div>Significant correlations were observed between SUVmax values from [¹⁸F]F-CH PET/CT and gland size, weight, and preoperative PTH levels.</div></div><div><h3>Conclusions</h3><div>[¹⁸F]F-CH PET/CT outperformed conventional imaging modalities in the preoperative localization of HFPT, particularly in challenging cases such ectopic or multiglandular disease. These findings support its potential as an effective and reliable imaging tool for the management of primary hyperparathyroidism.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500091"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMUNICACIONES ORALES (COMUNICACIONES ORALES)","authors":"","doi":"10.1016/S2253-654X(25)00136-2","DOIUrl":"10.1016/S2253-654X(25)00136-2","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 ","pages":"Pages S1-S137"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PÓSTERES (PÓSTERES)","authors":"","doi":"10.1016/S2253-654X(25)00137-4","DOIUrl":"10.1016/S2253-654X(25)00137-4","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 ","pages":"Pages S1-S179"},"PeriodicalIF":1.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malacoplaquia renal y pulmonar con afectación mediastínica que simula en estudio PET/TC con [18F]FDG una neoplasia sincrónica","authors":"J.R. Garcia,&nbsp;A. Compte,&nbsp;S. Romero,&nbsp;L. Mont,&nbsp;L. Pinilla,&nbsp;E. Riera","doi":"10.1016/j.remn.2025.500124","DOIUrl":"10.1016/j.remn.2025.500124","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 3","pages":"Article 500124"},"PeriodicalIF":1.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}