Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"Detección incidental de metástasis óseas de cáncer gástrico en una gammagrafía dinámica renal (renograma) con [99mTc]Tc-DTPA","authors":"C. Nong, Y. Xing, L. Jiang, Z. Zhao","doi":"10.1016/j.remn.2025.500196","DOIUrl":"10.1016/j.remn.2025.500196","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 1","pages":"Article 500196"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto de la infiltración periganglionar en la recurrencia del carcinoma papilar de tiroides","authors":"A. Cinar ,&nbsp;U.M. Turan ,&nbsp;K. Okuyucu ,&nbsp;N. Aydinbelge Dizdar ,&nbsp;A. Erol ,&nbsp;B. Bedi Alpay ,&nbsp;P. Akkus Gunduz ,&nbsp;M. Ozkara ,&nbsp;D. Cayir ,&nbsp;E. Alagoz ,&nbsp;S. Ince","doi":"10.1016/j.remn.2025.500182","DOIUrl":"10.1016/j.remn.2025.500182","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Locoregional recurrence occurs in up to 28% of patients with papillary thyroid cancer (PTC). Several risk factors contribute to this metastatic process. The latest of them is perinodal infiltration (PNI). PNI refers to the pathological extension of tumor cells through the lymph node (LN) capsule into the perinodal fibroadipose tissue. It has been accepted as a poor predictive variable. This study aimed to evaluate the prognostic significance of PNI in recurrence of PTC and identify predictive parameters associated with the recurrence in PNI (+) patients.</div></div><div><h3>Material and methods</h3><div>The study included 680 PTC patients with initial LN metastasis (ILNM). Study population was selected from them according to presence or absence of PNI. Eventually, 102 PNI (+) and 122 PNI (−) patients remained eligible for the study. Patients were statistically compared according to demographic, clinicopathologic features both between PNI (+) and PNI (−) groups and within the PNI (+) group over recurrence status.</div></div><div><h3>Results</h3><div>The recurrence rates were 40% and 15% in PNI (+) and PNI (−) patients, respectively (<em>P</em>&lt;.001). The independent predictive factors associated with recurrence were central ILNM (<em>P</em>=.005), combined central and lateral ILNM (<em>P</em>=.003), ILNM&gt;<!--> <!-->5 (<em>P</em>=.023), stage III-IV (<em>P</em>=.025 and <em>P</em>&lt;.001), tumor size (TS) (<em>P</em>&lt;.001), ILNM size (<em>P</em>&lt;.001), stimulated thyroglobulin (sTg) (<em>P</em>=.039). PNI (<em>P</em>=.05), central ILNM (<em>P</em>=.035) and TS (<em>P</em>=.027) remained prognostic variables after multivariate analysis.</div></div><div><h3>Conclusion</h3><div>PNI positivity is a poor prognostic factor for PTC recurrence. PNI, especially with large TS and central ILNM, should be taken into account when planning RAI therapy in PTC patients.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 1","pages":"Article 500182"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Respuesta a la carta sobre la «Evaluación del papel de la sarcopenia y los parámetros PET/TC con [18F]FDG en el pronóstico del adenocarcinoma ductal de páncreas»","authors":"H. Önner,&nbsp;M.N. Calderon-Tobar,&nbsp;L. Perktaş,&nbsp;F. Yilmaz,&nbsp;G. Kara Gedіk","doi":"10.1016/j.remn.2025.500164","DOIUrl":"10.1016/j.remn.2025.500164","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500164"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación de imágenes de 99mTc-HYNIC-PSMA-11, gammagrafía ósea e investigación posterior a la terapia con radioligandos en los pacientes con CPRCm: experiencia de un solo centro","authors":"K. Aryana ,&nbsp;A. Aghaee ,&nbsp;E. Askari ,&nbsp;Y. Fakhar ,&nbsp;N. Raeisi ,&nbsp;M. Mottaghi ,&nbsp;M. Emadzadeh ,&nbsp;H. Ghorbani ,&nbsp;S Barashki","doi":"10.1016/j.remn.2025.500157","DOIUrl":"10.1016/j.remn.2025.500157","url":null,"abstract":"<div><h3>Background</h3><div>Prostate-Specific Membrane Antigen is overexpressed in primary and metastatic prostate cancer tissues. While PSMA PET agents have gained their role in the prostate cancer guidelines, Technetium-based PSMA agents have left behind. Given the novelty of ^99mTc-HYNIC-PSMA-11, we conducted this study to compare its detection rate in tracing skeletal metastases in comparison to bone scans and also compared the number of metastatic lesions which showed PSMA uptake in the diagnostic scan with those detected in post-treatment scans after radioligand therapy (RLT) with ¹⁷⁷Lu-PSMA-617-617.</div></div><div><h3>Methods</h3><div>Bone and ^99mTc-HYNIC-PSMA-11 scans with a maximum interval of 90 days were performed in thirty-nine patients with widespread bone metastases. If the PSMA scan was positive, patients were treated with ¹⁷⁷Lu-PSMA-617 and post treatment scan was also obtained. For negative PSMA results, ⁶⁸Ga-PSMA PET/CT was performed to compare its results with the bone scan. In patients with PSMA expression, detection of metastatic lesions in three consecutive whole-body scans in different regions were compared (^99mTc-HYNIC-PSMA-11 with bone and post treatment scans, separately).</div></div><div><h3>Results</h3><div>Thirty-seven (94.9%) showed adequate ^99mTc-HYNIC-PSMA-11 uptake in the metastatic regions. Compared to bone scan, ^99mTc-HYNIC-PSMA-11 showed additional lesions in 13 (35.1%) participants which were mostly located in the appendicular skeleton and pelvic bones. Inversely, the bone scan detected more lesions in 12 (32.4%) patients. Both scans in 12 (32.4%) patients showed the exact same results. Comparison between the ^99mTc-HYNIC-PSMA-11 scan and ¹⁷⁷Lu-PSMA-617 showed completely similar results in 29 (78.4%) patients; however, ¹⁷⁷Lu-PSMA-617 detected more lesions in eight (21.6%) participants.</div></div><div><h3>Conclusion</h3><div>The 99mTc-HYNIC-PSMA-11 scan demonstrates comparable results to bone scans in evaluating skeletal metastases in prostate cancer patients. It serves as a cost-effective modality for identifying suitable candidates for radioligand therapy, particularly beneficial in resource-limited countries.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500157"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Puntuaciones semicuantitativas de la MIBG en el neuroblastoma recidivante/refractario: perspectivas pronósticas de la gammagrafía con [131I]MIBG postratamiento e impacto de las imágenes SPECT/TC","authors":"M.E. Mavi ,&nbsp;P. Özgen-Kiratli ,&nbsp;A. Varan ,&nbsp;B. Volkan-Salanci","doi":"10.1016/j.remn.2025.500133","DOIUrl":"10.1016/j.remn.2025.500133","url":null,"abstract":"<div><h3>Objectives</h3><div>Neuroblastoma often demonstrates high uptake of MIBG, which is used for imaging and therapy. This retrospective observational study aimed to assess the prognostic significance of modified Curie scores (mCS) and SIOPEN scores (SS) derived from post-treatment ¹³¹I-MIBG scans in relapsed/refractory neuroblastoma. Additionally, the impact of SPECT/CT imaging on these scores was investigated as a secondary goal.</div></div><div><h3>Material and methods</h3><div>Pediatric patients with relapsed/refractory neuroblastoma, who underwent ¹³¹I-MIBG treatment, were included (n<!--> <!-->=<!--> <!-->35). mCS and SS were calculated from planar images of post-treatment ¹³¹I-MIBG scans. Patients were then categorized based on the cut-off values obtained from these scans, and survival analysis was conducted. To investigate the impact of SPECT/CT imaging on scores, mCS and SS were also calculated from both planar and SPECT/CT images of diagnostic ¹²³I-MIBG scans separately.</div></div><div><h3>Results</h3><div>Patients with mCS<!--> <!-->&gt;12 or SS<!--> <!-->&gt;23 on post-treatment ¹³¹I-MIBG scans had significantly worse overall survival. mCS and SS from SPECT/CT were significantly higher than planar images in pre- and post-treatment diagnostic ¹²³I-MIBG scans. SPECT/CT caused changes in mCS for 61% and SS for 55% of patients, predominantly in axial and appendicular skeleton regions.</div></div><div><h3>Conclusions</h3><div>Both mCS and SS from post-treatment ¹³¹I-MIBG planar scans correlated significantly with overall survival in relapsed/refractory neuroblastoma. Patients with mCS<!--> <!-->&gt;12 or SS<!--> <!-->&gt;23 had poorer survival. SPECT/CT imaging influenced scores for a substantial portion of patients, emphasizing its value alongside planar imaging. Larger, comprehensive studies are warranted to validate these findings and refine prognostic cut-offs. Incorporating SPECT/CT in relevant body regions is recommended for improved disease assessment.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500133"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exactitud diagnóstica del cociente tiroides/fondo para diferenciar la enfermedad de Graves de la tiroiditis subaguda: estudio comparativo","authors":"G. Silov ,&nbsp;F. Bati ,&nbsp;N. Biçakçi ,&nbsp;B. Kirtiloğlu ,&nbsp;M. Yilmaz","doi":"10.1016/j.remn.2025.500199","DOIUrl":"10.1016/j.remn.2025.500199","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background and objective&lt;/h3&gt;&lt;div&gt;Thyrotoxicosis is a common clinical condition in endocrinology, with Graves’ disease (GD) and subacute thyroiditis (SAT) as its predominant causes. These disorders often share overlapping clinical and biochemical features, making differential diagnosis challenging. This study evaluates the diagnostic efficacy of the thyroid/background ratio (TBR) as a semiquantitative method for differentiating GD from SAT and compares multiple diagnostic parameters.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;This was a retrospective analysis of 106 consecutive patients newly diagnosed with thyrotoxicosis. All participants underwent assessment of free tri-iodothyronine (fT3), free thyroxine (fT4), TSH, thyroid-stimulating immunoglobulin (TSI), Anti-TPO, Anti-Tg, CRP, erythrocyte sedimentation rate (ESR), &lt;sup&gt;99m&lt;/sup&gt;Tc thyroid scintigraphy (TS), and ultrasonography (USG). TBR was calculated from TS. Each patient was followed for at least six months, with final diagnoses of GD or SAT made by an endocrinologist.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Sixty-eight and 38 patients were diagnosed with GD and SAT, respectively. The analysis of thyroid-associated laboratory markers and inflammatory indices revealed characteristic differences between GD and SAT. Multivariable logistic regression analysis revealed three independent predictors of SAT: diminished TSI (OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.04; &lt;em&gt;P&lt;/em&gt;=.039), reduced fT3/fT4 ratio (OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.05; &lt;em&gt;P&lt;/em&gt;=.019), and lower TBR (OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.20; &lt;em&gt;P&lt;/em&gt;=.001). TSI demonstrated high diagnostic accuracy area under the curve (AUC): 0.923, optimal cut-off: ≤1.05 IU/L, sensitivity: 100%, specificity: 85.9%). The TBR yielded the highest AUC (0.990) in distinguishing GD from SAT (cut-off: ≤ 3.6 IU/l, sensitivity: 97.4%, specificity: 98.5%).&lt;/div&gt;&lt;div&gt;According to USG findings, the cases showed two different patterns as diffuse thyroiditis pattern (DTP) and nodular thyroiditis pattern (NTP). On USG a DTP was more frequent in GD group than in SAT group (80.9% &lt;em&gt;vs&lt;/em&gt;. 55.3%; &lt;em&gt;P&lt;/em&gt;=.007). In both GD and SAT, demographic and clinical findings were similar between patients with DTP and patients with NTP. However, symptom duration, TSI, fT3, fT3/fT4 ratio, anti-TPO, thyroid ROI and TBR levels were higher in GD patients with DTP or NTP than in SAT patients with DTP or NTP. In contrast, background ROI, ESR and CRP levels were lower. Among patients with DTP, a TBR cut-off value of ≤ 3.7 yielded a sensitivity of 95.2% and a specificity of 98.2% in distinguishing SAT from GD. In this cohort, TBR demonstrated superior diagnostic performance compared to TSI. The optimal TBR threshold for differentiating SAT from GD among patients with NTP was &lt;&lt;!--&gt; &lt;!--&gt;2.3, exhibiting 100% sensitivity and 100% specificity. However, the diagnostic performance was not significantly different from that of TSI. A positive thyroglossal duct activity finding was p","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500199"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma ductal agresivo presentado con superscan mamario bilateral en la [18F]FDG PET/TC","authors":"Ahmed S. Abdlkadir ,&nbsp;Enrique Estrada-Lobato ,&nbsp;Kamal Al-Rabi ,&nbsp;Akram Al-Ibraheem","doi":"10.1016/j.remn.2025.500163","DOIUrl":"10.1016/j.remn.2025.500163","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500163"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El aumento de las tasas de acumulación de [18F]FDG en el cerebro de los niños podría dar lugar a que una menor cantidad de [18F]FDG llegue a otros órganos y tumores: ¿sería necesario un nuevo factor de corrección SUV que tenga en cuenta la captación de [18F]FDG en el cerebro de los niños?","authors":"E. Tatci ,&nbsp;S.B. Schuerrle ,&nbsp;Ö. Özmen","doi":"10.1016/j.remn.2025.500123","DOIUrl":"10.1016/j.remn.2025.500123","url":null,"abstract":"<div><h3>Objective</h3><div>[¹⁸F]FDG uptake in the livers and tumors of children is lower than that of adults. The brain exhibits intense physiological [¹⁸F]FDG uptake. In childhood, the ratio of brain weight to body height and the ratio of brain weight to body weight are higher than those of adults. We hypothesized that in children, most of the [¹⁸F]FDG would be retained in the brain, resulting in less [¹⁸F]FDG activity reaching other organs and tumor tissues.</div></div><div><h3>Methods</h3><div>The [¹⁸F]FDG PET/CT images of 56 pediatric and 24 adult patients were evaluated retrospectively. Patients were divided into four age groups: 1) 3 to 7 years old, 2) 8 to 12 years old, 3) 13 to 17 years old, and 4) over 18 years. Accumulated [¹⁸F]FDG activity in the brain, liver, and whole body (WB) was calculated using the manually drawn volumes of interest for all patients using NUKDOS software. Also, SUV normalized to total body weight (SUVbw) and SUV normalized to lean body mass (SUVlbm) of the liver were calculated using the NUKDOS software.</div></div><div><h3>Results</h3><div>The mean [¹⁸F]FDG accumulation ratio of brain-to-WB was significantly higher in patients aged 3-7 years and 8-12 years than in adults. Brain/WB [¹⁸F]FDG activity ratio was lower in the 13-17 age group compared to the 3-7 age group (<em>P</em>=.0001). The accumulated [¹⁸F]FDG activity ratio of liver-to-WB in the 3-7 age group was significantly lower than in adults when comparing the four groups (<em>P</em>=.0001). The mean of liver SUVbw was statistically lower in the 3-7 and 8-12 age groups than in the 13-17 and adult groups. Patients aged 3-7 years had a significantly lower mean liver SUVlbm than those in the other age groups. The mean liver SUVlbm was also significantly lower in the 8-12 years and 13-17 years age groups than in adults. There was a negative correlation between blood glucose levels and the amount of [¹⁸F]FDG in the brain. However, no statistically significant correlation existed between blood glucose and age.</div></div><div><h3>Conclusion</h3><div>We showed that the [¹⁸F]FDG accumulation rate was higher in the brain and lower in the liver in the children when compared to adults. Our findings suggest that increased uptake of [¹⁸F]FDG in children's brains may lead to reduced activity reaching other organs and tumor tissue. To improve diagnostic accuracy, adapted SUV correction protocols can be developed for pediatric populations, considering age-related changes in [¹⁸F]FDG uptake ratio of the brain.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500123"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estadificación en el cáncer de nasofaringe: valor pronóstico de los parámetros volumétricos de la PET/TC con [18F]FDG","authors":"Ç. Erol ,&nbsp;Ö. Şahin ,&nbsp;G. Kanyılmaz ,&nbsp;S. Erol","doi":"10.1016/j.remn.2025.500160","DOIUrl":"10.1016/j.remn.2025.500160","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of our study was to determine whether volumetric parameters measured from the primary lesion and metastatic lymph node (LN) using [¹⁸F]FDG PET/CT imaging affect prognosis and survival in nasopharyngeal cancer (NPC) patients.</div></div><div><h3>Material and methods</h3><div>Our study included 62 patients diagnosed with NPC who underwent [¹⁸F]FDG PET/CT imaging for pre-treatment staging. SUVmax, SUVmean, MTV and TLG values were measured from the primary tumor and LN. Lymph node/primary tumor SUV ratio (NTR) was calculated. The relationships between volumetric parameters and overall survival (OS), locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS) and progression-free survival (PFS) were evaluated.</div></div><div><h3>Results</h3><div>LN SUVmax and LN SUVmean values were significantly higher in patients with distant metastases (<em>P</em> =.002 and <em>P</em> =.016, respectively). NTR values were significantly higher in patients with distant metastases (<em>P</em>=.047). The ideal LN SUVmax and SUVmean cut-off values for predicting distant metastasis in patients with LN metastasis were 16.45 and 6.5, respectively. There was a statistically significant difference between the DMFSs of the two groups when the NTR cut-off value was 0.8 (<em>P</em>=.047). Multivariate analysis showed that LN SUVmax, LN SUVmean and NTR were associated with DMFS (<em>P</em>=.003, 0.05 and 0.014, respectively), while primary tumor TLG and MTV values were associated with LRRFS (<em>P</em>=.035 and 0.03, respectively).</div></div><div><h3>Conclusion</h3><div>In conclusion, we believe that LN SUVmax, SUVmean and NTR may be prognostic indicators for distant metastasis, and MTV and TLG for locoregional recurrence.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500160"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reacciones adversas mediadas por [99mTc]Tc-tetrofosmina: revisión de la literatura y análisis de informes poscomercialización","authors":"S. Martins ,&nbsp;S. Costa ,&nbsp;M. Sousa ,&nbsp;F. Moreira ,&nbsp;A. Martín-Suaréz ,&nbsp;Â. Jesus","doi":"10.1016/j.remn.2025.500166","DOIUrl":"10.1016/j.remn.2025.500166","url":null,"abstract":"<div><h3>Introduction</h3><div>^99mTc-tetrofosmin is a diagnostic radiopharmaceutical used to evaluate cardiac pathologies. Despite the lower incidence of reactions compared to other drugs, radiopharmaceuticals can still cause adverse reactions. For this reason, pharmacovigilance plays a crucial role in detecting, understanding, evaluating and preventing them.</div></div><div><h3>Objective</h3><div>This study aims to review the available literature, on the safety of ^99mTc-tetrofosmin, and to analyze spontaneous adverse drug reaction reports from the European EudraVigilance database.</div></div><div><h3>Methods</h3><div>A literature review was conducted according to PRISMA methodology. An analysis of spontaneous notifications was carried out in EudraVigilance, until 2022.</div></div><div><h3>Results</h3><div>The review identified a selection of 7 articles. The most reported adverse reactions were skin irritation, strange taste in the mouth and nausea. Regarding the EudraVigilance analysis, 220 notifications were identified, accounting for 477 adverse reactions. The majority belong to males (51%), between 18-64 years (45%). Health professionals were the main reporters (84%). The most prevalent System Organ Class was “general disorders and administration site conditions” (21%) and the most reported adverse reaction was pruritus (10%). Approximately 67% of reactions were considered serious, with 6 fatal cases recorded.</div></div><div><h3>Conclusion</h3><div>The results demonstrated that adverse reactions associated with ^99mTc-tetrofosmin do occur and should not be minimized. Over a period of 17 years, only 220 notifications were recorded, which may highlight potential challenges in pharmacovigilance for radiopharmaceuticals. Therefore, raising awareness about the importance of reporting adverse reactions is crucial.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 6","pages":"Article 500166"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145468896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}