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Rabdomiosarcoma prostático en un paciente de seis años evaluado mediante [18F]FDG PET/TC 通过[18F]FDG PET/CT 评估一名六岁患者的前列腺横纹肌肉瘤
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.remn.2024.500016
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引用次数: 0
Características de la imagen de un angiolipoma espinal atípico en PET/TC y resonancia magnética (RM) 非典型脊柱血管脂肪瘤在 PET/CT 和磁共振成像(MRI)上的成像特征
IF 1.6 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-01 DOI: 10.1016/j.remn.2024.500015
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引用次数: 0
Utilidad de la gammagrafía ósea como reflejo del estado nutritivo del paciente, un caso de escorbuto 骨闪烁成像在反映患者营养状况方面的作用,一个坏血病病例。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.remn.2024.500012
J.A. Vázquez Gómez , M. Salvá Arteaga , I. Roncero Sánchez-Cano , A. Fernández Marín , M.P. Garrastachu Zumarán , M.Y. Ruiz del Prado
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引用次数: 0
Evaluación de la heterogeneidad molecular en tumores neuroendocrinos mediante PET/TC con [68Ga]Ga-DOTA-TOC y [18F]FDG 用[68Ga]Ga-DOTA-TOC 和[18F]FDG PET/CT 评估神经内分泌肿瘤的分子异质性
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.remn.2024.500011
Z. Nogareda Seoane , M.C. Mallón Araújo , A. Calatayud Cubes , C. Barberán Corral , Y. Domínguez Novoa , A. Cousillas Castiñeira , N. Martínez Lago , J.M. de Matías Leralta , V. Pubul Nuñez

Objective

The aim of the study was evaluate the diagnostic performance of [68Ga]Ga-DOTA-TOC and [18F]FDG PET/CT in patients with histologically proven neuroendocrine tumors (NETs), as well as the correlation of the visualized findings with the tumor grade.

Material and methods

We included 50 patients with NETs who underwent both [68Ga]Ga-DOTA-TOC and [18F]FDG PET/TC. The pooled sensitivity of both scans was compared, as well as [68Ga]Ga-DOTA-TOC and [18F]FDG for each tumor grade (grade 1 [G1], grade 2 [G2] and grade 3 [G3]). Also, the sensitivity of [68Ga]Ga-DOTA-TOC and [18F]FDG as a function of the continuous variable Ki-67 was investigated. Finally, the number of lesions detected by both PET radiopharmaceuticals for each tumor grade was compared.

Results

The pooled sensitivity of both PET/CT (96%) was higher than [68Ga]Ga-DOTA-TOC (84%) and [18F]FDG (44%) separately, with statistically significant differences. The sensitivity of [68Ga]Ga-DOTA-TOC was higher than [18F]FDG in both G1 (P = .004) and G2 (P < .001). In G3 the performance of both scans detected disease in 100% of this subgroup. The sensitivity of [68Ga]Ga-DOTA-TOC and [18F]FDG PET/CT correlated significantly with the Ki-67 proliferative index. In G2 patients the number of lesions detected with [68Ga]Ga-DOTA-TOC was higher than [18F]FDG.

Conclusions

The performance of both PET/CT, particularly in G2 and G3, demonstrates the molecular heterogeneity of metastatic NETs and contributes to the selection of a more appropriate treatment, particularly in those high-grade patients who may benefit from radionuclide therapy (PRRT).

研究旨在评估[68Ga]Ga-DOTA-TOC和[18F]FDG PET/CT在组织学证实的神经内分泌肿瘤(NET)患者中的诊断性能,以及显像结果与肿瘤分级的相关性。比较了两种扫描的集合灵敏度,以及[68Ga]Ga-DOTA-TOC和[18F]FDG对各肿瘤分级(1级[G1]、2级[G2]和3级[G3])的灵敏度。此外,还研究了[68Ga]Ga-DOTA-TOC和[18F]FDG的灵敏度与连续变量Ki-67的函数关系。结果 两种 PET/CT 的综合灵敏度(96%)均高于[68Ga]Ga-DOTA-TOC(84%)和[18F]FDG(44%),且差异有统计学意义。在G1(P = .004)和G2(P < .001)中,[68Ga]Ga-DOTA-TOC的灵敏度均高于[18F]FDG。在 G3 组中,两种扫描方法都能在 100%的患者中检测到疾病。68Ga]Ga-DOTA-TOC和[18F]FDG PET/CT的灵敏度与Ki-67增殖指数显著相关。在G2患者中,[68Ga]Ga-DOTA-TOC检测到的病灶数量高于[18F]FDG。结论两种PET/CT的性能,尤其是在G2和G3中的性能,显示了转移性NET的分子异质性,有助于选择更合适的治疗方法,尤其是那些可能从放射性核素治疗(PRRT)中获益的高级别患者。
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引用次数: 0
Detección de salpingitis mediante PET con 18F-FDG en paciente que presenta síndrome febril de origen desconocido 通过 18F-FDG PET 检测一名不明原因发热综合征患者的输卵管炎。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.remn.2024.500010
J.R. Garcia, A. Compte, L. Mont, S. Mourelo, P. Bassa, E. Riera
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引用次数: 0
Análisis radiómico PET intra y peritumoral para predecir la respuesta patológica en pacientes con cáncer de mama que reciben quimioterapia neoadyuvante 用于预测接受新辅助化疗的乳腺癌患者病理反应的瘤内和瘤周 PET 放射线组学分析
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.remn.2024.500002
A. Aksu , Z.G. Güç , K.A. Küçüker , A. Alacacıoğlu , B. Turgut

Objective

The aim of our study was to evaluate the contribution of 18Fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG PET) radiomic data obtained from both the tumoral and peritumoral area in predicting pathological complete response (pCR) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy (NAC).

Methods

Female patients with a diagnosis of invasive ductal carcinoma who received NAC were evaluated retrospectively. The volume of interest (VOI) of the primary tumor (VOI-T) was manually segmented, then a voxel-thick VOI was added around VOI-T to define the peritumoral area (VOI-PT). Morphological, intensity-based, histogram and texture parameters were obtained from VOIs. The patients were divided into two groups as pCR and non-complete pathological response (npCR). A «radiomic model» was created with only radiomic features, and a «patho-radiomic model» was created using radiomic features and immunohistochemical data.

Results

Of the 66 patients included in the study, 21 were in the pCR group. The only statistically significant feature from the primary tumor among patients with pCR and npCR was Morphological_Compacity-T (AUC: 0.666). Between response groups, a significant difference was detected in 2 morphological, 1 intensity, 4 texture features from VOI-PT; no correlation was found between Morphological_Compacity-PT and NGLDM_contrast-PT. The obtained radiomic model's sensitivity and accuracy values were calculated as 61.9% and 75.8%, respectively (AUC: 0.786). When HER2 status was added, sensitivity and accuracy values of the patho-radiomic model increased to 85.7% and 81.8%, respectively (AUC: 0.903).

Conclusions

Evaluation of PET peritumoral radiomic features together with the primary tumor, rather than just the primary tumor, provides a better prediction of the pCR to NAC in patients with breast cancer.

方法对接受新辅助化疗(NAC)的浸润性导管癌女性患者进行回顾性评估。人工分割原发肿瘤的感兴趣体积(VOI)(VOI-T),然后在VOI-T周围添加一个体素厚的VOI来定义瘤周区域(VOI-PT)。根据 VOI 获取形态、基于强度、直方图和纹理参数。患者被分为两组,即 pCR 和非完全病理反应(npCR)。仅利用放射学特征创建 "放射学模型",利用放射学特征和免疫组化数据创建 "病理放射学模型"。在pCR和npCR患者中,唯一具有统计学意义的原发肿瘤特征是Morphological_Compacity-T(AUC:0.666)。在反应组之间,VOI-PT 的 2 个形态特征、1 个强度特征和 4 个纹理特征存在显著差异;Morphological_Compacity-PT 与 NGLDM_contrast-PT 之间没有相关性。计算得出的放射学模型的灵敏度和准确度值分别为 61.9% 和 75.8%(AUC:0.786)。结论与原发肿瘤一起评估 PET 周围肿瘤放射学特征,而不仅仅是原发肿瘤,能更好地预测乳腺癌患者对 NAC 的 pCR。
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引用次数: 0
Valor diagnóstico de la imagen PET/TC con [68Ga]Ga-FAPI en el tumor de células redondas pequeñas desmoplásticas 68Ga]Ga-FAPI PET/CT 成像在脱鳞小圆形细胞瘤中的诊断价值
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.remn.2024.500013
Y. Liu , H. Liu , Z. Wan , Y. Chen , J. Zhang
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引用次数: 0
Desarrollo y validación de un procedimiento alternativo para realizar los controles de pureza radioquímica de radiofármacos de 99mTc con un contador Geiger Müller 开发并验证使用盖革-缪勒计数器对 99mTc 放射性药物进行放射化学纯度控制的替代程序。
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.remn.2024.500006
M.M. Gonzalez , A.L. Poma , N. Cuello , A.L. Soldati

Background and objectives

In a hospital radiopharmacy with 2a operational level, including the preparation of radiopharmaceuticals from prepared and approved reagent kits, it is common to have a single activimeter or dose calibrator for labeling and fractionation, and to perform the quality controls of the 99mTc-radiopharmaceuticals. In certain cases, the accumulation of radioactive material or accidental contamination of the work area causes the background to exceed the limits to carry out the radiochemical purity analyses and it is necessary to look for viable alternatives. In this work, a Geiger Müller detector (equipped with a probe for measuring surface contamination) frequently used for radioprotection purposes, was validated as an alternative and its performance was compared against the activimeter for 99mTc-radiopharmaceuticals.

Materials and methods

Using [99mTc]pertechnetate, systematic studies of error analyses and detector response to activity concentration, activity and measurement time were carried out in liquid matrices and in paper. The results were compared against an activimeter calibrated for [99mTc]Tc.

Results

The developed method was used to determine the radiochemical purity of the compounds [99mTc]Tc-MDP and [99mTc]Tc-MIBI by ascending paper chromatography tests, obtaining comparable values to those measured with an activimeter in the same system (within 1% uncertainty) and using the method of vial partitioning in a dedicated equipment.

Conclusions

This work demonstrates that a Geiger Müller detector with a probe for measuring surface contamination can be adequately used to replace other equipment in the control of radiochemical purity in the hospital radiopharmacy.

背景和目标在一家 2a 级医院的放射药房中,通常使用单一的活度计或剂量校准器进行标记和分馏,并对 99mTc 放射性药物进行质量控制,包括使用已准备好并获得批准的试剂盒制备放射性药物。在某些情况下,放射性物质的积累或工作区域的意外污染会导致本底超出进行放射化学纯度分析的限制,因此有必要寻找可行的替代方法。在这项工作中,对经常用于辐射防护目的的盖革-缪勒探测器(配备有测量表面污染的探头)进行了验证,将其作为一种替代方法,并将其性能与活度计进行了比较,以检测 99mTc 放射性药物。材料和方法使用[99mTc]过硫酸盐,在液体基质和纸张中对误差分析以及探测器对放射性浓度、放射性活度和测量时间的响应进行了系统研究。结果采用所开发的方法,通过上升纸层析测试确定了[99mTc]Tc-MDP 和 [99mTc]Tc-MIBI 化合物的放射化学纯度,获得的数值与在同一系统中使用活度计测量的数值相当(不确定性在 1%以内),并在专用设备中使用了小瓶分隔法。结论这项工作表明,在医院放射药房的放射化学纯度控制中,盖革-缪勒检测器和用于测量表面污染的探头可充分取代其他设备。
{"title":"Desarrollo y validación de un procedimiento alternativo para realizar los controles de pureza radioquímica de radiofármacos de 99mTc con un contador Geiger Müller","authors":"M.M. Gonzalez ,&nbsp;A.L. Poma ,&nbsp;N. Cuello ,&nbsp;A.L. Soldati","doi":"10.1016/j.remn.2024.500006","DOIUrl":"https://doi.org/10.1016/j.remn.2024.500006","url":null,"abstract":"<div><h3>Background and objectives</h3><p>In a hospital radiopharmacy with 2a operational level, including the preparation of radiopharmaceuticals from prepared and approved reagent kits, it is common to have a single activimeter or dose calibrator for labeling and fractionation, and to perform the quality controls of the <sup>99m</sup>Tc-radiopharmaceuticals. In certain cases, the accumulation of radioactive material or accidental contamination of the work area causes the background to exceed the limits to carry out the radiochemical purity analyses and it is necessary to look for viable alternatives. In this work, a Geiger Müller detector (equipped with a probe for measuring surface contamination) frequently used for radioprotection purposes, was validated as an alternative and its performance was compared against the activimeter for <sup>99m</sup>Tc-radiopharmaceuticals.</p></div><div><h3>Materials and methods</h3><p>Using [<sup>99m</sup>Tc]pertechnetate, systematic studies of error analyses and detector response to activity concentration, activity and measurement time were carried out in liquid matrices and in paper. The results were compared against an activimeter calibrated for [<sup>99m</sup>Tc]Tc.</p></div><div><h3>Results</h3><p>The developed method was used to determine the radiochemical purity of the compounds [<sup>99m</sup>Tc]Tc-MDP and [<sup>99m</sup>Tc]Tc-MIBI by ascending paper chromatography tests, obtaining comparable values to those measured with an activimeter in the same system (within 1% uncertainty) and using the method of vial partitioning in a dedicated equipment.</p></div><div><h3>Conclusions</h3><p>This work demonstrates that a Geiger Müller detector with a probe for measuring surface contamination can be adequately used to replace other equipment in the control of radiochemical purity in the hospital radiopharmacy.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141073173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osificación de la hoz del cerebro en cáncer de mama metastásico 转移性乳腺癌的脑镰状骨化
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.remn.2024.500001
S. de la Torre Fernández, M.J. Tello Galán, B. Aradas Cabado, A.E. Seva Delgado, C.M. Hernández Heredia, A.J. Fernández Sánchez
{"title":"Osificación de la hoz del cerebro en cáncer de mama metastásico","authors":"S. de la Torre Fernández,&nbsp;M.J. Tello Galán,&nbsp;B. Aradas Cabado,&nbsp;A.E. Seva Delgado,&nbsp;C.M. Hernández Heredia,&nbsp;A.J. Fernández Sánchez","doi":"10.1016/j.remn.2024.500001","DOIUrl":"10.1016/j.remn.2024.500001","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valor añadido de la PET/TC con [18F]fluorocolina en la valoración del hiperparatiroidismo secundario o terciario [18F]氟胆碱 PET/CT 在评估二级或三级甲状旁腺机能亢进症中的附加价值
IF 1.2 4区 医学 Q3 Medicine Pub Date : 2024-05-01 DOI: 10.1016/j.remn.2024.500005
S. Abouzian , D.A. López-Mora , A. Fernández-León , C. Facundo , P. Stefaneli , A. Flotats
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引用次数: 0
期刊
Revista Espanola De Medicina Nuclear E Imagen Molecular
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