Pub Date : 2024-07-01DOI: 10.1016/j.remn.2024.500016
{"title":"Rabdomiosarcoma prostático en un paciente de seis años evaluado mediante [18F]FDG PET/TC","authors":"","doi":"10.1016/j.remn.2024.500016","DOIUrl":"10.1016/j.remn.2024.500016","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141415622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.remn.2024.500015
{"title":"Características de la imagen de un angiolipoma espinal atípico en PET/TC y resonancia magnética (RM)","authors":"","doi":"10.1016/j.remn.2024.500015","DOIUrl":"10.1016/j.remn.2024.500015","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/j.remn.2024.500012
J.A. Vázquez Gómez , M. Salvá Arteaga , I. Roncero Sánchez-Cano , A. Fernández Marín , M.P. Garrastachu Zumarán , M.Y. Ruiz del Prado
{"title":"Utilidad de la gammagrafía ósea como reflejo del estado nutritivo del paciente, un caso de escorbuto","authors":"J.A. Vázquez Gómez , M. Salvá Arteaga , I. Roncero Sánchez-Cano , A. Fernández Marín , M.P. Garrastachu Zumarán , M.Y. Ruiz del Prado","doi":"10.1016/j.remn.2024.500012","DOIUrl":"https://doi.org/10.1016/j.remn.2024.500012","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/j.remn.2024.500011
Z. Nogareda Seoane , M.C. Mallón Araújo , A. Calatayud Cubes , C. Barberán Corral , Y. Domínguez Novoa , A. Cousillas Castiñeira , N. Martínez Lago , J.M. de Matías Leralta , V. Pubul Nuñez
Objective
The aim of the study was evaluate the diagnostic performance of [68Ga]Ga-DOTA-TOC and [18F]FDG PET/CT in patients with histologically proven neuroendocrine tumors (NETs), as well as the correlation of the visualized findings with the tumor grade.
Material and methods
We included 50 patients with NETs who underwent both [68Ga]Ga-DOTA-TOC and [18F]FDG PET/TC. The pooled sensitivity of both scans was compared, as well as [68Ga]Ga-DOTA-TOC and [18F]FDG for each tumor grade (grade 1 [G1], grade 2 [G2] and grade 3 [G3]). Also, the sensitivity of [68Ga]Ga-DOTA-TOC and [18F]FDG as a function of the continuous variable Ki-67 was investigated. Finally, the number of lesions detected by both PET radiopharmaceuticals for each tumor grade was compared.
Results
The pooled sensitivity of both PET/CT (96%) was higher than [68Ga]Ga-DOTA-TOC (84%) and [18F]FDG (44%) separately, with statistically significant differences. The sensitivity of [68Ga]Ga-DOTA-TOC was higher than [18F]FDG in both G1 (P = .004) and G2 (P < .001). In G3 the performance of both scans detected disease in 100% of this subgroup. The sensitivity of [68Ga]Ga-DOTA-TOC and [18F]FDG PET/CT correlated significantly with the Ki-67 proliferative index. In G2 patients the number of lesions detected with [68Ga]Ga-DOTA-TOC was higher than [18F]FDG.
Conclusions
The performance of both PET/CT, particularly in G2 and G3, demonstrates the molecular heterogeneity of metastatic NETs and contributes to the selection of a more appropriate treatment, particularly in those high-grade patients who may benefit from radionuclide therapy (PRRT).
{"title":"Evaluación de la heterogeneidad molecular en tumores neuroendocrinos mediante PET/TC con [68Ga]Ga-DOTA-TOC y [18F]FDG","authors":"Z. Nogareda Seoane , M.C. Mallón Araújo , A. Calatayud Cubes , C. Barberán Corral , Y. Domínguez Novoa , A. Cousillas Castiñeira , N. Martínez Lago , J.M. de Matías Leralta , V. Pubul Nuñez","doi":"10.1016/j.remn.2024.500011","DOIUrl":"https://doi.org/10.1016/j.remn.2024.500011","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of the study was evaluate the diagnostic performance of [<sup>68</sup>Ga]Ga-DOTA-TOC and [<sup>18</sup>F]FDG PET/CT in patients with histologically proven neuroendocrine tumors (NETs), as well as the correlation of the visualized findings with the tumor grade.</p></div><div><h3>Material and methods</h3><p>We included 50 patients with NETs who underwent both [<sup>68</sup>Ga]Ga-DOTA-TOC and [<sup>18</sup>F]FDG PET/TC. The pooled sensitivity of both scans was compared, as well as [<sup>68</sup>Ga]Ga-DOTA-TOC and [<sup>18</sup>F]FDG for each tumor grade (grade<!--> <!-->1 [G1], grade<!--> <!-->2 [G2] and grade<!--> <!-->3 [G3]). Also, the sensitivity of [<sup>68</sup>Ga]Ga-DOTA-TOC and [<sup>18</sup>F]FDG as a function of the continuous variable Ki-67 was investigated. Finally, the number of lesions detected by both PET radiopharmaceuticals for each tumor grade was compared.</p></div><div><h3>Results</h3><p>The pooled sensitivity of both PET/CT (96%) was higher than [<sup>68</sup>Ga]Ga-DOTA-TOC (84%) and [<sup>18</sup>F]FDG (44%) separately, with statistically significant differences. The sensitivity of [<sup>68</sup>Ga]Ga-DOTA-TOC was higher than [<sup>18</sup>F]FDG in both G1 (<em>P</em> <!-->=<!--> <!-->.004) and G2 (<em>P</em> <!--><<!--> <!-->.001). In G3 the performance of both scans detected disease in 100% of this subgroup. The sensitivity of [<sup>68</sup>Ga]Ga-DOTA-TOC and [<sup>18</sup>F]FDG PET/CT correlated significantly with the Ki-67 proliferative index. In G2 patients the number of lesions detected with [<sup>68</sup>Ga]Ga-DOTA-TOC was higher than [<sup>18</sup>F]FDG.</p></div><div><h3>Conclusions</h3><p>The performance of both PET/CT, particularly in G2 and G3, demonstrates the molecular heterogeneity of metastatic NETs and contributes to the selection of a more appropriate treatment, particularly in those high-grade patients who may benefit from radionuclide therapy (PRRT).</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141073174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/j.remn.2024.500010
J.R. Garcia, A. Compte, L. Mont, S. Mourelo, P. Bassa, E. Riera
{"title":"Detección de salpingitis mediante PET con 18F-FDG en paciente que presenta síndrome febril de origen desconocido","authors":"J.R. Garcia, A. Compte, L. Mont, S. Mourelo, P. Bassa, E. Riera","doi":"10.1016/j.remn.2024.500010","DOIUrl":"10.1016/j.remn.2024.500010","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141026485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/j.remn.2024.500002
A. Aksu , Z.G. Güç , K.A. Küçüker , A. Alacacıoğlu , B. Turgut
Objective
The aim of our study was to evaluate the contribution of 18Fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG PET) radiomic data obtained from both the tumoral and peritumoral area in predicting pathological complete response (pCR) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy (NAC).
Methods
Female patients with a diagnosis of invasive ductal carcinoma who received NAC were evaluated retrospectively. The volume of interest (VOI) of the primary tumor (VOI-T) was manually segmented, then a voxel-thick VOI was added around VOI-T to define the peritumoral area (VOI-PT). Morphological, intensity-based, histogram and texture parameters were obtained from VOIs. The patients were divided into two groups as pCR and non-complete pathological response (npCR). A «radiomic model» was created with only radiomic features, and a «patho-radiomic model» was created using radiomic features and immunohistochemical data.
Results
Of the 66 patients included in the study, 21 were in the pCR group. The only statistically significant feature from the primary tumor among patients with pCR and npCR was Morphological_Compacity-T (AUC: 0.666). Between response groups, a significant difference was detected in 2 morphological, 1 intensity, 4 texture features from VOI-PT; no correlation was found between Morphological_Compacity-PT and NGLDM_contrast-PT. The obtained radiomic model's sensitivity and accuracy values were calculated as 61.9% and 75.8%, respectively (AUC: 0.786). When HER2 status was added, sensitivity and accuracy values of the patho-radiomic model increased to 85.7% and 81.8%, respectively (AUC: 0.903).
Conclusions
Evaluation of PET peritumoral radiomic features together with the primary tumor, rather than just the primary tumor, provides a better prediction of the pCR to NAC in patients with breast cancer.
{"title":"Análisis radiómico PET intra y peritumoral para predecir la respuesta patológica en pacientes con cáncer de mama que reciben quimioterapia neoadyuvante","authors":"A. Aksu , Z.G. Güç , K.A. Küçüker , A. Alacacıoğlu , B. Turgut","doi":"10.1016/j.remn.2024.500002","DOIUrl":"https://doi.org/10.1016/j.remn.2024.500002","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of our study was to evaluate the contribution of <sup>18</sup>Fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG PET) radiomic data obtained from both the tumoral and peritumoral area in predicting pathological complete response (pCR) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy (NAC).</p></div><div><h3>Methods</h3><p>Female patients with a diagnosis of invasive ductal carcinoma who received NAC were evaluated retrospectively. The volume of interest (VOI) of the primary tumor (VOI-<sub>T</sub>) was manually segmented, then a voxel-thick VOI was added around VOI-<sub>T</sub> to define the peritumoral area (VOI-<sub>PT</sub>). Morphological, intensity-based, histogram and texture parameters were obtained from VOIs. The patients were divided into two groups as pCR and non-complete pathological response (npCR). A «radiomic model» was created with only radiomic features, and a «patho-radiomic model» was created using radiomic features and immunohistochemical data.</p></div><div><h3>Results</h3><p>Of the 66 patients included in the study, 21 were in the pCR group. The only statistically significant feature from the primary tumor among patients with pCR and npCR was Morphological_Compacity-<sub>T</sub> (AUC: 0.666). Between response groups, a significant difference was detected in 2 morphological, 1 intensity, 4 texture features from VOI-<sub>PT</sub>; no correlation was found between Morphological_Compacity-<sub>PT</sub> and NGLDM_contrast-<sub>PT</sub>. The obtained radiomic model's sensitivity and accuracy values were calculated as 61.9% and 75.8%, respectively (AUC: 0.786). When HER2 status was added, sensitivity and accuracy values of the patho-radiomic model increased to 85.7% and 81.8%, respectively (AUC: 0.903).</p></div><div><h3>Conclusions</h3><p>Evaluation of PET peritumoral radiomic features together with the primary tumor, rather than just the primary tumor, provides a better prediction of the pCR to NAC in patients with breast cancer.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141073161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/j.remn.2024.500013
Y. Liu , H. Liu , Z. Wan , Y. Chen , J. Zhang
{"title":"Valor diagnóstico de la imagen PET/TC con [68Ga]Ga-FAPI en el tumor de células redondas pequeñas desmoplásticas","authors":"Y. Liu , H. Liu , Z. Wan , Y. Chen , J. Zhang","doi":"10.1016/j.remn.2024.500013","DOIUrl":"10.1016/j.remn.2024.500013","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2253654X24000209/pdfft?md5=3c33e724fb5728ac25df5b275aad77fd&pid=1-s2.0-S2253654X24000209-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141056832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In a hospital radiopharmacy with 2a operational level, including the preparation of radiopharmaceuticals from prepared and approved reagent kits, it is common to have a single activimeter or dose calibrator for labeling and fractionation, and to perform the quality controls of the 99mTc-radiopharmaceuticals. In certain cases, the accumulation of radioactive material or accidental contamination of the work area causes the background to exceed the limits to carry out the radiochemical purity analyses and it is necessary to look for viable alternatives. In this work, a Geiger Müller detector (equipped with a probe for measuring surface contamination) frequently used for radioprotection purposes, was validated as an alternative and its performance was compared against the activimeter for 99mTc-radiopharmaceuticals.
Materials and methods
Using [99mTc]pertechnetate, systematic studies of error analyses and detector response to activity concentration, activity and measurement time were carried out in liquid matrices and in paper. The results were compared against an activimeter calibrated for [99mTc]Tc.
Results
The developed method was used to determine the radiochemical purity of the compounds [99mTc]Tc-MDP and [99mTc]Tc-MIBI by ascending paper chromatography tests, obtaining comparable values to those measured with an activimeter in the same system (within 1% uncertainty) and using the method of vial partitioning in a dedicated equipment.
Conclusions
This work demonstrates that a Geiger Müller detector with a probe for measuring surface contamination can be adequately used to replace other equipment in the control of radiochemical purity in the hospital radiopharmacy.
{"title":"Desarrollo y validación de un procedimiento alternativo para realizar los controles de pureza radioquímica de radiofármacos de 99mTc con un contador Geiger Müller","authors":"M.M. Gonzalez , A.L. Poma , N. Cuello , A.L. Soldati","doi":"10.1016/j.remn.2024.500006","DOIUrl":"https://doi.org/10.1016/j.remn.2024.500006","url":null,"abstract":"<div><h3>Background and objectives</h3><p>In a hospital radiopharmacy with 2a operational level, including the preparation of radiopharmaceuticals from prepared and approved reagent kits, it is common to have a single activimeter or dose calibrator for labeling and fractionation, and to perform the quality controls of the <sup>99m</sup>Tc-radiopharmaceuticals. In certain cases, the accumulation of radioactive material or accidental contamination of the work area causes the background to exceed the limits to carry out the radiochemical purity analyses and it is necessary to look for viable alternatives. In this work, a Geiger Müller detector (equipped with a probe for measuring surface contamination) frequently used for radioprotection purposes, was validated as an alternative and its performance was compared against the activimeter for <sup>99m</sup>Tc-radiopharmaceuticals.</p></div><div><h3>Materials and methods</h3><p>Using [<sup>99m</sup>Tc]pertechnetate, systematic studies of error analyses and detector response to activity concentration, activity and measurement time were carried out in liquid matrices and in paper. The results were compared against an activimeter calibrated for [<sup>99m</sup>Tc]Tc.</p></div><div><h3>Results</h3><p>The developed method was used to determine the radiochemical purity of the compounds [<sup>99m</sup>Tc]Tc-MDP and [<sup>99m</sup>Tc]Tc-MIBI by ascending paper chromatography tests, obtaining comparable values to those measured with an activimeter in the same system (within 1% uncertainty) and using the method of vial partitioning in a dedicated equipment.</p></div><div><h3>Conclusions</h3><p>This work demonstrates that a Geiger Müller detector with a probe for measuring surface contamination can be adequately used to replace other equipment in the control of radiochemical purity in the hospital radiopharmacy.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141073173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/j.remn.2024.500001
S. de la Torre Fernández, M.J. Tello Galán, B. Aradas Cabado, A.E. Seva Delgado, C.M. Hernández Heredia, A.J. Fernández Sánchez
{"title":"Osificación de la hoz del cerebro en cáncer de mama metastásico","authors":"S. de la Torre Fernández, M.J. Tello Galán, B. Aradas Cabado, A.E. Seva Delgado, C.M. Hernández Heredia, A.J. Fernández Sánchez","doi":"10.1016/j.remn.2024.500001","DOIUrl":"10.1016/j.remn.2024.500001","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/j.remn.2024.500005
S. Abouzian , D.A. López-Mora , A. Fernández-León , C. Facundo , P. Stefaneli , A. Flotats
{"title":"Valor añadido de la PET/TC con [18F]fluorocolina en la valoración del hiperparatiroidismo secundario o terciario","authors":"S. Abouzian , D.A. López-Mora , A. Fernández-León , C. Facundo , P. Stefaneli , A. Flotats","doi":"10.1016/j.remn.2024.500005","DOIUrl":"https://doi.org/10.1016/j.remn.2024.500005","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}