Contact Lens & Anterior Eye最新文献_第4页

Effects of eyelid pressure on corneal tomography and biomechanics: Quantitative analysis using a novel blepharo-tensiometer 眼睑压力对角膜断层成像和生物力学的影响：使用新型眼睑张力计进行定量分析。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-10-09 DOI: 10.1016/j.clae.2024.102313

Meng Lin , Jian Zhao , Xueli Shao , Hongqing Ma , Yadong Huang , Zhengqian Fang , Zhiqiang Xu , Kan Lin , Kechun Liu , Jia Qu , Fan Lu , Liang Hu

Purpose

This study aimed to validate a blepharo-tensiometer, and investigate the relationship between eyelid pressure (ELP) and corneal tomography/biomechanics.

Methods

Repeatability of the blepharo-tensiometer was evaluated at different inclination angles: 10°, 15°, and 20° for the upper eyelid (U10, U15, and U20) and 45°, 50°, and 55° for the lower eyelid (L45, L50, and L55). Reproducibility was evaluated in terms of different operators and inclination angles. Both the maximum and average ELP were evaluated. Best-corrected visual acuity, manifest refraction spherical equivalent, eyelid types, palpebral fissure height, exophthalmometry, axial length, and corneal tomographic/biomechanical parameters were measured. Spearman analysis and generalized estimating equations were used to explore potential correlations.

Results

This study included 36 eyes from 36 subjects. The ICCs for repeatability were comparable between different inclination angles, so U15 and L50 were selected for further analysis. The ICCs for reproducibility in terms of different operator or inclination angle also achieved good to excellent outcomes. Certain associations have been revealed between the ELP and corneal tomographic/biomechanical parameters. Tomographically, ELP influences corneal front J0, front asphericity, and the index of surface variance; whereas biomechanically, ELP affects the time at first applanation, deformation amplitude at highest concavity, and biomechanically corrected intraocular pressure.

Conclusions

The tensiometer showed good precision. The study also showed that ELP causes a flattening effect on the peripheral cornea, with greater ELP linked to better corneal biomechanical properties in healthy subjects. These findings may potentially illuminate new avenues in the field of corneal disorders and beyond.

目的：本研究旨在验证眼睑张力计，并调查眼睑压力（ELP）与角膜断层扫描/生物力学之间的关系：在不同的倾斜角度下对眼睑张力计的重复性进行了评估：上眼睑（U10、U15 和 U20）为 10°、15° 和 20°，下眼睑（L45、L50 和 L55）为 45°、50° 和 55°。根据不同的操作者和倾斜角度对再现性进行了评估。对最大和平均 ELP 都进行了评估。此外，还测量了最佳矫正视力、球面等效屈光度、眼睑类型、睑裂高度、眼球外径、轴向长度和角膜层析成像/生物力学参数。采用斯皮尔曼分析法和广义估计方程来探讨潜在的相关性：本研究包括 36 名受试者的 36 只眼睛。不同倾斜角度的重复性 ICC 值相当，因此选择 U15 和 L50 进行进一步分析。不同操作者或倾斜角度的重复性 ICC 也达到了良好到优秀的结果。ELP与角膜断层成像/生物力学参数之间存在某些关联。在断层扫描上，ELP 影响角膜前方 J0、前方非球面度和表面差异指数；而在生物力学上，ELP 影响首次角膜塑形时间、最高凹处的变形幅度和生物力学校正眼压：张力计显示出良好的精确性。研究还表明，ELP 会导致周边角膜变平，ELP 越大，健康受试者的角膜生物力学特性越好。这些发现有可能为角膜疾病及其他领域的研究开辟新的道路。

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引用次数: 0

Potential pro-inflammatory impact of scleral lens midday fogging on human corneal epithelial cells: An in vitro study. 巩膜透镜正午雾化对人类角膜上皮细胞的潜在促炎影响：体外研究。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-10-01 Epub Date: 2024-05-17 DOI: 10.1016/j.clae.2024.102187

Maria K Walker, Carolina Lema, Rachel Redfern

Purpose: Midday fogging (MDF) occurs when particulate material accumulates in the fluid reservoir (FR) beneath scleral lenses (SL), and its impact on epithelial cells is unknown. This study examines the in vitro pro-inflammatory effect of the FR on human corneal epithelial cells in varying degrees of MDF.

Methods: Normal SL neophytes were recruited to wear SL 8 h daily for 4 days. Following 8 h on days 1 and 4, optical coherence tomography (OCT) images were acquired for MDF quantification using ImageJ, and the FR was collected. FR samples from the same eye were later pooled, diluted 2-fold and applied on human telomerase-immortalized corneal epithelial (hTCEpi) cells cultured on Terasaki microwell plates. Tumor necrosis factor (TNF)-α and culture media were used as positive and negative controls, respectively. After a 30-minute treatment, the nuclear factor-kappa B (NF-κB) pathway was measured by NF-κB-p65 immunofluorescence and images were analyzed with ImageJ. Pearson's correlation was conducted to determine the association between median nuclear fluorescence and MDF.

Results: Fourteen FR samples with a mean volume of 22 ± 16 µl were tested. Mean MDF severity following 8 h of SL wear was 25 ± 17 units (range 7 - 64). The median nuclear fluorescence (NF-κB-p65 translocation) in cultured hTCEpi cells ranged from 31.43 to 45.16 while the negative and positive controls were 44.71 ± 1.72 and 108.77 ± 68.38, respectively. Although a potential positive trend between MDF and median nuclear fluorescence was observed, Pearson's correlation analysis revealed no significant association (r = +0.48, P = 0.09).

Conclusions: The results suggest that the FR can trigger NF-κB-p65 translocation in hTCEpi cells, which may be associated with MDF severity. This study introduces the use of Terasaki microwell plates for immunofluorescence studies of the FR. The technique is simple, minimizes sample usage, and does not require expensive instrumentation.

目的：巩膜晶体（SL）下的储液器（FR）中积聚颗粒物质时，就会发生中午起雾（MDF）现象，其对角膜上皮细胞的影响尚不清楚。本研究探讨了在不同程度的 MDF 情况下，FR 对人类角膜上皮细胞的体外促炎作用：方法：招募正常的角膜塑形镜新手，每天佩戴角膜塑形镜 8 小时，连续 4 天。在第 1 天和第 4 天佩戴 8 小时后，使用 ImageJ 采集光学相干断层扫描（OCT）图像以量化 MDF，并采集 FR。随后将同一只眼睛的 FR 样品集中起来，稀释 2 倍，并应用于在 Terasaki 微孔板上培养的人端粒酶永久化角膜上皮细胞（hTCEpi）。肿瘤坏死因子（TNF）-α 和培养基分别作为阳性和阴性对照。处理 30 分钟后，用 NF-κB-p65 免疫荧光法测定核因子-kappa B（NF-κB）通路，并用 ImageJ 分析图像。通过皮尔逊相关性来确定核荧光中位数与 MDF 之间的关联：测试了 14 份平均体积为 22 ± 16 µl 的 FR 样品。佩戴 SL 8 小时后，MDF 的平均严重程度为 25 ± 17 单位（范围为 7 - 64）。在培养的 hTCEpi 细胞中，核荧光（NF-κB-p65 转位）的中位数为 31.43 至 45.16，而阴性和阳性对照组分别为 44.71 ± 1.72 和 108.77 ± 68.38。虽然观察到 MDF 与核荧光中位数之间存在潜在的正相关趋势，但皮尔逊相关分析显示两者之间没有显著关联（r = +0.48，P = 0.09）：结果表明，FR 可触发 NF-κB-p65 在 hTCEpi 细胞中的转位，这可能与 MDF 的严重程度有关。本研究介绍了使用寺崎微孔板对 FR 进行免疫荧光研究的方法。该技术操作简单，样本用量最少，而且不需要昂贵的仪器。

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引用次数: 0

Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment. 正视镜治疗 1 年期间儿童脉络膜血管的动态变化及其与近视控制效果的关系。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-09-29 DOI: 10.1016/j.clae.2024.102314

Mengqi Liu, Jing Huang, Zhu Xie, Yuanyuan Wang, Pengqi Wang, Ruijing Xia, Xinting Liu, Binbin Su, Jia Qu, Xiangtian Zhou, Xinjie Mao, Hao Wu

Purpose: To investigate the dynamic changes of choroidal vasculature and its association in mediating ocular elongation over 1 year of orthokeratology (ortho-k) treatment.

Methods: This observational study included 8-14 year old myopic children who were willing to receive ortho-k treatment or wear single vision spectacle lenses (SVL). Axial length (AL) and choroidal characteristics, including submacular luminal area (LA), stromal area (SA), total choroidal area (TCA), choroidal vascularity index (CVI), subfoveal choroidal thickness (SFCT) and choriocapillaris flow deficits (CcFD) from OCT/OCTA images, were evaluated at baseline, 3, 6 and 12 months.

Results: After 1 year, AL elongation was significantly less in 25 children treated with ortho-k than in 29 children wearing SVL (0.17 ± 0.14 v.s. 0.28 ± 0.16 mm, P<0.01). In the ortho-k group, LA, SA, TCA and SFCT were significantly increased by 0.033 ± 0.059 mm², 0.024 ± 0.035 mm², 0.058 ± 0.087 mm², 8.9 ± 17.4 μm, respectively, at 3 months (all P<0.05). These parameters returned to near baseline levels over the following 9 months. Meanwhile, CcFD decreased by 0.83 ± 1.09 % over 12 months, but CVI remained steady during this period. No significant changes in these choroidal parameters (except for CcFD, decreased by -0.56 ± 1.23 %) were observed in the SVL group over 12 months. Increases in SFCT, LA, SA and TCA over 12 months were significantly greater in the ortho-k group than in the SVL group. Mediation analyses showed that 44.8 % of effect on inhibiting AL elongation through ortho-k was mediated via TCA (in particular LA).

Conclusions: The decelerated ocular elongation during ortho-k treatment is accompanied by increases in content of choroidal vascular lumen and stromal component. Dynamic changes of choroidal vasculature provide a possible mechanism underlying myopia control efficacy via ortho-k.

目的：研究正角膜塑形镜（ortho-k）治疗一年来脉络膜血管的动态变化及其与眼球伸长的关联：这项观察性研究纳入了愿意接受角膜矫形治疗或配戴单光眼镜（SVL）的8-14岁近视儿童。在基线、3个月、6个月和12个月时，对轴向长度（AL）和脉络膜特征进行评估，包括脉络膜下腔面积（LA）、基质面积（SA）、脉络膜总面积（TCA）、脉络膜血管指数（CVI）、眼底脉络膜厚度（SFCT）和OCT/OCTA图像显示的脉络膜瓣血流缺损（CcFD）：结果：1年后，25名接受ortho-k治疗的儿童的AL伸长率明显低于29名接受SVL治疗的儿童（3个月时分别为0.17 ± 0.14 v.s. 0.28 ± 0.16 mm, P2, 0.024 ± 0.035 mm2, 0.058 ± 0.087 mm2, 8.9 ± 17.4 μm）：在正钾治疗期间，眼球伸长速度减慢，同时脉络膜血管腔和基质成分含量增加。脉络膜血管的动态变化提供了通过角膜矫形器有效控制近视的可能机制。

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引用次数: 0

Lid wiper epitheliopathy: Topical review of current identification strategies and future perspectives 睑板腺上皮病变：当前识别策略和未来展望的专题回顾。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-09-23 DOI: 10.1016/j.clae.2024.102312

Anitha Arvind , Rakesh Nanjappa , Krishna Kumar Gupta , Rute J. Macedo-de-Araújo , Daddi Fadel

Lid Wiper Epitheliopathy (LWE) is a recognized ocular condition affecting visual quality and ocular comfort, characterized by the damage of the marginal conjunctiva of the upper eyelid. This review critically examines the current strategies for LWE identification and explores the multifactorial etiology of LWE and its association with various ocular surface diseases. A literature review conducted on PubMed identified 67 relevant studies, which were analyzed to enhance understanding of LWE’s diagnostic criteria and its clinical implications, offering future perspectives on improving diagnostic accuracy and patient outcomes.

The association between LWE and contact lens-related discomfort is examined, with studies reporting conflicting findings regarding its prevalence and severity among soft contact lens wearers. Moreover, LWE has been linked to tear film abnormalities, altered tear composition, and eyelid margin abnormalities in non-contact lens wearers, further complicating diagnosis and management.

Current LWE grading systems, including subjective methods and semi-objective approaches, are reviewed, highlighting challenges such as subjectivity, complexity, and variability. Recent advances in LWE grading, including semi-automated methods and photographic scales, show promise but face implementation challenges in clinical settings.

The review concludes by proposing areas for further research, including investigating factors contributing to LWE onset and development, developing more sensitive diagnostic tools, and exploring the impact of LWE on ocular surface health and visual function. Standardization, validation, and innovation in grading systems are emphasized to enhance diagnostic accuracy and improve clinical outcomes for patients with LWE. Ongoing research in LWE grading is essential for addressing diagnostic challenges and optimizing assessment methodologies in clinical practice.

眼睑拭泪上皮病变（LWE）是一种公认的影响视觉质量和眼部舒适度的眼部疾病，其特点是上眼睑边缘结膜受损。这篇综述批判性地研究了目前识别 LWE 的策略，并探讨了 LWE 的多因素病因及其与各种眼表疾病的关联。在 PubMed 上进行的文献综述确定了 67 项相关研究，通过对这些研究的分析，加深了对 LWE 诊断标准及其临床意义的理解，为提高诊断准确性和患者预后提供了未来展望。研究还探讨了 LWE 与隐形眼镜相关不适之间的关联，研究报告中关于软性隐形眼镜配戴者的患病率和严重程度的结论相互矛盾。此外，LWE 还与非隐形眼镜佩戴者的泪膜异常、泪液成分改变和眼睑边缘异常有关，从而使诊断和管理更加复杂。本文对目前的 LWE 分级系统（包括主观方法和半客观方法）进行了综述，并强调了主观性、复杂性和可变性等挑战。LWE 分级方面的最新进展，包括半自动化方法和摄影量表，显示了其前景，但在临床环境中的实施面临挑战。综述最后提出了进一步研究的领域，包括调查导致 LWE 发病和发展的因素、开发更灵敏的诊断工具以及探索 LWE 对眼表健康和视觉功能的影响。文章强调了分级系统的标准化、验证和创新，以提高诊断准确性，改善 LWE 患者的临床疗效。持续的 LWE 分级研究对于解决诊断难题和优化临床实践中的评估方法至关重要。

{"title":"Lid wiper epitheliopathy: Topical review of current identification strategies and future perspectives","authors":"Anitha Arvind , Rakesh Nanjappa , Krishna Kumar Gupta , Rute J. Macedo-de-Araújo , Daddi Fadel","doi":"10.1016/j.clae.2024.102312","DOIUrl":"10.1016/j.clae.2024.102312","url":null,"abstract":"<div><div>Lid Wiper Epitheliopathy (LWE) is a recognized ocular condition affecting visual quality and ocular comfort, characterized by the damage of the marginal conjunctiva of the upper eyelid. This review critically examines the current strategies for LWE identification and explores the multifactorial etiology of LWE and its association with various ocular surface diseases. A literature review conducted on PubMed identified 67 relevant studies, which were analyzed to enhance understanding of LWE’s diagnostic criteria and its clinical implications, offering future perspectives on improving diagnostic accuracy and patient outcomes.</div><div>The association between LWE and contact lens-related discomfort is examined, with studies reporting conflicting findings regarding its prevalence and severity among soft contact lens wearers. Moreover, LWE has been linked to tear film abnormalities, altered tear composition, and eyelid margin abnormalities in non-contact lens wearers, further complicating diagnosis and management.</div><div>Current LWE grading systems, including subjective methods and semi-objective approaches, are reviewed, highlighting challenges such as subjectivity, complexity, and variability. Recent advances in LWE grading, including semi-automated methods and photographic scales, show promise but face implementation challenges in clinical settings.</div><div>The review concludes by proposing areas for further research, including investigating factors contributing to LWE onset and development, developing more sensitive diagnostic tools, and exploring the impact of LWE on ocular surface health and visual function. Standardization, validation, and innovation in grading systems are emphasized to enhance diagnostic accuracy and improve clinical outcomes for patients with LWE. Ongoing research in LWE grading is essential for addressing diagnostic challenges and optimizing assessment methodologies in clinical practice.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102312"},"PeriodicalIF":4.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination effect of levofloxacin and cefmenoxime against ocular isolates of Pseudomonas aeruginosa 左氧氟沙星和头孢甲肟联用对眼部铜绿假单胞菌分离株的疗效。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-09-20 DOI: 10.1016/j.clae.2024.102311

Motohiro Itoi , Mark D.P. Willcox

Purpose

This study aimed to investigate the effects of the combination of levofloxacin (LVFX) and cefmenoxime (CMX) on ocular isolates of Pseudomonas aeruginosa.

Methods

Twenty-three strains of P. aeruginosa isolated from microbial keratitis cases in Australia were utilized in this study. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of each antibiotic alone were determined and the combined susceptibility of antibiotics was assessed through fractional inhibitory concentration index (FICI). Additionally, tolerance of a ciprofloxacin tolerant P. aeruginosa isolate to each antibiotic alone and combination were analyzed.

Results

The median MIC and MBC values of CMX against P. aeruginosa were 16 µg/mL and 32 µg/mL, respectively. The median MIC and MBC values of LVFX were 0.5 µg/mL and 1 µg/mL, respectively, and all isolates were susceptible. In dual combination, the median of FICI of all strains was 0.63; seven strains showed synergistic effects (FICI≤0.5), and fifteen strains showed additive activities, while no strains exhibited antagonism. The isolate of P. aeruginosa that had previously exhibited tolerance to ciprofloxacin showed high tolerance to CMX alone and low tolerance to LVFX alone. This strain showed low tolerance to the combination of CMX and LVFX.

Conclusion

The combination of LVFX with CMX may have beneficial interactions which increase antibacterial activity against P. aeruginosa isolates and may be a feasible option for addressing the issue of bacteria resistant to each antibiotic.

目的：本研究旨在探讨左氧氟沙星（LVFX）和头孢甲肟（CMX）联合用药对眼部铜绿假单胞菌分离株的影响：本研究采用了从澳大利亚微生物角膜炎病例中分离出的 23 株铜绿假单胞菌。测定了每种抗生素单独使用时的最低抑菌浓度（MIC）和最低杀菌浓度（MBC），并通过分数抑菌浓度指数（FICI）评估了抗生素的综合敏感性。此外，还分析了耐环丙沙星的铜绿微囊桿菌分离株对每种抗生素单独使用和联合使用的耐受性：结果：CMX 对铜绿假单胞菌的中位 MIC 值和 MBC 值分别为 16 µg/mL 和 32 µg/mL。LVFX 的中位 MIC 值和 MBC 值分别为 0.5 µg/mL 和 1 µg/mL，所有分离菌株均对其敏感。在双重组合中，所有菌株的 FICI 中值为 0.63；7 种菌株表现出协同效应（FICI≤0.5），15 种菌株表现出相加活性，没有菌株表现出拮抗作用。之前对环丙沙星耐受的铜绿假单胞菌分离株对 CMX 单药耐受性较高，对 LVFX 单药耐受性较低。该菌株对 CMX 和 LVFX 的组合耐受性较低：结论：LVFX 与 CMX 的组合可能会产生有益的相互作用，从而提高对铜绿假单胞菌分离株的抗菌活性，这可能是解决细菌对每种抗生素产生耐药性问题的一个可行方案。

{"title":"Combination effect of levofloxacin and cefmenoxime against ocular isolates of Pseudomonas aeruginosa","authors":"Motohiro Itoi , Mark D.P. Willcox","doi":"10.1016/j.clae.2024.102311","DOIUrl":"10.1016/j.clae.2024.102311","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to investigate the effects of the combination of levofloxacin (LVFX) and cefmenoxime (CMX) on ocular isolates of <em>Pseudomonas aeruginosa.</em></div></div><div><h3>Methods</h3><div>Twenty-three strains of <em>P. aeruginosa</em> isolated from microbial keratitis cases in Australia were utilized in this study. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of each antibiotic alone were determined and the combined susceptibility of antibiotics was assessed through fractional inhibitory concentration index (FICI). Additionally, tolerance of a ciprofloxacin tolerant <em>P. aeruginosa</em> isolate to each antibiotic alone and combination were analyzed.</div></div><div><h3>Results</h3><div>The median MIC and MBC values of CMX against <em>P. aeruginosa</em> were 16 µg/mL and 32 µg/mL, respectively. The median MIC and MBC values of LVFX were 0.5 µg/mL and 1 µg/mL, respectively, and all isolates were susceptible. In dual combination, the median of FICI of all strains was 0.63; seven strains showed synergistic effects (FICI≤0.5), and fifteen strains showed additive activities, while no strains exhibited antagonism. The isolate of <em>P. aeruginosa</em> that had previously exhibited tolerance to ciprofloxacin showed high tolerance to CMX alone and low tolerance to LVFX alone. This strain showed low tolerance to the combination of CMX and LVFX.</div></div><div><h3>Conclusion</h3><div>The combination of LVFX with CMX may have beneficial interactions which increase antibacterial activity against <em>P. aeruginosa</em> isolates and may be a feasible option for addressing the issue of bacteria resistant to each antibiotic.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102311"},"PeriodicalIF":4.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Turkish version of the 5-item Dry Eye Questionnaire (T-DEQ-5): Translation, validity, and reliability 土耳其版 5 项干眼症问卷（T-DEQ-5）：翻译、有效性和可靠性。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-09-17 DOI: 10.1016/j.clae.2024.102309

Semra Akkaya Turhan , Elif Bagatur Vurgun , Ece Yalçındağ , Samet Gülkaş , Canan Şanal Toprak , Ayşe Ebru Toker

Purpose

To evaluate the reliability and validity of Turkish translation of the 5-item Dry Eye Questionnaire (T-DEQ-5) and to compare it with the Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), corneal staining, and Schirmer test results.

Methods

The linguistic validation procedures adopted internationally, including forward translations, backward translation into English, examination of the translation quality, and a pilot test on 10 subjects, were employed. The translated and validated questionnaire was applied to 25 subjects two-time points (second time within three days) to evaluate the intra-test reliability. One hundred subjects were recruited for the study. They underwent an ophthalmic examination, including Schirmer tests, TBUT, and ocular surface staining (OSS) after completing OSDI questionnaire. Receiver operating characteristics (ROC) were assessed to determine sensitivity and specificity of the T-DEQ-5.

Results

The mean age of subjects was 45.7 ± 16.2 years, with 65 % being female. Overall, the test–retest reliability was excellent with an intra-class correlation coefficient value of 0.95 (95 % CI 0.90–0.98, p < 0.001). The Cronbach’s alpha reliability coefficient was 0.90, which demonstrated a strong level of internal consistency of the T-DEQ-5. Using ROC analysis to compare the results of the T-DEQ-5 with those of the OSDI, the area under the curve was found 0.95, with an optimal cut-off threshold of 6, resulting in 81 % sensitivity and 91 % specificity. Establishing the diagnosis based on a positive OSDI (≥13) and at least one positive sign (TBUT and/or OSS) yielded a sensitivity of 95 % and a specificity of 87 % at the cut-off threshold of 6.

Conclusion

The Turkish version of the DEQ-5 is a valid and reliable questionnaire and capable of differentiating patients with dry eye.

目的评估土耳其语翻译的 5 项干眼症问卷（T-DEQ-5）的可靠性和有效性，并将其与眼表疾病指数（OSDI）问卷、泪液破裂时间（TBUT）、角膜染色和 Schirmer 测试结果进行比较。方法采用国际通用的语言验证程序，包括正译、反译成英语、检查翻译质量和对 10 名受试者进行试点测试。翻译和验证后的问卷对 25 名受试者进行了两次测试（第二次测试在三天内进行），以评估测试内信度。研究共招募了 100 名受试者。他们在填写 OSDI 问卷后接受了眼科检查，包括施尔默试验、TBUT 和眼表染色（OSS）。结果受试者的平均年龄为（45.7 ± 16.2）岁，其中 65% 为女性。总体而言，测试-重复测试的可靠性极佳，类内相关系数为 0.95 (95 % CI 0.90-0.98, p < 0.001)。Cronbach's阿尔法信度系数为0.90，表明T-DEQ-5具有很强的内部一致性。通过 ROC 分析比较 T-DEQ-5 和 OSDI 的结果，发现曲线下面积为 0.95，最佳临界值为 6，灵敏度为 81%，特异度为 91%。根据 OSDI 阳性（≥13）和至少一个阳性体征（TBUT 和/或 OSS）进行诊断，在 6 的临界值下，灵敏度为 95%，特异度为 87%。

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引用次数: 0

Comparison of upper eyelid pressure and ocular surface parameters in dry eye disease and benign essential Blepharospasm: A cross-sectional study 干眼症和良性本质性眼睑痉挛患者上眼睑压力和眼表参数的比较：一项横断面研究。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-09-14 DOI: 10.1016/j.clae.2024.102298

Guohong Zhao , Jingyi Wang , Qian Ma , Yiran Hao , Lei Tian , Ying Jie

Purpose

To compare the upper eyelid pressure (UEP) and ocular surface parameters between dry eye disease (DED) and DED coexisting with benign essential blepharospasm (BEB), exploring which parameters could assist in distinguishing between DED and BEB, as potential risk factors for DED with BEB.

Methods

All enrolled participants diagnosed with DED or DED coexisting with BEB were initially subjected to ocular surface disease index (OSDI) determination. Subsequently, the upper eyelid pressure was recorded using an innovative eyelid pressure measurement device, followed by a series of ocular surface examinations. The two groups were compared using the independent t-test and Mann-Whitney U test. A logistic regression analysis was performed to identify which parameters can predict the onset of blepharospasm.

Results

The BEB group achieved a higher upper eyelid pressure (101.9 ± 23.5mN vs 88.4 ± 18.1mN, P = 0.009), lower number of total blink (6.2 ± 4.2 vs 7.1 ± 4.1, P = 0.016), higher corneal fluorescein staining score (4.0 ± 1.9 vs 3.0 ± 1.7, P = 0.046), higher partial blink rate (0.9 ± 0.2 vs 0.5 ± 0.4, P = 0.000) and the lower grade of meibum expressibility (1 (1, 2) vs 2 (1, 3), P = 0.000) and meibum quality (1 (1, 1) vs 1 (1, 1), P = 0.033) compared with the DED group. The upper eyelid pressure (OR = 1.123), partial blink rate (OR = 0.014) and the grade of meibum expressibility (OR = 10.804) showed significant associations with BEB (P < 0.05).

Conclusion

Despite similar OSDI scores, DED coexisting with BEB exhibited higher upper eyelid pressure, lower corneal fluorescein staining score, lower partial blink rate, more total blinks, lower grades of meibum expressibility, and lower meibum quality compared to DED alone. Among these, higher upper eyelid pressure, lower partial blink rate, and worse grade of meibum expressibility were identified as risk factors for BEB in DED.

目的：比较干眼症（DED）和伴有良性眼睑痉挛（BEB）的DED之间的上眼睑压（UEP）和眼表参数，探讨哪些参数可以帮助区分DED和BEB，并作为伴有BEB的DED的潜在风险因素：方法：所有被诊断为 DED 或 DED 并发 BEB 的参试者首先接受眼表疾病指数（OSDI）测定。随后，使用创新的眼睑压力测量装置记录上眼睑压力，并进行一系列眼表检查。采用独立 t 检验和 Mann-Whitney U 检验对两组患者进行比较。为了确定哪些参数可以预测眼睑痉挛的发生，还进行了逻辑回归分析：结果：BEB 组的上眼睑压力更高（101.9 ± 23.5mN vs 88.4 ± 18.1mN，P = 0.009），总眨眼次数更少（6.2 ± 4.2 vs 7.1 ± 4.1，P = 0.016），角膜荧光素染色评分更高（4.0 ± 1.9 vs 3.0 ± 1.7，P = 0.046），部分眨眼率较高（0.9 ± 0.2 vs 0.5 ± 0.4，P = 0.000），以及与 DED 组相比，睑板腺分泌率（1（1，2） vs 2（1，3），P = 0.000）和睑板腺质量（1（1，1） vs 1（1，1），P = 0.033）等级较低。上眼睑压力（OR = 1.123）、部分眨眼率（OR = 0.014）和睑板腺分泌物等级（OR = 10.804）与 BEB 有显著相关性（P 结论：尽管 OSDI 评分与 DED 组相似，但 DED 组的上眼睑压力、部分眨眼率和睑板腺分泌物等级与 BEB 有显著相关性：尽管OSDI评分相似，但与单纯DED相比，DED合并BEB表现出更高的上眼睑压力、更低的角膜荧光素染色评分、更低的部分眨眼率、更多的总眨眼次数、更低的睑板腺分泌度等级以及更低的睑板腺质量。其中，较高的上眼睑压力、较低的部分眨眼率和较差的睑板腺分泌物质量被确定为 DED 中 BEB 的风险因素。

{"title":"Comparison of upper eyelid pressure and ocular surface parameters in dry eye disease and benign essential Blepharospasm: A cross-sectional study","authors":"Guohong Zhao , Jingyi Wang , Qian Ma , Yiran Hao , Lei Tian , Ying Jie","doi":"10.1016/j.clae.2024.102298","DOIUrl":"10.1016/j.clae.2024.102298","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the upper eyelid pressure (UEP) and ocular surface parameters between dry eye disease (DED) and DED coexisting with benign essential blepharospasm (BEB), exploring which parameters could assist in distinguishing between DED and BEB, as potential risk factors for DED with BEB.</div></div><div><h3>Methods</h3><div>All enrolled participants diagnosed with DED or DED coexisting with BEB were initially subjected to ocular surface disease index (OSDI) determination. Subsequently, the upper eyelid pressure was recorded using an innovative eyelid pressure measurement device, followed by a series of ocular surface examinations. The two groups were compared using the independent <em>t</em>-test and Mann-Whitney <em>U</em> test. A logistic regression analysis was performed to identify which parameters can predict the onset of blepharospasm.</div></div><div><h3>Results</h3><div>The BEB group achieved a higher upper eyelid pressure (101.9 ± 23.5mN vs 88.4 ± 18.1mN, P = 0.009), lower number of total blink (6.2 ± 4.2 vs 7.1 ± 4.1, P = 0.016), higher corneal fluorescein staining score (4.0 ± 1.9 vs 3.0 ± 1.7, P = 0.046), higher partial blink rate (0.9 ± 0.2 vs 0.5 ± 0.4, P = 0.000) and the lower grade of meibum expressibility (1 (1, 2) vs 2 (1, 3), P = 0.000) and meibum quality (1 (1, 1) vs 1 (1, 1), P = 0.033) compared with the DED group. The upper eyelid pressure (OR = 1.123), partial blink rate (OR = 0.014) and the grade of meibum expressibility (OR = 10.804) showed significant associations with BEB (P < 0.05).</div></div><div><h3>Conclusion</h3><div>Despite similar OSDI scores, DED coexisting with BEB exhibited higher upper eyelid pressure, lower corneal fluorescein staining score, lower partial blink rate, more total blinks, lower grades of meibum expressibility, and lower meibum quality compared to DED alone. Among these, higher upper eyelid pressure, lower partial blink rate, and worse grade of meibum expressibility were identified as risk factors for BEB in DED.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102298"},"PeriodicalIF":4.1,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

International trends in prescribing silicone hydrogel contact lenses for daily wear (2000–2023): An update 日戴硅水凝胶隐形眼镜处方的国际趋势（2000-2023 年）：更新。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-09-14 DOI: 10.1016/j.clae.2024.102310

Nathan Efron , Philip B. Morgan , Craig A. Woods , Deborah Jones , Lyndon Jones , Jason J. Nichols

Purpose

Introduced around the turn of the 21st century, silicone hydrogel contact lenses alleviated hypoxic anterior eye complications due to their high oxygen transmissibility. The purpose of this work is to update earlier surveys by describing international trends in silicone hydrogel daily wear contact lens fitting between 2000 and 2023.

Method

An annual contact lens prescribing survey was sent to eye care practitioners in up to 71 countries between 2000 and 2023. Data relating to 260,144 daily wear soft contact lens fits undertaken in 20 countries returning reliable longitudinal data were analysed in respect of silicone hydrogel daily wear contact lens fitting.

Results

There has been a dramatic increase in silicone hydrogel daily wear lens fits (p < 0.0001), increasing from 2.8 % of all daily wear soft lens fits in 2000 to 73.7 % in 2023. Of all daily wear soft contact lenses prescribed to males, 44.6 % were silicone hydrogel lenses, compared with 43.5 % for females (p = 0.0146). The mean age of those wearing silicone hydrogel daily wear lenses was 32.0 ± 14.5 years, compared to 30.4 ± 13.6 years for those wearing daily wear hydrogel lenses (p < 0.0001). Between 2019–2023, the average percentage of fits was – (a) material type: silicone hydrogel – 73 %; mid-water content hydrogels – 13 %; high water content hydrogels – 9 %; and low water content hydrogels – 5 %, and (b) lens design: spherical – 44 %, toric – 32 %, multifocal – 17 %, monovision – 4 %, and ‘other’ – 3 %.

Conclusion

The dramatic increase in silicone hydrogel contact lens prescribing for daily wear has been commensurate with the introduction of multiple lens brands and an ongoing expansion of lens designs, parameters and replacement frequency options. The balance between silicone hydrogel and hydrogel lens prescribing is perhaps starting to approach an equilibrium.

目的：硅水凝胶隐形眼镜在 21 世纪初问世，因其氧气透过率高而缓解了缺氧性前眼并发症。这项工作的目的是通过描述 2000 年至 2023 年硅水凝胶日抛型隐形眼镜验配的国际趋势来更新之前的调查：方法：在 2000 年至 2023 年期间，每年向多达 71 个国家的眼科护理从业人员发送隐形眼镜处方调查。对 20 个国家的 260,144 例日间配戴软性隐形眼镜的数据进行了分析，并返回了有关硅水凝胶日间配戴隐形眼镜的可靠纵向数据：结果：硅水凝胶日抛型隐形眼镜的配戴量急剧增加（p 结论：硅水凝胶日抛型隐形眼镜的配戴量急剧增加（p）：硅水凝胶日抛隐形眼镜处方量的急剧增加与多种镜片品牌的引入以及镜片设计、参数和更换频率选择的不断扩大是相适应的。硅水凝胶和水凝胶镜片处方之间的平衡也许正开始接近平衡。

{"title":"International trends in prescribing silicone hydrogel contact lenses for daily wear (2000–2023): An update","authors":"Nathan Efron , Philip B. Morgan , Craig A. Woods , Deborah Jones , Lyndon Jones , Jason J. Nichols","doi":"10.1016/j.clae.2024.102310","DOIUrl":"10.1016/j.clae.2024.102310","url":null,"abstract":"<div><h3>Purpose</h3><div>Introduced around the turn of the 21st century, silicone hydrogel contact lenses alleviated hypoxic anterior eye complications due to their high oxygen transmissibility. The purpose of this work is to update earlier surveys by describing international trends in silicone hydrogel daily wear contact lens fitting between 2000 and 2023.</div></div><div><h3>Method</h3><div>An annual contact lens prescribing survey was sent to eye care practitioners in up to 71 countries between 2000 and 2023. Data relating to 260,144 daily wear soft contact lens fits undertaken in 20 countries returning reliable longitudinal data were analysed in respect of silicone hydrogel daily wear contact lens fitting.</div></div><div><h3>Results</h3><div>There has been a dramatic increase in silicone hydrogel daily wear lens fits (p < 0.0001), increasing from 2.8 % of all daily wear soft lens fits in 2000 to 73.7 % in 2023. Of all daily wear soft contact lenses prescribed to males, 44.6 % were silicone hydrogel lenses, compared with 43.5 % for females (p = 0.0146). The mean age of those wearing silicone hydrogel daily wear lenses was 32.0 ± 14.5 years, compared to 30.4 ± 13.6 years for those wearing daily wear hydrogel lenses (p < 0.0001). Between 2019–2023, the average percentage of fits was – (a) material type: silicone hydrogel – 73 %; mid-water content hydrogels – 13 %; high water content hydrogels – 9 %; and low water content hydrogels – 5 %, and (b) lens design: spherical – 44 %, toric – 32 %, multifocal – 17 %, monovision – 4 %, and ‘other’ – 3 %.</div></div><div><h3>Conclusion</h3><div>The dramatic increase in silicone hydrogel contact lens prescribing for daily wear has been commensurate with the introduction of multiple lens brands and an ongoing expansion of lens designs, parameters and replacement frequency options. The balance between silicone hydrogel and hydrogel lens prescribing is perhaps starting to approach an equilibrium.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"47 6","pages":"Article 102310"},"PeriodicalIF":4.1,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective impressions with myopia control contact lenses versus single vision lenses: A systematic review and meta-analysis. 近视控制隐形眼镜与单光镜片的主观感受：系统回顾和荟萃分析。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-09-13 DOI: 10.1016/j.clae.2024.102303

Xiaona Ping, Nayuta Yoshioka, Juno Kim, Padmaja Sankaridurg

Purpose: To gain insight into patients' visual experiences and satisfaction when using different forms of myopia control lenses.

Methods: PubMed, Cochrane Library, Embase, Scopus and Web of Science databases were searched for articles assessing subjective visual quality with myopia control lenses compared with single-vision lenses (SVLs) up to July 10, 2023. Eight-hundred-and-three articles were retrieved, reviewed and any questionnaire items on subjective impressions of lens wear were meta-analysed. Subgroup analyses were based on the magnitude of defocus (add power) of multifocal soft contact lenses (MFSCLs) and age groups. A random-effects model was employed for meta-analysis, and I² statistic used to assess the statistical heterogeneity.

Results: Nineteen articles fit the criteria, but only six articles involving MFSCLs had relevant data. MFSCLs were associated with lower subjective ratings of vision at different distances compared to SVLs (p < 0.001), but the differences were less than one unit. MFSCLs also yielded lower ratings when moving or walking and/or climbing stairs at -0.38 (-0.69 to -0.07, p = 0.02; I² = 85 %, p < 0.001) and for subjective comfort (difference of -0.23, -0.41 to -0.05, p = 0.01; I² = 63 %, p < 0.001). Subjective ratings for playing sports were not different between groups. Experience with MFSCLs was rated lower by young adults compared to children for all variables. In both children and young adults, ratings were lower with higher add compared to lower add MFSCLs.

Conclusion: Although subjective ratings for vision and comfort were lower with MFSCLs compared to SVLs, the difference was mostly less than one unit. Importantly, young adults rated their visual experience lower compared to children.

目的：了解患者在使用不同形式的近视控制镜片时的视觉体验和满意度：在 PubMed、Cochrane Library、Embase、Scopus 和 Web of Science 数据库中搜索了截至 2023 年 7 月 10 日有关近视控制镜片与单视镜 (SVL) 相比的主观视觉质量评估文章。共检索到八百零三篇文章，对其进行了审查，并对所有关于镜片佩戴主观印象的问卷项目进行了荟萃分析。根据多焦点软性隐形眼镜（MFSCLs）的散焦程度（附加功率）和年龄组进行了分组分析。采用随机效应模型进行荟萃分析，并使用 I2 统计量评估统计异质性：结果：19 篇文章符合标准，但只有 6 篇涉及超薄型角膜塑形镜的文章有相关数据。与 SVL 相比，MFSCL 在不同距离上的视力主观评分较低（P 2 = 85 %，P 2 = 63 %，P 结论：虽然视力和视力主观评分与 SVL 的主观评分存在差异，但 MFSCL 在不同距离上的视力主观评分较低：虽然与 SVL 相比，MFSCL 在视力和舒适度方面的主观评分较低，但差异大多小于一个单位。重要的是，年轻人对视觉体验的评分低于儿童。

{"title":"Subjective impressions with myopia control contact lenses versus single vision lenses: A systematic review and meta-analysis.","authors":"Xiaona Ping, Nayuta Yoshioka, Juno Kim, Padmaja Sankaridurg","doi":"10.1016/j.clae.2024.102303","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102303","url":null,"abstract":"<p><strong>Purpose: </strong>To gain insight into patients' visual experiences and satisfaction when using different forms of myopia control lenses.</p><p><strong>Methods: </strong>PubMed, Cochrane Library, Embase, Scopus and Web of Science databases were searched for articles assessing subjective visual quality with myopia control lenses compared with single-vision lenses (SVLs) up to July 10, 2023. Eight-hundred-and-three articles were retrieved, reviewed and any questionnaire items on subjective impressions of lens wear were meta-analysed. Subgroup analyses were based on the magnitude of defocus (add power) of multifocal soft contact lenses (MFSCLs) and age groups. A random-effects model was employed for meta-analysis, and I<sup>2</sup> statistic used to assess the statistical heterogeneity.</p><p><strong>Results: </strong>Nineteen articles fit the criteria, but only six articles involving MFSCLs had relevant data. MFSCLs were associated with lower subjective ratings of vision at different distances compared to SVLs (p < 0.001), but the differences were less than one unit. MFSCLs also yielded lower ratings when moving or walking and/or climbing stairs at -0.38 (-0.69 to -0.07, p = 0.02; I<sup>2</sup> = 85 %, p < 0.001) and for subjective comfort (difference of -0.23, -0.41 to -0.05, p = 0.01; I<sup>2</sup> = 63 %, p < 0.001). Subjective ratings for playing sports were not different between groups. Experience with MFSCLs was rated lower by young adults compared to children for all variables. In both children and young adults, ratings were lower with higher add compared to lower add MFSCLs.</p><p><strong>Conclusion: </strong>Although subjective ratings for vision and comfort were lower with MFSCLs compared to SVLs, the difference was mostly less than one unit. Importantly, young adults rated their visual experience lower compared to children.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102303"},"PeriodicalIF":4.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “The effects of eyelash extensions on the ocular surface” [Cont. Lens Anterior Eye. 47(2) (2024) 102109] 睫毛嫁接对眼表的影响"[Cont. Lens Anterior Eye.

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2024-09-10 DOI: 10.1016/j.clae.2024.102286

Jiaxin Han , Zihong Xie , Xingwei Zhu , Wanting Ruan , Meng Lin , Zhiqiang Xu , Lijie Miao , Junyang Zhong , Fan Lu , Liang Hu

引用次数: 0