Contact Lens & Anterior Eye最新文献_第2页

The effect of extended periods of mini-scleral lens wear on the conjunctival/episcleral and scleral thickness 长时间佩戴微型巩膜透镜对结膜/巩膜外膜和巩膜厚度的影响。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102289

Ruveyde Bolac, Merve Beyza Yıldız, Oksan Alpogan, Yasemin Un, Mehmet Serhat Mangan

Purpose

To evaluate the conjunctival/episcleral thickness (CET) and anterior scleral thickness (AST) in patients with keratoconus with an extended duration of mini-scleral contact lens wear by utilizing anterior segment optical coherence tomography (ASOCT).

Methods

This study included 17 eyes of 17 patients with keratoconus with mini-scleral contact lens wear (Group 1), 20 eyes of 20 patients with keratoconus without any contact lens wear (Group 2), and 20 eyes of 20 healthy controls (Group 3). CET and AST were measured using AS-OCT (Triton, Topcon, Japan) at 1, 2, and 3 mm posterior to the scleral spur in the nasal, temporal, superior, and inferior quadrants.

Results

The median age of the mini-scleral contact lens group was 26, and the number of male patients was 14 (82.4 %). The superior CET values at 1 mm, 2 mm, and 3 mm statistically differed between the groups, with Group 1 having significantly lower values than Group 3 and Group 2 having statistically similar values to the remaining two groups. The inferior CET at 2 mm was lower in Groups 1 and 2 than in Group 3. The inferior CET at 3 mm was lower in Group 1 compared to Groups 2 and 3.

AST was similar between the groups at all measured quadrants and distances. The duration of lens wear had a strong, statistically significant, negative correlation with the superior CET at 2 mm (rho: −0.847, p < 0.001) and a moderate, statistically significant, negative correlation with the superior CET at 3 mm (rho: −0.506, p < 0.038).

Conclusions

In this study, it was found that mini-scleral contact lens usage causes thinning in the conjunctival-episcleral layer, especially in the superior and inferior quadrants, but does not affect scleral thickness. AS-OCT is a non-invasive and clinically applicable technique for assessing the impact of contact lens use on the conjunctiva/episclera and sclera.

目的：利用前节光学相干断层扫描（ASOCT）评估长期佩戴微型巩膜接触镜的角膜病患者的结膜/巩膜外膜厚度（CET）和前巩膜厚度（AST）：本研究包括 17 名佩戴微型巩膜接触镜的角膜病患者的 17 只眼睛（第 1 组）、20 名未佩戴任何接触镜的角膜病患者的 20 只眼睛（第 2 组）和 20 名健康对照者的 20 只眼睛（第 3 组）。使用 AS-OCT（Triton，日本拓普康公司）在鼻、颞、上和下象限巩膜骨刺后 1、2 和 3 毫米处测量 CET 和 AST：迷你巩膜接触镜组的中位年龄为 26 岁，男性患者为 14 人（82.4%）。各组在 1 毫米、2 毫米和 3 毫米处的上部 CET 值在统计学上存在差异，第一组的值明显低于第三组，而第二组的值在统计学上与其余两组相似。第 1 组和第 2 组 2 毫米处的下部 CET 低于第 3 组，第 1 组 3 毫米处的下部 CET 低于第 2 组和第 3 组。在所有测量的象限和距离上，各组之间的 AST 相似。镜片配戴时间与 2 毫米处的上部 CET 呈显著负相关（rho：-0.847，p 结论：本研究发现，佩戴微型巩膜接触镜会导致结膜-巩膜外层变薄，尤其是在上象限和下象限，但不会影响巩膜厚度。AS-OCT 是一种非侵入性且适用于临床的技术，可用于评估使用隐形眼镜对结膜/巩膜和巩膜的影响。

{"title":"The effect of extended periods of mini-scleral lens wear on the conjunctival/episcleral and scleral thickness","authors":"Ruveyde Bolac, Merve Beyza Yıldız, Oksan Alpogan, Yasemin Un, Mehmet Serhat Mangan","doi":"10.1016/j.clae.2024.102289","DOIUrl":"10.1016/j.clae.2024.102289","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the conjunctival/episcleral thickness (CET) and anterior scleral thickness (AST) in patients with keratoconus with an extended duration of mini-scleral contact lens wear by utilizing anterior segment optical coherence tomography (ASOCT).</div></div><div><h3>Methods</h3><div>This study included 17 eyes of 17 patients with keratoconus with mini-scleral contact lens wear (Group 1), 20 eyes of 20 patients with keratoconus without any contact lens wear (Group 2), and 20 eyes of 20 healthy controls (Group 3). CET and AST were measured using AS-OCT (Triton, Topcon, Japan) at 1, 2, and 3 mm posterior to the scleral spur in the nasal, temporal, superior, and inferior quadrants.</div></div><div><h3>Results</h3><div>The median age of the mini-scleral contact lens group was 26, and the number of male patients was 14 (82.4 %). The superior CET values at 1 mm, 2 mm, and 3 mm statistically differed between the groups, with Group 1 having significantly lower values than Group 3 and Group 2 having statistically similar values to the remaining two groups. The inferior CET at 2 mm was lower in Groups 1 and 2 than in Group 3. The inferior CET at 3 mm was lower in Group 1 compared to Groups 2 and 3.</div><div>AST was similar between the groups at all measured quadrants and distances. The duration of lens wear had a strong, statistically significant, negative correlation with the superior CET at 2 mm (rho: −0.847, p < 0.001) and a moderate, statistically significant, negative correlation with the superior CET at 3 mm (rho: −0.506, p < 0.038).</div></div><div><h3>Conclusions</h3><div>In this study, it was found that mini-scleral contact lens usage causes thinning in the conjunctival-episcleral layer, especially in the superior and inferior quadrants, but does not affect scleral thickness. AS-OCT is a non-invasive and clinically applicable technique for assessing the impact of contact lens use on the conjunctiva/episclera and sclera.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102289"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in anterior segment after short-term scleral lens wear in healthy Chinese population 中国健康人群短期佩戴巩膜透镜后眼前节的变化。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102291

Qianni Jiang , Zhe Zhang , Lingling Niu , Bingjie Wang , Daddi Fadel , Ruihua Wei , Zhi Chen

Purpose

To evaluate the impact of short-term scleral lens (SL) wear on anterior chamber (AC) dimension and central corneal thickness (CCT) in healthy Chinese people.

Methods

This is a prospective, daily wear study. Eligible participants were dispensed SLs to correct refractive errors. Anterior segment (AS) parameters were measured by AS optical coherence tomography (AS-OCT) before, during, and after 2 and 4 hours of lens wear. Repeated-measures analysis of variance (ANOVA) was used to analyze the changes in AS parameters over time.

Results

Twelve subjects (10 females and 2 males) with a mean age of 25.3 ± 3.8 years (ranging from 21 to 34 years) were recruited. The AC parameters, including anterior chamber depth (ACD) from the endothelium (endo-ACD), angle opening distance at 500 μm (AOD500), and trabecular-iris space area at 500 μm (TISA500), significantly decreased after wearing SLs for 4 hours (P<0.05). CCT increased by 12 μm (2.29 %) after wearing SLs for 4 hours (P=0.013).

Conclusion

This study suggests that SL wear has a significant impact on AS dimensions in patients with healthy corneas in the short term with SL in situ, but tend to recover quickly after SL removal. Further research is needed to determine whether the change in AS dimensions during SL wear affects aqueous humor (AH) outflow and causes changes in intraocular pressure (IOP).

目的：评估健康中国人短期佩戴巩膜透镜（SL）对前房（AC）尺寸和中央角膜厚度（CCT）的影响：这是一项前瞻性日常配戴研究。方法：这是一项前瞻性的每日配戴研究，符合条件的参与者配戴睫状体镜片来矫正屈光不正。在戴镜前、戴镜期间以及戴镜 2 小时和 4 小时后，通过 AS 光学相干断层扫描（AS-OCT）测量前段（AS）参数。采用重复测量方差分析（ANOVA）分析AS参数随时间的变化：共招募了 12 名受试者（10 名女性和 2 名男性），平均年龄为 25.3 ± 3.8 岁（21 至 34 岁不等）。结果：12 名受试者（10 名女性和 2 名男性，平均年龄为 25.3 ± 3.8 岁，从 21 岁到 34 岁不等）在佩戴 SL 4 小时后，AC 参数，包括前房距内皮深度（ACD）（endo-ACD）、500 μm 时的开角距离（AOD500）和 500 μm 时的小梁-虹膜间隙面积（TISA500）显著下降（PConclusion：这项研究表明，在原位佩戴角膜塑形镜的情况下，短期内佩戴角膜塑形镜会对健康角膜患者的AS尺寸产生重大影响，但在摘除角膜塑形镜后会迅速恢复。还需要进一步研究，以确定在佩戴角膜塑形镜期间，角膜塑形镜尺寸的变化是否会影响房水（AH）的流出并导致眼压（IOP）的变化。

{"title":"Changes in anterior segment after short-term scleral lens wear in healthy Chinese population","authors":"Qianni Jiang , Zhe Zhang , Lingling Niu , Bingjie Wang , Daddi Fadel , Ruihua Wei , Zhi Chen","doi":"10.1016/j.clae.2024.102291","DOIUrl":"10.1016/j.clae.2024.102291","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the impact of short-term scleral lens (SL) wear on anterior chamber (AC) dimension and central corneal thickness (CCT) in healthy Chinese people.</div></div><div><h3>Methods</h3><div>This is a prospective, daily wear study. Eligible participants were dispensed SLs to correct refractive errors. Anterior segment (AS) parameters were measured by AS optical coherence tomography (AS-OCT) before, during, and after 2 and 4 hours of lens wear. Repeated-measures analysis of variance (ANOVA) was used to analyze the changes in AS parameters over time.</div></div><div><h3>Results</h3><div>Twelve subjects (10 females and 2 males) with a mean age of 25.3 ± 3.8 years (ranging from 21 to 34 years) were recruited. The AC parameters, including anterior chamber depth (ACD) from the endothelium (<em>endo</em>-ACD), angle opening distance at 500 μm (AOD500), and trabecular-iris space area at 500 μm (TISA500), significantly decreased after wearing SLs for 4 hours (P<0.05). CCT increased by 12 μm (2.29 %) after wearing SLs for 4 hours (P=0.013).</div></div><div><h3>Conclusion</h3><div>This study suggests that SL wear has a significant impact on AS dimensions in patients with healthy corneas in the short term with SL in situ, but tend to recover quickly after SL removal. Further research is needed to determine whether the change in AS dimensions during SL wear affects aqueous humor (AH) outflow and causes changes in intraocular pressure (IOP).</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102291"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of back optic zone diameter on corneal morphology with orthokeratology lenses 使用角膜塑形镜时，后视区直径对角膜形态的影响。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102178

Hao Li , Li Zeng , Can Chen , Jiaqi Zhou

Objective

This study aimed to compare the changes in corneal morphological characteristics in corneal topography assessments performed after wearing orthokeratology (OK) lenses with different back optic zone diameters (BOZDs). These changes included the change ratios of the apical corneal power (ACP), the maximum relative corneal refractive power (mRCRP), and the treatment zone diameter (TZD).

Methods

Data from 133 children with myopia (average age 9.50 ± 1.23 years) treated at Fudan University Eye and Ear, Nose, and Throat Hospital were retrospectively analyzed. All participants wore the same brand of tangent-design OK lens (corneal refractive therapy, CRT). According to the BOZD, the patients were divided into two groups, of 5.0 and 6.0 mm BOZD, respectively. Corneal topography was analyzed at baseline, as well as 1 day, 1 week, and 1 month after wearing the lenses, and the change ratios of ACP, mRCRP, and TZD were compared between the two groups.

Results

The change ratio of the ACP did not differ significantly between the BOZD 5.0 and 6.0 groups after 1 day or 1 week of lens wear (P = 0.170 and P = 0.113, respectively). However, after 1 month of lens wear, the change ratio of the ACP in the BOZD 5.0 group was significantly larger than that in the BOZD 6.0 group (P < 0.001). After 1 month of lens wear, the mRCRP along the horizontal and vertical meridians was higher (P < 0.05) and the TZD was significantly smaller (P < 0.001) in the BOZD 5.0 group than in the BOZD 6.0 group.

Conclusion

In CRT OK lenses, a small BOZD lens can produce faster corneal shaping, a larger mRCRP, and a smaller TZD, which may have a better effect on slowing ocular axial length elongation. The lens parameters are also a factor affecting the TZD.

研究目的本研究旨在比较佩戴不同后视区直径（BOZD）的角膜塑形镜（OK）后，角膜地形图评估中角膜形态特征的变化。这些变化包括角膜顶端力（ACP）、最大相对角膜屈光力（mRCRP）和治疗区直径（TZD）的变化比率：对复旦大学附属眼耳鼻喉科医院收治的133名近视儿童（平均年龄9.50 ± 1.23岁）的数据进行回顾性分析。所有参与者都配戴了同一品牌的切线设计OK镜（角膜屈光治疗，CRT）。根据角膜屈光度数（BOZD），患者被分为两组，分别为 5.0 毫米和 6.0 毫米。对基线、戴镜后1天、1周和1个月的角膜地形图进行分析，并比较两组患者的ACP、mRCRP和TZD的变化率：戴镜 1 天或 1 周后，ACP 的变化率在 BOZD 5.0 组和 6.0 组之间没有明显差异（分别为 P = 0.170 和 P = 0.113）。然而，戴镜 1 个月后，BOZD 5.0 组的 ACP 变化比明显大于 BOZD 6.0 组（P 结论：BOZD 5.0 组的 ACP 变化比明显大于 BOZD 6.0 组）：在 CRT OK 镜片中，小的 BOZD 镜片能产生更快的角膜塑形、更大的 mRCRP 和更小的 TZD，这可能对减缓眼轴长度伸长有更好的效果。镜片参数也是影响 TZD 的一个因素。

{"title":"Influence of back optic zone diameter on corneal morphology with orthokeratology lenses","authors":"Hao Li , Li Zeng , Can Chen , Jiaqi Zhou","doi":"10.1016/j.clae.2024.102178","DOIUrl":"10.1016/j.clae.2024.102178","url":null,"abstract":"<div><h3>Objective</h3><div><span>This study aimed to compare the changes in corneal morphological characteristics in </span>corneal topography assessments performed after wearing orthokeratology (OK) lenses with different back optic zone diameters (BOZDs). These changes included the change ratios of the apical corneal power (ACP), the maximum relative corneal refractive power (mRCRP), and the treatment zone diameter (TZD).</div></div><div><h3>Methods</h3><div>Data from 133 children with myopia (average age 9.50 ± 1.23 years) treated at Fudan University Eye and Ear, Nose, and Throat Hospital were retrospectively analyzed. All participants wore the same brand of tangent-design OK lens (corneal refractive therapy, CRT). According to the BOZD, the patients were divided into two groups, of 5.0 and 6.0 mm BOZD, respectively. Corneal topography was analyzed at baseline, as well as 1 day, 1 week, and 1 month after wearing the lenses, and the change ratios of ACP, mRCRP, and TZD were compared between the two groups.</div></div><div><h3>Results</h3><div>The change ratio of the ACP did not differ significantly between the BOZD 5.0 and 6.0 groups after 1 day or 1 week of lens wear (P = 0.170 and P = 0.113, respectively). However, after 1 month of lens wear, the change ratio of the ACP in the BOZD 5.0 group was significantly larger than that in the BOZD 6.0 group (P < 0.001). After 1 month of lens wear, the mRCRP along the horizontal and vertical meridians was higher (P < 0.05) and the TZD was significantly smaller (P < 0.001) in the BOZD 5.0 group than in the BOZD 6.0 group.</div></div><div><h3>Conclusion</h3><div>In CRT OK lenses, a small BOZD lens can produce faster corneal shaping, a larger mRCRP, and a smaller TZD, which may have a better effect on slowing ocular axial length elongation. The lens parameters are also a factor affecting the TZD.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102178"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specialise for special eyes in 2025 2025年专门为特殊的眼睛设计。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102356

Stephen J. Vincent, Pauline Cho

引用次数: 0

Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment 正视镜治疗 1 年期间儿童脉络膜血管的动态变化及其与近视控制效果的关系。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102314

Mengqi Liu , Jing Huang , Zhu Xie , Yuanyuan Wang , Pengqi Wang , Ruijing Xia , Xinting Liu , Binbin Su , Jia Qu , Xiangtian Zhou , Xinjie Mao , Hao Wu

Purpose

To investigate the dynamic changes of choroidal vasculature and its association in mediating ocular elongation over 1 year of orthokeratology (ortho-k) treatment.

Methods

This observational study included 8–14 year old myopic children who were willing to receive ortho-k treatment or wear single vision spectacle lenses (SVL). Axial length (AL) and choroidal characteristics, including submacular luminal area (LA), stromal area (SA), total choroidal area (TCA), choroidal vascularity index (CVI), subfoveal choroidal thickness (SFCT) and choriocapillaris flow deficits (CcFD) from OCT/OCTA images, were evaluated at baseline, 3, 6 and 12 months.

Results

After 1 year, AL elongation was significantly less in 25 children treated with ortho-k than in 29 children wearing SVL (0.17 ± 0.14 v.s. 0.28 ± 0.16 mm, P<0.01). In the ortho-k group, LA, SA, TCA and SFCT were significantly increased by 0.033 ± 0.059 mm², 0.024 ± 0.035 mm², 0.058 ± 0.087 mm², 8.9 ± 17.4 μm, respectively, at 3 months (all P<0.05). These parameters returned to near baseline levels over the following 9 months. Meanwhile, CcFD decreased by 0.83 ± 1.09 % over 12 months, but CVI remained steady during this period. No significant changes in these choroidal parameters (except for CcFD, decreased by −0.56 ± 1.23 %) were observed in the SVL group over 12 months. Increases in SFCT, LA, SA and TCA over 12 months were significantly greater in the ortho-k group than in the SVL group. Mediation analyses showed that 44.8 % of effect on inhibiting AL elongation through ortho-k was mediated via TCA (in particular LA).

Conclusions

The decelerated ocular elongation during ortho-k treatment is accompanied by increases in content of choroidal vascular lumen and stromal component. Dynamic changes of choroidal vasculature provide a possible mechanism underlying myopia control efficacy via ortho-k.

目的：研究正角膜塑形镜（ortho-k）治疗一年来脉络膜血管的动态变化及其与眼球伸长的关联：这项观察性研究纳入了愿意接受角膜矫形治疗或配戴单光眼镜（SVL）的8-14岁近视儿童。在基线、3个月、6个月和12个月时，对轴向长度（AL）和脉络膜特征进行评估，包括脉络膜下腔面积（LA）、基质面积（SA）、脉络膜总面积（TCA）、脉络膜血管指数（CVI）、眼底脉络膜厚度（SFCT）和OCT/OCTA图像显示的脉络膜瓣血流缺损（CcFD）：结果：1年后，25名接受ortho-k治疗的儿童的AL伸长率明显低于29名接受SVL治疗的儿童（3个月时分别为0.17 ± 0.14 v.s. 0.28 ± 0.16 mm, P2, 0.024 ± 0.035 mm2, 0.058 ± 0.087 mm2, 8.9 ± 17.4 μm）：在正钾治疗期间，眼球伸长速度减慢，同时脉络膜血管腔和基质成分含量增加。脉络膜血管的动态变化提供了通过角膜矫形器有效控制近视的可能机制。

{"title":"Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment","authors":"Mengqi Liu , Jing Huang , Zhu Xie , Yuanyuan Wang , Pengqi Wang , Ruijing Xia , Xinting Liu , Binbin Su , Jia Qu , Xiangtian Zhou , Xinjie Mao , Hao Wu","doi":"10.1016/j.clae.2024.102314","DOIUrl":"10.1016/j.clae.2024.102314","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the dynamic changes of choroidal vasculature and its association in mediating ocular elongation over 1 year of orthokeratology (<em>ortho</em>-k) treatment.</div></div><div><h3>Methods</h3><div>This observational study included 8–14 year old myopic children who were willing to receive <em>ortho</em>-k treatment or wear single vision spectacle lenses (SVL). Axial length (AL) and choroidal characteristics, including submacular luminal area (LA), stromal area (SA), total choroidal area (TCA), choroidal vascularity index (CVI), subfoveal choroidal thickness (SFCT) and choriocapillaris flow deficits (CcFD) from OCT/OCTA images, were evaluated at baseline, 3, 6 and 12 months.</div></div><div><h3>Results</h3><div>After 1 year, AL elongation was significantly less in 25 children treated with <em>ortho</em>-k than in 29 children wearing SVL (0.17 ± 0.14 v.s. 0.28 ± 0.16 mm, P<0.01). In the <em>ortho</em>-k group, LA, SA, TCA and SFCT were significantly increased by 0.033 ± 0.059 mm<sup>2</sup>, 0.024 ± 0.035 mm<sup>2</sup>, 0.058 ± 0.087 mm<sup>2</sup>, 8.9 ± 17.4 μm, respectively, at 3 months (all P<0.05). These parameters returned to near baseline levels over the following 9 months. Meanwhile, CcFD decreased by 0.83 ± 1.09 % over 12 months, but CVI remained steady during this period. No significant changes in these choroidal parameters (except for CcFD, decreased by −0.56 ± 1.23 %) were observed in the SVL group over 12 months. Increases in SFCT, LA, SA and TCA over 12 months were significantly greater in the <em>ortho</em>-k group than in the SVL group. Mediation analyses showed that 44.8 % of effect on inhibiting AL elongation through <em>ortho</em>-k was mediated via TCA (in particular LA).</div></div><div><h3>Conclusions</h3><div>The decelerated ocular elongation during <em>ortho</em>-k treatment is accompanied by increases in content of choroidal vascular lumen and stromal component. Dynamic changes of choroidal vasculature provide a possible mechanism underlying myopia control efficacy via <em>ortho</em>-k.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102314"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence versus conventional methods for RGP lens fitting in keratoconus 人工智能与传统角膜塑形镜验配方法的比较

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102321

Jérémy Abadou , Simon Dahan , Juliette Knoeri , Loic Leveziel , Nacim Bouheraoua , Vincent M Borderie

Background

To compare the efficiency of three artificial intelligence (AI) frameworks (Standard Machine Learning (ML), Multi-Layer Perceptron (MLP) and Convolution Neural Networks (CNN)) with a reference method (Mean radius of curvature (K)) to predict the posterior radius of curvature of the best-fitted rigid contact lens (RCBFL) in keratoconus eyes.

Methods

This retrospective study included 197 keratoconus eyes of 135 patients fitted with Rose K2® (Menicon®, Nagoya, Japan) rigid contact lenses with one or more topographies available (MS39®, CSO®, Ferrara, Italy) between January 2020 and September 2022. Two types of topographic data (indices and reconstructed maps from raw data) were used for AI analysis. Three distinct approaches were utilized for leveraging AI: Standard ML methods and MLPs based on topographic indices and CNNs based on topographic maps (i.e., corneal thickness, sagittal, and tangential maps). Seventeen AI framework’s accuracies were compared with the r² determination coefficient of linear regression between predicted and best-fitted radii. Framework accuracies were compared with the Fisher z-transformation of Pearson correlation coefficients.

Results

In multiple linear regression, only three topographic indices (i.e., 3- & 5-mm mean K and Kmax) were significantly associated with RCBFL (p ≤ 0.0001). Compared with the reference method (mean-K; r² = 0.36), a significantly better RCBFL prediction was achieved with Random Forest using the three topographic indices, MLP using all indices, ResNet18 CNN using anterior topographic maps and CNNs using combined parameters (0.69 ≤ r² ≤ 0.80; p < 0.05). The best accuracy was obtained with the EfficientNetB0 CNN trained with three maps (r² = 0.80).

Conclusions

Artificial intelligence methods, particularly CNNs, with corneal topography data of MS39® topographer, have demonstrated superiority over conventional approaches in predicting the posterior curvature radius of Rose K2® rigid contact lenses in patients with keratoconus.

背景：比较三种人工智能（AI）框架（标准机器学习（ML）、多层感知器（MLP）和卷积神经网络（CNN））与一种参考方法（平均曲率半径（K））预测角膜塑形镜最佳配戴硬性隐形眼镜（RCBFL）后曲率半径的效率：这项回顾性研究纳入了在 2020 年 1 月至 2022 年 9 月期间配戴了 Rose K2® （Menicon®，日本名古屋）硬性隐形眼镜的 135 名患者的 197 只角膜炎眼，这些患者配戴了一种或多种地形图（MS39®，CSO®，意大利费拉拉）。人工智能分析使用了两种地形图数据（指数和从原始数据重建的地图）。人工智能利用了三种不同的方法：基于地形指数的标准 ML 方法和 MLP，以及基于地形图（即角膜厚度图、矢状图和切线图）的 CNN。将 17 个人工智能框架的准确度与预测半径和最佳拟合半径之间线性回归的 r2 决定系数进行了比较。将框架的准确度与皮尔逊相关系数的费舍尔 z 变形进行了比较：在多元线性回归中，只有三个地形指数（即 3 和 5 mm 平均 K 值和 Kmax）与 RCBFL 显著相关（p ≤ 0.0001）。与参考方法（平均 K；r2 = 0.36）相比，使用三种地形指数的随机森林、使用所有指数的 MLP、使用前部地形图的 ResNet18 CNN 和使用组合参数的 CNNs 预测 RCBFL 的效果明显更好（0.69 ≤ r2 ≤ 0.80；p 2 = 0.80）：人工智能方法，尤其是使用 MS39® 角膜地形图数据的 CNN，在预测 Rose K2® 硬性角膜接触镜在角膜炎患者中的后曲率半径方面优于传统方法。

{"title":"Artificial intelligence versus conventional methods for RGP lens fitting in keratoconus","authors":"Jérémy Abadou , Simon Dahan , Juliette Knoeri , Loic Leveziel , Nacim Bouheraoua , Vincent M Borderie","doi":"10.1016/j.clae.2024.102321","DOIUrl":"10.1016/j.clae.2024.102321","url":null,"abstract":"<div><h3>Background</h3><div>To compare the efficiency of three artificial intelligence (AI) frameworks (Standard Machine Learning (ML), Multi-Layer Perceptron (MLP) and Convolution Neural Networks (CNN)) with a reference method (Mean radius of curvature (K)) to predict the posterior radius of curvature of the best-fitted rigid contact lens (RCBFL) in keratoconus eyes.</div></div><div><h3>Methods</h3><div>This retrospective study included 197 keratoconus eyes of 135 patients fitted with Rose K2® (Menicon®, Nagoya, Japan) rigid contact lenses with one or more topographies available (MS39®, CSO®, Ferrara, Italy) between January 2020 and September 2022. Two types of topographic data (indices and reconstructed maps from raw data) were used for AI analysis. Three distinct approaches were utilized for leveraging AI: Standard ML methods and MLPs based on topographic indices and CNNs based on topographic maps (i.e., corneal thickness, sagittal, and tangential maps). Seventeen AI framework’s accuracies were compared with the r<sup>2</sup> determination coefficient of linear regression between predicted and best-fitted radii. Framework accuracies were compared with the Fisher z-transformation of Pearson correlation coefficients.</div></div><div><h3>Results</h3><div>In multiple linear regression, only three topographic indices (i.e., 3- & 5-mm mean K and Kmax) were significantly associated with RCBFL (p ≤ 0.0001). Compared with the reference method (mean-K; r<sup>2</sup> = 0.36), a significantly better RCBFL prediction was achieved with Random Forest using the three topographic indices, MLP using all indices, ResNet18 CNN using anterior topographic maps and CNNs using combined parameters (0.69 ≤ r<sup>2</sup> ≤ 0.80; p < 0.05). The best accuracy was obtained with the EfficientNetB0 CNN trained with three maps (r<sup>2</sup> = 0.80).</div></div><div><h3>Conclusions</h3><div>Artificial intelligence methods, particularly CNNs, with corneal topography data of MS39® topographer, have demonstrated superiority over conventional approaches in predicting the posterior curvature radius of Rose K2® rigid contact lenses in patients with keratoconus.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102321"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective impressions with myopia control contact lenses versus single vision lenses: A systematic review and meta-analysis 近视控制隐形眼镜与单光镜片的主观感受：系统回顾和荟萃分析。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102303

Xiaona Ping, Nayuta Yoshioka, Juno Kim, Padmaja Sankaridurg

Purpose

To gain insight into patients’ visual experiences and satisfaction when using different forms of myopia control lenses.

Methods

PubMed, Cochrane Library, Embase, Scopus and Web of Science databases were searched for articles assessing subjective visual quality with myopia control lenses compared with single-vision lenses (SVLs) up to July 10, 2023. Eight-hundred-and-three articles were retrieved, reviewed and any questionnaire items on subjective impressions of lens wear were meta-analysed. Subgroup analyses were based on the magnitude of defocus (add power) of multifocal soft contact lenses (MFSCLs) and age groups. A random-effects model was employed for meta-analysis, and I² statistic used to assess the statistical heterogeneity.

Results

Nineteen articles fit the criteria, but only six articles involving MFSCLs had relevant data. MFSCLs were associated with lower subjective ratings of vision at different distances compared to SVLs (p < 0.001), but the differences were less than one unit. MFSCLs also yielded lower ratings when moving or walking and/or climbing stairs at −0.38 (−0.69 to −0.07, p = 0.02; I² = 85 %, p < 0.001) and for subjective comfort (difference of −0.23, −0.41 to −0.05, p = 0.01; I² = 63 %, p < 0.001). Subjective ratings for playing sports were not different between groups. Experience with MFSCLs was rated lower by young adults compared to children for all variables. In both children and young adults, ratings were lower with higher add compared to lower add MFSCLs.

Conclusion

Although subjective ratings for vision and comfort were lower with MFSCLs compared to SVLs, the difference was mostly less than one unit. Importantly, young adults rated their visual experience lower compared to children.

目的：了解患者在使用不同形式的近视控制镜片时的视觉体验和满意度：在 PubMed、Cochrane Library、Embase、Scopus 和 Web of Science 数据库中搜索了截至 2023 年 7 月 10 日有关近视控制镜片与单视镜 (SVL) 相比的主观视觉质量评估文章。共检索到八百零三篇文章，对其进行了审查，并对所有关于镜片佩戴主观印象的问卷项目进行了荟萃分析。根据多焦点软性隐形眼镜（MFSCLs）的散焦程度（附加功率）和年龄组进行了分组分析。采用随机效应模型进行荟萃分析，并使用 I2 统计量评估统计异质性：结果：19 篇文章符合标准，但只有 6 篇涉及超薄型角膜塑形镜的文章有相关数据。与 SVL 相比，MFSCL 在不同距离上的视力主观评分较低（P 2 = 85 %，P 2 = 63 %，P 结论：虽然视力和视力主观评分与 SVL 的主观评分存在差异，但 MFSCL 在不同距离上的视力主观评分较低：虽然与 SVL 相比，MFSCL 在视力和舒适度方面的主观评分较低，但差异大多小于一个单位。重要的是，年轻人对视觉体验的评分低于儿童。

{"title":"Subjective impressions with myopia control contact lenses versus single vision lenses: A systematic review and meta-analysis","authors":"Xiaona Ping, Nayuta Yoshioka, Juno Kim, Padmaja Sankaridurg","doi":"10.1016/j.clae.2024.102303","DOIUrl":"10.1016/j.clae.2024.102303","url":null,"abstract":"<div><h3>Purpose</h3><div>To gain insight into patients’ visual experiences and satisfaction when using different forms of myopia control lenses.</div></div><div><h3>Methods</h3><div>PubMed, Cochrane Library, Embase, Scopus and Web of Science databases were searched for articles assessing subjective visual quality with myopia control lenses compared with single-vision lenses (SVLs) up to July 10, 2023. Eight-hundred-and-three articles were retrieved, reviewed and any questionnaire items on subjective impressions of lens wear were meta-analysed. Subgroup analyses were based on the magnitude of defocus (add power) of multifocal soft contact lenses (MFSCLs) and age groups. A random-effects model was employed for meta-analysis, and I<sup>2</sup> statistic used to assess the statistical heterogeneity.</div></div><div><h3>Results</h3><div>Nineteen articles fit the criteria, but only six articles involving MFSCLs had relevant data. MFSCLs were associated with lower subjective ratings of vision at different distances compared to SVLs (p < 0.001), but the differences were less than one unit. MFSCLs also yielded lower ratings when moving or walking and/or climbing stairs at −0.38 (−0.69 to −0.07, p = 0.02; I<sup>2</sup> = 85 %, p < 0.001) and for subjective comfort (difference of −0.23, −0.41 to −0.05, p = 0.01; I<sup>2</sup> = 63 %, p < 0.001). Subjective ratings for playing sports were not different between groups. Experience with MFSCLs was rated lower by young adults compared to children for all variables. In both children and young adults, ratings were lower with higher add compared to lower add MFSCLs.</div></div><div><h3>Conclusion</h3><div>Although subjective ratings for vision and comfort were lower with MFSCLs compared to SVLs, the difference was mostly less than one unit. Importantly, young adults rated their visual experience lower compared to children.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102303"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of trial lens-fitting and software-fitting in orthokeratology for myopia control in children with high corneal eccentric value 在角膜偏心值较高的儿童近视控制中，比较角膜塑形镜的试戴和软件验配。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102334

Liuyun Chong , Ziwen Sun , Yanling Wang , Tianpu Gu , Weiping Lin , Bei Du , Ruihua Wei

Purpose

To compare the safety and efficacy of the trial lens-fitting and software-fitting in orthokeratology for myopia control in children with high corneal eccentric value.

Methods

Myopic children with high corneal eccentric value (≥0.65) receiving treatment for orthokeratology from July 2020 to January 2022 were included in this retrospective study. Only the right eyes were included. The participants were allocated into two groups: the trial lens-fitting group (n = 41) and the software-fitting group (n = 48). The uncorrected visual acuity (UCVA), corneal topography, and ocular health (Efron grading scales) were recorded at baseline, one week, two weeks, one, three, six, and 12 months after the initiation of lens wear. The axial length and endothelial cell density were assessed at baseline and after 12 months of lens wear.

Results

The success rate of the first fit in the software-fitting group and trial lens-fitting group reached 98 % and 95 %, respectively. The difference in UCVA and corneal staining were statistically insignificant between the two groups during all visits. The software-fitting group exhibited a smaller treatment zone size (radius 1.69 ± 0.21 mm vs 1.81 ± 0.16 mm, p = 0.004; area 9.13 ± 2.15 mm² vs 10.36 ± 1.82 mm², p = 0.005) and less decentration (0.58 ± 0.31 mm vs 0.74 ± 0.39 mm, p = 0.036) compared with the trial lens-fitting group. There were no significant differences in axial elongation (0.15 ± 0.12 mm vs. 0.17 ± 0.14 mm, p = 0.534) or changes in endothelial cell density (−36.63 ± 99.37/mm² vs − 13.71 ± 87.72/mm², p = 0.256) between the software-fitting group and the trial lens-fitting group at one-year follow-up visit.

Conclusion

Both fitting methods were effective and safe. However, the software-fitting method resulted in a smaller treatment zone size and less decentration.

目的：比较角膜偏心值高的近视儿童在角膜矫形术中试戴镜片验配和软件验配控制近视的安全性和有效性：这项回顾性研究纳入了 2020 年 7 月至 2022 年 1 月期间接受角膜塑形镜治疗的高角膜偏心值（≥0.65）近视儿童。研究对象仅包括右眼。参与者被分为两组：试戴镜片组（41 人）和软件验配组（48 人）。分别记录了配戴镜片后基线、一周、两周、一周、三周、六个月和十二个月的未矫正视力（UCVA）、角膜地形图和眼部健康状况（Efron评分表）。在基线和配戴镜片 12 个月后对轴向长度和内皮细胞密度进行了评估：结果：软件验配组和试戴组的首次验配成功率分别达到 98% 和 95%。在所有检查中，两组 UCVA 和角膜染色的差异均无统计学意义。与试戴镜片组相比，软件验配组的治疗区域更小（半径 1.69 ± 0.21 mm vs 1.81 ± 0.16 mm，p = 0.004；面积 9.13 ± 2.15 mm2 vs 10.36 ± 1.82 mm2，p = 0.005），分散度更低（0.58 ± 0.31 mm vs 0.74 ± 0.39 mm，p = 0.036）。在一年的随访中，软件验配组与试验镜片验配组的轴向伸长率（0.15 ± 0.12 mm vs. 0.17 ± 0.14 mm，p = 0.534）和内皮细胞密度变化（-36.63 ± 99.37/mm2 vs - 13.71 ± 87.72/mm2，p = 0.256）无明显差异：结论：两种验配方法都有效且安全。结论：两种验配方法都有效且安全，但软件验配法的治疗区更小，分散程度更低。

{"title":"Comparison of trial lens-fitting and software-fitting in orthokeratology for myopia control in children with high corneal eccentric value","authors":"Liuyun Chong , Ziwen Sun , Yanling Wang , Tianpu Gu , Weiping Lin , Bei Du , Ruihua Wei","doi":"10.1016/j.clae.2024.102334","DOIUrl":"10.1016/j.clae.2024.102334","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the safety and efficacy of the trial lens-fitting and software-fitting in orthokeratology for myopia control in children with high corneal eccentric value.</div></div><div><h3>Methods</h3><div>Myopic children with high corneal eccentric value (≥0.65) receiving treatment for orthokeratology from July 2020 to January 2022 were included in this retrospective study. Only the right eyes were included. The participants were allocated into two groups: the trial lens-fitting group (n = 41) and the software-fitting group (n = 48). The uncorrected visual acuity (UCVA), corneal topography, and ocular health (Efron grading scales) were recorded at baseline, one week, two weeks, one, three, six, and 12 months afterthe initiation of lens wear. The axial length and endothelial cell density were assessed at baseline and after 12 months of lens wear.</div></div><div><h3>Results</h3><div>The success rate of the first fit in the software-fitting group and trial lens-fitting group reached 98 % and 95 %, respectively. The difference in UCVA and corneal staining were statistically insignificant between the two groups during all visits. The software-fitting group exhibited a smaller treatment zone size (radius 1.69 ± 0.21 mm vs 1.81 ± 0.16 mm, p = 0.004; area 9.13 ± 2.15 mm<sup>2</sup> vs 10.36 ± 1.82 mm<sup>2</sup>, p = 0.005) and less decentration (0.58 ± 0.31 mm vs 0.74 ± 0.39 mm, p = 0.036) compared with the trial lens-fitting group. There were no significant differences in axial elongation (0.15 ± 0.12 mm vs. 0.17 ± 0.14 mm, p = 0.534) or changes in endothelial cell density (−36.63 ± 99.37/mm<sup>2</sup> vs − 13.71 ± 87.72/mm<sup>2</sup>, p = 0.256) between the software-fitting group and the trial lens-fitting group at one-year follow-up visit.</div></div><div><h3>Conclusion</h3><div>Both fitting methods were effective and safe. However, the software-fitting method resulted in a smaller treatment zone size and less decentration.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102334"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of midday removal and re-application of a scleral lens on fluid reservoir thickness, pre-lens tear film quality and visual acuity 中午摘除和重新佩戴巩膜透镜对储液厚度、透镜前泪膜质量和视力的影响。

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102250

Rute J. Macedo-de-Araújo , Ana Amorim-de-Sousa , José M. González-Méijome

Purpose

To investigate whether the midday removal and re-application of scleral lenses (SL) influences fluid reservoir (FR) thickness, pre-lens tear film quality and visual acuity.

Methods

Two clinical experiments were conducted. A total of 49 keratoconic eyes were evaluated for Part1 (tear film and visual acuity analysis) and 12 keratoconic eyes for Part2 (FR thickness analysis). All subjects were wearing 16.4 mm SL for more than 12-months. Tear Film Surface Quality (TFSQ) was evaluated with Medmont E300 at more than 120 min of SL wear, 10 min after SL removal (pre-corneal TFSQ) and 5 min after re-apply the same SL. High and Low Contrast Visual Acuity (HCVA and LCVA) were also assessed with the SL on eye (before and after re-application). For Part2, Anterior OCT (MOptim MOcean4000, China) measurements were taken with and without the SL (at the same time points of Part1) and three outcomes were evaluated: FR thickness, SL thickness (control measurement) and corneal thickness.

Results

Removing and re-applying a SL had a statistically significant positive impact on TFSQ, with an improvement from 0.26 ± 011 to 0.16 ± 0.08 (p = 0.001). This was accompanied by a statistically significant improvement in LogMAR HCVA (from 0.10 ± 0.09 to 0.08 ± 0.08, p < 0.001) and LCVA (from 0.39 ± 0.13 to 0.36 ± 0.13, p < 0.001). Regarding Part2 of the study, a statistically significant increase in FR thickness was observed after SL re-application (from 223.64 ± 48.08 µm to 267.81 ± 80.03 µm, p = 0.007). No changes in corneal thickness were observed.

Conclusions

Midday removal and re-application of a scleral lens positively impacted pre-lens tear film surface quality, although the observed improvement in visual acuity does not constitute a clinically significant change. Clinicians should consider that removing and reapplying a scleral lens may result in an overestimation of the fluid reservoir thickness, which could affect clinical assessments and treatment decisions.

目的：研究中午摘戴巩膜塑形镜（SL）是否会影响储液池（FR）厚度、镜前泪膜质量和视力：方法：进行了两项临床实验。第一部分（泪膜和视力分析）共评估了 49 只角膜病变眼，第二部分（泪液储库厚度分析）共评估了 12 只角膜病变眼。所有受试者均配戴 16.4 mm SL 超过 12 个月。泪膜表面质量（TFSQ）用 Medmont E300 进行评估，评估时间为戴镜超过 120 分钟、摘镜后 10 分钟（角膜前 TFSQ）和重新戴镜后 5 分钟。此外，还对戴镜后的高低对比度视力（HCVA 和 LCVA）进行了评估（重新戴镜前后）。在第 2 部分中，在使用和未使用 SL 的情况下（与第 1 部分的时间点相同）进行了前部 OCT（MOptim MOcean4000，中国）测量，并评估了三项结果：结果：结果：去除角膜塑形镜并重新涂上角膜塑形镜对 TFSQ 有显著的统计学积极影响，从 0.26 ± 011 降至 0.16 ± 0.08（p = 0.001）。与此同时，LogMAR HCVA 也有了明显改善（从 0.10 ± 0.09 降至 0.08 ± 0.08，p 结论）：中午摘除和重新配戴巩膜透镜对透镜前泪膜表面质量有积极影响，尽管观察到的视力改善并不构成有临床意义的变化。临床医生应考虑到摘除和重新配戴巩膜透镜可能会导致高估储液厚度，从而影响临床评估和治疗决策。

{"title":"Influence of midday removal and re-application of a scleral lens on fluid reservoir thickness, pre-lens tear film quality and visual acuity","authors":"Rute J. Macedo-de-Araújo , Ana Amorim-de-Sousa , José M. González-Méijome","doi":"10.1016/j.clae.2024.102250","DOIUrl":"10.1016/j.clae.2024.102250","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate whether the midday removal and re-application of scleral lenses<span> (SL) influences fluid reservoir (FR) thickness, pre-lens tear film quality and visual acuity.</span></div></div><div><h3>Methods</h3><div>Two clinical experiments were conducted. A total of 49 keratoconic eyes were evaluated for Part1Midday removal and re-application of a scleral lens positively impacted pre-lens tear film surface quality, although the observed improvement in visual acuity does not constitute a clinically significant change. Clinicians should consider that removing and reapplying a scleral lens may result in an overestimation of the fluid reservoir thickness, which could affect clinical assessments and treatment decisions.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102250"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Add-on effect of using 0.05% atropine in fast progressors of orthokeratology: A preliminary retrospective study 使用 0.05% 阿托品对角膜矫形术快速进展者的附加效果：初步回顾性研究

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-02-01 DOI: 10.1016/j.clae.2024.102282

Longbo Wen , Hong Liu , Qinglin Xu , Wei Pan , Zhenghua Lin , Zhigang Xiao , Zhikuan Yang , Weizhong Lan , Zhao Chen

Purpose

To investigate the potential benefit of combining orthokeratology (OK) lenses with 0.05% atropine ophthalmic solution on the efficacy of myopia control in the fast progressors of OK.

Methods

Average axial length (AL) elongation of both eyes in 70 participants using OK lenses alone or OK lenses combined with 0.05 % atropine ophthalmic solution was retrospectively reviewed. During the observation period (phase 1), all participants exhibited an AL elongation that exceeded 0.15 mm over a 6-month period or 0.3 mm over a 12-month period. Subsequently, the participants were divided into two groups: one group received nightly 0.05 % atropine ophthalmic solution in addition to OK lenses for another 1 year (OKA), while the other group continued using OK lenses alone (phase 2). The changes in AL elongation over time and the differences in AL elongation between the two groups were then compared.

Results

The baseline and phase 1 demographics and characteristics of the participants was similar between the two groups (all p > 0.05). when considering a one-year timeframe, the OKA group displayed a significantly less AL elongation compared to the OK group (0.14 ± 0.13 mm vs 0.27 ± 0.12 mm, p < 0.001). Within the OKA group, the AL elongation in the second half of the year was significantly faster than in the first half (0.12 ± 0.11 mm vs 0.02 ± 0.14 mm, p = 0.01). Conversely, there was no significant difference in AL elongation between the OK group in the first and second half of the year (0.12 ± 0.07 mm vs 0.15 ± 0.08 mm, p = 0.71). The combination of 0.05 % atropine ophthalmic solution had a significant effect on 1-year AL elongation (p < 0.001).

Conclusions

This study provided preliminary evidence that the combination of OK lenses and 0.05% atropine ophthalmic solution can significantly enhance the effectiveness of myopia control.

目的：研究角膜塑形镜（OK镜）与0.05%阿托品眼药水结合使用对快速进展期OK镜患者近视控制效果的潜在益处：方法：对70名单独使用OK镜片或OK镜片与0.05%阿托品眼药水混合使用的患者的双眼平均轴长（AL）伸长率进行回顾性研究。在观察期间（第 1 阶段），所有参与者的角膜屈光度（AL）伸长量在 6 个月内超过 0.15 毫米，或在 12 个月内超过 0.3 毫米。随后，参与者被分为两组：一组在每晚使用 0.05 % 阿托品眼药水的同时配戴 OK 镜，为期 1 年（OKA）；另一组继续单独配戴 OK 镜（第 2 阶段）。然后比较两组间 AL 伸长率随时间的变化以及 AL 伸长率的差异：结果：两组参与者的基线和第一阶段的人口统计学和特征相似（均 p > 0.05）。当考虑到一年的时间框架时，OKA 组的 AL 伸长率明显低于 OK 组（0.14 ± 0.13 mm vs 0.27 ± 0.12 mm，p 结论：该研究初步证明了在第一阶段中使用 OKA 和 OKA 镜片可以减少 AL 伸长率：本研究提供了初步证据，证明将 OK 镜片和 0.05% 阿托品眼药水结合使用，可显著提高近视控制效果。

{"title":"Add-on effect of using 0.05% atropine in fast progressors of orthokeratology: A preliminary retrospective study","authors":"Longbo Wen , Hong Liu , Qinglin Xu , Wei Pan , Zhenghua Lin , Zhigang Xiao , Zhikuan Yang , Weizhong Lan , Zhao Chen","doi":"10.1016/j.clae.2024.102282","DOIUrl":"10.1016/j.clae.2024.102282","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the potential benefit of combining orthokeratology (OK) lenses with 0.05% atropine ophthalmic solution on the efficacy of myopia control in the fast progressors of OK.</div></div><div><h3>Methods</h3><div>Average axial length (AL) elongation of both eyes in 70 participants using OK lenses alone or OK lenses combined with 0.05 % atropine ophthalmic solution was retrospectively reviewed. During the observation period (phase 1), all participants exhibited an AL elongation that exceeded 0.15 mm over a 6-month period or 0.3 mm over a 12-month period. Subsequently, the participants were divided into two groups: one group received nightly 0.05 % atropine ophthalmic solution in addition to OK lenses for another 1 year (OKA), while the other group continued using OK lenses alone (phase 2). The changes in AL elongation over time and the differences in AL elongation between the two groups were then compared.</div></div><div><h3>Results</h3><div>The baseline and phase 1 demographics and characteristics of the participants was similar between the two groups (all p > 0.05). when considering a one-year timeframe, the OKA group displayed a significantly less AL elongation compared to the OK group (0.14 ± 0.13 mm vs 0.27 ± 0.12 mm, p < 0.001). Within the OKA group, the AL elongation in the second half of the year was significantly faster than in the first half (0.12 ± 0.11 mm vs 0.02 ± 0.14 mm, p = 0.01). Conversely, there was no significant difference in AL elongation between the OK group in the first and second half of the year (0.12 ± 0.07 mm vs 0.15 ± 0.08 mm, p = 0.71). The combination of 0.05 % atropine ophthalmic solution had a significant effect on 1-year AL elongation (p < 0.001).</div></div><div><h3>Conclusions</h3><div>This study provided preliminary evidence that the combination of OK lenses and 0.05% atropine ophthalmic solution can significantly enhance the effectiveness of myopia control.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102282"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0