Contact Lens & Anterior Eye最新文献_第2页

Proteomic analysis of tear fluid: Comparative short-term effects of scleral lenses and rigid corneal lenses wear in ametropic healthy adults 泪液的蛋白质组学分析：在屈光健康成人中，巩膜镜片和硬性角膜镜片配戴的短期效果比较。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102507

Zhe Zhang , Li Zeng , Qihua Le , Yanze Yu , Jiaqi Zhou , Feng Xue , Xingtao Zhou , Jiaxu Hong , Zhi Chen

Purpose

The aim of this study was to evaluate the effect of scleral lenses (SLs) on the ocular surface of healthy individuals and explore potential molecular changes in the tear fluid reservoir associated with this form of contact lens.

Methods

Forty-one healthy Chinese subjects were enrolled in the prospective study and assigned to wear SLs or rigid corneal lenses (RCL), and their ocular surface was evaluated at various time points over one month period. Hyperemia, tear film stability, and molecular changes in tear fluid were assessed. Tandem mass tagging proteomics analysis was used to identify differentially expressed proteins in tears after wearing different lenses.

Results

There were no statistically significant differences observed in in the hyperemia index of the nasal and temporal ciliary vessel areas, as well as the nasal and temporal conjunctival vessel areas between groups. The difference in tear film stability between the two groups was not statistically significant. However, proteomic analysis of tear samples revealed 397 differentially expressed proteins in the SLs group, including pro-inflammatory markers such as interleukins. Pathway analysis identified upregulation of inflammation-related pathways.

Conclusions

SLs wear does not significantly impact hyperemia and tear film stability compared to RCL. Nevertheless, at the molecular level, there is evidence showing an underlying inflammatory response. These findings require continued research to elucidate the clinical implications of these molecular changes and to guide SLs fitting.

目的：本研究的目的是评估巩膜隐形眼镜（SLs）对健康个体眼表的影响，并探讨与这种形式的隐形眼镜相关的泪液储层的潜在分子变化。方法：41名健康的中国受试者被纳入前瞻性研究，并被分配佩戴SLs或刚性角膜镜片（RCL），并在一个月内的不同时间点对其眼表进行评估。充血、泪膜稳定性和泪液分子变化进行了评估。串联质量标记蛋白质组学分析用于鉴定佩戴不同镜片后泪液中差异表达的蛋白质。结果：两组患者鼻、颞睫血管区充血指数、鼻、颞结膜血管区充血指数比较，差异均无统计学意义。两组泪膜稳定性差异无统计学意义。然而，泪液样本的蛋白质组学分析显示，在SLs组中有397种差异表达蛋白，包括促炎标志物，如白细胞介素。通路分析确定了炎症相关通路的上调。结论：与RCL相比，SLs磨损对充血和泪膜稳定性没有显著影响。然而，在分子水平上，有证据表明存在潜在的炎症反应。这些发现需要继续研究，以阐明这些分子变化的临床意义，并指导SLs的匹配。

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引用次数: 0

Reply to letter RE “Improved control efficacy of a novel aspherical orthokeratology lens compared with the traditional three-zone spherical lens in a single-blind randomized clinical trial” 给编辑的信。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102518

引用次数: 0

Effectiveness of DIMS combined with atropine and orthokeratology in a real-world setting in China DIMS联合阿托品和角膜塑形术在中国的实际应用效果。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102473

Desheng Song , Yanxu Chen , Jiaqi Yao, Juan Chen

Background and objectives

Myopia cases have markedly increased worldwide, particularly in younger individuals. This study evaluates the effect of defocus incorporated multiple segments (DIMS) lens combined with atropine (DIMSA) in the control of myopia progression versus orthokeratology (ortho-k) lenses.

Methods

In this non-randomized controlled clinical study, 180 eyes in 180 myopic children treated at the Nanjing Children’s Hospital between January 2022 and February 2023 were included. According to the preferences of patients and their guardians, the participants were divided into the DIMSA and ortho-k groups, with 90 cases (90 eyes) each. Totally 161 patients in both groups met the inclusion and exclusion criteria, including 88 and 73 in the DIMSA and ortho-k groups, respectively. Right eye parameters were analyzed. Both groups were compared in terms of change in axial length (AL), AL negative growth rate and AL elongation rate after a one-year visit.

Results

No significant differences were found in baseline features other than age between the DIMSA and ortho-k groups. After a one-year treatment, no statistically significant difference was found in axial elongation (AE) between the two groups. After adjustment for baseline age, axial elongations in the DIMSA and ortho-k groups were 0.14 ± 0.18 mm and 0.20 ± 0.18 mm (P = 0.025), respectively. Baseline age was the only factor impacting the axial control efficacy of DIMSA and ortho-k lenses, with a negative association between AE and age in both groups and a positive association between spherical equivalent refraction (SER) increase and baseline age in the DIMSA group. The DIMSA group exhibited higher AL negative growth and AL slow growth (≤0.15 mm) rates after one year compared with the ortho-k lens group (P = 0.008 and P = 0.004, respectively).

Conclusions

DIMSA demonstrated marginally superior myopia control efficacy compared to ortho-k lenses in children with mild to moderate myopia in a real-world setting in China.

背景和目的：近视病例在世界范围内显著增加，特别是在年轻人中。本研究评估了离焦合并多节段（DIMS）晶状体联合阿托品（DIMSA）与角膜塑形（orthokeratology）镜片在控制近视进展中的效果。方法：在这项非随机对照临床研究中，纳入2022年1月至2023年2月在南京儿童医院就诊的180名近视儿童的180只眼。根据患者及其监护人的喜好，将参与者分为DIMSA组和ortho-k组，每组90例（90只眼）。两组共161例患者符合纳入和排除标准，其中DIMSA组88例，ortho-k组73例。分析右眼参数。两组在随访一年后比较轴向长度（AL）、AL负生长率和AL伸长率的变化。结果：除年龄外，DIMSA组和ortho-k组的基线特征无显著差异。治疗一年后，两组间的轴向伸长（AE）无统计学差异。调整基线年龄后，DIMSA组和ortho-k组的轴向伸长分别为0.14±0.18 mm和0.20±0.18 mm （P = 0.025）。基线年龄是影响DIMSA和orthok透镜轴向控制效果的唯一因素，两组的AE与年龄呈负相关，而DIMSA组的球面等效折射（SER）增加与基线年龄呈正相关。与orthok lens组相比，DIMSA组在1年后AL负增长和AL慢增长（≤0.15 mm）率更高（P = 0.008和P = 0.004）。结论：在中国的现实环境中，DIMSA在轻度至中度近视儿童中的控制效果略优于orthok镜片。

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引用次数: 0

Predicting contact lens discomfort from meibomian gland morphology and function 从睑板腺形态和功能预测隐形眼镜不适。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102480

Fatima Iqbal , Eric B Papas , Fiona Stapleton , Waleed M. Alghamdi , Amy Ruan , Karuna Darvesh , Lucy Nguyen , Jacqueline Tan

Purpose

To develop and validate a model to predict contact lens discomfort (CLD) using features of the meibomian glands (MG).

Methods

This study consisted of three parts: (i) 50 meibography images from contact lens wearers and non-wearers were assessed to distinguish features of interest between the groups to develop an automated algorithm which was tested on 154 images from CLD participants (ii) A multivariable model was constructed with a separate population of 84 lens wearers using imaging features and ocular surface signs to predict Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) score (iii) The model was validated on two independent sets of images using Bland-Altman comparisons between actual and predicted CLDEQ-8 scores.

Results

Part I: Intergland distance and width of the gland at the lid margin, centre and distal end were identified as features distinguishing between lens wearers and non-wearers. Part II: In univariate analysis, CLDEQ-8 scores were negatively associated with gland width at the lid margin (r = −0.52, p = 0.01) and lipid layer thickness (r = −0.40, p < 0.05) and positively associated with tear break-up time (r = 0.51, p < 0.001), MG expressibility (r = 0.35, p = 0.01), and intergland distance at the lid margin (r = 0.73, p = 0.02). The multivariable regression model accounted for 68 % (R² = 0.68, p < 0.05) of the variance in CLDEQ-8 scores. Part III: The mean difference (bias) between the predicted and actual CLDEQ-8 score was −0.1 with limits of agreement of ± 2.8 units.

Conclusion

Morphometric features of MG can predict CLDEQ-8 score in lens wearers with reasonable accuracy. This approach may be a suitable screening tool in early detection and to understand the natural history of CLD.

目的：建立并验证一种利用睑板腺（MG）特征预测隐形眼镜不适（CLD）的模型。方法：本研究由三部分组成：(i)评估了来自隐形眼镜佩戴者和非佩戴者的50张meibography图像，以区分组间感兴趣的特征，并开发了一种自动算法，该算法对来自CLD参与者的154张图像进行了测试。（ii）构建了一个多变量模型，包括84名隐形眼镜佩戴者，使用成像特征和眼表体征来预测隐形眼镜干眼症问卷-8 （CLDEQ-8）得分Bland-Altman比较实际和预测的CLDEQ-8分数。结果：第一部分：眼睑边缘、中心和远端腺体间距离和宽度被确定为区分配戴者和非配戴者的特征。第二部分：在单变量分析中，CLDEQ-8评分与眼睑边缘腺体宽度（r = -0.52, p = 0.01）和脂质层厚度（r = -0.40, p 2 = 0.68, p）呈负相关。结论：MG形态计量学特征可以合理准确地预测晶状体佩戴者的CLDEQ-8评分。这种方法可能是早期发现和了解CLD自然历史的一种合适的筛选工具。

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引用次数: 0

A survey of attitudes and clinical behaviour of UK eyecare practitioners towards fitting contact lenses for children and young people 一项调查的态度和临床行为的英国眼科医生对适合儿童和年轻人的隐形眼镜。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102470

Sophie Coverdale , Edward Mallen , Matthew Cufflin , Michael Bowen , Teresa Lewandowski , Neema Ghorbani-Mojarrad

Purpose

This study explored the attitudes and prescribing behaviours of UK eyecare practitioners (ECPs) toward fitting contact lenses (CLs) for patients under 18, and whether these have been influenced by the growing availability of myopia control options.

Methods

An online survey was conducted in 2023 with UK-based optometrists and contact lens opticians (CLOs). It examined minimum fitting ages for different CL types, key decision-making factors when prescribing for paediatrics, and changes in practitioners’ willingness to fit CLs for children. Comparisons were made to a prior iteration of the survey in 2014.

Results

A total of 316 ECPs (248 optometrists, 68 CLOs) completed the survey, with a median of 16 years of experience. Patients under age 18 comprised an estimated 37.2 % of respondents’ CL patients, dropping to 6.2 % for those under age 10. All respondents considered soft CLs suitable for under-18 s, with a median starting age of 8–9 years; rigid corneal lenses were deemed suitable from a significantly higher age of 10–12 years (p < 0.001). CLOs were more willing than optometrists to fit both lens types at earlier ages (p < 0.05) and rated a child’s age as less influential in decision-making (4.9/10 vs. 6.2/10 respectively, p < 0.001). In general, the child’s motivation was the most important factor (9.1/10), while sex was the least (1.8/10). Myopia control was a key consideration (8.4/10), and 38.6 % of ECPs said they had greater willingness to fit CLs for children due to increased access to myopia control options. The proportion of optometrists willing to fit a child under age 8 increased from 12.7 % in 2014 to 39.1 % in 2023.

Conclusions

UK ECPs are generally supportive of CL wear in under-18 s, with myopia control increasingly influencing prescribing. CLOs appear more proactive in paediatric fittings, suggesting a need to enhance optometrists’ training to improve confidence in prescribing for younger patients.

目的：本研究探讨了英国眼科医生（ECPs）对18岁以下患者配戴隐形眼镜（CLs）的态度和处方行为，以及这些态度和行为是否受到越来越多的近视控制选择的影响。方法：于2023年对英国验光师和隐形眼镜验光师（CLOs）进行在线调查。它检查了不同CL类型的最低适合年龄，儿科处方时的关键决策因素，以及从业人员适合儿童CL的意愿的变化。与2014年的调查结果进行了比较。结果：共有316名ECPs（248名验光师，68名clo）完成了调查，平均经验为16年。18岁以下的患者估计占应答者CL患者的37.2%，而10岁以下的患者则降至6.2%。所有受访者都认为软CLs适合18岁以下的人，中位数起始年龄为8-9岁；结论：英国ECPs普遍支持18岁以下儿童配戴晶状体眼镜，近视控制对处方的影响越来越大。CLOs在儿科配光方面显得更加主动，这表明需要加强验光师的培训，以提高为年轻患者开处方的信心。

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引用次数: 0

Effect of apical clearance rigid corneal contact lens fitting on keratoconus progression: a controlled longitudinal analysis 根尖间隙硬性角膜接触镜配戴对圆锥角膜进展的影响：一项纵向对照分析。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102449

Tsung-Hsien Tsai , Jui-Hung Hsu , Chi-Chin Sun , Ching-Hsi Hsiao , Jiahn-Shing Lee , Ken-Kuo Lin

Purpose

To evaluate the impact of apical clearance rigid corneal contact lens (RCCL) fitting on keratoconus (KC) progression compared to untreated KC patients over a 12-month period.

Methods

This retrospective, controlled longitudinal study included 237 eyes with KC from two centers between 2018 and 2023. Following propensity score matching for baseline age and maximum keratometry (K_max), 31 eyes each were assigned to untreated and RCCL groups. RCCLs were fitted using the apical clearance method. Assessments at baseline, 3, 6, and 12 months included best-corrected visual acuity (BCVA), Scheimpflug corneal tomography and higher-order aberrations (HOAs). KC progression was defined by any of the following: an increase in K_max or anterior steep keratometry (K2) of >1.0 D, a decrease in thinnest corneal thickness (TCT) of > 10 μm, or a loss of >1 line of BCVA. Longitudinal changes were analyzed using generalized estimating equations (GEE).

Results

No significant differences in BCVA, tomographic indices, or HOAs were observed between the untreated and RCCL groups at baseline or during follow-up at 3 and 12 months (all p > 0.05). KC progression rates were comparable between the groups, occurring in 12.9 % of untreated eyes and 19.35 % of RCCL treated eyes by 12 months (p = 0.731). GEE analysis revealed a significant reduction in K2 at 3 months within the RCCL group (p = 0.003); however, no other significant longitudinal differences were detected within or between groups at any follow–up period.

Conclusion

Apical clearance RCCL fitting did not significantly affect overall KC progression compared with no treatment over 12 months. However, the significant reduction in K2 at 3 months in the RCCL group suggests that one week of contact lens discontinuation may not be sufficient for the cornea to fully return to its natural state.

目的：评估顶间隙硬性角膜接触镜（RCCL）配戴对圆锥角膜（KC）进展的影响，并与未治疗的KC患者进行比较。方法：本回顾性、对照纵向研究包括2018年至2023年来自两个中心的237只KC眼。根据基线年龄和最大角膜度数（Kmax）的倾向评分匹配，各31只眼睛被分配到未治疗组和RCCL组。采用根尖间隙法拟合rccl。基线、3、6和12个月的评估包括最佳矫正视力（BCVA）、Scheimpflug角膜断层扫描和高阶像差（HOAs）。KC进展通过以下任何一项来定义：Kmax或前角陡角膜密度（K2）增加>.0 D，最薄角膜厚度（TCT）减少> 10 μm，或BCVA失去>1线。采用广义估计方程（GEE）分析纵向变化。结果：治疗组和RCCL组在基线时或随访3个月和12个月时的BCVA、断层扫描指数或hoa均无显著差异（p < 0.05）。两组间KC进展率具有可比性，12个月时，未治疗组的KC进展率为12.9%，RCCL治疗组的KC进展率为19.35% （p = 0.731）。GEE分析显示，RCCL组在3个月时K2显著降低（p = 0.003）；然而，在任何随访期间，在组内或组间均未发现其他显著的纵向差异。结论：与未治疗相比，根尖清除RCCL安装在12个月内对KC的总体进展没有显著影响。然而，在RCCL组中，3个月时K2的显著降低表明，停用隐形眼镜一周可能不足以使角膜完全恢复到自然状态。

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引用次数: 0

Dehydration and physicochemical changes in myopia control contact lenses: influence of material and maintenance solutions 近视控制隐形眼镜的脱水和理化变化：材料和保养液的影响。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102478

Veronica Noya-Padin , Hugo Pena-Verdeal , Pedro V. Rodrigues , Ana Vera Machado , Eva Yebra-Pimentel , Madalena Lira

Purpose

To assess the dehydration rate in different myopia control contact lenses (CLs) and the physicochemical changes that occur after exposure to different maintenance solutions.

Methods

First, the dehydration rate of CLs and its impact on refractive index and diameter were evaluated in three myopia control CLs models (MiSight 1 Day, Bloom Day, and MYLO). Measurements were taken immediately after the CL was removed from the blister and at 5-min intervals over a 30-min period. Second, the effect of different maintenance solutions on the physicochemical properties of monthly replacement myopia control CLs (MYLO) with different diameters were assessed. Refractive index, water content, diameter, lens surface hydrophobicity, and dynamic mechanical properties were measured immediately after the CL was removed from the blister and again after 12 h of immersion in each of the three maintenance solutions studied (Hidro Health HA, OPTI-Free PureMoist and Biotrue).

Results

The dehydration rate exhibited significant disparities among the CLs examined, with daily replacement CLs (MiSight 1 Day and Bloom Day) demonstrating the fastest dehydration and, consequently, the most significant change in refractive index. In contrast, MYLO CLs exhibited the greatest reduction in diameter. When assessing the impact of maintenance solutions on MYLO properties, changes were observed in all evaluated parameters, except for mechanical properties. These changes varied depending on the maintenance solution used and the diameter of CL.

Conclusion

Myopia control CLs can undergo dehydration and changes due to the solutions used for their care, which may significantly affect their physicochemical properties, lens performance, comfort, and stability. Therefore, careful consideration should be given to the properties of the CL material and the maintenance solutions properties to optimize the user experience and ensure consistent lens behavior over time.

目的：评价不同近视控制隐形眼镜（CLs）的脱水率及不同保养液对其脱水率的影响。方法：首先，在MiSight 1 Day、Bloom Day和MYLO 3种近视控制CLs模型中评估CLs脱水率及其对屈光指数和直径的影响。在将CL从水疱中取出后立即进行测量，每隔5分钟进行一次测量，持续30分钟。其次，评估不同维持液对每月更换的不同直径的近视控制CLs （MYLO）理化性能的影响。在将CL从水泡中取出后立即测量折射率、含水量、直径、镜片表面疏水性和动态力学性能，并在所研究的三种维护溶液（Hidro Health HA、OPTI-Free PureMoist和Biotrue）中分别浸泡12小时后再次测量。结果：在检查的CLs中，脱水率表现出显著的差异，每日更换的CLs （MiSight 1 Day和Bloom Day）显示出最快的脱水，因此，折射率变化最显著。相比之下，MYLO CLs的直径减小幅度最大。当评估维护溶液对MYLO性能的影响时，除了机械性能外，所有被评估的参数都发生了变化。这些变化取决于所使用的维护溶液和CL的直径。结论：控制近视的晶状体可因护理液的不同而发生脱水和变化，从而显著影响晶状体的理化性质、晶状体性能、舒适度和稳定性。因此，应仔细考虑CL材料的性能和维护解决方案的性能，以优化用户体验，并确保镜片的性能随着时间的推移保持一致。

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引用次数: 0

Comparative in vitro efficacy of ivermectin, lotilaner, lime sulfur, tea tree oil, and lemongrass oil against Demodex folliculorum 伊维菌素、洛替拉、石灰硫、茶树油和柠檬草油对毛囊蠕形螨的体外药效比较。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102481

G. Demirci, S. Karaman Erdur

Aim

Excessive proliferation of Demodex folliculorum has been implicated in blepharitis and other inflammatory ocular conditions. Given the growing interest in safer and more effective alternatives to current treatments, this study aimed to evaluate and compare the in vitro acaricidal efficacy of lemongrass oil, tea tree oil (TTO), ivermectin 1%, lotilaner ophthalmic solution 0.25% (Xdemvy), lime sulfur, and olive oil (used as a negative control) against Demodex folliculorum.

Materials and Methods

Adult Demodex folliculorum mites were isolated from eyelash samples of blepharitis patients. Lashes were epilated under slit-lamp guidance using sterile forceps. The most motile mite per slide was selected and placed under a digital light microscope (40 × ) with 20 μL of each test agent. Mite viability was recorded in real time; death was defined as the cessation of all movement for 60 s despite mechanical stimulation. Ten mites were tested per group. Survival time data were statistically analyzed.

Results

Lotilaner 0.25 % exhibited the shortest median survival time (12.0 min), followed by ivermectin 1 % (14.0 min), lemongrass oil (14.5 min), lime sulfur (22.0 min), and TTO 5 % (27.0 min). Olive oil showed minimal acaricidal activity (median: 360.0 min). Lemongrass oil achieved the fastest complete kill time, while lotilaner demonstrated the lowest median survival time.

Conclusion

Lotilaner ophthalmic solution 0.25% demonstrated the shortest median survival time, followed closely by ivermectin 1% and lemongrass oil. While lemongrass achieved complete mite mortality most rapidly, lotilaner was most consistent in reducing survival time. These in vitro findings suggest that both pharmaceutical and natural agents may possess promising acaricidal activity. Further in vivo studies are warranted to confirm these findings and explore safety and clinical applicability.

目的：卵泡蠕形螨的过度增殖与眼睑炎和其他眼部炎症有关。鉴于人们对更安全、更有效替代现有治疗方法的兴趣日益增加，本研究旨在评估和比较柠檬草油、茶树油（TTO）、1%伊维菌素、0.25%洛替拉纳眼液（Xdemvy）、石灰硫和橄榄油（作为阴性对照）对毛囊蠕形螨的体外杀螨效果。材料与方法：从眼炎患者的睫毛标本中分离得到毛囊蠕形螨成虫。在裂隙灯引导下使用无菌钳对睫毛进行脱毛。选择单张载玻片上最活跃的螨，在40 ×数码光学显微镜下，每种试验剂20 μL。实时记录螨活力；死亡定义为尽管有机械刺激，但所有运动停止60秒。每组10只。对生存时间数据进行统计学分析。结果：lotillaner 0.25%的中位生存时间最短（12.0 min），其次是伊维菌素1% （14.0 min）、柠檬草油（14.5 min）、石灰硫（22.0 min）和toto5 % （27.0 min）。橄榄油的杀螨活性最小（中位数：360.0 min）。柠檬草精油的完全杀灭时间最快，而洛地兰的中位存活时间最短。结论：0.25%洛替拉纳眼液中位生存时间最短，其次为1%伊维菌素和柠檬草油。虽然柠檬草最迅速地实现了螨虫的完全死亡，但洛地laner在减少存活时间方面最一致。这些体外实验结果表明，药物和天然药剂都可能具有良好的杀螨活性。需要进一步的体内研究来证实这些发现，并探索安全性和临床适用性。

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引用次数: 0

Letter to the editor RE “Improved control efficacy of a novel aspherical orthokeratology lens compared with the traditional three-zone spherical lens in a single-blind randomized clinical trial” 致编辑RE的信“一项单盲随机临床试验中新型非球面角膜塑形镜与传统三区球面晶状体相比控制效果的改善”。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102495

Dr. Parth Aphale, Himanshu Shekhar, Shashank Dokania

引用次数: 0

Characterizing power profiles of a concentric ring multifocal contact lens for myopia management: a novel approach 一种用于近视治疗的同心环多焦点隐形眼镜的功率分布特征：一种新方法。

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye

Pub Date : 2025-12-01 DOI: 10.1016/j.clae.2025.102454

Annabelle J. Mawhinney , Phillip J. Buckhurst , Craig McNeile , Stephen D. Hall , Hetal D. Buckhurst

This study presents a systematic method for characterizing power profiles of concentric ring multifocal contact lenses (MFCL), specifically the MiSight® lens used in myopia management, and evaluates the potential of Multivariate Adaptive Regression Spline (MARS) modelling to extrapolate profiles across a full dioptric range.

Power profiles of eleven MiSight® lenses (−0.25D, then −1.00D to −10.00D in 1.00D steps) were measured using the NIMOevo® system. MiSight® lenses comprise four concentric zones, with zones 2 and 4 providing additional plus power. Centre thickness (CT) was measured using an immersive spectral-domain Optical Coherence Tomographer. Zonal boundaries were determined as asymptotes of a four-parameter sigmoidal function fitted to junctions between zones, average power within each zone was calculated between these boundaries.

MARS was trained on the measured power profiles and used to generate theoretical power profiles for intermediate powers. These were validated against independently measured lenses with matching labelled powers (−1.50D, −3.50D and −6.50D).

The proposed method identified consistent zonal boundaries across labelled powers, with minor power-dependent variations. CT correlated significantly with labelled power (r = 0.78). Zone 2 addition powers were consistent, while zone 4 demonstrated a decreasing trend with increasing negative power. The MARS accurately modeled boundary locations and addition powers.

This framework offers a systematic approach for analyzing zonal MFCL power profiles, addressing the method for determining zonal boundaries. Additional plus power provided by MiSight® lenses varies across the two zones, with a pronounced effect of reducing addition power in zone 4. MARS modelling allowed extrapolation of power profiles and warrants further investigation.

本研究提出了一种系统的方法来表征同心圆多焦隐形眼镜（MFCL）的功率分布，特别是用于近视治疗的MiSight®隐形眼镜，并评估了多元自适应回归样条（MARS）模型在整个屈光度范围内推断轮廓的潜力。使用NIMOevo®系统测量了11个MiSight®镜头（-0.25D，然后-1.00D至-10.00D，分1.00D步）的功率分布。MiSight®镜头包括四个同心区域，区域2和4提供额外的附加功率。中心厚度（CT）采用沉浸式光谱域光学相干层析仪测量。区域边界被确定为四参数s型函数的渐近线，拟合到区域之间的连接处，计算这些边界之间每个区域内的平均功率。根据测量的功率分布对MARS进行训练，并用于生成中等功率的理论功率分布。这些是通过独立测量的具有匹配标记功率（-1.50D, -3.50D和-6.50D）的透镜进行验证的。所提出的方法确定了标记功率之间一致的区域边界，具有较小的功率依赖变化。CT与标记功率显著相关（r = 0.78）。区域2的加法幂基本一致，而区域4的加法幂随负幂的增加呈下降趋势。MARS精确地模拟了边界位置和加法。该框架提供了一个系统的方法来分析层间MFCL功率分布，解决了确定层间边界的方法。MiSight®透镜提供的额外附加功率在两个区域之间有所不同，在区域4中具有明显的降低附加功率的效果。火星模型允许外推功率分布，并保证进一步调查。

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引用次数: 0