首页 > 最新文献

Brazilian Journal of Otorhinolaryngology最新文献

英文 中文
Effectiveness of hypertonic saline irrigation following functional endoscopic sinus surgery: a systematic review and meta-analysis 功能性内窥镜鼻窦手术后高渗盐水冲洗的效果:系统综述和荟萃分析
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-11-05 DOI: 10.1016/j.bjorl.2024.101517
Adriano Damasceno Lima , Rodolfo Baptista Giffoni , Julieta Arguelles-Hernandez , Gabriele Santos , Victor L.J.C. Sena , Ricardo S. Aguiar , Marcelo L.S. Cruz , Maria E.P. Dalmaschio , Marcio Nakanishi

Objectives

This study aimed to clarify the impact of hypertonic solutions on various outcomes, including persistence or reduction of nasal crusts, polypoid edema, and postoperative inflammatory symptoms.

Methods

We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials for studies comparing hypertonic with isotonic saline irrigation after FESS in adult patients with Chronic Rhinosinusitis (CRS). Outcomes were polypoid mucosa, nasal crusts, and variation from the baseline of Sino-Nasal Outcome Test (SNOT) 20/22 and Visual Analog Scale (VAS). For statistical analysis, we used RevMan 5.4.1, and assessed heterogeneity with I2 statistics.

Results

We included a total of 479 patients from 7 studies. In the hypertonic saline group, there was a reduction in the nasal crust Risk Ratio (RR) (RR = 0.65; 95% CI 0.49 to 0.87; p = 0.004; I2 = 0%) after 30–45 days and severe crusts at 14–21 days (RR = 0.59; 95% CI 0.38 to 0.91; p = 0.02; I2 = 0%). Additionally, the persistence of polypoid mucosa was lower in the intervention arm (RR = 0.53; 95% CI 0.43 to 0.65; p < 0.00001; I2 = 0%) after 14–21 days. In the symptomatic evaluation hypertonic saline group showed an improvement in postoperative symptoms by a VAS Mean Difference (MD) (MD = −5; 95% CI −5.77 to −4.24; p < 0.00001; I2 = 0%) and a SNOT 20/22 Standard Mean Difference (SMD) (SMD = −1.65; 95% CI −2.7 to −0.61; p = 0.002; I2 = 93%) reduction from baseline in 30–45 days after the surgery.

Conclusion

Hypertonic saline showed a superior improvement in postoperative evaluation by means of nasal crusting, mucosal healing aspect, and nasal inflammatory symptoms compared with isotonic saline irrigation.
本研究旨在阐明高渗溶液对各种结果的影响,包括鼻痂、息肉样水肿和术后炎症症状的持续或减轻。方法我们检索了 PubMed、Embase 和 Cochrane Central Register of Controlled Trials 等文献,比较了慢性鼻窦炎(CRS)成人患者 FESS 术后高渗和等渗生理盐水灌洗的研究。研究结果包括息肉状粘膜、鼻腔结痂、中鼻结果测试(SNOT)20/22 和视觉模拟量表(VAS)与基线的差异。我们使用 RevMan 5.4.1 进行了统计分析,并用 I2 统计量评估了异质性。在高渗盐水组中,30-45 天后鼻痂风险比 (RR) 降低(RR = 0.65;95% CI 0.49 至 0.87;p = 0.004;I2 = 0%),14-21 天后严重鼻痂风险比降低(RR = 0.59;95% CI 0.38 至 0.91;p = 0.02;I2 = 0%)。此外,14-21 天后,干预组的息肉状粘膜持续性较低(RR = 0.53;95% CI 0.43 至 0.65;p < 0.00001;I2 = 0%)。在症状评估中,高渗盐水组的术后症状有所改善,VAS平均差(MD)(MD = -5; 95% CI -5.77 to -4.24; p < 0.00001; I2 = 0%)和SNOT 20/22标准平均差(SMD)(SMD = -1.65; 95% CI -2.7 to -0.结论与等渗盐水灌洗相比,高渗盐水通过鼻腔结痂、粘膜愈合方面和鼻腔炎症症状对术后评估有更好的改善作用。
{"title":"Effectiveness of hypertonic saline irrigation following functional endoscopic sinus surgery: a systematic review and meta-analysis","authors":"Adriano Damasceno Lima ,&nbsp;Rodolfo Baptista Giffoni ,&nbsp;Julieta Arguelles-Hernandez ,&nbsp;Gabriele Santos ,&nbsp;Victor L.J.C. Sena ,&nbsp;Ricardo S. Aguiar ,&nbsp;Marcelo L.S. Cruz ,&nbsp;Maria E.P. Dalmaschio ,&nbsp;Marcio Nakanishi","doi":"10.1016/j.bjorl.2024.101517","DOIUrl":"10.1016/j.bjorl.2024.101517","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to clarify the impact of hypertonic solutions on various outcomes, including persistence or reduction of nasal crusts, polypoid edema, and postoperative inflammatory symptoms.</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials for studies comparing hypertonic with isotonic saline irrigation after FESS in adult patients with Chronic Rhinosinusitis (CRS). Outcomes were polypoid mucosa, nasal crusts, and variation from the baseline of Sino-Nasal Outcome Test (SNOT) 20/22 and Visual Analog Scale (VAS). For statistical analysis, we used RevMan 5.4.1, and assessed heterogeneity with I<sup>2</sup> statistics.</div></div><div><h3>Results</h3><div>We included a total of 479 patients from 7 studies. In the hypertonic saline group, there was a reduction in the nasal crust Risk Ratio (RR) (RR = 0.65; 95% CI 0.49 to 0.87; <em>p</em> = 0.004; I<sup>2</sup> = 0%) after 30–45 days and severe crusts at 14–21 days (RR = 0.59; 95% CI 0.38 to 0.91; <em>p</em> = 0.02; I<sup>2</sup> = 0%). Additionally, the persistence of polypoid mucosa was lower in the intervention arm (RR = 0.53; 95% CI 0.43 to 0.65; <em>p</em> &lt; 0.00001; I<sup>2</sup> = 0%) after 14–21 days. In the symptomatic evaluation hypertonic saline group showed an improvement in postoperative symptoms by a VAS Mean Difference (MD) (MD = −5; 95% CI −5.77 to −4.24; <em>p</em> &lt; 0.00001; I<sup>2</sup> = 0%) and a SNOT 20/22 Standard Mean Difference (SMD) (SMD = −1.65; 95% CI −2.7 to −0.61; <em>p</em> = 0.002; I<sup>2</sup> = 93%) reduction from baseline in 30–45 days after the surgery.</div></div><div><h3>Conclusion</h3><div>Hypertonic saline showed a superior improvement in postoperative evaluation by means of nasal crusting, mucosal healing aspect, and nasal inflammatory symptoms compared with isotonic saline irrigation.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101517"},"PeriodicalIF":1.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of hearing impairment on cognitive performance 听力障碍对认知能力的影响。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-11-05 DOI: 10.1016/j.bjorl.2024.101521
Pedro Ivo Machado Pires de Araújo , Pauliana Lamounier e Silva Duarte , Hugo Valter Lisboa Ramos , Claudiney Cândido Costa , Isabela Gomes Maldi , Lucas da Silva Braz , Norma de Oliveira Penido

Objective

This study aims to evaluate the cognitive performance in adults with hearing loss and to identify associations between clinical characteristics of hearing loss and cognitive outcomes.

Methods

In this cross-sectional analytical observational study, adults with hearing loss underwent the Mini-Mental State Examination (MMSE), following the collection of their clinical and audiometric data.

Results

Among 134 evaluated individuals, a majority reported a progressive onset (91.04%) and bilateral nature (87.31%) of hearing loss, with moderate hearing loss being the most common (41.04%). Sensorineural hearing loss was prevalent in 76.12% of cases, with presbycusis identified as a primary etiology in 37.31%. Comorbidities were reported in 61.19% of participants, with 16.42% using benzodiazepines or antidepressants regularly. Symptoms included imbalance (33.58%), vertigo (42.54%), and tinnitus (73.88%). Notably, a sudden onset of hearing loss and imbalance complaints were linked to a higher likelihood of subnormal MMSE performance. Analysis revealed varied cognitive domain performances associated with different clinical characteristics of hearing loss.

Conclusion

Various aspects of hearing loss, such as bilateral and sensorineural types, and the presence of symptoms like tinnitus and vertigo, significantly influence cognitive performance. Specifically, sudden onset hearing loss and imbalance complaints are associated with poorer overall cognitive outcomes in the MMSE. These findings underscore the importance of considering the diverse impacts of hearing loss characteristics on cognitive functions.

Level of evidence

Level 4.
研究目的本研究旨在评估听力损失成年人的认知能力,并确定听力损失的临床特征与认知结果之间的关联:在这项横断面分析观察研究中,成年听力损失患者在收集了临床和听力数据后接受了迷你智力状态检查(MMSE):在 134 名接受评估的人中,大多数人的听力损失是渐进性的(91.04%)和双侧性的(87.31%),其中中度听力损失最为常见(41.04%)。76.12%的病例普遍存在感音神经性听力损失,37.31%的病例的主要病因是老花眼。61.19%的参与者患有合并症,16.42%的参与者经常使用苯二氮卓类药物或抗抑郁药物。症状包括失衡(33.58%)、眩晕(42.54%)和耳鸣(73.88%)。值得注意的是,突然出现听力损失和失衡症状与 MMSE 成绩低于正常水平的可能性较高有关。分析表明,不同的听力损失临床特征会导致不同的认知领域表现:结论:听力损失的各个方面,如双侧听力损失和感音神经性听力损失,以及耳鸣和眩晕等症状的存在,都会对认知能力产生重大影响。具体而言,突发性听力损失和失衡主诉与 MMSE 的整体认知结果较差有关。这些发现强调了考虑听力损失特征对认知功能的不同影响的重要性:证据等级:4级。
{"title":"Impact of hearing impairment on cognitive performance","authors":"Pedro Ivo Machado Pires de Araújo ,&nbsp;Pauliana Lamounier e Silva Duarte ,&nbsp;Hugo Valter Lisboa Ramos ,&nbsp;Claudiney Cândido Costa ,&nbsp;Isabela Gomes Maldi ,&nbsp;Lucas da Silva Braz ,&nbsp;Norma de Oliveira Penido","doi":"10.1016/j.bjorl.2024.101521","DOIUrl":"10.1016/j.bjorl.2024.101521","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate the cognitive performance in adults with hearing loss and to identify associations between clinical characteristics of hearing loss and cognitive outcomes.</div></div><div><h3>Methods</h3><div>In this cross-sectional analytical observational study, adults with hearing loss underwent the Mini-Mental State Examination (MMSE), following the collection of their clinical and audiometric data.</div></div><div><h3>Results</h3><div>Among 134 evaluated individuals, a majority reported a progressive onset (91.04%) and bilateral nature (87.31%) of hearing loss, with moderate hearing loss being the most common (41.04%). Sensorineural hearing loss was prevalent in 76.12% of cases, with presbycusis identified as a primary etiology in 37.31%. Comorbidities were reported in 61.19% of participants, with 16.42% using benzodiazepines or antidepressants regularly. Symptoms included imbalance (33.58%), vertigo (42.54%), and tinnitus (73.88%). Notably, a sudden onset of hearing loss and imbalance complaints were linked to a higher likelihood of subnormal MMSE performance. Analysis revealed varied cognitive domain performances associated with different clinical characteristics of hearing loss.</div></div><div><h3>Conclusion</h3><div>Various aspects of hearing loss, such as bilateral and sensorineural types, and the presence of symptoms like tinnitus and vertigo, significantly influence cognitive performance. Specifically, sudden onset hearing loss and imbalance complaints are associated with poorer overall cognitive outcomes in the MMSE. These findings underscore the importance of considering the diverse impacts of hearing loss characteristics on cognitive functions.</div></div><div><h3>Level of evidence</h3><div>Level 4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 2","pages":"Article 101521"},"PeriodicalIF":1.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perineural invasion and laryngeal squamous cell carcinoma: a systematic review 硬膜外侵犯与喉鳞状细胞癌:系统综述。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.bjorl.2024.101519
Debora Modelli Vianna Ocampo Quintana , Rogerio Aparecido Dedivitis , Luiz Paulo Kowalski

Objectives

Several studies have evaluated the prognostic significance of Perineural Invasion (IPN) in laryngeal cancer; however, the results are non-conclusive. Therefore, we conducted a meta-analysis aiming to identify the prognostic value of IPN in laryngeal cancer.

Methods

A literature review was performed, searching MedLine via PubMed, Scielo, Lilacs, Cochrane and Websco. RevMan 5.4 was used for the statistical analysis.

Results

A total of 19 laryngeal cancer studies were included. The results indicate that IPN in laryngeal cancer shows 2-year survival with RR 0.71 (0.59‒0.86); disease-free survival RR 0.51 (0.14–1.95); and locoregional recurrence RR 1.71 (1.25–2.35).

Conclusion

IPN is a negative prognostic factor in laryngeal cancer.
研究目的有几项研究评估了喉癌神经周围侵犯(IPN)的预后意义,但结果尚无定论。因此,我们进行了一项荟萃分析,旨在确定 IPN 在喉癌中的预后价值:方法:通过PubMed、Scielo、Lilacs、Cochrane和Websco检索MedLine,进行文献综述。统计分析使用 RevMan 5.4:结果:共纳入 19 项喉癌研究。结果显示,IPN在喉癌中的2年生存率为RR 0.71(0.59-0.86);无病生存率为RR 0.51(0.14-1.95);局部复发率为RR 1.71(1.25-2.35):结论:IPN是喉癌的不良预后因素。
{"title":"Perineural invasion and laryngeal squamous cell carcinoma: a systematic review","authors":"Debora Modelli Vianna Ocampo Quintana ,&nbsp;Rogerio Aparecido Dedivitis ,&nbsp;Luiz Paulo Kowalski","doi":"10.1016/j.bjorl.2024.101519","DOIUrl":"10.1016/j.bjorl.2024.101519","url":null,"abstract":"<div><h3>Objectives</h3><div>Several studies have evaluated the prognostic significance of Perineural Invasion (IPN) in laryngeal cancer; however, the results are non-conclusive. Therefore, we conducted a meta-analysis aiming to identify the prognostic value of IPN in laryngeal cancer.</div></div><div><h3>Methods</h3><div>A literature review was performed, searching MedLine via PubMed, Scielo, Lilacs, Cochrane and Websco. RevMan 5.4 was used for the statistical analysis.</div></div><div><h3>Results</h3><div>A total of 19 laryngeal cancer studies were included. The results indicate that IPN in laryngeal cancer shows 2-year survival with RR 0.71 (0.59‒0.86); disease-free survival RR 0.51 (0.14–1.95); and locoregional recurrence RR 1.71 (1.25–2.35).</div></div><div><h3>Conclusion</h3><div>IPN is a negative prognostic factor in laryngeal cancer.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101519"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic-assisted cochlear implant surgery 机器人辅助人工耳蜗植入手术
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-11-01 DOI: 10.1016/j.bjorl.2024.101530
Vagner Antonio Rodrigues Silva, Arthur Menino Castilho
{"title":"Robotic-assisted cochlear implant surgery","authors":"Vagner Antonio Rodrigues Silva,&nbsp;Arthur Menino Castilho","doi":"10.1016/j.bjorl.2024.101530","DOIUrl":"10.1016/j.bjorl.2024.101530","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 6","pages":"Article 101530"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enlarged vestibular aqueduct with bilateral sensorineural hearing loss following cranial trauma: a case report 颅脑外伤后前庭导水管扩大伴双侧感音神经性听力损失:病例报告
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-10-30 DOI: 10.1016/j.bjorl.2024.101518
Alexandre Camilotti Gasperin , Bruna Timm Monteiro , Ellen Paula Schetz Zawierucha , Enrico Guido Oliveira Minniti , Matheus Roberto Schetz Alves , Pedro Henrique Vicari Passos
{"title":"Enlarged vestibular aqueduct with bilateral sensorineural hearing loss following cranial trauma: a case report","authors":"Alexandre Camilotti Gasperin ,&nbsp;Bruna Timm Monteiro ,&nbsp;Ellen Paula Schetz Zawierucha ,&nbsp;Enrico Guido Oliveira Minniti ,&nbsp;Matheus Roberto Schetz Alves ,&nbsp;Pedro Henrique Vicari Passos","doi":"10.1016/j.bjorl.2024.101518","DOIUrl":"10.1016/j.bjorl.2024.101518","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101518"},"PeriodicalIF":1.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-clinical training, technical adjustment and human case experience of transoral robotic surgery using Versius System 使用 Versius 系统进行经口机器人手术的临床前培训、技术调整和人体病例体验。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-10-04 DOI: 10.1016/j.bjorl.2024.101515
Guilherme Reimann Agne , Gustavo Nunes Bento , Marcelo Belli , Gustavo Becker Pereira , Renan Bezerra Lira , Leandro Luongo Matos , Luiz Paulo Kowalski

Objective

This study describes the training experience with the Versius Robotic System (CMR Surgical) for Transoral Robotic Surgery (TORS), the setup of the robot and its applicability in a human case.

Methods

A model mannequin with anatomical characteristics simulating the TORS working space was used for training purposes. Optimal docking, positioning of robotic arms and placement of instruments were defined using the mannequin. A human patient was selected based on the inclusion criteria, and a standardized protocol for robotic techniques was developed. The surgical procedure was conducted in accordance with ethical guidelines.

Results

The synthetic polymer mannequin mimicking human tissues and anatomy was used to define the robot set up for TORS. The patient was indicated for bilateral tonsillectomy due to recurrent episodes of tonsillitis. Bipolar Maryland and monopolar scissors were used. The procedure was uneventful. The patient remained hospitalized for 1 day and returned to work activities within 6-days, with no complications.

Conclusion

The specialized mannequin proved to be effective in the simulation, training proposal and set up standardization. Furthermore, the Versius robot was found to be safe and achieved excellent results during surgery. Despite being very promising, the Versius system is still in its developmental phase and requires larger-scale samples for a more comprehensive evaluation.

Level of evidence

4.
本研究介绍了使用 Versius 机器人系统(CMR 外科公司)进行经口机器人手术(TORS)的培训经验、机器人的设置及其在人体病例中的适用性。使用人体模型确定了最佳对接、机械臂定位和器械放置位置。根据纳入标准选择了一名人类患者,并制定了机器人技术的标准化方案。手术过程符合伦理准则。结果模拟人体组织和解剖结构的合成聚合物人体模型被用于确定 TORS 的机器人设置。患者因扁桃体炎反复发作而需要进行双侧扁桃体切除术。使用了双极马里兰和单极剪刀。手术过程顺利。患者住院1天,6天内恢复工作,无并发症。此外,Versius 机器人在手术过程中安全可靠,效果极佳。尽管Versius系统前景广阔,但仍处于开发阶段,需要更大规模的样本才能进行更全面的评估。
{"title":"Pre-clinical training, technical adjustment and human case experience of transoral robotic surgery using Versius System","authors":"Guilherme Reimann Agne ,&nbsp;Gustavo Nunes Bento ,&nbsp;Marcelo Belli ,&nbsp;Gustavo Becker Pereira ,&nbsp;Renan Bezerra Lira ,&nbsp;Leandro Luongo Matos ,&nbsp;Luiz Paulo Kowalski","doi":"10.1016/j.bjorl.2024.101515","DOIUrl":"10.1016/j.bjorl.2024.101515","url":null,"abstract":"<div><h3>Objective</h3><div>This study describes the training experience with the Versius Robotic System (CMR Surgical) for Transoral Robotic Surgery (TORS), the setup of the robot and its applicability in a human case.</div></div><div><h3>Methods</h3><div>A model mannequin with anatomical characteristics simulating the TORS working space was used for training purposes. Optimal docking, positioning of robotic arms and placement of instruments were defined using the mannequin. A human patient was selected based on the inclusion criteria, and a standardized protocol for robotic techniques was developed. The surgical procedure was conducted in accordance with ethical guidelines.</div></div><div><h3>Results</h3><div>The synthetic polymer mannequin mimicking human tissues and anatomy was used to define the robot set up for TORS. The patient was indicated for bilateral tonsillectomy due to recurrent episodes of tonsillitis. Bipolar Maryland and monopolar scissors were used. The procedure was uneventful. The patient remained hospitalized for 1 day and returned to work activities within 6-days, with no complications.</div></div><div><h3>Conclusion</h3><div>The specialized mannequin proved to be effective in the simulation, training proposal and set up standardization. Furthermore, the Versius robot was found to be safe and achieved excellent results during surgery. Despite being very promising, the Versius system is still in its developmental phase and requires larger-scale samples for a more comprehensive evaluation.</div></div><div><h3>Level of evidence</h3><div>4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101515"},"PeriodicalIF":1.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative adjuvant chemoradiotherapy versus postoperative adjuvant radiotherapy for head and neck squamous cell carcinoma with adverse pathology: a systematic review and meta-analysis 头颈部鳞状细胞癌术后辅助化疗与术后辅助放疗的不良病理结果:系统综述与荟萃分析
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-10-04 DOI: 10.1016/j.bjorl.2024.101516
Gabriela Garcia Korczaguin , Gilberto Vaz Teixeira , Ashok Shaha

Objectives

Postoperative chemoradiotherapy has arisen as an adjuvant option for head and neck cancers, but its superiority to radiotherapy alone in patients with adverse pathologic factors is not yet well defined. We aimed to perform an updated meta-analysis comparing outcomes in head and neck cancer patients with adverse pathologic factors who underwent postoperative chemoradiotherapy and radiotherapy alone.

Methods

We systematically searched PubMed, Scopus and the Cochrane Central Register of Controlled Trials for Randomised Controlled Trials (RCTs) in patients submitted to postoperative adjuvant therapy with radiotherapy alone or chemoradiotherapy.

Results

We included 8 studies with a total of 2376 patients, of whom 1183 (49.8%) underwent postoperative chemoradiotherapy. In pooled analysis, overall survival (HR = 0.86; 95% CI 0.76‒0.98; p = 0.64; I2 = 0%) and disease-free survival (HR = 0.85; 95% CI 0.75‒0.96; p = 0.64; I2 = 0%) were shown to be superior in patients undergoing combined therapy. Chemoradiotherapy was also associated with significantly lower locoregional recurrence. However, there was no significant difference in distant metastasis occurrence between both groups. In an analysis of the extracapsular extension subgroup, the overall survival (OR = 3.12; 95% CI 1.76–5.51; p = 0.78; I2 = 0%), disease-free survival (OR = 3.44; 95% CI 2.00‒5.91; p = 0.68; I2 = 0%), and locoregional control (OR = 1.86; 95% CI 1.16‒2.99; p = 0.98; I2 = 0%) were better in the postoperative adjuvant chemoradiotherapy branch over radiotherapy alone.

Conclusion

The results of our meta-analysis suggest that postoperative adjuvant chemoradiotherapy in patients with head and neck cancer with adverse pathologic factors favors a superior survival and a better locoregional control compared to postoperative radiotherapy alone, despite not affecting the ocurrence of distant metastasis.
目的 术后化放疗已成为头颈部癌症的一种辅助治疗方法,但在有不良病理因素的患者中,化放疗优于单纯放疗的情况尚未明确。我们旨在进行一项最新的荟萃分析,比较有不良病理因素的头颈部癌症患者术后化放疗和单纯放疗的疗效。方法我们系统检索了PubMed、Scopus和Cochrane对照试验中央注册中心的随机对照试验(RCTs),研究对象为接受术后辅助治疗、单纯放疗或化疗的患者。结果我们纳入了8项研究,共2376名患者,其中1183人(49.8%)接受了术后化疗。汇总分析表明,接受联合治疗的患者总生存期(HR = 0.86;95% CI 0.76-0.98;P = 0.64;I2 = 0%)和无病生存期(HR = 0.85;95% CI 0.75-0.96;P = 0.64;I2 = 0%)更优。化放疗也与显著降低局部复发率有关。不过,两组患者的远处转移发生率没有明显差异。在囊外扩展亚组的分析中,术后辅助化放疗组的总生存率(OR = 3.12;95% CI 1.76-5.51;P = 0.78;I2 = 0%)、无病生存率(OR = 3.44;95% CI 2.00-5.91;P = 0.68;I2 = 0%)和局部控制率(OR = 1.86;95% CI 1.16-2.99;P = 0.98;I2 = 0%)均优于单纯放疗组。结论我们的荟萃分析结果表明,与单纯术后放疗相比,对有不良病理因素的头颈部癌症患者进行术后辅助化放疗有利于提高患者的生存率和局部控制率,尽管这不会影响远处转移的发生。
{"title":"Postoperative adjuvant chemoradiotherapy versus postoperative adjuvant radiotherapy for head and neck squamous cell carcinoma with adverse pathology: a systematic review and meta-analysis","authors":"Gabriela Garcia Korczaguin ,&nbsp;Gilberto Vaz Teixeira ,&nbsp;Ashok Shaha","doi":"10.1016/j.bjorl.2024.101516","DOIUrl":"10.1016/j.bjorl.2024.101516","url":null,"abstract":"<div><h3>Objectives</h3><div>Postoperative chemoradiotherapy has arisen as an adjuvant option for head and neck cancers, but its superiority to radiotherapy alone in patients with adverse pathologic factors is not yet well defined. We aimed to perform an updated meta-analysis comparing outcomes in head and neck cancer patients with adverse pathologic factors who underwent postoperative chemoradiotherapy and radiotherapy alone.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Scopus and the Cochrane Central Register of Controlled Trials for Randomised Controlled Trials (RCTs) in patients submitted to postoperative adjuvant therapy with radiotherapy alone or chemoradiotherapy.</div></div><div><h3>Results</h3><div>We included 8 studies with a total of 2376 patients, of whom 1183 (49.8%) underwent postoperative chemoradiotherapy. In pooled analysis, overall survival (HR<!--> <!-->=<!--> <!-->0.86; 95% CI 0.76‒0.98; <em>p</em> <!-->=<!--> <!-->0.64; I<sup>2</sup> <!-->=<!--> <!-->0%) and disease-free survival (HR<!--> <!-->=<!--> <!-->0.85; 95% CI 0.75‒0.96; <em>p</em> <!-->=<!--> <!-->0.64; I<sup>2</sup> <!-->=<!--> <!-->0%) were shown to be superior in patients undergoing combined therapy. Chemoradiotherapy was also associated with significantly lower locoregional recurrence. However, there was no significant difference in distant metastasis occurrence between both groups. In an analysis of the extracapsular extension subgroup, the overall survival (OR<!--> <!-->=<!--> <!-->3.12; 95% CI 1.76–5.51; <em>p</em> <!-->=<!--> <!-->0.78; I<sup>2</sup> <!-->=<!--> <!-->0%), disease-free survival (OR<!--> <!-->=<!--> <!-->3.44; 95% CI 2.00‒5.91; <em>p</em> <!-->=<!--> <!-->0.68; I<sup>2</sup> <!-->=<!--> <!-->0%), and locoregional control (OR<!--> <!-->=<!--> <!-->1.86; 95% CI 1.16‒2.99; <em>p</em> <!-->=<!--> <!-->0.98; I<sup>2</sup> <!-->=<!--> <!-->0%) were better in the postoperative adjuvant chemoradiotherapy branch over radiotherapy alone.</div></div><div><h3>Conclusion</h3><div>The results of our meta-analysis suggest that postoperative adjuvant chemoradiotherapy in patients with head and neck cancer with adverse pathologic factors favors a superior survival and a better locoregional control compared to postoperative radiotherapy alone, despite not affecting the ocurrence of distant metastasis.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101516"},"PeriodicalIF":1.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brazilian Society of Otology task force – single sided deafness – recommendations based on strength of evidence 巴西耳科学会特别工作组--单侧耳聋--基于证据强度的建议。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-09-24 DOI: 10.1016/j.bjorl.2024.101514
Robinson Koji Tsuji , Rogério Hamerschmidt , Joel Lavinsky , Felippe Felix , Vagner Antonio Rodrigues Silva

Objective

To make evidence-based recommendations for the treatment of Single-Sided Deafness (SSD) in children and adults.

Methods

Task force members were instructed on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on SSD were eligible for inclusion. The American College of Physicians’ guideline grading system and the American Thyroid Association’s guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions.

Results

The topics were divided into 3 parts: (1) Impact of SSD in children; (2) Impact of SSD in adults; and (3) SSD in patients with temporal bone tumors.

Conclusions

Decision-making for patients with SSD is complex and multifactorial. The lack of consensus on the quality of outcomes and on which measurement tools to use hinders a proper comparison of different treatment options. Contralateral routing of signal hearing aids and bone conduction devices can alleviate the head shadow effect and improve sound awareness and signal-to-noise ratio in the affected ear. However, they cannot restore binaural hearing. Cochlear implants can restore binaural hearing, producing significant improvements in speech perception, spatial localization of sound, tinnitus control, and overall quality of life. However, cochlear implantation is not recommended in cases of cochlear nerve deficiency, a relatively common cause of congenital SSD.
目的:为儿童和成人单侧耳聋(SSD)的治疗提供循证建议:为儿童和成人单侧耳聋(SSD)的治疗提供循证建议:向工作组成员传授知识综合方法,包括电子数据库搜索、审查和选择相关引文,以及对所选研究进行批判性评估。以英语或葡萄牙语撰写的有关 SSD 的文章均符合纳入条件。美国内科医师学会的指南分级系统和美国甲状腺协会的指南标准被用于对证据和治疗干预建议进行批判性评估:主题分为三部分:(1) SSD 对儿童的影响;(2) SSD 对成人的影响;(3) SSD 对颞骨肿瘤患者的影响:对 SSD 患者的决策是复杂和多因素的。结论:SSD 患者的决策是复杂和多因素的,在结果质量和使用何种测量工具方面缺乏共识,这阻碍了对不同治疗方案进行适当的比较。信号助听器和骨传导设备的对侧路由可以减轻头影效应,改善患耳的声音意识和信噪比。但是,它们无法恢复双耳听力。人工耳蜗可以恢复双耳听力,显著改善言语感知、声音空间定位、耳鸣控制和整体生活质量。但是,对于耳蜗神经缺失的病例,我们不建议进行人工耳蜗植入,因为这是先天性 SSD 的一个相对常见的原因。
{"title":"Brazilian Society of Otology task force – single sided deafness – recommendations based on strength of evidence","authors":"Robinson Koji Tsuji ,&nbsp;Rogério Hamerschmidt ,&nbsp;Joel Lavinsky ,&nbsp;Felippe Felix ,&nbsp;Vagner Antonio Rodrigues Silva","doi":"10.1016/j.bjorl.2024.101514","DOIUrl":"10.1016/j.bjorl.2024.101514","url":null,"abstract":"<div><h3>Objective</h3><div>To make evidence-based recommendations for the treatment of Single-Sided Deafness (SSD) in children and adults.</div></div><div><h3>Methods</h3><div>Task force members were instructed on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on SSD were eligible for inclusion. The American College of Physicians’ guideline grading system and the American Thyroid Association’s guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions.</div></div><div><h3>Results</h3><div>The topics were divided into 3 parts: (1) Impact of SSD in children; (2) Impact of SSD in adults; and (3) SSD in patients with temporal bone tumors.</div></div><div><h3>Conclusions</h3><div>Decision-making for patients with SSD is complex and multifactorial. The lack of consensus on the quality of outcomes and on which measurement tools to use hinders a proper comparison of different treatment options. Contralateral routing of signal hearing aids and bone conduction devices can alleviate the head shadow effect and improve sound awareness and signal-to-noise ratio in the affected ear. However, they cannot restore binaural hearing. Cochlear implants can restore binaural hearing, producing significant improvements in speech perception, spatial localization of sound, tinnitus control, and overall quality of life. However, cochlear implantation is not recommended in cases of cochlear nerve deficiency, a relatively common cause of congenital SSD.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101514"},"PeriodicalIF":1.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between vestibular response to caloric stimulation and cochlear function in Ménière's disease 梅尼埃病患者前庭对热量刺激的反应与耳蜗功能之间的相关性。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-09-19 DOI: 10.1016/j.bjorl.2024.101513
Leticia da Rosa Heinen , Marcelo Assis Moro da Rocha Filho , Artur Zanelatto Santos , Amanda Calage Pinto , Samuel Afonso de Freitas Toledo , Luiz Lavinsky , Joel Lavinsky

Objective

To analyze the correlation between caloric testing response patterns with respect to cochlear impairment in individuals with unilateral Ménière's disease.

Methods

In this observational cross-sectional study, the factor under study was Ménière's disease and the outcome was cochleovestibular function, evaluated through caloric stimulation using videonystagmography and four-frequency averages in pure tone audiometry.

Results

A total of 187 patients (equal sex distribution) who met the inclusion criteria were included. In impairment analysis of the affected ear, 17 patients had only vestibular impairment, 56 had only cochlear impairment, and 114 had cochleovestibular impairment. The distribution of Ménière's disease stages according to four-frequency average was grade I: 23.53%, grade II: 16.04%, grade III: 42.25%, and grade IV: 18.18%. There was a significant association (p < 0.001) between the affected ear and labyrinthine preponderance. The Spearman correlation between four-frequency average and labyrinth preponderance (r = 0.326) indicated a moderate correlation, considering p < 0.01.

Conclusion

Our results show that the greater the cochlear damage due to Ménière's disease, the more impaired the vestibular function in the affected ear.

Level of evidence

Level 2 - Individual cross-sectional studies with consistently applied reference standard and blinding
目的:分析单侧梅尼埃病患者热量测试反应模式与耳蜗损伤之间的相关性:分析单侧梅尼埃病患者热量测试反应模式与耳蜗损伤之间的相关性:在这项观察性横断面研究中,研究因素是梅尼埃病,研究结果是耳蜗前庭功能,通过使用视频震颤成像的热量刺激和纯音测听的四频平均值进行评估:共纳入了 187 名符合纳入标准的患者(男女比例相同)。在对患耳进行损伤分析时,17 名患者只有前庭损伤,56 名患者只有耳蜗损伤,114 名患者有耳蜗前庭损伤。根据四频平均值,梅尼埃病的分期分布为Ⅰ级:23.53%,Ⅱ级:16.04%,Ⅲ级:42.25%,Ⅳ级:18.18%。两者之间存在明显的关联(P我们的研究结果表明,梅尼埃病导致的耳蜗损伤越严重,患耳的前庭功能受损越严重:证据等级:2 级 - 单项横断面研究,采用一致的参考标准和盲法。
{"title":"Correlation between vestibular response to caloric stimulation and cochlear function in Ménière's disease","authors":"Leticia da Rosa Heinen ,&nbsp;Marcelo Assis Moro da Rocha Filho ,&nbsp;Artur Zanelatto Santos ,&nbsp;Amanda Calage Pinto ,&nbsp;Samuel Afonso de Freitas Toledo ,&nbsp;Luiz Lavinsky ,&nbsp;Joel Lavinsky","doi":"10.1016/j.bjorl.2024.101513","DOIUrl":"10.1016/j.bjorl.2024.101513","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the correlation between caloric testing response patterns with respect to cochlear impairment in individuals with unilateral Ménière's disease.</div></div><div><h3>Methods</h3><div>In this observational cross-sectional study, the factor under study was Ménière's disease and the outcome was cochleovestibular function, evaluated through caloric stimulation using videonystagmography and four-frequency averages in pure tone audiometry.</div></div><div><h3>Results</h3><div>A total of 187 patients (equal sex distribution) who met the inclusion criteria were included. In impairment analysis of the affected ear, 17 patients had only vestibular impairment, 56 had only cochlear impairment, and 114 had cochleovestibular impairment. The distribution of Ménière's disease stages according to four-frequency average was grade I: 23.53%, grade II: 16.04%, grade III: 42.25%, and grade IV: 18.18%. There was a significant association (<em>p</em> &lt; 0.001) between the affected ear and labyrinthine preponderance. The Spearman correlation between four-frequency average and labyrinth preponderance (<em>r</em> = 0.326) indicated a moderate correlation, considering <em>p</em> &lt; 0.01.</div></div><div><h3>Conclusion</h3><div>Our results show that the greater the cochlear damage due to Ménière's disease, the more impaired the vestibular function in the affected ear.</div></div><div><h3>Level of evidence</h3><div>Level 2 - Individual cross-sectional studies with consistently applied reference standard and blinding</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101513"},"PeriodicalIF":1.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brazilian Society of Otology task force – cochlear implant ‒ recommendations based on strength of evidence 巴西耳科学会特别工作组--人工耳蜗植入--基于证据力度的建议。
IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY Pub Date : 2024-09-16 DOI: 10.1016/j.bjorl.2024.101512
Robinson Koji Tsuji , Rogério Hamerschmidt , Joel Lavinsky , Felippe Felix , Vagner Antonio Rodrigues Silva

Objective

To make evidence-based recommendations for the indications and complications of Cochlear Implant (CI) surgery in adults and children.

Methods

Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on cochlear implantation were eligible for inclusion. The American College of Physicians’ guideline grading system and the American Thyroid Association’s guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions.

Results

The topics were divided into 2 parts: (1) Evaluation of candidate patients and indications for CI surgery; (2) CI surgery – techniques and complications.

Conclusions

CI is a safe device for auditory rehabilitation of patients with severe-to-profound hearing loss. In recent years, indications for unilateral hearing loss and vestibular schwannoma have been expanded, with encouraging results. However, for a successful surgery, commitment of family members and patients in the hearing rehabilitation process is essential.
目的:就成人和儿童人工耳蜗手术的适应症和并发症提出循证建议:针对成人和儿童人工耳蜗手术的适应症和并发症提出循证建议:向工作组成员传授知识综合方法,包括电子数据库搜索、审查和选择相关引文,以及对所选研究进行批判性评估。以英语或葡萄牙语撰写的有关人工耳蜗植入的文章均符合纳入条件。采用美国内科医师学会的指南分级系统和美国甲状腺协会的指南标准对证据进行严格评估,并提出治疗干预建议:主题分为两部分:(1)候选患者的评估和CI手术的适应症;(2)CI手术--技术和并发症:CI 是一种安全的听力康复设备,适用于重度至永久性听力损失患者。近年来,单侧听力损失和前庭分裂瘤的适应症不断扩大,并取得了令人鼓舞的成果。然而,要想手术成功,家属和患者在听力康复过程中的承诺至关重要。
{"title":"Brazilian Society of Otology task force – cochlear implant ‒ recommendations based on strength of evidence","authors":"Robinson Koji Tsuji ,&nbsp;Rogério Hamerschmidt ,&nbsp;Joel Lavinsky ,&nbsp;Felippe Felix ,&nbsp;Vagner Antonio Rodrigues Silva","doi":"10.1016/j.bjorl.2024.101512","DOIUrl":"10.1016/j.bjorl.2024.101512","url":null,"abstract":"<div><h3>Objective</h3><div>To make evidence-based recommendations for the indications and complications of Cochlear Implant (CI) surgery in adults and children.</div></div><div><h3>Methods</h3><div>Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on cochlear implantation were eligible for inclusion. The American College of Physicians’ guideline grading system and the American Thyroid Association’s guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions.</div></div><div><h3>Results</h3><div>The topics were divided into 2 parts: (1) Evaluation of candidate patients and indications for CI surgery; (2) CI surgery – techniques and complications.</div></div><div><h3>Conclusions</h3><div>CI is a safe device for auditory rehabilitation of patients with severe-to-profound hearing loss. In recent years, indications for unilateral hearing loss and vestibular schwannoma have been expanded, with encouraging results. However, for a successful surgery, commitment of family members and patients in the hearing rehabilitation process is essential.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101512"},"PeriodicalIF":1.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Brazilian Journal of Otorhinolaryngology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1