Brazilian Journal of Otorhinolaryngology最新文献_第3页

Vocal quality impact of thyroidectomized patients underwent inferior laryngeal nerves monitoring 甲状腺切除术后喉下神经监测对声带质量的影响

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-11-26 DOI: 10.1016/j.bjorl.2025.101740

Roberto Massao Takimoto , Márcio Abrahão , Felipe Gregolin Brandão , Lara Hossepian Hojaij , Onivaldo Cervantes

Objective

The present study’s goal was to estimate the inferior laryngeal nerves monitoring impact on patient’s vocal quality after thyroidectomy in head and neck surgery training program.

Methods

Eighty-five patients were evaluated, mean age 48,19 yrs., with no thyroid hormone dysfunctions. They were randomly distributed into two groups. Forty patients were operated on without nerve monitor (Group A) and other 45 with nerve monitor (Group B). The groups were controlled by gender, age, tobacco use, thyroid volume, surgery extent, post-op hypoparathyroidism, malignancy and laryngeal trauma. The patients went through perceptive evaluation and acoustic vocal analysis, before and after surgery (1st and 4th week). The same group of head and neck resident surgeons operated on all patients.

Results

In perceptive evaluation, only breathiness (4th week), showed significant difference between the groups (25% in Group A vs. 6.7% in Group B, p = 0.041). However, when the patients were compared with themselves, evaluating the status before versus after surgery, none of the parameters, not even breathiness, showed any significant difference. In vocal acoustic analysis, no significant difference was observed. Fundamental frequency (Hz) in women was 202.62 (before surgery), 198.19 (1st-week) and 191.90 (4th-week) in Group A, and 193.48 (before surgery), 190.63 (1st week) and 186.81 (4th week) in Group B.

Conclusion

At the present study, there was no impact, neither improvement nor worsening, in vocal quality of patients submitted to thyroidectomies with inferior laryngeal nerves monitoring.

Level of evidence

Level 1.

目的探讨头颈部手术训练中喉下神经监测对甲状腺切除术后患者嗓音质量的影响。方法对85例患者进行评价，平均年龄48岁，19岁。，没有甲状腺激素功能障碍。他们被随机分为两组。A组无神经监护40例，B组有神经监护45例。各组按性别、年龄、吸烟情况、甲状腺体积、手术程度、术后甲状旁腺功能减退、恶性肿瘤及喉外伤进行控制。术前、术后（第1周、第4周）对患者进行感知评价和声学声乐分析。所有患者均由同一组头颈部住院医师进行手术。结果在知觉评价中，仅呼吸（第4周）两组间差异有统计学意义（A组为25%，B组为6.7%,p = 0.041）。然而，当患者与自己进行比较，评估手术前后的状态时，没有任何参数，甚至呼吸，显示出任何显着差异。在声带声学分析中，没有观察到显著差异。A组女性基本频率（Hz）为202.62（术前）、198.19（第1周）、191.90（第4周），b组为193.48（术前）、190.63（第1周）、186.81（第4周）。结论本研究对甲状腺切除术患者喉下神经监测对声带质量无影响，无改善，无恶化。证据等级：1级。

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引用次数: 0

Tomographic comparison of the cochlea, oval window, round window and facial nerve between adults and children and their influence on cochlear implant surgery 成人与儿童耳蜗、卵形窗、圆形窗和面神经的断层扫描比较及其对人工耳蜗手术的影响

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-10-24 DOI: 10.1016/j.bjorl.2025.101731

Rogerio Hamerschmidt , Mohamad Feras Al-lahham , Bettina Carvalho , Mayara Risnei Watanabe , Rogério de Azevedo Hamerschmidt , Isadora Mansur Castro

Objective

Is to compare two tomographic measurements that can be used to predict the visibility of the round window: the angle formed by the junction of the line that goes from the round window Membrane Center Point (MJR) to the Facial Nerve surface (FN) with the Coronal Plane (CP) traced over this surface (RWM-FN-CP Angle) and the vertical distance between the midpoint of the RWM and this Coronal Plane (RWM-CP Vertical Distance); in adults and children, in order to verify if there are significant differences between the groups, which would justify the greater surgical difficulty caused by the lower visibility of the RW in children.

Methods

In this retrospective study, the RWM-FN-CP angle and the RWM-CP vertical distance were measured in Computerized Tomography Scans (CT) of patients who underwent CI surgeries.

Results

32 individuals who underwent CT in the period 2015–2018, 16 adults aged 27–73 years, and 16 children, with a mean age of 3.4 (±2.7) years were evaluated. The mean of the RWM-FN-CP angle in children was significantly lower, than the mean in adults. The mean RWM-CP vertical distance in children was significantly lower than the mean in adults (p = 0.0001).

Conclusion

In children, the RWM-FN-CP angle is more acute, and the measured MJR-PC vertical distance is smaller when compared to adults. The anatomical differences observed in the tomographies justify the lower visibility of the RW during the surgical act of cochlear implantation in children.

Level of evidence

3.

目的比较两种可用于预测圆形窗口可见性的层析测量方法：圆形窗口膜中心点（MJR）与面神经表面（FN）的连线与该表面上的冠状面（CP）的连接处形成的角度（RWM-FN-CP角）和RWM中点与该冠状面之间的垂直距离（RWM-CP垂直距离）；在成人和儿童中，为了验证两组之间是否存在显著差异，这将证明儿童RW能见度较低导致手术难度较大。方法回顾性研究行CI手术患者的RWM-FN-CP角和RWM-CP垂直距离。结果2015-2018年接受CT治疗的32例患者，其中成人16例，年龄27-73岁，儿童16例，平均年龄3.4（±2.7）岁。儿童RWM-FN-CP角的平均值明显低于成人。儿童RWM-CP垂直距离均值显著低于成人（p = 0.0001）。结论与成人相比，儿童RWM-FN-CP角度更尖锐，测得MJR-PC垂直距离更小。在断层扫描中观察到的解剖差异证明了在儿童人工耳蜗植入手术过程中RW的能见度较低。证据水平3。

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引用次数: 0

Causal role of immune cells in allergic rhinitis: A bidirectional Mendelian randomization study 免疫细胞在变应性鼻炎中的因果作用：双向孟德尔随机研究

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-10-24 DOI: 10.1016/j.bjorl.2025.101726

Yuhan Tan , Xiaoyan Hu , Jing Zhang , Shuoyu Wan , Liang Jiang

Objective

Previous observational studies have indicated an association between various immune cells and allergic rhinitis; however, the causal relationship remains uncertain. This study seeks to further investigate the causal link between immune cells and allergic rhinitis through bidirectional two-sample Mendelian randomization analysis.

Methods

Allergic rhinitis related data were obtained from the MRC-IEU database, while data for 731 immune cells were sourced from the GWAS catalog. The causal association between immune cells and allergic rhinitis was assessed using inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode methods. Stability and reliability of the findings were evaluated through Cochran's Q test, MR-Egger intercept p-value, and leave-one-out analysis.

Results

Primarily based on IVW methods, 38 distinct immunocyte phenotypes were identified as potentially influencing allergic rhinitis (p < 0.05), while allergic rhinitis was found to potentially impact 20 different immunocyte phenotypes (p < 0.05). The results for heterogeneity, horizontal pleiotropy, and sensitivity analyses demonstrated stability.

Conclusion

This study establishes a strong genetic correlation between immune cells and allergic rhinitis, enhances current knowledge regarding the role of immune cells in AR, and offers potential targets for the development of novel immune-based therapeutic strategies.

Level of evidence

Level 5.

目的以往的观察性研究表明，多种免疫细胞与变应性鼻炎之间存在关联；然而，因果关系仍然不确定。本研究旨在通过双向双样本孟德尔随机分析进一步探讨免疫细胞与变应性鼻炎之间的因果关系。方法变应性鼻炎相关数据来源于MRC-IEU数据库，731个免疫细胞数据来源于GWAS目录。免疫细胞与变应性鼻炎之间的因果关系采用方差反加权、MR-Egger、加权中位数、简单模式和加权模式方法进行评估。通过Cochran’s Q检验、MR-Egger截距p值和留一分析来评估研究结果的稳定性和可靠性。结果主要基于IVW方法，鉴定出38种不同的免疫细胞表型可能影响变应性鼻炎（p < 0.05），而变应性鼻炎可能影响20种不同的免疫细胞表型（p < 0.05）。异质性、水平多效性和敏感性分析的结果显示了稳定性。结论本研究建立了免疫细胞与变应性鼻炎之间强烈的遗传相关性，增强了对免疫细胞在变应性鼻炎中的作用的现有认识，并为开发新的基于免疫的治疗策略提供了潜在的靶点。证据等级：5级。

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引用次数: 0

Effects of inner ear abnormalities on middle ear mechanics: Findings from adults with MD and LVAS 内耳异常对中耳力学的影响：来自MD和LVAS成人的发现

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-09-27 DOI: 10.1016/j.bjorl.2025.101673

Wen Jiang , Yi Mu , Huan Lin , Chanfeng Shen , Huiying Zhang , Fei Zhao , Yuehua Qiao , Xuanyi Li , Wen Liu

Objective

To evaluate the clinical significance of WAI as a predictive marker for MD and LVAS among adults.

Methods

Participants included 110 ears with MD, 18 ears with LVAS, and 92 normal ears (control group) recruited from clinical audiology settings. The outcome measures included Wideband Energy Absorbance (WBA), Resonance Frequency (RF), admittance Magnitude (YM), and phase Angle (YA). Propensity Score Matching (PSM) was conducted to treat the group imbalance.

Results

Compared with the control group, The MD group exhibited significantly lower WBA between 1587 and 4000 Hz (p < 0.05), while the LVAS group showed lower WBA between 1000 and 2520 Hz (p < 0.05). The MD and LVAS groups had lower RF (p < 0.05), while they had higher YM at low frequencies (226 and 678 Hz for MD, and 1000 Hz for LVAS, p < 0.05).

Conclusions

This study showed that LVAS has a lower WBA at middle frequencies, whereas MD has a lower WBA at middle and high frequencies. These findings suggest that WAI may serve as a predictive marker for MD and LVAS. However, further studies are needed to explore its diagnostic utility in Third Mobile Window Abnormalities (TMWA).

Level of evidence

IV: Retrospective cohort study.

目的探讨WAI作为成人MD和LVAS预测指标的临床意义。方法从临床听力学机构招募110只MD耳、18只LVAS耳和92只正常耳（对照组）。结果测量包括宽带能量吸光度（WBA）、共振频率（RF）、导纳幅度（YM）和相位角（YA）。采用倾向得分匹配（PSM）来处理群体失衡。结果与对照组相比，MD组在1587 ~ 4000 Hz范围内WBA显著降低（p < 0.05）， LVAS组在1000 ~ 2520 Hz范围内WBA显著降低（p < 0.05）。MD组和LVAS组RF较低（p < 0.05），而低频YM较高（MD组为226和678 Hz， LVAS组为1000 Hz， p < 0.05）。结论LVAS中频WBA较低，而MD中高频WBA较低。这些发现提示WAI可作为MD和LVAS的预测标志物。然而，需要进一步的研究来探索其在第三移动窗异常（TMWA）中的诊断价值。证据水平iv：回顾性队列研究。

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引用次数: 0

Expectations Questionnaire for Adults with Cochlear Implants (EQA-CI): Translation, adaptation and cross-cultural validation to Brazilian Portuguese 人工耳蜗植入成人期望问卷（EQA-CI）：巴西葡萄牙语的翻译、改编和跨文化验证

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-09-26 DOI: 10.1016/j.bjorl.2025.101717

Ingrid Barros Da Silva Santana , Fernanda Ferreira Caldas , Carolina Costa Cardoso , Francisco Wallison Lucena da Silva , Rayssa Pacheco Brito Dourado , Fayez Bahmad Jr

Objective

To translate, culturally adapt and validate the Cuestionário de Expectativas (CEA) for the Brazilian context, with focus on assessing the expectations of patients during pre-surgical stage.

Methods

An analytical and descriptive study was carried out, including translation, back-translation, adaptation and validation of the CEA. The process involved 119 participants who answered the questionnaire, allowing the analysis of understanding of the items using the Content Validity Index (CVI) and Exploratory Factor Analysis (EFA). Reliability was assessed with Cronbach's Alpha, McDonald's Omega and Composite Reliability coefficients, using Item Response Theory (IRT).

Results

The questionnaire had a total CVI of 0.974, indicating good comprehension by the participants, as well as high values for three internal consistency coefficients (⍺ = 0.828; ω = 0.854; CC = 0.900). The instrument showed great consistency indices and validity measures to be applied on a large scale.

Conclusion

The validity and reliability of the instrument were confirmed. Therefore, the instrument was translated, adapted and validated for Brazilian Portuguese.

Levels of evidence

Step 2.

目的翻译、文化适应和验证巴西情况下的Cuestionário de Expectativas (CEA)，重点评估术前患者的期望。方法对CEA进行翻译、反译、改编和验证等分析性和描述性研究。该过程涉及119名回答问卷的参与者，允许使用内容效度指数（CVI）和探索性因素分析（EFA）来分析对项目的理解。信度评估采用Cronbach's Alpha、McDonald's Omega和复合信度系数，采用项目反应理论（IRT）。结果问卷总CVI为0.974，表明被试理解程度较好，三个内部一致性系数（ω = 0.854, CC = 0.900）均较高。该仪器具有较好的一致性指标和有效性指标，适合大规模应用。结论证实了该仪器的有效性和可靠性。因此，该工具被翻译，改编和验证为巴西葡萄牙语。2.证据级别

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引用次数: 0

Otoprotective effect of the use of antioxidants on noise exposure in experimental studies with rodents – A systematic review with meta-analysis 在啮齿类动物的实验研究中，抗氧化剂对噪声暴露的耳保护作用-一项系统综述和荟萃分析

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-09-26 DOI: 10.1016/j.bjorl.2025.101696

Gabriela Guenther Ribeiro Novanta , Ana Carolina Odorizzi Zica , Maria Luiza Queiroz Sampaio , Camila de Castro Corrêa , Lucieny Silva Martins Serra , Andre Luiz Lopes Sampaio

Objective

To determine the occurrence of otoprotective effect of the use of antioxidants on noise exposure in experimental models with rodents through a systematic review.

Methods

An electronic search was conducted in EMBASE, LILACS, PubMed/Medline, Scopus, Web of Science databases, and in the grey literature of articles published up to June 2022. In the PICO strategy, the studied population consisted of rodent animals exposed to high levels of sound pressure, the intervention consisted of the use of antioxidants, the comparison with the concomitant use of placebo and the results of audiological tests such as Evoked Otoacoustic Emissions and Brainstem Auditory Evoked Potential and the results of histological and immunohistochemical evaluations were collected as outcomes. The analysis of the numerical data was performed according to the Review Manager (Cochrane), using the mean difference as a measure of effect.

Results

35 studies were included in the qualitative synthesis and 27 in the quantitative synthesis. The analysis carried out by CAMARADES indicates that most of the included studies demonstrate methodological quality, and the SYRCLE RoB risk of bias assessment protocol revealed a high risk of bias in all eligible studies. In the analysis of the meta-analysis, the effect generated by the use of antioxidants was notorious in comparison with groups that were exposed to the same noise, without the use of antioxidant. Using the ABR responses at the most commonly used frequencies of 2,000–32,000 Hz as outcomes, it was possible to observe in all analyses an otoprotective effect caused by the use of the antioxidant.

Conclusion

This systematic review with meta-analysis demonstrated the variable otoprotective effect of the use of antioxidants on exposure to sound pressure levels in experimental studies with rodents, despite the high risk of bias and great heterogeneity of the selected studies.

Level of Evidence

1.

目的通过系统评价，探讨抗氧化剂对噪声暴露小鼠耳保护作用的发生机制。方法电子检索EMBASE、LILACS、PubMed/Medline、Scopus、Web of Science等数据库和截至2022年6月发表的灰色文献。在PICO策略中，研究人群包括暴露于高水平声压下的啮齿动物，干预包括使用抗氧化剂，与伴随使用安慰剂的比较，以及听觉测试（如诱发耳声发射和脑干听觉诱发电位）的结果以及组织学和免疫组织化学评估的结果。数值数据的分析根据Review Manager （Cochrane）进行，使用平均差异作为效果的度量。结果定性综合纳入研究35篇，定量综合纳入研究27篇。CAMARADES进行的分析表明，大多数纳入的研究都具有方法学质量，sycle RoB偏倚风险评估方案显示，所有符合条件的研究都存在高偏倚风险。在荟萃分析的分析中，使用抗氧化剂产生的效果与暴露于相同噪音但不使用抗氧化剂的组相比是臭名昭著的。使用最常用频率2000 - 32000 Hz的ABR响应作为结果，可以在所有分析中观察到使用抗氧化剂引起的耳保护作用。尽管所选研究存在较高的偏倚风险和较大的异质性，但本系统综述和荟萃分析表明，在啮齿动物实验研究中，使用抗氧化剂对暴露于声压水平的耳保护作用是可变的。证据水平

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引用次数: 0

Mendelian randomization and FinnGen analysis of the causal relationship between 473 gut microbiota species and chronic sinusitis 473种肠道菌群与慢性鼻窦炎因果关系的孟德尔随机化和FinnGen分析

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-09-25 DOI: 10.1016/j.bjorl.2025.101711

Chenguang Zhang , Yicong Wang , Chenghao Hu , Bin Guo , Huwei Jiang , Chunlong Zhao , Yuwen Wang

Objective

To investigate the causal associations between Gut Microbiota (GM) and Chronic Sinusitis (CRS) using Mendelian Randomization (MR).

Methods

Genome-Wide Association Study (GWAS) summary statistics for 473 GM taxa were obtained from MiBioGen consortium. CRS data (22,099 cases vs. 371,520 controls) were sourced from the FinnGen R12 cohort. Causal effects were estimated via Inverse Variance-Weighted (IVW), MR-Egger, weighted median, and Bayesian-weighted MR methods. Sensitivity analyses (heterogeneity and horizontal pleiotropy tests) were performed to validate robustness.

Results

IVW analysis identified 20 GM taxa significantly associated with CRS risk (p < 0.05). Of these, 7 taxa (e.g., Francisellales, Roseibacillus, Merdibacter massiliensis) exhibited risk-increasing effects, while 13 taxa (e.g., Firmicutes I, Succinivibrionaceae) showed protective effects. Sensitivity analyses confirmed the absence of significant heterogeneity (Cochran’s Q p > 0.05) or pleiotropy (MR-Egger intercept p > 0.05). Bayesian-weighted MR validated 18 causal relationships (posterior probability > 95%), except for RUG420 sp900317985 and UBA7703 (non-significant).

Conclusions

This MR study provides genetic evidence supporting causal roles of specific GM taxa in CRS pathogenesis. These findings highlight the gut-sinus axis as a potential therapeutic target and underscore the utility of large-scale biobanks (e.g., FinnGen) in advancing precision medicine.

Level of evidence

Level 5. Mendelian Randomized (MR) studies are second only to randomized controlled trials in terms of the level of evidence.

目的应用孟德尔随机化（MR）方法探讨肠道菌群（GM）与慢性鼻窦炎（CRS）的因果关系。方法从MiBioGen联盟中获取473个GM分类群的GWAS汇总统计数据。CRS数据（22,099例与371,520例对照）来自FinnGen R12队列。通过反方差加权（IVW）、MR- egger、加权中位数和贝叶斯加权MR方法估计因果效应。进行敏感性分析（异质性和水平多效性试验）以验证稳健性。结果vw分析发现20个GM分类群与CRS风险显著相关（p < 0.05）。其中7个类群（Francisellales、Roseibacillus、Merdibacter massiliensis）表现出增加风险的作用，13个类群（Firmicutes I、Succinivibrionaceae）表现出保护作用。敏感性分析证实不存在显著异质性（Cochran’s Q p > 0.05）或多效性（MR-Egger截距p >； 0.05）。贝叶斯加权MR验证了18个因果关系（后验概率>； 95%），除了RUG420 sp900317985和UBA7703（不显著）。结论本MR研究提供了支持特定转基因分类群在CRS发病机制中的因果作用的遗传学证据。这些发现突出了肠窦轴作为一个潜在的治疗靶点，并强调了大规模生物库（如FinnGen）在推进精准医学方面的效用。证据等级：5级。孟德尔随机（MR）研究在证据水平方面仅次于随机对照试验。

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引用次数: 0

Estrogenic/Progestin therapy and the development of Vestibular Schwannoma: A systematic review and meta-analysis 雌激素/黄体酮治疗与前庭神经鞘瘤的发展：一项系统综述和荟萃分析

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-09-25 DOI: 10.1016/j.bjorl.2025.101706

Maria Vitória Graça Couto de Campos Amaral, Fayez Bahmad Jr

Objective

Compare the risk of developing Vestibular schwannoma in patients prescribed Hormone Therapy (HT).

Methods

We performed a systematic review in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA), the search was conducted in English, and we included all the studies that met the following criteria: (a) Participants who presented with VS; (b) Patients prescribed Hormone Replacement Therapy (HRT); (c) Prospective, retrospective or case-control study.

Results

Of the 146 articles, four met the inclusion criteria and were included in the systematic review and meta-analysis. Two studies documented an increased relative risk of Vestibular schwannoma in patients that had ever used hormone replacement therapy, another study found an incidence rate 2.2 times higher than the expected incidence rate and the other study indicated a 10% increased odds of the Vestibular Schwannoma in patients who have ever used hormone replacement therapy.

Conclusion

The use of hormone replacement therapy was associated with an increased relative risk of Vestibular Schwannoma but also demonstrated a lack of a definitive association.

Level of evidence

Level 1.

目的比较激素治疗（HT）患者发生前庭神经鞘瘤的风险。方法：我们按照系统评价和荟萃分析的首选报告项目（PRISMA）进行了系统评价，检索是用英文进行的，我们纳入了符合以下标准的所有研究：(a)出现VS的参与者；(b)给病人开的激素替代疗法；(c)前瞻性、回顾性或病例对照研究。结果146篇文章中，有4篇符合纳入标准，被纳入系统评价和meta分析。两项研究表明，曾经使用激素替代疗法的患者患前庭神经鞘瘤的相对风险增加，另一项研究发现，发病率比预期的发病率高2.2倍，另一项研究表明，曾经使用激素替代疗法的患者患前庭神经鞘瘤的几率增加10%。结论激素替代疗法的使用与前庭神经鞘瘤的相对风险增加有关，但也缺乏明确的联系。证据等级：1级。

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引用次数: 0

Nomogram for predicting overall and cancer-specific survival in patients with postoperative follicular thyroid cancer 预测滤泡性甲状腺癌术后患者总体和癌症特异性生存的Nomogram

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-09-25 DOI: 10.1016/j.bjorl.2025.101719

Xin Liu , Suidan Chen , Cangui Wu

Objectives

In this research, nomograms were constructed from clinical variables in patients with postoperative Follicular Thyroid Cancer (FTC) to predict the survival of FTC patients.

Methods

Adult patients surgically treated for FTC from 2004 to 2015 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Significant clinical variables were screened using univariate analysis and further screened with multivariate Cox regression analysis, which were used to construct nomogram models for Overall Survival (OS) and Cancer-Specific Survival (CSS).

Results

Age, sex, marital status, tumor size, glandular invasion status, N stage and M stage were identified as the clinical variables affecting the OS in FTC patients. Additionally, all variables, except sex, were found to have an impact on the CSS in FTC patients. The c-index shows agreement between the predicted results and the actual observed results, and the calibration curve of the probability of survival also shows agreement between the predicted plot and the actual observations.

Conclusions

Our study successfully built a nomogram of OS and CSS for FTC patients who had undergone surgery.

Level of evidence

IV: Retrospective cohort study.

目的通过对术后滤泡性甲状腺癌（FTC）患者的临床变量进行形态学分析，以预测FTC患者的生存。方法从监测、流行病学和最终结果（SEER）数据库中选择2004 - 2015年手术治疗的成年FTC患者。采用单因素分析筛选有意义的临床变量，并进一步采用多因素Cox回归分析筛选，构建总生存期（OS）和癌症特异性生存期（CSS）的nomogram模型。结果年龄、性别、婚姻状况、肿瘤大小、腺体浸润情况、N分期、M分期是影响FTC患者OS的临床变量。此外，除性别外，所有变量都对FTC患者的CSS有影响。c指数表明预测结果与实际观测结果吻合，生存概率校正曲线也表明预测图与实际观测值吻合。结论我们的研究成功构建了FTC手术患者的OS和CSS的nomogram。证据水平iv：回顾性队列研究。

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引用次数: 0

Experimental comparison of platelet-rich plasma with conventional treatment in rats with acoustic trauma induced hearing loss 富血小板血浆治疗与常规治疗对大鼠听觉损伤性听力损失的实验比较

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology

Pub Date : 2025-09-25 DOI: 10.1016/j.bjorl.2025.101712

Funda Kutay, Mehmet Ihsan Gülmez, Semsettin Okuyucu

Objective

This study aimed to test at an experimental level the contributions of traditional treatments with Platelet Rich Plasma (PRP) to the recovery of hearing in hearing loss due to acoustic trauma.

Methods

Thirty healthy adult rats were used in the study. Otoacoustic Emission (OAE) measurements were performed before the study. All rats with OAE measurements were exposed to 95 dB pure tone sound at a frequency of 4 kHz for 60-minutes. OAEs of the experimental animals were measured again at the 24th hour and it was determined that acoustic trauma had occurred. The rats were divided into 3 groups of 10, the first group was the control group, the 2nd group was determined as the group in which approximately 0.5 mL of intratympanic PRP was injected for 5 doses with 2 days intervals, and the 3rd group was determined as the group in which approximately 0.5 mL of intratympanic steroid was injected with 2 days intervals. OAE measurements made after 7 and 21 days were evaluated, and the treatments given were compared to the group without treatment.

Results

The results obtained from day-by-day and frequency-by-frequency measurements of DPOAE were statistically compared to check whether significant results were obtained. It was determined that better results were obtained in rats with acoustic trauma treated with PRP and prednol compared with acoustic trauma who received no treatment, and close treatment efficacy results were found between PRP and prednol groups.

Conclusion

When DPOAE measurements of these three groups at 4 kHz frequency on various days were compared with Group 1, a significant statistical difference was observed in Groups 2 and 3, but no significant difference was found between Groups 2 and 3. It was concluded that PRP is as effective as steroids in the improvement of hearing.

目的在实验水平上探讨富血小板血浆（PRP）治疗对听力学损伤所致听力损失患者听力恢复的作用。方法选用健康成年大鼠30只。在研究前进行了耳声发射（OAE）测量。所有OAE测量的大鼠暴露在频率为4 kHz的95 dB纯音中60分钟。24小时再次测量实验动物的oae，确定已发生声损伤。将大鼠分为3组，每组10只，第一组为对照组，第二组为鼓内PRP注射约0.5 mL，连续5次，间隔2天，第三组为鼓内类固醇注射约0.5 mL，间隔2天。评估7天和21天后的OAE测量，并将给予治疗的组与未给予治疗的组进行比较。结果将DPOAE逐日测量结果与逐次测量结果进行统计学比较，检查是否有显著性结果。结果表明，PRP + preprenol对听损伤大鼠的治疗效果优于未治疗的听损伤大鼠，且PRP组与preprenol组治疗效果相近。结论3组4 kHz频率各天DPOAE测量值与1组比较，2、3组差异有统计学意义，2、3组差异无统计学意义。结论PRP在改善听力方面与类固醇具有同等效果。

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