Pub Date : 2026-03-01Epub Date: 2026-01-17DOI: 10.1016/j.bjorl.2025.101749
Amanda Sampaio Almeida, José Ricardo Gurgel Testa
{"title":"How to teach otologic surgery to the next generation?","authors":"Amanda Sampaio Almeida, José Ricardo Gurgel Testa","doi":"10.1016/j.bjorl.2025.101749","DOIUrl":"10.1016/j.bjorl.2025.101749","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101749"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-28DOI: 10.1016/j.bjorl.2025.101739
Anchi Sun , Rongrong Lv , Zhiwei Xing , Yifan He , Xiaomin Wang , Hui Li , Qianqian Shao
Objective
The prevalence of Nasopharyngeal Carcinoma (NPC) is increasing, and the mortality of patients with cisplatin resistance is high. In this study, we aimed to elucidate several potential mechanisms of miR-199a-5p in regulating the progression and cisplatin resistance of NPC.
Methods
Relevant datasets were downloaded from the Gene Expression Omnibus (GEO) database to verify miR-199a-5p expression in NPC. The miR-199a-5p level was evaluated by RT-qPCR, and the prognostic significance was analyzed by K–M curve. Cell proliferation, migration, invasion and apoptosis were detected in vitro. The contents of Epithelial-Mesenchymal Transition (EMT) protein, apoptosis protein and SLC1A5 protein were detected by Western immunoblotting. DLR assay elucidated that miR-199a-5p targets SLC1A5. The effect of miR-199a-5p on subcutaneous tumor in nude mice was detected in vivo.
Results
We found that miR-199a-5p was differentially expressed in nasopharyngeal carcinoma, and patients with high expression showed good prognosis. It was also found to be associated with cisplatin resistance and showed low expression in HNE1/DDP cells. The up-regulation of miR-199a-5p can inhibit the proliferation, migration and invasion of NPC cells, and enhance cell apoptosis. The mechanism may be achieved by targeting SLC1A5.
Conclusion
The high expression of miR-199a-5p can inhibit SLC1A5 and thus the progression of NPC. At the same time, the high expression of miR-199a-5p can increase the sensitivity of NPC to cisplatin.
Level of evidence
Level 5.
目的鼻咽癌（NPC）的发病率呈上升趋势，顺铂耐药患者的死亡率较高。在这项研究中，我们旨在阐明miR-199a-5p调节鼻咽癌进展和顺铂耐药的几种潜在机制。方法从Gene Expression Omnibus （GEO）数据库下载相关数据集，验证miR-199a-5p在NPC中的表达。RT-qPCR检测miR-199a-5p水平，K-M曲线分析预后意义。体外检测细胞增殖、迁移、侵袭和凋亡。Western免疫印迹法检测上皮-间质转化（Epithelial-Mesenchymal Transition， EMT）蛋白、凋亡蛋白和SLC1A5蛋白的含量。DLR分析证实miR-199a-5p靶向SLC1A5。在体内检测miR-199a-5p对裸鼠皮下肿瘤的影响。结果我们发现miR-199a-5p在鼻咽癌中存在差异表达，高表达患者预后良好。它也被发现与顺铂耐药有关，并在HNE1/DDP细胞中低表达。上调miR-199a-5p可抑制鼻咽癌细胞的增殖、迁移和侵袭，促进细胞凋亡。其机制可能通过靶向SLC1A5来实现。结论miR-199a-5p高表达可抑制SLC1A5，从而抑制鼻咽癌的进展。同时，miR-199a-5p的高表达可增加鼻咽癌对顺铂的敏感性。证据等级：5级。
{"title":"miR-199a-5p inhibits malignant progression and enhances cisplatin sensitivity of nasopharyngeal carcinoma by targeting SLC1A5","authors":"Anchi Sun , Rongrong Lv , Zhiwei Xing , Yifan He , Xiaomin Wang , Hui Li , Qianqian Shao","doi":"10.1016/j.bjorl.2025.101739","DOIUrl":"10.1016/j.bjorl.2025.101739","url":null,"abstract":"<div><h3>Objective</h3><div>The prevalence of Nasopharyngeal Carcinoma (NPC) is increasing, and the mortality of patients with cisplatin resistance is high. In this study, we aimed to elucidate several potential mechanisms of miR-199a-5p in regulating the progression and cisplatin resistance of NPC.</div></div><div><h3>Methods</h3><div>Relevant datasets were downloaded from the Gene Expression Omnibus (GEO) database to verify miR-199a-5p expression in NPC. The miR-199a-5p level was evaluated by RT-qPCR, and the prognostic significance was analyzed by K–M curve. Cell proliferation, migration, invasion and apoptosis were detected in vitro. The contents of Epithelial-Mesenchymal Transition (EMT) protein, apoptosis protein and SLC1A5 protein were detected by Western immunoblotting. DLR assay elucidated that miR-199a-5p targets SLC1A5. The effect of miR-199a-5p on subcutaneous tumor in nude mice was detected in vivo.</div></div><div><h3>Results</h3><div>We found that miR-199a-5p was differentially expressed in nasopharyngeal carcinoma, and patients with high expression showed good prognosis. It was also found to be associated with cisplatin resistance and showed low expression in HNE1/DDP cells. The up-regulation of miR-199a-5p can inhibit the proliferation, migration and invasion of NPC cells, and enhance cell apoptosis. The mechanism may be achieved by targeting SLC1A5.</div></div><div><h3>Conclusion</h3><div>The high expression of miR-199a-5p can inhibit SLC1A5 and thus the progression of NPC. At the same time, the high expression of miR-199a-5p can increase the sensitivity of NPC to cisplatin.</div></div><div><h3>Level of evidence</h3><div>Level 5.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101739"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-07DOI: 10.1016/j.bjorl.2025.101747
Ying Mu , Yacheng Lu , Wei Fu
Objectives
This study aimed to use Mendelian Randomization (MR) method to explore the potential causal association of triglyceride and cholesterol on the risk of vestibular vertigo and potential mediating factors.
Methods
We extracted genetic variants associated with triglyceride and cholesterol from the genome-wide association study. Univariable two-sample MR were performed to evaluate the effects of triglyceride and cholesterol on the vestibular vertigo. Besides, Multivariate MR (MVMR) was used to estimate direct effects of triglyceride and cholesterol on the vestibular vertigo after adjusting for potential mediating factors. We also performed that a two-step mediation MR framework to elucidate potential mediators and to estimate the proportion of the association mediated.
Results
Genetically predicted triglyceride and cholesterol were positively associated with the risk of vestibular vertigo. In the MVMR analysis, causal associations between triglyceride and cholesterol with vestibular vertigo remained stable and robust after adjusting for body mass index, hypertension, and type 2 diabetes, whereas the association between triglyceride and cholesterol and the risk of vestibular vertigo became nonsignificant after adjusting for vitamin D. In the mediation analysis, we found that the causal effect of cholesterol on vestibular vertigo might partly mediated by vitamin D.
Conclusion
The present study provides robust evidence that genetically predicted triglyceride and cholesterol are independently causally associated with the risk of vestibular vertigo. Vitamin D also was found to mediate the causal pathways between cholesterol and vestibular vertigo.
{"title":"Association of triglyceride and cholesterol with vestibular vertigo: Evidence from univariable and multivariable mendelian randomization and mediation analysis","authors":"Ying Mu , Yacheng Lu , Wei Fu","doi":"10.1016/j.bjorl.2025.101747","DOIUrl":"10.1016/j.bjorl.2025.101747","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to use Mendelian Randomization (MR) method to explore the potential causal association of triglyceride and cholesterol on the risk of vestibular vertigo and potential mediating factors.</div></div><div><h3>Methods</h3><div>We extracted genetic variants associated with triglyceride and cholesterol from the genome-wide association study. Univariable two-sample MR were performed to evaluate the effects of triglyceride and cholesterol on the vestibular vertigo. Besides, Multivariate MR (MVMR) was used to estimate direct effects of triglyceride and cholesterol on the vestibular vertigo after adjusting for potential mediating factors. We also performed that a two-step mediation MR framework to elucidate potential mediators and to estimate the proportion of the association mediated.</div></div><div><h3>Results</h3><div>Genetically predicted triglyceride and cholesterol were positively associated with the risk of vestibular vertigo. In the MVMR analysis, causal associations between triglyceride and cholesterol with vestibular vertigo remained stable and robust after adjusting for body mass index, hypertension, and type 2 diabetes, whereas the association between triglyceride and cholesterol and the risk of vestibular vertigo became nonsignificant after adjusting for vitamin D. In the mediation analysis, we found that the causal effect of cholesterol on vestibular vertigo might partly mediated by vitamin D.</div></div><div><h3>Conclusion</h3><div>The present study provides robust evidence that genetically predicted triglyceride and cholesterol are independently causally associated with the risk of vestibular vertigo. Vitamin D also was found to mediate the causal pathways between cholesterol and vestibular vertigo.</div></div><div><h3>Level of evidence</h3><div>Level III.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101747"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-05DOI: 10.1016/j.bjorl.2026.101769
Huazhen Zhu , Yongyu Wang , Haoen Zhang , Qi Kang , Lei Xu , Ji Chen , Chen Chen , Jianqing Tao
Objective
To evaluate the clinical efficacy of Chinese Herbal Medicine (CHM) in treating Allergic Rhinitis (AR) through meta‐analysis.
Methods
A meta‐analysis was conducted using a random effects model to explore the impact of CHM on response rates, nasal symptom scores, quality of life, blood Immunoglobulin E (IgE) levels, and adverse reactions.
Results
A total of 1,326 articles were retrieved, of which 12 studies were included. The meta‐analysis showed that the response rate in the experimental group was higher than in the control group (p < 0.001). The adverse reaction rate was lower in the experimental group compared with the control group (p = 0.003). Subgroup analysis by publication year indicated that studies published in 2024 and 2023 showed lower nasal congestion scores in the experimental group compared with the control group (p < 0.0001); nasal itching scores were lower in the experimental group than in the control group (p < 0.0001). Subgroup analysis by age revealed that the 30+ and 40+ age groups had lower nasal itching scores, sneezing scores and rhinorrhea scores in the experimental group compared with the control group (p < 0.0001). Blood IgE levels were also lower in the experimental group compared with the control group (p = 0.002). Scores for the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) were lower in the experimental group (p < 0.0001).
Conclusion
The current evidence suggests that CHM can enhance the efficacy of AR treatment, improve patients’ quality of life, and result in a lower rate of adverse reactions.
{"title":"Efficacy of Chinese herbal medicine in allergic rhinitis: a meta‐analysis","authors":"Huazhen Zhu , Yongyu Wang , Haoen Zhang , Qi Kang , Lei Xu , Ji Chen , Chen Chen , Jianqing Tao","doi":"10.1016/j.bjorl.2026.101769","DOIUrl":"10.1016/j.bjorl.2026.101769","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the clinical efficacy of Chinese Herbal Medicine (CHM) in treating Allergic Rhinitis (AR) through meta‐analysis.</div></div><div><h3>Methods</h3><div>A meta‐analysis was conducted using a random effects model to explore the impact of CHM on response rates, nasal symptom scores, quality of life, blood Immunoglobulin E (IgE) levels, and adverse reactions.</div></div><div><h3>Results</h3><div>A total of 1,326 articles were retrieved, of which 12 studies were included. The meta‐analysis showed that the response rate in the experimental group was higher than in the control group (p < 0.001). The adverse reaction rate was lower in the experimental group compared with the control group (p = 0.003). Subgroup analysis by publication year indicated that studies published in 2024 and 2023 showed lower nasal congestion scores in the experimental group compared with the control group (p < 0.0001); nasal itching scores were lower in the experimental group than in the control group (p < 0.0001). Subgroup analysis by age revealed that the 30+ and 40+ age groups had lower nasal itching scores, sneezing scores and rhinorrhea scores in the experimental group compared with the control group (p < 0.0001). Blood IgE levels were also lower in the experimental group compared with the control group (p = 0.002). Scores for the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) were lower in the experimental group (p < 0.0001).</div></div><div><h3>Conclusion</h3><div>The current evidence suggests that CHM can enhance the efficacy of AR treatment, improve patients’ quality of life, and result in a lower rate of adverse reactions.</div></div><div><h3>Level of evidence</h3><div>I.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101769"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-07DOI: 10.1016/j.bjorl.2025.101748
Renata Tadeu Ramirez Garcia , Antonio Carlos dos Santos , Fabiana Danieli-Hyppolito , Miguel Angelo Hyppolito
Objective
To propose a protocol for image-guided implant placement estimation, combining 3D reconstruction of preoperative Computed Tomography (CT) images and a guide-marker, for individuals undergoing percutaneous Bone Conduction Hearing Devices (BCHD).
Methods
Fifty-one subjects aged 6- to 75-years undergoing percutaneous BCHD surgery were included. Three optional implant points were estimated and marked using a guide-marker, and compared with preoperative CT images to define optimal placement. A peer validation was conducted by two independent reviewers to assess the replicability of the protocol in clinical practice.
Results
Bilateral CT images were obtained from all 51 subjects, and a total of 54 BCHD surgeries were performed. Relevant findings, including mastoid cells (19.6%), cranial suture lines (27.5%), perforating vessels (13.7%), bone surface irregularities (1.9%), venous lakes (9.8%), and fixation plates (3.9%) were identified in 52.9% of subjects, and they affected the implant placement in 37.3% of cases. There was moderate agreement between the reviewers regarding implant placement in both right and left ears, and in relation to the actual implant placement performed during the surgical procedure.
Conclusion
The image-guided implant placement estimation, combining 3D reconstruction of preoperative Computed Tomography (CT) images and a guide-marker, has proven reliable and effective for estimating optimal implant placement in subjects undergoing percutaneous BCHD surgery, thereby constituting a valuable tool for clinical practice.
{"title":"Image-guided protocol with a guide-marker for bone conduction hearing implant placement estimation","authors":"Renata Tadeu Ramirez Garcia , Antonio Carlos dos Santos , Fabiana Danieli-Hyppolito , Miguel Angelo Hyppolito","doi":"10.1016/j.bjorl.2025.101748","DOIUrl":"10.1016/j.bjorl.2025.101748","url":null,"abstract":"<div><h3>Objective</h3><div>To propose a protocol for image-guided implant placement estimation, combining 3D reconstruction of preoperative Computed Tomography (CT) images and a guide-marker, for individuals undergoing percutaneous Bone Conduction Hearing Devices (BCHD).</div></div><div><h3>Methods</h3><div>Fifty-one subjects aged 6- to 75-years undergoing percutaneous BCHD surgery were included. Three optional implant points were estimated and marked using a guide-marker, and compared with preoperative CT images to define optimal placement. A peer validation was conducted by two independent reviewers to assess the replicability of the protocol in clinical practice.</div></div><div><h3>Results</h3><div>Bilateral CT images were obtained from all 51 subjects, and a total of 54 BCHD surgeries were performed. Relevant findings, including mastoid cells (19.6%), cranial suture lines (27.5%), perforating vessels (13.7%), bone surface irregularities (1.9%), venous lakes (9.8%), and fixation plates (3.9%) were identified in 52.9% of subjects, and they affected the implant placement in 37.3% of cases. There was moderate agreement between the reviewers regarding implant placement in both right and left ears, and in relation to the actual implant placement performed during the surgical procedure.</div></div><div><h3>Conclusion</h3><div>The image-guided implant placement estimation, combining 3D reconstruction of preoperative Computed Tomography (CT) images and a guide-marker, has proven reliable and effective for estimating optimal implant placement in subjects undergoing percutaneous BCHD surgery, thereby constituting a valuable tool for clinical practice.</div></div><div><h3>Level of evidence</h3><div>2.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101748"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-07DOI: 10.1016/j.bjorl.2025.101751
Cheng Li , Yan Mei , Wei Li , Dan Liu
Objective
To develop and evaluate a predictive model for cognitive impairment, assessed by a brief cognitive test, among middle-aged and older adults with self-reported hearing loss, aiming to facilitate early identification and targeted intervention in high-risk populations.
Methods
This study utilized data from the 2011–2018 waves of the China Health and Retirement Longitudinal Study, including 1,093 individuals aged 45 and above with self-reported hearing impairment but normal cognition at baseline. The average follow-up duration was 5.2-years. Cognitive impairment was defined as a total cognitive score at least one standard deviation below the mean for the corresponding age group. Univariate and multivariate Cox proportional hazards models were used to identify independent predictors, and a nomogram was constructed based on significant variables. Model performance was assessed using calibration curves, time-dependent Concordance indices (C-index), and the Area Under the receiver operating Characteristic Curve (AUC). Risk stratification analysis was conducted across various sociodemographic subgroups.
Results
During follow-up, 152 individuals (13.9%) developed cognitive impairment. Higher education level, urban residence, and participation in leisure social activities (e.g., playing mahjong) were independently associated with lower risk of cognitive impairment. The nomogram demonstrated good discriminative performance, with AUCs of 0.728, 0.762, and 0.768, and corresponding time-dependent C-indices of 0.719, 0.761, and 0.767 at 3-, 5-, and 6-year follow-up points, respectively. Calibration plots indicated good agreement between predicted and observed risks. Risk scores varied significantly across subgroups defined by sex, age, education level, and residential location. Kaplan–Meier analyses confirmed the model’s effective risk stratification capability.
Conclusion
This study presents the first predictive model tailored to cognitive risk heterogeneity among older adults with self-reported hearing loss. By incorporating a brief cognitive test, the nomogram demonstrated reliable performance and holds potential for use in risk stratification, population screening, and personalized preventive interventions.
Level of evidence
2 ‒ Prospective cohort study based on the longitudinal CHARLS data.
{"title":"Nomogram for predicting cognitive impairment in middle-aged and elderly individuals with self-reported hearing loss: Insights from the longitudinal CHARLS cohort","authors":"Cheng Li , Yan Mei , Wei Li , Dan Liu","doi":"10.1016/j.bjorl.2025.101751","DOIUrl":"10.1016/j.bjorl.2025.101751","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and evaluate a predictive model for cognitive impairment, assessed by a brief cognitive test, among middle-aged and older adults with self-reported hearing loss, aiming to facilitate early identification and targeted intervention in high-risk populations.</div></div><div><h3>Methods</h3><div>This study utilized data from the 2011–2018 waves of the China Health and Retirement Longitudinal Study, including 1,093 individuals aged 45 and above with self-reported hearing impairment but normal cognition at baseline. The average follow-up duration was 5.2-years. Cognitive impairment was defined as a total cognitive score at least one standard deviation below the mean for the corresponding age group. Univariate and multivariate Cox proportional hazards models were used to identify independent predictors, and a nomogram was constructed based on significant variables. Model performance was assessed using calibration curves, time-dependent Concordance indices (C-index), and the Area Under the receiver operating Characteristic Curve (AUC). Risk stratification analysis was conducted across various sociodemographic subgroups.</div></div><div><h3>Results</h3><div>During follow-up, 152 individuals (13.9%) developed cognitive impairment. Higher education level, urban residence, and participation in leisure social activities (e.g., playing mahjong) were independently associated with lower risk of cognitive impairment. The nomogram demonstrated good discriminative performance, with AUCs of 0.728, 0.762, and 0.768, and corresponding time-dependent C-indices of 0.719, 0.761, and 0.767 at 3-, 5-, and 6-year follow-up points, respectively. Calibration plots indicated good agreement between predicted and observed risks. Risk scores varied significantly across subgroups defined by sex, age, education level, and residential location. Kaplan–Meier analyses confirmed the model’s effective risk stratification capability.</div></div><div><h3>Conclusion</h3><div>This study presents the first predictive model tailored to cognitive risk heterogeneity among older adults with self-reported hearing loss. By incorporating a brief cognitive test, the nomogram demonstrated reliable performance and holds potential for use in risk stratification, population screening, and personalized preventive interventions.</div></div><div><h3>Level of evidence</h3><div>2 ‒ Prospective cohort study based on the longitudinal CHARLS data.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101751"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-17DOI: 10.1016/j.bjorl.2026.101761
José Fernando Polanski , Anelyse Pulner Agulham , Beatriz Alvarez Mattar , Anne Karoline Groth , Marja Cristiane Reksidler
{"title":"Simultaneous intraparotid and intratemporal facial nerve schwannoma: resection of the lesion and nerve reconstruction with cross-face technique ‒ Case report","authors":"José Fernando Polanski , Anelyse Pulner Agulham , Beatriz Alvarez Mattar , Anne Karoline Groth , Marja Cristiane Reksidler","doi":"10.1016/j.bjorl.2026.101761","DOIUrl":"10.1016/j.bjorl.2026.101761","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101761"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-23DOI: 10.1016/j.bjorl.2026.101760
BinBin Wang, Feng Liu, Bo Wei
Objective
To evaluate the efficacy and safety of corticosteroids in Chronic Rhinosinusitis (CRS), focusing on health-related quality of life, disease severity, systemic steroid-sparing effects, and Serious Adverse Events (SAEs).
Methods
Following PRISMA 2020 guidelines, PubMed, Web of Science, and Cochrane CENTRAL were systematically searched for randomized and non-randomized studies in adults with CRS. Outcomes included SNOT-22 scores, endoscopic findings, systemic corticosteroid use, and SAEs. Risk of bias was assessed using RoB 2.0 and Newcastle-Ottawa Scale. Meta-analyses employed random-effects models, with pooled estimates reported as Mean Differences (MD) or Odds Ratios (OR) and 95% Confidence Intervals (95% CI).
Results
Eleven studies (3,542 patients) were included. Corticosteroid therapy significantly improved SNOT-22 scores (MD = −16.00, 95% CI: −18.91 to −13.09, p < 0.0001; I² = 90.3%) and endoscopic outcomes (MD = −2.32, 95% CI: −2.71 to −1.94, p < 0.001; I² = 61.2%). Local corticosteroids reduced systemic steroid dependence (OR = 0.30, 95% CI: 0.27–0.34, p < 0.0001; I² = 0%). No statistically significant increase in SAEs was observed (OR = 1.47, 95% CI: 0.44–4.93, p = 0.9848; I² = 0%). Heterogeneity was high for SNOT-22 and endoscopic outcomes, but funnel plots showed no major publication bias.
Conclusion
Corticosteroids improve quality of life and objective disease measures in CRS while reducing reliance on systemic steroids, with no significant increase in SAEs. Future studies should compare delivery modalities, assess long-term safety, and explore biomarker-guided strategies.
{"title":"Efficacy and safety of corticosteroids in the management of chronic rhinosinusitis: A systematic review and meta-analysis of randomized and non-randomized studies","authors":"BinBin Wang, Feng Liu, Bo Wei","doi":"10.1016/j.bjorl.2026.101760","DOIUrl":"10.1016/j.bjorl.2026.101760","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of corticosteroids in Chronic Rhinosinusitis (CRS), focusing on health-related quality of life, disease severity, systemic steroid-sparing effects, and Serious Adverse Events (SAEs).</div></div><div><h3>Methods</h3><div>Following PRISMA 2020 guidelines, PubMed, Web of Science, and Cochrane CENTRAL were systematically searched for randomized and non-randomized studies in adults with CRS. Outcomes included SNOT-22 scores, endoscopic findings, systemic corticosteroid use, and SAEs. Risk of bias was assessed using RoB 2.0 and Newcastle-Ottawa Scale. Meta-analyses employed random-effects models, with pooled estimates reported as Mean Differences (MD) or Odds Ratios (OR) and 95% Confidence Intervals (95% CI).</div></div><div><h3>Results</h3><div>Eleven studies (3,542 patients) were included. Corticosteroid therapy significantly improved SNOT-22 scores (MD = −16.00, 95% CI: −18.91 to −13.09, <em>p</em> < 0.0001; I² = 90.3%) and endoscopic outcomes (MD = −2.32, 95% CI: −2.71 to −1.94, <em>p</em> < 0.001; I² = 61.2%). Local corticosteroids reduced systemic steroid dependence (OR = 0.30, 95% CI: 0.27–0.34, <em>p</em> < 0.0001; I² = 0%). No statistically significant increase in SAEs was observed (OR = 1.47, 95% CI: 0.44–4.93, <em>p</em> = 0.9848; I² = 0%). Heterogeneity was high for SNOT-22 and endoscopic outcomes, but funnel plots showed no major publication bias.</div></div><div><h3>Conclusion</h3><div>Corticosteroids improve quality of life and objective disease measures in CRS while reducing reliance on systemic steroids, with no significant increase in SAEs. Future studies should compare delivery modalities, assess long-term safety, and explore biomarker-guided strategies.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101760"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-08DOI: 10.1016/j.bjorl.2025.101750
Marcelo Augusto Antonio , Sergio Lopes Fernandes Ramos , Fernando Augusto Lima Marson , Mariana Dalbo Contrera Toro , Eulalia Sakano
Objectives
To develop and evaluate the anatomical accuracy and haptic fidelity of an affordable kit consisting of a silicone head, a foam support, and a 3D-printed biomodel of the paranasal sinuses for surgical training.
Methods
This single-center, technological, and interventional study detailed the development of a human sinus biomodel. Its anatomical and haptic evaluation was conducted by ten senior rhinologists, who performed 37 standard surgical tasks. Participants rated similarity to fresh cadaveric dissection on a 5-point Likert scale. Computed tomographic images were converted into a standard tessellation file through a combination of automatic and manual segmentation. This file was then used in a 3D printer to create the biomodel, which was customized with a red silicone coating to emulate mucosa, as well as silicone-insulated wire and acrylic yarn to simulate arteries and nerves. The model was mounted onto a silicone head and foam support, with a total production cost of US$ 43.37.
Results
The similarity of anatomic landmarks scored a mean above 4.0 ± SD on both sides. The lacrimal bone drilling/debulking procedure was somewhat suboptimal for exposing the lacrimal sac, scoring a mean of 3.1 ± 1.04 on the left side but 4.3 ± 0.64 on the right. Likewise, uncinectomy was rated 3.4 ± 1.02 on the left and 3.7 ± 0.90 on the right, while the periorbit incision received scores of 3.5 ± 0.92 on the left and 4.5 ± 0.50 on the right. All other steps received ratings above 4.0 ± SD.
Conclusion
This study presents a fully reproducible and cost-effective method for constructing a 3D sinus biomodel. The model demonstrated high anatomical and haptic fidelity, as validated by senior rhinologists, making it a valuable tool for surgical training in sinonasal procedures.
{"title":"An affordable and optimized 3D biomodel for sinonasal surgery training","authors":"Marcelo Augusto Antonio , Sergio Lopes Fernandes Ramos , Fernando Augusto Lima Marson , Mariana Dalbo Contrera Toro , Eulalia Sakano","doi":"10.1016/j.bjorl.2025.101750","DOIUrl":"10.1016/j.bjorl.2025.101750","url":null,"abstract":"<div><h3>Objectives</h3><div>To develop and evaluate the anatomical accuracy and haptic fidelity of an affordable kit consisting of a silicone head, a foam support, and a 3D-printed biomodel of the paranasal sinuses for surgical training.</div></div><div><h3>Methods</h3><div>This single-center, technological, and interventional study detailed the development of a human sinus biomodel. Its anatomical and haptic evaluation was conducted by ten senior rhinologists, who performed 37 standard surgical tasks. Participants rated similarity to fresh cadaveric dissection on a 5-point Likert scale. Computed tomographic images were converted into a standard tessellation file through a combination of automatic and manual segmentation. This file was then used in a 3D printer to create the biomodel, which was customized with a red silicone coating to emulate mucosa, as well as silicone-insulated wire and acrylic yarn to simulate arteries and nerves. The model was mounted onto a silicone head and foam support, with a total production cost of US$ 43.37.</div></div><div><h3>Results</h3><div>The similarity of anatomic landmarks scored a mean above 4.0 ± SD on both sides. The lacrimal bone drilling/debulking procedure was somewhat suboptimal for exposing the lacrimal sac, scoring a mean of 3.1 ± 1.04 on the left side but 4.3 ± 0.64 on the right. Likewise, uncinectomy was rated 3.4 ± 1.02 on the left and 3.7 ± 0.90 on the right, while the periorbit incision received scores of 3.5 ± 0.92 on the left and 4.5 ± 0.50 on the right. All other steps received ratings above 4.0 ± SD.</div></div><div><h3>Conclusion</h3><div>This study presents a fully reproducible and cost-effective method for constructing a 3D sinus biomodel. The model demonstrated high anatomical and haptic fidelity, as validated by senior rhinologists, making it a valuable tool for surgical training in sinonasal procedures.</div></div><div><h3>Level of evidence</h3><div>This study provides Level 2 evidence.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"92 2","pages":"Article 101750"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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