Pub Date : 2024-08-03DOI: 10.1016/j.bjorl.2024.101483
Vanessa Silva Soledade , Ludimila Sobreira Sena , Lucas Gomes Patrocínio
Objective
To translate and validate the Facial Feminization Surgery Outcomes Evaluation in Brazilian Portuguese.
Methods
A standard back-translation method was applied to obtain the final Brazilian Portuguese language version. In total, 21 Brazilian native Portuguese speakers transgender women with surgical intent and 21 Brazilian native Portuguese speakers transgender women without surgical intent were included in the study. The FFSOE was administered to both groups and all patients underwent a test-retest two weeks later.
Results
The FFSOE showed a high internal consistency with Cronbach’s alpha greater than 0.8. The test-retest reliability was high with repeated measures being highly correlated in all items, except for item 3, where the difference was significant (p = 0.027).
Conclusion
The FFSOE showed reliability, internal consistency and reproducibility in the evaluations. It is easy to understand and quick to apply, making it a simple tool for pre- and post-operative assessment in facial feminization surgeries.
{"title":"Validation of the Brazilian Portuguese language version of the facial feminization surgery outcomes evaluation the Brazilian Portuguese language version of the FFSOE","authors":"Vanessa Silva Soledade , Ludimila Sobreira Sena , Lucas Gomes Patrocínio","doi":"10.1016/j.bjorl.2024.101483","DOIUrl":"10.1016/j.bjorl.2024.101483","url":null,"abstract":"<div><h3>Objective</h3><p>To translate and validate the Facial Feminization Surgery Outcomes Evaluation in Brazilian Portuguese.</p></div><div><h3>Methods</h3><p>A standard back-translation method was applied to obtain the final Brazilian Portuguese language version. In total, 21 Brazilian native Portuguese speakers transgender women with surgical intent and 21 Brazilian native Portuguese speakers transgender women without surgical intent were included in the study. The FFSOE was administered to both groups and all patients underwent a test-retest two weeks later.</p></div><div><h3>Results</h3><p>The FFSOE showed a high internal consistency with Cronbach’s alpha greater than 0.8. The test-retest reliability was high with repeated measures being highly correlated in all items, except for item 3, where the difference was significant (<em>p</em> = 0.027).</p></div><div><h3>Conclusion</h3><p>The FFSOE showed reliability, internal consistency and reproducibility in the evaluations. It is easy to understand and quick to apply, making it a simple tool for pre- and post-operative assessment in facial feminization surgeries.</p></div><div><h3>The Oxford 2011 Levels of Evidence</h3><p>Level 4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 6","pages":"Article 101483"},"PeriodicalIF":1.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000983/pdfft?md5=f99222a28274d320ebb0e731dc11f40e&pid=1-s2.0-S1808869424000983-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.1016/j.bjorl.2024.101474
Rafaela Negretti de Lima , Gisele Lourenço , Gustavo Jacob Lourenço , Lucia Figueiredo Mourão , Carmen Silvia Passos Lima
{"title":"Conventional swallowing training associated with electric stimulation for dysphagia following organ preservation treatment for head and neck cancer: Case report","authors":"Rafaela Negretti de Lima , Gisele Lourenço , Gustavo Jacob Lourenço , Lucia Figueiredo Mourão , Carmen Silvia Passos Lima","doi":"10.1016/j.bjorl.2024.101474","DOIUrl":"10.1016/j.bjorl.2024.101474","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 6","pages":"Article 101474"},"PeriodicalIF":1.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000892/pdfft?md5=9fcfd976a68b5db7671eff8062f08dc0&pid=1-s2.0-S1808869424000892-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-20DOI: 10.1016/j.bjorl.2024.101471
Ding-Ting Wang , Jian Luo , Hua-Jun Feng , Yuan-Yuan Wang
Objective
Nasopharyngeal Carcinoma (NPC) is a tumor with ethnic and geographic distribution characteristics. HOXA Transcript at the distal Tip (HOTTIP) has been confirmed to have cancer-promoting effects in various tumors. The aim of this study was to investigate the clinical significance of HOTTIP in the development of NPC and its role in prognostic assessment.
Methods
Reverse transcription real-time PCR was used to analyze the expression of HOTTIP in the serum of 122 NPC patients before treatment, 35 controls and 30 NPC patients after treatment, and the relationship between HOTTIP expression and the clinicopathological features and prognosis of NPC patients was analyzed. The NPC cell lines CNE1 and HNE1 stably overexpressing HOTTIP were constructed using the retroviral method. Plate clone formation assays, MTT assays, flow cytometry, and Transwell migration and invasion assays were used to investigate the effects of HOTTIP overexpression on the colony-formation ability, cell proliferation ability, apoptosis, and migration and invasion abilities of CNE1 and HNE1 cells, respectively.
Results
HOTTIP was highly expressed in NPC serum and cells compared with the control group; serum HOTTIP expression in NPC patients after treatment was significantly lower than that before treatment; Kaplan-Meier survival curve revealed that the Progression-Free Survival (PFS) and Overall Survival (OS) of the HOTTIP low-expression group were both better than those of the HOTTIP high-expression group; COX proportional hazard models showed that high HOTTIP expression was an independent risk factor for PFS in NPC patients. The overexpression of HOTTIP promoted the proliferation, migration and invasion abilities of CNE1 and HNE1 NPC cells and inhibited cell apoptosis in vitro cell experiments.
Conclusion
Increased HOTTIP expression in serum indicates a poor prognosis and may be used as a molecular marker and therapeutic target in NPC.
{"title":"Serum HOTTIP expression is upregulated in nasopharyngeal carcinoma patients and predicts poor prognosis","authors":"Ding-Ting Wang , Jian Luo , Hua-Jun Feng , Yuan-Yuan Wang","doi":"10.1016/j.bjorl.2024.101471","DOIUrl":"10.1016/j.bjorl.2024.101471","url":null,"abstract":"<div><h3>Objective</h3><div>Nasopharyngeal Carcinoma (NPC) is a tumor with ethnic and geographic distribution characteristics. HOXA Transcript at the distal Tip (HOTTIP) has been confirmed to have cancer-promoting effects in various tumors. The aim of this study was to investigate the clinical significance of HOTTIP in the development of NPC and its role in prognostic assessment.</div></div><div><h3>Methods</h3><div>Reverse transcription real-time PCR was used to analyze the expression of HOTTIP in the serum of 122 NPC patients before treatment, 35 controls and 30 NPC patients after treatment, and the relationship between HOTTIP expression and the clinicopathological features and prognosis of NPC patients was analyzed. The NPC cell lines CNE1 and HNE1 stably overexpressing HOTTIP were constructed using the retroviral method. Plate clone formation assays, MTT assays, flow cytometry, and Transwell migration and invasion assays were used to investigate the effects of HOTTIP overexpression on the colony-formation ability, cell proliferation ability, apoptosis, and migration and invasion abilities of CNE1 and HNE1 cells, respectively.</div></div><div><h3>Results</h3><div>HOTTIP was highly expressed in NPC serum and cells compared with the control group; serum HOTTIP expression in NPC patients after treatment was significantly lower than that before treatment; Kaplan-Meier survival curve revealed that the Progression-Free Survival (PFS) and Overall Survival (OS) of the HOTTIP low-expression group were both better than those of the HOTTIP high-expression group; COX proportional hazard models showed that high HOTTIP expression was an independent risk factor for PFS in NPC patients. The overexpression of HOTTIP promoted the proliferation, migration and invasion abilities of CNE1 and HNE1 NPC cells and inhibited cell apoptosis in vitro cell experiments.</div></div><div><h3>Conclusion</h3><div>Increased HOTTIP expression in serum indicates a poor prognosis and may be used as a molecular marker and therapeutic target in NPC.</div></div><div><h3>Level of Evidence</h3><div>4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 1","pages":"Article 101471"},"PeriodicalIF":1.7,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-20DOI: 10.1016/j.bjorl.2024.101473
Yanhong Wei , Fanglian Shu , Ying Dai , Aji Tan , Yanju Wang , Li Zhang , Yan Shu
Objective
To investigate the efficacy of cluster nursing intervention based on Enhanced Recovery After Surgery (ERAS) for xerostomia in chronic rhinosinusitis after nasal endoscopic surgery.
Methods
A total of 80 patients with chronic rhinosinusitis who underwent functional nasal endoscopic surgery between January 2020 and December 2021 were selected and randomly divided into a control group (n = 40) and an experimental group (n = 40). Patients in the control group were treated with general nursing, while ERAS-based cluster nursing intervention was adopted for the experimental group, in addition to general nursing. Xerostomia stage and comfort level were observed at 2 h, 6 h, 24 h and 48 h after surgery; negative emotions before and after nursing were also observed.
Results
After the intervention, the xerostomia stage and comfort level at 6, 24 and 48 after surgery were higher in the experimental group (p < 0.05). Negative emotions in the experimental group were lower after nursing (p < 0.001). The self-rating depression scale and self-rating anxiety scale scores increased after nursing in both two groups (p < 0.05).
Conclusion
Enhanced recovery after surgery-based cluster nursing intervention can alleviate xerostomia, improve patients' comfort levels, reduce their negative emotions and accelerate postoperative recovery.
Level of evidence
2.
方法 选取2020年1月至2021年12月期间接受功能性鼻内窥镜手术的80例慢性鼻窦炎患者,随机分为对照组(40例)和实验组(40例)。对照组患者采用普通护理,实验组患者除普通护理外,还采用基于ERAS的集束护理干预。结果干预后,实验组患者术后 2 h、6 h、24 h 和 48 h 的口腔干燥程度和舒适度较高(P <0.05)。实验组护理后的负面情绪较低(p <0.001)。结论基于集束护理干预的术后强化康复可缓解口腔异味,提高患者的舒适度,降低患者的负面情绪,加速术后康复。
{"title":"Application of enhanced recovery after surgery for oral dryness prevention after endoscopic sinus surgery","authors":"Yanhong Wei , Fanglian Shu , Ying Dai , Aji Tan , Yanju Wang , Li Zhang , Yan Shu","doi":"10.1016/j.bjorl.2024.101473","DOIUrl":"10.1016/j.bjorl.2024.101473","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the efficacy of cluster nursing intervention based on Enhanced Recovery After Surgery (ERAS) for xerostomia in chronic rhinosinusitis after nasal endoscopic surgery.</p></div><div><h3>Methods</h3><p>A total of 80 patients with chronic rhinosinusitis who underwent functional nasal endoscopic surgery between January 2020 and December 2021 were selected and randomly divided into a control group (n = 40) and an experimental group (n = 40). Patients in the control group were treated with general nursing, while ERAS-based cluster nursing intervention was adopted for the experimental group, in addition to general nursing. Xerostomia stage and comfort level were observed at 2 h, 6 h, 24 h and 48 h after surgery; negative emotions before and after nursing were also observed.</p></div><div><h3>Results</h3><p>After the intervention, the xerostomia stage and comfort level at 6, 24 and 48 after surgery were higher in the experimental group (<em>p</em> < 0.05). Negative emotions in the experimental group were lower after nursing (<em>p</em> < 0.001). The self-rating depression scale and self-rating anxiety scale scores increased after nursing in both two groups (<em>p</em> < 0.05).</p></div><div><h3>Conclusion</h3><p>Enhanced recovery after surgery-based cluster nursing intervention can alleviate xerostomia, improve patients' comfort levels, reduce their negative emotions and accelerate postoperative recovery.</p></div><div><h3>Level of evidence</h3><p>2.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 6","pages":"Article 101473"},"PeriodicalIF":1.7,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000880/pdfft?md5=85d9f3359953175e16d538aaec422c67&pid=1-s2.0-S1808869424000880-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Allergic diseases and Meniere's disease found to have a possible link in observational study. However, the potential causal relationship between the two is unclear. Therefore, we aimed to explore the causal relationship between allergic diseases and Meniere's disease using a new data analysis technique called bidirectional Mendelian randomization study.
Method
Summary-level statistics for Meniere's disease and three allergic diseases (asthma, allergic rhinitis, eczema/dermatitis) were obtained from large-scale genome-wide association studies. The inverse variance weighted method was used as the primary measure, supplemented by MR-Egger regression and the weighted median method. To ensure the reliability of the conclusions, Cochran's Q, MR-Egger intercept, MR-PRESSO test, leave-one-out test, and MR Steiger test were used.
Results
Inverse-variance weighted method showed asthma (p = 0.008, OR = 3.908, 95% CI 1.424–10.724, adjust_p = 0.024), allergic rhinitis (p = 0.026, OR = 24.714, 95% CI 1.479–412.827, adjust_p = 0.026) and eczema/dermatitis (p = 0.019, OR = 3725.954, 95% CI 3.795 to 3,658,399.580, adjust_p = 0.029) all had a significant effect on Meniere's disease. Reverse Mendelian randomization studies have shown that Meniere's disease does not increase the risk of three allergic diseases. Sensitivity analysis showed no horizontal pleiotropy and heterogeneity for each trait.
Conclusion
Our Mendelian randomization analysis supports a positive causal relationship between three allergic diseases (asthma, allergic rhinitis, eczema/dermatitis) and Meniere's disease. This suggests that physicians should pay more attention to the Meniere's patient's allergy history and consider allergy avoidance as part of their treatment plan.
Level of evidence
Mendelian Randomized (MR) studies are second only to randomized controlled trials in terms of the level of evidence.
目的在观察性研究中发现,过敏性疾病与梅尼埃病可能存在联系。然而,两者之间的潜在因果关系尚不清楚。方法从大规模全基因组关联研究中获得梅尼埃病和三种过敏性疾病(哮喘、过敏性鼻炎、湿疹/皮炎)的摘要级统计数据。研究采用反方差加权法作为主要测量方法,并辅以 MR-Egger 回归法和加权中位数法。结果逆方差加权法显示哮喘(P = 0.008,OR = 3.908,95% CI 1.424-10.724,adjust_p = 0.024)、过敏性鼻炎(p = 0.026,OR = 24.714,95% CI 1.479-412.827,adjust_p = 0.026)和湿疹/皮炎(p = 0.019,OR = 3725.954,95% CI 3.795 至 3658,399.580,adjust_p = 0.029)均对梅尼埃病有显著影响。反向孟德尔随机研究表明,梅尼埃病不会增加三种过敏性疾病的风险。结论我们的孟德尔随机分析支持三种过敏性疾病(哮喘、过敏性鼻炎、湿疹/皮炎)与美尼尔氏病之间存在正向因果关系。这表明,医生应更多地关注梅尼埃病患者的过敏史,并将避免过敏作为治疗计划的一部分。证据级别孟德尔随机(MR)研究的证据级别仅次于随机对照试验。
{"title":"Allergic diseases and Meniere's disease: a bidirectional Mendelian randomization","authors":"Hongru Qin, Meng Huang, Weiming Liang, Guojing Wu, Mengjia Tan, Junli Zhang, Wenyong Chen","doi":"10.1016/j.bjorl.2024.101472","DOIUrl":"10.1016/j.bjorl.2024.101472","url":null,"abstract":"<div><h3>Objectives</h3><p>Allergic diseases and Meniere's disease found to have a possible link in observational study. However, the potential causal relationship between the two is unclear. Therefore, we aimed to explore the causal relationship between allergic diseases and Meniere's disease using a new data analysis technique called bidirectional Mendelian randomization study.</p></div><div><h3>Method</h3><p>Summary-level statistics for Meniere's disease and three allergic diseases (asthma, allergic rhinitis, eczema/dermatitis) were obtained from large-scale genome-wide association studies. The inverse variance weighted method was used as the primary measure, supplemented by MR-Egger regression and the weighted median method. To ensure the reliability of the conclusions, Cochran's Q, MR-Egger intercept, MR-PRESSO test, leave-one-out test, and MR Steiger test were used.</p></div><div><h3>Results</h3><p>Inverse-variance weighted method showed asthma (<em>p</em> = 0.008, OR = 3.908, 95% CI 1.424–10.724, adjust_<em>p</em> = 0.024), allergic rhinitis (<em>p</em> = 0.026, OR = 24.714, 95% CI 1.479–412.827, adjust_<em>p</em> = 0.026) and eczema/dermatitis (<em>p</em> = 0.019, OR = 3725.954, 95% CI 3.795 to 3,658,399.580, adjust_<em>p</em> = 0.029) all had a significant effect on Meniere's disease. Reverse Mendelian randomization studies have shown that Meniere's disease does not increase the risk of three allergic diseases. Sensitivity analysis showed no horizontal pleiotropy and heterogeneity for each trait.</p></div><div><h3>Conclusion</h3><p>Our Mendelian randomization analysis supports a positive causal relationship between three allergic diseases (asthma, allergic rhinitis, eczema/dermatitis) and Meniere's disease. This suggests that physicians should pay more attention to the Meniere's patient's allergy history and consider allergy avoidance as part of their treatment plan.</p></div><div><h3>Level of evidence</h3><p>Mendelian Randomized (MR) studies are second only to randomized controlled trials in terms of the level of evidence.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 6","pages":"Article 101472"},"PeriodicalIF":1.7,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000879/pdfft?md5=06dc86df29055c912af06681f3e0f838&pid=1-s2.0-S1808869424000879-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.1016/j.bjorl.2024.101470
Roberta Seabra Venite , Leandro Pernambuco , Roberta Gonçalves da Silva , Suely Mayumi Motonaga Onofri
Objective
To report the process of translation and cross-cultural adaptation of theYale Pharyngeal Residue Severity Rating Scale into Brazilian Portuguese.
Methods
Methodological study approved by the Ethics Committee of the Institution (nº 5.166.256). The English original scale was translated into Brazilian Portuguese following suggested in the literature guidelines and recommendations after authorization from the authors of the original instrument, and involved the following reported steps of (1) Translation, (2) Synthesis of translations, (3) Determination of the applicability of the translated version 4) Back-translation, (5) Synthesis of the back-translated versions, and (6) Final synthesis. The translations and back-translations were performed by two bilingual translators. The research committee constituted three specialists who considered whether the linguistic, semantics, conceptual, idiomatic, and contextual equivalence of the translations and back-translations were. In Step 3, the raters consisted of three Speech-Language Pathologists and five ENT physicians divided into two subgroups (less than 5 years of professional expertise, and more than 5 years of professional expertise).
Results
Step 1 was carried out properly by the translators, in Step 2 the translated version was prepared after minor adjustments. In Step 3, the raters reported that they found no difficulties in applying the scale. The Cronbach's Alpha coefficient was 0.995, demonstrating high internal consistency of the instrument, and the analysis of the Intraclass Correlation Coefficient (ICC) among the eight raters was 0.994 with a confidence interval between 0.990 and 0.998, demonstrating excellent agreement, regardless of experience. The research committee judged the last to be adequate and not to require adjustments.
Conclusion
The Brazilian Portuguese version of theYale Pharyngeal Residue Severity Rating Scale is presented in this study.
This is a methodological study – No level of evidence.
{"title":"Translation and cross-cultural adaptation of the Yale Pharyngeal Residue Severity Rating Scale into Brazilian Portuguese","authors":"Roberta Seabra Venite , Leandro Pernambuco , Roberta Gonçalves da Silva , Suely Mayumi Motonaga Onofri","doi":"10.1016/j.bjorl.2024.101470","DOIUrl":"10.1016/j.bjorl.2024.101470","url":null,"abstract":"<div><h3>Objective</h3><p>To report the process of translation and cross-cultural adaptation of the<em>Yale Pharyngeal Residue Severity Rating Scale</em> into Brazilian Portuguese.</p></div><div><h3>Methods</h3><p>Methodological study approved by the Ethics Committee of the Institution (nº 5.166.256). The English original scale was translated into Brazilian Portuguese following suggested in the literature guidelines and recommendations after authorization from the authors of the original instrument, and involved the following reported steps of (1) Translation, (2) Synthesis of translations, (3) Determination of the applicability of the translated version 4) Back-translation, (5) Synthesis of the back-translated versions, and (6) Final synthesis. The translations and back-translations were performed by two bilingual translators. The research committee constituted three specialists who considered whether the linguistic, semantics, conceptual, idiomatic, and contextual equivalence of the translations and back-translations were. In Step 3, the raters consisted of three Speech-Language Pathologists and five ENT physicians divided into two subgroups (less than 5 years of professional expertise, and more than 5 years of professional expertise).</p></div><div><h3>Results</h3><p>Step 1 was carried out properly by the translators, in Step 2 the translated version was prepared after minor adjustments. In Step 3, the raters reported that they found no difficulties in applying the scale. The Cronbach's Alpha coefficient was 0.995, demonstrating high internal consistency of the instrument, and the analysis of the Intraclass Correlation Coefficient (ICC) among the eight raters was 0.994 with a confidence interval between 0.990 and 0.998, demonstrating excellent agreement, regardless of experience. The research committee judged the last to be adequate and not to require adjustments.</p></div><div><h3>Conclusion</h3><p>The Brazilian Portuguese version of the<em>Yale Pharyngeal Residue Severity Rating Scale</em> is presented in this study.</p><p>This is a methodological study – No level of evidence.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 5","pages":"Article 101470"},"PeriodicalIF":1.7,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000855/pdfft?md5=d7a4fb47494d688651c8609dfa536ff8&pid=1-s2.0-S1808869424000855-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141716692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-14DOI: 10.1016/j.bjorl.2024.101468
Leticia Andrade de Angelo, Fernando Linhares Pereira, Bruno Bernardo Duarte, Michel Burihan Cahali
Objectives
This study aims to review the current role of various ultrasonographic methods in the evaluation of the upper airway in patients with obstructive sleep apnea.
Methods
A literature review was performed on the medical databases: Pubmed, Web of Science, Scopus and Embase. After analyzing the available studies, six of them were selected for data extraction.
Results
All selected studies demonstrated that it is possible to use ultrasonography as a method of evaluating the upper airway. Studies with gray-scale ultrasound concluded that the lateral pharyngeal wall and tongue are thicker in patients with obstructive sleep apnea compared to non-apneic patients. Moreover, studies with tissue characterization ultrasound, nowadays called quantitative ultrasound, have identified unique features in obstructive sleep apnea patients: standardized backscatter ultrasonography demonstrated that this particular sound wave analysis is associated with the severity of obstructive sleep apnea. Ultrasonography with elastography shows that the electrical stimulus generated in the hypoglossal nerve results in greater stiffness on the side of the tongue that is stimulated; whereas studies show conflicting results regarding the evaluation of baseline tongue stiffness in obstructive sleep apnea patients compared to non-apneic subjects.
Conclusion
There is feasibility of different methods of ultrasonographic evaluation of the upper airway, with emphasis on ultrasonographic methods of tissue characterization, such as elastography, which proved to be a promising method of evaluating the mechanical properties of the muscles involved in the pathogenesis of obstructive sleep apnea and which require further studies for a better elucidation of its applicability.
本研究旨在回顾目前各种超声波检查方法在阻塞性睡眠呼吸暂停患者上气道评估中的作用:方法在以下医学数据库中进行了文献综述:Pubmed、Web of Science、Scopus 和 Embase。结果所有被选中的研究都表明,使用超声波检查作为评估上气道的方法是可行的。灰阶超声研究认为,与非呼吸暂停患者相比,阻塞性睡眠呼吸暂停患者的咽侧壁和舌部较厚。此外,利用组织特征超声波(现称为定量超声波)进行的研究发现了阻塞性睡眠呼吸暂停患者的独特特征:标准化背向散射超声波检查表明,这种特殊的声波分析与阻塞性睡眠呼吸暂停的严重程度有关。超声波弹性成像显示,舌下神经产生的电刺激会导致受刺激一侧的舌头更僵硬;而与非呼吸暂停受试者相比,研究显示阻塞性睡眠呼吸暂停患者舌头僵硬度基线的评估结果相互矛盾。结论不同的上气道超声波评估方法都是可行的,重点是超声波组织特征描述方法,如弹性成像,它被证明是评估阻塞性睡眠呼吸暂停发病机制中肌肉机械特性的一种有前途的方法,需要进一步研究以更好地阐明其适用性。
{"title":"Use of ultrasonography in the evaluation of patients with sleep apnea: a systematic review","authors":"Leticia Andrade de Angelo, Fernando Linhares Pereira, Bruno Bernardo Duarte, Michel Burihan Cahali","doi":"10.1016/j.bjorl.2024.101468","DOIUrl":"10.1016/j.bjorl.2024.101468","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to review the current role of various ultrasonographic methods in the evaluation of the upper airway in patients with obstructive sleep apnea.</p></div><div><h3>Methods</h3><p>A literature review was performed on the medical databases: Pubmed, Web of Science, Scopus and Embase. After analyzing the available studies, six of them were selected for data extraction.</p></div><div><h3>Results</h3><p>All selected studies demonstrated that it is possible to use ultrasonography as a method of evaluating the upper airway. Studies with gray-scale ultrasound concluded that the lateral pharyngeal wall and tongue are thicker in patients with obstructive sleep apnea compared to non-apneic patients. Moreover, studies with tissue characterization ultrasound, nowadays called quantitative ultrasound, have identified unique features in obstructive sleep apnea patients: standardized backscatter ultrasonography demonstrated that this particular sound wave analysis is associated with the severity of obstructive sleep apnea. Ultrasonography with elastography shows that the electrical stimulus generated in the hypoglossal nerve results in greater stiffness on the side of the tongue that is stimulated; whereas studies show conflicting results regarding the evaluation of baseline tongue stiffness in obstructive sleep apnea patients compared to non-apneic subjects.</p></div><div><h3>Conclusion</h3><p>There is feasibility of different methods of ultrasonographic evaluation of the upper airway, with emphasis on ultrasonographic methods of tissue characterization, such as elastography, which proved to be a promising method of evaluating the mechanical properties of the muscles involved in the pathogenesis of obstructive sleep apnea and which require further studies for a better elucidation of its applicability.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 6","pages":"Article 101468"},"PeriodicalIF":1.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000831/pdfft?md5=9f50accf3c6ec8feb0dac47bb673ae1a&pid=1-s2.0-S1808869424000831-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-14DOI: 10.1016/j.bjorl.2024.101469
Bárbara Duarte Salgueiro , Neemias Santos Carneiro , Hemiliy Izabel Alves Neves , Isabel Saorin Conte , Rita Carolina Pozzer Krumenauer Padoin , Renata Loss Drummond , Marcelo Neves Lubianca , José Faibes Lubianca Neto
Objectives
Percutaneous Vocal Fold Lateralization (PVFL) consists of external fixation with non-absorbable percutaneous suture of the vocal fold in a lateral position, under direct glottic visualization. The objective of this study is to determine the effectiveness of PVFL in a university pediatric hospital, as well as to describe the potential risks and complications of the surgery.
Methods
Retrospective cohort study, with data collected from electronic medical records. The study was approved by the Research Ethics Committee of the institution. Surgeries were performed with the modified Lichentenberg technique and data, and outcomes were analyzed.
Results
Six patients with Bilateral Vocal Fold Paralysis who underwent Percutaneous Vocal Fold Lateralization were evaluated. Three patients were male. The age at diagnosis ranged from 2 to 132 days (mean 10.5 days). The reason for investigating the upper airway was the presence of increased work of breathing and stridor. Five patients had a favorable clinical evolution, with spontaneous ventilation in room air and absence of stridor or ventilatory effort, without the need for tracheostomy. Surgical results in this series corroborate the findings of other similar cohorts, which showed Percutaneous Vocal Fold Lateralization as a safe and effective procedure in avoiding tracheostomy or allowing decannulation in children with Bilateral Vocal Fold Paralysis.
Conclusions
PVFL seems to be a safe and effective procedure, but it has morbidity, due to immediate, and probably late, non-serious complications. Studies with a larger number of patients, with longer follow-up and using a controlled and randomized clinical design are needed to establish the role of PVFL in the treatment of BVFP in newborns and infants.
{"title":"Percutaneous Vocal Fold Lateralization in children — a case series of a Brazilian tertiary pediatric hospital (pediatric vocal fold lateralization cases in a Brazilian hospital)","authors":"Bárbara Duarte Salgueiro , Neemias Santos Carneiro , Hemiliy Izabel Alves Neves , Isabel Saorin Conte , Rita Carolina Pozzer Krumenauer Padoin , Renata Loss Drummond , Marcelo Neves Lubianca , José Faibes Lubianca Neto","doi":"10.1016/j.bjorl.2024.101469","DOIUrl":"10.1016/j.bjorl.2024.101469","url":null,"abstract":"<div><h3>Objectives</h3><p>Percutaneous Vocal Fold Lateralization (PVFL) consists of external fixation with non-absorbable percutaneous suture of the vocal fold in a lateral position, under direct glottic visualization. The objective of this study is to determine the effectiveness of PVFL in a university pediatric hospital, as well as to describe the potential risks and complications of the surgery.</p></div><div><h3>Methods</h3><p>Retrospective cohort study, with data collected from electronic medical records. The study was approved by the Research Ethics Committee of the institution. Surgeries were performed with the modified Lichentenberg technique and data, and outcomes were analyzed.</p></div><div><h3>Results</h3><p>Six patients with Bilateral Vocal Fold Paralysis who underwent Percutaneous Vocal Fold Lateralization were evaluated. Three patients were male. The age at diagnosis ranged from 2 to 132 days (mean 10.5 days). The reason for investigating the upper airway was the presence of increased work of breathing and stridor. Five patients had a favorable clinical evolution, with spontaneous ventilation in room air and absence of stridor or ventilatory effort, without the need for tracheostomy. Surgical results in this series corroborate the findings of other similar cohorts, which showed Percutaneous Vocal Fold Lateralization as a safe and effective procedure in avoiding tracheostomy or allowing decannulation in children with Bilateral Vocal Fold Paralysis.</p></div><div><h3>Conclusions</h3><p>PVFL seems to be a safe and effective procedure, but it has morbidity, due to immediate, and probably late, non-serious complications. Studies with a larger number of patients, with longer follow-up and using a controlled and randomized clinical design are needed to establish the role of PVFL in the treatment of BVFP in newborns and infants.</p></div><div><h3>Levels of evidence</h3><p>Level 4 (step 4).</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 5","pages":"Article 101469"},"PeriodicalIF":1.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000843/pdfft?md5=f78a2c3403864d4f84891bfe5d6cb23a&pid=1-s2.0-S1808869424000843-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141691819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the most common sensory impairments in the elderly is age-related hearing loss, and individuals with this condition have a higher risk of mild cognitive impairment than the overall aged population. The purpose of this study was to conduct a systematic review of the literature in order to evaluate the evidence supporting the hypothesis that mild cognitive impairment may be developed in patients with age-related hearing loss.
Methods
The PRISMA principles were followed when searching the databases of the China Knowledge Network, Wanfang, China Biomedical Literature Database, Pub Med, Cochrane Library, Embase, and Web of Science. Two investigators independently carried out the quality assessment, data extraction, and literature review of the eligible studies. Stata 17.0 was used to finish the statistical analysis and descriptive results.
Results
A total of 13 articles containing 2,222,036 individuals who were evaluated for demographic traits, factors associated with age-related hearing loss, vascular neurologic factors, and psychological factors were included after 2166 search records were found in the database. In patients with age-related hearing loss, eleven factors were found to be risk factors for the development of mild cognitive impairment: age (OR = 1.63; 95% CI 1.09–2.43), male (OR = 1.29; 95% CI 1.14–1.47), degree of hearing loss (OR = 1.35; 95% CI 1.03–1.75), not wearing hearing aids (OR = 1.56; 95% CI 1.37–1.79), cerebrovascular disease (OR = 1.41; 95% CI 1.17–1.69), cardiovascular disease (OR = 1.29; 95% CI 1.07–1.55), diabetes mellitus (OR = 1.28; 95% CI 1.20–1.35), head injury (OR = 1.22; 95% CI 1.13–1.33), alcohol consumption (OR = 1.28; 95% CI 1.14–1.43), and tobacco use (OR = 1.19; 95% CI 1.14–1.25), and depression (OR = 1.63; 95% CI 1.47–1.81).
Conclusion
Caregivers can customize care strategies to decrease the occurrence of mild cognitive impairment in elderly deaf patients by considering demographic traits, factors associated with age-related hearing loss, vascular-neurologic factors, and psychological factors.
目的老年性听力损失是老年人最常见的感官障碍之一,与整体老年人群相比,患有老年性听力损失的人患轻度认知障碍的风险更高。本研究旨在对文献进行系统性回顾,以评估支持老年性听力损失患者可能出现轻度认知障碍这一假设的证据。方法在检索中国知网、万方数据库、中国生物医学文献数据库、Pub Med、Cochrane Library、Embase 和 Web of Science 等数据库时遵循 PRISMA 原则。两名研究人员独立对符合条件的研究进行了质量评估、数据提取和文献综述。结果 在数据库中找到 2166 条检索记录后,共纳入 13 篇文章,包含 2,222,036 人的人口统计学特征、老年性听力损失相关因素、血管神经因素和心理因素的评估。在老年性听力损失患者中,发现有 11 个因素是轻度认知障碍发生的危险因素:年龄(OR = 1.63;95% CI 1.09-2.43)、男性(OR = 1.29;95% CI 1.14-1.47)、听力损失程度(OR = 1.35;95% CI 1.03-1.75)、未佩戴助听器(OR = 1.56;95% CI 1.37-1.79)、脑血管疾病(OR = 1.41;95% CI 1.17-1.69)、心血管疾病(OR = 1.29;95% CI 1.07-1.55)、糖尿病(OR = 1.28;95% CI 1.20-1.35)、头部损伤(OR = 1.22;95% CI 1.13-1.33)、饮酒(OR = 1.28;95% CI 1.14-1.43)和吸烟(OR = 1.19;95% CI 1.14-1.25)以及抑郁症(OR = 1.63;95% CI 1.47-1.81)。结论护理人员可以通过考虑人口统计学特征、与老年性听力损失相关的因素、血管神经因素和心理因素来定制护理策略,以减少老年耳聋患者轻度认知障碍的发生。
{"title":"Risk factors for mild cognitive impairment in patients with age-related hearing loss: a meta-analysis","authors":"Chenxingzi Wu, Wenjuan Wang, Ruilin Li, Yuhong Su, Huiling Lv, Shuhong Qin, Zhanhang Zheng","doi":"10.1016/j.bjorl.2024.101467","DOIUrl":"10.1016/j.bjorl.2024.101467","url":null,"abstract":"<div><h3>Objectives</h3><p>One of the most common sensory impairments in the elderly is age-related hearing loss, and individuals with this condition have a higher risk of mild cognitive impairment than the overall aged population. The purpose of this study was to conduct a systematic review of the literature in order to evaluate the evidence supporting the hypothesis that mild cognitive impairment may be developed in patients with age-related hearing loss.</p></div><div><h3>Methods</h3><p>The PRISMA principles were followed when searching the databases of the China Knowledge Network, Wanfang, China Biomedical Literature Database, Pub Med, Cochrane Library, Embase, and Web of Science. Two investigators independently carried out the quality assessment, data extraction, and literature review of the eligible studies. Stata 17.0 was used to finish the statistical analysis and descriptive results.</p></div><div><h3>Results</h3><p>A total of 13 articles containing 2,222,036 individuals who were evaluated for demographic traits, factors associated with age-related hearing loss, vascular neurologic factors, and psychological factors were included after 2166 search records were found in the database. In patients with age-related hearing loss, eleven factors were found to be risk factors for the development of mild cognitive impairment: age (OR = 1.63; 95% CI 1.09–2.43), male (OR = 1.29; 95% CI 1.14–1.47), degree of hearing loss (OR = 1.35; 95% CI 1.03–1.75), not wearing hearing aids (OR = 1.56; 95% CI 1.37–1.79), cerebrovascular disease (OR = 1.41; 95% CI 1.17–1.69), cardiovascular disease (OR = 1.29; 95% CI 1.07–1.55), diabetes mellitus (OR = 1.28; 95% CI 1.20–1.35), head injury (OR = 1.22; 95% CI 1.13–1.33), alcohol consumption (OR = 1.28; 95% CI 1.14–1.43), and tobacco use (OR = 1.19; 95% CI 1.14–1.25), and depression (OR = 1.63; 95% CI 1.47–1.81).</p></div><div><h3>Conclusion</h3><p>Caregivers can customize care strategies to decrease the occurrence of mild cognitive impairment in elderly deaf patients by considering demographic traits, factors associated with age-related hearing loss, vascular-neurologic factors, and psychological factors.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 6","pages":"Article 101467"},"PeriodicalIF":1.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S180886942400082X/pdfft?md5=e3fff2705b1e4431d7957c4900dc1005&pid=1-s2.0-S180886942400082X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.1016/j.bjorl.2024.101466
Nesha Rajendram , Masaany Mansor , Norazila Abdul Rahim , Mohd Zukiflee Abu Bakar , Muhammad Arif Sobani
{"title":"Office based non-invasive diagnostic technique for acquired tracheoesophageal fistula","authors":"Nesha Rajendram , Masaany Mansor , Norazila Abdul Rahim , Mohd Zukiflee Abu Bakar , Muhammad Arif Sobani","doi":"10.1016/j.bjorl.2024.101466","DOIUrl":"10.1016/j.bjorl.2024.101466","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 5","pages":"Article 101466"},"PeriodicalIF":1.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000818/pdfft?md5=abcd8360116020c4bf744b60db1e8f9f&pid=1-s2.0-S1808869424000818-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}