Brazilian Journal of Otorhinolaryngology最新文献

{"title":"Identification of core gene in chronic rhinosinusitis with nasal polyps and correlations with inflammation-related genes","authors":"Jingpu Yang ,&nbsp;Chang Liu ,&nbsp;Jinzhang Cheng ,&nbsp;Yunmeng Wang ,&nbsp;Zonggui Wang ,&nbsp;Wei Zhong","doi":"10.1016/j.bjorl.2024.101410","DOIUrl":"10.1016/j.bjorl.2024.101410","url":null,"abstract":"<div><h3>Objective</h3><p>Our aim in this study is to identify the core genes of chronic rhinosinusitis with nasal polyps and analyze the correlations between it and inflammation-related genes.</p></div><div><h3>Methods</h3><p>GSE72713 dataset containing gene expression data of ECRSwNP, nonECRSwNP and healthy samples was obtained from Gene Expression Omnibus (GEO) and filtered by limma to identify DEGs among three groups, then the functions and correlated pathways of DEGs were analyzed using GO and KEGG. The core DEGs were selected by the intersection of DEGs and the PPI network was constructed via STRING. The correlations between the expression levels of CRSwNP core gene and inflammation-related genes were analyzed via the Mann-Whitney <em>U</em> test.</p></div><div><h3>Results</h3><p>The DEGs among ECRSwNP, nonECRSwNP, and CTRL were filtered respectively, and enrichment analysis showed they were associated with olfaction and/or immune responses. The PPI network was constructed by 7 core DEGs obtained via the intersection among three groups, and ALOX15 was confirmed as the core gene in the network. Subsequently, the correlations between the expression levels of ALOX15 and inflammation-related genes were illustrated.</p></div><div><h3>Conclusion</h3><p>In this study, the core gene ALOX15 was selected from the DEGs among ECRSwNP, nonECRSwNP, and CTRL. IL5, IL1RL1, and IL1RAP were found to exhibit a significant positive correlation with ALOX15.</p></div><div><h3>Level of Evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 3","pages":"Article 101410"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000259/pdfft?md5=9683e7d9e2a10845d8ae47076f3bfe2d&pid=1-s2.0-S1808869424000259-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic rhinosinusitis with nasal polyps: changing expectations","authors":"Otavio B. Piltcher","doi":"10.1016/j.bjorl.2024.101415","DOIUrl":"https://doi.org/10.1016/j.bjorl.2024.101415","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 2","pages":"Article 101415"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000302/pdfft?md5=e36fda10b6acefca096d807e1c5da8e3&pid=1-s2.0-S1808869424000302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asymmetry of the anterior ethmoidal artery in relation to the anterior skull base: a population-based study of 500 arteries","authors":"Bernard Beraldin ,&nbsp;Gustavo Rassier Isolan ,&nbsp;Lucas Rodrigues Mostardeiro ,&nbsp;Vagner Antonio Rodrigues Silva ,&nbsp;Joel Lavinsky","doi":"10.1016/j.bjorl.2024.101412","DOIUrl":"10.1016/j.bjorl.2024.101412","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze variability in the distance between the Anterior Ethmoidal Artery (AEA) and the anterior Skull Base (SB), as well as the frequency of lateral asymmetry in a Latin American population using computed tomography.</p></div><div><h3>Methods</h3><p>A total of 250 computed tomography scans of paranasal sinuses in coronal reconstruction (500 AEAs) were analyzed. After determining the image with the best anatomical view of the artery, the distance between its midpoint and the ethmoidal roof was measured, and the images were independently interpreted by 2 physicians.</p></div><div><h3>Results</h3><p>Of the 500 AEAs, 279 (55.8%) adhered to or passed through the SB at a distance of 0<!--> <!-->mm. A total of 221 AEAs (44.2%) were at some distance from the SB, of which 107 (48.4%) were on the right side, ranging from 1.18 to 6.75<!--> <!-->mm, and 114 (51.5%) were on the left side, ranging from 1.15 to 6.04<!--> <!-->mm. The overall mean distance between the AEA and SB was 1.22 (SD<!--> <!-->=<!--> <!-->1.57) mm, increasing to 2.77 (SD<!--> <!-->=<!--> <!-->1.14) when the arteries adhered to the SB were excluded. Seventy-six individuals (30.4%) had a lateral distance variation &gt; 1<!--> <!-->mm.</p></div><div><h3>Conclusion</h3><p>Our study includes the largest sample of AEA analyzed with computed tomography scans of paranasal sinuses. There was some distance between the AEA and SB in almost half the patients, and we found a high rate of lateral variability &gt;1<!--> <!-->mm.</p></div><div><h3>Level of evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 3","pages":"Article 101412"},"PeriodicalIF":2.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000272/pdfft?md5=d1dbfed6b9c49ca5f714ea51db26a27f&pid=1-s2.0-S1808869424000272-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NKX2-1 gene is targeted by H19 lncRNA and is found to be overexpressed in benign nodular goiter tissues","authors":"Seyed-Morteza Javadirad","doi":"10.1016/j.bjorl.2024.101409","DOIUrl":"https://doi.org/10.1016/j.bjorl.2024.101409","url":null,"abstract":"<div><h3>Objective</h3><p>Nodular goiter may increase the risk of thyroid cancer, but the genetic factors contributing to nodular goiter are not well understood. There is an overexpression of H19 lncRNA in goiter tissue and its target remains unknown. In this study, we attempted to identify a new target for H19 in the context of goiter development.</p></div><div><h3>Methods</h3><p>Using interaction energy calculations, the interaction between NKX2-1 mRNA and H19 lncRNA was examined. Putative microRNAs were found at the H19 lncRNA target site with the highest affinity for NKX2-1. RNAseq data was analyzed to determine the tissue specificity of gene expression. Samples were taken from 18 goiter and 18 normal tissues during thyroidectomy. The expression of NKX2-1 was determined by RT-qPCR using specific primers.</p></div><div><h3>Results</h3><p>The interaction between NKX2-1 and H19 was characterized by six local base-pairing connections, with a maximum energy of −20.56 kcal/moL. Specifically, the sequence that displayed the highest affinity for binding with H19 overlapped with the binding site of has-miR-1827 to NKX2-1. It was found that NKX2-1 is exclusively co-expressed with H19 in normal thyroid tissue. As compared to adjacent normal tissues, nodular goiter tissues have a significant overexpression of NKX2-1 (relative expression = 1.195, <em>p</em> =  0.038).</p></div><div><h3>Conclusion</h3><p>NKX2-1 has been identified as the putative target of H19 lncRNA, which is overexpressed in nodular goiter tissues significantly.</p></div><div><h3>Level of Evidence</h3><p>4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 4","pages":"Article 101409"},"PeriodicalIF":2.2,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000247/pdfft?md5=3a426522b542632b12251e1fe25828a6&pid=1-s2.0-S1808869424000247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parapharyngeal and retropharyngeal infections in children: Kawasaki disease needs vigilance","authors":"Jia Liu ,&nbsp;Shui-Hong Zhou","doi":"10.1016/j.bjorl.2024.101405","DOIUrl":"10.1016/j.bjorl.2024.101405","url":null,"abstract":"<div><h3>Objective</h3><p>Kawasaki Disease (KD) may mimic Parapharyngeal (PPI) and Retropharyngeal Infections (RPI), leading to misdiagnosis as Deep Neck Infections (DNIs). The treatment plans for the two diseases are different, and delayed treatment can lead to serious complications. Therefore, prompt diagnosis and management are necessary. This study was performed to evaluate the clinical features of KD mimicking DNIs and explore the treatment options.</p></div><div><h3>Methods</h3><p>Children with cellulitis or abscess in parapharyngeal or retropharyngeal space in neck CT were included in this study. The medical records of enrolled children were retrospectively reviewed.</p></div><div><h3>Results</h3><p>In total, 56 children were diagnosed with PPI or/and RPI. Twenty-two (39.3%) participants were eventually diagnosed with KD, and 34 (60.7%) were diagnosed with DNIs. Compared with the DNIs group, the KD group had a higher body temperature (<em>p</em> <!-->=<!--> <!-->0.007), and higher levels of AST (<em>p</em> <!-->=<!--> <!-->0.040), ALT (<em>p</em> <!-->=<!--> <!-->0.027), and ESR (<em>p</em> <!-->=<!--> <!-->0.030). Deep cervical cellulitis (<em>p</em> <!-->=<!--> <!-->0.005) were more common in the KD group. However, deep neck abscess often occurred in the DNIs group (<em>p</em> <!-->=<!--> <!-->0.002), with parapharyngeal abscess being the most common type of abscess (<em>p</em> <!-->=<!--> <!-->0.004). The KD mimicking DNIs cases did not respond to antibiotic treatment, but symptoms significantly improved after the use of Immunoglobulin (IVIG) and aspirin.</p></div><div><h3>Conclusion</h3><p>Children with KD may exhibit retropharyngeal or parapharyngeal inflammation in the early stages. KD should be considered a differential diagnosis for children with DNIs, high fever, and no response to antibiotic therapy. Surgery in KD mimicking deep neck abscess requires caution.</p></div><div><h3>Level of Evidence</h3><p>I.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 3","pages":"Article 101405"},"PeriodicalIF":2.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S180886942400020X/pdfft?md5=73de01322858d678c1792dc2574ecc4b&pid=1-s2.0-S180886942400020X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139949681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified extracorporeal septoplasty: prospective study","authors":"Raphaella de Oliveira Migliavacca ,&nbsp;Michelle Lavinsky ,&nbsp;Olívia Egger de Souza ,&nbsp;Eduardo Priesnitz Friedrich ,&nbsp;Otávio Augusto Gonçalves Dias Cionek ,&nbsp;Leonardo Ferreira Subda ,&nbsp;Bárbara Luiza Bernardi","doi":"10.1016/j.bjorl.2024.101398","DOIUrl":"10.1016/j.bjorl.2024.101398","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to evaluate quality-of-life and satisfaction outcomes in patients undergoing the MES using the Portuguese version of the Nasal Obstruction Symptom Evaluation (NOSE-p) and Rhinoplasty Outcome Evaluation (ROE), and also to evaluate the frequency of possible complications of this technique.</p></div><div><h3>Methods</h3><p>We conducted a single-center prospective study with patients who had the indication for MES, from May 2016 to September 2020 at the Facial Plastic Surgery Clinic of Otolaryngology Department of the Hospital de Clinicas de Porto Alegre. The primary outcome was the relative postoperative change in NOSE-p. Secondary outcome was the variation in ROE, a validated quality-of-life questionnaire for rhinoplasty patients.</p></div><div><h3>Results</h3><p>Of the 31 patients submitted to extracorporeal septorhinoplasty who were evaluated, twenty-seven patients were included. Preoperative and postoperative NOSE-p scale scores were 65.2 ± 29.9 and 23.5 ± 26.7, respectively (mean differences of 42.04; [95% CI 27.35–56.73]; <em>p</em> &lt;  0.0001). Pre and postoperative ROE scores were 38.3 ± 24.3 vs. 67.29 ± 29.7, respectively (mean differences of −29.02; [95% CI −40.5 to −17.5]; <em>p</em> =  0.0001). Residual septal deviation was verified in 2 patients (7.4%).</p></div><div><h3>Conclusion</h3><p>Most of the patients submitted to modified extracorporeal septoplasty had a significant improvement in quality of life scores of nasal obstruction, with good aesthetical outcomes and low indices of postoperative complications.</p></div><div><h3>Level of evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 3","pages":"Article 101398"},"PeriodicalIF":2.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000132/pdfft?md5=aefc7e31bfedda6b5288de2ef6f7cec6&pid=1-s2.0-S1808869424000132-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139956434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Squamous cell carcinoma arising from a cholesteatoma of the maxillary sinus: a case report⋆","authors":"Tae-Gyun Kim,&nbsp;Chang-Ho Whangbo,&nbsp;Jae-Ho Yoo,&nbsp;Hee-Jun Park,&nbsp;Sang-Yen Geum,&nbsp;Seung-Heon Shin,&nbsp;Mi Kyung Ye","doi":"10.1016/j.bjorl.2024.101408","DOIUrl":"10.1016/j.bjorl.2024.101408","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 3","pages":"Article 101408"},"PeriodicalIF":2.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000235/pdfft?md5=b79586854121f906e6f502df9785d313&pid=1-s2.0-S1808869424000235-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139949679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Position paper of diagnosis and treatment of post-extubation laryngitis in a multidisciplinary expert-based opinion","authors":"Débora Bressan Pazinatto ,&nbsp;Rebecca Maunsell ,&nbsp;Melissa Ameloti Gomes Avelino ,&nbsp;Jose Faibes Lubianca Neto ,&nbsp;Cláudia Schweiger ,&nbsp;Jamil Pedro de Siqueira Caldas ,&nbsp;Marcelo Barciela Brandão ,&nbsp;Paula Pires de Souza ,&nbsp;Fernanda Aparecida de Oliveira Peixoto ,&nbsp;Claudia Pires Ricachinevsky ,&nbsp;Rita C. Silveira ,&nbsp;Cinara Andreolio ,&nbsp;Carolina Sponchiado Miura ,&nbsp;Daniele da Silva Jordan Volpe ,&nbsp;Walusa Assad Gonçalves Ferri ,&nbsp;Fabiano Bleggi Gavazzoni ,&nbsp;Paulo Ramos David João ,&nbsp;Silmara Aparecida Possas ,&nbsp;Carlos Takahiro Chone","doi":"10.1016/j.bjorl.2024.101401","DOIUrl":"10.1016/j.bjorl.2024.101401","url":null,"abstract":"<div><h3>Objectives</h3><p>To make recommendations on the diagnosis and treatment of post-extubation laryngitis (PEL) in children with or without other comorbidities.</p></div><div><h3>Methods</h3><p>A three-iterative modified Delphi method was applied. Specialists were recruited representing pediatric otolaryngologists, pediatric and neonatal intensivists. Questions and statements approached topics encompassing definition, diagnosis, endoscopic airway evaluation, risk factors, comorbidities, management, and follow-up. A consensus was defined as a supermajority &gt;70%.</p></div><div><h3>Results</h3><p>Stridor was considered the most frequent symptom and airway endoscopy was recommended for definitive diagnosis. Gastroesophageal reflux and previous history of intubation were considered risk factors. Specific length of intubation did not achieve a consensus as a risk factor. Systemic corticosteroids should be part of the medical treatment and dexamethasone was the drug of choice. No consensus was achieved regarding dosage of corticosteroids, although endoscopic findings help defining dosage and length of treatment. Non-invasive ventilation, laryngeal rest, and use of comfort sedation scales were recommended. Indications for microlaryngoscopy and bronchoscopy under anesthesia were symptoms progression or failure to improve after the first 72-h of medical treatment post-extubation, after two failed extubations, and/or suspicion of severe lesions on flexible fiberoptic laryngoscopy.</p></div><div><h3>Conclusions</h3><p>Management of post-extubation laryngitis is challenging and can be facilitated by a multidisciplinary approach. Airway endoscopy is mandatory and impacts decision-making, although there is no consensus regarding dosage and length of treatment.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 3","pages":"Article 101401"},"PeriodicalIF":2.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000168/pdfft?md5=3c23be883b01b0590d22cdf9236f17ff&pid=1-s2.0-S1808869424000168-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139949609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-traditional endoscopic approach to laryngeal schwannoma","authors":"Petru Gurău","doi":"10.1016/j.bjorl.2024.101400","DOIUrl":"10.1016/j.bjorl.2024.101400","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 3","pages":"Article 101400"},"PeriodicalIF":2.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000156/pdfft?md5=f7302a1b2c197d92aaf37a5c226237e8&pid=1-s2.0-S1808869424000156-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139949680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New variants of ALMS1 gene and familial Alström syndrome case series","authors":"Isabela Carvalho de Queiroz,&nbsp;Natália Carasek,&nbsp;Luiza Costa Villela Ferreira,&nbsp;Lucas Alves Teixeira Oliveira,&nbsp;Fernando Massa Correia,&nbsp;Thaís Gomes Abrahão Elias,&nbsp;Fayez Bahmad Jr","doi":"10.1016/j.bjorl.2024.101402","DOIUrl":"10.1016/j.bjorl.2024.101402","url":null,"abstract":"<div><h3>Objectives</h3><p>To report two new variants of ALMS1 gene and to discuss the audiological evolution and clinical phenotype in two pairs of siblings with Alström syndrome.</p></div><div><h3>Report</h3><p>This paper is a multi-disciplinary diagnostic evaluation, with genetic and audiological analysis that aims to report two new variants of the ALMS1 gene and to discuss the audiological evolution and clinical phenotype in a case series of patients with familial Alström syndrome. Therefore, we describe 4 cases presenting a complete audiometric profile of two pairs of unrelated siblings, to provide a better understanding of this very rare disease. Additionally, the present study identified two heterozygous mutations in the ALMS1 gene.</p></div><div><h3>Conclusion</h3><p>This Clinical Capsule Report highlights the importance of audiological monitoring throughout the development of patients with Alström syndrome. The two variants found were not previously reported in the literature, which expands the spectrum of ALMS1 variants in Alström syndrome.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"90 3","pages":"Article 101402"},"PeriodicalIF":2.2,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S180886942400017X/pdfft?md5=4aa8cc8fb33f3d20138b38bf54bed606&pid=1-s2.0-S180886942400017X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139949989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}