Brazilian Journal of Otorhinolaryngology最新文献

{"title":"Oral and oropharyngeal mucosal lesions: clinical-epidemiological study of patients attended at a reference center for infectious diseases","authors":"Clarissa Souza Mota Reis ,&nbsp;João Gustavo Corrêa Reis ,&nbsp;Fátima Conceição-Silva ,&nbsp;Cláudia Maria Valete","doi":"10.1016/j.bjorl.2024.101396","DOIUrl":"10.1016/j.bjorl.2024.101396","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the prevalence, epidemiological profile, and clinical characteristics of Oral or Oropharyngeal Mucosal Lesions (OOPML) in patients attended at the Otorhinolaryngology Service of the Evandro Chagas National Institute of Infectious Diseases (INI-FIOCRUZ) from 2005 to 2017.</p></div><div><h3>Methods</h3><p>Statistical analysis of descriptive data from medical records (gender, age, education level, skin color, origin, smoking, alcoholism, HIV co-infection, time of disease evolution, first symptom, and OOPML location) was performed.</p></div><div><h3>Results</h3><p>Of 7551 patients attended at the service, 620 (8.2%) were included in the study. OOPML were classified into developmental anomalies (n = 3), infectious diseases (non-granulomatous n = 220; granulomatous n = 155), autoimmune diseases (n = 24), neoplasms (benign n = 13; malignant, n = 103), and unclassified epithelial/soft tissue diseases (n = 102). OOPML of infectious diseases (60.5%) and neoplasms (18.7%) were the most frequent. The predominant demographics of patients with OOPML were: males (63.5%), white (53.5%), and those in the fifth to sixth decades of life (43.3%). Local pain (18.1%) and odynophagia (15%) were the most reported first symptoms, and the most frequent OOPML sites were the palatine tonsil (28.5%), hard palate (22.7%), and tongue (20.3%). The median evolution time was three months.</p></div><div><h3>Conclusions</h3><p>Infectious OOPML were the most frequent, as expected in a reference center for infectious diseases, and thus, they are likely to be less frequent in general care and/or dental services. Underreporting of OOPML is possible, as oral/oropharyngeal examination is often not included in the routine medical examination. Oral cavity/oropharynx examination should be performed by specialists, such as dentists and otorhinolaryngologists, who have the expertise in identifying OOPML, even in incipient/asymptomatic cases. Given the numerous diseases in which OOPML can present, diagnosis could be facilitated by multidisciplinary teams, potentially enabling the early treatment of diseases, and thus, reduce morbidity and improve prognosis. The use of standardized medical records for oral/oropharyngeal systematic examination could provide relevant tools for differential diagnoses and information for new clinical-epidemiological studies.</p></div><div><h3>Level of evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000119/pdfft?md5=42eb118cb2b9d137f5543cac42140625&pid=1-s2.0-S1808869424000119-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brazilian guideline for the use of immunobiologicals in chronic rhinosinusitis with nasal polyps ‒ 2024 update","authors":"Wilma T. Anselmo-Lima ,&nbsp;Fabrizio R. Romano ,&nbsp;Edwin Tamashiro ,&nbsp;Renato Roithmann ,&nbsp;Vanessa R.P. Dinarte ,&nbsp;Otavio B. Piltcher ,&nbsp;Marcel M. Miyake ,&nbsp;Marco A. Fornazieri ,&nbsp;Marcio Nakanishi ,&nbsp;Thiago F.P. Bezerra ,&nbsp;Ricardo L.L. Dolci ,&nbsp;João F. Mello Jr ,&nbsp;Marcus M. Lessa ,&nbsp;Richard L. Voegels ,&nbsp;Eduardo M. Kosugi ,&nbsp;Eulalia Sakano ,&nbsp;Fabiana C.P. Valera","doi":"10.1016/j.bjorl.2024.101394","DOIUrl":"10.1016/j.bjorl.2024.101394","url":null,"abstract":"<div><h3>Introduction</h3><p>Biologics targeting type 2 inflammation have revolutionized the way we treat patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Particularly in severe and difficult-to-control cases, these drugs have provided a new reality for these patients, allowing for the effective and safe treatment of extensive diseases that were not completely managed with the typical strategy of surgery and topical medications.</p></div><div><h3>Objectives</h3><p>The experience achieved with the approval of these medications by ANVISA for use in CRSwNP and the knowledge obtained regarding outcomes, adverse effects, and the ideal patient profile prompted the update of the previously published guideline, with a detailed review of the most recent scientific literature, the personal experiences of experts, and the adaptation to the reality of the Brazilian healthcare system, both public and private.</p></div><div><h3>Results</h3><p>We proposed a new eligibility criterion for biologics in patients with CRSwNP based on four pillars of indication: the impact of the disease on the patient’s life, whether in the presence of specific symptoms or in overall quality of life; the extent of sinonasal disease; the presence of type 2 comorbidities, considering other associated diseases that may also benefit from anti-T2 biologics, and the presence of biomarkers to define type 2 inflammation, especially those associated with worse disease prognoses.</p></div><div><h3>Conclusions</h3><p>This innovative and pioneering method has two major advantages. First, it ensures a comprehensive evaluation of patients; second, it is flexible, as advancements in our understanding of the disease and changes in cost-effectiveness can be addressed by simply adjusting the required score for indication, without the need to modify the entire evaluation scheme.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000090/pdfft?md5=97d7aec3717eefb763a362c05b9c33a5&pid=1-s2.0-S1808869424000090-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139647082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anlotinib suppressed tumor cell proliferation and migration in hypopharyngeal carcinoma","authors":"Hao Song ,&nbsp;Qing Song ,&nbsp;Xiangkun Zhao ,&nbsp;Yuteng Yang ,&nbsp;Yakui Mou ,&nbsp;Yumei Li ,&nbsp;Xicheng Song","doi":"10.1016/j.bjorl.2024.101397","DOIUrl":"10.1016/j.bjorl.2024.101397","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this study is to study the in-vitro effects of multitarget inhibitor anlotinib on hypopharyngeal cancer cell proliferation and cell migration, and the underlying mechanism, which will provide new drug choices for hypopharyngeal cancer treatment.</p></div><div><h3>Methods</h3><p>The Hypopharyngeal cancer Fadu cells were treated with anlotinib at a concentration of 0, 5, and 10 μmoL/L, respectively. Cell counting kit-8 and the colony-forming assay were used to detect the inhibition of cell proliferation. Wound-healing assay and transwell assay were used to detect the migration and invasion ability of cells. Flow cytometry was used to detect the effects of anlotinib on cell cycle and apoptosis. RT-qPCR and Western blot were used to measure gene expression levels.</p></div><div><h3>Results</h3><p>CCK-8 and colony-forming assay showed that anlotinib could significantly inhibit cell proliferative activity. Wound-healing assay and transwell assay showed that anlotinib could inhibit cell migration and scratch. These results showed that anlotinib has obvious antitumor activity. Flow cell cycle experiment showed that anlotinib could promote Fadu cell apoptosis and block the G2/M phase for inhibiting cell proliferation. In addition, anlotinib decreased the expression of HIF-1α.</p></div><div><h3>Conclusions</h3><p>Anlotinib has an excellent suppressing effect on the proliferation, migration, and invasion of hypopharyngeal cancer Fadu cells in-vitro. Moreover, it can play an anti-tumor role through blocking cell cycle G2/M and promoting apoptosis, which may be related to the decrease of HIF-1a expression. Our study would provide a potential treatment method for patients with hypopharyngeal cancer.</p></div><div><h3>Level of evidence</h3><p>Level 3.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000120/pdfft?md5=3c80082aaec3249e3486764da20c0d47&pid=1-s2.0-S1808869424000120-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139580867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin-G4 laryngitis with co-existing Peyronie’s disease","authors":"Shivanchan Rajmohan ,&nbsp;Chuanyu Gao ,&nbsp;Kajaanan Rajmohan ,&nbsp;Shivun Khosla ,&nbsp;Lisa Pitkin","doi":"10.1016/j.bjorl.2024.101395","DOIUrl":"10.1016/j.bjorl.2024.101395","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000107/pdfft?md5=8de2f5132ecf18621a4997019ee010b7&pid=1-s2.0-S1808869424000107-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139558791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional cognitive behavior therapy for persistent postural-perceptual dizziness: a meta-analysis","authors":"Jialin Zang ,&nbsp;Mohan Zheng ,&nbsp;Hongyuan Chu ,&nbsp;Xu Yang","doi":"10.1016/j.bjorl.2024.101393","DOIUrl":"10.1016/j.bjorl.2024.101393","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate whether additional Cognitive Behavior Therapy (CBT) combined with conventional therapy improves outcomes for patients with Persistent Postural-Perceptual Dizziness (PPPD) compared with conventional therapy alone.</p></div><div><h3>Methods</h3><p>Two reviewers independently searched PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov for relevant Randomized Controlled Trials (RCTs) examining CBT for PPPD which were conducted and published in English from January 2002 to November 2022. RCTs reporting any indicators for assessing corresponding symptoms of PPPD were included, such as Dizziness Handicap Inventory (DHI), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9). Two independent reviewers conducted extraction of relevant information and evaluation of risk of bias. The Cochrane Collaboration risk of bias tool version 1.0 was used to evaluate risks and assess the quality of the included studies, and Cochrane Review Manager 5.3 software (RevMan 5.3) was used to perform meta-analyses.</p></div><div><h3>Results</h3><p>The results of six RCTs indicated that combining additional CBT with conventional therapy significantly improved outcomes for PPPD patients compared with conventional therapy alone, especially in DHI-Total scores (Mean Difference [MD = −8.17], 95% Confidence Interval [95% CI: −10.26, −6.09], <em>p</em> &lt; 0.00001), HAMA scores (MD = −2.76, 95% CI: [−3.57, −1.94], <em>p</em> &lt; 0.00001), GAD-7 scores (MD = −2.50, 95% CI [−3.29, −1.70], <em>p</em> &lt; 0.00001), and PHQ-9 scores (MD = −2.29, 95% CI [−3.04, −1.55], <em>p</em> &lt; 0.00001). Subgroup analysis revealed a significant benefit of additional CBT compared with conventional therapies alone, including Vestibular Rehabilitation Therapy (VRT) (MD = −8.70, 95% CI: [−12.17, −5.22], <em>p</em> &lt; 0.00001), Selective Serotonin Reuptake Inhibitor (SSRI) (with controlled SSRI: MD = −10.70, 95% CI: [−14.97, −6.43], <em>p</em> &lt; 0.00001), and VRT combined with SSRI (MD = −6.08, 95% CI [−9.49, −2.67], <em>p</em> = 0.0005) in DHI-Total scores.</p></div><div><h3>Conclusion</h3><p>Additional CBT combined with conventional therapy may provide additional improvement for patients with PPPD compared with conventional therapy alone. However, more RCTs are needed to support and guide the application of CBT in treating PPPD.</p></div><div><h3>Level of evidence</h3><p>I; Systematic review of RCTs.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869424000089/pdfft?md5=69c4e5914c5734968548976a6bd01ffa&pid=1-s2.0-S1808869424000089-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139558666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necrotizing sialometaplasia on the hard palate after sequential induced vomiting: case study","authors":"Elaine Costa ,&nbsp;Gabriel Caetano de Jesus ,&nbsp;Bruno Siqueira Bellini ,&nbsp;Ana Cristina Coelho Dal Rio Teixeira","doi":"10.1016/j.bjorl.2023.101385","DOIUrl":"10.1016/j.bjorl.2023.101385","url":null,"abstract":"","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869423001532/pdfft?md5=54c324a93f7e454bed183091f73abfd8&pid=1-s2.0-S1808869423001532-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139068300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective prognostic risk model with cuproptosis-related genes in laryngeal cancer","authors":"Cong Li ,&nbsp;Yongzhi Zhu ,&nbsp;Song Shi","doi":"10.1016/j.bjorl.2023.101384","DOIUrl":"10.1016/j.bjorl.2023.101384","url":null,"abstract":"<div><h3>Objective</h3><p>Laryngeal cancer, characterized by high recurrence rates and a lack of effective biomarkers, has been associated with cuproptosis, a regulated cell death process linked to cancer progression. In this study, we aimed to explore the roles of cuproptosis-related genes in laryngeal cancer and their potential as prognostic markers and therapeutic targets.</p></div><div><h3>Methods</h3><p>We collected comprehensive data from The Cancer Genome Atlas and Gene Expression Omnibus databases, including gene expression profiles and clinical data of laryngeal cancer patients. Using clustering and gene analysis, we identified cuproptosis-related genes with prognostic significance. A risk model was constructed based on these genes, categorizing patients into high- and low-risk groups for outcome comparison. Univariate and multivariate analyses were conducted to identify independent prognostic factors, which were then incorporated into a nomogram. Gene Set Enrichment Analysis was employed to explore pathways distinguishing high- and low-risk groups.</p></div><div><h3>Results</h3><p>Our risk model, based on four genes, including transmembrane 2, dishevelled binding antagonist of β-catenin 1, stathmin 2, and G protein-coupled receptor 173, revealed significant differences in patient outcomes between high- and low-risk groups. Independent prognostic factors were identified and integrated into a nomogram, providing a valuable tool for prognostic prediction. Gene Set Enrichment Analysis uncovered up-regulated pathways specifically associated with high-risk patient samples.</p></div><div><h3>Conclusion</h3><p>This study highlights the potential of cuproptosis-related genes as valuable prognostic markers and promising therapeutic targets in the context of laryngeal cancer. This research sheds light on new avenues for understanding and managing this challenging disease.</p></div><div><h3>Level of evidence</h3><p>Level 4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869423001520/pdfft?md5=fb94ed3fc8840b4163564f9320a0720f&pid=1-s2.0-S1808869423001520-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139056492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detailed analysis of inner ear malformations in CHARGE syndrome patients – correlation with audiological results and proposal for computed tomography scans evaluation methodology","authors":"Agata Szleper ,&nbsp;Magdalena Lachowska ,&nbsp;Tomasz Wojciechowski ,&nbsp;Katarzyna Pronicka-Iwanicka","doi":"10.1016/j.bjorl.2023.101383","DOIUrl":"10.1016/j.bjorl.2023.101383","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim was to describe the spectrum of inner ear malformations in CHARGE syndrome and propose a Computed Tomography (CT) detailed scan evaluation methodology. The secondary aim was to correlate the CT findings with hearing thresholds.</p></div><div><h3>Methods</h3><p>Twenty ears of ten patients diagnosed with CHARGE syndrome were subjected to CT analysis focusing on the inner ear and internal acoustic canal. The protocol used is presented in detail. ASSR results were analyzed and correlated with inner ear malformations.</p></div><div><h3>Results</h3><p>Cochlear hypoplasia type III was the most common malformation found in 12 ears (60%). Cochlear hypoplasia type II, aplasia with a dilated vestibule, and rudimentary otocyst were also identified. In 20%, no cochlear anomaly was found. The lateral Semicircular Canal (SCC) absence affected 100% of ears, the absence of the posterior SCC 95%, and the superior SCC 65%. Better development of cochlea structures and IAC correlated significantly with the lower hearing thresholds.</p></div><div><h3>Conclusion</h3><p>This study demonstrated that rudimentary SCC or a complete absence of these SCCs was universally observed in all patients diagnosed with CHARGE syndrome. This finding supports the idea that inner ear anomalies are a hallmark feature of the CHARGE, contributing to its distinct clinical profile. The presence of inner ear malformations has substantial clinical implications. Audiological assessments are crucial for CHARGE syndrome, as hearing loss is common. Early detection of these malformations can guide appropriate interventions, such as hearing aids or cochlear implants, which may significantly improve developmental outcomes and communication for affected individuals. Recognizing inner ear malformations as a diagnostic criterion presents implications beyond clinical diagnosis. A better understanding of these malformations can advance the knowledge of CHARGE pathophysiology. It may also help guide future research into targeted therapies to mitigate the impact of inner ear anomalies on hearing and balance function.</p></div><div><h3>Level of evidence</h3><p>4.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869423001519/pdfft?md5=1a40bb95c48556d02ea8656463431581&pid=1-s2.0-S1808869423001519-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139030233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal variation in human temporal bone using rigid endoscope","authors":"Thales Xavit Souza e Silva,&nbsp;Aline Bruno Figueiredo Nicolau,&nbsp;Marcos Luiz Antunes","doi":"10.1016/j.bjorl.2023.101381","DOIUrl":"10.1016/j.bjorl.2023.101381","url":null,"abstract":"<div><h3>Objective</h3><p>Compare thermal variation in the region of the External Acoustic Canal (EAC) and the Round Window (RW) using different rigid endoscopes and light sources in human temporal bones.</p></div><div><h3>Method</h3><p>This is an analytical experimental study using human temporal bones. Thermal variation was assessed during ten minutes, using a thermometer in the region of the EAC and the RW of two temporal bones, right and left. We used three different endoscopes (0° 4-mm, 0° 3-mm and 30° 4-mm) and five intensity/type light source (Halogen 100%, LED 50%, LED 100%, Xenon 50% and Xenon 100% with the same endoscope light fiber.</p></div><div><h3>Results</h3><p>We found temperature elevations in the EAC and RW in all measurements. Larger caliber endoscopes (4-mm) and light sources at 100% intensity generated higher temperatures, slightly higher in halogen and xenon. The 30° endoscopes tended to put more heat on structures, with little difference in most measurements. We identified greater temperature variations in the EAC of the right and left temporal bones compared to the RW overall. The highest temperature acquired in the present study was in the EAC of the temporal bone with a 4-mm and 30° endoscope, using xenon light source (intensity of 100%), with an increase of 4.51 °C.</p></div><div><h3>Conclusion</h3><p>The type of endoscope and light source can influence the thermal variation and the risk of tissue injury during endoscopic ear surgery. Larger endoscopes with xenon and halogen light sources at maximum intensity generate more heat.</p></div><div><h3>Level of evidence</h3><p>5.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869423001490/pdfft?md5=bcaab238dfefca3bc1717b22cce2b9c9&pid=1-s2.0-S1808869423001490-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One simple question detects motion sickness susceptibility in migraine patients","authors":"Gülden Akdal ,&nbsp;Pınar Özçelik ,&nbsp;Birgül Balcı ,&nbsp;Gábor Michael Halmágyi ,&nbsp;Belgin Ünal","doi":"10.1016/j.bjorl.2023.101382","DOIUrl":"10.1016/j.bjorl.2023.101382","url":null,"abstract":"<div><h3>Objective</h3><p>To find out if motion sickness susceptibility (MSS) of vestibular migraine (VM) patients and migraine only (MO) patients can be reliably detected with a single simple question: “Can you read while travelling in a car without getting motion sick?”.</p></div><div><h3>Method</h3><p>Ninety-two definite VM and 58 MO patients and 74 healthy control (HC) subjects were asked about their MSS and about being able to read while riding in a car without becoming motion sick. A Motion Sickness Susceptibility Questionnaire (MSSQ-Short) including childhood (MSA), adulthood (MSB) and total (MST) parts was also administered to all participants. ROC curves of MSSQ-Short were prepared for “not being able to read in a car” as the gold standard.</p></div><div><h3>Results</h3><p>Mean MSA scores were significantly higher in both VM and MO patients than in HCs (<em>p</em> &lt; 0.001), but their scores were not significantly different (<em>p</em> = 0.171). Mean MSB and MST scores were significantly higher in VM than in MO patients (<em>p</em> &lt; 0.001) and both VM and MO patients had significantly higher scores than HCs (<em>p</em> &lt; 0.001). MSA scores were significantly higher than MSB scores in MO patients (<em>p</em> &lt; 0.001). All sections of the questionnaire were associated with high area-under-curve values for MSS detected by the question about being able to read in a car without becoming motion sick.</p></div><div><h3>Conclusion</h3><p>We propose that all migraine patients could have the same level of MSS in childhood but MO patients are able to compensate over years, but VM patients are not. A quick way to determine MSS is to ask about the ability to read without becoming motion sickness while riding a car.</p></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1808869423001507/pdfft?md5=2bd216b01b6e20c46dfdf03b18ff1f1d&pid=1-s2.0-S1808869423001507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}