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Prognostic factors for early-stage triple-negative breast cancer with a focus on neutrophil-to-lymphocyte ratio: A single-center retrospective study 早期三阴性乳腺癌的预后因素与中性粒细胞与淋巴细胞比率：一项单中心回顾性研究
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.04.019
Yu-Kwang Lee , Chen-Yang Hsu , Ming-Yang Wang , Wen-Hung Kuo , Huang-Chun Lien , Yi-Hsuan Lee , Chiao Lo , Chiun-Sheng Huang

Objective

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Prognostic factors for TNBC are still inconclusive due to its heterogeneity. Neutrophil-to-lymphocyte ratio (NLR) has been reported as a valuable and cost effective prognostic tool for breast cancer patients. In this study, we aim to identify the prognostic factors for TNBC with a focus on NLR.

Materials and methods

We retrospectively analyzed stage I-III TNBC patients receiving upfront operation at National Taiwan University Hospital (NTUH) between January 2015 and December 2021. Age, tumor size, lymph node metastasis, cancer stage, histologic grade, lymphovascular invasion, perineural invasion, Ki67 levels, and neutrophil-to-lymphocyte ratio (NLR) were analyzed as prognostic factors. We used 3.4 as the cutoff point for NLR.

Results

We identified 248 stage I-III patients, the overall 5-year disease-free survival (DFS) was 90.2 %. The median follow-up duration was 52.3 months. Twenty-one patients (8.5 %) experienced recurrence, with 8 local-regional and 13 distant recurrences. Compared with patients without recurrence, patients with recurrence had more advanced cancer stage, bigger tumor size, higher percentage of lymph node metastasis, and higher NLR. Multivariate analysis showed that recurrence of TNBC is 3.6 times higher in patients with lymph node metastasis than those without, and it is also 8.9 times higher in patients with baseline NLR >3.4 than ≤3.4.

Conclusion

Lymph node metastasis and elevated NLR are significant predictors of poor DFS in TNBC patients undergoing upfront surgery. Patients with NLR higher than 3.4 have a worse prognosis.
目的三阴性乳腺癌（TNBC）是一种侵袭性乳腺癌亚型。由于其异质性，TNBC的预后因素仍不确定。中性粒细胞与淋巴细胞比率（NLR）已被报道为乳腺癌患者的一种有价值且成本有效的预后工具。在这项研究中，我们的目的是确定TNBC的预后因素，重点是NLR。材料与方法回顾性分析2015年1月至2021年12月在国立台湾大学医院（NTUH）接受术前手术的I-III期TNBC患者。年龄、肿瘤大小、淋巴结转移、肿瘤分期、组织学分级、淋巴血管浸润、神经周围浸润、Ki67水平、中性粒细胞与淋巴细胞比值（NLR）作为预后因素进行分析。我们使用3.4作为NLR的分界点。结果248例I-III期患者，总5年无病生存率（DFS）为90.2%。中位随访时间为52.3个月。21例（8.5%）复发，8例局部复发，13例远处复发。与无复发患者相比，复发患者肿瘤分期更晚期，肿瘤体积更大，淋巴结转移率更高，NLR更高。多因素分析显示，有淋巴结转移的患者TNBC复发率是无淋巴结转移患者的3.6倍，基线NLR >；3.4的患者TNBC复发率是基线NLR≤3.4的8.9倍。结论淋巴结转移和NLR升高是TNBC患者术前DFS差的重要预测因素。NLR高于3.4的患者预后较差。
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引用次数: 0
Ascites after assistance reproductive technology 辅助生殖技术后腹水
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.09.020
Szu-Ting Yang, Wen-Hsun Chang, Peng-Hui Wang
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引用次数: 0
Updating the impact of mRNA COVID-19 vaccine exposure during pregnancy on obstetric and neonatal outcomes 更新妊娠期间mRNA COVID-19疫苗暴露对产科和新生儿结局的影响
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.07.022
Frank Adusei-Mensah , Olubunmi Olubamwo , Sunday Olaleye , Laboni Akter , Oluwafemi Samson Balogun , Rethabile Joyce Moshoeshoe , Luqman Awoniyi , Adedayo Olawuni , Jussi Kauhanen
Being a new vaccine platform, continuous monitoring of the mRNA COVID-19 vaccines in pregnant women is of critical importance. This systematic review and meta-analysis evaluate the maternal and neonatal outcomes associated with mRNA COVID-19 vaccination during pregnancy. We conducted a systematic search of PubMed, Embase, Cochrane Library, and clinical trial registries for studies published between December 2020 and July 2024. Studies were included if they assessed obstetric and neonatal outcomes following mRNA COVID-19 vaccination in pregnant women. Data were extracted and analyzed using a random-effects model to calculate pooled odds ratios (ORs) and 95 % confidence intervals (CIs). Fifteen studies met the inclusion criteria, encompassing 42,944 vaccinated and 183,733 unvaccinated pregnant women. mRNA vaccination was associated with a significant reduction in preterm delivery (OR 0.743, 95 % CI 0.607–0.911), fetal distress (OR 0.699, 95 % CI 0.546–0.893), neonatal congenital abnormalities (OR 0.712, 95 % CI 0.570–0.889), and NICU admissions (OR 0.718, 95 % CI 0.617–0.836). However, a slight increase in gestational diabetes risk was observed (OR 1.107, 95 % CI 1.054–1.162). mRNA COVID-19 vaccines are safe during pregnancy and associated with reduced risks of adverse obstetric and neonatal outcomes. An observed marginal increase in gestational diabetes risk underscores the need for continuous monitoring. These findings support the inclusion of pregnant women in vaccination campaigns and inform public health policies and clinical practices to improve maternal and neonatal health outcomes.
作为一个新的疫苗平台，持续监测孕妇的mRNA COVID-19疫苗至关重要。本系统综述和荟萃分析评估了与妊娠期mRNA - COVID-19疫苗接种相关的孕产妇和新生儿结局。我们对PubMed、Embase、Cochrane图书馆和临床试验注册库进行了系统检索，检索了2020年12月至2024年7月间发表的研究。如果研究评估孕妇接种mRNA COVID-19疫苗后的产科和新生儿结局，则纳入研究。采用随机效应模型提取和分析数据，计算合并优势比（ORs）和95%置信区间（ci）。15项研究符合纳入标准，包括42944名接种疫苗的孕妇和183733名未接种疫苗的孕妇。mRNA疫苗接种与早产（OR 0.743, 95% CI 0.607-0.911）、胎儿窘迫（OR 0.699, 95% CI 0.546-0.893）、新生儿先天性异常（OR 0.712, 95% CI 0.570-0.889）和新生儿重症监护病房入院（OR 0.718, 95% CI 0.617-0.836）的显著降低相关。然而，观察到妊娠糖尿病风险略有增加（OR 1.107, 95% CI 1.054-1.162）。mRNA - COVID-19疫苗在妊娠期间是安全的，并可降低不良产科和新生儿结局的风险。观察到的妊娠期糖尿病风险的边际增加强调了持续监测的必要性。这些发现支持将孕妇纳入疫苗接种运动，并为公共卫生政策和临床实践提供信息，以改善孕产妇和新生儿的健康结果。
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引用次数: 0
Follow-up of a 2-year-and-6-month-old boy with a favorable outcome and a prenatal history of low-level mosaic trisomy 13 at amniocentesis 对一名2岁6个月男婴进行羊膜穿刺术随访，结果良好，产前有低水平马赛克13三体病史
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.09.016
Chih-Ping Chen
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引用次数: 0
Common on “Prenatal diagnosis of a de novo 16p11.2 microduplication of 16p11.2 BP4-5 copy number variants in a fetus with apparently normal phenotype” 常见于“明显表型正常的胎儿中16p11.2 BP4-5拷贝数变异的新生儿16p11.2微重复的产前诊断”
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.07.028
Jiaxuan Tan, Hongmei Shen
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引用次数: 0
High-level mosaic trisomy 9 at amniocentesis in a pregnancy with a positive non-invasive prenatal testing result for trisomy 9, intrauterine growth restriction, fetal structural abnormality, cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, maternal uniparental disomy 9, a normal karyotype at birth, perinatal progressive decrease of the trisomy 9 cell line, concomitant heterozygous mutations of POLG2 and DCC and an adverse fetal outcome 妊娠期羊膜穿刺术中高水平镶嵌9三体，无创产前9三体检测阳性，宫内生长受限，胎儿结构异常，培养羊膜细胞与未培养羊膜细胞细胞遗传学差异，母体单倍体9，出生时核型正常，围产期9三体细胞系进行性减少，POLG2和DCC杂合突变，胎儿预后不良
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.09.012
Chih-Ping Chen
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引用次数: 0
Postoperative adhesions: A persistent challenge with preventable solutions 术后粘连：可预防解决方案的持续挑战
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.07.020
Chyi-Long Lee
{"title":"Postoperative adhesions: A persistent challenge with preventable solutions","authors":"Chyi-Long Lee","doi":"10.1016/j.tjog.2025.07.020","DOIUrl":"10.1016/j.tjog.2025.07.020","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 947-948"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Instruction for Authors 作者须知
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/S1028-4559(25)00293-1
{"title":"Instruction for Authors","authors":"","doi":"10.1016/S1028-4559(25)00293-1","DOIUrl":"10.1016/S1028-4559(25)00293-1","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages E1-E7"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative laparoscopic ultrasound during laparoscopic myomectomy for a degenerating myoma seems beneficial for improving outcomes: A case report 术中腹腔镜超声在腹腔镜子宫肌瘤切除术退行性肌瘤似乎有利于改善结果：一个病例报告
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.07.025
Yoshifumi Kasuga, Jun Watanabe, Moeko Sakuma, Mamoru Tanaka
{"title":"Intraoperative laparoscopic ultrasound during laparoscopic myomectomy for a degenerating myoma seems beneficial for improving outcomes: A case report","authors":"Yoshifumi Kasuga,&nbsp;Jun Watanabe,&nbsp;Moeko Sakuma,&nbsp;Mamoru Tanaka","doi":"10.1016/j.tjog.2025.07.025","DOIUrl":"10.1016/j.tjog.2025.07.025","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1085-1086"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibody-drug conjugates (ADCs) may be a big breakthrough in gynecologic cancer treatment (III): Understanding of ADC 抗体-药物偶联物（ADC）可能是妇科癌症治疗的一大突破（三）：对ADC的认识
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Taiwanese Journal of Obstetrics & Gynecology
Pub Date : 2025-11-01 DOI: 10.1016/j.tjog.2025.09.003
Peng-Hui Wang, Szu-Ting Yang, Wen-Hsun Chang
{"title":"Antibody-drug conjugates (ADCs) may be a big breakthrough in gynecologic cancer treatment (III): Understanding of ADC","authors":"Peng-Hui Wang,&nbsp;Szu-Ting Yang,&nbsp;Wen-Hsun Chang","doi":"10.1016/j.tjog.2025.09.003","DOIUrl":"10.1016/j.tjog.2025.09.003","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 935-937"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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