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Erosive stitches of cervical cerclage as a factor of abnormal uterine bleeding: A report of two cases 宫颈环扎术的腐蚀性缝线是导致异常子宫出血的因素之一:两个病例的报告
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.08.003
Hung-Ting Chang , Shin-Yin Huang , Ming-Chao Huang

Objective

Abnormal uterine bleeding (AUB) is a prevalent condition in reproductive-aged women that significantly decreases the quality of life. A thorough history is necessary to determine the causes of AUB, which were categorized by the AUB System 2 (PALM-COEIN). AUB has been associated with retained intrauterine objects. However, studies regarding AUB caused by retained stitches of the cervical cerclage were limited.

Case Report

We present two cases of AUB caused by retained stitches of the cervical cerclage. Both cases were successfully treated by removing the retained stitches by hysteroscopy.

Conclusion

A comprehensive history is crucial to AUB evaluation, especially a previous history of iatrogenic processes, such as intrauterine device placement, retained cerclage stitches, or other foreign bodies.
目的异常子宫出血(AUB)是育龄妇女的一种常见病,严重降低了她们的生活质量。要确定 AUB 的病因,必须详细了解病史,并根据 AUB 系统 2(PALM-COEIN)进行分类。AUB 与宫内残留物有关。病例报告我们介绍了两例由宫颈环扎的留置针引起的 AUB。结论全面的病史对 AUB 的评估至关重要,尤其是既往的先天性病史,如宫内节育器放置、宫颈环扎缝线残留或其他异物。
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引用次数: 0
Detection of a heterozygous de novo pathogenic variant in the PTPN11 gene (c.1505 C > T, p.S502L) in a fetus associated with cystic hygroma and congenital heart defects 在一个伴有囊性透明瘤和先天性心脏缺陷的胎儿中检测到 PTPN11 基因中的一个新发杂合致病变体(c.1505 C > T, p.S502L)。
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.016
Chih-Ping Chen
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引用次数: 0
Mosaicism for r(20) or 46,XY,r(20)(p13q13.3)/46,XY at amniocentesis in a pregnancy with a favorable outcome and no prominent perinatal decrease of the r(20) cell line with no genomic imbalance 在羊膜穿刺术中发现r(20)或46,XY,r(20)(p13q13.3)/46,XY嵌合体,但妊娠结局良好,围产期r(20)细胞系无明显减少,且无基因组失衡现象
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.017
Chih-Ping Chen
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引用次数: 0
The trend and factors associated with severe maternal morbidity among delivery and postpartum hospitalizations in Taiwan: A nationwide study, 2011–2021 台湾分娩和产后住院产妇严重发病率的趋势和相关因素:2011-2021 年全国性研究
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.03.024
Wen-Chu Huang , Chi-Chen Chen , Shou-Hsia Cheng

Objective

To investigate the prevalence and longitudinal trend of severe maternal morbidity (SMM) at nationwide level in Taiwan. The associated maternal factors contributing to SMM were also analyzed.

Materials and methods

A population-based secondary analysis using administrative datasets released by Ministry of Health and Welfare of Taiwan from 2011 to 2021 was carried out. SMM was defined from ICD-9 or10-CM diagnosis and procedure codes previously released by CDC. The existence of any SMM indicators identified by delivery and postpartum hospitalizations between≧20 weeks of gestational age and within 42 days after childbirth was retrieved for analysis. Kendall Tau-b correlation was applied for trend test. Logistic regression was used to investigate the associated maternal factors for SMM. All the data were analyzed using SAS statistical software version 9.4. Statistical significance was defined as P value < 0.05.

Results

A total of 2,054,010 delivery hospitalization records were identified during the study period. 6961 subjects met the SMM indicators, yielding an average SMM rate of 3.4 per 1000 deliveries. The pure transfusion rate was 2.33%. The overall SMM rate including transfusion reached 26.7 per thousand deliveries. The trend of SMM including and excluding transfusion demonstrated significantly increasing. Extreme maternal age and cesarean delivery were two main maternal associated factors for SMM.

Conclusion

Our findings demonstrated the steadily increasing trend of SMM in the past decade from nationwide study in Taiwan. The sharply growing rates of blood transfusion made the prevention of obstetric hemorrhage imperative. Health policies should be focused on the encourage of early childbearing and avoidance of unnecessary cesarean delivery to reduce the maternal risks associated with SMM. Continuous surveillance of SMM is required to improve obstetric care and reduce severe maternal complications.
目的 调查台湾全国范围内严重孕产妇发病率(SMM)的患病率和纵向趋势,并分析导致严重孕产妇发病率的相关孕产妇因素。材料与方法利用台湾卫生福利部发布的 2011 年至 2021 年行政数据集进行了基于人口的二次分析。SMM 的定义来自疾控中心之前发布的 ICD-9 或 10-CM 诊断和手术代码。在胎龄≧20周和产后42天内,通过分娩和产后住院确定的任何SMM指标都会被检索出来进行分析。趋势检验采用 Kendall Tau-b 相关性。采用逻辑回归法研究SMM的相关孕产因素。所有数据均使用 SAS 统计软件 9.4 版进行分析。统计显著性定义为 P 值 < 0.05。有 6961 例符合 SMM 指标,平均每 1000 例分娩中有 3.4 例符合 SMM 指标。纯输血率为 2.33%。包括输血在内的总体 SMM 比率达到每千次分娩 26.7 例。包括输血和不包括输血的 SMM 呈明显上升趋势。高龄产妇和剖宫产是 SMM 的两个主要相关因素。输血率的急剧上升使得预防产科出血成为当务之急。卫生政策的重点应放在鼓励早育和避免不必要的剖腹产上,以降低 SMM 带来的产妇风险。需要对 SMM 进行持续监测,以改善产科护理,减少严重的孕产妇并发症。
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引用次数: 0
Retrospective evaluation of obstetric processes in patients with Familial Mediterranean Fever's disease: The three years experience of a tertiary rheumatology clinic 对家族性地中海热病患者产科过程的回顾性评估:一家三级风湿病诊所的三年经验
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.008
Rabia Deniz , Ferdanur Deniz , Şevket Ali Ekmen , Duygu Sevinç-Özgür , Gamze Akkuzu , Bilgin Karaalioğlu , Fatih Yıldırım , Burak İnce , Kübra Kalkan , Gül Güzelant Özköse , Cemal Bes

Objectives

Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease affecting both genders in reproductive age. In this study, we aimed to investigate the relation between FMF and pregnancy on both maternal and fetal aspects.

Material and methods

In this retrospective, single-center, descriptive study we analysed total of 95 pregnancies of 40 FMF patients. Clinical and demographic data were obtained from patients’ records. To prevent recall bias, only the last pregnancy of each patient was evaluated for disease activity and use or revision of medications during pregnancy.

Results

The median age of the patients at diagnosis was 22 and the first pregnancy age was 26 years. The median duration of FMF at last pregnancy was 8 (0–23) years. Eight (20%) patients had at least 1 pregnancy via assisted reproductive techniques (IVF), while 34 (85%) patients had at least 1 spontaneous pregnancy. While 32 patients were in remission (80%) before pregnancy, 8 were clinically active (20%). Improvement in clinical course and attack frequency during pregnancy was observed in 23 patients (57.5%), stable course in 10 (25.0%), and worsening in 7 (17.5%). The rate of live birth was 70.0%, abortus was 28.9%, preterm labor was 8.1%, pre-eclampsia was 5.0%, and only 1 achondroplasia as congenital fetal abnormality was observed.

Conclusion

FMF did not constitute a contraindication for pregnancy. The most important obstetric problems, complications, and negative fetal outcomes in the course of pregnancy are increased IVF requirement, abortion, and cesarean rates. There is no increase in the risk of congenital malformations due to FMF itself or use of colchicine.
目的地中海家族性高热(Familial Mediterranean Fever,FMF)是一种遗传性自身炎症性疾病,对育龄期男女均有影响。在这项研究中,我们旨在从母体和胎儿两方面研究 FMF 与妊娠之间的关系。材料和方法在这项回顾性、单中心、描述性研究中,我们分析了 40 名 FMF 患者的 95 次妊娠。临床和人口统计学数据均来自患者的病历。为防止回忆偏差,我们仅对每位患者的最后一次妊娠进行了评估,以了解其疾病活动情况以及在妊娠期间使用或更换药物的情况。结果患者确诊时的中位年龄为 22 岁,首次妊娠年龄为 26 岁。最后一次怀孕时,FMF 的中位持续时间为 8(0-23)年。8名患者(20%)至少有一次通过辅助生殖技术(IVF)怀孕,34名患者(85%)至少有一次自然怀孕。32 名患者(80%)在怀孕前病情得到缓解,8 名患者(20%)病情处于临床活动期。妊娠期间,23 名患者(57.5%)的临床病程和发作频率有所改善,10 名患者(25.0%)的病程稳定,7 名患者(17.5%)的病情恶化。活产率为 70.0%,流产率为 28.9%,早产率为 8.1%,子痫前期为 5.0%,仅发现 1 例软骨发育不全为先天性胎儿畸形。妊娠过程中最重要的产科问题、并发症和胎儿不良结局是体外受精需求、流产和剖宫产率增加。FMF 本身或使用秋水仙碱不会增加先天性畸形的风险。
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引用次数: 0
Antibody–drug conjugates (ADCs) may be a big breakthrough in gynecologic cancer treatment (I) 抗体药物共轭物 (ADC) 或将成为妇科癌症治疗的一大突破 (I)
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.005
Peng-Hui Wang, Chia-Hao Liu, Szu-Ting Yang
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引用次数: 0
Clinical and sonographic risk factors for developing pre-eclampsia refractory to aspirin prophylaxis 阿司匹林预防难治性先兆子痫的临床和超声风险因素
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.01.038
Chia-Chen Lee , Chie-Pein Chen , Chen-Yu Chen , Liang-Kai Wang , Yi-Yung Chen

Objective

Identify risk factors for development of preeclampsia refractory to aspirin prophylaxis in women at high-risk of preeclampsia.

Material and methods

A retrospective cohort study analyzed 206 women identified as high-risk for preeclampsia through first-trimester screening and prescribed aspirin prophylaxis. We compared maternal characteristics, medical history, biochemical markers, and uterine artery Doppler indices between those with and without preeclampsia.

Results

Women with preeclampsia had significantly higher rates of chronic hypertension (54.3% vs. 8.2%), higher first-trimester mean arterial pressure (MAP, 109.6 vs. 95.4 mmHg), and higher body mass index (BMI, 27.6 vs. 24.9) compared to controls. Second-trimester MAP and mean uterine artery pulsatility index (UtA-PI) were also significantly elevated in the preeclampsia group (103.3 mmHg and 1.39, respectively) compared to controls (89.7 mmHg and 1.05). ROC curve analysis identified an optimal second trimester UtA-PI cut-off of 1.36 for predicting preeclampsia, with sensitivity of 49% and specificity of 87.1%. When using a cut-off value of 0.77 for the second-to-first trimester UtA-PI ratio, the sensitivity and specificity were 60% and 90.6%, respectively.

Conclusion

Chronic hypertension, high first and second trimester MAP, higher BMI, and elevated second trimester UtA-PI are associated with preeclampsia despite aspirin prophylaxis. Evaluating second trimester UtA-PI or the ratio of second to first trimester UtA-PI may be a promising tool for identifying women who do not respond to aspirin.
材料与方法回顾性队列研究分析了 206 名通过产前筛查被确定为子痫前期高危并服用阿司匹林预防的妇女。结果与对照组相比,子痫前期妇女的慢性高血压发病率明显更高(54.3% 对 8.2%),第一胎平均动脉压(MAP,109.6 对 95.4 mmHg)更高,体重指数(BMI,27.6 对 24.9)也更高。与对照组(89.7 mmHg 和 1.05)相比,子痫前期组的第二胎 MAP 和平均子宫动脉搏动指数(UtA-PI)也明显升高(分别为 103.3 mmHg 和 1.39)。ROC曲线分析确定了预测子痫前期的最佳第二孕期UtA-PI临界值为1.36,灵敏度为49%,特异性为87.1%。结论 尽管服用了阿司匹林预防措施,但慢性高血压、前三个月和后三个月高 MAP、较高的体重指数和后三个月升高的 UtA-PI 与子痫前期相关。评估第二孕期UtA-PI或第二孕期UtA-PI与第一孕期UtA-PI的比值可能是识别对阿司匹林无反应的妇女的有效工具。
{"title":"Clinical and sonographic risk factors for developing pre-eclampsia refractory to aspirin prophylaxis","authors":"Chia-Chen Lee ,&nbsp;Chie-Pein Chen ,&nbsp;Chen-Yu Chen ,&nbsp;Liang-Kai Wang ,&nbsp;Yi-Yung Chen","doi":"10.1016/j.tjog.2024.01.038","DOIUrl":"10.1016/j.tjog.2024.01.038","url":null,"abstract":"<div><h3>Objective</h3><div>Identify risk factors for development of preeclampsia refractory to aspirin prophylaxis in women at high-risk of preeclampsia.</div></div><div><h3>Material and methods</h3><div>A retrospective cohort study analyzed 206 women identified as high-risk for preeclampsia through first-trimester screening and prescribed aspirin prophylaxis. We compared maternal characteristics, medical history, biochemical markers, and uterine artery Doppler indices between those with and without preeclampsia.</div></div><div><h3>Results</h3><div>Women with preeclampsia had significantly higher rates of chronic hypertension (54.3% vs. 8.2%), higher first-trimester mean arterial pressure (MAP, 109.6 vs. 95.4 mmHg), and higher body mass index (BMI, 27.6 vs. 24.9) compared to controls. Second-trimester MAP and mean uterine artery pulsatility index (UtA-PI) were also significantly elevated in the preeclampsia group (103.3 mmHg and 1.39, respectively) compared to controls (89.7 mmHg and 1.05). ROC curve analysis identified an optimal second trimester UtA-PI cut-off of 1.36 for predicting preeclampsia, with sensitivity of 49% and specificity of 87.1%. When using a cut-off value of 0.77 for the second-to-first trimester UtA-PI ratio, the sensitivity and specificity were 60% and 90.6%, respectively.</div></div><div><h3>Conclusion</h3><div>Chronic hypertension, high first and second trimester MAP, higher BMI, and elevated second trimester UtA-PI are associated with preeclampsia despite aspirin prophylaxis. Evaluating second trimester UtA-PI or the ratio of second to first trimester UtA-PI may be a promising tool for identifying women who do not respond to aspirin.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"63 6","pages":"Pages 874-879"},"PeriodicalIF":2.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal diagnosis of 9q34.3 microdeletion-associated Kleefstra syndrome in a pregnancy complicated by polyhydramnios: A case report and literature review 产前诊断 9q34.3 微缺失相关 Kleefstra 综合征并发多胎妊娠:病例报告和文献综述
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.06.013
Yi-Yun Tai , Chih-Ling Chen , Chen-Tu Wu , Chien-Nan Lee , Shin-Yu Lin

Objective

Kleefstra Syndrome (KS) is a rare genetic disorder caused by a deletion at 9q34.3. Studies showed that various heart defects are observed in 41–43% of patients and abnormal features on brain imaging in 58–63%. To date, the prenatal phenotype in KS has yet to be defined.

Case report

We present the first prenatal diagnosis and chromosomal microarray analysis (CMA) of a case of 9q34.3 microdeletion in a fetus with increased amniotic fluid, supported by abnormal prenatal ultrasound findings, and confirmed via autopsy. CMA revealed a 2.1 Mb 9q34.3 microdeletion encompassing an OMIM gene of EHMT1, which is consistent with the diagnosis of Kleefstra syndrome and 9q subtelomeric deletion syndrome.

Conclusion

When a fetus with normal karyotype presents with polyhydramnios or abnormalities noted during second-trimester prenatal ultrasound screening, CMA analysis can be considered as the next step to rule out or confirm the diagnosis of chromosomal or other genetic aberrations.
目的克莱夫斯特拉综合征(KS)是一种罕见的遗传性疾病,由 9q34.3 缺失引起。研究显示,41%-43%的患者会出现各种心脏缺陷,58%-63%的患者会出现脑部成像异常。迄今为止,KS 的产前表型仍未确定。病例报告我们首次对一例羊水增多的 9q34.3 微缺失胎儿进行了产前诊断和染色体微阵列分析(CMA),并得到了异常产前超声检查结果的支持和尸检的证实。结论当染色体核型正常的胎儿出现多羊水或在第二胎产前超声筛查中发现异常时,可考虑进行 CMA 分析,以排除或确诊染色体或其他基因畸变。
{"title":"Prenatal diagnosis of 9q34.3 microdeletion-associated Kleefstra syndrome in a pregnancy complicated by polyhydramnios: A case report and literature review","authors":"Yi-Yun Tai ,&nbsp;Chih-Ling Chen ,&nbsp;Chen-Tu Wu ,&nbsp;Chien-Nan Lee ,&nbsp;Shin-Yu Lin","doi":"10.1016/j.tjog.2024.06.013","DOIUrl":"10.1016/j.tjog.2024.06.013","url":null,"abstract":"<div><h3>Objective</h3><div>Kleefstra Syndrome (KS) is a rare genetic disorder caused by a deletion at 9q34.3. Studies showed that various heart defects are observed in 41–43% of patients and abnormal features on brain imaging in 58–63%. To date, the prenatal phenotype in KS has yet to be defined.</div></div><div><h3>Case report</h3><div>We present the first prenatal diagnosis and chromosomal microarray analysis (CMA) of a case of 9q34.3 microdeletion in a fetus with increased amniotic fluid, supported by abnormal prenatal ultrasound findings, and confirmed via autopsy. CMA revealed a 2.1 Mb 9q34.3 microdeletion encompassing an OMIM gene of EHMT1, which is consistent with the diagnosis of Kleefstra syndrome and 9q subtelomeric deletion syndrome.</div></div><div><h3>Conclusion</h3><div>When a fetus with normal karyotype presents with polyhydramnios or abnormalities noted during second-trimester prenatal ultrasound screening, CMA analysis can be considered as the next step to rule out or confirm the diagnosis of chromosomal or other genetic aberrations.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"63 6","pages":"Pages 948-952"},"PeriodicalIF":2.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-trimester application of expanded non-invasive prenatal testing in the genetic investigation of fetal 1p36 deletion syndrome associated with a familial unbalanced reciprocal translocation of 46,XX,der(1)t(1;2) (p36.2;q37.3)dmat 扩大无创产前检测在与 46,XX,der(1)t(1;2) (p36.2;q37.3)dmat 家族性不平衡互变相关的胎儿 1p36 缺失综合征遗传学研究中的首胎应用
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.009
Chih-Ping Chen , Shun-Long Weng , Fang-Tzu Wu , Peih-Shan Wu , Yen-Ting Pan , Wen-Lin Chen , Chien-Wen Yang , Wayseen Wang

Objective

We present first-trimester application of expanded non-invasive prenatal testing (NIPT) in the genetic investigation of fetal 1p36 deletion syndrome associated with a familial unbalanced reciprocal translocation of 46,XX,der(1)t(1;2) (p36.2;q37.3)dmat.

Case report

A 37-year-old, gravida 2, para 0, woman underwent expanded NIPT at 13 weeks of gestation because of advanced maternal age and the fear of complications of invasive procedures of prenatal diagnosis. She had experienced one spontaneous abortion. The pregnancy was conceived by in vitro fertilization and embryo transfer (IVF-ET) because of tubal occlusion. NIPT was positive for 1p36 deletion. At 17 weeks of gestation, she underwent amniocentesis but intrauterine fetal death occurred after amniocentesis and the pregnancy was terminated. Amniocentesis revealed a derivative chromosome 1 with an aberrant short arm terminal segment of chromosome 1. Subsequent cytogenetic analysis of parental bloods showed a karyotype of 46,XY in the father and a karyotype of 46,XX,t(1;2) (p36.2;q37.3) in the mother. The karyotype of amniocytes was 46,XX,der(1)t(1;2) (p36.2;q37.3)dmat, consistent with partial monosomy 1p (1p36.2→pter) and partial trisomy 2q (2q37.3→qter). Array comparative genomic hybridization (aCGH) analysis on the DNA extracted from cultured amniocytes revealed the result of arr 1p36.33p36.22 (852,863–11,303,452) × 1.0 and arr 2q37.3 (242,785,405–243,068,396) × 3.0 [GRCh 37] with a 10.451-Mb deletion of 1p36.33-p36.22 encompassing 116 OMIM genes including RERE and a 283-kb duplication of 2q37.3 encompassing one OMIM gene of PDCD1.

Conclusion

Expanded NIPT has the advantage of early detection of familial unbalanced reciprocal translocation in the fetus.
目的我们介绍了扩增无创产前检测(NIPT)在胎儿 1p36 缺失综合征(与 46,XX,der(1)t(1;2)(p36.病例报告 一位 37 岁的高龄产妇在妊娠 13 周时接受了扩大的 NIPT 检查。她曾有过一次自然流产的经历。由于输卵管闭塞,她通过体外受精和胚胎移植(IVF-ET)怀孕。NIPT 检测结果呈 1p36 缺失阳性。妊娠 17 周时,她接受了羊膜腔穿刺术,但羊膜腔穿刺术后发生胎儿宫内死亡,妊娠终止。羊膜腔穿刺术发现了 1 号染色体的衍生染色体,1 号染色体的短臂末段异常。随后对父母血液进行的细胞遗传学分析显示,父亲的核型为 46,XY,母亲的核型为 46,XX,t(1;2)(p36.2;q37.3)。羊膜细胞的核型为46,XX,der(1)t(1;2) (p36.2;q37.3)dmat,符合部分单体1p(1p36.2→pter)和部分三体2q(2q37.3→qter)。对从培养羊膜细胞中提取的 DNA 进行的阵列比较基因组杂交(aCGH)分析显示,1p36.33-p36.22(852,863-11,303,452)×1.0 阵列和 2q37.3(242,785,405-243,068,396)×3.0 阵列[GRCh 37]结果显示,1p36.33-p36.22 的缺失为 10.451-Mb 。33-p36.22 包含 116 个 OMIM 基因(包括 RERE),2q37.3 的 283-kb 重复包含一个 OMIM 基因 PDCD1。
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引用次数: 0
Breakthroughs in women's health for treating vasomotor symptoms 妇女健康在治疗血管运动症状方面的突破
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.004
Peng-Hui Wang, Wen-Ling Lee
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引用次数: 0
期刊
Taiwanese Journal of Obstetrics & Gynecology
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