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Antibody–drug conjugates (ADCs) may be a big breakthrough in gynecologic cancer treatment (I) 抗体药物共轭物 (ADC) 或将成为妇科癌症治疗的一大突破 (I)
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.005
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引用次数: 0
Erosive stitches of cervical cerclage as a factor of abnormal uterine bleeding: A report of two cases 宫颈环扎术的腐蚀性缝线是导致异常子宫出血的因素之一:两个病例的报告
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.08.003

Objective

Abnormal uterine bleeding (AUB) is a prevalent condition in reproductive-aged women that significantly decreases the quality of life. A thorough history is necessary to determine the causes of AUB, which were categorized by the AUB System 2 (PALM-COEIN). AUB has been associated with retained intrauterine objects. However, studies regarding AUB caused by retained stitches of the cervical cerclage were limited.

Case Report

We present two cases of AUB caused by retained stitches of the cervical cerclage. Both cases were successfully treated by removing the retained stitches by hysteroscopy.

Conclusion

A comprehensive history is crucial to AUB evaluation, especially a previous history of iatrogenic processes, such as intrauterine device placement, retained cerclage stitches, or other foreign bodies.
目的异常子宫出血(AUB)是育龄妇女的一种常见病,严重降低了她们的生活质量。要确定 AUB 的病因,必须详细了解病史,并根据 AUB 系统 2(PALM-COEIN)进行分类。AUB 与宫内残留物有关。病例报告我们介绍了两例由宫颈环扎的留置针引起的 AUB。结论全面的病史对 AUB 的评估至关重要,尤其是既往的先天性病史,如宫内节育器放置、宫颈环扎缝线残留或其他异物。
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引用次数: 0
Detection of a heterozygous de novo pathogenic variant in the PTPN11 gene (c.1505 C > T, p.S502L) in a fetus associated with cystic hygroma and congenital heart defects 在一个伴有囊性透明瘤和先天性心脏缺陷的胎儿中检测到 PTPN11 基因中的一个新发杂合致病变体(c.1505 C > T, p.S502L)。
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.016
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引用次数: 0
Mosaicism for r(20) or 46,XY,r(20)(p13q13.3)/46,XY at amniocentesis in a pregnancy with a favorable outcome and no prominent perinatal decrease of the r(20) cell line with no genomic imbalance 在羊膜穿刺术中发现r(20)或46,XY,r(20)(p13q13.3)/46,XY嵌合体,但妊娠结局良好,围产期r(20)细胞系无明显减少,且无基因组失衡现象
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.017
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引用次数: 0
The trend and factors associated with severe maternal morbidity among delivery and postpartum hospitalizations in Taiwan: A nationwide study, 2011–2021 台湾分娩和产后住院产妇严重发病率的趋势和相关因素:2011-2021 年全国性研究
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.03.024

Objective

To investigate the prevalence and longitudinal trend of severe maternal morbidity (SMM) at nationwide level in Taiwan. The associated maternal factors contributing to SMM were also analyzed.

Materials and methods

A population-based secondary analysis using administrative datasets released by Ministry of Health and Welfare of Taiwan from 2011 to 2021 was carried out. SMM was defined from ICD-9 or10-CM diagnosis and procedure codes previously released by CDC. The existence of any SMM indicators identified by delivery and postpartum hospitalizations between≧20 weeks of gestational age and within 42 days after childbirth was retrieved for analysis. Kendall Tau-b correlation was applied for trend test. Logistic regression was used to investigate the associated maternal factors for SMM. All the data were analyzed using SAS statistical software version 9.4. Statistical significance was defined as P value < 0.05.

Results

A total of 2,054,010 delivery hospitalization records were identified during the study period. 6961 subjects met the SMM indicators, yielding an average SMM rate of 3.4 per 1000 deliveries. The pure transfusion rate was 2.33%. The overall SMM rate including transfusion reached 26.7 per thousand deliveries. The trend of SMM including and excluding transfusion demonstrated significantly increasing. Extreme maternal age and cesarean delivery were two main maternal associated factors for SMM.

Conclusion

Our findings demonstrated the steadily increasing trend of SMM in the past decade from nationwide study in Taiwan. The sharply growing rates of blood transfusion made the prevention of obstetric hemorrhage imperative. Health policies should be focused on the encourage of early childbearing and avoidance of unnecessary cesarean delivery to reduce the maternal risks associated with SMM. Continuous surveillance of SMM is required to improve obstetric care and reduce severe maternal complications.
目的 调查台湾全国范围内严重孕产妇发病率(SMM)的患病率和纵向趋势,并分析导致严重孕产妇发病率的相关孕产妇因素。材料与方法利用台湾卫生福利部发布的 2011 年至 2021 年行政数据集进行了基于人口的二次分析。SMM 的定义来自疾控中心之前发布的 ICD-9 或 10-CM 诊断和手术代码。在胎龄≧20周和产后42天内,通过分娩和产后住院确定的任何SMM指标都会被检索出来进行分析。趋势检验采用 Kendall Tau-b 相关性。采用逻辑回归法研究SMM的相关孕产因素。所有数据均使用 SAS 统计软件 9.4 版进行分析。统计显著性定义为 P 值 < 0.05。有 6961 例符合 SMM 指标,平均每 1000 例分娩中有 3.4 例符合 SMM 指标。纯输血率为 2.33%。包括输血在内的总体 SMM 比率达到每千次分娩 26.7 例。包括输血和不包括输血的 SMM 呈明显上升趋势。高龄产妇和剖宫产是 SMM 的两个主要相关因素。输血率的急剧上升使得预防产科出血成为当务之急。卫生政策的重点应放在鼓励早育和避免不必要的剖腹产上,以降低 SMM 带来的产妇风险。需要对 SMM 进行持续监测,以改善产科护理,减少严重的孕产妇并发症。
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引用次数: 0
Retrospective evaluation of obstetric processes in patients with Familial Mediterranean Fever's disease: The three years experience of a tertiary rheumatology clinic 对家族性地中海热病患者产科过程的回顾性评估:一家三级风湿病诊所的三年经验
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.008

Objectives

Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease affecting both genders in reproductive age. In this study, we aimed to investigate the relation between FMF and pregnancy on both maternal and fetal aspects.

Material and methods

In this retrospective, single-center, descriptive study we analysed total of 95 pregnancies of 40 FMF patients. Clinical and demographic data were obtained from patients’ records. To prevent recall bias, only the last pregnancy of each patient was evaluated for disease activity and use or revision of medications during pregnancy.

Results

The median age of the patients at diagnosis was 22 and the first pregnancy age was 26 years. The median duration of FMF at last pregnancy was 8 (0–23) years. Eight (20%) patients had at least 1 pregnancy via assisted reproductive techniques (IVF), while 34 (85%) patients had at least 1 spontaneous pregnancy. While 32 patients were in remission (80%) before pregnancy, 8 were clinically active (20%). Improvement in clinical course and attack frequency during pregnancy was observed in 23 patients (57.5%), stable course in 10 (25.0%), and worsening in 7 (17.5%). The rate of live birth was 70.0%, abortus was 28.9%, preterm labor was 8.1%, pre-eclampsia was 5.0%, and only 1 achondroplasia as congenital fetal abnormality was observed.

Conclusion

FMF did not constitute a contraindication for pregnancy. The most important obstetric problems, complications, and negative fetal outcomes in the course of pregnancy are increased IVF requirement, abortion, and cesarean rates. There is no increase in the risk of congenital malformations due to FMF itself or use of colchicine.
目的地中海家族性高热(Familial Mediterranean Fever,FMF)是一种遗传性自身炎症性疾病,对育龄期男女均有影响。在这项研究中,我们旨在从母体和胎儿两方面研究 FMF 与妊娠之间的关系。材料和方法在这项回顾性、单中心、描述性研究中,我们分析了 40 名 FMF 患者的 95 次妊娠。临床和人口统计学数据均来自患者的病历。为防止回忆偏差,我们仅对每位患者的最后一次妊娠进行了评估,以了解其疾病活动情况以及在妊娠期间使用或更换药物的情况。结果患者确诊时的中位年龄为 22 岁,首次妊娠年龄为 26 岁。最后一次怀孕时,FMF 的中位持续时间为 8(0-23)年。8名患者(20%)至少有一次通过辅助生殖技术(IVF)怀孕,34名患者(85%)至少有一次自然怀孕。32 名患者(80%)在怀孕前病情得到缓解,8 名患者(20%)病情处于临床活动期。妊娠期间,23 名患者(57.5%)的临床病程和发作频率有所改善,10 名患者(25.0%)的病程稳定,7 名患者(17.5%)的病情恶化。活产率为 70.0%,流产率为 28.9%,早产率为 8.1%,子痫前期为 5.0%,仅发现 1 例软骨发育不全为先天性胎儿畸形。妊娠过程中最重要的产科问题、并发症和胎儿不良结局是体外受精需求、流产和剖宫产率增加。FMF 本身或使用秋水仙碱不会增加先天性畸形的风险。
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引用次数: 0
Breakthroughs in women's health for treating vasomotor symptoms 妇女健康在治疗血管运动症状方面的突破
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.004
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引用次数: 0
Impact of colposcopy-guided carbon dioxide laser vaporization therapy on peripheral cervical intraepithelial neoplasia lesions 阴道镜引导下二氧化碳激光汽化疗法对宫颈上皮内瘤变周边病变的影响
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.06.012

Objective

Laser vaporization is less invasive than conization for cervical intraepithelial neoplasia (CIN). The outcome of laser vaporization for CIN is empirically known to depend on the colposcopic findings, especially localization of the lesion. In this study, we sought to identify factors involved in the outcome of laser vaporization.

Materials and methods

We retrospectively investigated 290 cases of CIN (CIN2, n = 180; CIN3, n = 110) treated with laser evaporation at Nishikawa Women's Health Clinic between 2018 and 2021. All treatments were performed using a carbon dioxide laser under either colposcopic vision (n = 172) or direct vision using a vaginal speculum (n = 118). Risk factors were statistically examined for cure rate after treatment.

Results

Multivariate analysis using a logistic regression model identified independent factors affecting the success of treatment to be high-risk human papillomavirus infection status preoperatively, CIN grade, presence of CIN lesions at the periphery of the cervix, and the surgical method used. Colposcopy-guided laser vaporization reduced the risk of treatment failure by 84% (odds ratio 0.16, 95% confidence interval 0.06–0.46; p = 0.001) compared with direct vision using a vaginal speculum. For lesions at the periphery of the cervix, most of the treatment failures were in the group that was not guided by colposcopy (p = 0.031).

Conclusion

The presence of a peripheral CIN lesion was suggested to be a risk factor for treatment failure. Laser vaporization under colposcopic vision is recommended for treatment of peripheral CIN lesions.
激光汽化术治疗宫颈上皮内瘤变(CIN)比锥切术创伤更小。根据经验,激光汽化术治疗 CIN 的效果取决于阴道镜检查结果,尤其是病灶的定位。在这项研究中,我们试图找出激光汽化治疗结果的相关因素。材料和方法我们回顾性调查了2018年至2021年期间在西川妇女健康诊所接受激光汽化治疗的290例CIN(CIN2,n = 180;CIN3,n = 110)。所有治疗均在阴道镜视野(n = 172)或阴道窥器直视(n = 118)下使用二氧化碳激光进行。结果使用逻辑回归模型进行多变量分析后发现,影响治疗成功的独立因素包括术前高危人乳头瘤病毒感染状况、CIN等级、宫颈外围是否存在CIN病变以及所使用的手术方法。与使用阴道窥器直视相比,阴道镜引导下的激光汽化术将治疗失败的风险降低了 84%(几率比 0.16,95% 置信区间 0.06-0.46;P = 0.001)。对于宫颈外围的病变,大多数治疗失败的病例都发生在没有阴道镜引导的组别中(p = 0.031)。建议在阴道镜视野下进行激光汽化治疗外周 CIN 病变。
{"title":"Impact of colposcopy-guided carbon dioxide laser vaporization therapy on peripheral cervical intraepithelial neoplasia lesions","authors":"","doi":"10.1016/j.tjog.2024.06.012","DOIUrl":"10.1016/j.tjog.2024.06.012","url":null,"abstract":"<div><h3>Objective</h3><div>Laser vaporization is less invasive than conization for cervical intraepithelial neoplasia (CIN). The outcome of laser vaporization for CIN is empirically known to depend on the colposcopic findings, especially localization of the lesion. In this study, we sought to identify factors involved in the outcome of laser vaporization.</div></div><div><h3>Materials and methods</h3><div>We retrospectively investigated 290 cases of CIN (CIN2, n = 180; CIN3, n = 110) treated with laser evaporation at Nishikawa Women's Health Clinic between 2018 and 2021. All treatments were performed using a carbon dioxide laser under either colposcopic vision (n = 172) or direct vision using a vaginal speculum (n = 118). Risk factors were statistically examined for cure rate after treatment.</div></div><div><h3>Results</h3><div>Multivariate analysis using a logistic regression model identified independent factors affecting the success of treatment to be high-risk human papillomavirus infection status preoperatively, CIN grade, presence of CIN lesions at the periphery of the cervix, and the surgical method used. Colposcopy-guided laser vaporization reduced the risk of treatment failure by 84% (odds ratio 0.16, 95% confidence interval 0.06–0.46; p = 0.001) compared with direct vision using a vaginal speculum. For lesions at the periphery of the cervix, most of the treatment failures were in the group that was not guided by colposcopy (p = 0.031).</div></div><div><h3>Conclusion</h3><div>The presence of a peripheral CIN lesion was suggested to be a risk factor for treatment failure. Laser vaporization under colposcopic vision is recommended for treatment of peripheral CIN lesions.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-level mosaic trisomy 21 at amniocentesis and cordocentesis in a pregnancy associated with a favorable fetal outcome and perinatal progressive decrease of the trisomy 21 cell line 羊膜穿刺术和脐带穿刺术中的低水平 21 三体综合征与良好的胎儿结局和围产期 21 三体综合征细胞系的逐渐减少有关
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.013

Objective

We present low-level mosaic trisomy 21 at amniocentesis and cordocentesis in a pregnancy associated with a favorable fetal outcome and perinatal progressive decrease of the trisomy 21 cell line.

Case Report

A 36-year-old, primigravid woman underwent amniocentesis at 16 weeks of gestation because of advanced maternal age. This pregnancy was conceived by in vitro fertilization and embryo transfer (IVF-ET). Amniocentesis revealed a karyotype of 47,XY,+21 [3]/46,XY [17] (15% mosaicism) and simultaneous array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes revealed the result of arr (21) × 2∼3 (X,Y) × 1, consistent with 24.5% mosaicism for trisomy 21. Cordocentesis performed at 21 weeks of gestation revealed a karyotype of 47,XY,+21 [3]/46,XY [37] (6% mosaicism). She was referred for genetic counseling at 31 weeks of gestation, and continuing the pregnancy was advised. The parental karyotypes and prenatal ultrasound were normal. At 37 weeks of gestation, a phenotypically normal baby was delivered with a body weight of 2900-g. The karyotypes of cord blood, umbilical cord and placenta were 47,XY,+21 [1]/46,XY [39] (2.5% mosaicism), 47,XY,+21 [10]/46,XY [30] (25% mosaicism) and 47,XY,+21 [22]/46,XY [18] (55% mosaicism), respectively. Quantitative fluorescent polymerase chain reaction (QF-PCR) analysis on the DNA extracted from umbilical cord and parental bloods excluded uniparental disomy (UPD) 21 and revealed a maternal origin of the extra chromosome 21. When follow-up at the age of 2 months, the neonate was normal in phenotype and development. The peripheral blood had a karyotype of 47,XY,+21 [1]/46,XY [39] (2.5% mosaicism), and interphase fluorescence in situ hybridization (FISH) analysis on uncultured buccal mucosal cells revealed 4.7% (5/105 cells) mosaicism for trisomy 21, compared with 0% (5/100 cells) in the normal control.

Conclusion

Low-level mosaic trisomy 21 at amniocentesis and cordocentesis can be associated with favorable fetal outcome and perinatal progressive decrease of the trisomy 21 cell line.
病例报告 一位 36 岁的初产妇因高龄而在妊娠 16 周时接受了羊膜腔穿刺术。该孕妇是通过体外受精和胚胎移植(IVF-ET)怀孕的。羊膜腔穿刺术显示核型为 47,XY,+21 [3]/46,XY [17](15%嵌合),同时对未培养羊膜细胞提取的 DNA 进行阵列比较基因组杂交(aCGH)分析,结果显示为 arr (21) × 2∼3 (X,Y) ×1,符合 24.5% 的 21 三体嵌合率。妊娠 21 周时进行的脊髓穿刺显示核型为 47,XY,+21 [3]/46,XY [37](6%嵌合)。她在妊娠 31 周时被转诊到遗传咨询中心,医生建议她继续妊娠。父母的核型和产前超声检查均正常。妊娠 37 周时,一名表型正常的婴儿出生,体重 2900 克。脐血、脐带和胎盘的核型分别为 47,XY,+21 [1]/46,XY [39](2.5%嵌合)、47,XY,+21 [10]/46,XY [30](25%嵌合)和 47,XY,+21 [22]/46,XY [18](55%嵌合)。对从脐带血和父母血液中提取的 DNA 进行定量荧光聚合酶链反应(QF-PCR)分析,排除了 21 号单亲裂殖症(UPD),并发现额外的 21 号染色体来自母体。在 2 个月大时进行的随访中,新生儿的表型和发育均正常。外周血核型为 47,XY,+21 [1]/46,XY [39](2.5%嵌合),对未培养的口腔粘膜细胞进行的间期荧光原位杂交(FISH)分析显示,4.结论在羊膜腔穿刺术和脐带穿刺术中发现的低水平嵌合型 21 三体综合征可能与胎儿预后良好和围产期 21 三体细胞系逐渐减少有关。
{"title":"Low-level mosaic trisomy 21 at amniocentesis and cordocentesis in a pregnancy associated with a favorable fetal outcome and perinatal progressive decrease of the trisomy 21 cell line","authors":"","doi":"10.1016/j.tjog.2024.09.013","DOIUrl":"10.1016/j.tjog.2024.09.013","url":null,"abstract":"<div><h3>Objective</h3><div>We present low-level mosaic trisomy 21 at amniocentesis and cordocentesis in a pregnancy associated with a favorable fetal outcome and perinatal progressive decrease of the trisomy 21 cell line.</div></div><div><h3>Case Report</h3><div>A 36-year-old, primigravid woman underwent amniocentesis at 16 weeks of gestation because of advanced maternal age. This pregnancy was conceived by <em>in vitro</em> fertilization and embryo transfer (IVF-ET). Amniocentesis revealed a karyotype of 47,XY,+21 [3]/46,XY [17] (15% mosaicism) and simultaneous array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes revealed the result of arr (21) × 2∼3 (X,Y) × 1, consistent with 24.5% mosaicism for trisomy 21. Cordocentesis performed at 21 weeks of gestation revealed a karyotype of 47,XY,+21 [3]/46,XY [37] (6% mosaicism). She was referred for genetic counseling at 31 weeks of gestation, and continuing the pregnancy was advised. The parental karyotypes and prenatal ultrasound were normal. At 37 weeks of gestation, a phenotypically normal baby was delivered with a body weight of 2900-g. The karyotypes of cord blood, umbilical cord and placenta were 47,XY,+21 [1]/46,XY [39] (2.5% mosaicism), 47,XY,+21 [10]/46,XY [30] (25% mosaicism) and 47,XY,+21 [22]/46,XY [18] (55% mosaicism), respectively. Quantitative fluorescent polymerase chain reaction (QF-PCR) analysis on the DNA extracted from umbilical cord and parental bloods excluded uniparental disomy (UPD) 21 and revealed a maternal origin of the extra chromosome 21. When follow-up at the age of 2 months, the neonate was normal in phenotype and development. The peripheral blood had a karyotype of 47,XY,+21 [1]/46,XY [39] (2.5% mosaicism), and interphase fluorescence <em>in situ</em> hybridization (FISH) analysis on uncultured buccal mucosal cells revealed 4.7% (5/105 cells) mosaicism for trisomy 21, compared with 0% (5/100 cells) in the normal control.</div></div><div><h3>Conclusion</h3><div>Low-level mosaic trisomy 21 at amniocentesis and cordocentesis can be associated with favorable fetal outcome and perinatal progressive decrease of the trisomy 21 cell line.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-level mosaic trisomy 21 due to mosaic unbalanced Robertsonian translocation of 46,XX,+21,der(21;21) (q10;q10)/46,XX at amniocentesis in a pregnancy associated with a favorable fetal outcome, cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, cytogenetic discrepancy among various tissues and perinatal progressive decrease of the trisomy 21 cell line 在一次妊娠中,羊膜腔穿刺时发现 46,XX,+21,der(21;21)(q10;q10)/46,XX 的罗伯逊不平衡易位导致低水平镶嵌式 21 三体综合征,胎儿结局良好;培养羊膜细胞和未培养羊膜细胞之间存在细胞遗传差异;各种组织之间存在细胞遗传差异;围产期 21 三体综合征细胞系逐渐减少
IF 2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-29 DOI: 10.1016/j.tjog.2024.09.014

Objective

We present prenatal diagnosis of mosaic trisomy 21 at amniocentesis associated with unbalanced Robertsonian translocation in the fetus and a favorable fetal outcome.

Case Report

A 41-year-old, primigravid woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Her husband was 41 years old. Amniocentesis revealed a karyotype of 46,XX,+21,der(21;21) (q10;q10)[8]/46,XX[18], consistent with 30.8% (8/26 colonies) mosaicism for trisomy 21. Simultaneous array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes revealed the result of arr (1–22,X) × 2 with no genomic imbalance. Repeat amniocentesis at 21 weeks of gestation revealed a karyotype of 46,XX,+21,der(21;21) (q10;q10)[2]/46,XX[25], consistent with 7.4% (2/27 colonies) mosaicism for trisomy 21. Cord blood sampling revealed the result of 46,XX and rsa X(P095) × 2, 13,18,21(P095) × 2. Prenatal ultrasound findings were normal. At 23 weeks of gestation, she underwent cord blood sampling which revealed a karyotype of 46,XX. At 26 weeks of gestation, she was referred for genetic counseling. No repeat amniocentesis and continuing the pregnancy were advised. The mother had a karyotype of 46,XX, and the father had a karyotype of 46,XY. At 38 weeks of gestation, a 3476-g, phenotypically normal baby was delivered. The cord blood had a karyotype of 46,XX,+21,der(21;21) (q10;q10)[1]/46,XX[39] (2.5% mosaicism). The placenta had a karyotype of 46,XX,+21,der(21;21) (q10;q10) (40/40 cells). When follow-up at age two months, the neonate was normal in phenotype and development. The peripheral blood had a karyotype of 46,XX (40/40 cells), and aCGH analysis on buccal mucosal cells resulted no genomic imbalance.

Conclusion

Low-level mosaic trisomy 21 at amniocentesis due to mosaic unbalanced Robertsonian translocation with a normal cell line can be associated with a favorable fetal outcome, cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, cytogenetic discrepancy among various tissues and perinatal progressive decrease of the trisomy 21 cell line.
病例报告 一位 41 岁的初产妇因高龄而在妊娠 17 周时接受了羊膜腔穿刺术。她的丈夫 41 岁。羊水穿刺显示核型为 46,XX,+21,der(21;21)(q10;q10)[8]/46,XX[18],与 30.8%(8/26 例)的 21 三体嵌合相符。同时对未培养羊膜细胞提取的 DNA 进行阵列比较基因组杂交(aCGH)分析,结果显示为 arr (1-22,X) × 2,无基因组失衡。妊娠 21 周时再次进行羊膜腔穿刺,发现核型为 46,XX,+21,der(21;21)(q10;q10)[2]/46,XX[25],与 7.4%(2/27 个菌落)的 21 三体嵌合情况一致。脐带血取样显示结果为 46,XX 和 rsa X(P095) ×2、13,18,21(P095) ×2。妊娠 23 周时,她接受了脐带血采样,结果显示核型为 46,XX。妊娠 26 周时,她被转介到遗传咨询中心。医生建议她不要再次进行羊水穿刺,并继续妊娠。母亲的核型为 46,XX,父亲的核型为 46,XY。妊娠 38 周时,一个重 3476 克、表型正常的婴儿娩出。脐带血核型为 46,XX,+21,der(21;21)(q10;q10)[1]/46,XX[39](2.5% 嵌合)。胎盘核型为 46,XX,+21,der(21;21)(q10;q10)(40/40 个细胞)。两个月大时进行随访,新生儿的表型和发育均正常。外周血核型为 46,XX(40/40 个细胞),口腔粘膜细胞的 aCGH 分析结果显示没有基因组失衡。结论羊膜腔穿刺术中由于罗伯逊不平衡易位导致的低水平镶嵌式 21 三体综合征与正常细胞系、培养的羊膜细胞与未培养的羊膜细胞之间的细胞遗传差异、各种组织之间的细胞遗传差异以及围生期 21 三体细胞系的逐渐减少有关。
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引用次数: 0
期刊
Taiwanese Journal of Obstetrics & Gynecology
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