Taiwanese Journal of Obstetrics & Gynecology最新文献

{"title":"Completeness of interval cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for advanced epithelial ovarian cancer","authors":"Peng-Hui Wang, Brahmana Askandar Tjokroprawiro, Ming-Shyen Yen","doi":"10.1016/j.tjog.2025.09.019","DOIUrl":"10.1016/j.tjog.2025.09.019","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 941-943"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and neonatal outcomes in primary vs. secondary meconium-stained amniotic fluid","authors":"Haya Hebi ,&nbsp;Lilian Haj ,&nbsp;Rudi Hamoudi ,&nbsp;Raneen Sawaid Kayal ,&nbsp;Ala Aiob ,&nbsp;Lior Lowenstein ,&nbsp;Inshirah Sgayer","doi":"10.1016/j.tjog.2025.06.004","DOIUrl":"10.1016/j.tjog.2025.06.004","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to compare obstetrical and neonatal outcomes between women with primary meconium-stained amniotic fluid (MSAF), which presents at membrane rupture, and women with secondary MSAF, which appears after rupture of initially clear fluid.</div></div><div><h3>Material and methods</h3><div>This retrospective cohort study included all singleton deliveries at ≥37 weeks gestation with MSAF, at a tertiary university-affiliated hospital between March 2020 and July 2024. Multiple pregnancies, preterm deliveries and elective cesarean deliveries (CD) were excluded. The primary outcome was a composite of adverse neonatal events, including low Apgar scores, umbilical artery pH &lt; 7.15, admission to the neonatal intensive care unit, meconium aspiration syndrome, and neonatal death.</div></div><div><h3>Results</h3><div>Of 2142 women with MSAF, 128 (6 %) had secondary MSAF. Secondary compared to primary MSAF was associated with higher rates of CD (26.6 % vs 14.9 %, p &lt; 0.001), CD due to fetal distress (24.2 % vs. 12.9 %, p = 0.001), operative deliveries (7.8 % vs. 3.8 %, p &lt; 0.001), admission to the neonatal intensive care unit (8.6 % vs. 3.4 %, p = 0.007), and respiratory support (7.0 % vs. 3.0 %, p = 0.034). The composite adverse neonatal outcome was more frequent following secondary MSAF (30.5 % vs 15.7 %, p &lt; 0.001), particularly in deliveries beyond 40 weeks (40.0 % vs. 22.1 %, p = 0.035). In multivariate analysis, secondary MSAF was an independent risk factor for the composite adverse neonatal outcome (odds ratio 1.73, 95 % CI = 1.13–2.67, p = 0.012) after adjustment for potential confounders.</div></div><div><h3>Conclusion</h3><div>Compared to primary MSAF, secondary MSAF, especially after 40 weeks of gestation was associated with worse neonatal outcomes. This supports the role of secondary MSAF as a potential marker of adverse neonatal outcomes.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1004-1008"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-level mosaic trisomy 9 at amniocentesis in a pregnancy with a positive non-invasive prenatal testing result for trisomy 9, intrauterine growth restriction, cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 9 cell line and a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.09.013","DOIUrl":"10.1016/j.tjog.2025.09.013","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1116-1119"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follow-up of a 4-year-old girl with a favorable outcome and a prenatal history of low-level mosaic trisomy 9 at amniocentesis","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.09.014","DOIUrl":"10.1016/j.tjog.2025.09.014","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Page 1120"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of long-read sequencing to delineate a rare large deletion of beta-globin gene which escaped Sanger sequencing at prenatal diagnosis in a family clustered with hereditary persistence of fetal hemoglobin","authors":"Dong-Jay Lee ,&nbsp;Shun-Ping Chang ,&nbsp;Min-Jun Liao ,&nbsp;Mei-Hui Lee ,&nbsp;Wen-Hsiang Lin ,&nbsp;Po-Chien Chen ,&nbsp;Po-Yeh Chen ,&nbsp;Yi-Shing Lin ,&nbsp;Gwo-Chin Ma ,&nbsp;Ming Chen","doi":"10.1016/j.tjog.2025.04.022","DOIUrl":"10.1016/j.tjog.2025.04.022","url":null,"abstract":"<div><h3>Objective</h3><div>Thalassemias, including alpha and beta thalassemia, are the most common monogenic inherited Mendelian disorder in Taiwan. The mutation spectrums of alpha and beta thalassemia are well known in the Taiwanese population. Among them, mutations with the format of large deletions are more prevalent in alpha thalassemia whereas point mutations or small insertion/deletions (indels) are much more prevalent in beta thalassemia. Hereditary persistence of fetal hemoglobin (HPFH), a clinical subtype of beta thalassemia, is a relative uncommon condition during prenatal diagnosis in the Taiwanese population, most often caused by large deletions and may escape diagnostic panels based on Sanger sequencing. This study aimed to explore the feasibility of third-generation long read sequencing (LRS) in the genetic diagnosis of such rare condition in a prenatal setting.</div></div><div><h3>Case report</h3><div>A woman at her second trimester pregnancy went to our hospital due to a high suspicion was impressed that both she and her husband were carriers of beta thalassemia by their primary care obstetricians. Due to time constraint in a prenatal setting, the blood samples of both couple and the fetal sample (obtained through amniocentesis) were simultaneously taken and genotyping of beta-globin gene was performed in the family trio. Beta-globin gene sequencing together with karyotyping and chromosome microarray were conducted in the fetal sample (amniotic fluid). Initial results by Sanger sequencing-based molecular diagnostics for beta-globin gene only depict the maternal mutation allele whereas a large deletion of the beta-globin gene may be hidden in the fetus and the father with unknown size was suspected from the chromosome microarray result. LRS therefore was performed and a very rare 27411-bp deletion was noted both in the fetus and the father, and further confirmed by the methodologies based upon polymerase chain reaction (PCR).</div></div><div><h3>Conclusion</h3><div>LRS can aid in the prenatal diagnosis of rare conditions like HPFH, given the current practice that Sanger sequencing-based molecular diagnostic platform is utilized here in Taiwan as first-line for beta thalassemia. Meanwhile, high resolution chromosome microarray, like the oligonucleotide array comparative genomic hybridization in this study, can also aid in the genetic diagnosis of deletion-type beta thalassemia, despite the actual size and breakpoints of the deletion may only be delineated by LRS in a straight-forward fashion, and can be further verified with traditional PCR-based methodologies.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1080-1084"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herniated intervertebral disc induced cauda equina syndrome during pregnancy: Case report and literature review","authors":"Yi-Min Chen ,&nbsp;Yueh-Han Ku ,&nbsp;Tsung-Ho Ying ,&nbsp;Su-Ju Tsai","doi":"10.1016/j.tjog.2024.08.017","DOIUrl":"10.1016/j.tjog.2024.08.017","url":null,"abstract":"<div><h3>Objective</h3><div>Herniated intervertebral disc (HIVD) has long been a common cause of lower back pain. When complicated with cauda equina syndrome and neurological symptoms, HIVD remains a surgical indication to release compressive stress. However, for pregnant female patients, it poses a huge dilemma regarding preterm delivery, as the increasing fetal body weight may burden the mother's spinal condition.</div></div><div><h3>Case report</h3><div>We present a case of a 27-year-old female diagnosed with HIVD complicated with cauda equina syndrome while pregnant in the second trimester. She underwent spinal decompression surgery during pregnancy and was under following rehabilitation and intensive prenatal examinations. Cesarean section delivery was performed under the situation of preterm labor at 35 weeks of pregnancy.</div></div><div><h3>Conclusion</h3><div>Surgical decompression is necessary for pregnant patients with a combination of HIVD and cauda equina syndrome, followed by intensive monitoring of the fetal growth and delivery via cesarean section.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1061-1064"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete mole with co-existing fetus: a rare case report of full-term delivery with favorable maternal and fetal outcomes","authors":"Hu Liuqin ,&nbsp;Wang Na ,&nbsp;Zhang Huimin ,&nbsp;Li Shaoying ,&nbsp;Xie Yinong ,&nbsp;Yuan Zhiguang ,&nbsp;Chen min ,&nbsp;Li Yingtao ,&nbsp;Li Zhihua ,&nbsp;Chen Dunjin","doi":"10.1016/j.tjog.2024.07.026","DOIUrl":"10.1016/j.tjog.2024.07.026","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the obstetric and oncological outcomes of CHMCF and to give a beneficial reference for the individualized management of the disease and the timing of pregnancy termination.</div></div><div><h3>Case report</h3><div>A 25-year-old primipara was diagnosed with CHMCF at 17 weeks of gestation by prenatal ultrasound. Magnetic resonance imaging, genetics and consanguinity identification testing were performed. There were no serious pregnancy complications. At 38 weeks of gestation, a small-for-gestational-age fetus was delivered by cesarean section, and there was no obvious abnormality in postpartum follow-up.</div></div><div><h3>Conclusion</h3><div>CHMCF belongs to paternal diploid twin pregnancy. Ultrasound and magnetic resonance imaging are important methods for early diagnosis. When the fetal karyotype is normal and there is no obvious pregnancy complication, it is feasible to continue pregnancy, and the incidence of GTN is not significantly increased compared with the termination of pregnancy.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1056-1060"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosaic interstitial 2q deletion or 46,XY,del(2)(q21q33)t(5;7)(q13.1;q21)/46,XY at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, a normal karyotype at birth and a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.09.010","DOIUrl":"10.1016/j.tjog.2025.09.010","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1104-1105"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal diagnosis of a de novo 3p22.3p21.3 duplication associated with 46,XX,der(16)ins(16;3) (q22;p22.3p21.31) in a pregnancy","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.09.004","DOIUrl":"10.1016/j.tjog.2025.09.004","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1087-1090"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of autologous hematopoietic stem cell transplantation on female fertility in multiple sclerosis: A systemic review and meta-analysis","authors":"Anusha Ashkar ,&nbsp;Shayan A. Irfan ,&nbsp;Fatima Siddiqui ,&nbsp;Mirza Mehmood Ali Baig ,&nbsp;Saba Shah","doi":"10.1016/j.tjog.2025.06.003","DOIUrl":"10.1016/j.tjog.2025.06.003","url":null,"abstract":"<div><div>This research was conducted to determine the effect of autologous hematopoietic stem cell transplantation (AHSCT) on female fertility in multiple sclerosis (MS). PubMed, Scopus, Google Scholar, and the Cochrane Library were searched using the search string: (multiple sclerosis OR MS) AND (AHSCT OR Autologous hematopoietic stem cell transplantation) AND (pregnancy OR pregnant OR conception OR conceive OR gestation∗). Only those studies that involved AHSCT in MS female patients were included in the study. All statistical analyses were conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. The random-effects model was used to calculate the Inverse Variance (IV) and its corresponding 95 % confidence interval (CI). Moreover, qualitative analysis was conducted to analyze anti-Mullerian hormone level (AMH), amenorrheic status, restoration of menstruation, pregnancy outcome, and mode of delivery post-AHSCT. Four cohorts were used in the study. The prevalence of pregnancy was reported as 10 % (95 % CI = 4–17 %, I² = 20 %). Qualitative analysis reports a positive correlation between the restoration of normal menses, live birth, and normal vaginal delivery with AHSCT, while a negative correlation is reported between AMH, amenorrhea, abortion, and cesarean section with AHSCT. Our systematic review and meta-analysis are the first to demonstrate an effect of AHSCT on female fertility in MS patients; however, small sample size and limited number of studies are the main limiting factors. Further studies are needed to strengthen the findings of our study.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 951-956"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}