Pub Date : 2024-07-01DOI: 10.1016/j.tjog.2024.05.004
Peng-Hui Wang, Szu-Ting Yang, Chia-Hao Liu
{"title":"The selection of immune checkpoint inhibitors of programmed cell death (anti-PD-1) and its ligand (anti-PD-L1) makes matters more challenges for clinical practice","authors":"Peng-Hui Wang, Szu-Ting Yang, Chia-Hao Liu","doi":"10.1016/j.tjog.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.05.004","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001189/pdfft?md5=ea06a113d546c0ec1181b19f95a9556b&pid=1-s2.0-S1028455924001189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.tjog.2024.04.011
Xia Gao , Mingxia Xie , Echo Xu , Tou Tou , Fangfang Liu
{"title":"Prenatal diagnosis and genetic counseling of 45,X/46,XX low-level mosaicism with a favorable outcome","authors":"Xia Gao , Mingxia Xie , Echo Xu , Tou Tou , Fangfang Liu","doi":"10.1016/j.tjog.2024.04.011","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.04.011","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001463/pdfft?md5=b70be0074172f07ff1623193212534af&pid=1-s2.0-S1028455924001463-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.tjog.2023.12.003
Fang Chen , Dong-Zhi Li
{"title":"Achondrogenesis type 1B: The need for clinical vigilance in the first trimester fetus with cystic hygroma and micromelic limbs","authors":"Fang Chen , Dong-Zhi Li","doi":"10.1016/j.tjog.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.tjog.2023.12.003","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001451/pdfft?md5=f24276dc7e2849b9dea64cdd331a641a&pid=1-s2.0-S1028455924001451-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to “optimal gestational weight gain in Taiwan: A retrospective cohort study”","authors":"Fu-Ching Chuang, Hsin-Yin Huang, Yu-Hao Chen, Jian-Pei Huang","doi":"10.1016/j.tjog.2024.04.012","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.04.012","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001475/pdfft?md5=8a1b2cccd7a9fcbc1a46d00e6c267e64&pid=1-s2.0-S1028455924001475-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.tjog.2024.02.006
Honglei Duan , Wanjun Wang , Ying Zhang , Xuemei Chen , Zihan Jiang , Jie Li
Objective
To evaluate the accuracy of expanded noninvasive prenatal testing (NIPT) for maternal copy number variations.
Materials and methods
Expanded NIPT was used to detect CNVs ≥2 Mb at a whole-genome scale. The threshold of maternal deletion was copy numbers (CN) ≤ 1.6, and the threshold of maternal duplication was CN ≥ 2.4.
Results
Of the 5440 pregnant women with successful expanded NIPT results, 28 maternal CNVs ≥2 Mb were detected in 27 pregnant women. Except for five cases reported as test failure, 23 CNVs ≥2 Mb were confirmed among the remaining 22 pregnant women by CNV-seq of maternal lymphocyte DNA. The genomic location, copy numbers and fragment size of maternal CNVs reported by expanded NIPT were consistent with the results of CNV-seq of maternal lymphocyte DNA.
Conclusions
Maternal CNVs ≥2 Mb can be accurately evaluated according to the CN indicated by expanded NIPT results.
{"title":"Accuracy of expanded noninvasive prenatal testing for maternal copy number variations: A comparative study with CNV-seq of maternal lymphocyte DNA","authors":"Honglei Duan , Wanjun Wang , Ying Zhang , Xuemei Chen , Zihan Jiang , Jie Li","doi":"10.1016/j.tjog.2024.02.006","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.02.006","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the accuracy of expanded noninvasive prenatal testing (NIPT) for maternal copy number variations.</p></div><div><h3>Materials and methods</h3><p>Expanded NIPT was used to detect CNVs ≥2 Mb at a whole-genome scale. The threshold of maternal deletion was copy numbers (CN) ≤ 1.6, and the threshold of maternal duplication was CN ≥ 2.4.</p></div><div><h3>Results</h3><p>Of the 5440 pregnant women with successful expanded NIPT results, 28 maternal CNVs ≥2 Mb were detected in 27 pregnant women. Except for five cases reported as test failure, 23 CNVs ≥2 Mb were confirmed among the remaining 22 pregnant women by CNV-seq of maternal lymphocyte DNA. The genomic location, copy numbers and fragment size of maternal CNVs reported by expanded NIPT were consistent with the results of CNV-seq of maternal lymphocyte DNA.</p></div><div><h3>Conclusions</h3><p>Maternal CNVs ≥2 Mb can be accurately evaluated according to the CN indicated by expanded NIPT results.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001311/pdfft?md5=2a64308e8884a8983046e01f0fa2f98f&pid=1-s2.0-S1028455924001311-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.tjog.2024.05.012
Chih-Ping Chen , Shin-Yu Lin , Ti-Jia Yuan
{"title":"Application of array comparative genomic hybridization on the DNA extracted from cultured amniocytes for rapid diagnosis of 22q11.2 microdeletion in a pregnancy with a normal karyotype at amniocentesis and double outlet right ventricle and transposition of great arteries on level II ultrasound","authors":"Chih-Ping Chen , Shin-Yu Lin , Ti-Jia Yuan","doi":"10.1016/j.tjog.2024.05.012","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.05.012","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001396/pdfft?md5=ad6c71a7b92aecca7068dc3469a4aad0&pid=1-s2.0-S1028455924001396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breast cancer is the most frequently diagnosed cancer among women worldwide. Mortality-to-incidence ratio (MIR) is a marker that reflects the efficacy and availability of screening interventions and treatment outcomes. MIR can be used to influence public health strategy. The association between the MIRs for breast cancer among countries with different economic statuses and health expenditure is important yet has been investigated. This study was aimed to elucidate the association between the breast cancer MIRs and the human development and health expenditure among different countries.
Materials and methods
Cancer incidence and mortality rates were obtained from the GLOBOCAN database. The MIRs were calculated by dividing the crude rate of mortality to the incidence. Associations among the MIR and variants of human development index (HDI) and current health expenditure (CHE) in 50 countries were estimated via linear regression.
Results
Breast cancer had a higher incidence rate, but lower mortality rate, in developed countries (high HDI, CHE per capita, CHE/GDP), as compared with developing countries. Favorable MIRs were associated with a high HDI and high health expenditure countries (presented by high CHE per capita, and CHE/GDP) (both p < 0.001)
Conclusion
The MIR for breast cancer is reversely correlated with the development and healthcare disparities among different countries. This implies that allocating more resources to healthcare systems for breast cancer screening and treatment can improve disease outcomes. Our report may be helpful for public health policy making.
目标乳腺癌是全球妇女中最常确诊的癌症。死亡率与发病率之比（MIR）是反映筛查干预措施的有效性和可用性以及治疗效果的指标。死亡率与发病率比可用于影响公共卫生策略。不同经济状况的国家之间乳腺癌死亡率与发病率之间的关系和医疗支出之间的关系非常重要，但尚未进行过调查。本研究旨在阐明不同国家的乳腺癌中位数与人类发展和卫生支出之间的关联。通过将粗死亡率除以发病率计算出乳腺癌中位数。结果与发展中国家相比，发达国家（高人类发展指数、人均医疗支出、医疗支出/国内生产总值）的乳腺癌发病率较高，但死亡率较低。高人类发展指数和高医疗支出国家（表现为高人均医疗费用和高医疗费用/国内生产总值）与有利的乳腺癌发病率与死亡率中位数相关（均为 p < 0.001）。这意味着向医疗系统分配更多资源用于乳腺癌筛查和治疗可以改善疾病的预后。我们的报告可能有助于公共卫生政策的制定。
{"title":"Favorable breast cancer mortality-to-incidence ratios of countries with good human development index rankings and high health expenditures","authors":"Chia-Yu Chou , Tzu-Tsen Shen , Wen-Ching Wang , Ming-Ping Wu","doi":"10.1016/j.tjog.2023.11.012","DOIUrl":"https://doi.org/10.1016/j.tjog.2023.11.012","url":null,"abstract":"<div><h3>Objective</h3><p>Breast cancer is the most frequently diagnosed cancer among women worldwide. Mortality-to-incidence ratio (MIR) is a marker that reflects the efficacy and availability of screening interventions and treatment outcomes. MIR can be used to influence public health strategy. The association between the MIRs for breast cancer among countries with different economic statuses and health expenditure is important yet has been investigated. This study was aimed to elucidate the association between the breast cancer MIRs and the human development and health expenditure among different countries.</p></div><div><h3>Materials and methods</h3><p>Cancer incidence and mortality rates were obtained from the GLOBOCAN database. The MIRs were calculated by dividing the crude rate of mortality to the incidence. Associations among the MIR and variants of human development index (HDI) and current health expenditure (CHE) in 50 countries were estimated via linear regression.</p></div><div><h3>Results</h3><p>Breast cancer had a higher incidence rate, but lower mortality rate, in developed countries (high HDI, CHE per capita, CHE/GDP), as compared with developing countries. Favorable MIRs were associated with a high HDI and high health expenditure countries (presented by high CHE per capita, and CHE/GDP) (both p < 0.001)</p></div><div><h3>Conclusion</h3><p>The MIR for breast cancer is reversely correlated with the development and healthcare disparities among different countries. This implies that allocating more resources to healthcare systems for breast cancer screening and treatment can improve disease outcomes. Our report may be helpful for public health policy making.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001293/pdfft?md5=da5e4f9846fef5b467f59238c01467b0&pid=1-s2.0-S1028455924001293-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.tjog.2024.05.009
Chih-Ping Chen , Fang-Tzu Wu , Yen-Ting Pan , Peih-Shan Wu , Chien-Wen Yang , Chien-Ling Chiu , Wayseen Wang
Objective
We present low-level mosaic trisomy at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 7 cell line and a favorable fetal outcome.
Case Report
A 40-year-old, primigravid woman underwent amniocentesis at 16 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 46,XY in cultured amniocytes. Simultaneous array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes revealed the result of arr (7) × 2–3, (X,Y) × 1, consistent with 24% mosaicism for trisomy 7. Polymorphic DNA marker analysis on the DNA extracted from the uncultured amniocytes and parental bloods excluded uniparental disomy (UPD) 7. Prenatal ultrasound findings were normal. She was referred for genetic counseling at 19 weeks of gestation. No repeat amniocentesis was suggested, and continuing the pregnancy was advised. At 22 weeks of gestation, the result of soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) = 6.1 (normal < 38). She did not have preeclampsia. At 39 weeks of gestation, a 3346-g male baby was delivered without any phenotypic abnormality. aCGH analysis on the DNA extracted from cord blood and placenta revealed the result of arr (1–22) × 2, (X,Y) × 1 with no genomic imbalance in all tissues. When follow-up at age three months, the baby was normal in development and phenotype. The peripheral blood had a karyotype of 46,XY, and interphase fluorescence in situ hybridization (FISH) analysis using the bacterial artificial chromosome (BAC) probes of chromosome 7 showed disomy 7 cells in all 102/102 cells.
Conclusion
Low-level mosaic trisomy 7 at amniocentesis can be associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 7 cell line and a favorable fetal outcome.
{"title":"Low-level mosaic trisomy 7 at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 7 cell line and a favorable fetal outcome","authors":"Chih-Ping Chen , Fang-Tzu Wu , Yen-Ting Pan , Peih-Shan Wu , Chien-Wen Yang , Chien-Ling Chiu , Wayseen Wang","doi":"10.1016/j.tjog.2024.05.009","DOIUrl":"https://doi.org/10.1016/j.tjog.2024.05.009","url":null,"abstract":"<div><h3>Objective</h3><p>We present low-level mosaic trisomy at amniocentesis in a pregnancy associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 7 cell line and a favorable fetal outcome.</p></div><div><h3>Case Report</h3><p>A 40-year-old, primigravid woman underwent amniocentesis at 16 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 46,XY in cultured amniocytes. Simultaneous array comparative genomic hybridization (aCGH) analysis on the DNA extracted from uncultured amniocytes revealed the result of arr (7) × 2–3, (X,Y) × 1, consistent with 24% mosaicism for trisomy 7. Polymorphic DNA marker analysis on the DNA extracted from the uncultured amniocytes and parental bloods excluded uniparental disomy (UPD) 7. Prenatal ultrasound findings were normal. She was referred for genetic counseling at 19 weeks of gestation. No repeat amniocentesis was suggested, and continuing the pregnancy was advised. At 22 weeks of gestation, the result of soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) = 6.1 (normal < 38). She did not have preeclampsia. At 39 weeks of gestation, a 3346-g male baby was delivered without any phenotypic abnormality. aCGH analysis on the DNA extracted from cord blood and placenta revealed the result of arr (1–22) × 2, (X,Y) × 1 with no genomic imbalance in all tissues. When follow-up at age three months, the baby was normal in development and phenotype. The peripheral blood had a karyotype of 46,XY, and interphase fluorescence <em>in situ</em> hybridization (FISH) analysis using the bacterial artificial chromosome (BAC) probes of chromosome 7 showed disomy 7 cells in all 102/102 cells.</p></div><div><h3>Conclusion</h3><p>Low-level mosaic trisomy 7 at amniocentesis can be associated with cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 7 cell line and a favorable fetal outcome.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001347/pdfft?md5=728674abe746767e437c54106f927f90&pid=1-s2.0-S1028455924001347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.tjog.2023.09.026
Siou-Ting Lee , Yi-Liang Lee , Ya-Che Chen , Wei Lin , Ching-I Wu , Chi-Kang Lin
Objective
Cerebral arteriovenous malformation during pregnancy is rare but lethal disease that usually present with new-onset seizures and headaches mimicking eclampsia. We report a rare case of cerebral arteriovenous malformation with abrupt seizures in the third trimester.
Case Report
A 28-year-old primipara was brought to our emergency department at 32 6/7 weeks of gestation with new-onset acute seizures and hypertension. Owing to neurological deterioration, the patient underwent emergency cesarean delivery. However, 24 h after cesarean delivery and eclampsia treatment, the seizures worsened. Computed tomography and magnetic resonance imaging showed unruptured arteriovenous malformation of the right frontal lobe. Subsequently, intraarterial embolization was performed. The patient was discharged 5 days after surgery without neurological sequelae or obstetric complications.
Conclusion
This case report highlights the differential diagnoses of sudden new-onset seizures in late pregnancy for obstetricians and emergency medicine physicians. Lethal cerebral diseases, apart from eclampsia, should be considered during pregnancy.
{"title":"Arteriovenous malformation-related headache and seizures in pregnancy masquerading as eclampsia: A case report","authors":"Siou-Ting Lee , Yi-Liang Lee , Ya-Che Chen , Wei Lin , Ching-I Wu , Chi-Kang Lin","doi":"10.1016/j.tjog.2023.09.026","DOIUrl":"https://doi.org/10.1016/j.tjog.2023.09.026","url":null,"abstract":"<div><h3>Objective</h3><p>Cerebral arteriovenous malformation during pregnancy is rare but lethal disease that usually present with new-onset seizures and headaches mimicking eclampsia. We report a rare case of cerebral arteriovenous malformation with abrupt seizures in the third trimester.</p></div><div><h3>Case Report</h3><p>A 28-year-old primipara was brought to our emergency department at 32 6/7 weeks of gestation with new-onset acute seizures and hypertension. Owing to neurological deterioration, the patient underwent emergency cesarean delivery. However, 24 h after cesarean delivery and eclampsia treatment, the seizures worsened. Computed tomography and magnetic resonance imaging showed unruptured arteriovenous malformation of the right frontal lobe. Subsequently, intraarterial embolization was performed. The patient was discharged 5 days after surgery without neurological sequelae or obstetric complications.</p></div><div><h3>Conclusion</h3><p>This case report highlights the differential diagnoses of sudden new-onset seizures in late pregnancy for obstetricians and emergency medicine physicians. Lethal cerebral diseases, apart from eclampsia, should be considered during pregnancy.</p></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924001359/pdfft?md5=ca45806bf616eb0df4c7d55a0450e55e&pid=1-s2.0-S1028455924001359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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