Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.08.006
Yumi Shimizu, Yuri Hamada, Takeshi Murakoshi
Objective
To present a case of total intestinal aganglionosis (TIA), which is the rarest form of Hirschsprung disease (HD) and is difficult to diagnose prenatally owing to nonspecific prenatal ultrasound findings.
Case report
In a 34-year-old primipara with a history of HD (total colonic aganglionosis), intestinal dilatation with intestinal movement like peristalsis was observed in the fetus starting at 36 weeks of gestation. By 38 weeks of gestation, the fetal abdominal circumference had increased, prompting cesarean section delivery. Prenatal ultrasound and postnatal barium enema findings suggested small intestinal obstruction, and the infant underwent laparotomy. However, HD was suspected based on the small intestinal dilatation associated with caliber changes. A full-layer biopsy from the dilated small intestine to the stomach revealed no ganglion cells, leading to a diagnosis of TIA.
Conclusion
Prenatal ultrasonography may reveal fetal intestinal dilatation with intestinal movement like peristalsis in HD, even in the aganglionic portion.
{"title":"A case of Hirschsprung disease of total intestinal aganglionosis with intestinal dilatation and peristalsis on prenatal ultrasound","authors":"Yumi Shimizu, Yuri Hamada, Takeshi Murakoshi","doi":"10.1016/j.tjog.2025.08.006","DOIUrl":"10.1016/j.tjog.2025.08.006","url":null,"abstract":"<div><h3>Objective</h3><div>To present a case of total intestinal aganglionosis (TIA), which is the rarest form of Hirschsprung disease (HD) and is difficult to diagnose prenatally owing to nonspecific prenatal ultrasound findings.</div></div><div><h3>Case report</h3><div>In a 34-year-old primipara with a history of HD (total colonic aganglionosis), intestinal dilatation with intestinal movement like peristalsis was observed in the fetus starting at 36 weeks of gestation. By 38 weeks of gestation, the fetal abdominal circumference had increased, prompting cesarean section delivery. Prenatal ultrasound and postnatal barium enema findings suggested small intestinal obstruction, and the infant underwent laparotomy. However, HD was suspected based on the small intestinal dilatation associated with caliber changes. A full-layer biopsy from the dilated small intestine to the stomach revealed no ganglion cells, leading to a diagnosis of TIA.</div></div><div><h3>Conclusion</h3><div>Prenatal ultrasonography may reveal fetal intestinal dilatation with intestinal movement like peristalsis in HD, even in the aganglionic portion.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 123-125"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.005
Chih-Ping Chen
{"title":"Mosaic distal 11q deletion or 46,XY,del(11)(q23)/46, XY at amniocentesis and cordocentesis in a pregnancy associated with perinatal progressive decrease of the aneuploid cell line and a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.005","DOIUrl":"10.1016/j.tjog.2025.11.005","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 129-130"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.006
Chih-Ping Chen
{"title":"Mosaicism for 47,XXX or 47,XXX/46,XX at amniocentesis in a pregnancy with a favorable outcome and no prominent perinatal decrease of the 47,XXX cell line","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.006","DOIUrl":"10.1016/j.tjog.2025.11.006","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 131-133"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.10.001
Peng-Hui Wang , Brahmana Askandar Tjokroprawiro , Jae-Weon Kim
{"title":"The role of secondary cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for treating recurrent ovarian cancer","authors":"Peng-Hui Wang , Brahmana Askandar Tjokroprawiro , Jae-Weon Kim","doi":"10.1016/j.tjog.2025.10.001","DOIUrl":"10.1016/j.tjog.2025.10.001","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 1-3"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tjog.2025.09.011
Chih-Ping Chen , Shin-Yu Lin , Fang-Tzu Wu , Yen-Ting Pan , Wayseen Wang
{"title":"High-level mosaic trisomy 9 at amniocentesis in a pregnancy associated with intrauterine growth restriction, a positive non-invasive prenatal testing for trisomy 9, cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, perinatal progressive decrease of the trisomy 9 cell line, a heterozygous missense mutation of the PIEZO2 gene and an adverse fetal outcome","authors":"Chih-Ping Chen , Shin-Yu Lin , Fang-Tzu Wu , Yen-Ting Pan , Wayseen Wang","doi":"10.1016/j.tjog.2025.09.011","DOIUrl":"10.1016/j.tjog.2025.09.011","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1106-1111"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tjog.2025.04.019
Yu-Kwang Lee , Chen-Yang Hsu , Ming-Yang Wang , Wen-Hung Kuo , Huang-Chun Lien , Yi-Hsuan Lee , Chiao Lo , Chiun-Sheng Huang
Objective
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Prognostic factors for TNBC are still inconclusive due to its heterogeneity. Neutrophil-to-lymphocyte ratio (NLR) has been reported as a valuable and cost effective prognostic tool for breast cancer patients. In this study, we aim to identify the prognostic factors for TNBC with a focus on NLR.
Materials and methods
We retrospectively analyzed stage I-III TNBC patients receiving upfront operation at National Taiwan University Hospital (NTUH) between January 2015 and December 2021. Age, tumor size, lymph node metastasis, cancer stage, histologic grade, lymphovascular invasion, perineural invasion, Ki67 levels, and neutrophil-to-lymphocyte ratio (NLR) were analyzed as prognostic factors. We used 3.4 as the cutoff point for NLR.
Results
We identified 248 stage I-III patients, the overall 5-year disease-free survival (DFS) was 90.2 %. The median follow-up duration was 52.3 months. Twenty-one patients (8.5 %) experienced recurrence, with 8 local-regional and 13 distant recurrences. Compared with patients without recurrence, patients with recurrence had more advanced cancer stage, bigger tumor size, higher percentage of lymph node metastasis, and higher NLR. Multivariate analysis showed that recurrence of TNBC is 3.6 times higher in patients with lymph node metastasis than those without, and it is also 8.9 times higher in patients with baseline NLR >3.4 than ≤3.4.
Conclusion
Lymph node metastasis and elevated NLR are significant predictors of poor DFS in TNBC patients undergoing upfront surgery. Patients with NLR higher than 3.4 have a worse prognosis.
{"title":"Prognostic factors for early-stage triple-negative breast cancer with a focus on neutrophil-to-lymphocyte ratio: A single-center retrospective study","authors":"Yu-Kwang Lee , Chen-Yang Hsu , Ming-Yang Wang , Wen-Hung Kuo , Huang-Chun Lien , Yi-Hsuan Lee , Chiao Lo , Chiun-Sheng Huang","doi":"10.1016/j.tjog.2025.04.019","DOIUrl":"10.1016/j.tjog.2025.04.019","url":null,"abstract":"<div><h3>Objective</h3><div>Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Prognostic factors for TNBC are still inconclusive due to its heterogeneity. Neutrophil-to-lymphocyte ratio (NLR) has been reported as a valuable and cost effective prognostic tool for breast cancer patients. In this study, we aim to identify the prognostic factors for TNBC with a focus on NLR.</div></div><div><h3>Materials and methods</h3><div>We retrospectively analyzed stage I-III TNBC patients receiving upfront operation at National Taiwan University Hospital (NTUH) between January 2015 and December 2021. Age, tumor size, lymph node metastasis, cancer stage, histologic grade, lymphovascular invasion, perineural invasion, Ki67 levels, and neutrophil-to-lymphocyte ratio (NLR) were analyzed as prognostic factors. We used 3.4 as the cutoff point for NLR.</div></div><div><h3>Results</h3><div>We identified 248 stage I-III patients, the overall 5-year disease-free survival (DFS) was 90.2 %. The median follow-up duration was 52.3 months. Twenty-one patients (8.5 %) experienced recurrence, with 8 local-regional and 13 distant recurrences. Compared with patients without recurrence, patients with recurrence had more advanced cancer stage, bigger tumor size, higher percentage of lymph node metastasis, and higher NLR. Multivariate analysis showed that recurrence of TNBC is 3.6 times higher in patients with lymph node metastasis than those without, and it is also 8.9 times higher in patients with baseline NLR >3.4 than ≤3.4.</div></div><div><h3>Conclusion</h3><div>Lymph node metastasis and elevated NLR are significant predictors of poor DFS in TNBC patients undergoing upfront surgery. Patients with NLR higher than 3.4 have a worse prognosis.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 1030-1036"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Being a new vaccine platform, continuous monitoring of the mRNA COVID-19 vaccines in pregnant women is of critical importance. This systematic review and meta-analysis evaluate the maternal and neonatal outcomes associated with mRNA COVID-19 vaccination during pregnancy. We conducted a systematic search of PubMed, Embase, Cochrane Library, and clinical trial registries for studies published between December 2020 and July 2024. Studies were included if they assessed obstetric and neonatal outcomes following mRNA COVID-19 vaccination in pregnant women. Data were extracted and analyzed using a random-effects model to calculate pooled odds ratios (ORs) and 95 % confidence intervals (CIs). Fifteen studies met the inclusion criteria, encompassing 42,944 vaccinated and 183,733 unvaccinated pregnant women. mRNA vaccination was associated with a significant reduction in preterm delivery (OR 0.743, 95 % CI 0.607–0.911), fetal distress (OR 0.699, 95 % CI 0.546–0.893), neonatal congenital abnormalities (OR 0.712, 95 % CI 0.570–0.889), and NICU admissions (OR 0.718, 95 % CI 0.617–0.836). However, a slight increase in gestational diabetes risk was observed (OR 1.107, 95 % CI 1.054–1.162). mRNA COVID-19 vaccines are safe during pregnancy and associated with reduced risks of adverse obstetric and neonatal outcomes. An observed marginal increase in gestational diabetes risk underscores the need for continuous monitoring. These findings support the inclusion of pregnant women in vaccination campaigns and inform public health policies and clinical practices to improve maternal and neonatal health outcomes.
作为一个新的疫苗平台，持续监测孕妇的mRNA COVID-19疫苗至关重要。本系统综述和荟萃分析评估了与妊娠期mRNA - COVID-19疫苗接种相关的孕产妇和新生儿结局。我们对PubMed、Embase、Cochrane图书馆和临床试验注册库进行了系统检索，检索了2020年12月至2024年7月间发表的研究。如果研究评估孕妇接种mRNA COVID-19疫苗后的产科和新生儿结局，则纳入研究。采用随机效应模型提取和分析数据，计算合并优势比（ORs）和95%置信区间（ci）。15项研究符合纳入标准，包括42944名接种疫苗的孕妇和183733名未接种疫苗的孕妇。mRNA疫苗接种与早产（OR 0.743, 95% CI 0.607-0.911）、胎儿窘迫（OR 0.699, 95% CI 0.546-0.893）、新生儿先天性异常（OR 0.712, 95% CI 0.570-0.889）和新生儿重症监护病房入院（OR 0.718, 95% CI 0.617-0.836）的显著降低相关。然而，观察到妊娠糖尿病风险略有增加（OR 1.107, 95% CI 1.054-1.162）。mRNA - COVID-19疫苗在妊娠期间是安全的，并可降低不良产科和新生儿结局的风险。观察到的妊娠期糖尿病风险的边际增加强调了持续监测的必要性。这些发现支持将孕妇纳入疫苗接种运动，并为公共卫生政策和临床实践提供信息，以改善孕产妇和新生儿的健康结果。
{"title":"Updating the impact of mRNA COVID-19 vaccine exposure during pregnancy on obstetric and neonatal outcomes","authors":"Frank Adusei-Mensah , Olubunmi Olubamwo , Sunday Olaleye , Laboni Akter , Oluwafemi Samson Balogun , Rethabile Joyce Moshoeshoe , Luqman Awoniyi , Adedayo Olawuni , Jussi Kauhanen","doi":"10.1016/j.tjog.2025.07.022","DOIUrl":"10.1016/j.tjog.2025.07.022","url":null,"abstract":"<div><div>Being a new vaccine platform, continuous monitoring of the mRNA COVID-19 vaccines in pregnant women is of critical importance. This systematic review and meta-analysis evaluate the maternal and neonatal outcomes associated with mRNA COVID-19 vaccination during pregnancy. We conducted a systematic search of PubMed, Embase, Cochrane Library, and clinical trial registries for studies published between December 2020 and July 2024. Studies were included if they assessed obstetric and neonatal outcomes following mRNA COVID-19 vaccination in pregnant women. Data were extracted and analyzed using a random-effects model to calculate pooled odds ratios (ORs) and 95 % confidence intervals (CIs). Fifteen studies met the inclusion criteria, encompassing 42,944 vaccinated and 183,733 unvaccinated pregnant women. mRNA vaccination was associated with a significant reduction in preterm delivery (OR 0.743, 95 % CI 0.607–0.911), fetal distress (OR 0.699, 95 % CI 0.546–0.893), neonatal congenital abnormalities (OR 0.712, 95 % CI 0.570–0.889), and NICU admissions (OR 0.718, 95 % CI 0.617–0.836). However, a slight increase in gestational diabetes risk was observed (OR 1.107, 95 % CI 1.054–1.162). mRNA COVID-19 vaccines are safe during pregnancy and associated with reduced risks of adverse obstetric and neonatal outcomes. An observed marginal increase in gestational diabetes risk underscores the need for continuous monitoring. These findings support the inclusion of pregnant women in vaccination campaigns and inform public health policies and clinical practices to improve maternal and neonatal health outcomes.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Pages 957-970"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145475767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tjog.2025.09.016
Chih-Ping Chen
{"title":"Follow-up of a 2-year-and-6-month-old boy with a favorable outcome and a prenatal history of low-level mosaic trisomy 13 at amniocentesis","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.09.016","DOIUrl":"10.1016/j.tjog.2025.09.016","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Page 1122"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tjog.2025.07.028
Jiaxuan Tan, Hongmei Shen
{"title":"Common on “Prenatal diagnosis of a de novo 16p11.2 microduplication of 16p11.2 BP4-5 copy number variants in a fetus with apparently normal phenotype”","authors":"Jiaxuan Tan, Hongmei Shen","doi":"10.1016/j.tjog.2025.07.028","DOIUrl":"10.1016/j.tjog.2025.07.028","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 6","pages":"Page 1131"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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