Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.04.024
Mika Mizuno, Mai Nakazono, Mika Fukuda, Shintaro Yanazume, Shinichi Togami, Hiroaki Kobayashi
Objective
Niraparib (NIRA) is a poly(ADP-ribose) polymerase inhibitor used as maintenance therapy for ovarian carcinomas. Thrombocytopenia is a common adverse event associated with NIRA. This study aimed to evaluate the frequency of NIRA-induced thrombocytopenia and the associated risk factors in clinical practice.
Materials and methods
Data from 30 patients who received NIRA as a first-line or recurrent treatment at our institution were retrospectively analyzed to assess reductions in platelet count (PLT).
Results
The median participant age was 59 (range: 39–75) years, and the median weight was 50 (range: 36–80) kg. NIRA was initiated at a median of 4 (range: 3–8) weeks after the last chemotherapy dose. The prevalence of grade ≥3 thrombocytopenia was 23.3 %, dose interruptions occurred in 53.3 % and dose reductions occurred in 40 %. The median follow-up time was 20 (range: 2–166) months after resumption. Due to thrombocytopenia, one patient discontinued treatment 2 weeks after administration (nadir PLT: 1 × 109/L), and 2 others discontinued treatment after resumption. For the non-interruption and interruption groups, the median nadir PLTs were 194 (91–318) and 57 (1–89) × 109/L (p < 0.001), respectively, the median baseline PLTs were 215 vs. 120 × 109/L (p < 0.001), respectively, and the nadir PLTs during prior chemotherapy were 175 vs. 73 × 109/L (p = 0.007), respectively. Lower baseline PLTs were significantly associated with an increased risk of thrombocytopenia (OR 0.793, 95 % CI 0.654–0.964; p = 0.019).
Conclusions
Our real-world data reaffirmed that thrombocytopenia is a significant adverse event that affects the continuation of NIRA and requires careful monitoring. Adjusting the start time to ensure an adequate baseline PLT may help mitigate this risk, but larger-scale studies are needed to validate these findings.
{"title":"Impact of niraparib on reducing the platelet count in patients with ovarian cancer","authors":"Mika Mizuno, Mai Nakazono, Mika Fukuda, Shintaro Yanazume, Shinichi Togami, Hiroaki Kobayashi","doi":"10.1016/j.tjog.2025.04.024","DOIUrl":"10.1016/j.tjog.2025.04.024","url":null,"abstract":"<div><h3>Objective</h3><div>Niraparib (NIRA) is a poly(ADP-ribose) polymerase inhibitor used as maintenance therapy for ovarian carcinomas. Thrombocytopenia is a common adverse event associated with NIRA. This study aimed to evaluate the frequency of NIRA-induced thrombocytopenia and the associated risk factors in clinical practice.</div></div><div><h3>Materials and methods</h3><div>Data from 30 patients who received NIRA as a first-line or recurrent treatment at our institution were retrospectively analyzed to assess reductions in platelet count (PLT).</div></div><div><h3>Results</h3><div>The median participant age was 59 (range: 39–75) years, and the median weight was 50 (range: 36–80) kg. NIRA was initiated at a median of 4 (range: 3–8) weeks after the last chemotherapy dose. The prevalence of grade ≥3 thrombocytopenia was 23.3 %, dose interruptions occurred in 53.3 % and dose reductions occurred in 40 %. The median follow-up time was 20 (range: 2–166) months after resumption. Due to thrombocytopenia, one patient discontinued treatment 2 weeks after administration (nadir PLT: 1 × 10<sup>9</sup>/L), and 2 others discontinued treatment after resumption. For the non-interruption and interruption groups, the median nadir PLTs were 194 (91–318) and 57 (1–89) × 10<sup>9</sup>/L (p < 0.001), respectively, the median baseline PLTs were 215 vs. 120 × 10<sup>9</sup>/L (p < 0.001), respectively, and the nadir PLTs during prior chemotherapy were 175 vs. 73 × 10<sup>9</sup>/L (p = 0.007), respectively. Lower baseline PLTs were significantly associated with an increased risk of thrombocytopenia (OR 0.793, 95 % CI 0.654–0.964; p = 0.019).</div></div><div><h3>Conclusions</h3><div>Our real-world data reaffirmed that thrombocytopenia is a significant adverse event that affects the continuation of NIRA and requires careful monitoring. Adjusting the start time to ensure an adequate baseline PLT may help mitigate this risk, but larger-scale studies are needed to validate these findings.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 75-80"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.07.029
I-Ning Cheng , Tsung-Hsuan Lai
Objective
To present a rare case of uterine rupture after vaginal delivery under epidural anesthesia in a nulliparous woman without prior uterine surgery.
Case report
A 38-year-old primiparous woman with a history of infertility conceived through in vitro fertilization. At 39 weeks of gestation, she was admitted due to spontaneous premature rupture of membranes. Oxytocin was administered for labor augmentation, and fundal pressure was applied for maternal exhaustion, leading to the delivery of a healthy infant. Secondary laceration of perineum was found but no cervical laceration was detected just after vaginal delivery. Primary repair was performed layers by layers smoothly. Shortly after delivery, the patient developed hypotension, tachycardia, nausea, and poor uterine tone, but without abdominal pain, likely due to epidural anesthesia masking symptoms. Abdominal ultrasound revealed intrauterine clots and some fluid in the cul-de-sac, suggesting uterine rupture. An emergent laparotomy identified a 10 cm posterior uterine laceration, which was successfully repaired.
Conclusion
This case highlights the importance of promptly recognizing atypical or subtle signs of uterine rupture particularly when classical symptoms are masked by epidural anesthesia. Clinicians should maintain a highly suspicion and closely monitor for alternative indicators, such as hemodynamic instability or abnormal fetal heart rate patterns. In addition, fundal pressure should be applied with caution, especially in patients with risk factors for uterine rupture such as myomectomy, to minimize the risk of adverse maternal outcomes.
{"title":"Risk factors and diagnostic challenges in a nullipara with spontaneous uterine rupture during vaginal delivery","authors":"I-Ning Cheng , Tsung-Hsuan Lai","doi":"10.1016/j.tjog.2025.07.029","DOIUrl":"10.1016/j.tjog.2025.07.029","url":null,"abstract":"<div><h3>Objective</h3><div>To present a rare case of uterine rupture after vaginal delivery under epidural anesthesia in a nulliparous woman without prior uterine surgery.</div></div><div><h3>Case report</h3><div>A 38-year-old primiparous woman with a history of infertility conceived through in vitro fertilization. At 39 weeks of gestation, she was admitted due to spontaneous premature rupture of membranes. Oxytocin was administered for labor augmentation, and fundal pressure was applied for maternal exhaustion, leading to the delivery of a healthy infant. Secondary laceration of perineum was found but no cervical laceration was detected just after vaginal delivery. Primary repair was performed layers by layers smoothly. Shortly after delivery, the patient developed hypotension, tachycardia, nausea, and poor uterine tone, but without abdominal pain, likely due to epidural anesthesia masking symptoms. Abdominal ultrasound revealed intrauterine clots and some fluid in the cul-de-sac, suggesting uterine rupture. An emergent laparotomy identified a 10 cm posterior uterine laceration, which was successfully repaired.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of promptly recognizing atypical or subtle signs of uterine rupture particularly when classical symptoms are masked by epidural anesthesia. Clinicians should maintain a highly suspicion and closely monitor for alternative indicators, such as hemodynamic instability or abnormal fetal heart rate patterns. In addition, fundal pressure should be applied with caution, especially in patients with risk factors for uterine rupture such as myomectomy, to minimize the risk of adverse maternal outcomes.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 119-122"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.06.005
Jenn-Jhy Tseng , Shen-Ling Jan , Chia-Jung Hsieh , Li-Ling Lin , Hsien-Wen Peng
<div><h3>Objective</h3><div>Congenital heart diseases (CHDs), the most common congenital anomalies, significantly impact pediatric morbidity and mortality. This 15-year retrospective study investigates prenatal features and postnatal outcomes in CHD cases, focusing on factors influencing surgical intervention, mortality, and long-term care.</div></div><div><h3>Materials and methods</h3><div>We retrospectively reviewed 170 perinatally diagnosed CHD cases at Taichung Veterans General Hospital between January 2008 and October 2023. Diagnosis was primarily based on two-dimensional grayscale and Doppler echocardiography, with speckle tracking echocardiography (STE) employed in several cases. Among these, 119 ongoing pregnancies continued to delivery, 32 ended in termination of pregnancy (TOP) or intrauterine fetal demise (IUFD), and 19 were lost to follow-up. CHDs were categorized using two classification systems based on anatomical, physiological, and locational criteria. Maternal and fetal characteristics and echocardiographic findings were analyzed.</div></div><div><h3>Results</h3><div>Prenatal diagnosis was achieved in 93.5 % of cases, with a median gestational age of 22 weeks at diagnosis. Genetic abnormalities were detected in 3.4 % of cases for karyotypes and 9.3 % for gene dosage changes. CHD subtype distributions varied significantly among outcome groups. In classification-1, left-to-right shunts and arrhythmias predominated in the delivery group, cyanotic CHDs were most common in the TOP/IUFD group, and obstructive lesions/miscellaneous conditions were more frequent in the lost to follow-up group (<em>P</em> = 0.012). In classification-2, right- and left-sided disorders were most frequent in the delivery group, while mixed or unclassified disorders dominated the TOP/IUFD group (<em>P</em> = 0.003). Isolated CHDs accounted for 71.2 % of cases but were significantly less frequent in the TOP/IUFD group (<em>P</em> = 0.001). A higher number of coexistent intracardiac anomalies increased the risk of TOP/IUFD (<em>P</em> < 0.001). Significant group differences were also noted for isolated ventricular septal defect (<em>P</em> = 0.009) and right aortic arch (<em>P</em> = 0.003). Among the 119 deliveries, 24.4 % required early postnatal interventions. Predictive factors included cyanotic CHDs, obstructive lesions, and arrhythmias (<em>P</em> < 0.001). Neonatal mortality was strongly associated with a 5-min Apgar score <7 (adjusted odds ratio [aOR] 6.63, <em>P</em> = 0.037). Coexistent intracardiac anomalies increased the risk of hospital readmission (aOR 1.71, <em>P</em> = 0.034) and post-neonatal surgery (adjusted hazard ratio [aHR] 1.63, <em>P</em> < 0.001). Both STE and conventional echocardiography provided important insights into myocardial function and hemodynamics in severe cases.</div></div><div><h3>Conclusion</h3><div>CHD type, complexity, and coexisting conditions, along with key prenatal and postnatal factors, significantly in
{"title":"Prenatal and postnatal determinants of clinical outcomes in congenital heart diseases: A 15-year retrospective cohort study","authors":"Jenn-Jhy Tseng , Shen-Ling Jan , Chia-Jung Hsieh , Li-Ling Lin , Hsien-Wen Peng","doi":"10.1016/j.tjog.2025.06.005","DOIUrl":"10.1016/j.tjog.2025.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>Congenital heart diseases (CHDs), the most common congenital anomalies, significantly impact pediatric morbidity and mortality. This 15-year retrospective study investigates prenatal features and postnatal outcomes in CHD cases, focusing on factors influencing surgical intervention, mortality, and long-term care.</div></div><div><h3>Materials and methods</h3><div>We retrospectively reviewed 170 perinatally diagnosed CHD cases at Taichung Veterans General Hospital between January 2008 and October 2023. Diagnosis was primarily based on two-dimensional grayscale and Doppler echocardiography, with speckle tracking echocardiography (STE) employed in several cases. Among these, 119 ongoing pregnancies continued to delivery, 32 ended in termination of pregnancy (TOP) or intrauterine fetal demise (IUFD), and 19 were lost to follow-up. CHDs were categorized using two classification systems based on anatomical, physiological, and locational criteria. Maternal and fetal characteristics and echocardiographic findings were analyzed.</div></div><div><h3>Results</h3><div>Prenatal diagnosis was achieved in 93.5 % of cases, with a median gestational age of 22 weeks at diagnosis. Genetic abnormalities were detected in 3.4 % of cases for karyotypes and 9.3 % for gene dosage changes. CHD subtype distributions varied significantly among outcome groups. In classification-1, left-to-right shunts and arrhythmias predominated in the delivery group, cyanotic CHDs were most common in the TOP/IUFD group, and obstructive lesions/miscellaneous conditions were more frequent in the lost to follow-up group (<em>P</em> = 0.012). In classification-2, right- and left-sided disorders were most frequent in the delivery group, while mixed or unclassified disorders dominated the TOP/IUFD group (<em>P</em> = 0.003). Isolated CHDs accounted for 71.2 % of cases but were significantly less frequent in the TOP/IUFD group (<em>P</em> = 0.001). A higher number of coexistent intracardiac anomalies increased the risk of TOP/IUFD (<em>P</em> < 0.001). Significant group differences were also noted for isolated ventricular septal defect (<em>P</em> = 0.009) and right aortic arch (<em>P</em> = 0.003). Among the 119 deliveries, 24.4 % required early postnatal interventions. Predictive factors included cyanotic CHDs, obstructive lesions, and arrhythmias (<em>P</em> < 0.001). Neonatal mortality was strongly associated with a 5-min Apgar score <7 (adjusted odds ratio [aOR] 6.63, <em>P</em> = 0.037). Coexistent intracardiac anomalies increased the risk of hospital readmission (aOR 1.71, <em>P</em> = 0.034) and post-neonatal surgery (adjusted hazard ratio [aHR] 1.63, <em>P</em> < 0.001). Both STE and conventional echocardiography provided important insights into myocardial function and hemodynamics in severe cases.</div></div><div><h3>Conclusion</h3><div>CHD type, complexity, and coexisting conditions, along with key prenatal and postnatal factors, significantly in","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 44-54"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.12.002
Szu-Ting Yang , Che-Wei Chang , Peng-Hui Wang
Objective
The prognostic significance of glandular involvement in high-grade squamous intraepithelial lesions (HSIL) following cervical conization remains unclear. This research aimed to evaluate the clinical impact of glandular involvement on surgical outcomes.
Materials and methods
Between December 2019 and December 2020, 119 patients who underwent cervical conization were retrospectively observed. Patient characteristics, such as human papillomavirus (HPV) status, cytology results, glandular involvement, conization specimen depth and volume, margin status, and recurrence were collected and analyzed.
Results
Glandular involvement was significantly associated with positive endocervical margins (22.0 % vs. 6.5 %, p = 0.017), higher prevalence of preceding HSIL or CIN (cervical intraepithelial neoplasm)2/CIN3 cytology (60.4 % vs. 42.0 %), and increased HPV16 infection among high-risk HPV positive patients (69.2 % vs. 34.8 %, p = 0.050). No significant differences were observed in recurrence rates among patients with HSIL with or without glandular involvement. Multivariable analysis identified that margin status is the only independent predictor of recurrence (positive margin: OR [odds ratio] 26.85, 95 % CI [confidence interval] 2.59–277.86, p = 0.006 or uncertain margins: OR 29.90, 95 % CI 1.09–818.17, p = 0.044).
Conclusion
While glandular involvement in HSIL is associated with positive endocervical margins, abnormal preceding cytology, and higher risk of HPV16 infection, it does not independently predict recurrence following conization. Instead, positive surgical margins are the primary factor of recurrence, highlighting the value of achieving complete excision to optimize patient outcomes.
目的尚不清楚宫颈锥切术后高级别鳞状上皮内病变（HSIL）是否累及腺体对预后的影响。本研究旨在评估腺体受累对手术结果的临床影响。材料与方法对2019年12月至2020年12月间行宫颈锥切术的119例患者进行回顾性观察。收集并分析患者特征，如人乳头瘤病毒（HPV）状态、细胞学结果、腺体受损伤、锥形标本深度和体积、边缘状态和复发。结果腺体受损伤与宫颈内切缘阳性（22.0%比6.5%,p = 0.017）、宫颈上皮内肿瘤（HSIL）或宫颈上皮内肿瘤（CIN）2/CIN3细胞学检查（60.4%比42.0%）、高危HPV阳性患者HPV16感染增加（69.2%比34.8%,p = 0.050）显著相关。有或无腺体受累的HSIL患者的复发率无显著差异。多变量分析表明，切缘状态是复发的唯一独立预测因子（阳性切缘：OR[比值比]26.85,95% CI[置信区间]2.59-277.86,p = 0.006；不确定切缘：OR 29.90, 95% CI 1.09-818.17, p = 0.044）。结论虽然HSIL的腺体累及与宫颈内切缘阳性、前期细胞学异常和HPV16感染的高风险相关，但它不能独立预测锥形切除术后的复发。相反，阳性手术切缘是复发的主要因素，强调了实现完全切除以优化患者预后的价值。
{"title":"Clinical impact of glandular involvement in high-grade squamous intraepithelial lesions of the cervix","authors":"Szu-Ting Yang , Che-Wei Chang , Peng-Hui Wang","doi":"10.1016/j.tjog.2025.12.002","DOIUrl":"10.1016/j.tjog.2025.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>The prognostic significance of glandular involvement in high-grade squamous intraepithelial lesions (HSIL) following cervical conization remains unclear. This research aimed to evaluate the clinical impact of glandular involvement on surgical outcomes.</div></div><div><h3>Materials and methods</h3><div>Between December 2019 and December 2020, 119 patients who underwent cervical conization were retrospectively observed. Patient characteristics, such as human papillomavirus (HPV) status, cytology results, glandular involvement, conization specimen depth and volume, margin status, and recurrence were collected and analyzed.</div></div><div><h3>Results</h3><div>Glandular involvement was significantly associated with positive endocervical margins (22.0 % <em>vs</em>. 6.5 %, <em>p</em> = 0.017), higher prevalence of preceding HSIL or CIN (cervical intraepithelial neoplasm)2/CIN3 cytology (60.4 % <em>vs</em>. 42.0 %), and increased HPV16 infection among high-risk HPV positive patients (69.2 % <em>vs</em>. 34.8 %, <em>p</em> = 0.050). No significant differences were observed in recurrence rates among patients with HSIL with or without glandular involvement. Multivariable analysis identified that margin status is the only independent predictor of recurrence (positive margin: OR [odds ratio] 26.85, 95 % CI [confidence interval] 2.59–277.86, <em>p</em> = 0.006 or uncertain margins: OR 29.90, 95 % CI 1.09–818.17, <em>p</em> = 0.044).</div></div><div><h3>Conclusion</h3><div>While glandular involvement in HSIL is associated with positive endocervical margins, abnormal preceding cytology, and higher risk of HPV16 infection, it does not independently predict recurrence following conization. Instead, positive surgical margins are the primary factor of recurrence, highlighting the value of achieving complete excision to optimize patient outcomes.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 64-69"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral venous thrombosis is a rare disease with a high mortality rate. Pregnancy can increase the risk of intracranial venous sinus thrombosis formation, and this condition in turn elevates the maternal mortality rate. Therefore, early diagnosis and appropriate treatment of intracranial venous sinus thrombosis during pregnancy are crucial for the prognosis of pregnant women.
Case Report
We present a case of 30-year-old woman who had a spontaneous conception, thrombophilia occurring in the early stages of pregnancy, which was further aggravated by cerebral venous thrombosis. However, with appropriate medical intervention, a successful full-term delivery occurred.
Conclusion
The management of cerebral venous thrombosis during pregnancy is of great importance. When the patient's condition permits, conservative treatment can be adopted, leading to a favorable prognosis for both the mother and the fetus.
{"title":"Conservative management of early-onset cerebral venous thrombosis in pregnancy resulting in full-term delivery: A case report","authors":"Xiaoqian Pan , Xiaoli Zhang , Rui Qin , Heyun Ruan","doi":"10.1016/j.tjog.2025.09.022","DOIUrl":"10.1016/j.tjog.2025.09.022","url":null,"abstract":"<div><h3>Objective</h3><div>Cerebral venous thrombosis is a rare disease with a high mortality rate. Pregnancy can increase the risk of intracranial venous sinus thrombosis formation, and this condition in turn elevates the maternal mortality rate. Therefore, early diagnosis and appropriate treatment of intracranial venous sinus thrombosis during pregnancy are crucial for the prognosis of pregnant women.</div></div><div><h3>Case Report</h3><div>We present a case of 30-year-old woman who had a spontaneous conception, thrombophilia occurring in the early stages of pregnancy, which was further aggravated by cerebral venous thrombosis. However, with appropriate medical intervention, a successful full-term delivery occurred.</div></div><div><h3>Conclusion</h3><div>The management of cerebral venous thrombosis during pregnancy is of great importance. When the patient's condition permits, conservative treatment can be adopted, leading to a favorable prognosis for both the mother and the fetus.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 99-102"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.007
Chih-Ping Chen
{"title":"Prenatal diagnosis of a 2.61-Mb de novo 22q11.21 microduplication encompassing TBX1 in a pregnancy associated with no apparently phenotypic abnormality in the fetus","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.007","DOIUrl":"10.1016/j.tjog.2025.11.007","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 134-135"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.08.004
Wenhui Wang , Zihan Yan , Yuanyuan Chen , Kang Ren , Xiaorong Hou , Ke Hu , Fuquan Zhang
Objective
Pathological characteristics and MMR status can be determined from microscopic indicators and immunohistochemical (IHC) staining of surgical specimens, and these approaches are more cost-effective and convenient than genome profiling tests. We aimed to evaluate the impact of MMR deficiency on survival outcomes and build a new prognostic model for early-stage endometrial carcinoma (EC) patients.
Materials and methods
Patients with stage I to II EC who underwent hysterectomy followed by adjuvant radiotherapy from Oct. 2017 to Dec. 2020 at our institution were retrospectively reviewed. Tumor MMR status was routinely tested by IHC. According to MMR status, they were classified into intact MMR (MMRp) group and defective MMR (MMRd) group.
Results
Patients were classified into MMRp group (n = 207) and MMRd group (n = 69). Compared with those in the MMRp group, patients in the MMRd group were more likely to have high-grade disease, LVSI, and high-intermediate risk (HIR)-to-high risk (HR) classifications. The 3-year CSS, DFS, and DMFS rates were significantly lower in the MMRd group. When patients were stratified by risk group, DFS and DMFS were significantly worse among MMRd patients in the HIR-to-HR group. Regarding failure patterns, MMRd patients were more likely to experience distant failure. Among 276 patients, multivariate Cox analysis revealed that ER or PR status, myometrial invasion (MI), MMR status, and LVSI were independent prognostic factors for DFS, whereas ER or PR status, MMR status, and MI were significant predictors of DMFS. A prediction model combining the MMR status and the significant prognostic predictors mentioned above in the multivariate analysis was built through nomogram models.
Conclusion
Among early-stage EC patients, MMRd group had poorer survivals. Combination of MMR status and other clinicopathological factors could establish a new prognostic model. Prospective studies with full molecular sequencing to determine the prognostic significance of MMR status are needed.
{"title":"Impact of mismatch repair genes deficiency on survival outcomes and establishment of a novel prognostic prediction model for stage I-II endometrial carcinoma","authors":"Wenhui Wang , Zihan Yan , Yuanyuan Chen , Kang Ren , Xiaorong Hou , Ke Hu , Fuquan Zhang","doi":"10.1016/j.tjog.2025.08.004","DOIUrl":"10.1016/j.tjog.2025.08.004","url":null,"abstract":"<div><h3>Objective</h3><div>Pathological characteristics and MMR status can be determined from microscopic indicators and immunohistochemical (IHC) staining of surgical specimens, and these approaches are more cost-effective and convenient than genome profiling tests. We aimed to evaluate the impact of MMR deficiency on survival outcomes and build a new prognostic model for early-stage endometrial carcinoma (EC) patients.</div></div><div><h3>Materials and methods</h3><div>Patients with stage I to II EC who underwent hysterectomy followed by adjuvant radiotherapy from Oct. 2017 to Dec. 2020 at our institution were retrospectively reviewed. Tumor MMR status was routinely tested by IHC. According to MMR status, they were classified into intact MMR (MMRp) group and defective MMR (MMRd) group.</div></div><div><h3>Results</h3><div>Patients were classified into MMRp group (n = 207) and MMRd group (n = 69). Compared with those in the MMRp group, patients in the MMRd group were more likely to have high-grade disease, LVSI, and high-intermediate risk (HIR)-to-high risk (HR) classifications. The 3-year CSS, DFS, and DMFS rates were significantly lower in the MMRd group. When patients were stratified by risk group, DFS and DMFS were significantly worse among MMRd patients in the HIR-to-HR group. Regarding failure patterns, MMRd patients were more likely to experience distant failure. Among 276 patients, multivariate Cox analysis revealed that ER or PR status, myometrial invasion (MI), MMR status, and LVSI were independent prognostic factors for DFS, whereas ER or PR status, MMR status, and MI were significant predictors of DMFS. A prediction model combining the MMR status and the significant prognostic predictors mentioned above in the multivariate analysis was built through nomogram models.</div></div><div><h3>Conclusion</h3><div>Among early-stage EC patients, MMRd group had poorer survivals. Combination of MMR status and other clinicopathological factors could establish a new prognostic model. Prospective studies with full molecular sequencing to determine the prognostic significance of MMR status are needed.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 81-88"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.012
Chih-Ping Chen
{"title":"High-level mosaicism for 45,X in 45,X/46,XX at amniocentesis associated with postnatal progressive decrease of the 45,X cell line and a favorable fetal outcome in a twin pregnancy","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.012","DOIUrl":"10.1016/j.tjog.2025.11.012","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 149-150"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.018
Chih-Ping Chen
{"title":"Mosaic 17q24.3q25.3 duplication at amniocentesis in a pregnancy associated with a favorable fetal outcome in a male fetus","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.018","DOIUrl":"10.1016/j.tjog.2025.11.018","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 164-166"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.009
Chih-Ping Chen , Ming Chen , Gwo-Chin Ma , Shun-Ping Chang , Wayseen Wang
{"title":"Molecular cytogenetic characterization of a de novo small supernumerary marker chromosome detected by amniocentesis and derived from the acrocentric chromosome 14/22","authors":"Chih-Ping Chen , Ming Chen , Gwo-Chin Ma , Shun-Ping Chang , Wayseen Wang","doi":"10.1016/j.tjog.2025.11.009","DOIUrl":"10.1016/j.tjog.2025.11.009","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 140-142"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号