Taiwanese Journal of Obstetrics & Gynecology最新文献

{"title":"Menopause part I: Vasomotor symptoms (I)","authors":"Peng-Hui Wang ,&nbsp;Szu-Ting Yang ,&nbsp;Wen-Hsun Chang ,&nbsp;Wen-Ling Lee","doi":"10.1016/j.tjog.2025.01.001","DOIUrl":"10.1016/j.tjog.2025.01.001","url":null,"abstract":"<div><div>Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production of estrogen) without another pathological or physiological cause becomes one of the most health issues in the world. Vasomotor symptoms (VMS) is a hallmark of menopause, occurring in up to 80 % of women experiencing and persisting for over seven years with significant negative impacts on physical, psychological, social, and overall wellbeing. Conventionally, menopause hormone therapy (MHT) is considered the most effective therapeutic opinion for many years based on the fact as “deficiency of estrogen”; however, the ratio of benefits and risk is highly debated and always in concern. Therefore, the non-MHT agent focusing the underlying pathophysiology of VMS, such as hypothalamus-pituitary-ovary axis is becoming attractive. Based on this concept, the hypothalamus neural construct containing Kisspeptin (Kp) neurons in median pre-optic area (POA) or Kp-neurokinin B (NKB)-dynorphin (DYN) neurons (KNDy neurons) in the infundibular nucleus is identified as the thermoregulatory circultry to involve the pathophysiology of normal reproduction and menopause-associated VMS. The neurokinin 3 receptor (NK3R) antagonists applied to VMS are an enthusiasm with a big success. Fezolinetant is one of the best breakthroughs. Recent three randomized clinical trials (RCTs), including SKYLIGHT 1,2, and 4 confirmed the safety and efficacy for treating moderate-to-severe VMS women. By contrast, another MONGLIGHT RCTs for East Asia population seemed to controversial therapeutic effect for VMS treatment, but there is no doubt that safety issue is also satisfied, contributing to the need of more RCTs to validate its efficacy in diverse population. The current review will summary the recent advance of this new landscape in the management of women with moderate-to-severe VMS and particularly focus on the fezolinetant product.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Pages 230-238"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of Platelet-Rich Plasma (PRP) on the sperm parameters","authors":"Sedighe Hosseini ,&nbsp;Mahsa Kazemi ,&nbsp;Saghar Salehpour ,&nbsp;Nasrin Saharkhiz ,&nbsp;Leila Majdi","doi":"10.1016/j.tjog.2024.12.010","DOIUrl":"10.1016/j.tjog.2024.12.010","url":null,"abstract":"<div><h3>Objective</h3><div>Platelet-rich plasma (PRP) has been widely used to treat women with infertility but is rarely used in men with similar conditions. Several studies have shown that PRP contains a large spectrum of growth factors that may benefit sperm, but the application of PRP in sperm processing techniques has not been examined completely yet. This study aimed to investigate the effect of adding PRP supplementation to human semen in the incubation and swim-up processes and evaluate the sperm parameters after PRP addition.</div></div><div><h3>Material and method</h3><div>The current experimental study has included 80 semen samples. The semen samples were collected from 40 men with asthenoteratozoospermia and 40 normozoospermic men. The study was conducted at the Infertility Center of Taleghani Hospital from October 2023 to April 2024, and the role of PRP on sperm parameters was tested based on WHO guidelines. Each sample was divided into two equal parts. The first one, as a control, received no platelet-rich plasma, and the second sample portion was added directly to 2 % concentrations of platelet-rich plasma. The incubation and swim-up processes were performed in two groups, and sperm parameters were compared between samples incubated with PRP and samples without PRP treatment.</div></div><div><h3>Results</h3><div>After incubation, the results of normal samples showed a significant rise in sperm total and progressive motility. However, the increasing effect on sperm non-progressive motility and viability was not substantial. The asthenoteratozoospermic samples showed a significant rise in sperm total, progressive, and non-progressive motility, but the increasing effect on sperm viability was not significant. After swim-up, the results of normal samples showed a significant rise in concentration and sperm total and progressive motility but the rise in sperm non-progressive motility and morphology was not significant. The results in samples with the asthenoteratozoospermic group showed a significant rise in concentration, total motility, progressive motility, and non-progressive motility but the rise in sperm morphology was not significant.</div></div><div><h3>Conclusion</h3><div>These results show that PRP has effectively improved human sperm quality. So we can suggest that incubation and swim-up of semen samples with PRP may be considered as a new treatment option for men with infertility undergoing assisted reproductive technology (ART).</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Pages 313-318"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Would internal iliac artery occlusion cause gestational hypertension in the following pregnancy? A population-based study from 2008 to 2017","authors":"Yu-Lun Ku ,&nbsp;Ying-Yi Chen ,&nbsp;Yao-Hsu Yang ,&nbsp;Chuan-Pin Lee ,&nbsp;Ko-Jung Chen ,&nbsp;Yu-Che Ou","doi":"10.1016/j.tjog.2024.12.009","DOIUrl":"10.1016/j.tjog.2024.12.009","url":null,"abstract":"<div><h3>Objective</h3><div>In animal models, internal iliac artery occlusion caused gestational hypertension; however, whether this phenomena occurs in humans is still unknown.</div></div><div><h3>Materials and methods</h3><div>This retrospective cohort study used data from the Birth Certificate Application of Taiwan and linked to the National Health Insurance Research Database and Taiwan Maternal and Child Health Database from 2008 to 2017. Women who underwent internal iliac artery occlusion before pregnant were identified according to diagnosis and procedure codes. The occlusion group included 328 births in 286 women with a history of internal iliac artery occlusion, and the non-occlusion control group included 2,024,882 births in 1,391,288 women.</div></div><div><h3>Results</h3><div>There were no significant differences in gestational hypertension-associated diseases including preeclampsia, eclampsia and HELLP syndrome between the occlusion and non-occlusion groups (4.3 % vs 3.4 %, p = 0.4). The adjusted odds ratios (ORs) of placental previa, placenta accreta spectrum and stillbirth were 1.69 (95 % confidence interval [CI] = 1.12–2.56), 3.99 (95 % CI = 2.52–6.31), 2.57 (95 % CI = 1.13–5.83), respectively, with the non-occlusion group as reference. The adjusted ORs of preterm delivery in the occlusion group were 1.48 (95 % CI = 1.08–2.04) and 2.79 (95 % CI = 1.62–4.82) for a gestational age below 37 weeks and 32 weeks, respectively.</div></div><div><h3>Conclusion</h3><div>Women who underwent internal iliac artery occlusion did not have a higher risk of gestational hypertension and related disease. Their offspring also had similar risks of small for gestational age, poor Apgar score, birth defects and neonatal mortality within 28 days. However, their risks of placental previa, placenta accreta spectrum, stillbirth and preterm delivery were increased.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Pages 303-312"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A digital application increases the accuracy and reduces the time required to determine the stage of endometrial cancer according to the 2023 FIGO staging system","authors":"Nai-Ming Cheng ,&nbsp;Yu-Ting Lin ,&nbsp;Shih-Yao Lin ,&nbsp;Yen-Hou Chang ,&nbsp;Yi-Jen Chen","doi":"10.1016/j.tjog.2024.08.012","DOIUrl":"10.1016/j.tjog.2024.08.012","url":null,"abstract":"<div><h3>Objective</h3><div>The 2023 International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer has significantly increased the complexity of stage determination. We developed a digital application, the Endometrial Cancer Staging (ECAS) application, to assist in determining the endometrial cancer stage. This study aimed to assess whether ECAS can increase the accuracy and reduce the time required for staging endometrial cancer compared to conventional lookup methods.</div></div><div><h3>Materials and methods</h3><div>This self-controlled, paired study was conducted at the Taipei Veterans General Hospital. We designed an evaluation test comprising two parts, each with ten pathology reports. Evaluators with different levels of clinical experience were recruited. They utilized the ECAS application and conventional lookup methods to stage endometrial cancer in different parts of the test. The accuracy and time required for stage determination were collected and analyzed.</div></div><div><h3>Results</h3><div>The ECAS application significantly increased the accuracy (92.1 % vs. 58.1 %, p &lt; 0.001) and reduced the time required (897 s vs. 1152 s, p &lt; 0.001) to determine the stage of endometrial cancer compared to the conventional method. When stratified by specialty, among evaluators without a gynecologic specialty, ECAS showed increased accuracy (90.5 % vs. 52.4 %, p &lt; 0.001) and reduced time (1029 s vs. 1487 s, p &lt; 0.001). For evaluators with a gynecologic specialty, ECAS application increased accuracy (93.3 % vs. 62.6 %, p &lt; 0.001); however, it did not significantly reduce the time required (795 s vs. 890 s, p = 0.098). For complex conditions, ECAS improved the accuracy of stage determination for molecular classification (94.8 % vs. 49.0 %, p &lt; 0.001) and stage IA3 disease (91.7 % vs. 58.3 %, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The ECAS application increased the accuracy and reduced the time required to determine the stage of endometrial cancer according to the 2023 FIGO staging system.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Pages 272-278"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it enough to use cisplatin-paclitaxel-bevacizumab along in the management of stage IVB cervical cancer patients?","authors":"Peng-Hui Wang,&nbsp;Tofan Widya Utami,&nbsp;Tricia Dewi Anggraeni","doi":"10.1016/j.tjog.2024.12.002","DOIUrl":"10.1016/j.tjog.2024.12.002","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Pages 207-209"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal diagnosis of a familial 736-kb Xp22.2p22.13 microduplication encompassing NHS associated with an asymptomatic father carrier and no abnormality in the fetus","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2024.12.018","DOIUrl":"10.1016/j.tjog.2024.12.018","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Pages 379-380"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid prenatal diagnosis of Down syndrome in a fetus with bilateral pleural effusion and hydrops fetalis in the early second trimester by quantitative fluorescent polymerase chain reaction using the DNA extracted from uncultured amniocytes","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2024.12.016","DOIUrl":"10.1016/j.tjog.2024.12.016","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Pages 372-374"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of a heterozygous mutation of MAP3K1 in a 16-year-old girl with primary amenorrhea, sex reversal and 47,XXY gonadal dysgenesis","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2024.12.024","DOIUrl":"10.1016/j.tjog.2024.12.024","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Page 391"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common on “Arteriovenous malformation-related headache and seizures in pregnancy masquerading as eclampsia: A case report”","authors":"Jiaxuan Tan,&nbsp;Hongmei Shen","doi":"10.1016/j.tjog.2024.10.018","DOIUrl":"10.1016/j.tjog.2024.10.018","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Page 394"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosaicism for chromosome aberration with a normal euploid cell line at amniocentesis","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2024.12.026","DOIUrl":"10.1016/j.tjog.2024.12.026","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"64 2","pages":"Page 395"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}