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An identification of human epidermoid growth factor receptor 2 expression in WANG EC-Mol system for endometrial cancer 人表皮样生长因子受体2在子宫内膜癌中表达的研究
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2025.11.002
Peng-Hui Wang
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引用次数: 0
No prominent postnatal decrease of the 47,XXY cell line in a pregnancy with mosaicism for 47,XXY or 47,XXY/46,XY at amniocentesis and a favorable fetal outcome 在羊膜穿刺术中嵌合47,XXY或47,XXY/46,XY的孕妇,出生后47,XXY细胞系没有明显减少,胎儿结局良好
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2025.11.014
Chih-Ping Chen
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引用次数: 0
Hormone receptor, particularly estrogen receptor in WANG EC-Mol system for endometrial cancer 子宫内膜癌中激素受体,尤其是雌激素受体的研究
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2025.11.001
Peng-Hui Wang
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引用次数: 0
Navigating the crossroads: Embracing and regulating large language model in academic writing 跨越十字路口:拥抱与规范学术写作中的大语言模式
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2025.07.030
Himel Mondal
{"title":"Navigating the crossroads: Embracing and regulating large language model in academic writing","authors":"Himel Mondal","doi":"10.1016/j.tjog.2025.07.030","DOIUrl":"10.1016/j.tjog.2025.07.030","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 170-171"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
45,X/47,XXX/46,XX at amniocentesis in a pregnancy associated with a favorable fetal outcome and the karyotype of 45,X/46,XX in the placenta 45,X/47,XXX/46,XX在妊娠羊膜穿刺术中与胎儿结局良好和胎盘中45,X/46,XX的核型相关
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2025.11.015
Chih-Ping Chen
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引用次数: 0
Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 21q11.2-q21.1 in a pregnancy 妊娠期染色体21q11.2-q21.1小多余标记染色体嵌合体的产前诊断和分子细胞遗传学特征
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2025.11.016
Chih-Ping Chen
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引用次数: 0
Prenatal diagnosis of a familial Xp22.12 duplication in a pregnancy with a favorable fetal outcome 产前诊断家族性Xp22.12重复妊娠与有利的胎儿结局
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2025.11.017
Chih-Ping Chen
{"title":"Prenatal diagnosis of a familial Xp22.12 duplication in a pregnancy with a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.017","DOIUrl":"10.1016/j.tjog.2025.11.017","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 161-163"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on “Arteriovenous malformation-related headache and seizures in pregnancy masquerading as eclampsia: A case report” “动静脉畸形所致妊娠期头痛、癫痫伪装为子痫1例”评论
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2024.09.027
Sivalakshmi Ramu, Rinchen Zangmo, Sathiya Seelan
{"title":"Comment on “Arteriovenous malformation-related headache and seizures in pregnancy masquerading as eclampsia: A case report”","authors":"Sivalakshmi Ramu, Rinchen Zangmo, Sathiya Seelan","doi":"10.1016/j.tjog.2024.09.027","DOIUrl":"10.1016/j.tjog.2024.09.027","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Page 167"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral endometrioma of ovary in a 25-year-old woman with unilateral autoamputation and contralateral torsion of ovary: A case report 25岁女性单侧自体截肢伴对侧卵巢扭转双侧卵巢子宫内膜瘤一例报告
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2024.08.019
Chia-Wei Chang

Objective

We report a unique case of bilateral ovarian endometrioma in a young woman with suspected torsion. To the best of our knowledge, no previous cases of unilateral torsion with contralateral autoamputation of an ovarian endometrioma have been reported. This case underscores the importance of laparoscopic management and its potential benefits for preserving fertility.

Case report

A 25-year-old woman with no history of acute abdominal pain was initially diagnosed with bilateral ovarian endometrioma and torsion. During emergent laparoscopic surgery, an autoamputation of the left ovarian endometrioma with reimplantation into the great omentum was discovered incidentally after adhesiolysis. The amputated tumor had blood supply from the left lower quadrant of the great omentum, and concurrent torsion of the right ovarian endometrioma was noted. A cutting notch was identified over the left infundibulopelvic ligament, despite the absence of prior surgical history. This finding supported the diagnosis of autoamputation of the left adnexa due to a previous asymptomatic torsion of the ovarian endometrioma. All masses were removed laparoscopically.

Conclusion

Clinicians should consider spontaneous autoamputation of the adnexa as a potential condition in women presenting with adnexal masses even in the absence of prior abdominal pain. Before undertaking destructive procedures such as adnexectomy or enucleation, a thorough evaluation of the bilateral ovaries should be performed to preserve future fertility.
目的我们报告一个独特的病例双侧卵巢子宫内膜异位瘤的年轻女性怀疑扭转。据我们所知,以前没有单侧扭转伴对侧卵巢子宫内膜异位瘤自体截肢的病例报道。本病例强调了腹腔镜管理的重要性及其对保留生育能力的潜在益处。病例报告一名25岁女性,无急性腹痛史,最初诊断为双侧卵巢子宫内膜异位瘤和扭转。在急诊腹腔镜手术中,偶然发现左侧卵巢子宫内膜异位瘤在粘连松解后自行截肢并重新植入大网膜。切除的肿瘤有大网膜左下腹的血液供应,右卵巢子宫内膜异位瘤同时扭转。尽管没有手术史,但在左侧骨盆底盂韧带处发现了一个切口。这一发现支持了由于先前卵巢子宫内膜异位瘤无症状扭转而导致的左附件自体截肢的诊断。所有肿块均行腹腔镜切除。结论临床医生应考虑自发性自体切除附件,作为一个潜在的条件下,出现附件肿块的妇女,即使以前没有腹痛。在进行诸如附件切除或去核等破坏性手术之前,应对双侧卵巢进行全面评估,以保留未来的生育能力。
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引用次数: 0
Apigenin modulates cell survival pathways and restores olaparib sensitivity in high-grade serous ovarian cancer cells 芹菜素调节细胞存活途径并恢复高级别浆液性卵巢癌细胞对奥拉帕尼的敏感性
IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.tjog.2025.05.020
Jenn-Jhy Tseng , Yeun-Ting Hsieh , Chien-Hsing Lu

Objective

High-grade serous ovarian cancer (HGSOC) presents significant therapeutic challenges, particularly due to acquired resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) such as olaparib. This study examines the potential of apigenin (API), a naturally occurring flavonoid, to modulate survival pathways and restore olaparib sensitivity in HGSOC cell lines.

Materials and methods

Four human HGSOC cell lines (TYK-nu, Kuramochi, CAOV3, and OVCAR3) and their olaparib-resistant derivatives were used. Olaparib resistance was induced by gradually exposing cells to increasing concentrations of olaparib. Cells were treated with API, and cell viability, apoptosis, and cell cycle distribution were assessed using MTT assays and flow cytometry. Western blotting was performed to analyze STAT3 and AKT phosphorylation, apoptotic markers, and cell cycle regulators, while immunofluorescence was used to evaluate STAT3 subcellular localization.

Results

API reduced cell viability in all HGSOC cell lines in a dose-dependent manner, exhibiting differential sensitivity. It induced cell death in TYK-nu and OVCAR3, while causing G2/M phase arrest in Kuramochi and CAOV3. API selectively inhibited pSTAT3 (Y705) and pAKT (S308) without altering total protein levels or STAT3 nuclear localization. Additionally, it downregulated key cell cycle regulators, including p53, p27, p21, and p16 across all lines. Cyclin B1 levels decreased universally, while CDC2 (CDK1) downregulation was specific to Kuramochi and CAOV3, correlating with G2/M arrest. Notably, API restored olaparib sensitivity in resistant Kuramochi and CAOV3 cells by reducing pSTAT3 (Y705) levels, indicating that STAT3 modulation may be a potential mechanism for overcoming resistance.

Conclusion

API suppresses HGSOC progression by inducing apoptosis, arresting the cell cycle, and modulating survival pathways. It also restores olaparib sensitivity in resistant cells, supporting its potential as an adjuvant therapy to enhance olaparib efficacy in combination treatments.
目的:高级别浆液性卵巢癌(HGSOC)呈现出显著的治疗挑战,特别是由于对poly (adp -核糖)聚合酶抑制剂(PARPi)(如奥拉帕尼)的获得性耐药。本研究探讨了芹菜素(API),一种天然存在的类黄酮,在HGSOC细胞系中调节生存途径和恢复奥拉帕尼敏感性的潜力。材料与方法采用4种人HGSOC细胞系(TYK-nu、Kuramochi、CAOV3和OVCAR3)及其抗奥拉帕尼衍生物。奥拉帕尼抗性是通过逐渐将细胞暴露于增加浓度的奥拉帕尼诱导的。用API处理细胞,用MTT法和流式细胞术评估细胞活力、凋亡和细胞周期分布。Western blotting检测STAT3和AKT磷酸化、凋亡标志物和细胞周期调节因子,免疫荧光检测STAT3亚细胞定位。结果api在所有HGSOC细胞系中均以剂量依赖的方式降低细胞活力,表现出不同的敏感性。在TYK-nu和OVCAR3中诱导细胞死亡,在Kuramochi和CAOV3中诱导G2/M期阻滞。API选择性地抑制pSTAT3 (Y705)和pAKT (S308),而不改变总蛋白水平或STAT3核定位。此外,它在所有细胞系中下调关键的细胞周期调节因子,包括p53、p27、p21和p16。Cyclin B1水平普遍下降,而CDC2 (CDK1)下调仅针对Kuramochi和CAOV3,与G2/M阻滞有关。值得注意的是,API通过降低pSTAT3 (Y705)水平恢复了耐药Kuramochi和CAOV3细胞对奥拉帕尼的敏感性,这表明STAT3调节可能是克服耐药的潜在机制。结论api通过诱导细胞凋亡、阻滞细胞周期、调节生存通路等途径抑制HGSOC的进展。它还可以恢复耐药细胞对奥拉帕尼的敏感性,支持其作为辅助治疗的潜力,以提高奥拉帕尼在联合治疗中的疗效。
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引用次数: 0
期刊
Taiwanese Journal of Obstetrics & Gynecology
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