Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.002
Peng-Hui Wang
{"title":"An identification of human epidermoid growth factor receptor 2 expression in WANG EC-Mol system for endometrial cancer","authors":"Peng-Hui Wang","doi":"10.1016/j.tjog.2025.11.002","DOIUrl":"10.1016/j.tjog.2025.11.002","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 10-12"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.014
Chih-Ping Chen
{"title":"No prominent postnatal decrease of the 47,XXY cell line in a pregnancy with mosaicism for 47,XXY or 47,XXY/46,XY at amniocentesis and a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.014","DOIUrl":"10.1016/j.tjog.2025.11.014","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 152-154"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.001
Peng-Hui Wang
{"title":"Hormone receptor, particularly estrogen receptor in WANG EC-Mol system for endometrial cancer","authors":"Peng-Hui Wang","doi":"10.1016/j.tjog.2025.11.001","DOIUrl":"10.1016/j.tjog.2025.11.001","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 7-9"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.07.030
Himel Mondal
{"title":"Navigating the crossroads: Embracing and regulating large language model in academic writing","authors":"Himel Mondal","doi":"10.1016/j.tjog.2025.07.030","DOIUrl":"10.1016/j.tjog.2025.07.030","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 170-171"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.015
Chih-Ping Chen
{"title":"45,X/47,XXX/46,XX at amniocentesis in a pregnancy associated with a favorable fetal outcome and the karyotype of 45,X/46,XX in the placenta","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.015","DOIUrl":"10.1016/j.tjog.2025.11.015","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 155-156"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.016
Chih-Ping Chen
{"title":"Prenatal diagnosis and molecular cytogenetic characterization of mosaicism for a small supernumerary marker chromosome derived from chromosome 21q11.2-q21.1 in a pregnancy","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.016","DOIUrl":"10.1016/j.tjog.2025.11.016","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 157-160"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.11.017
Chih-Ping Chen
{"title":"Prenatal diagnosis of a familial Xp22.12 duplication in a pregnancy with a favorable fetal outcome","authors":"Chih-Ping Chen","doi":"10.1016/j.tjog.2025.11.017","DOIUrl":"10.1016/j.tjog.2025.11.017","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 161-163"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2024.09.027
Sivalakshmi Ramu, Rinchen Zangmo, Sathiya Seelan
{"title":"Comment on “Arteriovenous malformation-related headache and seizures in pregnancy masquerading as eclampsia: A case report”","authors":"Sivalakshmi Ramu, Rinchen Zangmo, Sathiya Seelan","doi":"10.1016/j.tjog.2024.09.027","DOIUrl":"10.1016/j.tjog.2024.09.027","url":null,"abstract":"","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Page 167"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2024.08.019
Chia-Wei Chang
Objective
We report a unique case of bilateral ovarian endometrioma in a young woman with suspected torsion. To the best of our knowledge, no previous cases of unilateral torsion with contralateral autoamputation of an ovarian endometrioma have been reported. This case underscores the importance of laparoscopic management and its potential benefits for preserving fertility.
Case report
A 25-year-old woman with no history of acute abdominal pain was initially diagnosed with bilateral ovarian endometrioma and torsion. During emergent laparoscopic surgery, an autoamputation of the left ovarian endometrioma with reimplantation into the great omentum was discovered incidentally after adhesiolysis. The amputated tumor had blood supply from the left lower quadrant of the great omentum, and concurrent torsion of the right ovarian endometrioma was noted. A cutting notch was identified over the left infundibulopelvic ligament, despite the absence of prior surgical history. This finding supported the diagnosis of autoamputation of the left adnexa due to a previous asymptomatic torsion of the ovarian endometrioma. All masses were removed laparoscopically.
Conclusion
Clinicians should consider spontaneous autoamputation of the adnexa as a potential condition in women presenting with adnexal masses even in the absence of prior abdominal pain. Before undertaking destructive procedures such as adnexectomy or enucleation, a thorough evaluation of the bilateral ovaries should be performed to preserve future fertility.
{"title":"Bilateral endometrioma of ovary in a 25-year-old woman with unilateral autoamputation and contralateral torsion of ovary: A case report","authors":"Chia-Wei Chang","doi":"10.1016/j.tjog.2024.08.019","DOIUrl":"10.1016/j.tjog.2024.08.019","url":null,"abstract":"<div><h3>Objective</h3><div>We report a unique case of bilateral ovarian endometrioma in a young woman with suspected torsion. To the best of our knowledge, no previous cases of unilateral torsion with contralateral autoamputation of an ovarian endometrioma have been reported. This case underscores the importance of laparoscopic management and its potential benefits for preserving fertility.</div></div><div><h3>Case report</h3><div>A 25-year-old woman with no history of acute abdominal pain was initially diagnosed with bilateral ovarian endometrioma and torsion. During emergent laparoscopic surgery, an autoamputation of the left ovarian endometrioma with reimplantation into the great omentum was discovered incidentally after adhesiolysis. The amputated tumor had blood supply from the left lower quadrant of the great omentum, and concurrent torsion of the right ovarian endometrioma was noted. A cutting notch was identified over the left infundibulopelvic ligament, despite the absence of prior surgical history. This finding supported the diagnosis of autoamputation of the left adnexa due to a previous asymptomatic torsion of the ovarian endometrioma. All masses were removed laparoscopically.</div></div><div><h3>Conclusion</h3><div>Clinicians should consider spontaneous autoamputation of the adnexa as a potential condition in women presenting with adnexal masses even in the absence of prior abdominal pain. Before undertaking destructive procedures such as adnexectomy or enucleation, a thorough evaluation of the bilateral ovaries should be performed to preserve future fertility.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 107-109"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.tjog.2025.05.020
Jenn-Jhy Tseng , Yeun-Ting Hsieh , Chien-Hsing Lu
Objective
High-grade serous ovarian cancer (HGSOC) presents significant therapeutic challenges, particularly due to acquired resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) such as olaparib. This study examines the potential of apigenin (API), a naturally occurring flavonoid, to modulate survival pathways and restore olaparib sensitivity in HGSOC cell lines.
Materials and methods
Four human HGSOC cell lines (TYK-nu, Kuramochi, CAOV3, and OVCAR3) and their olaparib-resistant derivatives were used. Olaparib resistance was induced by gradually exposing cells to increasing concentrations of olaparib. Cells were treated with API, and cell viability, apoptosis, and cell cycle distribution were assessed using MTT assays and flow cytometry. Western blotting was performed to analyze STAT3 and AKT phosphorylation, apoptotic markers, and cell cycle regulators, while immunofluorescence was used to evaluate STAT3 subcellular localization.
Results
API reduced cell viability in all HGSOC cell lines in a dose-dependent manner, exhibiting differential sensitivity. It induced cell death in TYK-nu and OVCAR3, while causing G2/M phase arrest in Kuramochi and CAOV3. API selectively inhibited pSTAT3 (Y705) and pAKT (S308) without altering total protein levels or STAT3 nuclear localization. Additionally, it downregulated key cell cycle regulators, including p53, p27, p21, and p16 across all lines. Cyclin B1 levels decreased universally, while CDC2 (CDK1) downregulation was specific to Kuramochi and CAOV3, correlating with G2/M arrest. Notably, API restored olaparib sensitivity in resistant Kuramochi and CAOV3 cells by reducing pSTAT3 (Y705) levels, indicating that STAT3 modulation may be a potential mechanism for overcoming resistance.
Conclusion
API suppresses HGSOC progression by inducing apoptosis, arresting the cell cycle, and modulating survival pathways. It also restores olaparib sensitivity in resistant cells, supporting its potential as an adjuvant therapy to enhance olaparib efficacy in combination treatments.
{"title":"Apigenin modulates cell survival pathways and restores olaparib sensitivity in high-grade serous ovarian cancer cells","authors":"Jenn-Jhy Tseng , Yeun-Ting Hsieh , Chien-Hsing Lu","doi":"10.1016/j.tjog.2025.05.020","DOIUrl":"10.1016/j.tjog.2025.05.020","url":null,"abstract":"<div><h3>Objective</h3><div>High-grade serous ovarian cancer (HGSOC) presents significant therapeutic challenges, particularly due to acquired resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) such as olaparib. This study examines the potential of apigenin (API), a naturally occurring flavonoid, to modulate survival pathways and restore olaparib sensitivity in HGSOC cell lines.</div></div><div><h3>Materials and methods</h3><div>Four human HGSOC cell lines (TYK-nu, Kuramochi, CAOV3, and OVCAR3) and their olaparib-resistant derivatives were used. Olaparib resistance was induced by gradually exposing cells to increasing concentrations of olaparib. Cells were treated with API, and cell viability, apoptosis, and cell cycle distribution were assessed using MTT assays and flow cytometry. Western blotting was performed to analyze STAT3 and AKT phosphorylation, apoptotic markers, and cell cycle regulators, while immunofluorescence was used to evaluate STAT3 subcellular localization.</div></div><div><h3>Results</h3><div>API reduced cell viability in all HGSOC cell lines in a dose-dependent manner, exhibiting differential sensitivity. It induced cell death in TYK-nu and OVCAR3, while causing G2/M phase arrest in Kuramochi and CAOV3. API selectively inhibited pSTAT3 (Y705) and pAKT (S308) without altering total protein levels or STAT3 nuclear localization. Additionally, it downregulated key cell cycle regulators, including p53, p27, p21, and p16 across all lines. Cyclin B1 levels decreased universally, while CDC2 (CDK1) downregulation was specific to Kuramochi and CAOV3, correlating with G2/M arrest. Notably, API restored olaparib sensitivity in resistant Kuramochi and CAOV3 cells by reducing pSTAT3 (Y705) levels, indicating that STAT3 modulation may be a potential mechanism for overcoming resistance.</div></div><div><h3>Conclusion</h3><div>API suppresses HGSOC progression by inducing apoptosis, arresting the cell cycle, and modulating survival pathways. It also restores olaparib sensitivity in resistant cells, supporting its potential as an adjuvant therapy to enhance olaparib efficacy in combination treatments.</div></div>","PeriodicalId":49449,"journal":{"name":"Taiwanese Journal of Obstetrics & Gynecology","volume":"65 1","pages":"Pages 34-43"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}